Endometriosis is a female health disorder that is a chronic, estrogen-dependent inflammatory disease characterized by growth of endometrial tissue outside the uterine cavity.
First question you should be asking yourself is: Why would endometrial tissue grow in other areas of the body??
Before the connection is shared between MTHFR and endometriosis, one must understand what is a disease.
We typically think of disease being caused by infection.
Let’s define disease:
- Disease = a pathological condition of a part, organ, or system of an organism resulting from various causes, such as infection, genetic defect, or environmental stress, and characterized by an identifiable group of signs or symptoms.
If endometriosis is not caused by infection, then it must be caused by either genetic defects and/or environmental stressors.
Endometriosis is caused by both genetic defects and environmental exposures.
Endometriosis and Environmental Stressors
What in the environment would cause uterine cells to grow in other parts of the body?
In one word, that can be answered.
Xeno means, “indicating something foreign, strange or different.” 
Estrogen means, “a generic term for estrus-producing compounds; the naturally occurring female sex hormones include estradiol, estrone and estriol.
A xenoestrogen is a foreign substance that stimulates the production of estrogens.
Xenoestrogens In the Environment:
- Bisphenol A (BPA)
- Polychlorinated biphenyl (PCB)
- some Pesticides
- some Herbicides
- Polyvinyl chloride (PVC)
Endometriosis and the Genetic Defect Connection
In order to process xenoestrogens, one must have functional detoxification pathways.
There are countless genes whose function is to detoxify substances and eliminate them from the body. A few of these genes are known as MTHFR, COMT, SOD1, SOD2, GSTM1 and various CYT.
If these genes are mutated or deleted, then the elimination of xenoestrogens is limited at best.
The MTHFR gene mutation, especially the C677T form, may cause a deficiency in the production of the body’s largest single carbon donor, SAMe. SAMe is extremely important in detoxification .
MTHFR C677T individuals are limited in their ability to produce glutathione, which is a significant contributor to detoxification.
The ability to eliminate xenoestrogens is compromised when one is deficient in SAMe and glutathione due to a MTHFR C677T defect.
Endometriosis may then become an issue.
Solutions to Prevent and Eliminate Endometriosis:
- Avoid xenoestrogens
- Eat organic, whole food
- Limit exposure to artificial chemicals and utilize green-friendly products as often as possible
- Sweat often using sauna, exercise, yoga, epsom salt baths
- Support liver detoxification pathways
- Supplement with glutathione or take the precursors of glutathione – or both
- Test for the MTHFR defect
- Support the C677T MTHFR defect with the right lifestyle, diet and supplements
- Balance methylation
- Identify potential genetic defects which compromise detoxification