MTHFR and Meningioma – Question

Question:    I thought I saw a connection to MTHFR & meningioma somewhere that you wrote about or linked, but I cannot find it now. anyway my daughter who is 15 has a meningioma and my baby ( my 8th child) has down syndrome, so I have been thinking about getting tested and in the meantime we are all taking folate (not folic acid ) supplements. I don’t have insurance and my daughter has medicaid so I would have to pay for the test. If Iam positive then I can tell her dr. and they will test her too.

I really need someone to help us through this, do you know if there is anyone practicing in south Florida who has a “clue” about MTHFR? I appreciate all the info you have here and how you care to educate us all 🙂 all the best.

Answer: Yes, there is a connection between meningioma and compound heterozygous MTHFR and homozygous C677T mutations.

The highest risk of meningioma was associatedwi th heterozygosity for both MTHFR variants [odds ratio (OR), 2.11; 95% confidence interval (95% CI), 1.42-3.12]. The corresponding OR for glioma was 1.23 (95% CI, 0.91-1.66). A significant association between risk of meningioma and homozygosity for MTRR 66G was also observed (OR, 1.41; 95% CI, 1.02-1.94). Our findings provide support for the role of folate metabolism in the development of primary brain tumors. In particular, genotypes associated with increased 5,10-methylenetetrahydrofolate levels are associated with elevated risk. (Cancer Epidemiol Biomarkers Prev 2008; 17(5):1195–202)[1]

Down’s Syndrome is also linked to MTHFR.

Those with Down Syndrome have higher levels of Hydrogen Sulfide. This is because homocysteine is broken down into cysteine which is then transformed into hydrogen sulfide at some point. That said, taking vitamin B6 if having Down Syndrome may exacerbate the condition while taking TMG or L-5-MTHF may help alleviate it.

If one with Down’s Syndrome has MTHFR and is low in TMG or 5-MTHF, then homocysteine breaks down into cysteine which then breaks down into hydrogen sulfide.

Folate = folic acid.

In order to bypass the MTHFR mutation, one must take methylated folate which is often labeled as L-5-MTHF or 5-MTHF. Taking folic acid, folate, folinic acid or NatureFolate are inadequate.

Mother’s with MTHFR and MTRR mutations are at a higher risk of developing a child with Down’s Syndrome. [2]

I do not know anyone in Florida who works with MTHFR currently.

I am amazed at the lack of doctors who are knowledgeable about it and who take it seriously.

I am available for consultations if you would like to discuss MTHFR and other health concerns with me.

I also offer the ability for MTHFR testing if needed.

In health,

Dr Ben

1) Functional Polymorphisms in Folate Metabolism Genes Influence the Risk of Meningioma and Glioma
2) MTRR and MTHFR polymorphism: link to Down syndrome?


12 Responses to “MTHFR and Meningioma – Question”

  1. Jen July 3, 2014 at 2:45 am #

    I do not understand this. Does this mean if one has higher folate than one is more at risk for primary brain tumors? I thought the idea was to supplement to bring the folate level up? So does this mean that would make one more susectable?

    • Shelly October 29, 2014 at 5:52 pm #

      I had the same question myself Jen after reading the last line in the study results:” In particular, genotypes associated with increased 5,10-methylenetetrahydrofolate levels are associated with elevated risk. ” I checked the original study and it is not a typo.

      I would be curious to hear Dr. Lynch’s explanation.

      • Dr Lynch October 30, 2014 at 6:56 pm #

        Shelly – sorry – don’t see the question specifically – what is it you want to know?

  2. Rose August 17, 2015 at 5:23 pm #

    I was just diagnosed today with this gene. I was told I have (2) copies of the C677t and I don’t know what this all means. I am adopted and know that my biological mother died at age 22 of a heart attack (and she had 4 kids already), and my biological father died at age 42 of emphysema. I have a heart murmur that appears when I am sick. I have had EKG’s and they look ok as well as echo cardiograms. I have an irregular Q wave? Have always had it. I have recently been diagnosed by this same doctor as having rheumatoid arthritis. I was told before it was fibromyalgia which I wasn’t accepting as the fatique and brain fog were getting so severe. It all started about 5-6 years ago. I am now almost 54 years old and have of course outlived my Mom but am worried with this new diagnosis that I may have a short lifespan ahead too? My doctor says I will need to be on MHB for the rest of my life which contains B-12, B-6 and foliate? I had 3 miscarriages also in my thirties but had one healthy child at age 25 and one at age 39- a whoops! LOL Lately though I felt like my body was coming apart slowly, constant burning in my muscles and aches and the fatique was getting so severe I could hardly work. So I sought a more holistic approach and hoping it will work. I just don’t know what this all really means yet-still trying to research my diagnosis but thought I would post this for your research.

    • Dr. Aron August 30, 2015 at 5:41 am #

      Rose – welcome to the community! This page is a good place to start learning more.

  3. Wanda September 16, 2015 at 5:47 pm #

    I had a gene SNP done several years ago. I have not had a dr yet explain it to me.
    This is what Folic Acid or DNA Repair says:
    MTHFR 677 C>T
    MTHFR 1298 A>C
    I do understand I have a problem. But what does those numbers mean?
    I have had Meningioma tumors (Feb 2014) 1 lodged in my frontal lobe and 1 in my Occular Nerve behind my left eye. I had all but a small piece of the tumor removed from right behind my left eye. Had Proton Therapy to strink that (July 2014). Then I had an eye procedure on the left eye (Oct 2014). I have a cavernous angioma as well. All this is on my left side of my brain. Long story short, after eye procedure I was in the hospital for a week from extreme pain. Five days I dont even remember. But I do know that I did walk out of the hosptial . My whole right sie of my body had been affected by weakness and my gait was off. I was placed in Rehab were that was a nightmare–suffering seizure like activity, unable to walk with assistance more than maybe 10 feet before my head and truck area of my body swung backwards turning into seisure tremors etc. My ability to process info correctly ect has been affected. The trauma continues. Long story.
    Could this MTHFR problem have its ugly hand in all this? I am still having issues and now someone thinks I may have Conversion Disorder.
    I just need some help and answers. I keep being told that I am an interesting case.

