Swanson Homocysteine Formula?

This topic contains 20 replies, has 1 voice, and was last updated by  Hassie 9 months, 1 week ago.

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  • #6518 Reply


    I received a new Swanson Health Products catalog a few days ago, and noticed that they have an activated homocysteine formula that contains B-6 (as pyridoxal 5-phosphate), 800 mg of folate in the form of 5-methyltetrahydrofolic acid, B-12 as methylcobalamin and 500 mg TMG (Trimethylglyceine from natural Betaine). Here is the link: https://www.swansonvitamins.com/swanson-ultra-activated-homocysteine-formula-60-veg-caps.

    Does anyone know if this is OK?

    I’m on Thorne Prenatals, but if hubby (just tested) also has an MTHFR mutation, I’m wondering if this would be a well-rounded supplement for him. (The kids probably have at least one mutation, so will go on Thorne children’s vites as the Seeking Health version does not seem to sit well with their tummies.)

    Other suggestions are welcome!

    #6523 Reply


    Hi Claire
    I am sure a lot will depend on the individual – whether they are able to tolerate going straight in with a multi, or whether they need to add in one supplement at a time, gradually, as advised in the C677T protocol article. I would suggest you check it out if you haven’t already.

    All the best, Allie

    #6526 Reply


    Thanks Allie,

    Thanks so much for your reply. The cautious approach is probably the better one in this case, as he is prone to migraines. We also found out the results today. Like me, he is compound heterozygous. Guess it’s definitely time to have the kids tested, too.

    I’ll re-read the C677T protocol, as that’s in the mix.

    #6527 Reply


    Also, comments since Dr Ben posted the C677T protocol have shown that it is the starting point for all of us.

    #6536 Reply


    I think I’ve figured it out for DH, but now the kids, who must be (in the best case) compound heterozygous, but possibly homozygous for either mutation.

    I’ve noticed that for folate, the Thorne vitamins contain 200 mcg as Calcium Folinate and 200 mcg as 5-Methyl-tetrahydrofolate. The B-12 is a similar mix: 67.5 mcg as Adenosylcobalamin and 67.5 mcg as Methylcobalamin. I am wondering if this mixture (also in my prenatals) could be a problem?

    Looking into calcium folinate, I find that it is not recommended for those with homozygous mutations, but probably not an issue for those with heterozygous mutations. (But what about compound heterozygous??)

    Ack – well, guess I kind of answered my own question here: it’s safer to go with the pure 5-Methyltetrahydrofolate and Methylcobalamin for the kids (i.e. not use the Thorne vites at this time). But for me…being compound heterozygous, will that mixture be OK? Yikes.

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