Folate and Methylation Deficiencies: Webinar Recordings

On July 10th, Mike Mutzel of Xymogen hosted me for an informative webinar on folate and methylation deficiencies.

Please watch and share with others.



Since there was no time for Q and A in the first webinar, I have done another webinar (recording below) dedicated simply to answering your questions:


Questions? Comments? Do post below.

Need more information? Want to really focus on methylation deficiencies and nutrigenomics?

There are still seats available for the Two Day Seminar for 15 CEU’s at Bastyr University 

Nutritional Support for Folate Methylation Deficiencies may be found at

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10 Responses to “Folate and Methylation Deficiencies: Webinar Recordings”

  1. melvin July 12, 2013 at 11:56 pm # Reply

    Great webinar…won’t be able to make it to the 2 day seminar. You said in another post that it will now be recorded, that’s great news. Please inform us how we can purchase a copy of the seminar as soon as possible.

    Thanks for all you do

  2. Hans July 13, 2013 at 1:22 am # Reply

    Do you have some more statistics for how many percent of the population is affected by other SNPs such as CBS, SOD, NOS etc?

  3. Jackie July 13, 2013 at 1:33 am # Reply

    Hi –

    Thank you very much for presenting the Webinar this week on the Methylation cycle. It was very enlightening, and I learned a lot – including now why I cannot tolerate green tea, of all things! It now makes sense as to why I was in pain and chronically insomniac after having a cup of green tea, so I will not try to have that anymore. But anyway, I am looking forward to learning more during the Q&A coming up next week, and really appreciate all of the research and efforts you are making to help unravel this difficult health problem, in trying to help people who suffer with these mutations.

  4. Diana Killen July 15, 2013 at 2:13 am # Reply

    Great webinar thank you! Re B12 and folate both supporting Phase 1 liver detox: for people with a fast stage 1 will this speed it up, slow it down, or do they act as adaptagens?

    Would like to know more about dealing with CBS mutations if client is not obviously sulphur intolerant, but has sulphur and glutathione depletion due to heavy mercury (amalgam) load.

  5. Deborah Sie, NMD July 15, 2013 at 12:27 pm # Reply

    I have a few questions for next weeks webinar:
    1) Do you find the low sulfur diet important in CBS mutations? Do you notice a difference right away? Do you put people on low sulfur or low thiol diets?
    2) Have you seen OCD gradually improve with the supplementation of 5MTHF? Do you see a pattern of this in people with methylation SNPs?
    3) Are there any studies or theories about reversing infertility with supplementation of 5 MTHF or do homozygous individuals remain infertile?
    Thanks for helping us all in understanding this critical health anomoly.
    Deborah Sie, NMD

  6. Janis Bell July 22, 2013 at 5:42 pm # Reply

    Is there a way you can post a downloadable audio only file? Some of us are in rural areas and depend solely on wifi. We cannot watch videos or movies. I would really like to get this as a wav file or as a podcast.
    Janis Bell NMD

  7. Michael July 25, 2013 at 9:16 pm # Reply

    Hi, I’m listening to your webinar…I’ve had serious anxiety/panic that came out of nowhere, which led to adrenaline rushes, then severe insomnia. Then, after trying SSRI’s which made me much worse, my emotions were wiped and became depressed. I was tested for the two common MTHF gene issue, and they came back normal. I’ve been on a amino acid protocol containing, 5-htp (seems to over stimulate me, and I also feel that I have enough Serotonin), mucuna (l-dopa), tyrosine, Choline, Pantothine, MSM (cystein seemed to make my stomach feel funny), and SAM-e. I do take methlyb12 and 5-MTHF (folate). Now, here are some findings from a Genova NutraEval test. It showed that I have a HIGH need for B12. But….I had some mag/b shots done a year ago or so, which eventually made me feel worse. Anyway, I know have a HIGH amount of B12 in my blood, it’s not being used up…It’s been that way for over a year now. The test also shows I had a high need for glutathione… Why isn’t my B12 being methylated used up? I don’t have the MTHF common mutated genes, but I hear that those who are under methlyated/high histamine, then Folate can be bad? I also had blood work that shows I have high/normal histamine, and high/normal homocystein. The amino acid mix helped to a point, but I continue to feel depressed, no energy, can’t sleep properly, etc… A couple of other notes, my testosterone is lower than it should be, but still in normal range (300’s). And my estrogen is elevated…not sure if this has anything to do with methylation. Anyway, I think due to all the anxiety and depression and insomnia for the past 2 years, my adrenals are a bit fatigued. Anyway, with all this info, can you take a guess at which area of methylation I might be stuck in and what nutrients might help? I’ve already spent literally 20k plus on tests, doctors, meds and supplements. I went bankrupt and lost my home due to this illness that no doctor has been able to help me with…And I still feel awful. On occasion I do get some relief, and I will feel almost normal then moments or hours later I feel awful again. Some times after eating a meal, no matter if it’s a organic salad and chicken or something not has healthy. I stay away from gluten, dairy and eggs. I some times feel a perk, mood lift after drinking my amino acid mix, but it’s short lived. Some times I feel over stimulated by it. I think lowering/dropping the 5-htp and lowering the amount of tyrosine helped with some of the over stimulation feelings I was having.. Not sure if dropping the SAM-e helped. I wanted to add DMG and Methionine to make SAM-e as it was cheaper and doesn’t have all the fillers that SAM-e pills have…Not sure if this is a good idea or not. I seemed to feel a little better, but then having strange episodes of feeling intense anxiety and thoughts of how ill I felt a year ago like PSTD or something. Not sure what is up. I just want to feel better. I’m at a point where I’m open to any suggestion. SSRI’s are out of the question. Thought about trying St. John’s Wort. My thyroid tests okay all the time. (I do have small cysts on my thyroid and a nodule on my left adrenal gland but the Endo said it’s fine, and no tests pointed to any issues) I did show having elevated calcium a couple of times. Not sure if that is parathyroid issue or not having enough magnesium? Also, magnesium some times over stimulated me. A year ago or so, magnesium for a short time calmed me, but never had the effect since. Sorry, a little long but hopefully enough insight to come up with some suggestions? Blessings…….

  8. Lynn September 19, 2013 at 5:24 pm # Reply

    I started taking samE about 3 weeks ago for presumed methylation issues. F.

  9. Lynn September 19, 2013 at 5:36 pm # Reply

    I started taking samE for presumed methylation issues about 3 weeks ago because a friend of mine reads your stuff and suggested it. FOR THE FIRST TIME IN MY LIFE, AND FROM THE VERY NEXT MORNING, i woke up NOT FEELING LIKE I HAD JUST AWAKENED FROM ANESTHESIA. i just thought everyone woke up in a severe haze like that every day. Now i wake up and my brain actually works!. I had been so sick…cancer and severe immune deficiencies my whole life but worse after cancer and making me bedridden for months after my cancer treatments. I had done other things that have helped me get better thru nutritional support and supplements but this samE has been miraculous for me. I will have to get the testing so my treatment can be pinpointed but I am so thankful.


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