calcium folinate

In terms of the Metafolin – I took roughly 15mg as part of an active b complex. I felt really off that day. Additionally – I tried about the same in terms of the Calcium folinate about a week ago and had similar results, which seems to be lasting much longer. I haven’t felt the same since – I feel quite ‘heavy’ – almost like my nervous system has been suppressed. However, I have an underlying feeling of anxiety – which actually resulted in a panic attack yesterday. I get the feeling that active folate is really bad for me. This is from my lab results:

The (-) indicates homozygosity or unidentified
allele.
Typing performed by PCR and hybridization with
sequence specific oligonucleotide probes (SSO).
METHYLENETETRAHYDROFOLATE AMD
REDUCTASE (MTHFR), DNA
RESULT see note
POSITIVE FOR ONE COPY OF THE C677T MUTATION
INTERPRETATION see note
This individual is heterozygous for the C677T
mutation and negative (normal) for the A1298C
mutation in the MTHFR gene. Heterozygotes may
have intermediate levels of enzyme activity, but
no increase in plasma homocysteine levels that has
been correlated with coronary artery disease and
venous thrombosis. Increased risk of coronary
artery disease, venous thrombosis and increased
plasma homocysteine can be caused by a variety of
genetic and non-genetic factors not screened by
this assay. Consider genetic counseling and DNA
testing for at-risk family members.

Thank you so much for your help – the anxiety/panic has a pretty strong hold on my life right now.

Zac –

You have one copy of C677T which means you are able to make methylfolate – just not as easily if you did not have the defect.

You may have some other genetic defects which reduce your body’s ability to eliminate neurotransmitters – MAO A and COMT. If this is the case, methylfolate can definitely make you feel not good.

Get on some niacin right away as that will help offset the symptoms you are feeling now.

Consider swallowing 1/4 of a tablet of time-released Niacin twice daily.

You may feel a flush but that will go away in about 20 to 30 minutes. Taking only 1/4 tablet will help reduce the chance of flushing. This is a time-released niacin so that also helps reduce flushing.

Try to get up to 500 mg twice a day – which is 1 tablet twice daily. Niacin can be brilliant for anxiety.

Eating every 2 hrs with some form of protein is also critical – along with eliminating gluten and dairy as they are excitatory neurotransmitter-forming.

Sorry – one more thing to mention – the b-complex that makes me feel great… has the following in it:

Niacin (from inositol hexanicotinate 34 mg, niacinamide ascorbate 30 mg, & nicotinamide adenine dinucleotide 10 mg [Coenzymated™])

Can I just take that and get the time-released niacin – when that bottle is empty (which will be quite soon).