Recurrent Pregnancy Loss and MTHFR

There is no doubt that MTHFR and recurrent pregnancy loss are linked.

This is especially true if you have:

  • 1 or more copies of the C677T MTHFR mutation or
  • 1 copy of each (1298 and 677) or
  • 2 copies of A1298C or
  • A single copy of A1298C MTHFR mutation may not be related – however, I am still on the fence about this for various reasons.

I recently came across an article regarding a 31 yr old woman who had 3 recurrent pregnancy losses in 12 months. She was tested positive for 1 copy of a MTHFR variant (which form is not clear).

She was inappropriately prescribed high amounts of folic acid.

What should have been done?

In my experience, doctors should prescribe methylfolate and folinic acid to pregnant women.

How much?

It depends on the MTHFR variant, lifestyle, diet and symptoms. There is no set guideline to how much. One must taper up or check their blood levels for various forms of folate.

The point I want to make is there are certain guidelines for recurrent pregnancy loss and MTHFR.

I am not an OB/GYN or a specialist in recurrent miscarriage so in order to provide you the best information, it is best that I find someone who is.

I’ve done that.

1. Edward Ramirez, MD, FACOG
2. Reproductive Immunology Associates

You ask: What is FACOG?

FACOG = The initials FACOG after a physician’s name indicate that he or she has met additional criteria to qualify as a Fellow of The American Congress of Obstetricians and Gynecologists. By choosing an ACOG Fellow as your physician, you can feel confident that you will receive the highest quality health care. Choosing an ACOG Fellow as your physician ensures that your ob-gyn is being kept abreast of the latest medical guidelines, treatments, and techniques in women’s health care today.[1]

To make this as clear as possible, I am going to now provide you the Q and A[2] that occurred between D from Boston and Dr Ramirez:

Dear Dr. Ramirez,

I am 31 years old and have had 3 chemical pregnancies in the past 12 months. They have run a slew of genetic testing and a RPL (recurrent pregnancy loss) workup and all has come back normal with exception to the MTHFR test. I have tested positive for 1 copy of the MTHFR mutation. The nurse told me that because I was considered heterozygous that this was not a big deal. They prescribed me with a high dosage of Folic Acid. She said that it was likely not contributing to the repeat losses. I have been reading online and while the homozygous mutations seem to be more serious, there seem to be mixed reviews on whether this can contribute to early miscarriage.

Do you prescribe Lovenox or Heparin in this type of situation (only 1 copy?) Should I be concerned about this and demand that they treat it somehow? It doesn’t seem like they are planning on doing anything besides the folic acid.

Also, given that this test has come back as it did, is there any other testing that you would reccommend that may be related to this? I am a little frustrated because this test was not originaly included in the work up and I had heard about it from online research and specifically requested it.

I just want to make sure that I am not missing anything.

Thank you,

D. from Boston


Hello D. from the U.S. (Massachusetts),

The treatment for MTHFR (Methylenetetrahydrofolate reductase), is increased Folic acid (for more information But with your history of recurrent pregnancy loss or RPL, I usually will add the following to my patients, although there is not clear research backing it up if you are immunologically negative:

1. Low dose aspirin 81 mg starting with the start of the cycle

2. Low dose heparin 2000 units bid starting with the start of the cycle (you can substitute lovenox but it is more expensive).

3. Medrol 16 mg starting with the beginning of the cycle until ovulation then decrease to 8 mg

4. Increase progesterone supplementation of either Crinone 8% per day or Endometrin 100 mg three times per day starting after ovulation.

This cocktail has been shown to be effective in recurrent miscarriages (see Reproductive Immunology Associates for further information regarding immunological causes of miscarriage). My presumption is that you have had immunological testing, specifically antiphospholipid antibodies?

I hope this helps!

Good Luck,

Dr. Edward J. Ramirez, M.D., FACOG


You may have noticed Dr Ramirez stating that the treatment for MTHFR is high dose folic acid. Well – it is – unfortunately. This is the standard of care which physicians are forced to abide by. You notice that Dr Ramirez mentioned to visit for more information. That is all I’ll say about that.

Proactive doctors who are ahead of the standard of care know that high dose folic acid is cause for concern. Not only that, but folic acid is not the active form of folate that is needed for a developing baby. The forms of folate that are needed for a developing baby are folinic acid and methylfolate.

