Read this First!

Welcome to MTHFR.Net.

You are here at MTHFR.Net because you are in need of help or someone is.

You’re in the right place. Truly.

Dr Ben Lynch, me, is very passionate about getting MTHFR into the media and increasing awareness of this very serious gene mutation.

If your doctor or loved ones are not taking you seriously on your MTHFR mutation, I am.

Let me say one thing and hear me clearly:

Knowing if you or a loved one has the MTHFR mutation is a blessing. It is not bad news. It is very positive.


Because knowing you have it means you can do something about it!

Let’s get to doing something about it.

In order to get the most out of MTHFR.Net, please do two things first:

  1. Share Your Story on MTHFR.Netย – contribute and share your story. In order to increase awareness of MTHFR mutations, we need to demonstrate that many are in need of support with MTHFR and the seriousness of it. The more you share, the better. You will not be judged here – only supported. Please do share your support for others as well by commenting.
  2. Take the MTHFR Survey – provide specifics for Dr Lynch. Again, the more information you provide, the better Dr Lynch can serve you.

Now that you’ve shared your MTHFR story and have taken the survey (Thank you! ๐Ÿ™‚ ), let’s provide some information for you on MTHFR in guided fashion.

Here are articles I’ve written which you should read in order from #1 on down.

  1. What is MTHFR?
  2. Conditions Relating to MTHFR Mutations
  3. Screening for MTHFR (most relevant to health professionals)
  4. MTHFR Testing
  5. Additional Lab Testing to Identify Imbalances
  6. Methylfolate: Taking Too Much a Problem?
  7. Methylfolate Side Effects
  8. MTHFR C677T Mutations: General Protocol
  9. Prenatal Supplementation with MTHFR
  10. Normal Levels of Homocysteine and MTHFR
  11. Questions about the MTHFR mutation? Ask Here.
  12. Find a Doctor who may know about MTHFR

Continue to check back often as I am continually updating MTHFR.Net with more resources and information.

Want to dig into the research? Visit the MTHFR Research page which is continually updated

Expand Your Knowledge in Health: View Recommended Books and DVD’s

Be sure to LIKE my Facebook page as I interact often there.

Be sure to sign up to receive my free newsletter on MTHFR issues. I do not spam. Ever.

Look forward to getting MTHFR on the map and helping you get the information you need – and the health you deserve.


72 Responses to “Read this First!”

  1. Joanna January 29, 2014 at 3:15 am #

    I’m scheduled to see my endocrinologist on April 29 and was wondering if MTHFR is something that I should discuss with him as do not currently have a physician that monitors it. I see the Endo due to low vit d, and an issue with my parathyroid (it robs calcium from my bones) so i take potassium and calcium to balance things out. If I don’t take the potassium and calcium i have sever bone pain. I have two mutations that i know of A1298C and C677T. My Endocrinologist is also trying to help me get control of my weight as this has been a struggle for me since my hysterectomy. I have went from being 125 lbs up to 213 lbs over the last 12 years and can’t seem to get it under control. I’ve gained 10lbs just since the beginning of the year! ๐Ÿ™

    • Sam December 16, 2014 at 10:52 pm #

      Hi Joanne
      I have exact same mutations and symptoms as you. Bone pain is the worst! I am wondering what makes you take potassium and how much? Also calcium? Did someone tell you it is helpful? Thank you for response! I am going crazy trying to figure out what is triggering the bone pain….worse on certain days.

      • Cathy February 7, 2015 at 4:03 am #

        Hi, have either of you been checked for a parathyroid tumor? I had one and got a second opinion because the first endocrinologist thought my “numbers” weren’t bad enough :(. The bone pain you both mentioned was horrible! As I mentioned, my second opinion doc took it seriously. Since the tumor was removed, it has been amazing. Still have muscle and joint problems, but that bone pain is all but gone. Just wanted to mention my experience so perhaps you might have some hope, or at least a possible direction you could go. Good luck!

  2. Jessie January 30, 2014 at 2:33 pm #

    My son is compound heterozygous. He takes zinc and magnesium, and I’ve just introduced B6. When he takes B6, he seems to overmethylate (i.e., he acts the same way he did on Deplin, b12, hydroxy b12, and 5MTHF ). HIs integrative doc wants him on B6 to help with the magnesium, and he wants me to start L-thiamine. Any tips on why he can’t tolerate B6 and whether I’ll see a similar rejection with L-thiamine?

    Thank you!

  3. simone January 31, 2014 at 3:14 am #

    Hi there,
    Just had a thought regarding miscarriage and links with MTHFR. I understand that low active methylated folate can lead to low cellular division which is needed for an egg to develop properly and it also needed for DNA to RNA replication in the cells – this could be a factor in recurrent miscarriage along with the higher risk of chromosomal/neural defects. However, I also thought that a low production of nitrous oxide would also affect circulation to the uterus possibly causing thin uterine lining, which can also affect implantation of an egg. This may be causing a triple whammy detrimental affect on pregnancy (along with any clotting issues – a quadruple whammy !). I know that taking higher doses of Arginine can increase the uterine lining (by production of nitrous oxide), so I wonder if bypassing the MTHFR defect pathway, women’s uterine linings may improve in oxygenated blood and also the amount/quality of lining? It would make sense also because most losses are very early which may mean the eggs are not successfully fully implanting. I personally have a thin lining and have done so for the past few years (not knowing I had the homozygous C677T defect) and have noticed improvement since taking the methylated folate and B12.

    What do you think about this theory Dr Lynch?

  4. Louise June 15, 2014 at 9:36 pm #

    Your survey does not work – the part which asks reasons to be tested I clicked on that to put fatigue as number 1 and it assigns numbers 1-17 in order down the page and I am unable to edit. I really want to help and do the survey, but this is very frustrating.

