MTHFR Questions? Methylation Questions? Ask

In order for me to help you more effectively, I want to know exactly what your questions are.

Questions will not be answered here. They will be answered via these avenues:

  • Webinars
  • Articles
  • Videos
  • Book


Please post ALL your questions about MTHFR and methylation below using the Comment feature.


Guide to Making a Useful Question:

  1. Keep the question general.
  2. No personal questions.

Example good questions:

  • What does MTHFR stand for?
  • What is methylation?
  • How come folic acid is not recommended for those with MTHFR?
  • Which form of vitamin B12 is best? Why?
  • How much methylfolate should be taken by a pregnant woman?
  • Why does methylfolate make some people anxious in small amounts?
  • Why do doctors use folic acid?
  • What drugs are bad for MTHFR?
  • Which anesthesia is recommended for those with MTHFR?
  • Why do you recommend vitamin B12 with methylfolate?

Example bad questions:

  •  I took methylfolate last night. It made me itch. Why?
  • My doctor gave me Deplin and I felt great for 3 weeks and then terrible. Why?
  • Should I test my daughter for MTHFR?
  • Anything with ‘I’ or ‘me’ in it

Thank you for supplying all your questions below and I appreciate you following the useful question format!

Ask your question now.

Can’t think of one now? Like this page or bookmark it and come back anytime.

136 Responses to “MTHFR Questions? Methylation Questions? Ask”

  1. Cynthia White September 21, 2012 at 1:04 am # Reply

    Where can I get BH4 in the Seattle to Bellingham area?

    Thank so much!

  2. Dolores September 21, 2012 at 3:41 am # Reply

    Can methylB12 have side effects like the methylfolate has side effects, especially if there is another mutation? Can methylB12 make a person feel good at first, then worse after taking it for a period of time?

  3. sapna September 21, 2012 at 8:38 am # Reply

    Is this a lifelong diagnosis
    Can the Methalation pathways be reversed through diet or supplements?

  4. Marian September 21, 2012 at 11:10 am # Reply

    Adenosylcobalamin has a very serious side effect for me: serious depression sinks in within a few hours after taking a 3000mcg tablet. I am normally not depressed and the depression lifts after two horrible weeks. Hydroxocobalamin (which changes into adenosylcobalamin and methylcobalamin) injections have a similar effect. Few people have this side effect, but I am not the only one.

    I now take methylcobalamin injections without any problems, but know that I also need adenosylcobalamin. I am compound heterozygous for mthfr c677t and a1298c and take methylfolate.
    I have read that methylcobalamin is also changed into adenolsycobalamin. Do you know whether this is true and if so would you know how much of the methyl is being changed into adenosyl?
    Would the MTHFR have anything to do with this problem?

  5. Alan September 21, 2012 at 5:12 pm # Reply

    How does a person with a homozygous MTHFR mutation know when they are taking enough methylfolate, B-12, etc?

    Is this a case of better to take a little too much rather than a little too little?

    Does the answer change with 677 vs 1298 mutations?

    If a person with homozygous MTHFR drinks alcohol on occasion, should they take additional supplements at that time?

    OK, four questions, but I tried to make them “good” ones. I haven’t seen these discussed on your site – although the site is large and I don’t claim to have read everything. Thanks in advance.

  6. Michelle September 21, 2012 at 5:42 pm # Reply

    Hi Dr. Ben,

    I am very grateful for the work you do. We scheduled an appt for our 3.5 year old son in Oct. He has a double copy MTHFR 677t. We cant seem to figure out all of his symptoms and we are so confused as he has near psychotic rage fits with methy b12 or l-5-MTHf even in the smallest dosages. I know he needs something, I can give a TINY bit of NAC and L-methionine and a TEENSY bit of methy b12 and calcium folate but he is still unbalanced. We are desperate to help him as he has suffered so much. We really want to optimize our appt with you. Given his reactions to methyl b 12 etc from reading your forum I am guessing he sadly also has another SNP issue. Do you recommend us testing that first and waiting for the results before our call together? If so, can you recommend where? Amy Yasko? Genova? What do you suggest.

    Thank you,


    • Viola January 17, 2013 at 12:54 pm # Reply

      Just want to caution you not to be so quick to decide he can’t handle the B12. For my son, we had to go with a cream that we apply to his skin because he is so sensitive to the preservatives and sweetners used in most B12 supplements.

      My son also has a double copy of the C677T and had suffered with chronic health problems since birth. He is ADHD and has these rages and very strong reactions to certain supplements and even certain foods. Check the other ingredients in your supplements.


  7. Jess September 21, 2012 at 9:24 pm # Reply

    During my last pregnancy,I was diagnosed with homozygous csomething MTHFR. I had Preeclampsia twice and one neural tube defected child. Also thryoid cancer. I was wondering if it is a ll connected with MTHFR. Also,is this type a blood clotting issue? My OBGYN said it was not. Also,how likely is it that my children inherited this from me? I can not find a doctor who knows anything about this issue.

  8. debbie September 22, 2012 at 7:26 pm # Reply

    Hi Dr Ben, I tried the wet foot technique 3 times. Top wool socks never got dry but the cotton ones on top did. Guess it was the socks. Anyway, I was wondering about my condition. CFS two years. The doctor tested for MTHFR 3 months ago. The results are hetero c677t andA1298C mutations. Dr perscribed cream of folate and methy B12, 6mg but he raised it last week to 50 ml ! I wonder about Hydrocortisone and 1.5 grains thyroid. Will the folate affect that. It feels that the cortisol is making me worse but don’t really know. Its only .5, 2 in am 1 lunch 1 dinner. Do you ever recommend cortisol? I’ve read that it will make your adrenals stop working. Have you seen CFS be caused mostly by MTHFR mutations. Been to many doctors still not improved. Thanks for any advise you may have.

  9. Shawn Bean September 22, 2012 at 8:53 pm # Reply

    Dr. Ben,
    I just received your methyl b-12/5- methylfolate sublingual. I can not be more pleased with service. When looking on the directions it says to take with food or swallow whole. If it is a sublingual form then wouldn’t taking it with food slow the absorption down resulting in not being totally absorbed in the system. In a compromised Gi tract, wouldn’t be taking it away from food and water allow it to be more absorbed buccal more readily in the blood stream.? Thank you for your devotion to further research into this crucial over looked area in medicine. Did you happen to get my response to your email the other day.

    • Dr Ben September 24, 2012 at 8:55 pm # Reply

      Shawn –

      Thank you for pointing this out – I will remedy this label so it has appropriate instructions!

      You definitely benefit better by placing the lozenge between your lip and teeth or under the tongue away from food.

      I am finding that some people need to take b12 and methylfolate after a meal or fairly soon after. This is most useful in individuals who tend towards the anxious spectrum. It is important that their blood sugar is stable prior to taking any b12 or methylfolate.

      Glad service was excellent for you.

  10. MaryS September 23, 2012 at 3:11 am # Reply

    One of the functions of methylation is to “turn genes on and off”. What does this mean exactly for someone with MTHFR mutations?

  11. Holly Glaser September 25, 2012 at 1:40 am # Reply


    After taking Deplin, my throat felt itchy bu I continued the Deplin because it helped me be less depressed. After a few more days I would up in the ER with anaphalaxis.

    Later I was given a shot of B12 vitimin – my level was low – and a second time I got anaphalxis and again went to the ER.

    I have been told that this is not related to my C667T homozygous MTHFR. Is this true?
    I think that given my bad reaction to Deplin, They should not have given me B12. –

    What is your opinion?

  12. Anna September 25, 2012 at 5:58 am # Reply

    I am confused as to what products to order. In one part of your site it says to start with a multivitamin including B12 and methylfolate (such as the optimal) . In other sections it says to start with vitamin B12 as methylcobalamin and then add methylfolate.

