MTHFR Test Options? Oral Swab, Blood Test or Saliva

Now that MTHFR is gaining awareness, more options for testing are popping up.

The best option is to have your healthcare professional test you for MTHFR.


It is the easiest and fastest and – more importantly – it may be covered by your insurance.

If your healthcare professional will not do the MTHFR Test, then there are three options for you that I trust.

The three options I recommend for the MTHFR Test are:

1. Spectracell Labs MTHFR Test

  • Sample: Blood
  • Blood draw needed
  • Turnaround time: typically 1-2 weeks depending on results delivery method (general mail or electronic)
  • Price: $140 or so
  • Tests for MTHFR A1298C and MTHFR C677T
  • International availability. USA customers have prepaid return shipping label. Overseas customers must pay for self for return shipping.
  • Find a physician to order MTHFR Test by Spectracell here


2. Molecular Testing Labs MTHFR Test

  • Sample: Cheek Swab
  • NO Blood draw needed
  • Turnaround time:  3 to 5 days
  • Price: $199 or so
  • Tests for MTHFR A1298C and MTHFR C677T
  • International availability
  • Find a physician to order Molecular Testing Labs MTHFR Test here


3. 23andMe Test

  • Sample: Saliva and Cheek Swab (for infants and young children)
  • NO Blood draw needed
  • Turnaround time: 6 to 8 weeks but may take longer due to volume
  • Price: $99 for first test and 20% discount for additional tests
  • Tests for MTHFR A1298C and MTHFR C677T and various other MTHFR snps PLUS numerous other genetic polymorphisms
  • International availability for many countries
  • Order the 23andMe Test here

How to get the 23andMe Test to show genetic information:

When your results come in for the 23andMe test, you will not find the MTHFR listed. You will have to download your ‘raw data file’ and run it through one of two websites:

  1. Genetic Genie: for a donation, they run your 23andMe raw data into a report which has a limited number of genes reported for you. The report is well laid out. Results are available immediately.
  2. MTHFR Support: for $20, they run your 23andMe raw data into a report which has well over 100 genes reported for you. This report is broken down into various categories. I have provided MTHFR Support some of the findings from my research which they have added to their report. I believe identifying some additional methylation, mitochondrial, detoxification and neurotransmitter genes are important. These have been added to the report. The results are available immediately.

Which test is the best option?
The best option for genetic testing, I believe, is the 23andMe Test.


Simply put, there are more genes than the MTHFR gene in the human body.

Identifying the MTHFR polymorphism is important – absolutely. However, identifying, and addressing, additional genetic polymorphisms is even more important.

If you need to know right away if you have MTHFR, then the best option is to order the MTHFR test through your healthcare professional.

Ethical considerations:
Ordering the MTHFR test does not have really any ethical considerations. It simply looks at a couple variations in the MTHFR gene and reports those two back to you.

Of course, one may be shocked and alarmed when finding they have the MTHFR defect; however, after reading the various articles here on MTHFR.Net, one should immediately begin to understand that having the MTHFR mutation is not something to be alarmed about – rather it is something to address and begin improving your lifestyle for the better.

When ordering the 23andMe test, this definitely has some ethical considerations as it provides findings in many genes – including BRCA (breast cancer risk) and APOE (Alzheimer’s Risk). The beautiful thing, though, when ordering the 23andMe Test is that you are able to begin addressing the genetic issues – and discovering possibly why you are experiencing various symptoms.

I can tell you right now – that once you get your report from Genetic Genie or MTHFR Support, you will be initially overwhelmed – and so will your doctor when you plop that report on their desk.

Currently, I am working hard on making a training course for physicians – and the general public – which will help guide treatment plans.

There are many online courses available now here at Seeking Health Educational Institute
for both layperson and health professional.

119 Responses to “MTHFR Test Options? Oral Swab, Blood Test or Saliva”

  1. Steve Thompson July 4, 2013 at 1:59 am # Reply


    I tried the 23andme test. They emailed to say that they could not recover sufficient DNA from my saliva sample to test. So they sent another kit, but the same result from the second sample.

    I’ve now ordered the Yasko methylation test. You didn’t mention that test in your list. Any reason?

    Thanks, Steve.

    • Dr Ben July 4, 2013 at 8:33 am # Reply

      Hi Steve – only because it is more expensive, takes a long time to get results typically and it doesn’t test nearly as many genes as 23andMe

      • Becky July 9, 2013 at 8:05 pm # Reply

        Dr. Ben I have my results and my kids, from 23and me, what do I do now, you mentioned that you could look at them for a donation? Please tell me how to proceed.

        Thank you,

      • Karen von Merveldt-Guevara July 16, 2013 at 2:00 am # Reply

        Hello Ben, I’m a Western trained German MD, yet work in alternative, orthomolecular healthcare in Sedona, AZ. I work consistently with Yasko’s test on methylation cycle issues my patients have. She provides the only test that gives a comprehensive roadmap and takes the guessing out of other cycles that tie into the folate and neurotransmitter cycle. The $495 her test costs are absolutely worth it. The severity of symptoms some of my patients have do not give much leeway for experiments with MTHF only. Yasko’s test provides accurate data as to how the transsulfuration pathway and the methionine cycle work, how BH4 (neurotransmitter) cycle, MAO A and COMT, and urea cycle are performing. I wished Genova Diagnostics Detoxigenomic Phase 2 test would be added, but you can’t have everything! : ) I think you should mention Yasko’s test on your website, it has the highest quality, 23andme does not provide the same, their SNP’s do not -provide the coherence “roadmap” Yasko delivers.

        • K Knack September 17, 2013 at 1:13 am # Reply

          I am also wondering why Dr. Ben does not recommend Amy Yasko’s test. Also, wondering what parts of her protocol he agrees with. It seems that Amy Yasko and Ben Lynch are the two main on line sources that are bringing info to us less informed about MTHFR. It is a very complicated diagnosis with few physicians that know about it or are interested in taking the time to know about it.

          • Karen von Merveldt-Guevara September 17, 2013 at 7:31 am #


            …is a link to Dr. Roberts’, the “Heartfixer’s”, website. He covers methylation cycle, MTHFR impairment and a very important aspect that I do not find as thoroughly dealt with by Yasko: the sulfate and sulfite “high” patient.
            Btw I lately had a patient submit her 23andme generated test results that she filtered through a website called Genetic Genie which allows to take 23andme results and filter them to present most SNPs tested by Yasko and most SNPs tested by Genova Detoxigenomic test. With 23andme NOS though is missing which is an important enzyme to understand mostly in people with high inflammation and lipid metabolism disturbance, and SOD1 SNPs are missing in comparison to Genova Detoxigenomic’s Test… maybe others, those stood out to me.

  2. Marlane Bassett July 11, 2013 at 3:51 pm # Reply

    When you say the best option is to have your doctor do the test which test are you referring to. I am an ND and am aware of the detoxigenomic profile by Genova and after listening to your webinar last night will consider other Genova tests. Which test do you think is the most useful for doctors to order for their patients?
    Thanks for the great class last night – overwhelming but great info! Hoping to get to the October event

  3. marti August 6, 2013 at 3:59 pm # Reply

    The 23andme test DOES NOT list MTHFR as an item tested for in their online information listing.

  4. Sara August 8, 2013 at 6:21 pm # Reply

    Hi Dr. Ben,
    My doctor tested me last year and I came back heterozygous c677t. She immediately put me on 15 mg of deplin. A year later and I feel anxious, foggy, irritable and out of it. My doctor told me it’s just hormones but I am beginning to think it has to do with my deplin. Could this be possible? If so I’m struggling with what protocol to use since I will be doing this all on my own without a doctors help.
    I also did a DNA test through 23andme. I do not see any information on my results about mthfr. It’s not under conditions or traits and when I search for it nothing comes up….maybe you can give me more guidance…
    Thank you!

  5. Heidi Velez August 13, 2013 at 3:13 am # Reply

    About two weeks ago I found out I am heterozygous A1298C/C677TI. I’ve since had my 20 yo daughter tested and she is identical to me. My 17 yo daughter is being tested tomorrow. I was wondering if its possible to test for other SNP’s relevant to MTHFR without getting as “thorough” as the 23 & me test. I am somewhat overwhelmed by the idea of the BRCA and APOE information. I suspect I will be ready to delve into that in the future, but would like to just focus on MTHFR right now. In the past two weeks I’ve made educating myself about MTHFR a real priority and feel like its best to know early in the game if I need to support other aspects of the methylation process. Does anyone have any info that may point me in the right direction?

