Bedwetting is Normal . . . to a Point
Diapers on newborns must be used because their nervous system is not yet fully developed.
As they progress in age and become little people, their nervous system is moving along nicely.
As children continue to grow and develop, the frequency of bedwetting goes down and eventually stops.
Why do some children continue bedwetting while others stop?
As with many things, there are numerous reasons why a single condition, such as bedwetting, can have multiple contributing causes. As with any condition, working with a health professional is highly recommended.
- Slower central nervous system development
- Food allergies
- Infections (kidney or bladder)
- Excess water consumption prior to bed
- Scared of the dark
- Sympathetic nervous system depleted (stress – frequent eye blinking is a possible sign)
- Medication side effects
- Caffeine (some give this to their kids – and I highly suggest not doing it – and it is also found in many sodas)
Common recommendations by me in the past to help resolve bedwetting are:
- Identify food allergies and remove (gluten and dairy are big)
- No caffeine
- No sodas
- Limit intake of water and fluids prior to bed
- Always have them go pee right before bed
- Use a
blueLOW light night light (doesn’t affect their melatonin levels)
- No iPads or screens before bed or in bed
- Fish oil
Nothing remarkable there really but surprisingly, bedwetting resolves in many children using these techniques.
Bedwetting and New Research
Recently, I read a review from a mother discussing her experience with a multivitamin and bedwetting.
In her review, she linked to a research paper discussing bedwetting and folate/B12 levels.
I am quite thankful for her providing this link as I did not think about B12/folate and bedwetting.
Yet I should have.
First of all, thank you ‘happymom’ for providing this research link!
Secondly, I should have made the connection between bedwetting and B12/folate.
I already gave you a big hint above – and I already knew the answer – just from a limited perspective.
What was the hint?
Bedwetting occurs in those with delayed central nervous system development
All the reasons above about bedwetting are focused on WHAT contributes to bedwetting.
They do not delve into WHY some children continue to suffer from bedwetting (and parents as well).
Before we get into WHY, let’s discuss what some researchers found.
The title of the 2012 paper identified by ‘happymom’ is called:
Decreased Vitamin B12 Levels in Children with Nocturnal Enuresis
(BTW – nocturnal enuresis is doctor-speak for bedwetting.)
It was a fairly small study (n = 61) yet areas did reach statistical significance.
The B12 levels were lower in the bedwetting group compared to the control group. This variable reached statistical significance (p = 0.003)
The mean folate levels were also lower in the bedwetting group compared to the control group. This variable did reach statistical significance (p = 0.025).
Low folate was also seen in two of the children in the bedwetting group compared to none in the control group; however, this did not reach statistical significance. If the study was larger, perhaps it would have reached significance.
Another study, a more current one (2015), looked at the relation between B12, folate and iron in children aged 6 to 12 with nocturnal enuresis.
They found similar results as the 2012 study:
- low mean B12 in the bedwetting group compared to control
- low mean folate in the bedwetting group compared to control
However, their study found that the low mean folate reached statistical significance but not the low mean B12.
This study was even smaller than the 2012 study so this makes it more difficult to reach statistical significance.
More studies are needed here – and I’d like them to evaluate a few genetic polymorphisms like MTHFR, PEMT, DAO, TCN2, COMT, FUT2 and some others.
In summary, both papers identified lower B12 and lower folate in children who are bedwetting compared to those who are not.
The question is: What do these results mean?
What two nutrients are critical for central nervous system development?
What two nutrients are critical for methylation?
What two nutrients were low in children with bedwetting?
How did I miss this?
Let’s put it together:
A + B = C
A known cause of bedwetting is slower development of the central nervous system + low b12 and low folate contribute to a slowed central nervous system = increased susceptibility to nocturnal enuresis (ie. bedwetting).
If one has low folate and low B12, then their methylation system is going to be less functional.
As their methylation is not up to speed, then the development of the CNS is hindered.
As the CNS development is hindered, so is the nervous system of the bladder which leads to nocturnal enuresis.
Restoring nutrients for CNS development is critical to reducing bedwetting.
We can add these to parental patient history in order to evaluate potential B12/folate deficiencies:
- “As a child, did you experience difficulties with bedwetting? If yes, what age did you stop?”
- “How old is your child?”
- “Does your child wet the bed at night fairly consistently?”
There is family history in bedwetting. Since there is family history, it leads me to believe that there is some genetic component to it, yes?
