MTHFR, Depression, Pulmonary Embolisms: A Consult with Dr Ben

Listen to the 30 minute phone consult which Dr Ben Lynch held with a women diagnosed with an unspecified MTHFR gene mutation.

MTHFR (methyl tetra hydro folate reductase) is needed to tranform standard inactive Folic Acid into methylated active 5-MTHF.

Those with certain MTHFR gene mutations (I am of the belief that everyone should) must take only active forms of folic acid as 5-MTHF. If they do not, their homocysteine increases dangerously leading to pulmonary embolisms, deep depression, anxiety, atherosclerosis and cancer to name a few.

Dr Ben goes into some detail about MTHFR and how to reduce homocysteine by taking HomocysteX by Seeking Health.

HomocysteX by Seeking Health uses 5-MTHF, methylcobalamin (active B12) and pyridoxine-5-phosphate (active B6) and soon, TMG (trimethyl glycine). These four nutrients are crucial in reducing homocysteine levels.

Consider taking 2 capsules of HomocysteX in the AM with food and also 2 capsules at lunch time with food.

Always have your doctor monitor Homocysteine levels. This is a marker to see how well you are managing your MTHFR gene mutation.

Questions, comments are highly encouraged. Please comment below. Dr Ben will respond.

Medical Associations: FIND A GREAT DOCTOR (not a close-minded one)

  1. American Association of Naturopathic Physicians
  2. Orthomolecular Medicine
  3. Functional Medicine
  4. American Holistic Medical Association
  5. American College for the Advancement of Medicine
  6. American Academy of Environmental Medicine

Supplements recommended in this MTHFR Consult:

  1. HomocysteX: to reduce levels of homocysteine and bypass the genetic deficiency of MTHFR with active 5-MTHF. Consider taking 2 capsules in the AM with breakfast and 2 capsules at lunch.
  2. Magnesium Plus: to support healthy neurotransmitter production due to symptoms of depression. HomocysteX should help with depression immensely but likely won’t be enough on its own. Take 2 capsules with breakfast and 2 capsules before bed.
  3. Optimal Multivitamin: provides all necessary active B vitamins, active minerals and antioxidants. All are needed for most individuals yet most important in those experiencing any form of mental imbalance or highly oxidative condition like MTHFR. Consider taking 2 capsules in the AM with breakfast, 2 at lunch and 2 more at around 3 PM to maintain energy levels throughout the day.
  4. ProBiota 12 Powder: due to routine antibiotic use and symptoms of depression. Consider taking 1/4 teaspoon after dinner for 2 weeks and then up to 1/2 teaspoon after that. Once the bottle is finished, reduce to taking 1/8 teaspoon each evening after dinner or switch to taking 1 capsule of ProBiota 12 capsules.
  5. Optimal Iron Plus Cofactors: To replenish Iron stores due to iron deficiency. Take 1 capsule daily between meals. Before bed is ideal.
  6. Body Balance Oil: To balance inflammation with a healthy balanced oil. Take 1-2 tablespoons with a meal anytime of day. If digestive disturbance from it, take 1 tablespoon at breakfast and one at dinner to split up the dose.

Lifestyle changes recommended in this MTHFR consult:

  1. Mix 1 tablespoon of Apple Cider Vinegar with 1 tablespoon of lemon juice mixed with 1/2 cup of filtered water. Sip slowly first thing in the morning.
  2. Ensure eating some form of meal with protein every couple hours to maintain blood sugar and energy. Great for neurotransmitter development also.
  3. Coconut Butter for cooking and eating for general well-being.


