MTHFR Study – Recruiting Volunteers


Location:

Seattle, Washington – Lynnwood/Northgate area.

Background: 

Folates are essential cofactors in the regulation of the transmethylation cycle, and have received an increasing level of clinical research interest as the understanding of genetic and nutritional influences continues to grow, yet little has been recently established relative to the optimal attainable blood levels of the folates. This study will provide additional insight as to the expected plasma levels of folic acid, folinic acid and primary metabolites – tetrahydrofolate (THF) and 5-methyl-tetrahydrofolate (5-MTHF) – in a fasting state, and following supplementation with a known concentration. Laboratory methods have been developed to provide additional insight into the metabolic process of the folates and their effect on amino acid metabolism. The intent of this study is to permit clinical laboratory validation of the associated reference intervals of the folate metabolites in the blood of volunteers who have a previously determined genetic trait for the production of an enzyme responsible for folate metabolism, and to study the effects of folate supplements on subsequent amino acid production. The supplements provided will not be used to diagnose, treat, mitigate or cure a disease or health-related condition, and the results from the laboratory testing will not be used to direct or manage the treatment of the trial participants.

 

Basic Framework: 

The study will consist of 7 in-office visits over the course of 9 weeks. Visits will be conducted at Dr. Anderson’s clinic Advanced Medical Therapies in the Northgate area. 

Visit

Collect blood samples

Regimen – Randomized

Instructions to patient

1

None

None

Discontinue all vitamin supplements. Complete 7-day diet diary. Return in 1 week. 

2

Fasting, then 90-min after supplement

Supplement A (or B or C)

Take 1 capsule/day; return in 2 weeks

3

Morning sample after 14-day regimen

Complete assigned regimen

No supplements; return in 1 week

4

Fasting, then 90-min after supplement

Supplement B (or A or C)

Take 1 capsule/day; return in 2 weeks

5

Morning sample after 14-day regimen

Complete assigned regimen

No supplements; return in 1 week

6

Fasting, then 90-min after supplement

Supplement C (or A or B)

Take 1 capsule/day; return in 2 weeks

7

Morning sample after 14-day regimen

Complete assigned regimen

Participation Complete

*40mL blood is collected on visits 1, 3, and 5; 20mL blood is collected on visits 2, 4, and 6 for a total of 180mL

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27 Responses to “MTHFR Study – Recruiting Volunteers”

  1. Lisa January 28, 2017 at 12:43 am #

    I would like to do this but I’m in the U.K.

  2. Mardrey Swenson January 28, 2017 at 4:27 pm #

    Where is this located?

  3. Mary-Jane K. January 28, 2017 at 5:41 pm #

    Ben,

    I just now posted information about the study on Phoenix Rising and a Seattle CFS/ME Yahoo group.

    It would be helpful to state that “the Northgate area” is in the city of Seattle, Washington. Otherwise, the location isn’t clear unless you go to the trouble of researching where Advanced Medical Therapies is located. You might get inquiries from all over the world unless you make this clear.

    Hope the study goes well.

  4. Carole Berg January 28, 2017 at 6:17 pm #

    Am willing to participate, but am 63. I was diagnosed before 60 though. Let me know. I have been taking B supplements for the years since diagnosis however.

  5. Ed January 28, 2017 at 9:00 pm #

    In what state is the study being conducted; i.e., where is Northgate? Thanks.

  6. Valarie Clark Sobolewski January 29, 2017 at 1:45 am #

    Submitted information to Study Coordinator through email. 3 siblings – all genetically positive – available but on the upside of the age criteria. Awaiting response.

  7. Camelia January 29, 2017 at 7:56 pm #

    I am very interested. I have compound heterozygous MTHFR, my Dad homozygous 677 and my only sibling died at age 47 due to a PE. My homocysteine level is elevated and my Dad has had a PE with elevation of homocysteine. I have been to two hematologist and my other doctors are unfamiliar with how to treat this. I am a female age 48 and was diagnosed about two years ago. Please consider me for this study. I would like to know more about proper treatment for MTHFR. One hematologist encouraged the use of folic acid. More medical professionals need to be aware of this mutation.