  5. Linda Mason August 11, 2014 at 5:29 am #

    I have not had a test for MTHFR. I can ask my doctor but he will probably say no. It will be hard for me to spend 150 for it since I live on social security. My question is. I have normal folic acid on blood work. Would I have low folic acid if I had MTHFR? I have low b-12, low D, Rhumetoid arthritis, my low be is from Pernicious anemia. I have inner ear problem where i have lost all balance function they think from a viral thing but have been told numerous reasons. I a

  6. Linda Mason August 11, 2014 at 5:39 am #

    I have not had a test for MTHFR. I can ask my doctor but he will probably say no. It will be hard for me to spend 150 for it since I live on social security. My question is. I have normal folic acid on blood work. Would I have low folic acid if I had MTHFR? I have low b-12, low D, Rhumetoid arthritis, my low be is from Pernicious anemia. I have inner ear problem where i have lost all balance function they think from a viral thing but have been told numerous reasons. I had a genetic test for celiac disease and showed I had 2 genetic things but on blood test for celiac through my doctor said no antibodies. I had 1 miscarriage in 1982 then my 1st son was born 6 week early and my second son I started bleeding around 4 month pregnant and on bed rest for the rest of pregnancy couldn’t get out of bed except to shower and go to bathroom. He was full term basically about 3 weeks early. I have all over body pain and have been to emergency room for pain from sciatica and my bowels constricting with pain. Have been told it probably from arthritis. One thing that is very difficult is my vision. I just lose my vision in that I will start seeing double like the muscles in my eyes stop functioning. But am told it from the inner ear problem. I use to have migraines all the time but not so much in my older age. I am curious if having normal folic acid in common if you have mthfr and I have hi homoscytene on blood work was told it had to do with cholesterol. Is the testing for homoscytene connected with cholesterol the same kind referred to reading about Mthfr? I have my kind of high homoscytene a symptom of Mthfr.

  7. Amy August 12, 2014 at 7:13 pm #

    I just found out that I have heterozygous 1298 and 677. What do I need to know and how can I improve this condition?

  8. Miss Micah August 18, 2014 at 10:57 pm #

    I was just diagnosed with compound heterozygous mutations for the MTHFR genotypes c677t and a1298c. My mother was also tested and will receive her results in a month. I am so excited to have my diagnosis as I firmly believe all of my diagnosed diseases should not exist together. I have long QT syndrome with my highest QTc over 605 ms, mitral valve prolapse with regurgitation and bi-leaflet prolapse, Postural Orthostatic Tachycardia, and Neurocardiogenic syncope, chronic hypokalemia, severe vitamin d deficiency (5.2 was my lowest number on a 25 OH Vitamin D test.) Over the past two years, my symptoms have become progressive with multiple runs to the emergency room for hypokalemia and tachycardia and I have lost the life that I was content with leading. After my dx through CompanionDX and my cardiologist who is a researcher and writes prolifically on neurotransmitters, I was put on Metanx, once daily. I feel better than I have ever felt in my life as I have had moderate mitral valve symptoms since age 4. I have not known what it’s like to have a “normal” life or to ever feel “good.” Thank you for such a valuable resource. I now suspect that my excess of adrenaline which was causing my hypokalemia is starting to be balanced by a greater production of my noradrenaline through the regulation of the methylation process. The only way I can describe it is “my cells just feel like they’re working better. My cardiovascular, vascular, digestive, and neurological systems simply feel like they work now instead of being consistently dysfunctional as they were pre-diagnosis. I will certainly be considering the Homocystex if my doctor later deems that I don’t need it anymore. I have so much energy I don’t know what to do with it. Just wanted to share that an mthfr diagnosis has changed my life!

  9. Jean August 20, 2014 at 1:57 am #

    Dr. Lynch,
    I have recently been diagnosed with a mutation in both C677T and A1298C. This diagnosis has answered a lot of the issues I have dealt with over the last 50+ years and that many doctors have not been able to explain before now. I have dealt with depression since my teens, multiple miscarriages, low thyroid, low immune system and inflammation. It has been a consistent problem. I’ve been diagnosed with almost everything under the sun but, until now none of it was understood as one problem – a gene mutation.
    I realize now (towards the end of my 50’s) that it isn’t all in my head. I have been liberated. Although the problem can’t “be fixed” I now have information to work with and can adjust my lifestyle to improve the way I feel and the quality (and quantity) of my life.
    I have also learned over the last few decades that most doctors won’t find the answer – we have to be our own advocates to find the answers.
    I’m glad to have this information. I wanted to laugh and cry at the same time as I was reading the symptoms. Thank God I now know. It’s like the final piece of a puzzle that finally fit.