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13 Responses to “MTHFR, Depression, Pulmonary Embolisms: A Consult with Dr Ben”

  1. Lisa February 12, 2014 at 2:25 am #

    Dr. Lynch,
    I have suffered Major Depressive Disorder and anxiety since I was a teenager. I am also a thyroid cancer survivor. Recently I tested positive for deficiencies of A1298C and C677T. Instead of a methylcobalamin tablet, my psychiatrist has me injecting 50ml shots three times a week and also taking NAC and TMG capsules with a multivitamin, chelated magnesium and fish oil. Are the shots more effective?
    thank you,

  2. Dawn March 15, 2014 at 11:54 am #

    Dr. Lynch; I’ve recently heard about treating depression with high-dose niacin. However, as a follower of yours, I’m under the impression that niacin wipes out the effects of methylfolate. (I’m homozygous C677T; lifelong severe depression/anxiety; hypertension, born with facial cleft defect). I would really like to hear what you have to say about niacin therapy, since I somehow have the impression that you have knowledge about treating bipolar. (BTW, I’ve been on your protocol for six months and have seen a marked improvement in my psych symptoms. In fact, I have been able to halve my Effexor dose WITHOUT the withdrawal brain-zap symptoms).

    (I’m really hoping you see this…I have two wonderful little boys and am missing out on their childhoods because of my psych problems. I’m getting desperate.)

  3. Kymari June 28, 2014 at 1:21 am #

    Hello Dr. Lynch,

    I was recently diagnosed with MTHFR in January, 2014. I am homozygous for the 1298 allele. Up until the last 10 years I have been in very good health except for mild depression and issues with constipation. Constipation is the only thing I’ve dealt with since childhood. I am currently 48 and have had 3 children with 3 pregnancies. No miscarriages. My body temperature typically runs low at 97.8 and generally have had low blood pressure, 105/65. I had a cardio scan done in December 2013 and it revealed I have zero plaque. Over the past 10 years I have been under considerably more stress than the average person, for various reasons. Anyhow, my weight has become a very big problem. I have always been in shape and worked out regularly but more and more am really struggling to lose weight let alone maintain. I have gained 30 lbs. in ten years and CANNOT lose it! I eat right and even record it, not to mention keep track of how many calories I burn daily through exercise. The last time I was at the doctor my blood pressure was up, 128/86, and it appeared as if I’m pre diabetic. What is up?! I don’t get it. This is driving me crazy! Is there any link between MTHFR and issues with weight gain and an inability to lose it? I would love to know what you do about this subject and if there is a correlation. And, by the way, I am not menopausal : ) I have also been trying to reduce the amount of stress in my life through yoga and church, however, it does not appear to have changed anything yet. All the doctors I’ve talked to tell me I’m either cheating on my diet and not being honest about what I eat and how much, its just part of growing old, I am not eating enough, I am eating too much, its all in my head or I’m peri menopausal and I just need to accept it. I’m not buying it. I know there is more to this story and my gut tells me it is related to MTHFR. My health is now at risk and it feels like nothing I’ve done has helped. I started taking Deplin daily in January and have seen some improvement with my memory but not with my weight. I really need to lose this weight so the rest of my body can function properly.

    Please respond! Thank you.

  4. Ana August 8, 2014 at 5:43 am #

    I have MTHFR 677C->T polymorphism ..heterozygous, Wild type G1691A, and C(APC) resistance, this test was performed on 12/1/2010 ….I had previous DVT, venogram showed 6 clots, groin to ankle, with permanent valve damage, at age 21 (1987, first pregnancy). Then another clot in 2009 from first airplane flight. treatments were heparin, Coumadin, and Lovenox. I had 3 children total, all born 2 weeks early, first one had VSD.
    Over the years..(I am now 47), I’ve suffered so many things I’ve never heard of before…. plus, chronic infections, malaise, fatigue, allergies, migraines with lights, vertigo, etc., had surgeries and misc. just plain sick! … I’ve recently been feeling nauseated, and have even worse fatigue than ever! ( muscle shakiness) …. I’m not sure ‘Where’ to start!? and what to take? …do you need to have prescriptions for these supplements?…….. Please help!? ANY suggestions would be wonderful!! Thanks in Advance 🙂 Ana

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