Conversation Between Two Doctors on MTHFR

Comment from a colleague of mine from a forum:

Hello Ben,

We cannot go overboard about MTHFR gene mutations. It’s just one of many gene mutations possible in the body and comes in mild, moderate and severe presentations. The physiologic problem with MTHFR mutations is lack of methylation and elevating homocysteine is the key point of all that occurring. If the person has a heterozygous gene mutation and without treatment their homocysteine is 7, I’m sorry, but that gene mutation is mild and the body is working fine with it. There is no need to panic the patient and elevate their gene mutation to some nasty alien about to burst out of their chest. It’s under control–look for Obstacles to Cure elsewhere. Even with a homozygous C677 and homocysteine of 21 untreated, if they take folic acid/MTHF and get their homocysteine down to 7, again, the damage is under control and the body is methylating and working fine. The mutation is dealt with successfully and again, no need to do a gloom and doom thing with the patient; just keep them on their supplementation for life. It’s like having hypothyroidism--yeah, not good if left untreated for years, but if the patient is on thyroid medicine and doing great and their TSH/FT3/FT4 are normal, then move on. Don’t keep telling them their thyroid is a problem; it’s not anymore if they take their meds.

The problem is we have many patients with gene mutations and elevated homocysteine levels who are undiagnosed, like I was, and walking around for many years with potentially damage occurring to their bodies. Indeed that damage has many studies showing it can affect nearly every part of the body and many biological systems, since methylation is so vital a component of our physiology. So, we just need to catch patients with elevated homocysteine and treat it successfully; then they should do fine.

I am not about doom and gloom.

On the contrary.

It is a passion of mine to educate and inform – and empower.

I feel strongly that those who have recurring miscarriages – with heterozygous MTHFR and ‘normal homocyteine’ are being ignored – and there are a LOT of women out there like this.

Yes – there may be other reasons for the miscarriage – many other reasons. But when a woman tells me she has been tested for everything under the sun for things and only thing positive is a heterozygous MTHFR, I listen. When another woman says the same thing, my ears are doubly interested. When yet another one says the same story – I really start thinking that something is being missed.

My theory is a simple one.

Here is my theory in a nutshell


Those woman with heterozygous MTHFR and miscarrying may have a partner who is passing on another MTHFR mutation.

I am empowering people with MTHFR and helping them get better – I am not instilling fear.

Here is one statement I received yesterday:
“For over a month I have been following the regimen of supplements that Dr. Ben recommended in his consult for me for my MTHFR mutations, and the severe depression that resulted from them. I am happy to say that I feel so much better, I am going OFF of disability and going back to work. I am off my SSNRIs and my anxiety has reduced considerably. I feel “normal” again and I am starting to enjoy life. I am grateful to Dr. Ben for giving me my quality of life back!”

“Dr. Ben helped me improve my health by giving me insight on the MTHFR gene mutation that I have. My health has improved tremendously . My hair is no longer falling out of my head. I am more energetic than I have felt in years. It is about time that we have more professionals step up to the plate and acknowledge that MTHFR deficiency is serious and can kill if not treated. I learned many positive things from Dr. Ben to improve my quality of life.”

All I ask is that we have an open mind beyond what the research is showing.

Research is not always right and with MTHFR – it is sparse.

Research is needed more in this area.

Dr Ben

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8 Responses to “Conversation Between Two Doctors on MTHFR”

  1. Ben Potter May 1, 2014 at 2:59 pm #

    I was diagnosed with mthfr 3 years ago my homocysteine level was 47 after a year and a half of therapy my levels only went down to 39 I’ve had multiple P.E. And DVT. I decide to take matters into my own hands because my doctor wasn’t sure what to do my levels weren’t going down any further. Now for the interesting part, I was 35 at the time of diagnosis and I had spent the better part of my life in the gym off and on, also training to fight since I was 12 years old when my body would allow, so I was curious as to how I wasn’t dead from a clot from all the years of fighting. So I went back and looked at the supplements I was taking and decided that if I wasn’t clotting while I was training something must’ve been helping me so I started taking one product called Nano Vapor and within 6 months I lowered my homocysteine level to under 11, I now longer have energy issues and I’ve lost 60 pounds. I guess I should clarify the weight loss , I had weight problems off and on no matter what I did once I got my homocysteine level down I have no weight issues , I still have headaches daily plus my left calf is twice the size as my right and hurts all the time from the DVT damage but I feel great . My concerns are how safe is nano vapor for me because my doctors aren’t sure or should I just be happy that I’ve got some of my life back

    • c February 18, 2016 at 3:04 am #

      What type of “Therapy”? Were you taking betain and b12 as well as l methylfolate?

    • Suebee April 22, 2016 at 4:00 pm #

      I am compound heterozygous Mthfr and have elevated homocysteine. I am wondering how are your levels since your last post. I have not started treatment yet due to GI issues. Did you have any problems with methylation. New to all this. I stay weak and nauseated. I feel like no one understands these issues related to this mutation. Would appreciate any feed back.

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