Methylation and MTHFR Defects: Presentation

34 Responses to “Methylation and MTHFR Defects: Presentation”

  1. Linda Czarniecki April 25, 2012 at 9:20 pm # Reply

    I would like to start testing in all these areas. I already know I am homozygous A1298c. How do I get started on your protocol Dr. Ben?

    • Dr Ben April 25, 2012 at 11:07 pm # Reply

      Hi Linda –

      As mentioned in the presentation, I work from a multifaceted approach. MTHFR A1298C is one of the factors involved but not the main issue for most individuals. That said, I recommend scheduling a consult to go over ‘your’ personal concerns and symptoms and we can see what to do about them through lifestyle and diet – along with recommended supplementation.

      Starting with Methylcobalamin is a great start – I do talk about the A1298C defect in this presentation along with things I commonly use for it – and how I start.

      Please do watch it in full – it is an investment and will take 1.5 hrs of your day but if you watch it in full, you’ll see how it all relates together making it that much clearer for you.

  2. Linda Czarniecki April 25, 2012 at 9:40 pm # Reply

    Dr. Ben, I hear you talking about Krill Oil but I have had a bad reaction to krill oil. I get severe stomach issues. Is regular fish oil okay?

  3. Linda Czarniecki April 25, 2012 at 10:08 pm # Reply

    What if you are addicted to klonopin. Can that be helped?

    • Marie October 20, 2012 at 12:27 am # Reply

      Hi. Linda. My doctor has me taking Valium to ease off of Klonapin more slowly. This eases the withdrawal symptoms because it comes in smaller doses and it has a longer half life.

  4. David April 26, 2012 at 4:41 am # Reply

    very nice summary, thank-you.

  5. nicole April 26, 2012 at 7:40 am # Reply

    Very helpful information Dr. Ben. Now I know why my folate lab level was through the roof prior to being Dx’d with MTHFR defect. Being compound heterozygous (kind of feels like I’m a 3 headed mutant :)) but things really are making alot of sense and this presentation answered many questions! Like when I added the B complex and felt like garbage :( I am taking things slowly, working on the gut too. Getting better every day! Thank you!

  6. Helen Janneson Bense April 26, 2012 at 4:47 pm # Reply

    Thanks so much Dr. Ben. I thoroughly enjoyed this very well researched and informative explanation of methylation. It really clarified a few things up for me that I had been pondering about – folinic acid, B3 and totally agree with you on the hair analysis. I’ve learnt a few new things tonight at this very late hour here in Aus, but it was well worth the watch. Keep posting these great videos. Many thanks, Helen :)

  7. Sterling April 27, 2012 at 5:12 am # Reply

    Excellent presentation Dr. Ben. Adding it to my website.

  8. Kathy April 29, 2012 at 4:37 pm # Reply

    Dr. Ben,

    Thanks for this very informative presentation. Being homozygous 677 leaves me with many question which you have been helping me with since I found I can see I will have to watch the presentation a few times to really get the most out of it. Keep up all your good work!!! We all need it!

  9. Lisa Bowman May 1, 2012 at 9:25 pm # Reply

    Dr. Ben,

    Wow! Such an informative presentation. Wished I would have seen it yesterday before I took the folinic acid prescribed for my son’s pyroluria. (Yes, I have it too and I take everything he takes to understand what’s going on.) He’s doing well. I’m miserable and experienced almost every single one of the side effects you listed. I’m pretty sure we have mutations. I have corrected many of my health problems with diet, supps and lifestyle. And yes, hydroxy B-12 does clear your head from nitric oxide. That has given me huge relief. Things were pretty great for me until the folinic acid. Never again! I did start slow. Took 170 mcg. Yesterday I was running around like a young pup. Today I can barely lift my feet. Think these doctors cause CFS or make it worse. Thank you!