  6. MB September 20, 2013 at 2:04 pm # Reply

    Dr. Ben,

    Like Heidi, I think you do a disservice to not discuss the possibly disturbing aspects of discovering APOE and BRCA genes, etc., among others. There is usually a good deal of self understanding in wanting to know if one has the much higher propensity of significant disease that may have severe or non-available treatments at present. Of course it’s always better to know the devil you have vs the devil you don’t, so I see the benefit, but to not address the psychological aspects of this is a huge miss.

    The discussion of the lack of the NOS genetic factor is relevant to me. I myself have microvascular ischemia, so understanding the MTHFR gene and NOS are interrelated. Could you advise how to test for it the 23&me, or would it be a different version of the test (including the $495 test that others mentioned)? Thank you

    • Steve Thompson September 22, 2013 at 10:34 am # Reply


      Comparing the Yasko and 23andme dna tests,
      Yasko doesn’t test ACE Del16, CBS I278T, COMT P199P, MTHFR P39P, MTRR A664A, VDR Bsm,
      23andme doesn’t test BHMT-01, CBS N212N, MTRR S257T, NOS-3 D298E, SUOX S370S.


      • Kim September 29, 2013 at 4:44 pm # Reply

        Also, 23andme tests for MAO B and the Yasko test doesn’t have that. This is important to me because we have a son with schizophrenia and we had the yasko test done on him and found he has a lot of comt ++ mutations, he has the MAOA mutation (which is on the X chromosome, so that’s the only copy he gets) but I had 23andme done and I have one copy of the MAOB mutation and I would like to know if he has it because it also breaks down dopamine, along with MAOA and comt. (We are getting 23andme on our other 3 children so I will be able to figure out if he has it without getting him tested with 23andme, but I might still do it anyway, now that it is such a reasonable price.)

  7. Karen Best September 22, 2013 at 12:39 am # Reply

    To those who keep writing in to say 23Me doesn’t include MTHFR … go back and READ the whole bit about the testing. The dr. states it doesn’t include the info AND tells you how to get it.

  8. Jennifer September 22, 2013 at 12:23 pm # Reply

    After reading a lot of the information on this site, it looks to me like Dr. Ben is just here to sell overpriced genetic testing that he apparently gets a kickback from. If it looks like a duck, walks like a duck and sounds like a duck…all I can say is QUACK,QUACK, QUACK!!!!

    • Dr Lynch September 23, 2013 at 5:02 pm # Reply

      Hi Jennifer –

      You are entitled to that opinion.

      I am ready to be challenged by all – and the more respected my work becomes, the more negative attention I will receive.

      I want to congratulate you.

      You are the first to publicly call me a quack to my face – so I commend you for that.

      Yes, I make money from selling health products via my company, Seeking Health. I could just do that and not do any research or provide information to the masses – instead, I believe the research I am doing is life changing and so many others.

      If you don’t, feel free to leave and ignore all the well-researched information here which may significantly help you or a loved one.

      Your choice.

      If you spent one hour listening to some of the podcasts or videos, instead of just yelling, “quack” – perhaps you’d think otherwise – or you may be too set on it and that’s fine.

      Dr Lynch

      • Jennifer September 30, 2013 at 1:50 am # Reply

        Maybe if you had graduated from a real medical school, not one that is on the “accredited but NOT recommended list, I would take you more seriously. Visit

        for more information on Bastyr University. And is a Doctor of Naturopathic Medicine a real physician? Are you licensed to practice medicine in your state? Can you prescribe medication? All meds or do you just have limited prescribing abilities like a PA?

        I could get an online doctorate in any subject and call myself Dr. Jennifer. Does that make me a medical authority? Or a quack?

        • Dr Lynch October 1, 2013 at 12:11 am # Reply

          Jennifer –

          Quackwatch? Really?

          Define ‘Real’ medical school. One that has science boards and clinical board exams that are approved by my state? Done. One that is accredited? Done.

          Yes – I am a ‘real’ physician.
          Yes – I am licensed to practice.
          Yes – I can prescribe medication (but I choose not to).
          Yes – I can prescribe meds – but not including higher interventions without obtaining stronger prescribing rights – which I could if I choose to – but I do not.

          If you get an online ‘doctorate’ in naturopathic medicine, it would be illegal for you to call yourself ‘Dr Jennifer’ in many states. We are working hard to eliminate this problem but these groups have a ton of money and lobbyist power.

          In WA state, you could not practice medicine if you received your online ‘doctorate’ and you’d be put in jail for calling yourself Dr Jennifer.

          Don’t waste my time anymore – or yours – by hovering around and being negative.

          If you want to learn about MTHFR off this site – read the drug package inserts about methylfolate.

          If you get side effects from it or want to learn more, then I guess you’ll have to listen to Quack Lynch. Or struggle through them yourself which you are welcome to do.

          I would love to have some time to write for a grant and be sponsored – but at the moment – I don’t have time. Want to write one for me?

          Yes – my research flies in the face of most current mainstream medicine – but it doesn’t disagree with most research – as that is exactly where I get my information.

          If you read my recommendations – most are cited from the actual research – which you have likely not taken the time to read. I have.

          Enjoy writing your negative comments.

          I’ll keep writing. Maybe I’ll even dedicate my future book to you.

          Dr Lynch

          • Becky October 1, 2013 at 1:03 am #

            Dr. Lynch,

            You know the old saying, “You can’t please all the people all the time”. Please don’t let those who can’t resist criticizing, waste your energy. The information you provide has been priceless to me. Your supplements are amazing, and some of the only ones that do not make my daughter ill.

            We recently found a new Naturopath who did some amazing tests on her and detoxes using (cover your eyes Jennifer) LED, and other therapies. We found that she had a thick lining on her intestines and colon that was preventing her body from absorbing most of the vitamins and supplements we have been trying over the years. The reason I’m bringing this up is because she did a 8 day liquid diet cleanse from Heavenly Herbs, and I would not have believed it if I had not seen it with my own eyes, but she passed all together about 10 feet of what looked like the shape of the intestines with the consistency of a rubber band. After the third day, when it stopped, she said “Mom, I don’t have any joint or muscle pain.” The next day she got up and had energy for the first time in about 10 years. It has been a week and it is like she is a new person. This is a 23 yr old girl, who the top MD’s in several states could not make progress with. Some even told her that there was nothing they could do for her.
            Now we are going to begin to strengthen her liver, with Milk Thistle and Taurine (from Seeking Health). Please if people cannot get better, it may be because they have this plaque buildup, like in the arteries, only it’s in the intestines. This has truly been a miracle for my daughter.
            Thank you for all You do.
            God Bless you

          • Ed October 2, 2013 at 1:12 am #

            I don’t know why you;re wasting your time replying to this Jennifer character. Regarding Quackwatch, on 25 June, the tables were turned on Stephen Barrett.



            for the details.

          • Dr Lynch October 2, 2013 at 7:41 pm #

            Hi Ed –

            I try to explain allowing people to consider changing their radical ideas. I like to give everyone an equal opportunity. If she still refuses based on what I’ve said, that is fine. Case closed.
            If I planted a seed that there may be actually some truth to what is being said – then I’ve done my job as a physician – after all, ‘Doctor’ comes from the word ‘docere’ which means ‘to bring out, educate’

            Quackwatch was something else – talk about a lifestyle of pure hatred. Sad.

          • Jennifer December 1, 2013 at 3:21 am #

            Awwwww, poor Dr. Quack! Looks like the Feds are taking away your little income stream. How sad. Looks like I’m not the only one who thinks your so called genetic test is just a money making scam designed to frighten gullible people. Bwahahahhahahahahhhaaaaa!!!


          • Dr Lynch December 3, 2013 at 7:43 am #

            Hey Jennifer –

            My little income stream? Seriously? Yep – it is all about that. You nailed it.

            Never mind my passion for reducing incidence of disease in unborn children –

            You are something else.

            I love people and comments like yours – because at some point you will face reality (hopefully) and realize that health is way more than medications and surgeries.

            If you don’t – well – good luck.

      • Ed October 5, 2013 at 7:01 pm # Reply

        Dr. Lynch,

        Do you consult to individual patients anymore and if not, could you recommend someone to me in the New York area. My wife is immuno compromised. She has MS (in remission), exema, allergies and an MTHFR mutation and we’re thinking of trying to have a child. Thank you.


