MTHFR Questions? Methylation Questions? Ask

In order for me to help you more effectively, I want to know exactly what your questions are.

Questions will not be answered here. They will be answered via these avenues:

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Please post ALL your questions about MTHFR and methylation below using the Comment feature.


Guide to Making a Useful Question:

  1. Keep the question general.
  2. No personal questions.

Example good questions:

  • What does MTHFR stand for?
  • What is methylation?
  • How come folic acid is not recommended for those with MTHFR?
  • Which form of vitamin B12 is best? Why?
  • How much methylfolate should be taken by a pregnant woman?
  • Why does methylfolate make some people anxious in small amounts?
  • Why do doctors use folic acid?
  • What drugs are bad for MTHFR?
  • Which anesthesia is recommended for those with MTHFR?
  • Why do you recommend vitamin B12 with methylfolate?

Example bad questions:

  •  I took methylfolate last night. It made me itch. Why?
  • My doctor gave me Deplin and I felt great for 3 weeks and then terrible. Why?
  • Should I test my daughter for MTHFR?
  • Anything with ‘I’ or ‘me’ in it

Thank you for supplying all your questions below and I appreciate you following the useful question format!

Ask your question now.

Can’t think of one now? Like this page or bookmark it and come back anytime.

54 Responses to “MTHFR Questions? Methylation Questions? Ask”

  1. J February 18, 2014 at 9:49 pm #

    Is it safe to begin taking folate in vitamins (have MTHFR mutation) while nursing?
    Would a detoxifying affect be safe?

  2. Jackie March 16, 2014 at 5:24 pm #


    My grandmother and mother died at ages 39 and 54, possibly due to MTHFR. My Uncle was diagnosed with it after he passed a complete physical, then shortly after had a major heart attack. He took his folate as directed and died at 57.
    Interestingly, my Uncle, mother and grandFAther all had brain tumors. I’m not sure if there are any correlations between MTHFR and tumors. (Especially when the MTHFR probably came from the Ashkenazi side, not Grandfather’s. They seem to have more health issues and die younger.)
    One cousin is homozygous, while I have C677T only. Nobody else will get tested, they believe if there are no symptoms, there is no problem.
    I’m fairly in agreement “if it ain’t broke, don’t fix it.” We may not have the same fate as our parents.
    However, we seem to be predisposed for specific health issues and premature death.
    The debate we’re having is: why would one get tested or take medicine if it doesn’t appear needed?
    Doctor says 50% of the population has the MTHFR mutation and 30% of them don’t need to treat it.
    So, are we treating symptoms or mutations?
    I would think you treat the cause to eliminate the effect.

  3. Cherry April 20, 2014 at 9:03 pm #

    Is Leucovorin Calcium ever recommended for those with MTHFR defects and if so, why?

  4. Ashley Sutton June 6, 2014 at 2:04 pm #

    Is general anesthesia safe for ages two and under with homozygous C677t? Does it increase learning disability and autism risk? Is a local anesthesia a better choice?

    • Kate June 10, 2017 at 2:52 am #

      I make sure the anesthesiologist knows about my Homozygous MTHFR C677T mutation and they give me a straight Propofol NEVER a mixed anesthesia. I am fine, have had two surgeries since finding out. NO nitrous oxide ever! Whenever possible I have a local, as in dental work.

  5. kris June 7, 2014 at 6:41 pm #

    Which form of vitamin B12 is best? Why? Where can I go to get more information? (What are your sources? ) Thank you. k

  6. Melinda June 26, 2014 at 12:55 am #

    I am hetero for C677T and have a bad reaction to b vitamins and unable to take them. My doctor doesn’t know much about mthfr but prescribed natural food vitamins (either Standard Process or Garden of Life Kind Organics to get the folate and b vitamins I need. Am I correct in the fact that the C677T makes it important to get the folate to the brain and will this work as the methylated and regular do not? How much does one need? Thank you!

  7. Beryl Moors June 26, 2014 at 5:34 pm #

    I am trying to heal leaky gut. If I have MTHFR defect, can I still take the supplement L-Glutamine?

    • Kate June 10, 2017 at 2:54 am #

      I take L Glutamine and L-Lysine and I am Homozygous for MTHFR C677T. I found out I am deficient and it has helped me. I have had no ill effects.

  8. barbara smith June 28, 2014 at 7:46 am #

    No you cannot take L-Glutamine with a positive MTHFR. It is an excitotoxin and will not serve you well at all.

