Dr. Lynch talks MTHFR, Methylation, and Folic Acid

Depression, anxiety, insomnia, recurrent miscarriages, blood clots, cardiovascular issues – just some of the symptoms of MTHFR. Dr. Poppy Daniels, an obstetrician/gynecologist,  interviews Dr. Lynch on the direct and indirect effects of MTHFR, the process of methylation, and why folic acid does not constitute methylfolate.

With approximately 1 in 2 people having a MTHFR SNP, it’s a significant problem, one that is often under-diagnosed or misdiagnosed. But before you run out and get tested, listen to Dr. Lynch’s recommendations for lab tests and an accurate diagnosis.


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9 Responses to “Dr. Lynch talks MTHFR, Methylation, and Folic Acid”

  1. Lisa Dennys September 10, 2014 at 1:43 am #

    Thanks to Dr. Ben & Dr. Poppy for continuing to raise awareness about MTHFR. Dr. Ben, I always learn so much from your interviews & presentations . It helps me to continue in my own advocacy in my MTHFR treatment & is much appreciated!

  2. Lisa Dennys September 11, 2014 at 1:51 am #

    Thanks so much for your ongoing valuable information such as this online, Dr. Ben.It helps me have hope and accurate, concrete facts when advocating for myself in the health care system trying to sort out my MTHFR issues.

  3. Rick Fleming September 11, 2014 at 6:22 pm #

    What dose do you recommend for methylated B12?

  4. Brenda July 29, 2015 at 8:27 am #

    Dr Ben,

    Gosh, I’m very confused and really need your input.

    Two years ago while pregnant my perinatologist put my on fabb tablet as I was diagnosed homozygous 677 double mutation. She also said this is something that I will probably end up taking for the rest of my life. It is my understanding that this is prescribed folic acid and precisely what I shouldn’t be taking as my body has the inability to break it down ?? Right??
    What I should be taking is methylfolate? I just can’t help but wonder if this is actually been harming my body? Here’s the interesting part, I am also being prescribed Omeprazole of which I’ve been taking for 6+ years. Again, as I struggle to better understand my diagnosis I am under the impression that I should not be taking any sort of inhibitor or acid reductase ?

    I am 47 and had my son at almost 45. He is my third child and appears to be a healthy strong toddler. My two older children are also healthy. When I was 19 years old I had a stroke which at the time was contributed to both control pills. It wasn’t until I was pregnant two years ago that I was actually diagnosed with mthrf. This answers so many questions to things that have never made any sense to me my whole life. Things like why I’ve always been such a tired person, my stroke, depression issues and why medications do not work for me etc.

    Should I stop taking the fabb tab immediately and begin methylfolate? I am so frustrated because my doctor obviously doesn’t understand the MTHFR diagnosis and how to treat me. I need help as I have every reason and need to be healthy for my children especially with a little 2 year old guy.

    What is the importance of having my children checked? Lastly Dr Ben, again this is my understanding and please correct me if I’m wrong but people with my diagnosis usually have a hard time conceiving and suffer multiple miscarriages however I have always been the opposite very fertile. Could this gene mutation have been passed down to my oldest daughter as she struggled with fertility and when she finally did become pregnant she miscarried at 3 months. I have a lot of guilt over this because I wonder if this could have been prevented had she been tested and treated accordingly. She passed away last year at 21 from a heroin overdose and I believe it was because she suffered from depression around her losing the baby. This is a lot for me to take on. I’m not sure if your answer is going to give me some relief or perhaps just confirm my fear but I really need to know. At the time I didn’t even understand my own diagnosis and the enormous/devastating effects it has on the body if not acknowledged and treated. HELP -HELP -HELP PLEASE HELP ME.



    Brenda Wandling

    • Dr. Aron August 6, 2015 at 7:17 pm #

      Hello Brenda – I’m so sorry to hear about your daughter. This is a lot to take on for you I’m sure. Step 1 is to start looking for a doctor who has training in this area. You can start looking here: Physician Directory. The FaBB tablet contains folic acid (synthetic form of folate), which is not easily converted to the methylfolate, the form your body needs and uses best. Also, being on Omeprazole for 6+ years is just way too long. Long term use can result in malabsorption of important nutrients…B12, calcium, magnesium, probiotics, iron, and zinc. A good doctor will help you get to the bottom of this. Since you have an MTHFR polymorphism and if your children are experiencing health issues, it would be helpful information to know their MTHFR status.

      Here are articles to read next:
      Dr. Ben’s General Starting Protocol
      Preventing methylfolate side effects
      Prenatal Supplementation

      I hope this gives you some next steps to get you moving in the right direction. Please keep us updated! Wishing you all the best.

  5. Lori January 24, 2016 at 5:11 am #

    Hello Dr. Ben, this is the first time I have taken a step towards my histamine intolerance issues. I definitely have folic acid problems. Currently I am taking Folate (as Quatrefolic 6S-5-Methyltetrahydrofolic acid, glucosamine salt). And my body HATES it!! I am no longer taking it, and feel really good, without it. I am really struggling with ezema issues on my face and back, and I itch (sometimes). I am trying to cut way back on animal protein, and take quercetin/vitc to help with histamine. I also find it hard to get a good nights rest. I don’t know how I got in this situation in the first place. I also, cannot find the correct probiotic. This is an ugly vicious cycle. I have taken DAOSIN, diamine oxidase, supplement on occasion. Should I see my Dr. about testing? I don’t even know what I’m talking about, (testing). I have 2 daughters and I for sure do not want them to suffer like I am now. FYI- taking Spirulina makes me feel better. ??? Is this a mast cell stabilizer? Personally, taking supplements and the such is good, but I need to get to the ROOT of this problem.Can you please help me? I would appreciate it. Thank you. Lori

  6. Linda Harding January 12, 2017 at 2:24 pm #

    J Am Coll Nutr. 2016 Aug;35(6):514-520. Epub 2016 Mar 2.
    Supplementation with Watermelon Extract Reduces Total Cholesterol and LDL Cholesterol in Adults with Dyslipidemia under the Influence of the MTHFR C677T Polymorphism.
    Massa NM1,2, Silva AS3,2, de Oliveira CV1,2, Costa MJ1,2, Persuhn DC4,2, Barbosa CV1,2, Gonçalves MD1,2.
    BOTTOM LINE new reseach shows watermelon helps correct cholesterol levels . . . .
    Dyslipidemia and genetic polymorphisms are associated with increased risk for developing cardiovascular diseases, and watermelon appears to have the potential to improve hyperlipidemia due to the presence of nutrients such as arginine and citrulline.
    To test the hypolipidemic effect of watermelon extract (Citrullus lanatus) and the influence of the methylenetetrahydrofolate reductase genotype (MTHFR C677T) on supplementation response.


  1. The 5-Second Newborn Check All Parents Should Do: A Follow-Up | The Paleo Hygienist - September 25, 2014

    […] information on the MTHFR gene mutation, methylation and his supplementation recommendations here.  I will note that if you listen to the interview, Dr. Lynch seems to have the common […]

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