    • Daniel September 23, 2013 at 5:52 pm # Reply

      If you had really read a lot of information on this site, you’d realize that Dr. Lynch spends a good amount of time providing education and research to the public for free. He also provides very affordable testing as well as nutraceutical solutions. Would you prefer that he not make a living while doing it? He deserves every penny he gets back from offering people an opportunity to radically transform their life. Good lord, as someone in the health field i’m stunned how many people out there think that health care professionals should practically work for free. Quack and call names all you says a lot more about you than it does Dr. Lynch. Tell us, Jennifer just what are you doing to help people reclaim their health besides duck hunting?

      • Jennifer September 30, 2013 at 1:43 am # Reply


        I have read most of the information on this site. And even more literature by legitimate researchers of MTHFR. None of those researchers peddle test kits. Dr. Lynch’s recommendations fly in the face of most current research available. Since the discovery of the MTHFR gene is relatively recent, there is little research available. As more time passes, we will see if Dr. Lynch’s advice holds any merit.

        As far as making a living, other researchers are paid by the medical or academic institutions for whom they work and by grant money. Those engaging in true scientific research DO NOT spend their time worrying with the minutiae of trying to sell cheap test kits on the internet. I believe that he would be taken much more seriously by the scientific community if he stuck to proven study methods and left the testing to the individual patient’s physicians.

        I am also not convinced that the “education and nutraceutical solutions” that Dr. Lynch provides are all that healthy. For some people, they may be outright harmful. I would advise those who look to this site for information to check with a licensed physician before taking any of his advice.

        Any one can claim to be a doctor on the internet. Just because Dr. Lynch has a website and does some speaking engagements, does not mean that he is qualified to dispense medical advice. If you check, you will find that the school that Dr. Lynch graduated from, Bastyr University, is accredited but NOT recommended.
        Always know who you are dealing with before you take their word on medical matters. Be healthy and safe, Daniel…and smart.

        • Dr Lynch October 1, 2013 at 12:15 am # Reply

          Jennifer –

          “As far as making a living, other researchers are paid by the medical or academic institutions for whom they work and by grant money.”

          Most of the time, one is heavily restricted by what one can research if they receive grants. Plus it takes a ton of time to write these. I’ve helped write one for a detoxification study – which actually ended up being approved by the NIH. This was years ago. Now the NIH has stripped down what the research team can and cannot do and also has pulled back on funding.

          I don’t want to deal with that.

          I just want to research.

          People can buy the lab tests here – or – as I strongly recommend – they can go to their doctor and get it covered by insurance.

          Back to preparing slides for my upcoming conference – which has – yes – over 40 MD’s attending from ‘real’ medical schools – and over 300 health professionals in total.

          I’ll email you when the DVD is ready so you can buy it for your library. In the unfortunate event that you fall very ill, it may really help you.

          • Rebecca Hill October 31, 2014 at 10:57 pm #

            Get lost Jennifer this is no place for losers who have a loser life and nothing else to do but annoy others. I am shocked and dismayed the Dr. is still paying any attention to you!

            Why do you bother responding to her? That is what she wants!

        • Kelly February 24, 2014 at 7:13 pm # Reply

          So Jennifer,
          For someone like me, who has been dealing with an autoimmune disease and been in doctor’s offices and in clinical trials since 1994, I understand the process VERY well. I know medicine. Now, more recently, my husband, who had faith in the system growing up as a child of both a doctor and a head nurse for 40 yrs. was diagnosed with Renal Cell Carcinoma at age 46 in 2010. In 2009, I was accepted into the Harvard Genome Project and had my entire genome sequenced. I learned that I was homozygous MTHFR then and compounded MTR Hetero. I learned about Dr. Lynch AND 23andme through other PGP participants at a Genome conference. After my husband’s cancer metastasized, I had my family’s 23andme health genomes done. And I am so glad I did, it was the best investment I made. I can now do my own research without having to go through the bullshit of medical doctors. He went into a clinical trial and we were finally able to unblind the study – the records show that he had evidence of metastatic tumors in July but we were not informed until April of the following year. No treatment was given until June. ALMOST A FULL YEAR LATER. My husband continues to get worse BECAUSE OF HIS PHYSICIANS and now, no one will treat him… your statement to Daniel, this”proven study methods and left the testing to the individual patient’s physicians”. Really??? Show me where there is any PROVEN study methods for RENAL CELL CARCINOMA – because there is none. The ONLY hope I have now is research that is being done that is not considered “mainstream”. And, by the way, Jennifer, UC Davis has an entire department dedicated to Nutrigenomics based on this stuff – so do your homework before you bash people, and the good doctor, publicly and look like an idiot. The USDA Pyramid is changing too
          Methylation processes and nutrigenomics is key to my Cancer research and is the only hope I have right now of saving my husbands life. So perhaps you should reread your message on this thread and ask yourself, are you really doing the world a favor or are you just being a terriby mean person?

        • christine March 13, 2014 at 4:09 pm # Reply

          Bastyr University is an excellent school. I am afraid you are mental. Anyone who spends so much time harassing and stalking a doctor is a quack herself. Get a life!

        • Laurie December 8, 2014 at 2:29 pm # Reply

          It is my experience that when QuackWatch starts slamming people it is high time to listen to the person they are slamming. The person who is being slandered is usually a very successful doctor who DOES know what they are talking about! QW slammed Dr. Mercola as well. He dispenses a lot of valuable health information. So what if he sells supplements! He sells very good quality items…which I order from the U.S. and pay more for due to the quality. I am just learning about MTHFR. I can see by the excellent information on Dr. Lynch’s site that he is brilliant and progressive. He also sacrifices a great deal of time educating others. You dupes from QuackWatch are hired by the pharmaceutical companies to try and discredit doctors who do not peddle your drugs. Get a life.

          • Dr Lynch December 9, 2014 at 4:42 am #

            Be an honor if QuackWatch started talking about my work. One word for them – meatheads and another – fearful for change.

    • Kim September 29, 2013 at 4:37 pm # Reply

      Well, I highly doubt that Dr. Ben gets kickbacks from 23andme.

      My daughter is looking desperately to find foods and supplements that our year old granddaughter can take because she is severely sensitive to corn (we have milk goats just so she can have milk from animals that aren’t fed corn because she can’t have any milk or meat from animals that have been fed corn) and also has the mthfr 677 mutation and Dr. Ben has the only children’s supplement with methylfolate that is corn free that she can find. Thank you Dr. Ben, for selling it!)

      • Dr Lynch September 29, 2013 at 5:59 pm # Reply

        Hi Kim –

        I do receive a ‘kickback’ from 23andMe. Approximately half a salad. I recommend things that I use or trust – and 23andMe is both. They tested me and my entire family. Very useful. Glad that your granddaughter can take some nutritional support from us. Best to you.

  9. Heidi September 24, 2013 at 1:54 am # Reply

    I hate that we’ve gotten side tracked with attacks and criticisms. I appreciate being able to trust and find reasonably priced options to treat MTHFR through Seeking Health. I only wish Dr Lynch could still do phone consultations!! Thank goodness he knows how to set appropriate work boundaries! If he gets burned out we’ll really be in trouble!!
    If anyone has tested with 23andme plus genetic genie can you comment on how user friendly the results were. For example, do you have enough information regarding what supplements you need to take, etc. to treat different SNP’s?
    Dr Lynch, would it be possible to ask the doc’s that are attending your conference next month if they would be willing to have their names and contact info posted? You would not be endorsing them persay, just listing them. I have found very few folks who treat MTHFR in Texas, especially Houston! Think about it ………;-)

    • Dr Lynch September 24, 2013 at 7:47 pm # Reply

      Heidi –

      I plan exactly that. I will release the names of the health professionals that attended the conference – in fact, I will also post here on MTHFR.Net. I will announce this loud and clear.

      Thank you
      Dr Lynch

  10. Hillary September 25, 2013 at 9:53 pm # Reply

    Hello Dr. Ben,

    I’m wondering if one test is better than another if one is testing to find answers to specific symptoms. I’m planning on ordering one for my husband who was diagnosed ADHD growing up. He has struggled with addiction most of his life, excessive caffeine addiction (or chronic fatigue without it), irritability, insomnia, muscle pain, and recently had a month and a half long episode of schizophrenia that completely vanished and has remained gone for about a month now. Considering these concerns I want to make sure any test I order for him is going to reveal any specific mutations related to these symptoms.

    Thank you,

  11. Ed September 28, 2013 at 4:43 am # Reply

    Could someone explain what the difference between homozygous and heterozygous means in the context of MTHFR and do the tests you are referring to automatically determine which you are?

