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This topic has 2 voices, contains 5 replies, and was last updated by  Sophie Roz 82 days ago.

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February 5, 2012 at 3:46 pm #729

SaraB

Hi Dr. Ben.

I was diagnosed recently with homozygous c677t MTHFR as well as a “4G/5G variant” (can’t find anything out there on that) after a miscarriage at 14 weeks. I have had three other very early miscarriages and two healthy pregnancies. My question is about where to go from here. I was able to talk my Dr. into giving me an Rx for Cerefolin and so right now I’m taking that plus 2,000 IU of D3 and a prenatal that does not contain any form of folate . My midwife wants me to start on Lovenox right away, but I have read there is a link between Lovenox and autism. It is also my understanding that there is a lot of doubt as to whether or not Lovenox makes a difference in pregnancy outcomes.

What is your stance on Lovenox? Are there more natural alternatives?

Is Cerefolin a good thing for me to be on? What should I be on?

What is a 4G/5G variant?

Thanks Dr. Ben!

February 5, 2012 at 7:26 pm #731

SaraB

Forgot to include: I am currently 5wks pregnant, hence the midwife wanting me on Lovenox.

February 8, 2012 at 7:09 am #756

Dr Ben

Sara –

I have not heard of Lovenox causing autism. The MTHFR gene mutation is what sets one up for autism if not addressed properly.

I am for Lovenox currently. Nattokinase is also effective but you cannot mix them – it is one or the other. Also – Lovenox has research supporting it while nattokinase doesn’t have much.

Please read this article:
http://mthfr.net/prenatal-supplementation-optimizing-your-future-child/2012/01/20/

I do not know what that other variant is. There are many other MTHFR variants and only two are really somewhat understood – A1298C and C677T.

Cerefolin is good if it is without NAC. I don’t recommend that much NAC while pregnant. There are studies that show NAC is not good to take while pregnant – at least in higher amounts.

Metanx is quite good. Homocystex is also quite good.

Or you can use straight L-5-MTHF with some additional sublingual methylfolate and methylcobalamin and a multivitamin with methylfolate as well. All described in the article.

February 9, 2012 at 3:43 am #760

Lori

Hi Dr. Ben,
After two devastating miscarriages I was diagnosed with compound heterozygous mutation: MTHFR 677CT + MTHFR 1298AC. I am current taking 2 folgard 2.2 daily, 1 Neevo (combo pack) daily and 1 baby aspirin daily. I also already have on hand Lovenox 30mg to be injected daily with first positive pregnancy test (if I get pregnant again). I have been seeing my regular OB/GYN and also have a Maternal Fetal Medicine doctor. I would love any advice/suggestions you may have on my medications. Am I doing the proper things to have a successful/healthy pregnancy?
Thank you,
Lori

February 14, 2012 at 7:54 am #835

Dr Ben

Hi Lori –

I recommend you read this article on Prenatal Supplementation.

I do not recommend Folgard as it contains the inferior forms of folate, B12 and B6.

Taking something like Optimal Multivitamin along with HomocysteX or the Active B12 with Metafolin is more effective as they contain the most active forms of these esseential nutrients.

February 27, 2012 at 5:29 am #1071

Sophie Roz

Hi Dr. Ben,

I just learned that I have MTHFR A 1298C gene mutation (heterozygous). My homocysteine level is 8.
I also have positive ANA – 1:80 HI. I don’t have lupus or any other autoimmune disease. All blood clotting workup came back negative.
I’ve had 2 miscarriage, a year apart. Fist was a partial mole. The most recent one was in the 2nd trimester after what seemed to be a normal pregnancy. I do have two healthy kids, the youngest is 8 years old. My first two pregnancy were normal and I was not on any meds.

My doctor plans on prescribing Lovenox if I conceive again.
I cannot take baby aspirin due to gastritis (I’ve tried and experienced severe stomach pains).

I was wondering what would be the best way to address the gene mutation coupled with positive ANA and hopefully go on to having a healthy pregnancy?
Can I try to conceive now (and begin taking MTHF), or does trying to conceive without having prior taken methylfolate poses risks of more miscarriages or birth defects? If so, how long do I have to be on it before we can try to conceive?
What is the difference between 5-MTHF and L-5-MTHF?

Thank you so much for your time!
Sophie

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