  10. Kim McDonnel September 2, 2014 at 12:05 am #

    My 12 year old daughter recently tested positive for C677&1298 mutations. This answers a 12 year lifespan of unanswered questions and illness. Not to mention brings into question my own health struggles.
    My daughter was born diabetic. It lasted 2 days till they finally let me have her long enough to breast feed her successfully. By 12 weeks old she was running unexplained fevers with low grade temps. We started seeing patterns of monthly fevers that started as described above and lasted 7 days reaching peeks of 106 degrees Fahrenheit. Her white cell count would be elevated prompting antibiotic use. After years of this coupled with breathing treatments of Zofran and bottles of Tylenol and Motrin my Pediatrician finally referred me to an infectious disease Dr. After months of testing and questions we were given the diagnosis of PFAPA by age 5. No cure, no treatment to speak of so I used my own knowledge of holistic health. She grew out of the fevers but somehow never the syndrome of just not feeling well, pale face, achy, and moody. Lots of soar throats, sinus issues, and strep.
    A year ago I started doing Biofeedback scans on her and discovered asthma. She was prescribed a Dulera inhaler. I started her on several supplements, changed her diet, got rid of carpet, placed an air purifier in her room, and hoped this was the answer.
    About a month ago after going on vacation and not following a gluten/wheat free diet she got sick. She was pale and yellow, having allergic looking hives and difficulty breathing, low grade fever and exhaustion. I did an emergency Biofeedback scan and was told by Tonya at Knoxville wellness center I should test for MTHFR. She believed that from the two previous scans over the last year and the one she just performed that Kiley had both C677&1298 mutations. She was correct. She also believes I have one of the mutations. I’m going to be tested soon.
    She has given us a lifestyle protocol to follow and asked for us to get more blood work. She mentioned Deplin as a possible RX and will be scanning for supplements after blood work.
    My biggest problem has been finding a local Dr. who even knows what this mutation is and what to do about it. My own Father, an OBGYN, had limited knowledge and has been taking a reactive approach with his own patients after multiple miscarriages. I wanted to help my daughter now not after a miscarriage or worse.
    Thank you for having the courage to find an answer for so many questions. So many of us are getting labeled with in curable diseases and given RX Meds to suppress our symptoms. I am spreading the word through my own website and blog. Knowledge is power!

  11. Ric October 25, 2014 at 3:45 pm #

    My Doctor is giving me a shot of the following: methyl tetrahydrafolate, methyl b12 and b complex. I am heterozygous c677t. I am starting off slow with this shot and will increase over time and then to supplements.

    In my reading on your web site, I haven’t read any information about methyl tetrahydrafolate. What is your opinion of treating my mutation?

  12. Janyce November 13, 2014 at 5:08 pm #

    Hello. I’ve been sick most of my life. 61 years old. Female. Just found a Naturopathic Doctor that did a Phase I & II Detoxification. I’m still trying to process the results:
    Methylation = Homozygous positive COMT V158M
    Acetylation = Homozygous NAT2 R197Q
    Glutathione = ABSENT GSTM1 1p13.3
    Glutathione = Heterozygous positive GSTP1 I105V
    Oxidative = Heterozygous positive SOD2 A16V

    My doctor is great but She said she’s never seen an ABSENT and really didn’t know what to do. I don’t know where to go next. Apparently my body can not detox. I’ve always been a ‘highly sensitive person’. Haven’t been test for the MTHFR but thinking I should when I go see her again on the 17th.

    Do you have any recommendations?

    • Dr Lynch November 14, 2014 at 7:38 am #

      Janyce –

      Please check the Find a Doctor page.

      ABSENT Glutathione – I’ve seen that a number of times. It simply means that you need to support yourself with liposomal glutathione and sweat more often – and reduce incidence of exposures to chemicals of all types as much as you can in this world.

      Sauna is absolutely critical and I recommend that heavily – along with electrolytes.

      I recommend High Tech Health Sauna – and if you let them know I referred you, you get $500 off and I get some commission as well which I use to support my research. I personally own their three person infrared sauna and enjoy it.

      1) Sauna
      2) Electrolytes – consider Optimal Electrolyte by Seeking Health – very complete. My formulation.
      3) Glutathione – Optimal Liposomal Glutathione – start low and work up. Start very low – as in a 1/4 tsp away from food near the end of the day.
      4) Castor oil packs – read about this on the web and YouTube – then do it nightly
      5) Liver support – liver supportive foods – read in Google for this and also consider Liver Nutrients by Seeking Health

  13. Dr. Katrina Mulvihill November 15, 2014 at 7:50 pm #

    Hello all and Dr. Lynch,

    Seven years ago, after I was diagnosed with Lyme disease (very weak positive and some physicians suspected that it was a false positive because of previous Mononucleosis.) I was over-treated with heavy doses of antibiotics in both oral and IV form. I became increasingly sicker on the ABX but doctors didn’t believe that the medication was the culprit. I was just advised it is Herxheimer reaction. After seven months of continued treatment, I was very ill and barely able to get off the couch. I took myself off the antibiotics and initially became much better. Almost a year later, when I started to exercise somewhat, I had a massive relapse. I couldn’t even stand up in the shower for weeks. Since then, I have been getting better just to relapse again. Although I am stronger than the first intense attack, I can barely walk 10 minutes.

    I learned from a friend about MTHFR and proceeded to get tested. Results revealed that I am hetero A1298C. The following additional SNPS were found:

    Hetero COMT V158M
    Hetero COMT H62H
    Hetero VDR BSM
    Hetero VDR Taq
    Homo MAO-A R297R
    Hetero ACAT1-02
    Homo MTRR A66 G
    Hetero MTRR A664A
    Hetero AHCY-01
    Hetero AHCY-19
    Hetero CBSC699T
    Hetero CBS A360A

    A few months ago, I started getting monthly B12 shots (albeit Cyanocobalamin), which made me a bit stronger. Three weeks ago, when I learned about a possible problem with MTHFR, I tried 400mcg of L5-MTHF, which also gave me a bit more energy. I have since titrated up to 800mcg and am definitely operating at a higher level.

    This is where I stand today but am not sure what to do about the SNPS. I know that sulfur could be an issue with CBS and am certain the homo MAO-A should be addressed but my physician is not knowledgeable in any of this. I must note here, that I have high loads of heavy metals, which I tried to eliminate with DMPS three years ago, but because it made me so sick, I stopped after 8 IVs, leaving me with still high exposure of mercury and lead.