    • Nicole October 7, 2013 at 3:38 am # Reply

      Homozygous means you have 2 defunct copies of the MTHFR gene, heterozygous means you have one. so you are only half as defunct as someone with both! yes, all labs will tell you how many mutations you have. In our family we have both homos and heteros, and we find that the homo children (1 and 6 years) need the same amount of supplements as the hetero adults. I imagine when they grow up they’ll need at least double what we do. Hope that is some guide to you.

  12. Ed September 30, 2013 at 3:15 am # Reply

    Dear Jennifer,

    Quackbusters are busted. The corporation Barrett presided over, Quackwatch, which seems to have been the recipient of mysterious funding through most of its history, is now unable provide a defense (against a lawsuit for defamation). Aside from its websites, Quackwatch now appears to be defunct.

  13. Jodi October 3, 2013 at 3:01 am # Reply

    Do you have any suggestions for mineral or micronutrient testing? I have lots of methylation pathway snps and what to get an idea about molybdenum, lithium, boron, etc. Any info would help!

    • Jodi October 3, 2013 at 3:10 am # Reply

      Nevermind. Found it.

  14. Dr Brian November 5, 2013 at 3:57 am # Reply

    I.d like to be a fly on the wall for the first training course will be held at Bastyr University, October 12 – 13, 2013
    Actually would like to sit at a table with pen and paper
    These SNP’s are not good
    what about webinaring the the course?
    (where webinaring means to offer it on the web)
    now a days traveling takes a lot out of ones practice

  15. Dr Brian December 4, 2013 at 3:00 am # Reply

    Hi Ben
    It’s 3 Dec
    How was the Oct training course.?
    re asking from my last post !!!
    what about a webinar?
    Please respond
    Thank You

    • Dr Lynch December 4, 2013 at 5:00 am # Reply

      Hi Brian –

      Sorry – missed your comment.

      There will be a full recording on a DVD set available in about a month or so. I will announce it via as a post and also Facebook and my newsletter here.

      The training course went really well – very pleased with how it went actually.

      There is a March course coming up – I will announce this later this week.

      At the moment, there is not a web stream for this event as it is just too long.

  16. j walsh December 13, 2013 at 12:15 am # Reply

    Dr Lynch,

    I was dx with homozygous c677 one year ago. I cannot find anyone to help me.. and have been repeatedy told to forget about it. none of my blood work comes back with concern other than phospho lipid battery of tests that again, isnt inspiring the docs to take action.

    i live near pittsburgh, buffalo, cleveland. have gone to cleveland clinic.

    started on methylfolate 1000mcg and methyl cobalamin along with curcumin. fish oils made me sick and I noticed such thumb joint and arm pain that i can barely type. i have to lay off all supplements until i can get some guidance. do you have any recomendations for specialists that can help me? the online specialists from some of the mthfr websites charge significantly and do not appear to be physicians. my pain is becoming more global and disabling.


    • j walsh December 13, 2013 at 12:19 am # Reply

      also just ordered the 23andme but have NO way of interpreting results.. hope you can direct me as their statement said they will not release any health related info (?)

  17. Joy December 14, 2013 at 10:02 pm # Reply

    Dr. Ben,
    You mentioned in previous comments that you would compile a list of physicians that have attended your seminar. Have you done this and if so, where can I find it? I live in Montana and would like to visit with a doctor that has a clue about all of this. Thanks.

  18. Joy December 14, 2013 at 10:19 pm # Reply

    Dr. Ben,
    I don’t have elevated Homocysteine levels, however I do have Hashimoto’s and am hypothyroid. Should I get tested for the MTHFR mutation?

  19. sulakshana December 26, 2013 at 6:52 am # Reply

    can you please help me how i can go with my sons methylation support.presently taking methyle folate,methyle B12 ,TMG,B2,zinc,magnesium.SCD deit.he is recovering from autisn.but he still has Ocd .after taking methyle folate his RDW coming back to normal from 15.7 to 14.3(normal ia 11.6 to 14)still he has borderline anemia haemoglobin 11.6.shall i go for other form of scared of his COMT herero.

    COMT V158M+/-
    COMT H62H+/-
    VDR Bsm+/-
    VDR Taq+/-
    MTHFR A1298C +/+
    MTR A2756G+/-

  20. Evin January 8, 2014 at 4:01 pm # Reply

    I just ran raw results through the MTHFR Support test you advocated for above and am disappointed. You wrote, “This report is broken down into various categories. I have provided MTHFR Support some of the findings from my research which they have added to their report.” I guess this implied to me that there would be some information from your research about why genes were included. All my report included was links to which gives very little information. So, I paid $20 for a lot of information which makes no sense to me. I *really* wanted to know why the tongue tie genes were included–tongue tie in our little one is the whole reason I started down this path…Genetic Genie at least explained why the gene was important and gave enough information I can begin some research and understanding. After reading this website and waiting two months for our 23 and me results so that I could see our little one’s tongue tie information I am really disappointed and feel misled.

    • Dr Lynch January 8, 2014 at 7:02 pm # Reply

      Evin –

      As you know, the FDA cracked down on 23andMe for providing information relating to Health Traits. When a report comes out stating what a gene polymorphism may or may not do, it is doing exactly what got 23andMe in trouble in the first place.

      Yes, we want to know exactly what these genes do but it is way more than genes.

      Please read this article on DNA Testing.

      I will write another article soon on how to research various gene polymorphisms on your own.

      Quickly, when you find a gene polymorphism on your report having the homozygous risk allele, plug in that specific rsid into Google Scholar. There you will discover various research.

  21. Michele Zimmer January 23, 2014 at 5:41 pm # Reply

    People should be aware that 23andMe has changed their testing. You can get your raw data still but it is not as complete as it once was. They changed their processing from a 59 SNP chip to a 41 SNP chip. This means they are not reporting back as many SNPs as they used to (59 vs 41). This means your data when processed by MTHFR support will not be as complete. You will be lacking the data for MTRR H595Y, BHMT-04, AHCY-02, CBS N212N, and SHMT1 C1420T. My family purchased the tests. My husband was processed on the 59 SNP chip and my son and I were processed on the 41 SNP chip. Now it is harder for my doctor to determine my son’s and my protocol since data is missing. I really don’t want to go and spend more money on testing. So buyers beware, 23andMe is NOT what is used to be (raw-data wise).

    • Carol June 16, 2014 at 3:38 pm # Reply

      Dear Michele,
      My husband and I recently received our raw data from 23andme. Once I uploaded the SNPs to Genetic Genie, our methylation analysis results came back with all of the ones you listed as ‘not there anymore.’ Please try again and see what the results are.

  22. Fran January 24, 2014 at 5:58 pm # Reply

    I followed the 23andme link. Apparently, as of Nov. 2013, this company cannot provide health related testing/reports for new customers. Heres the page I read.

    Is there an alternate place that will give multiple test results?

  23. Dr Rhonda Simons February 18, 2014 at 3:13 am # Reply

    I use HDL (Health Diagnostic Labs)labs. This is FREE for all patients who have any private insurance. It is blood testing for 677 & 1298, as well as Apo E, and advanced lipoproteins, and inflammatory molecules–hs-CRP, fibrinogen, MPO, and Lp-PLA2….I also use Singulex for other inflammatory molecules: TNF-alpha, IL-6, IL-17…ALL of that testing is FREE to patients, as they take what insurance will pay, and never remainder bill.

    I also use Genozyme/Genomind testing which uses saliva. Also FREE to patients with private insurance. Presently only the 677; however 1297 due in the fall, as well as 19 other cool genes! They also do serotonin transporters and receptors and dopamine transporters and receptors, as well as the different Cytochrome P450 pathways: C19, 2D6, etc…this lets you know if patients are metabolizing through certain pathways too slowly (increased side effects, toxicity), or too fast (gets out of system too fast so it “doesn’t work”–then some docs tend to increase dose which can be harmful.
    Okay to e-mail me at if you would like to have contact info for the reps for those labs so you can offer them.

  24. Nicole February 26, 2014 at 5:15 pm # Reply

    I’m wondering why you’re still recommending 23andme when they don’t test for MTHFR. Makes it hard to trust any of your recommendations.

    • Dr Lynch March 1, 2014 at 7:14 pm # Reply

      Nicole – 23andMe does test for MTHFR. I explain it fully how it works in this article.

  25. Larisa February 27, 2014 at 1:10 am # Reply


    Which one should I trust more blood test or saliva 23andme test?

    Im hoping to get some guidance about some conflicting genetic info Im getting. My doctor ordered a MTHFR test back in october, the results were homozygous for 1298 and normal for 677.
    I ordered a 23andme test a few weeks ago to uncover any other mutations that need to be addressed. I uploaded my results to and to sterlings app they put me at compound hetero for both 1298 and 677.

