Dawn Wolf
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My brother-in-law was recently diagnosed with MTHFR homoygous for a1298c and was told he would stay on Coumadin the rest of his life. He has two daughters which I understand must at least be MTHFR heterozyous and also a mother that is still alive that would also be! He commented that his doctor told him that there are no concerns with being heterozygous a1298c, but from the information I can find online I believe the girls should be tested and check more into it. What are the issues if one is MTHFR hereozygous for a1298c?? My understanding is that it is not as clinically bad as being homozygour, but what are his daughters to watch for. My husband is getting test soon and the same questions would apply to my family too.
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Dr Ben
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Dawn -
Your husband does not need to be on coumadin if he only has the homozygous A1298C MTHFR mutation. He may have other needs for coumadin but this alone does not necessitate a need.
You are right – 2 copies (homozygous) is more serious than 1 copy (heterozygous).
If your husband is moody, cannot sleep, addictive behaviors or has nerve problems, these are signs that the MTHFR mutation is affecting him.
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Dawn Wolf
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Thanks Dr. Ben for your quick reply! If the symptoms of abnormal sleep, and anxiety/nerve problems does occur. We notice these in our young 10 yr old daughter and if she tests positive to Mthft issues, could vitamin supplementation help? B6 and B12? She is presently on Zoloft and we are hoping she doesn’t need it life long? Any thoughts? We are going through the testing process, but wondering if there is hope for other treatment other than Zoloft.
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Dr Ben
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Dawn –
If your daughter has those symptoms, she can improve regardless of MTHFR or not.
If she has MTHFR – and she at least has one copy of A1298C (because her father has two copies), then that will affect her neurotransmitters – yes.
Methylfolate, B6, methylcobalamin are all excellent typically for those with MTHFR – especially C677T forms.
The A1298C mutation is not about methylfolate – it is more about reducing inflammation, improving digestive flora, reducing ammonia levels and increasing levels of BH4.
Zoloft is not a permanent requirement here – and in my opinion – never is. Zoloft does not address underlying issues – and underlying biochemical issues can be fixed with diet, lifestyle and nutrients.
Once you get the results in, please schedule a consult and we’ll get her squared away  Please call 800-547-9812 when you’re ready.
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Sophie
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Hi Dr. Ben,
How does one go about reducing inflammation, reducing ammonia levels and increasing levels of BH4?
I too have Heterozygous A1298C mutation and had 2 miscarriages. In what way does this mutation affect pregnancy, and what supplements can improve the outcome?
Thank you!
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