  10. babyfoodsteps May 2, 2012 at 7:49 pm # Reply

    This is a wonderful presentation and gave ae ALOT of clues why my 3 year old acted how she did (psychotic and like a caged animal) when we tried to supplement her with folate.
    I am curious if you have any resources for testing the 12 or so “other” genes you discuss around the 19 minute mark of the talk. Thank you in advance.

    • Dr Ben May 3, 2012 at 7:04 am # Reply

      Hello –

      Only resource at the moment for testing some of those genes is via Dr Amy Yasko and her Methylation Genetic Test. I am working on making one myself but it is not yet done being validated. The test I am preparing has some genes which I feel need to be tested for that are not included in Yasko’s – and I feel she has some genes which are not needed to test for; however, we do work in different populations so that is the reason.

      Use my name – Dr Ben Lynch – and I believe they will cut you some slack in the test pricing – I hope so.

      • Marie August 30, 2012 at 5:08 pm # Reply

        You mention Amy Yasko’s genetic test, but there’s also the DetoxiGenomic Profile

        There’s also 23andMe, which does genetic testing as well.

      • Paula Thomas October 17, 2012 at 7:53 pm # Reply

        Has your panel of genetic tests been validated yet? I’m interested in getting some gene testing done.

  11. V. McKenna May 9, 2012 at 3:00 pm # Reply

    Dr Ben,

    Great presentation! Thanks for sharing it; lots of great information.

    On the slide where you list how you treat each mutation, you start all with SL Methyl B12 1,000. I checked your website,, but didn’t see a SL Methyl B12 1,000 (without Methyl Folate); I only saw one with 5,000.

    Do you recommend splitting the SL Methyl B12 5,000 pill or do you recommend another product?

    I’m hetero A1298C and am looking to see if some of my health issues improve with your standard protocol.

    • Dr Ben May 9, 2012 at 4:46 pm # Reply

      Hello –

      I recommend splitting the Active B12 5000 tablet into fifths – or quarters. They are very easy to break apart.

      Remember to address the digestive system and your environment as well ;)

      Look forward to hearing your progress.

      If you get stuck, I’m here if you need me. I am available for consults should that need arise.

  12. Jared May 21, 2012 at 10:30 am # Reply

    I looked back on a past blood test I had done and it showed, at least from my understanding that my MTHFR was homozygous normal. Are there other things that I can get tested to see what may be causing methylation issues or other problems? So far my naturopathic doctor has determined I have non alcoholic fatty liver disease and thyroid issues as well, and has me on some medications and supplements.

    • Dr Ben May 21, 2012 at 6:23 pm # Reply

      Hi Jared –

      It depends on what the symptoms are. I don’t like people running out and ordering expensive lab testing when all it will show is: “normal”, “normal”, “slightly low”, “slightly high”

      That is frustrating and expensive.

      What I recommend instead is working with your doctor on the foundational things first:
      – diet
      – lifestyle
      – gut health

      If you are not addressing those full-on, then you’ll not get better.

      There are many things to do for NASH (fatty liver) and thyroid disorders.

      If you feel you need my support, you may schedule a consult by calling 800-547-9812 or beginning the RSVP process online here.

      If you do want to order methylation testing, this is the methylation test profile that I do recommend.

      In health,
      Dr Ben

  13. Lea June 27, 2012 at 3:52 am # Reply

    Hi Dr. Ben,

    I have two copies of the C667t. Iv’e been supplementing B-12 even before i knew I had the MTHFR because my levels were low. I had one very very early pregnancy loss last year. I am now pregnant again. The Dr has me on Neevo DHA which has the L methlyfolate, and baby aspirin and they want me to to start lovenox soon. I also have two other clotting factors, I believe Anticardiolipin and one other.
    I want to do whats best for myself and my baby. What do you recommend?

    I should tell you my folate and homocystine levels are normal according to blood work.
    I appreciate any of your advice.

    • Dr Ben June 27, 2012 at 5:28 am # Reply

      Lea –

      Glad your doctor is being proactive.