    I know you are really busy, but if you could please respond, I would really appreciate it.
    It will greatly inform my protocol, I want to be informed as possible.

    • Dr Lynch March 1, 2014 at 7:20 pm # Reply

      Larisa – need to contact the doctor and let him know. One lab is wrong and need to find out which one.

  26. terri March 13, 2014 at 10:49 am # Reply

    Since23 and me went under FDA scrutiny, does anyone have a NEW list of SNPs they test? I have a bad feeling about them but still trying to decide between Yasko & 23 and me. (Already know my mthfr &will know CBS soon…need other SNPs)

  27. Betsy Fiel March 17, 2014 at 5:35 pm # Reply

    23 and me site states “at this time we do not offer health-related genetic reports”. I assume this means to select another type of testing option, is this correct?

    • Dr Lynch March 18, 2014 at 5:36 am # Reply

      23andMe is still taking test samples – and you still can receive your raw data.

  28. Laura Foster March 24, 2014 at 5:37 pm # Reply

    Dear Dr. Lynch, after having two sons, I believe I began to have 2D6 issues and will vomit drugs in that class, and was hospitalized twice after consuming sulfites. I then had 2 years pass and suffered from acetylcholinesterase inhibition due to being sprayed in an overspray with Dursban (an organophosphate pesticide) actually “chlorpyrifos.” I became unable to tolerate any items one would call “toxins,” pesticides (including all forms) most foods, perfumes, chlorine and anything such as floor waxes made from petrochemicals. At one time I was found to be “allergic” to all but two foods. I had a genetic test prior to that and found I have a genetic predisposition for hypercoagualable blood and fibrinogin deposition. I used to take a blood thinner and some supplements to address those issues. Four years ago I was told I have cardiomyopathy following hospitalization for low sodium (followed by a seizure for which I now take clonazapam), and cardiac enzymes prompting an angiogram. My husband died 8 months ago and I am disabled and alone. I wonder if you would speak with me online or on the phone about what I should do now. I am reading the two ways to test and wonder which way to go. My relative (my cousin’s daughter on my father’s side) told me about your work. I need to be able to take care of myself and that includes being near toxic chemicals, near airplane exhaust, car exhaust, etc. Now I am an older, single woman with heart failure and detox issues. I have post-exertional fatigue and was dx with CFS at Johns Hopkins due to disautonomia in 95, so I need to get well due to having no support system in place. Most doctors have no idea what might be wrong with me, so I have been fortunate to get care at all. I live in the Dallas area and am tired of Dr. Rea’s clinic due to high costs and low/slow return on investment and continuous use of shots and detoxing in sauna. My email is above. I can be reached at 817-296-1883. I purchased the phone for a call from Dr. Lynch so any attempt from readers to misuse the phone number will be fruitless. I have an urgent need to be self-reliant. (PS Quackwatch is just a chemical industry front group). All the best, Laura Foster

  29. Loribeth March 27, 2014 at 6:19 pm # Reply

    I would love to get in touch with the Becky that posted on October 1, 2013 at 1:03 am…
    I am very interested in more info on the “8 day liquid diet cleanse from Heavenly Herbs” and cannot track down a company by that name with a product like that. If you read this will you please post a URL or phone number or even the city, state, country of the Heavenly Herbs company that you used. Thanks in advance!

    • truly May 22, 2014 at 11:42 pm # Reply

      I would like to know that too!

  30. Angie April 11, 2014 at 10:07 pm # Reply


    I am new to this all and desparate for answers. I am one complex case here or at least i feel. Hope this is not too long so here goes! My diagnoses in my life include Major Depressive D/O which is treatment resistant, Binge Eating Disorder, Sleep Eating Disorder from which I sleep walk and eat in my sleep, IBS, Asthma, Vaginismus or Vulvodynia. I have tried A LOT of antidepressants and I am historically either very sensitive or they do not work after a trial. I have two sisters with whom this is also the case. Well I have recently tried taking Deplin and have experienced some good and bad side effects. My mood is like night and day. I know this is not the placebo effect as I have had two trials of Deplin from which had the same mental effect. the not so good effects are feeling like a zombie, stomach turning with no mental anxiety, feeling fatigued, difficulty waking up, eyes have been effected. I have quarted the dose of the 7.5mg of Deplin and the side effects have not gone away. I don’t know what to do. I do not want to be depressed but I do not want these physical side effects. It is such a tug of war. Another thing is that the Deplin at the 7.5mg dosage was helping me sleep through the night which is a very very rare thing for me. Another thing is that I am on 12.5mg of Topamax. don’t know whether to stop the Topamax and see how the Deplin reacts at a quartered dose or not. I feel so lost and like I am in a tug of war. I am having aches and pains too. However I recently last week got out of the hosptial for Pancreatitis as well so some of it could be that too. I feel like I am definitely onto somethign but do not know who to turn to as many docs have no idea what is going on with me. Any suggestions here! Sorry for the long paragraph. BTW I have also recently quit my job due to my depression and stress so I am very committed to getting mentally and emotionally stable. Thank you!

    • Terri April 12, 2014 at 5:00 am # Reply

      Did you have your genes tested through 23 and me? MTHFR morphisms are linked to depression and so is COMT.

    • Kelly April 12, 2014 at 3:57 pm # Reply

      Angie, I’m no expert but also have suffered many strange disorders including autoimmune with very complex symptoms and now am very versed in genetics as I’m also one of the lucky ones completely sequenced in the Harvard Personal Genome Project. I also did my exome and ran my whole family through 23andme, then ran everyone’s raw data through applications like “Genetic Genie”, “Nutrihacker” and “Sterling’s App” so I could see where the methylation pathways were causing or could potentially cause disease symptoms. In the end, this is what really matters. My husband has been battling Renal Cell Carcinoma for almost 5 years now and in all this time, we’ve now discovered the symptoms are really about methylation and nutrition. If your body can not breakdown the foods into the nutrition correctly, its going to create disease pathways rather than nutritive healthy ones like normal people… we have discovered this by taking the Q96 supplement that is methylated and nano-particled to penetrate the blood-brain barrier (documentary on Discovery Health explains), bypassing the genetic mutation pathways. Dr. Amy Yasko talks about this in her books. If you have mutated genes, say like MTHFR or MTRR for folate pathways, you will not methylate folate correctly which will screw up B12 and snowball other things… homocysteine levels, etc. I have folate metabolism pathways, estrogen pathways (do not take ANY birth control or hormones if you have mutated genes here!!)… anyway, the bottom line is an easy solution may be to try this particular supplement as it has already scientifically addressed all of these nutritive pathways. You can’t go wrong. Good luck dear, I know it sucks… Also, one question as I’m also on Topamax too (it is the only prescription drug I still take, why are on on such a strange dose? I take 200mg for migraine prevention and joint pain)? Feel free to message me privately if you’d like to talk more.

      • Angie April 19, 2014 at 5:59 pm # Reply

        Hey Kelly:

        I would love to message you but I am so not computer savvy. HA

        Thank you for your email! I would love to correspond. In answer to your question, I am on low dose right now because I have a HUGE sensitivity to meds. Some landed me in the hospital, some the side effects were too great, etc etc. What I noticed about the Deplin although physically felt terrible mentally was like night and day. So I feel that I am on to something. The main thing is my sleep in which I sleep walk and eat and have little to no memory of it. It is so depressing! I am on birth control though. I have been on it for quite some time like a year or more. Well I went off of it and noticed that I felt horrible when I was off it and when I was back on it I felt much much better. So I am really looking into this 23andme stuff. Looks like it is worth it? I have spent so much money in figuring out stuff thus far. Have you found that your symptoms or your husband’s have gone away or significantly decreased since starting a correct supplementation regimen? Your email helps immensely because I know I am not alone in suffering. :)

      • Chrissa June 2, 2014 at 7:21 pm # Reply

        Hi Kelly,
        I just read a response you wrote to Angie on April 12th, 2014 where you suggested she might contact you privately. How does one do this? I would love to contact you as I have Addison’s disease and my son has Hashimoto’s! We both have all kinds of other nonsense going on too and just recently my younger sister tested homozygous for 677T – I have yet to be tested but have always been more symptomatic then her and so I’m sure it will be yet another issue to deal with. Currently my biggest problem has been an inability to absorb calcium & magnesium & I feel like I am shriveling up from the lack of moisture. Actually the malabsorbtion of Calcium & Magnesium is a symptom of my inability to produce adequate potassium & salt… So do you think Yasko tests more thoroughly? Can you tell me more about the Q96 supplement & where to get it? Thx