  4. David December 4, 2015 at 6:48 am #

    It is a good luck that I’ve found your website. I am now anxiously writing this with a sincere hope to get to know the natural way to cure vestibular schwannoma or so called acoustic neuroma. As VS is quite similar to benign meningioma, I guess the same can be applied to VS. My wife has a big 4.3 x 3.2 cm VS in her brain. While she is opposing to do gene testing, I guess she may have MTHFR mutation(s)? By the way, our family, including our children and parents of my wife, do not have any brain tumor.

    As I could not understand, I’ve bought from Optimal Electrolyte, Adeno B12, HomocysteX, Optimal Iodine, Optimal Start, Active B12 Lozenge With L-5-MTHF, Liver Nutrients and Hydroxo B12. As my wife has a rather weak stomach with some symptoms of gastroesophageal reflux, she has been trying the nutrients one by one. Especially she has a serious allergic side effect, including stomach upset, on glutathion and NAC, which are very important for immune boosting, and a mild stomach problem on vitamin C and B12. Up until now, Optimal Electrolyte, Iodine, multivitamin are alright. She has no problem with milk. You said that in order to bypass the MTHFR mutation, one must take methylated folate which is often labeled as L-5-MTHF or 5-MTHF. Would you please guide us what kind of 5-MTHF and glutathion, should be taken for my wife to cure the VS?

    For your reference, below are the symptoms of my wife’s VS:
    On July 7, 2015, my wife found a 4.5 x 3.2 cm big VS, which was first found by very severe and acute headache on that day. If the VS grows 1.0~2.0 mm per year, it should have been growing for 15-20 years, unnoticed. I am totally sorry and responsible for my wife’s tumor, as we have been married for 21 years now. Thankfully with God’s help, her headache has substantially slowed down now.

    In spite of a very big tumor, she has quite normal senses, including hearing, vision, smelling and balancing, which are actually far much better than mine. Thus, she has now almost no severe symptoms of VS such as weakening of hearing, facial paralysis, tinnitus or poor balance, except occasional mild headache and slightly blurry eyes.

    My wife took her second brain MRI on Oct. 26, 2015. Thank God, her VS has shrunk a couple of mm to 4.3 x 3.2 cm. In spite of the giant tumor size, her doctor has recommended “wait and see” for six months as the tumor has shown a slight shrinkage especially in tumor cyst area, causing headache. We are very happy and excited about the progress for the past 110 days since the finding of the VS on the first MRI of July 7. My wife has been doing low carb/no sugar/alkaline diet with a lot of immune boosting natural nutrients since July, including curcumin, berberine, boswellia, vitamin D3/E/K, ubiquinon, omega 3, selenium, melatonin, CAPE, EGCG, resveratrol, quercetin, ginseng, etc.

    According to some medical paper, about 10% of VS patients have shown spontaneous shrinkage of the tumor. I guess they must have been doing some natural therapies to achieve the VS shrinkage, including acupuncture, herbal treatment, special diet, and anti-angiogenesis or tumor apoptosis inducing nutrients. And some of them are said to have shown total shrinkage of tumor.

    We will be waiting for your reply soon.
    Thank you very much for your warm and kind help.

  5. Alice February 12, 2016 at 9:09 pm #

    Hello my name is Dennis and my wife of 34 years have been diagnosed with 677-c and 1298-a. she is 69 years old and has multiple DVTS . She sees a Hematologist which He put her on Warfin 7.5MG a day and want Her INR to be 2.5 to 3.5, this has been going on for 2 years. With our INR machine through medicare and for anyone that wants to know we received the testing machine, strips, and lances.Allthough I check her blood once every 2 weeks and report the number to Alere where I got this equipment from with a Doctor Prescription, Then Alere reports it to our Doctor.Mind you that Medicare covers 80% but we have a supplemental which pays the other 20%, it is very expensive but this machine helps us making trips to our Doctor or Lab every 2 weeks.My wife also has a dorment Lupus Gene.I am not advertising about this. MY question is We do not receive any other medications to help with this BIG problem Can you advise me what I should ask my Doctor what else can we do to combat this problem, Please Help.

  6. Alice February 12, 2016 at 9:40 pm #

    DR Lynch this is Dennis again about my wife of 69 years old. although We use the machine I am a skeptic man so when I check my wife’s blood on this machine we have also done blood draws from their lab, as soon as we test her blood at home we go directly to the Lab and have her blood draw, than I compare both numbers, mind you She does not eat or drink anything between both tests. For the most part the numbers are the same except the first time they were way off due to a bad batch of Alere strips and we still go and have a blood draw once every 2 months.I am confessed reading about what she can do so maybee I need to have him explain about folic acid and vitamins that she should be on, I don’t know and I am not sure that He does not know, BUT he was the Doctor that required the test and specifically the 677 and 1298. I have heard that there are a lot of Doctors that do not know about these genesI like the Doctor but my wifes health comes first and by you suggestions I can ask Him. Thank you and PLEASE REPLY
    Dennis PS if anyone is on war fin or coumadin and want this machine the phone # is 1-855-209-8400 I just want to share what I know and this machine really helps

Leave a Reply

Read previous post:
Miscarriages and MTHFR Mutations – Question to Dr Ben

QUESTION: Hi Dr., I'm a little confused as far as what your recommedations as far as supplements for Mthfr-hetero type. ...