MTHFR and Methylation Podcast – by ND Update

Matthew Strickland, a current medical student at Bastyr University, interviews me about the topic of MTHFR and Methylation.

He definitely asked some great unique questions.

Enjoy it.

We talk with Dr. Benjamin Lynch today about all things MTHFR.  Press play to learn more about:

  • Why MTHFR is a real clinical issue
  • The ethnicities most susceptable to these defects
  • How to spot possible methylation defects clinically
  • The upside and downside of genetic tests
  • Why supplementing with methylated folate isn’t always a good thing
  • The idea and importance of dynamic supplementation
  • and more…..

See more at:

Full podcast and article is here: Dr Benjamin Lynch talks MTHFR and Methylation

7 Responses to “MTHFR and Methylation Podcast – by ND Update”

  1. Samantha June 4, 2014 at 10:16 am #

    Dr Lynch. I am so confused. I live in Australia and on AM/PM compounded supplements to address undermethylation. I have single copies of both C6777T and A1298C. There is a large amount of methionine in both. I have listened and read alot from you and others in the USA and you do not mention as such. I have been taking for a while as I was provided justification from Dr William Walsh. I thought it made sense. Should I be questioning this approach? Many Thanks

    • Dr Lynch June 4, 2014 at 5:40 pm #

      Hi Samantha – some of Dr Walsh’s work I agree with and some I don’t.

      Methionine can be helpful – but if you don’t notice any improvements, then you may need to take SAMe directly. Making SAMe requires more than just methionine – it also requires magnesium, ATP, low oxidative stress, low pathogen load.

      Evaluating your methylation with labs is the best way to go. SAM, SAH, adenosine, folates, homocysteine, lactate, nitric acid, etc

  2. Kay June 8, 2014 at 12:10 am #

    Loved this interview, have to be honest, some of this is over my head. But I so appreciate being able to listen and ponder.

  3. Nicole June 18, 2014 at 10:22 pm #

    Thanks for the podcast. I found out today that I have the C677T (T/T) and was researching to try and understand what it means. I’m fascinated to see a correlation with depression as I have struggled since middle school and I’m now in my 20’s. I also started having seizures in middle school that I understand to be psychogenic non-epileptic seizures. Have you found any correlations with PNES and the abnormal gene?

  4. Barbara July 3, 2014 at 2:19 am #

    Dr. Lynch,
    I am a 47 year old steroid dependent female. I found out yesterday that I am compound heterozygous for the mutations A1298C and C677T. I have asthma with bronchiectasis, migraines, fibromyalgia, osteopenia, borderline hypertension, obesity and carry an epi-pen due to anaphylaxis from sulfites. I currently take Prednisone 20mg, singulair 10mg, maxzide 37.5-25mg, xopenox inhaler, atrovent inhaler and use xoponex and atrovent in a nebulizer for breathing treatments, Vit D3 5,000iu, Vit C 1000mg, Ultimate Omega fish oil, Cardio ND, and started 1 pump of Advanced Methylation Formula Neuro-Immune Support yesterday. I should start niacinamide in the next week or two. I ordered the 23andme saliva test mentioned in this podcast. Should I also do the Methylation test from hdri labs and/or a mineral hair analysis from Analytical research Labs? I already do 15 of the 17 things you list to do. I don’t have a sauna or an organic mattress but am fragrance free, organic and non-gmo, I’ve done coffee enemas following the Gerson protocol, use acupuncture and chiropractic. I have no idea which other supplements to take or what to do from here. I enjoy your podcasts and am learning a lot. What do I do next? Where do I go from here?
    Thank you in advance for any recommendations,

  5. Jill August 31, 2014 at 7:23 pm #

    Dr. Lynch: I am MTHFR 1298 positive and I had been taking homocysteine prescribed by Tara Hickman for about one year until I started to get hives. I went off the supplement for 3 months and have been having to take a antihistime regularly to address the hives that come and go. Dr. Hickman suggested that I try Active B Trio instead because she thought the tmg in the homocysteine might be making me break out in hives. This past week I wasn’t feeling itchy so I took one Active B Trio and began feeling itchy again due to hive breakouts. Could it be the folate in the active B Trio supplement that is making me itch? What should I do?

  6. Judy Fanelli March 8, 2015 at 2:23 am #

    My son is has severe OCD diagnosis as well as a lifetime of ADHD, ASD and anxiety. He is now 22. His tests indicate pyroluria as well as being an undermethylator. He was on night and day supplements for both including methionine. We saw some improvement over the 12 weeks and then we added SAMe and inositol. He began pacing and highly agitated. He became a mess very quickly! Once we took him off all supplements, he returned to “normal” Can SAMe cause this in someone who is undermethylated?

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