    • Karen von Merveldt-Guevara April 13, 2014 at 4:43 am # Reply

      Hello Angie,
      the symptoms you describe tie entirely in with high oxalate levels in your body. As you and both your sisters have the same symptoms you may share a genetic hyperoxaluria. To verify you should look into an Organic Acid Test in urine as available by Great Plains Lab – I will copy/paste a few links in here:
      …when you google low oxalate diet, you will come across several websites with recommendations… in addition there are parts of Klinghardt’s protocol in cooperation with Catherine Tamaro, who promote the use of K2-MK 4 (Menatetrenone) with Phosphorous to help reduce the effects of oxalates on the body (though there is controversy of how exactly K2 is doing its job). Out of my practice I can only say: “It works!” …the K2 protocol is on Page 44 – Good Luck! BTW I am a European MD who works in Alternative Healthcare (Integrated Bodywork combined with Orthomolecular Medicine in AZ)

  31. suzanne May 9, 2014 at 5:24 am # Reply

    Heidi, I am in houston too, tested positive January 2014 at specracell labs thru a MTHFR knowlegable naturalpath, I am heterozygous C677T & A1298C. I no longer have an MD or prospect I would trust to have faith in and do not know of any MDs who may know much about this. my naturalpathic dr suits me just fine. My April bloodwork has improved since Dec. By taking some simple supplements and diet adjustment. Would be interested to hear your Houston care experience. -Suzanne

  32. Dr. Shabnam Das Kar June 9, 2014 at 2:26 pm # Reply

    Thank you for all your input. I got your ref from the Thyroid Summit. Is testing for MTHFR rs 1801133 valid? I found a company which does only that & not A 1298C & C 677T. What is the difference?

  33. Florence June 16, 2014 at 5:52 pm # Reply

    Does the ’23 and Me’ test show the HLA-DQ2 and the HLA-DQ8 for celiac? I so enjoyed the web class with you on thyroid. Not being a doctor, have heard of methylation, however was never sure what it actually did. So much clearer now. Thank you for a reply.

    • JJ August 23, 2014 at 11:29 pm # Reply

      23andMe results include several SNPs that might predispose one to developing celiac. For example, rs2187668 (HLA-DQA1). I happen to have an A here, so I have this tendency, and have developed an autoimmune condition. I am doing much better on a gluten free/casein free diet.

      Promethease is another service that will analyze your raw 23andMe results although it is not for the faint of heart. Once you have uploaded your raw data and downloaded your HTML report, you can open it locally in your browser, click Show Everything, then do a find on a particular SNP like rs2187668. I would recommend not looking for a gene, as you may not find it in the text of this report.

      For the brave, you can also open your raw data file in any notepad-style editor and do a find that way, but you will need to do further online research via SNPedia or other sources to determine whether your particular alleles are significant.

      There are several SNPs listed for celiac in the SNPedia article:

      Livewello is another service similar to Genetic Genie, it lists many more genes related to methylation, detox, mitochondrial function, etc. but gives very little explanation. However this is how I found that I am heterozygous for both SLC19a1 and FOLR2 on Dr Ben’s Pathway Planner chart, which means I don’t process folic acid very well at all, and need to stay away from it. Dr Yasko’s supplements all contain folic acid (the synthetic form of folate), Dr Ben’s don’t (thank you Dr Ben!).

  34. Toco3 July 17, 2014 at 7:59 pm # Reply

    It saddens me to read about this ‘Jennifer’. A person who is rude and ignorant, we all should just walk away. Please do not ‘stand there’ and answer every ignorant question/accusation she has.

  35. Bobette Kyle August 14, 2014 at 3:05 pm # Reply

    FYI, 23andme seems to be caught up right now (August, 2014). I sent in kits for my daughter, grandson, and me. Daughter’s was done in less than two weeks. Grandson’s and mine will be complete in the next day or so, around three weeks total.

  36. james August 16, 2014 at 1:43 am # Reply

    Makes you wonder about these tests….

  37. Sandie August 26, 2014 at 9:30 pm # Reply

    I was just tested for what my doctor said are the two most common mutations of MTHFR. I’m confused, and honestly disappointed because I fit the profile. My daughter has a tongue tie, lip tie, and sacral dimple. I have a tongue tie, thyroid issues, chronic digestive issues (food allergies, heavy metals), and some other conditions listed. I have these issues despite doing all that I can to stay away from toxins and live a very healthy lifestyle.

    Do I need a more comprehensive MTHFR test to rule it out? If so, which one? Or should I move on to looking for another cause to my problems?

    • Sandie August 26, 2014 at 9:40 pm # Reply

      Oops. My post wasn’t 100% clear– I tested negative for the two most common MTHFR mutations.

      • Sylvia November 18, 2014 at 6:19 am # Reply

        Get a hard copy of your results. My doctor’s office called and said I was “fine” too. At my nutritionists request, I got a copy of my results. Turns out I am compound heterozygous for MTHFR. I will start treatment as soon as my 23andme results come in. If I hadn’t pursued it, I would still be in the dark.

  38. Kris August 28, 2014 at 6:41 pm # Reply

    Hi Dr. Lynch!
    I was recently tested through Health Diagnostic Laboratory and came up as Intermediate Risk for MTHFR 677 & MTHFR 1298, does that mean I actually have both genes? I am having trouble understanding the results, its seems there are 3 categories, high risk, intermediate risk and optimal. For 677 I came up as C/T and for 1298 I came up as A/C.

    Not sure if you are familiar with that lab.

    The doctor that ordered the labs has been treating me for Lyme Disease. He advised me to take L-Methyl sublingual B12, 1000mg. Would you agree with him?

  39. Chaim Bochner September 18, 2014 at 9:20 pm # Reply

    Hi Dr. Lynch,

    I ordered the 23andme, took the test, and after step 3 I get the message:

    Chaim, unfortunately we weren’t able to analyze your sample. There are no known steps that will increase your likelihood of receiving results from an additional analysis attempt. Find out more here.

    What are the chances of getting the second test processed? Also, it took me longer than half hour to collect saliva, is this maybe the reason for failure?

    I’m very concerned because I need to know the additional genetic mutations I might have.

    Please advise.

    Thank You,

    Chaim Bochner

  40. Karen Marciniak October 15, 2014 at 2:27 pm # Reply

    I have been searching for alternative healthcare recently myself. Why? Because I have been prescribed several medications had multiple surgeries and I would rather find the root cause and prevent rather than treat health issues. My question is: Why don’t Medical Doctors suggest genetic testing when there are multiple disorders and common family health issues? I unfortunately think I know the answer to that. I will be tested this week for MTHFR. One of my adult children tested positive for it. We have had multiple cancer diagnosis in our family, many fatal. Personally I have had Peritonsillar abscess (tonsillectomy), extreme diverticulitis (colon resection of 8 inches), hypertension, constipation, gerd (taking omeprazole), repeat infections; respiratory and ear, now diagnosed with gallstones I have also had hernia surgery from all of the surgeries as I have had 9 surgeries thus far. ALSO I once had a chiropractor tell me after looking at xrays that I have evidence of Spinal Bifida.
    I am so sincerely thankful for my daughter who researched this for the sake of family and self and also so sincerely thankful to Dr. Lynch for his public service and caring attitude. He deserves to profit from it of course. I have shared MTHFR information with my faith based LinkedIn Group. There are over 4,000 members many of whom are medical and nutritional professionals. This is how I am trying to help get the word out.

    • Angie October 15, 2014 at 2:39 pm # Reply

      A to the men Katen!!! It is really cost effective to get this testing done and costs less than the repeated meds they push out that don’t work. I feel ya!!

  41. Kath Platt October 16, 2014 at 9:11 pm # Reply

    October 16th 2014 Rochdale Lancashire, England. Dear Dr. Ben Lynch My nutritionist suspects a methylation problem, can I be tested in England or send away for a test to America? I would chose the 23andMeTest. I eagerly await your response Thanks Kath.

  42. Pam October 25, 2014 at 8:02 am # Reply

    I received my 23andme results. Who do I go to in Denver, Colorado to interpret and give me the proper protocol of supplements I need to get well?’

  43. Jen November 8, 2014 at 1:12 am # Reply

    Can any of these tests be done on infants/babies?

  44. Mary D November 20, 2014 at 4:05 pm # Reply

    Becky, please contact me. I need to do the colon cleanse your daughter did.

