Metafolin Knock Offs – Caution

With any craze, crazy things can happen.

I am seeing MTHFR mutation information skyrocket (which is awesome!) and new supplements designed for MTHFR mutations appear overnight (which is also awesome!).

However, I am a bit uncomfortable:

Merck, the patent holder of Metafolin, does not allow dosing of Metafolin to be greater than 1,000 mcg and most often they do not allow over 800 mcg.

I’ve confirmed this with my manufacturer who works with Merck directly.

There are only about 3 manufacturers in the USA who are allowed to use Metafolin – the real one – and I contract my supplement development with two of these manufacturers.

Now if a product states it has over 1,000 mcg of Metafolin in it, it doesn’t mean that it is inferior to Metafolin. It simply means that they are not using the true Metafolin.

Letting you know – careful.

From my manufacturer:

Hi Dr Lynch,

I was shocked by this also, found out about it last week. BUT be clear it is NOT Metafolin, it is a L-5-MTHF knock off and appears to be currently legal.

BUT I also dont see this staying in the marketplace too long. I was unaware that the restrictions on folate dosages had been lifted! Apparently they could sell a 20 mg Folate cap if they wanted.

Sooner than later I would suspect a FDA crackdown.

Dr Ben

8 Responses to “Metafolin Knock Offs – Caution”

  1. Fran July 9, 2014 at 9:02 pm #

    Today, Cerefolin NAC delivers: 5.6mg L-methylfolate as Metafolin, 2mg B12, 600mg N-acetylcysteine

  2. Mary holmes April 28, 2015 at 1:20 am #

    I have been taking Thorne 5-mthf 5mg for several months; I developed a pink rash that is extremely itchy. I read an article you wrote about folate causing a rash and would like to confirm exactly what rash you were talking about. Could this reaction be caused by a “fake” folate and which folate should I be taking or did this rash mean that I am allergic to folate. Lastly I am finding it extremely difficult to find a MD in my area who is knowledgeable or willing to learn about A1298C to help me and my family

    • Aron May 7, 2015 at 5:28 pm #

      Hi Mary – A rash can be a side effect of taking 5-MTHF. I cannot speak to the quality of this specific Thorne product, but they are a well-respected brand. It is possible that you are taking too much and/or too often. See this post addressing Methylfolate Side Effects (

      More doctors are completing Dr. Ben’s training everyday. You can check the Physician Directory ( to look for a practitioner in your area. If there are none in your area, there may be some who are willing to do phone consults or can point you in the right direction.

      Best of luck,

  3. Joan August 5, 2015 at 10:37 pm #

    Hello Dr. Ben. I recently filled a script for a generic version of L-Methylfolate that I want to ensure is legitimate. The package calls it “L-Methylfolate Forte 7.5 mg” and the insert label says that each capsule contains 7.5 L-Methylfolate as Metafolin AND 90.314 mg Algae-S powder (Schizochytrium). It is manufactured by Nestle Health Science, distributed by Breckenridge Pharmaceutical. Is this a true generic for Deplin? If so, why is everyone paying the Deplin prices? Thank you.

  4. kia April 22, 2016 at 8:13 pm #

    The ingredient in those is probably Quatrefolic (glucosamine salt of (6S)-5-methyltetrahydrofolate), which appears to be as effective as Metafolin. At least the EFSA (Europian Food Safety Authority) thinks so. You can search the paper by EFSA. It’s somewhere on their website. Use google.

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