    • Dr Lynch June 30, 2014 at 6:33 pm #

      Barbara –

      That is not a true statement. People with MTHFR can take glutamine. Glutamine can convert to glutamate which is an excitatory neurotransmitter. It is not an excitotoxin. Glutamine is a very important nutrient for many people. In the gut, it gets used first. Taking the right dose is important. One can convert glutamate to GABA by using magnesium and B6.

  9. Melinda June 30, 2014 at 6:48 pm #

    Help please! I am pretty desperate here. I react badly to b vitamins methylated or regular. They make me feel irritable and crazy. I tried whole food vitamins and they aren’t any better. Can anyone tell me what to take? Single mthfr and my son who is double reacts terribly also.

  10. Barbara Smith RN CCM July 1, 2014 at 12:15 am #

    I guess it depends on who you ask. Dr. Nancy Mullan and Dr. Amy Yasko state that those with MTHFR cannot take L-glutamine because it’s an excitotoxin. Apparently there are differing opinions on this topic.

  11. Trisha Loomis August 15, 2014 at 3:46 pm #

    My friend has the mthfr mutation C677T and she has been told her not to eat foods high in Vitamin K like kale due to blood clots. Is this a correct? He also had her on high doses of folic acid. I told her to stop that and start taking folate.

  12. Mara September 12, 2014 at 7:17 pm #

    In one of your articles you mentioned to take Vitamin C at least 30 minutes away from Folate. What about extended release / time release Vitamin C (1000mg)? Would that hurt Folate more because it’s being absorbed throughout the day, or is it safer because it’s not a large amount at one time?

  13. Michelle September 30, 2014 at 9:48 pm #

    Hi Dr. Lynch,

    I just got my labs back for B12 and it was out of range on the high end. I am not taking that much. I am taking your B complex from seeking health. I think I read somewhere that it could be an absorption problem? I am homo for MTHFR and working so hard to where I can tolerate more folate. I suspect that I have some chronic infections but since I am so sensitive I am afraid to do any chelation. Which is probably something I should ask in a second email- sorry.

    Vitamin B12 range/ 211 – 911 pg/mL my result/ 1115

  14. Lynn October 21, 2014 at 4:55 pm #

    Overmethylation and undermethylation seem to have overlapping symptoms. How is it confirmed which is taking place?

  15. Gwen Schneider October 27, 2014 at 2:22 am #

    What do you think about the new transdermal methylation creams?

  16. Stephanie January 15, 2015 at 12:04 am #

    I keep reading that there are potential drug toxicities with the MTHFR. I see articles on antacids, methotrexate, nitrous oxide, and anti-epiletics. I know I have seen other information, especially with regards to antibiotics but not sure where. I had severe life altering reactions to Cipro. I am homozygous C667T.

    It seems like Macrobid shouldn’t be given to people with low vitamin B??? And that sulpha drugs won’t be processed well??? I believe I read anethesia might be harder for some. Is there a list of medications to avoid and suggested safer meds? This would be extremely helpful as I suffered from UTIs in the past and terrified of taking medications after my last incident. I would like this info for myself and also my cousin’s children suffering form the same thing.

    • Kate June 10, 2017 at 2:58 am #

      I have had a very bad reaction with hospitalization due to macrobid for a bladder infection. I am homozygous for MTHFR C677T also. I have taken cipro many times with no adverse effects but I am going to avoid that one. Thank you for sharing. Macrobid almost killed me! I was never so sick in my life.

  17. Viola Newman January 15, 2015 at 10:05 am #

    I’m interested in the answer to your question. My son is homozygous C667T also.

    He cannot take any kind of antibiotic at all without an allergic reaction. So far, my cure for this has been to keep him away from the doctor! When he is sick, I use herbs and foods for antiviral and antibacterial properties like. But it scares me if he should ever be hurt or have a really bad infection and in the hospital. He had many antibiotics as a young child and reacted badly to each one within a day or two of starting them.

    He is almost 12 and hasn’t had an antibiotic since he was 6.


  18. michelle March 14, 2015 at 2:20 pm #

    i have lyme disease and biploar. my physc doc just hapened to to this test call mthfr. what does this mean. he wants to put me on deplin. i wrote in my lyme group and some people told me not to take it. would the deplin help me? what kind of doc should i be working with for the mthfr gene?