    I have compound heterzygous mutations C677T/A1298C, gluten free/dairy free for 5 years.

    I have spent a lot of time looking at your different supplements but not clear which path to take. Thank you.

  13. Carrie Ward September 27, 2012 at 2:21 pm # Reply

    Have you seen any correlation between Sensory Processing Disorder and MTHFR?
    Have you seen any correlation between heavy metal toxicity from Heart stents with those who have MTHFR?

  14. natalie September 28, 2012 at 4:32 am # Reply

    Are there any specific drugs that some with the mutation, shouldn’t take ? I am taking so many different drugs–for so long—and i need to change over to more of what you are taking about….so what about anti-spasmodics, anxiety meds, hydrocodone, Lyrica, depression meds……..are any of these REAL bad in combination with having the MTHFR-C677T….?

    • Keshia December 20, 2012 at 6:52 pm # Reply

      This is something I am curious about, too!!

  15. Maria Snodgrass September 28, 2012 at 1:14 pm # Reply

    Hello I was diagnosed with heterozygous, it came about because I was having severe Nerve pain. I had been taking Metanx for about 4 months and it did not help my nerve pain. Doctor says I need to stay on something since I have both of the mutations but my insurance is no longer paying for this medication.

    Can you tell me where I can get same level of medication over the counter. I was told I could get it on your web-site but can’t seem to find it.

    Thank you! Maria Snodgrass

  16. susan mcfarlane September 28, 2012 at 5:33 pm # Reply

    Dr. Lynch
    I have just spent 3 hours watching and reading many great things on our website.

    I have been diagnosed with both MTHFR genes.

    I presently take a multivitamin (Dr. Mercola)
    which has the folate and B12 you have talked about. Should I still take your sublingual one to make sure I receive enough B12 and folate?
    I will also give this to my husband as his homocysteine is a little high.
    One of my daughters (21) is negative and my 26 year old is about to be tested.
    Also should I not take any L-arginine (for the nitric oxide?
    I also take
    Dr. Mercolas probiotic (2 a day)
    Xtend Life fish oil with (Omega 3/GH Ultra)
    Dr. Mercolas Astaxanthin (325 mg ALA)
    Life Extention Super Bio-Curcumin
    MegaFood Blood Builder (my ironlevels are very low)

    I have cut out dairy and drink unsweetened almond milk.
    Eat organic 90%
    Drink filtered water
    exercise (run 2 miles every day)

    I do have other issues where I had a 6 hour urine test and found I had many heavy metals inside of me. I do not want to detox until the metals are out of my mouth (I have several crowns containing silver and gold) I also have 5 root canals (I thought I only had 2)

    I am delaying the dental work because of the cost around $25-30,000.

    I have suffered from swollen hands and feet for about 5 years and hot tingling sometimes red. The doctor thought RA or Raynauds (as my nails are ridged and sometimes dented a little) Since trying to help myself (I think definately cutting out dairy) I no longer have swoll

    My mother (76) has been suffering from mini strokes for the past 5-10 years and ultimately she has been diagnosed with vascular dementia and is rapidly going down hill. This is shocking as she has always been health concious taking supplements before it was ‘fashionable’. Exercising etc. Never had high blood pressure or cholestorel issues. She has always battled anemia.

    Do you think the vascular dementia could have been brought on because she was never diagnosed with MTHFR genes? Her father also suffered the same at around the same age. On his death certificate was Dementia/Thyroidisim?

    I am trying hard to take care of myself, husband and two girls. I find the conventional doctor useless and only want to give me pills.

    I apologise for such a long email but after three hours I’m motivated to make sure Im doing all that I can do to acheive good health.
    Kind Regards

  17. Stephanie Ward October 6, 2012 at 1:07 am # Reply

    I was recently diagnosed with MTHFR (homo). I am struggling finding foods to eat that are low in folic acid. My Doctor just prescribed me cerefolin. Does this mean I still need to eat low folic acid foods? Or with this help digest them? Do you have a list of health food that are low in folic acid? This list would be very helpful to me.


    Stephanie Ward

  18. Elisha October 11, 2012 at 12:27 am # Reply

    I would love to see full in-depth explanations of all your lifestyle recommendations on the C677T protocol article.

    Right now, I would be interested to know about side effects of coffee enemas – possible causes if one feels lousy many hours after (having felt fine earlier).

    Looking forward to a big, fat book with masses of information for me to work through :)

  19. Melissa October 11, 2012 at 4:27 am # Reply

    in the article about the basic protocol to follow for those with the MTHFR C677T mutations you say to:
    11.Eliminate Gluten from your diet – especially wheat.
    12.Eliminate or reduce Dairy from your diet. If you must have dairy, use Goat milk.

    What is the reason for this? Do those with a MTHFR gene mutation have trouble breaking down gluten and dairy similar to the trouble with folic acid? What if one has only 1 copy of the gene mutation? Is it then enough to just significantly reduce gluten and dairy, but still consume a little every once in a while, or is it detrimental to one’s heath no matter how much or little is consumed? If one is taking all the proper supplements as you suggest, then is there a little room for error on ingesting a small amount of gluten and dairy, meaning the body will be able to “handle it” if supplemented properly?

  20. Brian October 15, 2012 at 4:43 am # Reply

    Hi Dr. Ben –

    If dizziness/vertigo has persisted 6 weeks after stopping Deplin 15mg, will niacin or turmeric still be effective? Or is there a better solution?

    Thank you for all the helpful information!


  21. Alan October 16, 2012 at 10:32 pm # Reply

    A family member has just been diagnosed with MTHFR.

    They have homozygous C677T and heterozygous A1298C. I’ve seen discussion of homozygous at either site and heterozygous at both sites, but never this combination of 3 point mutations.

    Could the test be wrong? Is this an extremely serious case?

    I realize you no longer answer your web questions, perhaps some of your readers can point me at a resource.

    Thank you.,

  22. Pam Hopmann October 23, 2012 at 3:47 pm # Reply

    Hi Dr. Ben,
    I am compount heterozygous for the 1298 and C677 mutations, confirmed by lab tests. I have had horrible digestive problems for about 4 years, despite taking a very good probiotic daily during that time, and numerous alternative therapies. Recently I discovered that I am heavy metal toxic, mainly mercury and lead, and my doctor wants to begin a chelation process. However, I believe that my body is not currently not strong enough for that, and I would like to address my methylation problems first. Since you are no longer doing phone consults, do you have any suggestions for me as to how to proceed to get back on the road to health. Just to give you an idea of how serious my problems are, I can now only eat four kinds of foods: chicken, beef, butter, and almonds. Fruits and vegetables make me very sick. I have been gluten, dairy, soy free for the past three years, but my problems just seem to be getting worse. I appreciate any advice you can give me. thanks

    • Donni November 3, 2012 at 8:32 pm # Reply

      Based on experiences from similar symptoms, you may want to find practitioners skilled in NAET (allergy elimination technique) and Loomis Enzyme Therapy. These were the most significant factors in allowing my body to start assimilating nutrients from a variety of foods again without experiencing debilitating reactions. Hope this helps you as much as it did me.

    • Heather February 19, 2013 at 12:22 am # Reply

      Was an answer posted for this question? I’m compound heterozygous for one copy of 1298 and 677. Had post-partum pre eclampsia after birth of second child, no miscarriages, no blood clotting issues, heart disease on dads side of family, dad had massive heart attack at age 48 (still living, thank God), and I was diagnosed with Rocky Mountain Spotted Fever / Chronic Lyme disease 2 years ago.

      What are the step-by-step instructions on how to balance methylation for folks like me? A flow chart would great or listed steps that include “if this doesn’t work, do this”. All this information is overwhelming, especially folks that are very sick and afraid to take their health into their own hands, but have no choice, because docs don’t know that much (if anything) about MTHFR mutations!

