23andMe results – My Story of Depression and Recovery

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    Throughout life I have always wondered what was wrong with me. I never did fit in with any crowd as I was socially awkward. I grew up not having very many friends. I was always a loner, I have been called everything from “weird” to “lazy” to “useless”. It didn’t help that I have emotionally abusive Asian parents, and a mother with narcissistic personality disorder. Because of this I had very low self esteem and sensitive to criticism. No matter how hard I try, I was never good enough for my parents (or anyone else for that matter). We are currently not on speaking terms.

    For as long as I can remember, since I was a child I was always skinny with ADHD, Anxiety, Depression, and Asperger’s symptoms. I thought it was just bad genes and there was nothing I can do about it. I would eat very slow, fall asleep on the chair next to me during dinner. I have always avoided hard to digest foods (any meat that isn’t soft or doesn’t have fat) and preferred to eat soft foods like noodles, soup.

    Fast forward to high school I started noticing I felt too lazy to walk between classes. I would stay up late to do homework as I could only focus and get assignments done starting 11pm-2am. Later I learned the word procrastination and boy did I procrastinate a lot.

    During university I had much of the same problems, only the chronic fatigue started settling in. I could not figure out why all the other students can walk so far without getting tired. I thought it was because I just wasn’t used to exercising. Through a lot of hard work I was finally able to graduate (took me 6 years to graduate from a 3 year program), but not before I was exposed to mold and pesticide in an old house I lived in during my time in university. I then had a recurring nightmare for a while after that and the dream was about needing one more course to graduate.

    While I was in university, I slipped and fell on ice one day while catching the bus. My butt hurt but I didn’t go to hospital thinking I would be ok. I couldn’t be more wrong as I realized it likely contributed to my back injury at my first job after graduation. After losing my first real job, I was very stressed and that was when I was diagnosed with Fibromyalgia. The doctor prescribed me Paxil which gave me major acid reflux, after which I became very depressed over the next 5 years. During this time I barely left my home, was very lonely but did not want to talk to anyone, spent all my time in front of the computer on eBay, etc.

    Later on in 2009, I randomly applied to a local job and was happy to be starting a new job. Once again, I was so anxious that I could not sleep the day before the first day of work. I did well enough but about a year later my arms were slowly hurting badly, I knew I wouldn’t last much longer but I kept going until they got so bad it was like burning pain as if they were on fire! Eventually I lost that job again due to repetitive strain injury/fibromyalgia.

    This time since I was on workplace disability, I was eventually referred to a local doctor, a pain specialist who has helped many people with fibromyalgia. It was then that I started having a different outlook on things. I learned that in order to recover, we need to find the cause of the illness. Treat the cause, not the symptoms. There was an underlying issue causing my fibromyalgia. I just had to find out what that was.

    My symptoms are many. I am now 36 years old (female) and have been diagnosed with the following :

    – Fibromyalgia
    – ADHD
    – Asperger’s Syndrome with Learning Disability
    – Bipolar Disorder
    – insomnia (difficultly falling asleep, night time awakenings, messed up circadian rhythm, non-refreshing sleep, sleep paralysis)
    – mercury & pesticide poisoning
    – back pain
    – bilateral sacroiliac joint problems
    – TMJ/temporomandibular joint pain syndrome
    – overactive bladder
    – depression, mood issues, irritability, anxiety, nervousness, shyness
    – inability to concentrate, short term memory loss, auditory processing problem
    – chronic fatigue syndrome, muscle weakness, muscle atrophy, heavy legs
    – repetitive strain injuries, loss of balance
    – Gastrointestinal and digestive issues/acid reflux/GERD
    – dry eyes and constant dry mouth, tonsil stones, dehydrated despite adequate fluid intake
    – IBS/irritable bowel syndrome, frequent urination, bladder prolapse
    – electromagnetic hypersensitivity
    – sensitive hearing/taste/smell, hearing high pitch sounds
    – chronic androgen insufficiency, osteopenia, proteinura/protein in the urine
    – food allergies, skin rashes, frequent headaches
    – repeated infections (viral/fungal/bacterial/candida)
    – hypothyroidism, cold hands and feet/extremities
    – loss of libido, slow healing, sleep apnea
    – heart palpitations, trouble breathing
    – poor driving/sense of direction
    – crawling sensations especially during parasite detox, brain fog, procrastination

    I have been doing a lot of detox lately and it certainly helped my symptoms. My brain fog, fatigue, sleep, mood, anxiety, procrastination, mental clarity, expressing thoughts, parasite symptoms, have all improved. The fibromyalgia and focus/concentration issue has never improved however.

    Unfortunately due to methylation problems I am always stuck and can’t go further. I then realized I may have a MTHFR gene defect which would mean I need to take care of my methylation pathways first before doing any further detox. I found that every detox, other than gut cleanse products, makes me more bloated. Thanks to a doctor in Vietnam, I have done parasite cleanse with lots of drugs (Triclabendazole, Ivermectin, Praziquantel), heavy metal/mercury detox, mold detox, etc. He told me I most likely have Lyme Disease.

    Lately I am very bloated. Can’t even eat anything without having yeast symptoms flare up. I had gluten-free cereal this morning and right afterwards had a crash (feeling very tired, poor circulation, depressed).

    I look very skinny, with a belly sticking out as if I was 5 months pregnant. I think I look similar to those poor children in Africa.

    Hopefully someone can help interpret my 23andMe results? I ran it through Livewello also. What supplements should I be taking and what dosage? Any MTHFR specialized doctors in Toronto, Canada?

    During my 2009 job, I became friends with a coworker and it was through her that I met my boyfriend. He is now 25 years old and although he is physically healthy and fit, mentally he wasn’t.

    His symptoms include :

    – has major distrust in people (even me! always snooping around my phone and computer!), very moody, anger issues, always accusing me of things
    – paranoid/delusional/unreasonable thoughts (thinks i am seeing other men)
    – borderline personality disorder (fear of abandonment), post-traumatic stress disorder
    – poor memory
    – his negative thoughts would previously cause bad vivid dreams. After breaking up with his last girlfriend two years ago, he would have very disturbing dreams, thrashing around with raised body temperature in the middle of sleep.
    – when he is stressed he scratches a lot, and always has dry skin falling everywhere he goes
    – has eczema, grinding teeth, ringing in ears, sleep paralysis
    – food intolerances causing diarrhea, food allergies
    – had gout, procrastination, brain fog, gallbladder clogged up but improved with detox

    His symptoms above improved after taking the anti-parasite medication Abendazole for 2 weeks. So we know he also has a lot of parasites. He is also now taking Triclabendazole, Ivermectin, Praziquantel, etc and we also think he has Lyme Disease as his “negative thoughts” and itchiness are still there.

    What supplements should he be taking? What do having all 3 BHMT homogeneous mean? Here are his 23andMe results below :

    #377898 Reply


    Darn, the images didn’t show up.

    My homozygous mutations :

    VDR Taq

    My heterozygous mutations :

    MTHFR A1298C
    COMT P199P
    MAO-A R297R
    MTRR A66G
    CBS A360A

    My boyfriend’s homozygous mutations :

    VDR Taq

    My boyfriend’s heterozygous mutations :

    MTHFR A1298C
    MTRR A66G

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