    In my past, I lead a very active life as an international captain for a large US corporation, ran marathons and did triathlons. I haven’t worked in almost eight years now. Along the way, my decrepit state of health with seemingly no way out made me depressed. I have consulted about 30 physicians in the US, went to a Swiss treatment facility named Paracelsus Clinic, did a two week fast in Germany, tried a purely alkaline diet, various juice fasts, paleo, vegan, generally healthy diet, and more with varying degrees of success. I always seem to relapse at one point or another.

    You might be able to imagine the hopelessness and despair that befalls a person with continued setbacks despite a very healthy life-style. Until now, there were no answers. MTHFR might be a contributor, but my physician assures me that it is not the answer. I would love someone to help me prove him wrong.

    Health and blessings to all,

  14. Nancy Henninger November 29, 2014 at 2:40 pm #

    My babies have MTHFR and develop allergies constantly. They are currently allergic to preservatives including natural ones like vitamin c and I can’t find a methyl folate without preservatives. Any suggestions?

    • Dr Lynch November 29, 2014 at 6:03 pm #

      Hi Nancy –

      I’ve developed many different ways to deliver methylfolate.

      You can find supplements with methylfolate in them here.

      • nancy Henninger November 29, 2014 at 10:33 pm #

        All of the Seeking Health Supplements have preservatives that I can see. Am I missing something?

        • Dr Lynch November 30, 2014 at 12:58 am #

          Nancy –

          The only preservative is found in the liposomal methylfolate and that prevents mold and yeasts from growing. That is a must. The preservative we use a natural preservative.

          All the other supplements do not contain preservatives.

          Not sure what you are thinking is a preservative.

  15. Richard Clark December 1, 2014 at 5:20 pm #

    My wife, Lori, is VERY ILL with what we think is this MTHFR gene mutation. She is at the point of losing muscle control, three months of headaches and insomnia, loss or memory, and neck/jaw rigidity. We need some help immediately — who can we see or contact in the Bellingham area that is the leading expert in this. It is urgent. We would be grateful for an immediate referral or consult.
    Richard Clark

  16. Tunya Sytsma December 10, 2014 at 4:47 pm #

    Aloha, my name is Tunya and I co-own a small fitness club in Hilo, Hawaii. I am a current patient of Dr. Sarah Strong and we have been trying to combat my access fat problem. I am 5’9 and weigh 360 and have been at this steady weight for the past two years. Funny thing about my situation is I use to be over 500lbs and by changing my intake and by inserting an exercise regiment I lost approximately 250lbs by the year 2006. However that all came to a grinding halt November of 2006 with a horrific car accident that left me unable to exercise for over two years. Once I got started again I was just over 400lbs again. I spent from 2009-2011 trying to work that weight off and fighting for every pound lost. I started taking some new supplements in 2011 which helped me shed 100lbs and 130 inches and got me down to the 360 but since 2013 I am at a complete stand still.

    Dr. Strong did some testing and discovered I was at a Level 3 Adrenal Fatigue and I needed some hormone replacement therapy. However, it seemed by implementing these changes still did not trigger any fat loss.

    Here is the funny thing, I am a competitive athlete in the sport of Powerlifting and just one a world title in the WABDL division. What I eat is so important to what I do. I eat a very clean diet with intense weight training six days a week, so it is quite perplexing to Dr. Strong and I why nothing is working now.

    When she offered this new test I jumped at it. Now we have discovered I have the mutated gene C677T. So where do we go from here?

    I have checked and all of my supplements do not contain folate. So we’re good there. Was excited to see on Dr. Ben’s list of things to make sure I am taking in included Vitamin D3 and Curcumin. I have found over the past year that a stack of these two supplements control my chronic hive condition. I have not used Prednisone or my Epi pen since beginning this regiment.

    I will document how I proceed with hopes it helps all those in the future who have similar cases.

    Dr. Ben if you have any suggestions please don’t hesitate to let me know.

    • Tunya Sytsma December 10, 2014 at 4:49 pm #

      There is is no edit button for our post…LOL

      When I mention the sport of Powerlifting, it should have read:

      …..just won a world title


      …..just one


    • Dr Lynch December 10, 2014 at 7:32 pm #

      Tunya –

      I highly recommend reading this book: The Metabolic Makeover

      It’s a bad name but an incredible book.

      Right up your alley as it addresses being overweight, inability to lose it and fitness.

      Blocked methylation can obstruct weight loss – and so can inflammation.

      If you have inflammation or food intolerances/allergies, then you will hold on to the weight and not let it go.

      Your fat burning is not working – and need to restore that. The book will help guide you.

      You will have to alter how you eat – and when you eat – and the book will help immensely.

      Start there – then let’s revisit!

      • Tunya Sytsma December 10, 2014 at 7:41 pm #


        I will definitely take a look at this.

        Just a little further info: I have been following a gluten-free and no milk (only Almond or Coconut milk) regiment for the past three years. Also, after being diagnosed with the adrenal fatigue I dropped the Greek Yogurt and cheese. I already eat only grass-fed meats, my butter is Kerrygold (as of 3 years ago), and my intake is primarily sweet potatoes, rice, gluten-free pasta (once in a while), lots of veggies, MCT oil (Bulletproof) and then just my training supplements.

        I have been wondering about my timing, so I look forward to seeing what this book as to offer. Heading over to Amazon right now.

      • Tunya Sytsma December 23, 2014 at 5:49 pm #

        Since your reply a couple of things have happened:

        1. I have finished reading the book that you recommended. Very technical, but highly informative. I learned there are quite a few things that I will need to add to my arsenal.
        2. I am a patient of Dr. Sarah Strong. Dr. Strong indicated that she mentioned me to you. She has started me on the Folate supplement. I have been taking a 1/4 dose since last Wednesday.

        From reading the book I have a couple of questions.