  23. Sandra Dwan October 24, 2012 at 6:03 am # Reply

    Where and how does one get tested for the COMT, MAO A, and CBS gene mutations?

  24. Albert October 25, 2012 at 2:25 am # Reply

    Does the MTHFR mutation cause Lipoprotein (a) to be elevated? If yes, what supplements do you recommend for someone to lower Lipoprotein (a)?

  25. Joy October 30, 2012 at 7:08 pm # Reply

    When trying to get pregnant they recommend folic acid to prevent birth defects. If a person is positive for MTHFR what and how much should they be taking before and during pregnancy?

    What do you recommend to take/do for women with MTHFR & multiple early pregnancy loss besides baby asprin, 1mg of folic acid & prenatal?

    What can a person do in terms of prevention of MTHFR with your children, future children & grandchildren?

  26. Annemarie Palmer October 31, 2012 at 2:58 am # Reply

    Are there any good doctors in Michigan that treat MTHFR A1298C homozygous gene mutations that you know of?

  27. Brian November 1, 2012 at 4:03 am # Reply

    Hello Dr. Ben –

    Does the niacin in multivitamins negate the benefit of the methylfolate in them? For example: Optimal MVM (95mg niacin, 400mcg methylfolate) and Thorne BN III (160mg niacin and 500mcg methylfolate).

    Best regards,

    • Dr Ben November 5, 2012 at 7:26 pm # Reply

      Brian –

      The amount of niacin in a multi is typically fine. The Thorne BN III is getting a bit much though with 160 mg of niacin in my opinion. Under a 100 mg is ok for the standard person.

      We have to remember that methylation is a balance.

      Niacin is an excellent nutrient which is needed – and so is methylfolate. If we take too much of one and/or too little of another, then imbalance occurs. This balance shifts quickly so some days you may find the multivitamin is good for you and other days it is not.

      The multivitamin formulas I provide contain:
      – 20 mg of niacin and 400 mcg of methylfolate in the chewable multivitamin
      – 60 mg of niacin and 400 mcg of methylfolate in the kid’s multivitamin (which may also be used for adults – just need to take more capsules)
      – 95 mg of niacin and 400 mcg of methylfolate in the adult multivitamin

      • Brian November 7, 2012 at 5:48 am # Reply

        Thank you for the reply! The reason for my concern is that I took 50mg of niacin to see if it would help my vertigo (caused by Deplin 15mg 2mo ago) and I experienced extreme flushing on my entire body (it didn’t help the vertigo). I believe this means I’m hypomethylated. If so, should I switch to a multi with less niacin (I take the BN III) or try adding more methylfolate in a much smaller dose than Deplin?

  28. Dolores Seames November 3, 2012 at 11:47 pm # Reply

    Dr. Ben,
    Is meriva curcumin a methylator, or demethylator? It seems to help a bit with muscle pain that the methylb12, I think is causing. Any amount of methylfolate makes the pain worse, so is this overmethylation, or just detox?

  29. Alan November 5, 2012 at 8:31 pm # Reply

    I noticed that you have answered a few questions, I’ll re-submit this one, as I have been unable to find it mentioned anywhere.

    A family member has been diagnosed with MTHFR.

    They have homozygous C677T and heterozygous A1298C. I’ve seen discussion of homozygous at either site and heterozygous at both sites, but never this combination of 3 single-point mutations.

    Could the test be wrong? Is this an extremely serious case?

    • Dr Ben November 5, 2012 at 8:37 pm # Reply

      Alan –

      There is always the potential for lab error. Consider retesting.

      However, there is potential for a 3 point and even 4 point MTHFR mutations.

      Of course, these are very rare.

      I have a few clients who are homozygous for one MTHFR variant and heterozygous for the other.

      This is a serious case – and can be amplified by other potentially existing methylation defects such as COMT, CBS, SUOX, GSTM1, etc

      • Echota February 8, 2013 at 10:26 pm # Reply

        How/where would one go about testing for other potentially existing methylation defects such as COMT, CBS, SUOX, GSTM1, etc?

        Are these one would be concerned about testing for is one is C677T homozygous? Or in general, if one has any mutation at all, or is it only in certain circumstances?

        What test might one ask one’s naturopath for if one would want to test for these?

        • Dolores Seames February 9, 2013 at 1:38 am # Reply

          Check out Amy Yasko also has testing, but much more expensive. Many of us use the 23andme test, and it is very simple, also a lot less expensive than it was when I did it.

          • Echota February 9, 2013 at 6:50 am #

            Thanks! Do you know if one ought to test for them with any/all mutations, or just certain ones?

          • Dolores Seames February 9, 2013 at 3:04 pm #

            You can compare the Yasko’s test with 23andme at mthfrsupport com then go to articles, then to yaskos comprehensive methylation panel or 23andme. Some people do both, but doing that is too expensive for most. The 23andme is tests for most of what you really need, at least to start. It tests a lot more than Yasko’s, but if you still have trouble with supplementing, and not improving, then maybe Yasko’s test would be good. If you are going to test, you might as well do as many as you can, or afford. 23andme is pretty comprehensive. Check out the link for the comparison. This site doesn’t let you post a whole link, so reason for the above partial. You should be able to find it. It is the first article.

    • mary January 22, 2013 at 9:02 pm # Reply

      Ben, “Flushing” is a normal and expected side effect of Niacin, especially if you take an immediate release form. It can happen to anyone who takes Niacin.

      • Dr Ben January 23, 2013 at 8:14 am # Reply

        Mary –

        It is dose dependent. Not everyone flushes at small amounts – everyone is different.

  30. A November 8, 2012 at 11:36 pm # Reply

    Could MTHFR or COMT be a factor in post-SSRI sexual dysfunction (PSSD)?

    Certain people develop persistent sexual dysfunction from SSRIs that persists for years after getting off the SSRIs. Some people are more susceptible than others.

    The mechanism of PSSD seems to involve high prolactin, low dopamine, and gene silencing due to methylation:

    “Some of these gene expression changes are a result of altered DNA structure caused by chromatin remodeling,[37][38] specifically epigenetic modification of histones[39] and gene silencing by DNA methylation due to increased expression of the methyl binding proteins MeCP2 and MBD1.[40]”

  31. Jeff November 20, 2012 at 2:51 am # Reply

    Dr Ben: In a previous post you mentioned that COMT is responsible for metabolizing (lowering) norepi and estrogen both.

    Do you feel that appropriate doses of magnesium & nicotinamide (COMT cofactors) are useful in enhancing COMT enzyme function to lower norepi and/or estrogen?

    Are there other steps (or cofactors) related to methylation, COMT, etc., that you would consider to lower these values if they were problematic (consistently too high)?

    Thanks for your time.

    • Dr Ben November 20, 2012 at 8:00 pm # Reply

      Jeff –

      I am currently working on understanding the biochemistry of COMT and MAOA.

      I do know that Niacin is very effective with COMT and I’ve seen the tremendous benefits it provides in a number of my clients.

      Niacin has to be used cautiously as it can lower SAMe levels too much which we don’t want to do. If that happens, one may supplement with methylcobalamin, methylfolate, magnesium, TMG or SAMe to offset the incidental lowering of SAMe.

      There are other issues with COMT – such as s-adenosylhomocysteine inhibiting it. Methylation has to move forward in order to lower SAH.

      It is a balancing act which requires individuals having COMT and/or MAOA mutations to understand their current emotion and approach it with the right nutrient(s) for that present moment.

      There is no set protocol to take this or that daily for COMT or MAOA – at least not in my book.

      • Jeff November 21, 2012 at 3:56 am # Reply

        What are the cofactors to assist the enzyme SAHH in processing SAH (and moving methylation forward) ?

        • Dr Ben November 23, 2012 at 8:19 pm # Reply

          Jeff –

          Good question and I am still looking into this.

          It is not a simple answer as the production of SAH can occur from various angles and each method of dealing with it varies.

