Give Folic Acid with MTHFR Mutations? Question to Dr Ben – MTHFR.net

Question:  My husband recently started seeing a psych nurse after it was suggested by a family counselor. Our marriage was/is in serious trouble and the counselor thought it might be ADD. The psych nurse says it is MTHFR and that he absolutely cannot have any folic acid. In the very little that I have found on MTHFR, I cannot find anything that says to avoid folic acid. Has my husband completely misunderstood or am I just uneducated?

Answer:
I am happy to see you both working through this together.

Those who have MTHFR genetic mutations have a difficult time ‘being themselves’ due to neurotransmitter imbalance, increased toxicity and fatigue.

Your husband may appear to be present yet he is unable to completely function due to the MTHFR mutation.

It is unwise for me to state if your husband misunderstood or if the psych nurse said something incorrectly.

It is also critical knowing which MTHFR mutation he has.

Those with C677T MTHFR mutations do not process folic acid into methylfolate well.

Those with A1298C MTHFR mutations have issues with biopterin.

What I can say is this:

Supplemental and enriched folic acid foods should be avoided by those afflicted with MTHFR C677T mutations because the MTHFR mutation has partially destroyed the MTHFR enzyme which is required to process folic acid completely.

Natural foods with folate should be consumed by all with MTHFR mutations as food folate helps make other forms of folic acid which are needed for various functions.

Those with C677T MHTFR mutations do not process folic acid into 5-MTHF.

If folic acid does not turn into 5-MTHF, folic acid levels build up. Elevated folic acid has potential to stimulate pre-existing cancer cells.

That said, it is unwise to provide supplemental folic acid to anyone with MTHFR C677T mutations.

However, what one should understand is there is an already methylated, active form of folic acid available. This is L-5-MTHF and is available via supplement form over the counter and is also available by prescription only.

How much 5-MTHF should your husband take?

It is impossible to say without knowing which MTHFR mutations he has and running further lab testing.

Mental disorders are not really a disorder in my book. They are rather dysfunction.

If you are able to identify the underlying cause of the neurological dysfunction, then the ‘mental disorder’ can disappear or be greatly improved.

Knowing that your husband has one or more MTHFR mutations is actually a great first step. MTHFR mutations can be massaged and worked with very effectively – so well in fact that your husband may actually become his actual self.

It would definitely improve his life.

When one has an improved life, their outlook shifts to becoming more positive and flexible.

This may lead to an improved marriage.

In health,

Dr Ben

 

 

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30 Responses to “Give Folic Acid with MTHFR Mutations? Question to Dr Ben – MTHFR.net”

  1. Erika June 26, 2015 at 7:16 pm #

    I have been going through IVF treatments, my new doctor recommended upping my folic acid to 800mg 4times a day. I am so confused. If I am just having trouble digesting it more wouldn’t hurt, right?

  2. Don July 20, 2015 at 8:35 pm #

    I had been taking 3 pills methylfolate 1000mg each morning. Heard half life is 4 hours. Changed to one pill with b12 tab in am, 1 pill with b12 tab pm and 1 pill at bedtime. Surprised to see the difference it made in my mood. Those periods where I just lose touch with myself and snap and scream at the grandkids has disappeared. Is this likely real or placebo effect?

  3. DSA September 10, 2015 at 7:58 pm #

    Hi Dr. Ben – what is your interpretation of the following study? It seem to say that folic acid is still processed even with MTHFR C677T (if I understand it correctly), albeit slower? I am MTHFR C677T and would like to understand it better, in particular if folic acid is simply useless or less effective for me, or harmful and needs to be avoided.

    http://ajcn.nutrition.org/content/93/6/1365.full.pdf+html

  4. Lauriejean November 24, 2015 at 2:46 pm #

    Hi. New to this. Twice breast cancer survivor Now also RA. Have had 4 miscarriages. Sister has the MTRFH , her MS started within weeks of high dose folic acid as she too was miscarriage (3). Within weeks her level was off the chart ( blood). Meaning not able to metabolize. Her tests show from both parents. Under care of a naturalpath. Just want to inform that when adding L-5 form some people have detox like symptoms. Head ache. Spacey… Flu like. Please learn about coffee enemas. This has been vital to dealing with detox symptoms. The how’s and why’s are beyond scoop of this brief note. Please feel free to elaborate Doctor. Thank you for your information!

