Do you wonder if MTHFR is related to a specific cancer?
In order to determine if MTHFR and a specific cancer is related, one may search the medical research database, Pubmed.
Here are some results from searching the Pubmed Database on various keywords:
- MTHFR Cancer = provides over 2,300 articles as of March 12, 2012
- MTHFR oncology = provides same result
- MTHFR carcinoma = provides same result
- “MTHFR Cancer” = provides 0 results because “MTHFR Cancer” is not a specific cancer.
Evaluating the research done MTHFR may not be the best option for a few reasons:
- There are not enough studies done on various types of cancer and MTHFR defects
- Research is conflicting. One study says, “Yes, MTHFR is a risk factor” and another says, “No relation.”
- Time consuming. Digging through 1000’s of studies trying to find the specific cancer and MTHFR may not exist.
Other option is to understand what affect the MTHFR defects have on human function:
MTHFR Defects Lead to HYPOMETHYLATION if untreated
Hypomethylation = decreased methylation
There are many cancers that relate to hypomethylation. The research on hypomethylation is plentiful.
- Methylation Cancer = provides over 18,700 articles as of March 12, 2012
- Hypomethylation Cancer = provides over 1,300 articles
- Undermethylation Cancer = provides 40 articles
When determining if ‘MTHFR and ‘XYZ’ cancer are linked, using both searching methods is recommended.
“Is there a link between Chondrosarcoma and MTHFR?”
Here is an example of how to search PubMed to see if MTHFR is related to a specific cancer:
- Chondrosarcoma MTHFR = 1 result which demonstrates no link in Turkish individuals. Small study of n=56. Not significant enough.
- Chondrosarcoma Hypomethylation = 1 result which used a drug to induce hypomethylation in rats. Results demonstrate a link between hypomethylation and chondrosarcoma.
- Chondrosarcoma Undermethylation = no results
- Chondrosarcoma Hypermethylation = 3 articles which vary in their target genes. Methylation, either hyper or hypomethylation, are linked in cancer and it depends on which gene is affected.
MTHFR is linked to numerous cancers if methylation is not restored and balanced. Excessive methylation is as harmful as undermethylation. Health requires balance. Balance Methylation.
You are now immediately asking:
How to balance methylation?
Through an understanding of various markers on testing. Currently, this is being evaluated. There are a few laboratories measuring levels of methylation; however, the results are not providing useful information.
Out of all methylation tests I have evaluated, each individual has ‘normal’ methylation. I find this impossible especially since these individuals have MTHFR defects.
Rudimentary Methods to Understand if You’re Hypomethylated or Hypermethylated
- Measure blood levels of Histamine. Histamine requires methylation to be processed and broken down. If histamine levels are elevated, you are likely a hypomethylator. If histamine levels are normal, you are a ‘normal’ methylator. If histamine levels are too low, you are a hypermethylator.
- Take some Niacin in the form of nicotinic acid. Chew 1/10th a tablet of Niacin and then swallow. Niacin utilizes s-adenosylmethionine (SAM) when breaking down. If you flush strongly on 50 mg, you are likely hypomethylated (lack of SAM). If you do not flush much, you are likely a ‘normal methylator’ (balanced SAM). If you do not flush at all, you may be hypermethylated (excessive SAM).
- Side Effects from Methylfolate: If you are taking methylfolate and experiencing these side effects, then you are likely hypermethylated.
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