          I want to refrain from answering this currently as I do not want to make a mistake. I will follow up with it though.

  32. christine g November 21, 2012 at 2:02 am # Reply

    do people, like myself, with the a1298c gene defect need to avoid glutamates? I’ve been using glutamine to “heal my gut” and to cut on sugar cravings. And now I’ve discontinued it because I have read that it can be bad for us.

    • Dr Ben November 23, 2012 at 8:22 pm # Reply

      Christine –

      Your enterocytes (intenstinal cells) will use up the glutamine if it is in high demand. If you take too much or exceed what your enterocytes need, then you will take the rest of the glutamine and make glutamate.

      Healing your gut is very important and I’d stay on the l-glutamine powder as long as you feel it is not affecting your anxiety or moods.

  33. argentina mausten November 21, 2012 at 3:49 am # Reply

    Is there a specific diet that should be followed with MTHFR 677?

  34. Johnmac November 23, 2012 at 5:28 pm # Reply

    Dr Ben,

    I think I read somewhere on the site that you’re not into chelation of heavy metals. (Can’t make the search function work, so can’t find it now.)

    Would that be because you feel that once methylation is fixed, we can detox the HMs without chelation?

    What about mercury in the brain? I believe Hg can’t cross the BBB (out, not in) without a chelator attached (alpha lipoic acid being the only one that will do this, according to chelation guru Dr Cutler).

    Your thoughts?

    Thanking you,


    • Dr Ben November 23, 2012 at 8:09 pm # Reply

      Hi John –

      I am into chelation when the individual is ready for it and it is not making them worse.

      I have not read Cutler’s protocol yet – I have his book and intend to read it.

      I have learned that alpha lipoic acid is an intracellular chelator and also helps mobilize mercury from the brain. I’ve also learned in med school to not use alpha lipoic acid until the extracellular load of mercury has been reduced. This makes sense. Why mobilize more Hg when the current extracellular load has not yet been dealt with?

      We also have to realize that many of us have leaky blood brain barriers. I believe if we have leaky gut, we have some aspect of leaky blood brain barriers.

      The use of phosphatidylcholine is very important and you can get this in krill oil or straight phosphatidylcholine supplements. You can also get phosphatidylcholine from liposomal vitamin C and liposomal glutathione.

      Methylation is never ‘fixed’. It can be improved or balanced, but it is never fixed. There are too many environmental factors at play which affect methylation and disturb it. Methylation requires constant balance and a lifetime of work to maintain.

      In short, I believe many can begin to eliminate heavy metals once methylation starts working properly.

      Sometimes one’s methylation cannot work well until chelation occurs because heavy metals inhibit some of the key steps of methylation. Methionine synthase is one big one that is inhibited from heavy metals.

      My biggest fear is people begin to chelate and mobilize mercury from their cells and safe storage sites only to have it end up in their nervous system. This is why I’m not into chelation as there are many physicians who do not do it properly – or safely.


      • Johnmac November 23, 2012 at 8:47 pm # Reply

        Dr Ben,

        Thanks a lot for your response, which is illuminating.

        Will be interested in your response to the Cutler book, when the time comes.

        “I’ve also learned in med school to not use alpha lipoic acid until the extracellular load of mercury has been reduced. This makes sense. Why mobilize more Hg when the current extracellular load has not yet been dealt with?”

        I think Cutler would be right with you on that. His protocol often begins with DMSA or DMPS (or simply time) to clear the extracellular Hg first.

        “We also have to realize that many of us have leaky blood brain barriers. I believe if we have leaky gut, we have some aspect of leaky blood brain barriers.”

        I didn’t know that. How might a leaky BBB impact on (i) mercury going into the brain; (ii) getting it out again with ALA?

        Phosphatidylcholine reduces leakiness of the BBB, right?

        “I believe many can begin to eliminate heavy metals once methylation starts working properly.”

        Do you mean with chelation, or spontaneously?

        Re what to begin with – your methylation/chelation chicken/egg: I’d be interested to learn more on how to know whether to attack methylation first, or chelation first. I did the Cutler protocol pretty hard, knocked myself round, and can’t chelate presently (thiol symptoms I think). That’s why I’m interested in methylation – as a way back into chelation, in addition to the many other benefits I am now learning about.

        Thanks and all the best,


  35. Holly November 28, 2012 at 1:53 am # Reply

    Could there be a connection between blood clotting genes and MTHFR c677t increasing the rate of miscarriage, stillbirth and neural tube defects? Since blood volume and clotting is increased during pregnancy, could it cause low folate to be even less useful because it takes longer to get into the cells? Does the overproduction in PAI-1 and other clotting factors cause the body to work harder and use up more methylation pathways, reducing what little enzyme is left to convert folate to its’ usable form? Maybe that is why someone with MTHFR c677t homozygous with no blood clotting gene or disorder or celiac can have healthy babies no problem, but add in the clotting and/or celiac and problems arise. I have both c677t homozygous and PAI-1 homozygous and have had 2 stillbirths, son had an unknown anomaly of skull, possible cranial bifida or encephalocele and daughter had hydrocephalus and anal atresia. Geneticist at Akron Children’s doubted it was a genetic condition with either one. Normal karotype with daughter, son’s was tested but tissue didn’t grow due to advanced autolysis. I was told not to bother with blood clotting test after I lost my daughter last year because it didn’t cause this, but I didn’t believe them so I went ahead and tested because I found this site! That is why I am asking, could it be that this combo of genes caused me to lose my babies? I think doctors are blatantly ignoring the evidence and research right in front of them, dismissing losses as something that just happens. I just don’t believe it. I thought it could be our water supply and was told no because I would be very sick from bad water. But they forget a tiny embryo is more susceptible to minor toxins than a full grown adult. Please get on the Dr. Oz show and make the whole country aware of MTHFR and how important this is! I had no idea I should have been tested for blood clotting genes before becoming pregnant a second time. I lost my son in 1999 and just lost my daughter in November last year after much hope she would make it. There was also research showing the potential of taking high doses of active folate even during later stages of pregnancy being able to reduce hydrocephalus in utero. I showed the doctors the research I had found and they just dismissed me like I was some idiot. I don’t understand why so many doctors aren’t interested in new research and listening and learning from their patients. Many ideas come from the most humble of places and sometimes they turn out to be right. If more people had open minds, maybe many more problems could be solved in this world! I think a blood clotting panel and an education and awareness about gut health should be given to all women before starting pregnancy. I also think they should take folic acid out of the food supply and if they were smart, they’d add in active folate instead if that would be possible. I ate a lot of pasta and cereal and had no clue I was in fact harming myself and unborn babies because I couldn’t even convert the folic acid properly. I also believe I have celiac but they wouldn’t test me, said it was IBS and stress or from pregnancy hormones. I also had chest pains while pregnant last year and they also dismissed that as stress even though I was having them early on before I knew of any problems with the pregnancy and wasn’t stressed at all. I think it had to do with the gene polymorphisms I have. I recently have taken gluten out of the equation now anyway because I trust my instincts more than anything anymore. The doctors just recommended high folic acid before trying again and never said a word about active l-5 methylfolate or gluten issues or nattokinase or blood thinners. Also can’t get them to prescribe the right folate for me and now I have no insurance, so is metfolin still better that quatrefolic? I have been seeing conflicting statements about the two so I would like for you to re-verify your stance on the best one please! And I have read that vitamin c destroys b12, but does it do the same with folate? Is it ok to take folate with a fruit and veggie green smoothie? Why is there such ignorance in the medical community about these issue? Thanks so much for trying to spread the word and educate us all about this.

    • Shana March 11, 2013 at 4:38 am # Reply

      Holly, I am so sorry for your losses. My heart goes out to you. You have obviously done your homework and deserve a good doc who can help you. Unfortunately, there are few good docs out there who can help us understand this. We are told to take ‘more’ synthetic folic acid, in hopes it will work, instead of even suggestitng activated “natural’ folate, which seems so obvious.