  8. Heidi A. January 30, 2017 at 5:27 am #

    Would love to participate but I am in Canada!

  9. Vicki January 31, 2017 at 2:49 pm #

    I am willing to participate, if location isn’t an issue.

  10. Jan February 3, 2017 at 7:01 pm #

    I am willing to participate.

    • Dr Lynch February 24, 2017 at 2:21 am #

      excellent! please contact them and they’ll direct you to next steps! Thank you!

  11. Lisa March 9, 2017 at 7:53 pm #

    I would love to participate,but I live in the St. Louis area. I am compound heterozygous.

  12. Ann March 10, 2017 at 6:45 pm #

    Dr. Lynch,
    I have just come across this information and have soooo much to process!!! I have sooo many of these syptoms. I want to be incontact with someone and want to help. However, I am currently pregnant with an anencelaphic baby girl. I am 42, have had 6 miscarriages, have the butt “dimple”, liver detox issues, food intolerances, and there is so much more! Please contact me on how to proceed!

  13. Dom March 14, 2017 at 12:48 am #

    I hope this study takes Vitamin D into consideration, levels seem to be always depleted in many 677+/+ sufferers.

  14. Monica Glover March 18, 2017 at 8:48 am #

    I am Compound Heterozygous: and on paper the picture of healt. I found out about 4 years ago and can absolutely feel both physical and mental negative health issues. I don’t fit into the normal MTHFR model either. I have 5 children from four very healthy pregnancies and have never miscarried. I’ve suffered from insomnia for about 15 years and have very poor gut health. I’ve experimented with various vitamin combinations and diets with some success sometime, but rarely lasting. I’d love to be in your study, but am out of state and am not clear if you are excepting those outside of WA.

  15. Richard March 23, 2017 at 7:06 pm #

    I would like to participate but i live in SC.

  16. Kyndra April 3, 2017 at 5:37 pm #

    I would like to participate in your study

  17. TARA HERRING April 26, 2017 at 12:54 am #

    I would like to participate but I live in Midland, Texas. I have two copies of A and C.

  18. Shanon May 10, 2017 at 7:29 pm #

    I have two copies of the C677T gene. I also have spina bifida occulta. I have other issues with my blood as well which is how I found that I have this gene mutation. I will be seeing a hematology doctor soon. Is this research study still going on?

  19. Kelley Palomino May 17, 2017 at 9:12 pm #

    I’m willing. I know without a doubt I have MTHFR but haven’t been tested yet. Let me know – also believe my 10 year old daughter has it and a blocked CBS pathway. 2 others of my 5 children may also have MTHFR. One is ocd and one has dark under eye circles. We all should be tested but its too overwhelming. Right now, I need to focus just on myself and my little girl.

  20. Kelley Palomino May 17, 2017 at 9:14 pm #

    I’m willing. Im near Olympa WA. I know without a doubt I have MTHFR but haven’t been tested yet. Let me know – also believe my 10 year old daughter has it and a blocked CBS pathway. 2 others of my 5 children may also have MTHFR. One is ocd and one has dark under eye circles. We all should be tested but its too overwhelming. Right now, I need to focus just on myself and my little girl.

  21. Connie hilbmann May 18, 2017 at 7:56 am #

    I would love to participate I was diagnosed in my late 20s, I almost died during my pregnancies and we were planning IVF and they found it in a genetic panel I’m not sure which mutations I have as my primary docs don’t pay much attention and say it’s nothing to worry about. I do have to be on Lovonox when traveling in car more than six hours and when I have surgery I have to be on for 6 weeks. I’m about two hours from Seattle.

  22. ann May 19, 2017 at 2:21 pm #

    I am willing to participate. My mother 83 improved her hashimoto’s with NAC, D3 and homocysteine factors (pure encapsulations), My sons and I also have signs of methylation problems.

  23. Brianna June 7, 2017 at 10:08 pm #

    Is there a specific time frame that this study will be done? I am interested but currently pregnant.

  24. Parastoo June 15, 2017 at 3:53 pm #

    I would love to participate but I live in Toronto, Canada.

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