  45. Cyd December 5, 2014 at 8:54 am # Reply

    I am all about information and taking charge of ones health. However, I would suggest those looking at 23andme look deeper into this company. The data mining on the Internet is great. Google is king of it and this company is the Google of your DNA data. The CEO also happens to be in the Google family. Here is just one article of many to be found on the net. Be informed, but be careful. Your DNA is very valuable information.

    Just so you know, I was tempted to do this test. Just found out my child is Mthfr positive and struggles in many areas. So my interest is genuine.

    Good luck to all in your search.

  46. Stephanie December 12, 2014 at 2:16 am # Reply

    Hi Dr.Lynch ,
    I just ordered 23& me for me & my children . I have a son with autism . I am 34 , newly diagnosed with two mutations of c1667. I am trying to research all I can , I’m very sick, I need a good Dr to help . When will you be doing conferences in Vegas again? I told my primary Dr , I would pay him to go to your conference ! I was on methyl- guard & made me too tired. That is the only way he knows to treat MTHFR. Please come here soon ! Or reccomended a Dr out here in Las Vegas, Nevada for me to see ? PLEASE
    Thank you !

    • Dr Lynch December 12, 2014 at 6:21 am # Reply

      Hi Stephanie –

      Please inform your doctor about these online training courses – will help him immensely – and you.

      Here are a list of doctors – expanding all the time.

    • Amanda March 21, 2015 at 2:05 am # Reply

      Stephanie, have you found a doc in Las Vegas yet? I am also ooking for one knowledgeable in LV.

  47. Jana R January 10, 2015 at 6:15 am # Reply

    Hi Dr Lynch

    Do you know what might happen if an adult with a history of sulfite/sulfa/histamine sensitivities took 5-MTHF plus Calcium Folinate if they don’t actually have the MTHFR gene and were incorrectly diagnosed?

    Don’t mean to put you on the spot and realize everyone is different, but generally speaking, what are the chances of a negative reaction? Thanks – Jana

  48. JJ January 13, 2015 at 1:19 pm # Reply

    Jana, this thread is about getting tested for MTHFR…

  49. Jana R January 13, 2015 at 3:45 pm # Reply

    Ooops… sorry… didn’t read all of the posts and assumed it was ‘general’, not specific to any one topic… didn’t mean to derail the Thread — was not my intention.

    I don’t have the money or insurance coverage or support system to help me to get the test done. But am positive I have the MTHFR gene. I thought maybe if I just take the supplements and feel better after a few weeks on them, then there’s my answer.

    No need to reply. People do out of character things when they are desperate in pain and need answers. I’ll look for the appropriate Thread and copy & paste this post on there.

    Thanks… no need to reply here. It will disrupt the flow of the Thread. Jana

  50. Ms W January 14, 2015 at 9:55 am # Reply

    I’d LOVE to do this and would like my information to be as through as possible. However 23andMe has removed following SNPs:
    MTRR H595Y (rs10380)
    MTRR R415T (rs2287780)
    BHMT-04 (rs617219)
    AHCY-02 (rs819134)
    CBS N212N (rs2298758)
    SHMT1 C1420T (rs1979277) so it’s clearly not as informative as it was. What I’d like to know is which dna tester provides the most thorough snp information.


  51. JJ January 15, 2015 at 3:13 pm # Reply

    Genetic Genie only accepts 23andme raw data. You will get the most value from them. It’s not necessarily about testing the most SNPs, it’s about which SNPs have been researched and are actionable.

    This question was answered when 23andme changed to their V4 chip; Google is your friend.

  52. Vicki January 24, 2015 at 10:58 pm # Reply

    Dr. Ben,

    I’m not sure if you remember me (back when you used to consult), you helped me with my son Jackson. He had lots of gut issues which we have finally mostly healed. (It has taken YEARS) He still suffers from fatigue, exhaustion, loss of energy, PANS etc… because we have not figured out how to successfully supplement yet. Can’t tolerate Epsom Salts and takes D-Hist for allergies and I’m afraid that is wrong. Sometimes does well on fish oil and sometimes not. Very confusing!!! I’m hoping you or someone can help me make sense of his 23andMe results:
    ene & Variation rsID Alleles Result
    COMT V158M rs4680 AA +/+
    COMT H62H rs4633 TT +/+
    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 CT +/-
    VDR Taq rs731236 AG +/-
    MAO A R297R rs6323 T +/+
    ACAT1-02 rs3741049 AG +/-
    MTHFR C677T rs1801133 GG -/-
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 GT +/-
    MTR A2756G rs1805087 AG +/-
    MTRR A66G rs1801394 GG +/+
    MTRR H595Y not found n/a n/a
    MTRR K350A rs162036 AA -/-
    MTRR R415T not found n/a n/a
    MTRR A664A rs1802059 AG +/-
    BHMT-02 rs567754 TT +/+
    BHMT-04 not found n/a n/a
    BHMT-08 rs651852 TT +/+
    AHCY-01 rs819147 TT -/-
    AHCY-02 not found n/a n/a
    AHCY-19 rs819171 TT -/-
    CBS C699T rs234706 AA +/+
    CBS A360A rs1801181 GG -/-
    CBS N212N not found n/a n/a
    SHMT1 C1420T

    I want to help him. He’s better, but not his best.

  53. Dominick January 26, 2015 at 1:55 pm # Reply

    Hi Dr Ben,

    I am a UK trained osteopath practitioner working in Ottawa with a strong interest in Functional Medicine. I am been recently learning a lot about MTHFR through your website. I am interested in beginning testing firstly for my family, like to try things first and then my clients. I recently came across a report on 23and me in the Canadian Press and wondered if you had any comments?

    Kind regards


  54. Maxine January 30, 2015 at 7:24 pm # Reply

    Hello DrLynch. First I want to thank you for all your informative information and research. I have a question regarding getting the genetic testing done. I am in a nightmare with medical issues, chronically ill, and Drs which seem to care less of any of my symtoms, or actually Diagnoise’s I have. I talked my PCP into doing a Clotting test for me. He is a Internist, (new dr in a small town and they all seemed to be overwhelmed and no time for patients) Ok I have heart issues, many other illness’s. A long list. Hashimotos, Fibro, osteoporosis, Ashtma, arthritis, Sinus issues and recently diagnoised with CF. Ok on the blood work, one came back positive, High. This is what lead me on the search and found you. I have homocyst(e)ine, Plasma at 15.4. Reading about this and I am a woman, Seems that is considered High period. I have been concerned with Heart issues, Prior MI. Valve leaks, CAD, Diastolic dysfunction, a eco back in 2011 show cardiomyopathy with stenosis, and Arterial right and left enlargement. I was not told any of this and as far as my care goes, I just keep getting the blow off. I have abnormal EKCs.. I have a pace maker. Hole in heart , called this a PFO, but it is a left to right shunt. Has me very concerned with all the recent chest pains putting me in the er, and what I have read, a PFO is only a right to left shunt, and a ASD would be left to right. With the diastolic dysfunction, I am so concerned about PH. and recently, was released from ER with a 75% probably PE!! I have suspected I have some kind of clotting factor going on. I was diagnosed yrs ago with the first episodes of Chest pains, with presmetal angina. Now these Drs just over look that. I am so frustrated beyond what words can even say. I have spasms it seems every where. Stomach, bowels, esophagus, and In the artery for ABG, was told that. A angio confirmed spasms! I am on no heart therapy at all. Just dismissed. Now getting back to this gene and figuring out , how I can get this Dr to test further for the genes, because it seems to be a cardiac marker for all the problems I have had. Like a piece of the puzzle. All I got from the nurse was a email on my results, stating this test was a little elevated and the Dr said it is a VIT B 6 issue? that was it and wants to check my VIT B. Nothing said about I am at high risk and it is a Cardiac Marker. I also did a kit with the 23&me for the IBD study. So I do understand the test will have Raw data, correct? So will this help me in trying to find out if I have a genetic mutation or not? How can I proceed to try and get this Dr to do the genetic test, and then from there any info for someone like me dealing with heart problems and continued chest pains. Thanks

    • framistat January 31, 2015 at 8:46 pm # Reply

      Maxine, you say you had a test done with 23andme. Do you have your password to the website? You can login and download your raw data and save it on your computer. Then go to the website, upload your data, it’s $5 for a comprehensive report. You probably won’t understand much of it, you will need help interpreting it. You don’t need a doctor to get the report, you do it yourself.