  36. Karolyn December 4, 2012 at 7:13 pm # Reply

    hi-my son (5 yrs old) tested positive for the mthfr gene-don’t have which ones in front of me at the moment. The pediatritioan that tested him believes the gene causes developmental delays in children while other pediatritians have told me no. The first pediatrician reccomended a nutritionist who then suggested to lower his protein in his diet to 20 grams a day. This was actually difficult to do and unfortunately stopped doing it. My question is does this gene have anything to do with autism (it is suggested my son has pdd-nos) and if so, should I try this diet again or any other method to reduce his mild autistic tendencies- more specifically language and social initiation?

    Thanks for your help!

  37. Melissa M December 11, 2012 at 12:20 pm # Reply

    What is the connection, if any between MTHFR mutations and infants/children/adults with tongue ties and lip ties? In addition, recurrence of these defects in those individuals, possibly worse with those who are homozygous vs. heterozygous?

  38. Melissa M December 11, 2012 at 12:24 pm # Reply

    How does one go about determining whether or not an infant has the mutation and would even be “activated” at that stage of life? Is it sufficient, and necessary, to have both parents tested and go from there? If testing is required on the infant, at what age is it appropriate? Lastly, if infant/baby/young child is breastfeeding is treatment possible through the mother’s milk or is some other form of supplementation required to treat and then how do you go about that/what age?

  39. Jessica December 18, 2012 at 6:54 pm # Reply

    Dr. Lynch,

    According to your article “Folic Acid Fortification, Increase in MTHFR and Rise in Autism?”, it is imperative for parents to test for both MTHFR variants prior to conception, and supplement appropriately during the prenatal period. You also mention that depending upon the MTHFR status of the child, proper supplementation is crucial for avoiding autism and other diseases — to not abandon them once they have left the “enriched folic acid of the womb”, but you do not lay out your specific recommendations for doing so.

    Can you please provide your readers, who are desperately trying to provide optimal health for their children, a supplement guideline for infants and children who are C677T (hetero/homo), A1298C (hetero/homo), and compound C677T/A1298C. A chart with each genetic scenario and the suggested supplements and dosages would be very helpful. Also, it would be nice if you would take into account those who choose to breastfeed and those who do not.


    • Dr Ben December 20, 2012 at 6:01 am # Reply

      Jessica –

      There are no specific recommendations as there are no studies done nor is everyone identical.

      Each individual is different, their environment is different and their epigenetics are different.

      It is impossible to provide a protocol for this which is useful for everyone.

      The body is extremely complex and I do not want to simplify it by simply recommending a set protocol for everyone – that is doing a large disservice to everyone – including the unborn child.

      I am working on a book which will provide information how to choose what to do – and how to do it – and it takes a book to do it.

      • Jamie Roberts March 7, 2013 at 10:57 pm # Reply

        Can being a heterozygous MTHFR C677T and A1298C polymorphisms cause muscle weakness? My 1 year old son has this polymorphisms and has been struggling learning how to walk. Should we schedual a consult with you to determine supplementation amounts for him?


  40. Keshia December 20, 2012 at 6:44 pm # Reply

    I am a 26 yr old female and I have suffered from 2 strokes and recently just had a seizure, along with being born with congenital heart disease and having that surgically corrected when I was 13; I just found out that I have the MTHFR gene mutation but no one will talk to me about it and all my health problems still have no answer. I also suffer from sever anxiety and depression.
    Do you believe all these health issues could be from the MTHFR gene mutation?

    • Echota February 8, 2013 at 10:34 pm # Reply


      If you can find a practitioner in your area who understands MTHFR and get tested, it sounds like it would be very worth it. The anxiety and depression also may be helped by 5-HTP, but again, I would find a practitioner (probably a naturopath) to help you suss this out. There are a couple of threads in the forum with recommended practitioners in some areas, and Google might help, too.

  41. Wendy December 29, 2012 at 4:19 pm # Reply

    Hello. I am so glad to have found this site! My three children were just diagnosed: 1st born: C677T heterozygous (11 years old), 2nd: A1298C heterozygous (7 years), and 3rd (10 mos. old): C677T and A1298C. Due to them also having Sensory Processing Disorder and the oldest Celiac Disease, we have a good team of doctors with whom we have been treating food allergies, gut issues, and candida prior to this diagnosis. What comes next after this diagnosis is a cause for confusion. One doctor wants to test and one wants to treat. I am looking for a guide for the next steps for children. Upon diagnosis should you do next? Test for other mutations? Test the methylation cycle? If so on the last one, with whom? Start treating with methylfolate and B12? Avoid foods high in methionine? And on the protein recommendations: they seem to low for growing children. If they are correct, what does a diet for children look like carb, protein, etc.-wise? Many thanks!

  42. Melissa M December 29, 2012 at 9:38 pm # Reply

    In babies with midline defects such as tongue tie/lip tie who have reflux due to that and food sensitivity, etc. – where MTHFR is suspected and/or confirmed – what is proper protocol to heal the reflux?

    • Melissa M December 29, 2012 at 9:46 pm # Reply

      Let me clarify that I am asking about reflux treatment in infants beyond having the tongue tie/lip tie treated, when that has failed or continues to pose an issue. There are many parents who are dealing with this issue. Infants with MTHFR parents who most likely have MTHFR mutations, midline defects, and are suffereing with digestive woes such as reflux and constipation, etc.

  43. Ashley January 1, 2013 at 6:27 am # Reply

    Is it possible that Macrobid Antibiotic, which is contraindicated for persons having “a B vitamin deficiency”, could cause extreme agitation which could lead to unusual behavior such as raging or violence?

    Thank you very much.

  44. Rhonda Barranco January 14, 2013 at 7:53 pm # Reply

    Does having this mutation mean u r also suspect for celiac or just gluten sensitive or intolerant?

    I am just wondering if the genetic test will be positive, even tho the blood test was negative…….

    • Dr Ben January 16, 2013 at 10:03 pm # Reply

      Rhonda –

      No relation between celiac and MTHFR from what I’ve seen.

      Genetic testing for celiac is a good idea.

  45. MF Lund January 16, 2013 at 6:53 am # Reply

    Is there a connection between the MTHFR gene mutation and having myasthenia gravis? I have the mutation, and my brother has MG. I was wondering if he should be tested for MTHFR and that methylated B vitamins might help his MG? I googled this but came up with next to nothing on a connection.

    Thanks, MFL

  46. Ron January 17, 2013 at 1:45 pm # Reply

    Dr. Ben: just finished your presentation and want to thank you for providing this information. Getting my feet wet. I have a couple of questions I hope you could answer.
    1. You mentioned using gentiana as a digestive bitter. Is gentiana effective alone or do other herbs need to included in the bitter solution?
    2. Do you know if consuming nightshade vegetables have a negative impact on the methylation pathway?

    Thanks Ron

    • Dr Ben January 17, 2013 at 6:41 pm # Reply

      Hi Ron –

      1) May be combined with other things. Gaia Herbs has a good tincture of gentiana and wormwood I believe. Gentiana may be used alone – and it just takes a drop or two in a bit of water prior to a meal.

      2) Not sure. Good question. I know chlorogenic acid – from coffee, sweet potatoes and potatoes – have an effect on reducing DNA methyltransferase (DNMT1)

      • Ron January 18, 2013 at 12:40 pm # Reply

        Dr. Ben: thanks for the response. Two more questions if I may:
        1) Where does the male androgen pathway fit in to the methylation pathway, i.e. cholesterol pregnenelone etc. ?
        2) One of the therapies for neurological problems such as Alzheimers is to have the person consume large amounts of coconut oil (medium chain triglycerides). Any ideas on how the MCT’s improve cognitive function in these people?

