Increased chance of other MTHFR mutations when SNPs of 677 and/or 1298 exist

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This topic has 2 voices, contains 1 reply, and was last updated by  Dr Ben 81 days ago.

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February 21, 2012 at 3:15 am #972

Michael

Dr. Ben:
I’d like to know, based on your educated opinion as well as on factual data whether individuals who have mutations of the 677 and/or 1298 location of the MTHFR gene are more likely to have other mutations in other locations of the MTHFR gene. If so, do you consider it likely that there is a direct correlation between those with more mutations at OTHER not generally tested locations and the severity of one’s symptoms? For the record, I am heterozygous for both a1298c and c677t, and I’m receiving very noticable benefit from 800-1200 mcg of metafolin.
February 28, 2012 at 8:09 am #1086

Dr Ben

Hi Michael –

There over 40 different SNP’s for the MTHFR gene but only 2 appear to be the most problematic.

Research focuses on these two SNP’s because they appear to cause the most significant symptoms.

That said, if you do have other variants, it does not matter – at least with our present knowledge.

I am pleased to hear you are getting better with methylfolate :)

Keep in mind that you should obtain methylcobalamin (active B12) from your diet (grass fed meats) in order to keep the methylfolate working. If you do not maintain sufficient B12 levels, the methylfolate will not work nearly as well as it will get ‘trapped’

Consider taking 1 tablet of Active B12 with Methylfolate upon waking in the morning. It is sublingual.
It provides 800 mcg of methylfolate and 1 mg of methylcobalamin.
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