      • Maxine February 2, 2015 at 2:05 am # Reply

        Hi. Hope this goes to the person who replied to me. I joined the IBD study, Through the me&123. I Know they are not doing health anymore. But The test I understand, you get your genetics and RAW data. Yes I have my password, Just have not got back any reports as of yet. I am confused though, with the 123 not providing any health genetic info at this time, exactly what I will get back, and can I down load that data? Can’t do anything until the test comes back though. take about 4 more weeks. Thanks (who can I get to help me to interpret the test??

      • Maxine February 19, 2015 at 12:37 am # Reply

        thanks so much for the info . I am having so much trouble with all of this. I just posted my results from one of the sites here. Hoping for some help. I will go to the other site you gave me also. Appreciate it. Also having trouble here, trying to find the post after I already posted it!

  55. Carol February 3, 2015 at 11:54 pm # Reply

    This is what the website, 23andme says about their MTHFR test:

    We no longer offer our health-related genetic reports to new customers to comply with the U.S. Food and Drug Administration’s directive to discontinue new consumer access during our regulatory review process.

  56. framistat February 4, 2015 at 3:21 pm # Reply

    If you READ this article – you still have access to your raw data – you download that, then upload it to other sites like Genetic Genie or Promethease, which analyze it and produce a report.

  57. Fred C February 12, 2015 at 10:38 pm # Reply

    If you read 23andMe site they are updating all the time. I just had report done then went to MTHFRSuppourt and downloaded data for a FORTY TWO PAGE REPORT!!!!!!! After reading older replies I say “what do you want?” Cost is $30. There are 114 different SNP’s under Methylation & Methionine/Homocysteine Pathway with 11 MTHFR markers!! To all: I would reload data. FMC

  58. Maxine February 19, 2015 at 12:31 am # Reply

    Ben, I have the raw data from the 123 site. I submitted it to the one site, the MTHFR site is having trouble right now from what I gather. What is the Detox DNA? Who can help with this? Can I upoad this here also> I am very sick and with little answers. to be as short as I can be, I am not getting much answers in the medical field and just being blown off basically. I have heart issues and have been concerned of a clotting factor. Talked the Dr into doing a clotting test and the homocyst(e)ine, plasma came out at 15.4. I am a woman 59. I read quite a bit about this and seems that is very high for a woman. which lead me into looking into the MTHFR and you. I have Heart issues, chest pain, constant now, afraid I may have a clotting disorder. ER ambulance rides, 5 last yr . High d-dimmer along with a 75% probably PE, by ventilation perfusion scan. Clots run in my family. I am being ignored by the medical community. This last test, the Dr just stated I might need Vit b6. Not concerned about the heart issues related. I have a pace maker, deal with chest pains and tightness daily. Living on nitro most daily. Have fibromylisia, CFS, Chronic Dyspnea, SOB, very fatigued among a bunch of other health problems. tested Positive also for CF, still getting the run around on this! This is why I am so interested in genetics and where I live, seems no Dr are. A not so good place for medical care. I am listing my info on the data I received from the one site. In input or help , or anyone Gene & Variation rsID Alleles Result COMT V158M rs4680 AA +/+ COMT H62H rs4633 TT +/+ COMT P199P rs769224 GG -/VDR Bsm rs1544410 CC -/VDR Taq rs731236 AA +/+ MAO-A R297R rs6323 GT +/ACAT1-02 rs3741049 GG -/MTHFR C677T rs1801133 GG -/MTHFR 03 P39P rs2066470 GG -/MTHFR A1298C rs1801131 GG +/+ MTR A2756G rs1805087 AA -/MTRR A66G rs1801394 GG +/+ MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/MTRR R415T rs2287780 __ no call MTRR A664A rs1802059 AA +/+ BHMT-02 rs567754 CC -/BHMT-04 rs617219 __ no call BHMT-08 rs651852 CT +/AHCY-01 rs819147 TT -/AHCY-02 rs819134 __ no call AHCY-19 rs819171 TT -/CBS C699T rs234706 AG +/CBS A360A rs1801181 AG +/CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call
    Name: Maxine Simon Profile: Methylation Profile Generated: 2/18/2015
    Methylation Profile generated by Page: 1which can help would be very much appreciated.
    This is what it says about all this:
    You have homozygous (red) mutation(s). These are the worst type of mutations. They include:
    MTHFR A1298C
    MTHFR A1298C

    Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR):
    Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):
    MAO-A R297R BHMT-08 CBS C699T CBS A360A

    • Fred C February 19, 2015 at 5:47 pm # Reply

      hey Maxine: I would wait for MTHFRSupport to update as they have a great product. What is your Vit. D level? Resent MAJOR studies showed 90% of type 2 diabetics had low D and low D was associated with heart attack, stroke, arteriosclerosis, and sudden death syndrome!!!!!!! I have read levels over 50 with 1 comment stating 80. My D has been low all my life and when I got it over low limit my lipid pnl was lower then ever!!! Use D3 which is cheap. Dr Lynch has a good product. Also don’t forget to talk with you Dr!!!! Note: I talked to mind and stated “everybody has low D” My comment “maybe that is why heart disease is USA #1 killer” Good luck.

      • Maxine February 19, 2015 at 6:42 pm # Reply

        Thanks for the info. My Vit D has been low in the past. I take the D3 daily. Don’t know where it is at now, but they have said it is fine in this last yr. (I am fighting care where I live and do not want to even get into this) I am on my own, doing my own research, trying to figure out myself. Any good Drs I have are out of this area. Other then that, Forget getting any help. I also wanted to know, which seems weird with the DNA results I have, Does that mean I have a Double MTHFR A 1298C? I wonder then why my Homocyst(E)ine level was high? 15.4 Not only is this a gen they seem to Ignore , like the Dr says, but also I don’t understand why my Levels are high (which by the way , my dr has no concern about it anyways, ) I am so frustrated and have to many things wrong with me, to try and figure this out!! You know when you are dealing with a multitude of health issues, One med for one disease, may be horrible for something else you have!!! Same as vitamins , how you eat, etc etc.. I need First to know what I have and what is off in my body?? Second I need a nutritionist, and a good PCP which will put this whole puzzle together and help me!! I just am so frustrated right now.

  59. framistat February 19, 2015 at 7:22 pm # Reply

    Most allopathic doctors know very little about nutrition, MTHFR, how to test or how to treat with drugs rather than supplements. If you continue to look for this kind of care from that kind of doctor, you will continue to be frustrated.

    I suggest you look for a functional medicine practitioner, perhaps one trained by Dr Lynch, and take your results to them. If finances are tight, ask them to arrange as much testing as possible in a way that your insurance will pay for it, and get an estimate up front for how much they think your treatment will cost over whatever timeframe they are considering. By the way, MTHFRSupport is offering their report for only $10 until the end of the month… usual price is $30. I have no affiliation.

    I also suggest you start getting copies of your records from any tests or doctor visits. You can request them for past tests and visits as well. You may have to sign a form, you may have to pay a small fee, you may have to be persistent, but you can get them. It would be helpful to have these when you go to a new doctor of any stripe. It will also help you to understand your conditions, for example, you should know what your vitamin D level is. If you had a copy of your lab report, you would know.

    Knowledge is power. Go for it. But go to the right places, and nurture a positive attitude.

    Be sure to click around on this site, find Dr Lynch’s videos, watch them, listen to his podcasts, find other places where he is interviewed and listen to those, too. You should be able to answer your own question about your homocysteine level after you’ve done this.

    Best of luck to you.

  60. nicole February 20, 2015 at 6:27 pm # Reply

    Hi Dr. Ben, thank you for all the great information! The pediatric geneticist at Albany Med is willing to run further testing on my daughter, who is homozygous for C667T, but we’re not sure which test to run. What SNPs should we be looking for in terms of methylation pathways? Also, my daughter has crazy full body itching to the point where she has had trouble making it to school for the past 3 years. Are there histamine related genetic SNPs we should look for?

    Thanks so much!

    – Nicole

    • Dr Lynch March 2, 2015 at 7:59 am # Reply

      Nicole –

      Sorry to hear about your daughter.

      Foods are a common cause of full body itching.

      The slowed MTHFR enzyme, along with slowed methylation, also may contribute to higher histamine levels. You can check her histamine levels and see how they are doing.

      If she is not eating enough methionine, that may cause increased itching – and methionine comes from protein.

      I am not sure of your daughter’s age but I know that Methionine has helped some people in the past quite well with itching – however – again – it is only one possibility out of many others.

  61. Karen March 21, 2015 at 2:30 pm # Reply

    Do both brothers have to take the 23andMe test if they have the same mother and father ? Would the results be different? I suppose they would be.


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