  19. Diane April 15, 2015 at 4:16 pm #

    I need to know if Folinic acid is bad for me to take. I am taking Leucovorin Calcium 10mg. Is it helping me or hurting me? Is Folinic acid, another word for Folic acid? All I have read about my folate defiency is to not take folic acid. I am on a low income and I can’t afford expensive folate supplements. Which brand do you recommend that is affordable(no more than $15.00) and what is the recommended mg.or mcg. that I need. I was diagnosed more than a month ago and I am still not feeling better. Please help me as soon as possible. I need to be able to function again. Thank you very much!

    • Aron Choi April 16, 2015 at 11:54 pm #

      Diane, it depends why you were prescribed Leucovorin by your doctor. It’s often prescribed to address the side-effects of anti-folate antagonists, like methotrexate. If you are experiencing symptoms, you may want to discuss with your doctor.

      Folinic acid is NOT the same as folic acid. Folic acid is a man-made form of folate and not easily converted into the form your body needs. Folinic acid is a naturally occurring form of folate in food, especially leafy greens.

      Dr. Lynch has an extensive explanation here with some action steps at the end of the article:

  20. DD Davis April 28, 2015 at 8:47 pm #

    Are there any Multi Vitamins that are helpful for people with MTHFR Mutation?

  21. Samantha Gove June 17, 2015 at 2:08 pm #

    Which anesthesia is recommended for those with MTHFR? I have two 1298C mutations.

  22. barbara s mith June 17, 2015 at 9:40 pm #

    I have to have surgery and wonder what general anaesthesia is safest or acceptable for MTHFR positive people

    • Dr. Aron June 17, 2015 at 9:59 pm #

      Barbara – I can’t speak specifically to general anesthesia recommendations. However, there is a significant issue with nitrous oxide for general anesthesia and methylation dysfunction. You can read Dr. Ben’s recommendations on how to avoid using nitrous and what to do if you absolutely cannot avoid nitrous oxide.

  23. Ginger August 8, 2015 at 2:43 am #

    I also have a surgery coming up (general anesthesia), and will have to have another within a month of that one to remove a cancerous breast lump (beginning my journey). Aside from nitrous oxide, I’d really like to know what anesthesia meds are recommended and/or contraindicated. I have many polymorphisms. Compound hetero for the two mthfrs, homozygous for: mtrr, comt, maob, gstp1, nos2, sod, and so many more. Please advise. Surgery just 2 weeks away. I’m taking (2 months now) intramuscular folinic, hydroxylcobalamin, and glutathione; and I’m still not noticing any improvement. I started slowly, and have also tried greatly increasing doses, and still nothing. Health has declined to such an extent, I’m not sure if I expect to awaken from surgery, and I’m a 40 year old single mom of two teens!

    • Dr. Aron August 15, 2015 at 12:43 am #

      Hi Ginger – Declining health is definitely not an easy thing to deal with. Do you have a doctor you can trust to help you in this area? If not, please search the physician directory find a doctor who has completed training with Dr. Ben here. A great book on the subject of integrative approaches to cancer is “The Definitive Guide to Cancer.” This article on MTHFR and breast cancer might also give you some discussion points to discuss with your doctor. I hope this helps you start moving in the right direction. Please keep us updated on how you are doing.

  24. Rose September 3, 2015 at 6:31 am #

    Hi Dr L

    Are there any anesthesia drugs that shouldn’t be used in pediatric procedures, for children with mthfr mutations? If Carboncaine with epiephrine, Midazolam, and Sevoflurane were the planned drugs to be used in a 3 year child who is homozygous mthfr a1298c, are there better alternative drugs which could be used? I am aware that nitrous shouldn’t be used. Thank you!

  25. Terri Swearingen December 22, 2015 at 7:02 pm #

    Does L-glutamine interfere with the methylation cycle? What about NAC? What about sublingual liposomal glutathione?

  26. Julie February 21, 2016 at 5:29 am #

    Oftentimes, more holisticly minded doctors prescribe high dose niacin for cholesterol management. Is this harmful to people with mthfr variants or associated snps? Does it make any difference if it is a “non-flush” variety of niacin?

    • Dr Lynch March 8, 2016 at 6:59 am #

      Yes it can be harmful. Need to also support with nutrients which support methylation.

      I do prefer the flush form of niacin – as nicotinic acid – as the non-flush can be hard on the liver.

      Talk with a nutritionist or health professional trained in nutrition.

  27. Colleen March 15, 2016 at 8:36 pm #

    how much alpha lipoic acid should be used with a homozygous positive for COMT on the genetic testing?

    Dr Hart

  28. Angela April 28, 2016 at 5:44 am #

    Is IV SEDATION safe for a 2 year old that has compound heterozygous MTHFR gene mutation? What anesthesia is recommended?