        1. As a female, how much Resveratrol should I be taking a day? The book mentions 150mg per day was beneficial in 2011, but I am guessing that is based on the average person with average weight. Biotest carries this product but I am guessing that there dose is based around the male need. My hormone testing does show an elevated amount of estrogen. Biotest product is sold in 3 capsules per serving and a recommended dose of 600mg per day.
        2. As a female competitor how much Creatine do you recommend and when do you recommend it be taken? I am sponsored by Biotest and they offer Creatine Monohydrate and Creatine Malate (no bloat). Do you prefer one over the other? Biotest recommends 5-10mg per serving and taken directly before or after a workout.

        I already eat small meals and depending on the length of my day to how many I get in. I wake at 3-3:30am every day. Six nights out of the week I get to bed by 8pm.

        I lift five days a week and a sixth day is devoted to conditioning. Sunday’s is generally my day off from the gym and is spent doing house work and prepping for the next week.

        90% of the time my training is first thing in the morning and will consist of approximately 60g of carbs and 31g of protein prior to training; with approximately 20g of carbs during training (all from a Finibar and dose of Plazma). I generally follow this up with a dose of MAG-10 (11g Carbs + 20g Protein). Both the Plazma and Mag-10 are made with 500ml of water.

        The rest of my day is generally made up of protein, veggies and healthy fats.

        A heavy training day breakdown be as follows: 200g Protein, 150g Carbs, 100g Fats, 25g Fiber. This happens 3 of the five lifting days. 2 of the lifting days the protein drops to 160-180g of Protein and 120g of Carbs. I tend to keep Saturday and Sunday very low carb, dropping all training drinks/bar and keeping to just a dose of MAG-10 for my conditioning session. Sunday’s I do several doses of MAG-10 and the rest of the intake consists of protein and veggies with my intake staying at about 1000 calories.

        I look forward to any suggestions you have to give this whole new year a great beginning as I get my mutated gene in line with all of my other training and nutrition.

  17. Donna January 18, 2015 at 7:52 pm #

    Siblings have had memory problems but mine is sadly nonexistant-anyone else have this
    I am homozygous C677T

  18. Rebekah October 12, 2015 at 4:32 pm #

    I have recently tested positive for the Single Copy of A1298C gene mutation. My two small sons (4 & 2 years) were also tested positive for the same exact mutation.

    In all of my reading from Dr. Lynch, this seems to be the gene mutation that does not seem to cause problems.

    Does anyone know if that also means that I should NOT be supplementing? Or does that mean I should still be using methylfolate?

    • Dr. Aron October 21, 2015 at 11:19 pm #

      Rebekah – Supplementation largely depends if you are not getting sufficient methylfolate from food (leafy greens especially). If you and your sons are eating a diet rich in vegetables and whole, unprocessed foods, you may not need to supplement. Supplementation fills in the gaps when whole foods are not enough. Diet, exercise, stress, and environmental factors all influence whether a gene is expressed. So if all of these lifestyle factors are in order and your sons are healthy and happy…you likely won’t need to supplement.

  19. Amy December 11, 2015 at 5:00 am #

    Hello…would like to float this by you and others for feedback, Just learned that I am heterozygous for C677T & A1298C mutations.
    I just started Deproloft -HF by Thorne. Recommended by a provider I trust, Recommended dose is 2 tabs 2x a day.

    Hours after taking 2 Deproloft in the morning, my face turns bright red and I get a very warm/slight burning/tingling sensation on my thighs and backs of my arms. Along with heightened arousal.
    A reaction similar to eating something I am allergic or sensitive to – and similar to the reaction I had once when I accidentally took 2 B complexes.

    Am curious if my reaction to the supplement is common. And would like to better understand why I am reacting this way. Was excited to take it for mood, but not sure I can handle it.

    Thanks for any thoughts!

  20. Halina Warwas December 31, 2015 at 7:52 pm #

    I would like know, what we can do with 3 years old child wit hetero C677T and hetero A1298 C. How many mg can she take of folate and methylocobalam. Her mother has the same and she is taking 400 mcgq folate and 1000 mcq methylcobalamin. Halina Warwas

  21. Tara jo January 20, 2016 at 2:12 am #

    I’m 32 and been married for two years. When we first got engaged is when I got diagnosed with the mutation. I got tested because I went to a hematologist because I had had several blood clots in a year.I got my tubes tied immediately and went to see a fertility doctor like to talk to me more about the mutation, that is when he first put me on folic acid I was taking for a while but wasn’t feeling any better or any worse so I stopped at. To top everything off I had endometriosis diagnosis during my tubal ligation and was some so horrible side effects of my endometriosis. For the past six months I’ve been taking Depakote Lupron for my endometriosis and now have been reading more that taking the devil Lupron could make some more side effects my struggle is trying to find out the right vitamins to take to help with my endometriosis, my moods, and my mutation.