        Thanks Ron

  47. Eva January 20, 2013 at 2:22 pm # Reply

    Dr. Ben, you list many types of medicines which shouldn’t be taken with a MTHFR deficiency. i do not see any related to the treatment of ADD or ADHD. Can a person take these drugs ( ex. VyVase) safely with MTHFR deficiency or while taking methyl-folate? Thanks, E

    • Viola January 30, 2013 at 11:06 am # Reply

      I wonder about this, too, as my son is on Concerta which helps him function. He has MTHFR homozygous C677T.

  48. Mark January 28, 2013 at 3:05 pm # Reply

    what is methylation, and what does MTHFR stand for?

  49. Ron January 29, 2013 at 8:22 pm # Reply

    Dr. Ben: thanks for all the great info on your site. Very informative. In one of your articles, you wrote “Vitamin C and Methylcobalamin Interaction: When taking methylcobalamin, it is necessary to not exceed ingesting 450 mg of vitamin C concurrently. This is due to the destruction of methylcobalamin when in the presence of more than 500 mg of vitamin C.” Then wouldn’t the 700mg of VC in your Optimal Multi Vitamin destroy the B12? Thanks

  50. Pat February 6, 2013 at 3:27 pm # Reply

    I have been diagnosed with MTHFR (don’t know which one, but I will!) and factor V Leiden. I’m 57 years old and since menopause was diagnosed with an underactive thyroid and take Synthroid. I also have developed several lipomas in various areas of my body. I started a low carbohydrate diet and saw improvement in all of my labs, specifically C-reactive protein and was encouraged. I just learned of your website and am very hopeful that I will be able to receive more information on this genetic mutation. I also now take low dose aspirin each day after the MTHFR diagnosis. I had 4 pregnancies to term with no complications, however, one of my daughters has been diagnosed bi-polar. Can the lipoma, thyroid and my daughter’s diagnosis be caused by MTHFR. If so, can I do anything about it? I am investigating the Specific Carbohydrate Diet, since I’ve seen improvements with lower carbohydrates. Do you believe that would also be helpful. I’ve also bought hydrogen peroxide designed to be ingested at the health food store to put a few drops in water each day. What are your thoughts on that?

  51. Echota February 8, 2013 at 10:46 pm # Reply

    Some questions about the protocol, as It would help very much to understand the reasoning behind these:

    1) Why no gas stoves?

    2) Why no carpets? Is this ALL carpets, new and old? I know the new offgasses like mad.

    3) Why no dairy? Is this ALL dairy, including raw/ grassfed? Is it the proteins or something else? What about ghee?

    4) Wouldn’t chia seeds be a concern for methylation, as they are super high in oxalates? And what about high oxalate foods in general?

    5) Are you familiar with Kangen water? If yes, what are your thoughts?

    6) Is there a cheaper way to do the water with electrolytes part? Like coconut water or something?

    Thanks so much for being such an invaluable resource for all of us.

  52. Cathy February 16, 2013 at 1:04 pm # Reply

    Can MTHFR deficiency cause congestive heart failure? Many of our family members have been diagnosed with this deficiency, and have some kind of heart problem. Please let me know ASAP.

  53. Derrin Hempseed March 4, 2013 at 2:39 pm # Reply

    What drugs are bad for MTHFR? Does methylfolate interact with Tricyclic Antidepressants?

  54. Elizabeth March 5, 2013 at 6:15 pm # Reply

    Thorne Prenatal supplements have Vitamin K in them, which can counteract anticoagulants. How does this affect patients with recurrent miscarriages who are often on baby aspirin, heparin, lovenix, etc?

  55. Jade March 18, 2013 at 3:51 pm # Reply

    Dear Dr Ben
    I love your website, so much information – I was wondering if you would mind please advising me on whether spironolactone decreases folate levels as much as the contraceptive pill does or if it is a bad drug to take for someone with MTHFR mutations? I have PCOS and all my horrible symptoms (depression, chronic fatigue, anxiety) started when I began taking the pill 20 years ago and despite not having taken the pill for 10 years I still feel terrible. I am trying to self-treat using your recommendations but I also really need to do something about my water retention and facial hair! I would like to try spironolactone but don’t want to make my other problems worse. Thank you so much for any advice you can give me.

  56. Marci Sakal March 23, 2013 at 3:18 am # Reply

    If Metformin can lead to high Homocysteine levels, what are the alternatives to this drug? For example, does Tradjenta cause the same problem?

  57. Alaina March 25, 2013 at 4:38 am # Reply

    Should a baby born to a mom with c677t homo be give the vitamin k shot at birth?

  58. Maggie March 27, 2013 at 6:44 am # Reply

    Hi Dr Ben,
    can methylcobalamin be safely used in patients with high mercury levels (from previous amalgam fillings)?
    Or does Mercury steal the methyl group and cause more damage as methylMercury before it can be detoxed?
    Thank you.

  59. Wim March 31, 2013 at 8:08 pm # Reply

    Hi Dr. Ben,

    I am heterozygote MTHFR 1298 and heterozygote MTHFR 677. I thought this would cause low 5-MTHF levels, but I have high 5-MTHF (and low normal homocysteine levels in blood) despite taking 1mg B12 daily.
    What can be the cause of my high 5-MTHF?


  60. trevor elliston April 6, 2013 at 10:28 pm # Reply

    Are then any any known treatments related to MTHFHR C667T which may assist in reducing / controlling symptoms of Autism/Aspergers?

  61. catherine April 10, 2013 at 2:55 am # Reply

    From a recent discussion with my physician as well as reading on this site, I am realizing that I may be making my problems with the MTHFR (homozygous) worse by taking the daily mulitvitamin I have been taking. I am taking deplin, but my multivitamin contains folate as well as B12. Could I be complicating things by taking a daily multivitamin? If so, is there a multivitamin you could suggest?

  62. Ann April 13, 2013 at 2:28 pm # Reply

    Does MTHFR inhibit bone regrowth after a fracture?

  63. Erica Jones April 15, 2013 at 2:25 pm # Reply

    My son has been diagnosed with heterogeneous C677T. He also has been diagnosed with profound dyslexia and Language Processing Disorder. I saw in the symptom list about deficit in childhood cognitive development. Where can I get more information on children having the mutation and learning disorders?

  64. Judith Stringer April 20, 2013 at 12:37 am # Reply

    From Dr. Ben on inflammation: Consider 1 to 2 capsules of 250 mg of liposomal curcumin to help quench inflammation. If one takes methylfolate before inflammation is controlled, the methylfolate will worsen it. One may consider taking 2 capsules of Optimal Turmeric three times a day during times of inflammation.

    I have chronic inflammation. Does that mean I should not take methylfolate? I use curcumin for inflammation.

  65. Brian May 3, 2013 at 4:43 am # Reply

    Dr. Ben –

    Can a C677T mutation cause eosinophilic esophagitis?

  66. Erin Sprinkle May 3, 2013 at 8:37 pm # Reply

    My mother recently tested positive for the MTHFR 1298 heterozygous mutation. Previous to this finding, she was being treated for Lyme disease, but the treatment was not really making her better. To find out why she was still so sick, she had further testing done and came up positive for the gene mutation. I have many of her symptoms. In fact, we have often joked that I am so much like her- we both complain about our aching joints, bad skin, sensitivity to many foods, forgetfulness, migrains etc. I am only 28 years old, and have always wondered why I feel so unhealthy despite being so young. Now that my mother has tested positive for the mutation, I feel that I should also be tested. Should I start with my Primary Care Provider? Or do I go to a genetic councilor, or straight to the lab? Do you have any recommendations of labs I should use? I live in Portland, ME.
    Thanks very much,

  67. Nicholas May 14, 2013 at 3:34 am # Reply

    Hi Dr Lynch,
    I’m a 21-year-old male and I’ve been suffering with Glandular Fever symptoms for the past 18 months. Tiredness, low immunity, malaise, headaches, muscle aches, fever, photophobia ect.