  29. Jessye May 11, 2016 at 5:18 pm #

    Pregnant with MTHFR deficiency. Recommended by CNM/ARNP to take 4 mg/day of methylfolate. Heard many good things about active B-12 & L-5-mthf sublingual lozenges from Seeking Health. Could 4 lozenges/day result in too much B-12? In your opinion, is 4 mg of methylfolate/day ill advised?

  30. Cathy May 15, 2016 at 4:13 pm #

    My daughter is compound heterozybus for one copy of 677T and one copy of A1298C. She has been chronically ill for almost 7 years until we found out this was causing a lot of her problems. We are currently looking for a functional doctor in the Austin area. She is highly sensitive to gluten, soy among a lot of other foods. We’re having a hard time finding her vitamins that are totally free of soy. The vitamin E in certain brands makes her sick because of that. Any recommendations would be appreciated.

  31. Sarah Woodruff June 13, 2016 at 11:00 pm #

    My son (9 yrs old) will be undergoing anesthesia for 2 1/2 hours of testing. He has autism and a mutation with his MTHFR gene. I also know he is a poor methlyator. I’m worried about the amount of anesthesia his body will be receiving. Can you please advise on how to best prepare his body, and also guide the doctor who will be putting him under. Thanks so very much.

  32. DB June 20, 2016 at 3:25 pm #

    What kind of supplementation should a person with the following SNP mutations take?

    +/+ for VDR Bsm, MAO-A R297R, MTRR A55G, and BHMT-08.

    +/- for COMT V158M, COMT H62H, MTHFR A1298C, BHMT-02, AHCY-01, AHCY-19, CBS C699T, CBS A360A.

    All of the others are negative except for those with no call: MTRR H595Y and R415T, BHMT-04, AHCY-02, CBS N212N, and SHMT1 C1420T.

    Still not 100% on Methylfolate, B6, Curcumin / Black Pepper, B12, and occasional Niacin / Tylenol.

    Thank you so much. You are an invaluable resource.

  33. Michelle February 23, 2017 at 12:16 pm #

    I’m heterozygous for both alleles and have been following the protocol for about 9 months. I have a few questions:
    1. I’ve noticed profound “shedding”/hair loss daily – is there something else I should be taking to combat this?,
    2. My fatigue has not improved (and is severe)…I even went to an endocrinologist who took one look at me and said, “You don’t have a thyroid condition” (normal TSH)…anything else I can do?!?
    3. I cannot lose weight despite regular exercise and improving my diet…

    When I first discovered MTHFR, I thought I found the answer to so many questions/concerns that I had, but…I still just don’t feel “healthy” like I should.

  34. Mallory C March 3, 2017 at 2:21 am #

    I’m 31yr female homozygous c677t. Started taking Deplin 6 months ago. My right eyebrow hairs have drastically started turning white, nearly 1/3 covered. I suspect B-12 is involved but I’m having trouble understanding the processes. Anyone else have this problem?

  35. Carolyn March 27, 2017 at 5:46 am #

    Hi there,

    What (if any) is the relationship between MTHFR and eosinophilia?

    • Dr Lynch March 28, 2017 at 5:46 am #

      Possibly related as MTHFR can increase histamine levels due to decreased methylation.

  36. Amanda Hutchinson April 11, 2017 at 9:11 pm #

    Is it okay to take Biotin if you are homozygous C677T? I am on MetaNX

  37. Lee A April 17, 2017 at 5:35 pm #

    which anesthesia is safe for 6 month old needing ear tubes?

  38. Lizette May 14, 2017 at 3:43 pm #

    Is the mthfr mutation a possible cause of mullerian anomalies?

  39. Viola Newman May 30, 2017 at 11:52 am #

    I think this site sucks. There are many question being asked that I would like to know the answers to, but I have no idea where to find them. How is this useful to anyone besides yourself? Do I have to go search up and buy every book you have or webinars you do? We’re all helping you by giving you the questions we would like to see answered but you give us no way to find them.

    • Dr Lynch June 1, 2017 at 3:44 pm #

      I have a YouTube Channel, Facebook account and many articles here.

      I agree that the site needs to be more structured – and it will be.

      Many projects going on which make it difficult to get to – but we’re getting closer.

      I invite you to also check out which has some more current articles and videos.

  40. Beryl Moors May 30, 2017 at 5:05 pm #

    I totally agree. it’s really just a chat site where people who are looking for answers all muddle around together and never get any input from the experts.

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