      I believe you should be monitoring your hormone levels – esp progesterone.

      A consult is highly recommended here to go over your individual circumstance in order to optimize the outcome.

      I do not take much stock in normal homocysteine levels and folate levels are also not that important of a marker.

      I highly recommend testing for:
      – female hormone levels
      – D3
      – serum ferritin
      – TSH, T3, T4, anti-TPO, anti-TG

      I’d consider getting on the Lovenox right now.

      Please read this post on recurrent miscarriage and MTHFR

      This article may also be useful on prenatal supplementation for women having MTHFR mutations.

      If you’d like to schedule a consult to discuss, please do call 800-547-9812

      For inspiration, I highly recommend watching the video by Bruce Lipton, PhD – called ‘The New Biology’

  14. Lynn D August 9, 2012 at 6:00 pm # Reply

    Thank you for the information and presentation. saw another Dr also had one that said
    his parents grew raspberries that are high in active folate which helped there genetic type. learning about MTHFR. found it while doing websearch on whymy folic acid levels were so high when they tested my blood (also carotene high), B12 was normal. Dr prescribed me MB12 which helped immensley . Also trying to track why Meibomian gland problems with eyes and wondered if related to heart issues MTHFR people get (fat gets thicker ).Also if might help reduce the Dupretures lately told have. Last year found if stopped cheese (cheddar), then brain seemed to work a little better (was listing).
    Since both sons were checked for joint hypermobility problems (they said not Marfans).
    Also thinking the one you mentioned with NOS sounds like might help to test for us as we have low blood pressure that all got worse after lo level CO exposure.
    Thanks for info, as wondering about the high folic acid levels and other related items.
    Lynn D
    remember to take good care of your self (does your family also have any of these genetic variance?)

  15. Summer Bonnet August 14, 2012 at 6:05 am # Reply

    I have had three miscarrages. I have tested positive for the C677T heterozygous, my husband has tested positive for the A1298C heterozygous. I have purchased the recommended suppliments, 2.Sublingual Active B12 with Methylfolate: 3.L-5-MTHF plus others.
    I have just found out my husband may have haemochromatosis – would this also impact on the miscarrages or cause other problems.
    Thanks for your help

    • Dr Ben August 17, 2012 at 7:25 am # Reply

      Hi Summer –

      Your husband’s hemochromatosis may or it may not – I suspect not. Please get him to donate blood regularly along with taking Rutin.

  16. Catherine August 19, 2012 at 2:56 am # Reply

    Hi Dr. Lynch,
    I am so thankful to have found this website, and find some solid information regarding MTHFR.
    I have 3 healthy children, age, 8,6, and 4. But since my last child, I have lost 5 babies (one twin pregnancy at 20 weeks.) I am heterozygous for MTHFR, C667t. I also was told I have 3 other clotting disorders; PAI-1, HPA-1, and Factor XIII. I just lost my last baby in June, at 12 weeks, and I was taking baby aspirin, and 30 mgs.of lovenox twice a day during this pregnancy.
    I feel like there is a piece of this puzzle that is missing as to why we have lost these babies, and I am so hoping to figure out what it might be. I have started taking Metanx now, but after I lost the baby. I would love to hear what supplements you think I should be on, how much methylfolate I should be taking, and if you know much about these other clotting disorders?

    Thank you so much.

  17. Julie Mansfield November 6, 2012 at 4:54 am # Reply

    Hi Dr Lynch,

    I’m in Australia & have tested negative to the MTHFR – A1298C & C677T. I have Hashimoto’s & wanted to test further the MTR/MTRR & HNMT because I am always low in B12 & turn bright red when I first drink alcohol.

    The 2 pathology labs I’ve been to don’t recognise these tests. Could you tell me if these tests are known by another code, as my Dr knows very little about this. Or can you guide me to somewhere I can find out?

    Thankyou, Julie


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