  22. Rebecca B January 25, 2016 at 2:07 pm #

    Hi, my name is Becky. I am a 34 year old mom in Ohio. The past 11 years have not been easy road to haul, however I am a survivor. Let’s go back to where it all began for me. I was a new mom of a healthy beautiful baby boy in late June 2004, although the happiest time in my life, it changed drastically over those two weeks. On July 3, 2004, I had a stroke. I could not talk, walk, or tell by husband what was wrong. Fortunately for me, my husband had that day off and was quick to take action and got me to the hospital. That was the most scared I have ever seen my husband. After a few weeks in the critical care unit at the hospital, I came home, however; it was not long before I was back.
    In Late July 2004 I was awakened suddenly one morning with a sharp pain in my chest and gasping for air. I didn’t know it at the time, however I later found out that I had a Pulmonary Embolism (PE). The doctors said it passed through my heart, however; if it was any bigger, would have stopped it completely. I found myself back in the hospital once again. After several tests and blood thinners, I was back to breathing as normal as I could. I can honesty say, my lungs have never been the same.
    I jump slightly forward to August 2004, the past several weeks have not been joyous as they should be for a new mother, I began to have pain in my right leg. Not thinking anything of it, because I was already on blood thinners I went to bed. The next morning, I awoke to my leg being red, sore, hot and about 5 inches bigger in size than my left. I had no clue what was going on. We immediately go to the ER and we’re advised of me developing a Deep Vein Thrombosis (DVT). This was no ordinary blood clot mind you, it was thick, and stretched from my ankle up past my groin. What could have happened, this wasn’t here a week ago when a doppler ultrasound performed? But there it was smack in the middle if my leg. The doctors tried to get it by going through the back if my leg and hulking it out, but it was too thick. Instead the team decided to go in through my jugular vein in my neck all the way down to my knee. They hit it with blood thinners and sacked it out piece by piece.
    Even with all I had happen, I was told that I had Lupus…what? Lupus, what’s that? I thought. I was out on anticoagulants and that was the end of it. I went for weekly blood draws for the next 9 years, but was never quite “therapeutic”. It was then that my doctor said, I want to have a test done to check on this “Lupus”. He said, let’s narrow that down to see exactly what is going on. Now I was told there are 8 types of Lupus variances. But what surprised me the most of all, is after 9 years, I was told I don’t have Lupus afterall. Wow, I was amazed and excited of this news. Yes, I proclaimed, nothing is wrong with me. However, that wasn’t the case. I came to find out that it wasn’t Lupus Co trolling my body. That I, this young mom, someone who, although overweight active mom….was a mutant? I was advised that I have this genetic mutation called MTHFR. That was the first day I have ever heard of that. The doctors said I have two variances homogenous A1298c and C677T.
    I was in shock. How did I? Why did I? Could my son? Questions that still come into my mind today as I travel this path.
    I mention this to even my doctors, but they don’t know anything about it. What to do, how to treat, what to eat, what to prescribe. These are all answers that I fear, I must find on my own now.
    I know I am not alone, and I apologize for my long story. This is something that I am passionate about. If our family doctors can’t help me because they don’t know, then it’s time to make this awareness happen.

  23. Jessica Boos January 27, 2016 at 4:29 pm #

    I’m here because my sons test results just came in. The Dr. told me that he tested positive for all components of Mthfr and both myself and his father Are carriers. (We’ve had some concerns with our son. He’s an extremely gifted child, but has had some development and behavior issues, so dr wanted to test for this.). She wants to start treatments with folate. So my journey is just beginning today. Need to find out if treatment with folate is best for him.

  24. Amy March 8, 2016 at 12:51 pm #

    I have histamine intolerance, gut dysbiosis, leaky gut, and METHFR issues…just homozygous. Currently treating with strict diet, DAO, L-glutamine, liposomal Vitamin C, Liposomal Biocidin, and ordered methylation support products as per my doctor. She suspects I have SIBO. If treating the gut, isn’t SIBO treated without testing? Also my blood showed Candida antibodies, but no Candida in gut. Can Candida be in the SI and not in the gut? Also blood test showed some Mercury and slight Lead. Is it necessary to do heavy metal test and treat with chelation?

    • Dr. Aron March 12, 2016 at 7:50 pm #

      Amy – SIBO can typically be tested via a hydrogen breath test to determine if bacteria from the large intestine has migrated to the small intestine. Candida infections can affect almost any part of the body–GI tract, skin, mouth, blood, etc. Heavy metal testing might be indicated if your doctor thinks the mercury and lead levels are high. Reducing levels of toxic metals is always a good idea. There are a number of ways todo this by minimizing exposure as much as possible and helping your body excrete these metals via chelation, sweating, plenty of fiber in the diet, or supplementation.

  25. John July 23, 2016 at 6:46 pm #

    I am a 50 year old male with no desire or energy to function. My Compass Laboratory Service Test shows 677C>T and 1298A>C have reduced MTHFR activity. My 2C19 gene is an Intermediate Metabolizer and my 3A5 is a poor Metabolizer. I also have a Intermediate Warafain sensitivity. Other genes tested seemed normal. I had a B12 and Folate test completed and it is normal at 435pg/ml and 18.1 ng. However, I have tried 3 different anti-depressants at low and high dosages and they did not work. (Lexapro/Brintellix/Pristiq). I am waiting on another test from Genomind. What should I be looking for on the new test to assist with understanding what will help me get my life back. I have a family member that was placed on Deplin as an alternative and they are doing great.

  26. Jen July 29, 2016 at 10:25 pm #

    Hello Dr Lynch-
    After two misscarriages (between7-10 weeks). I advocated with my GP to test me for MHTFR. I am homozygous for c677t. My OB does not believe this has anything to do with misescarriage but I disagree. I have switched from a high folic acid prenatal to a methyfolate prenatal and have been gluten free. I take Wobenzym n, a probiotic and fish oil. I am now successfully 16 weeks pregnant. I had dehydration so my ob recommended I take emergenC and after taking for 5 days I realized it had folic acid in it! Is there anything I can take to get rid of it? I ordered the seeking health electrolyte supplement. Also is it safe to take the liver support from seeking Health while pregnant?
    I appreciate all of your work.
    Kind Regards,

  27. LisaMD August 25, 2016 at 4:22 am #

    What’s up Dr. Ben!
    I found out 3 years ago from my amazing psychiatrist that I am PROUDLY homozygous for C677T MTHFR!!!!
    This was extremely eye opening for me. Since I was 4 I was prescribed the legal maximum amount of Ritalin. And now, after proper diagnosis I take 15mg of Deplin. I have not had a panic attack in 3 years. I take a lower dose of vyvanse for my ADD. I’ve had the will power now to lose 51 lbs, and keep it off. In successful at home and work. And every chance i get, I try to encourage others to research MTHFR and get tested!
    I LOVE what you are doing here, MTHFR saved my life by saving my SANITY. Feel free to contact. I’d love to help pass out info.