Let’s summarize the growth of a child and their demand on methylation:
The younger the child, the more development they are experiencing. The more development they are experiencing, the more methylation they are utilizing. The more methylation they are utilizing, the more nutrients they require to support methylation.
If the child’s methylation is not supported with nutrients, then bedwetting may show up.
Nutrients which support methylation are:
- Folate (as methylfolate)
- B12 (as methylcobalamin)
- B2 (supports MTHFR enzyme)
- Choline (from protein – esp eggs and shrimp)
- Glycine (from protein)
- Methionine (from protein)
Resources to identify foods which provide these nutrients:
Increased risks for methylation dysfunction in children:
- Medications (antacids given to infants often…)
- Limited protein intake (they need around 0.8 grams of protein per 2.2 lbs of body weight)
- Limited vegetable consumption (provide folate and fiber)
- Limited red meat intake (provides B12)
- Limited healthy carbohydrate consumption (grains provide B2 and B6)
- High refined carbohydrate consumption (low protein and fat intake)
- Stress (uses up methylation nutrients faster)
- Genetic polymorphisms (MTHFR, CBS, MTHFD1, DAO, COMT, MAO, MTRR, DHFR, and others)
Lab Tests to consider:
- CBC with chem panel
- serum folate (can show ‘high’ yet be ‘low’ functionally)
- serum ferritin
- serum cobalamin (can show ‘high’ yet be ‘low’ functionally)
- urinary organic acids
- plasma amino acids
- urinary methylmalonic acid
- whole blood histamine (maybe)
- CDSA (if having digestive complaints)
- genetic testing (possibly – only when ready mentally and having a doctor who understands how to interpret)
- others which your doctor feels appropriate
Supplementation to consider supporting bedwetting:
(NOTE: This is not a list stating to take all – they are options to consider with your health professional)
- Kid’s Optimal Multivitamin Capsules or Optimal Multivitamin Chewable or Optimal Multivitamin Powder: provides B12 as methylcobalamin and adenosylcobalamin, provides folate as methylfolate in all multivitamins and some multivitamins also have folate in combination – methylfolate and folinic acid (supports DNA base production).
- Optimal PC: provides phosphatidylcholine – which requires over 70% of the bodies methylation to produce. Supporting the body with phosphatidylcholine may reduce the burden on methylation. This is not known – only theory. Comes in liquid (thick like molasses) and gelatin capsules which are quite large and hard for kids to swallow.
- Optimal Creatine: along with phosphatidylcholine, creatine is a major consumer of methyl donors. Supplementing with creatine may reduce the burden on methylation. This is not known – only theory. Side note: creatine is commonly low in child with speech delays – due to a GAMT polymorphism or methylation dysfunction or both.
- Optimal Liposomal B12 with L-5-MTHF: an easy-to-administer liquid of B12 as methylcobalamin (and folate as methylfolate (just a touch per serving (only 100 mcg per dropperful).
- Active B12 with L-5-MTHF Lozenge: is a lozenge of B12 as methylcobalamin, adenosylcobalamin and also folate as methylfolate. This can be broken apart into smaller pieces. Dose depends on what your doctor recommends. Starting low and working up is recommended. If taking a multivitamin, this may not be needed. If taking the liposomal B12, this is likely not needed. Again, talk with your doctor.
- Active B12 Lozenge: provides 5,000 mcg of methylcobalamin and adenosylcobalamin in a lozenge. No folate. Lozenge may be broken into smaller pieces. Again, talk with your doctor about dose.
- Optimal Adrenal: provides herbs and some nutrients to help reduce stress response. If a child has frequent eye blinking or noticeably stressed out, Optimal Adrenal may prove useful (along with removing stressors).
Success in resolving your child’s bedwetting?!
Please share your story below. How did you resolve it?
Still struggling with resolving your child’s bedwetting?
Share your story below and also please follow up and let us know how these recommendations have helped!
I look forward to reading them!
PS – Bedwetting also occurs in adults. There are some additional reasons why adults suffer from bedwetting – but considering the above reasons may be a good place to start.
This pediatric clinic has a fantastic article on bedwetting. I do not agree with the use of medications, however. Not in this instance.
If you are looking for a health professional to help you and are struggling, then I recommend looking here – at Seeking Health Educational Institute. These health professionals have been to my conferences or taken the online training programs.
For health professionals:
I also have extensive online conference recordings available here – and some offer CE credits as well. If you’re just starting out, I highly recommend this 90 minute conference recording entitled, Practical Clinical Applications of Methylation and Epigenetics.