    A recent bout of tests has shown that I am MTHFR A1298C – Heterozygous and I have a history of Glandular Fever and Cytomegalovirus.

    I was very healthful and experiencing very few of these symptoms 18 months ago -am wondering if Glandular and Cytomegalovirus could have brought on more of the symptoms associated with MTHFR mutations? Or, perhaps MTHFR is stifling my recovery?

    Any insight you could provide would be greatly appreciated. Best wishes and thanks in advance,

  68. Drew May 22, 2013 at 2:04 am # Reply

    What form of b-12 is best and why? There seems to be many choices. hydroxocobalamin, Cyanocobalamin, Methylcobalamin, Adenosylcobalamin, Hydroxycobalamin. Which contributes to the Methylation cycle?

  69. Mominmo May 26, 2013 at 8:23 pm # Reply

    What would explain severe hypokalemia after taking very small amounts (1/4 tab of Active B12/Methyl folate)? Significant potassium supplementation doesn’t seem to address the symptoms (excessive thirst, frequent urination, GI distress with malabsorption, itching, muscle twitching, etc.)

    • Caledonia July 26, 2013 at 5:29 pm # Reply

      I recently found out this is due to leaky gut (source: Podcast). Stop methyl supps, and treat leaky gut first. The same problem can happen with magnesium.

  70. Tara June 15, 2013 at 3:11 am # Reply

    Hi Dr. Lynch,
    My 5 year old son is heterozygous C667T & A1298C. I’ve been addressing that for a year now through supplements. I just got the rest of his mutation results from MTHFR Support and found out he is COMT +/-, NOS +\-, CBS C699T++ so I am pretty sure ammonia is a problem. My concern is his neurotransmitter test came back with ALL of them off the charts high. Dopamine, epinephrine, serotonin, GABA, glutamate, taurine, etc. Way above their ranges. His dr put him on the neuroscience calm prt, kavinace, calm g…these supplements have taurine, glycine, GABA. All things he is elevated on his tests. Is this ok? I’m really nervous and have been researching Yasko’s protocol and reading your info on your site.

    Thank you in advance.

  71. Tyler June 17, 2013 at 8:41 pm # Reply

    I am recently diagnosed compound heterozygous with MTHFR, battling chronic fatigue syndrome for 2 years. My Dr. told me he already tested for the methylation pathway because a methylamonic acid test came back normal. My question is whether this is definitive that my methylation cycle is working properly? Should I continue to pursue the MTHFR route or is this a dead end with the above result?

  72. Scott Newman June 29, 2013 at 8:37 pm # Reply

    Can a positive reaction to oral methylfolate be due to increased methylation and not because of the need for methylfolate?

    • Dr Ben June 29, 2013 at 9:43 pm # Reply

      Hi Scott –

      If one has a positive experience from taking methylfolate, it is because methylation increased and it was needed.

      If you want to see how other nutrients work instead of methylfolate, you may consider SAMe, TMG, B12, Choline.

      This way you will be able to see if it was the methylfolate or just increased methylation.

      Keep in mind that levels of methylfolate fluctuate significantly depending on mood, activity, food intake, stress, toxins, nutrient intake, etc

  73. Darlene July 1, 2013 at 6:47 am # Reply

    Received a prescription for Metanx for my double A MTHFR mutation. However, pharmacy filled it with a generic by Vitrus labeled L-METHYL-B6-B12 (NDC 76439-0218-90). Looked at the label online — appears to have the same ingredients as the brand name product Metanx.

    Have you heard anything to the contrary? Should the generic brands be trusted? Would it be “safer” to go with the brand name products?

    Your opinion much appreciated.

    Thank you.

    • Darlene July 2, 2013 at 9:51 pm # Reply

      Received a prescription for Metanx for my double A MTHFR mutation. However, pharmacy filled it with a generic by Vitrus labeled L-METHYL-B6-B12 (NDC 76439-0218-90). Looked at the label online — appears to have the same ingredients as the brand name product Metanx.

      Have you heard anything to the contrary? Should the generic brands be trusted? Would it be “safer” to go with the brand name products?

      Your opinion much appreciated.

      Thank you.

  74. Jill July 2, 2013 at 7:23 pm # Reply

    I just tested positive for two copies of the C677T Mutation (homozygous) and have several general questions….

    What is the false positive rate of the blood test? The test was performed by Kaiser Permanente and sent to the CO Regional Reference Lab.

    I was diagnosed with fructose malabsorption via breat test. Is there a correlation? I am also lactose intolerant…is there a correlation?

    I suffer from anxiety, depression and fatigue – are there certain psychotrophic medications to avoid? Could this be the cause of these psychiatric symptoms?

    Should I go on a dexoz diet?

    Thank you!

  75. Cat July 6, 2013 at 2:45 pm # Reply

    I do not have any issues with gluten (tested with blood and intestine biopsy), however the enriched flour has folic acid and I was told to go gluten free. What is the issue if I eat something with enriched flour? Can I enjoy something with flour or does it damage all the good I have done with detoxing and supplementation? I have C677t…I can’t get a straight answer as to why I should do gluten free due to the folic acid issue. I was also warned to watch the amount of veggies high in folic acid- but that is natural..please clarify the issue so I can make good choices.

    • Dr Ben July 6, 2013 at 6:19 pm # Reply

      Cat –

      Testing to see if you have issues needs to be done by eliminating it for a couple weeks ENTIRELY and then reintroducing it at every meal. If you notice an improvement in how you feel while off, then you know it is an issue. If you notice that you feel something ‘off’ when you reintroduce gluten, then you know it is not for you. This is the gold standard.

      Gluten is known to destroy the tight junctions in the intestine which leads to leaky gut and thus autoimmune conditions.

      In my mind, no one should be eating gluten – none.

      Veggies are not high in folic acid – they may have folate of some form but they do NOT have folic acid. Folic acid does NOT equal folate; it is a form of folate that is synthetic (which is ok) and requires a TON of biochemical steps and enzymes in order to make it usable by the body. Then add on the fact that folic acid increases unmetabolized folic acid in the blood which can depress natural killer cells.

      Flour is bad if it contains gluten. Use quinoa, almond, coconut, rice flours – there may be some others which I am missing.

      • Wim July 7, 2013 at 9:14 am # Reply

        Dear Dr. Ben,

        I have high 5-MTHF levels in blood. Taking 1mg mB12 a day for a long period of time hasn’t helped lower it. What would be the reason for the high 5-MTHF and what else can I do to lower it? (I’m already glutenfree)

  76. sarah July 16, 2013 at 2:58 pm # Reply

    why does the protocol eliminate dairy? why does it require ALL grass fed, free range eggs and meat? why eliminate gluten or wheat if there is no folic acid in it, whether homemade or sprouted?

  77. Barbara C. Smith July 23, 2013 at 3:54 am # Reply

    Does the MTHFR genetic defect cause Creatine Kinase levels to rise at all, as it does homocysteine? Thank you.

  78. Dr. Erika August 7, 2013 at 5:56 pm # Reply

    Hi Dr. Lynch, so glad for all the information you put out.

    I work with a LOT of postpartum depression patients and have started screening them for SNPs, in addition to screening for other concurrent depression-mimicking disorders – can you speak to the safety of using high-dose B vitamins and other MTHFR treatments (betaine, SAMe, etc, etc) in nursing mothers? (I realize that B6 can suppress lactation)

  79. Gwen Brown August 18, 2013 at 2:32 am # Reply

    Would you please go over the different forms of anesthetics that are harmful or would be preferable for those with MTHFR mutations? Thank you.

  80. Denisse August 27, 2013 at 10:21 pm # Reply

    Hi There

    Is there a link between MTFHR and high prolactin levels and/or pineal cysts/tumours?