    • Dr Lynch August 25, 2016 at 11:54 pm #


      So happy for you – and proud of your amazing psychiatrist for pointing out MTHFR. Game changer!

      Key point here – as you improve, you may need less methylfolate. So you may need to taper down to 7.5 mg Deplin and then even lower yet – as you get healthier.

      So if you find yourself getting crazy – – then consider tapering down with your doc ๐Ÿ™‚

      Your psychiatrist may love our new genetic report – StrateGene – please show her this and watch the videos. – it’s very powerful

      Keep humming along!

  28. Elissa Shapiro September 7, 2016 at 9:16 pm #

    HI there, Thank you so much for all of this extensive information. I had one healthy child 4 years ago and then have had 3 miscarriages this last year and a half. I have the C677T and A1298C mutations, and also have ulcerative colitis and am on the medication Lialda. I’ve recently read Lialda lowers folic acid levels. Is this a problem and any suggestions? Thanks!

  29. Diana September 24, 2016 at 6:47 pm #

    Has there been any link with MTHFR and nausea and vomiting in pregancy?

    • Dr Lynch September 25, 2016 at 6:58 am #

      That’s a great question. Not that I have seen – but I suspect there are issues with folate and choline metabolism as nausea and vomiting are reduced when a pregnant woman is supported with protein and vitamin B6 usually.

      Protein supports methylation –

      If supplementing with liposomal vitamin C or some phosphatidylcholine, the nausea of pregnancy may diminish.

      I need to study this area but I believe my theory here (and likely not the first one to think of it) is right.

      • joao October 5, 2016 at 5:25 pm #

        Dr Lynch

        I have a suggestion
        It would be great if allows us to sort the forum’s results by number or posts/replies.

        At there is no way to do this. I would like to read first the question that has more aswrers. thanks

    • Kathleen March 20, 2017 at 7:15 pm #

      Michigan, need good doctor in Detroit suburbs/ michigan that focuses on MTHFR and prothrombin. Survivor of a PE and Great Cancer and happen to be a RN and researcher. I used to see Dr. Judith Anderson at Karmanos Cancer Institute but she has since retired.

  30. Nikki November 23, 2016 at 10:33 pm #

    Does anyone have any information about MTHFR mutation and retinal vasculitis? My mom has unexplained retinal vasculitis that has caused her to lose vision in one of her eyes due to hemorrhaging and the doctors have no idea what is causing it. She is due to go for surgery to drain her eye so they can see what is going on and hopefully prevent loss of vision in her other eye. She has had this problem for the last 20 years… Through my research for myself and my children I’m wondering what the chances are there is a link between the two. The docs want to put her on methotrexate but I was reading there is a possibility of toxicity. I can’t understand the scientific jargon in the online articles so I’m hoping someone may have some info. Tia!

  31. Rebecca November 26, 2016 at 5:11 am #

    My daughter was diagnosed with compound heterozygus MTHFR last year. We have been following the dietary restrictions for gluten and dairy since then. She is very reactive to chlorine in swimming pools, has ADHD tendencies with sensory integration issues. I am very concerned about her for the future. I feel like we are still missing something, as she still struggles at times with behavior/emotional management. I am finding it hard to discern what foods and beverages are “safe” for her, even the organic 100% juice boxes are fortified. She takes a methylfolate supplement and a low dose of GABA. I am hopeful that we can continue to learn more about her specific needs so that she can thrive.

    • Dr Lynch December 3, 2016 at 3:55 am #

      Hi Rebecca –

      I recommend ordering the 23andMe test and then run her raw data through

      Working with a health professional trained in this area could be a huge step for her.

      Consider Bernarda Zenker, MD

      Definitely be 100% gluten and dairy free – no exceptions.

      Need to look at digestive function also – CDSA is a great test – from Genova along with the organic acids test from Great Plains.

      Lithium could be useful as well – low amounts.

  32. Rachel Brooks December 9, 2016 at 4:36 am #

    Hi there,
    I recently found out I have MTHFR. I’m not aware of what specific type yet. Hoping to gather more information soon. I meet with my OBGYN tomorrow, and a Fetal Specialist next week. The nurse gave me very vague information over the phone. Two other abnormalities popped up on my blood work. Positive protein S antibody and positive russell venom test. Do you have any information regarding how these may correlate? Or what are some key questions I should ask my doctor regarding this news? …

    I have had two healthy, successful pregnancies bringing about two beautiful kids with seemingly no problems or MTHFR symptoms/ side effects. I thought I was in great health until miscarrying 3x over the past year. But thankful to have an answer to why this happened and hopeful moving forward.

    Thank you!

  33. Maria December 11, 2016 at 3:36 am #

    Hi Dr Lynch, Can you tell me if you think an MTHFR mutation is connected with Multiple Chemical Sensitivity? and if so can you briefly describe your thoughts on the mechanism/ biochemistry and perhaps your suggested protocol?


    • Dr Lynch December 15, 2016 at 3:28 am #

      MTHFR is needed to support methylation, balance homocysteine and support glutathione levels. In those with MCS, it is common to see homocysteine issues, low glutathione and insufficient methylation. So – yes I see MTHFR being connected – absolutely.