  5. linda December 29, 2015 at 1:17 am #

    Hello. I recently met with a doctor who tested me for mthfr variations. My result was positive(heterozygous) for mutations of the 677 and 1298. I have been taking 400 mcg of methyl folate along with my multivitamin. I realized my multi contains folic acid. Should I not be consuming any folic acid?

    Thank You,
    Linda D.

    • Dr. Aron January 12, 2016 at 9:19 pm #

      Linda – Yes. You should consider avoiding synthetic folic acid. See:

  6. Judy June 20, 2016 at 11:16 pm #

    Dr. Ben,
    I am very confused. Several years ago, I was diagnosed with heterozygous A1298C. I no longer see that specialist due to distance. I am also positive for chronic Lyme, chronic EBV, fibromyalgia, Hashimoto’s, & HHV6.

    I was told that I needed methyl folate and was sold Pure Encapsulations O.N.E. with L-5-MTHF. I take several other supplements & vitamins including methyl B-12. I am also on Synthroid.

    Do I actually need methy folate? It is so difficult to know if I feel different on the vitamin due to all of my other health issues. The Pure Encapsulations costs approx. $35/month so if it is unnecessary, I hate to be spending the money. If I need it, is there a less expensive product that will meet my needs? Thank you!!

    • Pam September 28, 2016 at 1:55 pm #

      I have Lyme, ebb, biofilm, ect … I did not see a reply to your question? I am new to this sight and have so many questions from my 23-me results. I have sick for over 4 years now
      Any sujestions on how to get help ?

      • Dr Lynch September 28, 2016 at 4:26 pm #

        Hi Pam –

        We all have many questions from 23andMe results. You’re far from alone 🙂 I study it with a team every day.

        I encourage you to run your 23andMe raw data through a reporting tool I developed with my research team.

        It is called StrateGene. You can learn more about StrateGene here.

        Once you get the report, you’ll also be invited to a private Facebook group where you can interact with over 500 StrateGene users (and growing daily).

        The Facebook group has trained health professionals moderating the posts and commenting. You can also read past comments and learn a ton. We have a ton of educational videos as well – free.

        It takes a team and like-minded people to understand our genetic findings.

        StrateGene is that team and I’m honored to be a part of it.

        I look forward to seeing you get the information you need – and the help.

      • Judy September 28, 2016 at 4:41 pm #

        Pam, I received a private message saying Dr. Lynch is no longer answering these posts. Strange, others have replies.

        Anyway, to your question. If you haven’t seen an LLMD, please do. I went undiagnosed for 35+ years on my Lyme. It brought on so many other things. Each person is different but it also has helped to work on building up my immune system. Answers may not show in your genetics as Lyme, EBV, fibromyalgia, etc are not genetic. I do use Triple Magnesium (CVS brand), Jarrows Curcumin 95, and a good probiotic daily. The magnesium helps with my muscle aches & curcumin helps with inflammation. Good luck!!

  7. anne mullins rigdon June 30, 2016 at 5:13 pm #

    Seems dumb that I and others are routinely given a bolus of folic acid with 5flouricil for metastatic colon cancer treatment. The toxicity issues were extreme, foot and hand numbness and intestinal obstruction. Seems like they should test for the gene variant before giving folks the folic acid that probably gave them cancer anyway. Now I am gluten free and alive, against all odds.

  8. Mrs boyd April 19, 2017 at 11:40 am #

    Hello Dr Lynch,
    i have been very unwell for the past 15 yrs, Doctors still dont no whats wrong. with my own research l found l had the MTHFR c677T mutation, but im extremely low in folic acid. im highly sensitive to all foods, medication and chemicals can you please help?
    I have seen one of your doctors here in Victoria Australia , with no help at all..

  9. Alicja A. July 21, 2017 at 12:04 pm #

    Hello,
    I have undergone multiple IVF treatments (5 to be precise, and only one has been successful – resulting in birth of our wonderful son). A total of 8 embryos put in, only 1 of them ‘took’. Next month we are starting another round of IVF – the 6th one, using our LAST frozen embryo.

    Just yesterday I found out was positive(heterozygous) for mutations of 677 and 1298. I have been taking folic acid for about 4 years now. Obviously, in the light of the above revelation, I’m stopping folic acid right away, and bought a folate supplement.

    MY QUESTION IS: in preparation for the next IVF and possible pregnancy, what dosage of folate I should take now?? I have no access to a specialist familiar with MTHFR, and i wouldn’t like to take a dose that’s too high. Could you please respond to my query? It’s very urgent as we’re doing our last frozen embryo transfer in 2 months.
    Thank you.

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