With any craze, crazy things can happen.
I am seeing MTHFR mutation information skyrocket (which is awesome!) and new supplements designed for MTHFR mutations appear overnight (which is also awesome!).
However, I am a bit uncomfortable:
Merck, the patent holder of Metafolin, does not allow dosing of Metafolin to be greater than 1,000 mcg and most often they do not allow over 800 mcg.
I’ve confirmed this with my manufacturer who works with Merck directly.
There are only about 3 manufacturers in the USA who are allowed to use Metafolin – the real one – and I contract my supplement development with two of these manufacturers.
Now if a product states it has over 1,000 mcg of Metafolin in it, it doesn’t mean that it is inferior to Metafolin. It simply means that they are not using the true Metafolin.
Letting you know – careful.
From my manufacturer:
Hi Dr Lynch,
I was shocked by this also, found out about it last week. BUT be clear it is NOT Metafolin, it is a L-5-MTHF knock off and appears to be currently legal.
BUT I also dont see this staying in the marketplace too long. I was unaware that the restrictions on folate dosages had been lifted! Apparently they could sell a 20 mg Folate cap if they wanted.
Sooner than later I would suspect a FDA crackdown.