This topic contains 4 replies, has 1 voice, and was last updated by Myrtlemog 1 month, 3 weeks ago.
November 2, 2012 at 10:50 pm #4278
I was curious if you knew of any relationship with the c677t mutation and Cystic Fibrosis. My youngest daughter was diagnosed at birth with Cystic Fibrosis. Her mutation is the most common CF mutation (Double Delta F508). This summer, after a pulmonary embolism landed me in the ER, I was diagnosed as being homozygous for the c677t MTHFR mutation. As a precaution, we had both of my children tested to determine if they had it as well. Of course, the one who already has one genetic disease is the one who turned out to be homozygous for the c677t MTHFR mutation as well. Have you ever heard of a correlation between CF and a MTHFR gene mutation? We are setting up an appointment with a hematology specialist for advise on how we will need to address this additional complication to her life. If you have any advise or know of someone who might have some experience with both of these mutations, I would appreciate any advise we can get.
Thanks!!December 27, 2012 at 11:40 pm #5850
I’m far from an expert but did some research a while back on MTHFR. I do recall that the MTHFR mutation needs to be taken into account when drug dosing. There is an article entitled ‘Understanding the Clinical Utility of MTHFR Gene Testing for Chronic Disease Management’. This article states: ‘… Knowing an individual’s MTHFR 677C>T genotype can provide important clues not only in the treatment of patients presenting with hyperhomocysteinemia, but also in understanding patient response to medication dosages. There is evidence to suggest that medications affecting folate metabolism, e.g. bile acid sequestrants, antacids, oral medications for diabetes, certain types of chemotherapy and H2 blockers, may be more toxic in MTHFR mutation carriers than non-carriers4-7.’. Here is the article: http://www.hdlabinc.com/sciencebulletin/Clinical-Articles/the-clinical-utility-of-mthfr-gene-mutation-testing As a side note I remember hearing that some people react adversely to chemotherapy, in particular they have extreme lung injury, and doctors do not know why. I wondered if the MTHFR mutation could be affecting those people but they and their doctors are unaware of the connection. I hope this is helpful to you.December 28, 2012 at 12:35 am #5851
The fluoroquinolone antibiotics can cause damage to tendons in some users. I’ll bet they are MTHFRers because they cannot detoxify well. I have some damage myself after taking Levaquin two years ago; I am still feeling effects.January 2, 2013 at 12:39 am #5906
I am 54 years old and have the MTHFR c677t genetic defect. My brothers also both have it. One brother and myself have had multiple (many) blood clots and are on coumadin for life. I also was diagnosed with Fibrosis in my lungs and a mycobacterium infection and am suspecting some version (milder) of adult CF. Sounds crazy, but more adults are first being diagnosed with milder versions of cf in adulthood. I also have scoliosis with a Harrington rod in my back. I am currently researching the connection between CF and this genetic defect, if any. I have trouble with many medications and am now suspecting this may play a part. My doctors do consider this a genetic clotting disorder. Hope this info helps you in some way. Wishing you all the best and good things in the future.February 1, 2015 at 9:45 pm #528692
dvd disks philips
coffee pod machines review
coffee machines for businesses
luminous philips magazine
bean to cup coffee machines
coffee brewing machines|
espresso coffee machines manufacture gmbh|
The actual title states every thing. This is actually the greatest on the internet pharmacy on the web. The actual catalog web page is placed showing probably the most polular ERECTILE DYSFUNCTION products, as the menus as well as quicksearch permit to find items within additional groups.
Cialis Levitra Expert Cialis Soft TadacipВ® Test Packs AvanaВ® KamagraВ®Oral Jelly E mail us CialisВ® Home KamagraВ®Soft SilagraВ® Viagra Extremely Active Super AvanaВ® Levitra Extremely Force Levitra Levitra Dental Jelly Levitra Gentle Viagra Soft SuhagraВ® Guidelines CavertaВ® Cialis Extremely Active About All of us ApcalisВ®Oral Jelly Cialis Extremely Force TadalisВ®Sx Viagra Woman Cialis IntagraВ® Kamagra Effervescent Monitor Order ViagraВ® LevitraВ® KamagraВ® EriactaВ® VigoraВ® Desire to get free test pills? It’s simple! Placing an purchase for 60 or even more pills of universal ED medication as well as generic Propecia, you’re going to get 4 Viagra tablets or 2 Cialis pills like a free bonus for your order. Just choose the medication you want to receive as an example while ordering.
viagra sildenafil,generic viagra sildenafil,buy viagra sildenafil,viagra sildenafil online,cheap viagra sildenafil,buy viagra sildenafil online,viagra sildenafil alternatives,cheap generic viagra sildenafil,viagra sildenafil side effects,order viagra sildenafil online,free viagra sildenafil samples,pharmacy, online pharmacy,cheap pharmacy,cheap online pharmacy,pharmacy store, pharmacy shop,cheap drugs,cheap pills,generic drugs,drugs discount, lowest prices,online drug store,social pharmacy,fast delivery