  34. Amy Vincent December 12, 2016 at 10:28 pm #

    I have MTHFR c677T homozygous mutation. I’ve been taking a liposomal B12/B complex and feeling better since I started that about 2 months ago. Last Friday, I got my mercury amalgam fillings removed (correctly, by a biological dentist) and I’m having some extreme symptoms since the removal. I am on the Quicksilver Detox Qube for mercury detox. I was looking up my symptoms and found some information that taking B vitamins, specifically B12, converts the mercury from the amalgams into a more dangerous form and causes horrible symptoms for those with elevated mercury in their body. Do you have any advice on this- should I stop taking my B supplements until I finish the mercury detox protocol?

  35. JAX January 21, 2017 at 2:49 am #

    Thank you for posting this. I’m a blogger and a freelance writer, who recently started a new blog about my journey to healing. I found out a few months ago that I’m a carrier of this gene and sifting through the host of information on the Internet has been challenging and overwhelming, sometimes. Although, some of your videos can be somewhat over my head at times, since I’m not a physician, I really appreciate this step-by-step list of where to go next.

  36. Leah February 16, 2017 at 9:11 pm #

    Hi there! I’ve been suffering with anxiety and mild depression since I was young. Currently take Lexapro and Buspar and Xanax (for panic attacks if needed). I mentioned to my psych that I have the MTHFR mutation and she recommended Deplin. I asked to try Enlyte or Enbrace HR first and she obliged. Have you any experience with Enlyte or Enbrace HR? She also recommended B12 but after my first dose I felt awful (nausea, headache and jittery for a few hours). Thanks for all your research and help understanding this!

  37. Scott R. February 20, 2017 at 7:52 pm #

    Great webpage!
    Need Help!
    15 Days taking Enlyte and I feel drowsy and tired with a little brain fog. My anxiety, rumination, and depressive swings have calmed which is good and why I started but I am worried where I am headed.

    I am homogeneous for C677T which I learned about from an analysis of my genetics by a Genetic Nutritionist. I have other homogeneous variants but not listing now as I don’t want to confuse this post. If knowing of something in particular would help please let me know. A psychiatrist recently verified this from his own genetic test for psychiatric medication compatibility. He prescribed me Enlyte as I recently have been batting depression but realize I probably have my entire life.

    Why am I tired & foggy? What byproducts am I now producing from the boost in my methyl process that I am not processing?

    • Dr Lynch February 24, 2017 at 2:07 am #

      Im not a fan of Enlyte as it has folic acid in it.

      Please read this –

      • Scott February 24, 2017 at 3:38 am #

        It has l-methylfolate the active form of folic acid right? The idea is don’t convert folic acid to the active form so they put it in the pill. Maybe I’m hoping and thus imagining it is working but I do feel more even emotionally and ruminating less so maybe I’m methylating better now and my neurotransmitters are creating serotonin

        • Scott February 24, 2017 at 3:42 am #

          I also wanted to add that I was told I should take the Enlyte in the morning instead of at night because the serotonin it’s creating turns into melatonin and that could be why I was getting tired in the day. I have not been so tired in the day now.

  38. Cathy Thomas February 23, 2017 at 1:55 am #

    Dr, Lynch so happy to find this, recently diagnosed with hetero 677/1298 also hashi’s hypo. I took the Boston heart test/ program and it has a lot of info related to cardio not much on some of the other things people have found out so I will need to look into those things later. I have a great deal of concerns with my estrogen which is non existent, but I also tested with a low t3 uptake indicative of estrogen dominance- obviously I’m not. Finding any information on low estrogen is almost impossible, the low uptake combination lead me to a possible hepatitis issue. My research of the cardio, homocystine, estrogen, thyroid ect all go back to the liver once again I can find little to no info. My tests indicate low inflamation but everything else says NAFL. 2 family members have died of liver cancer another is battling it, so I am concerned. Can you point me toward an information source.

  39. Melissa Feinberg March 22, 2017 at 12:27 am #

    My son 16 diagnosed with hashimotos at around 8 placd on levothyroxine. Many testing found MThfr gene c. Now has elevated A1c. Doctors keep trying to push metforim when all readings say it can harm not heal. He is on supplements but I just cant feel comfortable with any Dr whom seems to understand. recently saw doctor whom declares to be homeopath, she placed supplements and said she had no problem with metforim. i reminded her of my son’s genetic disposition and she seemed still unaware of any problems. Help. My son is frustrated feels like he cant eat anything scared that he will end up on insulin. I know there is a more natural approach to his healing.

  40. SSTK March 24, 2017 at 1:17 pm #

    Is it safe for me to take the liposomal glutathione as I suffer from migraines from soy, fermented foods, MSG and free glutamates in tomatoes and mushrooms, citrus etc (suffering for 35 years) and also have a big problem with histamine (hot flushes, tight chest, nosebleeds when asleep, tonsillitis before cutting out dairy (I am now vegan and have been for 20 years). Am compound herterozgous for MTHFR with other major variant dramas. Thank you so much for your videos and website. They have been incredible as was your Stratagene. Thank you. Your report on my genetics makes so much sense. I didn’t know I was a carrier of haemachromatosis and wondered why I was getting liver pain. Now I’m having it checked by ultrascan. Thank you so much.

  41. Angela March 26, 2017 at 3:04 pm #

    My 7 year old son is compound heterozygous…we had delayed most vaccines even before testing. I am elated that I held strong in my beliefs when they were questioned. We are now playing catch up with the immunizations I feel are essential (he has completed polio, HIB, pneumococcal and needs varicella and MMR). We are planning a trip overseas so these will be done in the next few months. Any suggestions on detoxification between vaccines for children. I am treating my non tested 4 year old the same.

  42. Karma77 July 5, 2017 at 7:42 pm #

    I am type 2 diabetic so I supplement with b12 injections and methylfolate 1000mcg/day. Since Im on Metformin do I need to increase my methylfolate dose?


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