Those with MTHFR mutations tend to have elevated homocysteine levels or elevated s-adenosylhomocysteine.
Those with MTHFR mutations tend to be more toxic than those without because of an inability to detox properly.
I will discuss this in detail another time; however, I will touch on it as many antacids do affect the cytochrome P450 pathway. The cytochrome P450 pathway is critical in processing medications and toxins.
These are very serious issues and the last thing those with MTHFR mutations need is further aggravation of either one.
Well . . antacids aggravate those with MTHFR mutations.
Why do antacids make those with MTHFR mutations worse!?
- Antacids, specifically proton pump inhibitors (PPI’s) literally inhibit absorption of vitamin B12
- Some antacids literally shut down the body’s main detoxification pathway: cytochrome p450.
Research supports me:
B12 status declines during prolonged PPI use in older adults, but not with prolonged H2 blocker use; supplementation with RDA amounts of B12 do not prevent this decline. This report reinforces that B12 deficiency is common in the elderly and suggests that it appears prudent to monitor periodically B12 status while on prolonged PPI use, to enable correction before complications ensue.
Supplementation with B12 does NOT prevent this decline. Ouch.
What happens if someone has low vitamin B12? A few examples:
- Increased levels of homocysteine
- Sore tongue
- Inability to concentrate
- Increased risk of cancer
Don’t address the symptoms of antacids. Address the cause. Unless you want to have any of the symptoms or issues above.
Which antacids are proton pump inhibitors?
- Omeprazole (Losec, Prilosec, Zegerid, Ocid, Lomac, Omepral, Omez)
- Lansoprazole (Prevacid, Zoton, Monolitum, Inhibitol, Levant, Lupizole)
- Dexlansoprazole (Kapidex, Dexilant)
- Esomeprazole (Nexium, Esotrex)
- Pantoprazole (Protonix, Somac, Pantoloc, Zurcal, Zentro, Pan, Controloc)
- Rabeprazole (Zehcin, Rabecid, AcipHex, Pariet, Rabeloc, Dorafem)
Which antacids are H2 blockers?
- Cimetidine (Tagamet)
- Famotidine (Pepcid)
- Nizatidine (Axid)
- Ranitidine (Zantac)
I promised I’d talk about the other risk of antacids and their relation to increasing toxicity in the body.
If you plug the toilet and flush repeatedly, you get one heck of a mess.
If you take antacids which block the cytochrome P450 pathway, you get one heck of a mess in those with MTHFR mutations.
Cytochrome P450 processes toxins, chemicals and many many medications. If you prevent this from working, toxins, chemicals and medications do not get processed and they stick around longer in the body. As they accumulate, symptoms of pain, headaches, muscle aches, frequent fatigue, sensitivity to chemicals begins.
Which antacids reduce cytochrome P450 function?
- Proton pump inhibitors – so the same list as above
- Lansoprazole and Pantoprazole are the most potent inhibitors of Cytochrome P450.
- Rabeprazole has a thioester analog which is a very potent inhibitor of Cytochrome P450
Now if you have a reduced Cytochrome P450 for any reason, you want to try and remedy the situation as it is essentially one of your main detoxification pathways.
Talk with your doctor about getting off of proton pump inhibitors and switch to H2 blockers.
For a permanent solution and getting off of antacids, schedule a consult with me.
I’ve had great success repeatedly in helping people get off antacids for good.
Hello Dr. Ben,
I wanted you to know that I am off of Nexium and Prilosec!! I have been off of Nexium for almost 2 months and stopped taking the Prilosec over 2 weeks ago. Hooray! Thanks so much for your support.
 Journal of the American Medical Directions Association, Do Acid-Lowering Agents Affect Vitamin B12 Status in Older Adults?
 Proton Pump Inhibitors – Wikipedia
 H2 Blockers – WebMD
 Li et al, COMPARISON OF INHIBITORY EFFECTS OF THE PROTON PUMP-INHIBITING DRUGS OMEPRAZOLE, ESOMEPRAZOLE, LANSOPRAZOLE, PANTOPRAZOLE, AND RABEPRAZOLE ON HUMAN CYTOCHROME P450 ACTIVITIES, Drug Metabolism and Disposition
 Cytochrome P450 – Wikipedia