    Appreciate if can advise where to find this info


  81. J February 18, 2014 at 9:49 pm # Reply

    Is it safe to begin taking folate in vitamins (have MTHFR mutation) while nursing?
    Would a detoxifying affect be safe?

  82. Jackie March 16, 2014 at 5:24 pm # Reply


    My grandmother and mother died at ages 39 and 54, possibly due to MTHFR. My Uncle was diagnosed with it after he passed a complete physical, then shortly after had a major heart attack. He took his folate as directed and died at 57.
    Interestingly, my Uncle, mother and grandFAther all had brain tumors. I’m not sure if there are any correlations between MTHFR and tumors. (Especially when the MTHFR probably came from the Ashkenazi side, not Grandfather’s. They seem to have more health issues and die younger.)
    One cousin is homozygous, while I have C677T only. Nobody else will get tested, they believe if there are no symptoms, there is no problem.
    I’m fairly in agreement “if it ain’t broke, don’t fix it.” We may not have the same fate as our parents.
    However, we seem to be predisposed for specific health issues and premature death.
    The debate we’re having is: why would one get tested or take medicine if it doesn’t appear needed?
    Doctor says 50% of the population has the MTHFR mutation and 30% of them don’t need to treat it.
    So, are we treating symptoms or mutations?
    I would think you treat the cause to eliminate the effect.

  83. Cherry April 20, 2014 at 9:03 pm # Reply

    Is Leucovorin Calcium ever recommended for those with MTHFR defects and if so, why?

  84. Ashley Sutton June 6, 2014 at 2:04 pm # Reply

    Is general anesthesia safe for ages two and under with homozygous C677t? Does it increase learning disability and autism risk? Is a local anesthesia a better choice?

  85. kris June 7, 2014 at 6:41 pm # Reply

    Which form of vitamin B12 is best? Why? Where can I go to get more information? (What are your sources? ) Thank you. k

  86. Melinda June 26, 2014 at 12:55 am # Reply

    I am hetero for C677T and have a bad reaction to b vitamins and unable to take them. My doctor doesn’t know much about mthfr but prescribed natural food vitamins (either Standard Process or Garden of Life Kind Organics to get the folate and b vitamins I need. Am I correct in the fact that the C677T makes it important to get the folate to the brain and will this work as the methylated and regular do not? How much does one need? Thank you!

  87. Beryl Moors June 26, 2014 at 5:34 pm # Reply

    I am trying to heal leaky gut. If I have MTHFR defect, can I still take the supplement L-Glutamine?

  88. barbara smith June 28, 2014 at 7:46 am # Reply

    No you cannot take L-Glutamine with a positive MTHFR. It is an excitotoxin and will not serve you well at all.

    • Dr Lynch June 30, 2014 at 6:33 pm # Reply

      Barbara –

      That is not a true statement. People with MTHFR can take glutamine. Glutamine can convert to glutamate which is an excitatory neurotransmitter. It is not an excitotoxin. Glutamine is a very important nutrient for many people. In the gut, it gets used first. Taking the right dose is important. One can convert glutamate to GABA by using magnesium and B6.

  89. Melinda June 30, 2014 at 6:48 pm # Reply

    Help please! I am pretty desperate here. I react badly to b vitamins methylated or regular. They make me feel irritable and crazy. I tried whole food vitamins and they aren’t any better. Can anyone tell me what to take? Single mthfr and my son who is double reacts terribly also.

  90. Barbara Smith RN CCM July 1, 2014 at 12:15 am # Reply

    I guess it depends on who you ask. Dr. Nancy Mullan and Dr. Amy Yasko state that those with MTHFR cannot take L-glutamine because it’s an excitotoxin. Apparently there are differing opinions on this topic.

  91. Trisha Loomis August 15, 2014 at 3:46 pm # Reply

    My friend has the mthfr mutation C677T and she has been told her not to eat foods high in Vitamin K like kale due to blood clots. Is this a correct? He also had her on high doses of folic acid. I told her to stop that and start taking folate.

  92. Mara September 12, 2014 at 7:17 pm # Reply

    In one of your articles you mentioned to take Vitamin C at least 30 minutes away from Folate. What about extended release / time release Vitamin C (1000mg)? Would that hurt Folate more because it’s being absorbed throughout the day, or is it safer because it’s not a large amount at one time?

  93. Michelle September 30, 2014 at 9:48 pm # Reply

    Hi Dr. Lynch,

    I just got my labs back for B12 and it was out of range on the high end. I am not taking that much. I am taking your B complex from seeking health. I think I read somewhere that it could be an absorption problem? I am homo for MTHFR and working so hard to where I can tolerate more folate. I suspect that I have some chronic infections but since I am so sensitive I am afraid to do any chelation. Which is probably something I should ask in a second email- sorry.

    Vitamin B12 range/ 211 – 911 pg/mL my result/ 1115

  94. Lynn October 21, 2014 at 4:55 pm # Reply

    Overmethylation and undermethylation seem to have overlapping symptoms. How is it confirmed which is taking place?

  95. Gwen Schneider October 27, 2014 at 2:22 am # Reply

    What do you think about the new transdermal methylation creams?

  96. Stephanie January 15, 2015 at 12:04 am # Reply

    I keep reading that there are potential drug toxicities with the MTHFR. I see articles on antacids, methotrexate, nitrous oxide, and anti-epiletics. I know I have seen other information, especially with regards to antibiotics but not sure where. I had severe life altering reactions to Cipro. I am homozygous C667T.

    It seems like Macrobid shouldn’t be given to people with low vitamin B??? And that sulpha drugs won’t be processed well??? I believe I read anethesia might be harder for some. Is there a list of medications to avoid and suggested safer meds? This would be extremely helpful as I suffered from UTIs in the past and terrified of taking medications after my last incident. I would like this info for myself and also my cousin’s children suffering form the same thing.

  97. Viola Newman January 15, 2015 at 10:05 am # Reply

    I’m interested in the answer to your question. My son is homozygous C667T also.

    He cannot take any kind of antibiotic at all without an allergic reaction. So far, my cure for this has been to keep him away from the doctor! When he is sick, I use herbs and foods for antiviral and antibacterial properties like. But it scares me if he should ever be hurt or have a really bad infection and in the hospital. He had many antibiotics as a young child and reacted badly to each one within a day or two of starting them.

    He is almost 12 and hasn’t had an antibiotic since he was 6.


  98. michelle March 14, 2015 at 2:20 pm # Reply

    i have lyme disease and biploar. my physc doc just hapened to to this test call mthfr. what does this mean. he wants to put me on deplin. i wrote in my lyme group and some people told me not to take it. would the deplin help me? what kind of doc should i be working with for the mthfr gene?

  99. Diane April 15, 2015 at 4:16 pm # Reply

    I need to know if Folinic acid is bad for me to take. I am taking Leucovorin Calcium 10mg. Is it helping me or hurting me? Is Folinic acid, another word for Folic acid? All I have read about my folate defiency is to not take folic acid. I am on a low income and I can’t afford expensive folate supplements. Which brand do you recommend that is affordable(no more than $15.00) and what is the recommended mg.or mcg. that I need. I was diagnosed more than a month ago and I am still not feeling better. Please help me as soon as possible. I need to be able to function again. Thank you very much!

    • Aron Choi April 16, 2015 at 11:54 pm # Reply

      Diane, it depends why you were prescribed Leucovorin by your doctor. It’s often prescribed to address the side-effects of anti-folate antagonists, like methotrexate. If you are experiencing symptoms, you may want to discuss with your doctor.

      Folinic acid is NOT the same as folic acid. Folic acid is a man-made form of folate and not easily converted into the form your body needs. Folinic acid is a naturally occurring form of folate in food, especially leafy greens.

      Dr. Lynch has an extensive explanation here with some action steps at the end of the article:

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