Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take. The issue is methylfolate can cause more harm than good if not started at the right time or tapered up slowly in amount.
UPDATE December 7, 2014:
Please read this article on how to prevent methylfolate side effects in addition to this one. I’ve since learned how to reduce the incidence of side effects even more.
There appear to be three types of responses to methylfolate:
FIRST: A person who can jump on methylfolate and feel absolutely wonderful. The only down side they experience is why didn’t they know about methylfolate before?!
SECOND: A person starts methylfolate has an amazingly incredible week where they are happy, interacting and alert. Then the second week comes and they switch to wanting to hide in a room by themselves or literally throw dishes across the room out of anger. Or they may become bed ridden from muscle aches, intense headaches or joint pain.
THIRD: A person takes a small amount of methylfolate and feels all the methylfolate side effects right out the gate.
Methylfolate Side Effects:
- sore muscles
- achy joints
- severe anxiety
Why does methylfolate create such an amazing week and then create such severe side effects so soon after?
It has to do with methylation, pre-existing inflammation and other genetic mutations which exist yet you’ve no idea they do.
This gets complicated quickly so I am going to keep it simple.
If you experience any of the above methylfolate side effects, I highly recommend you discuss it with your physician and get your dose of methylfolate reduced significantly or stopped for a week or two before reintroducing it.
UPDATE November 25, 2014
two three four things you can do to quickly quench most of the methylfolate side effects:
- Consider 50 to 100 mg of niacin as nicotinic acid. Why? Niacin is broken down by SAMe. This means that excessive SAM is quenched by taking niacin. Niacin also helps transform folates – especially unreduced folates. There are many other things niacin does as well – beyond my understanding. I continue to look for them and will update this as I learn more.
- NOTE: You may experience flushing for 20 to 30 minutes. This is not harmful. It simply makes you feel ‘warm’ everywhere.
- Consider 1 to 2 capsules of 250 mg of liposomal curcumin to help quench inflammation. If one takes methylfolate before inflammation is controlled, the methylfolate will worsen it. One may consider taking 2 capsules of Optimal Turmeric three times a day during times of inflammation.
- Consider Hydroxocobalamin as it is an excellent sponge for reducing nitric oxide levels. Methylfolate increases nitric oxide levels – which is why it is so effective in reducing headaches, pain, cardiovascular disease risk, thrombosis, preeclampsia, periodontal disease, etc – but at the same time, excessive nitric oxide levels are harmful as they end up producing serious radical damage via peroxynitrite. Hydroxocobalamin quenches nitric oxide quite effectively. Hydroxocobalamin also works to reduce hydrogen sulfide levels (great for those with high sulfate-reducing bacteria or sulfur-smelling stools/diarrhea).
- Limit intake of leafy greens until side effects go away. This is because leafy green also contain methylfolate and nitrates.
- Electrolytes – as methylfolate increases, so does cell division and when that happens, electrolyte deficiency can occur. Taking Optimal Electrolyte helps knock out some of these side effects. There is also some niacin in the electrolyte blend.
- Glutathione – as cells divide with more methylfolate, glutathione levels get further depleted. Restoring levels can help significantly. Do it SLOWLY though. Consider Optimal Liposomal Glutathione.
Questions for you to answer in your comment below – and please do – be sure to state which MTHFR mutation you have:
- What methylfolate side effects have you experienced?
- Did the niacin, hydroxocobalamin and curcumin help you resolve your methylfolate side effects?
- Did you suffer through the initial methylfolate side effects only to come out feeling great in the end? Or worse?
- Did your doctor start you on a 1 mg or more initial dose of methylfolate and that set you off?
- Did your doctor taper you up gradually and slowly on methylfolate? How’d that work for you?