Moving on…

Why would Dr Ramirez provide aspirin and heparin (or lovenox) for a woman with 1 copy of a MTHFR variant?

Because this woman had recurrent miscarriages. Period.

We know that D from Boston had recurrent miscarriages and the ‘only’ thing that showed up in her bloodwork was 1 copy of a MTHFR variant.

What we don’t know is:

  • What other relevant blood tests were not done?
  • What tests should have been done on her partner? It is not only the woman’s genetics that can cause miscarriage. The man may donate genetics which can recurrent pregnancy loss.
  • What is her lifestyle and diet like?
  • What is her occupation?
  • Are her environmental exposures partially at cause here?
Regardless of all of these, if a woman experiences recurrent pregnancy loss, then why not be proactive and assume that there are underlying clotting disorders, unknown MTHFR variants, and/or clotting disorders passed from the partner.

To understand my point in detail, one must read this article on recurrent pregnancy loss and how it is important to identify the genetics of the man also – not just the woman.

If your doctor is not being proactive in addressing the known (and unknown) causes of recurrent pregnancy loss, then it is time to educate them on it and/or find a new doctor.

Resources for Recurrent Pregnancy Loss:

1. Edward Ramirez, MD, FACOG

2. Reproductive Immunology Associates

Please comment below your experiences of recurrent pregnancy loss

  • How your doctor has been either proactive – or – underactive.
  • If your doctor was proactive and you successfully carried to term, please do share who your doctor was.
  • What was done medically and nutritionally for you in order to carry to term?

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41 Responses to “Recurrent Pregnancy Loss and MTHFR”

  1. helen March 6, 2014 at 12:54 pm #

    Hello, I am just recently 36 and after suffering my 4th miscarriage I have been diagnosed with Heterozygous MTHFR (unsure which one yet) and High protein C.
    My fertility doctor has put me on baby aspirin and 5mg Folic Acid. Also my last pregnancy he had me on shots of Clexane ( a heparin derivative) – I still lost at 8 weeks.
    After doing some googling I am wondering if I should be taking methylfolate instead of Folic Acid but unsure in what dose. I know that I must be converting some of the folic acid I am taking but if I swap it for methylfolate would I still need to take 5mg… seems a lot and because I am so close to beginning my next and final round of ivf ( emotionally and financially we are unable to do more…) I need some advice so not to over methylate.
    Also what dosage of methylcobalamin should I take along side with the methylfolate???
    I raised all of this with my doctor but he just said that Folic Acid is the only thing I needed for my MTHFR, and looked at me like I had 5 heads when bringing you methylfolate and methylcobalamin. Now I feel unsure if I should question him at all. He is one of the top specialists here in Australia and I am very lucky to be seeing him.
    Please can anyone out there help me. I need to do all I can to avoid another miscarriage and feel like no one understands..

  2. Claudia June 30, 2014 at 7:07 pm #

    Hello. I have recently been diagnosed with two copies of the c677t mutation, after experiencing my third consecutive miscarriage. Two different REs in my area are adamant that MTHFR is not contributing to my losses and refuse to advise anything other than upping the folic acid in my supplements. I have since started taking a prenatal vitamin with methylfolate and increased B12 instead, along with altering my diet as per the recommendations on your website. My question: aside from following the diet and supplement advice is there anything else I should be doing? Will I need lovenox shots in the event I conceive again? My homocysteine levels tested as “normal.” There are no MTHFR doctors listed in my area on your website unfortunately and I feel very much on my own. Like Helen above, I desperately need help to ensure I am doing everything I can to avoid another miscarriage.

  3. Katye July 12, 2014 at 9:13 pm #

    Can you recommend any specific articles to help convince my OBGYN about the necessity of starting heparin? I had a 2nd trimester miscarriage last year and my doctor sent me to a maternal-fetal medicine specialist who literally knew nothing about the MTHFR gene mutation and when I pointed out to her that I was not only compound heterozygous for that mutation but the prothrombin mutation as well, she admitted she wasn’t aware it increased the risk and after looking it up on “Up to Date” in front of me told me just to take baby aspirin. After the miscarriage (and my almost dying) the doctor told me that “next time” I would have to take blood thinners as it was most likely caused by a clot. How frustrating when I tried to tell them to begin with. Anyhow, it seems that the recommendation is to start heparin when trying to conceive, but that isn’t something she seemed open to.

  4. a September 9, 2014 at 11:43 am #


    I am exactly in the same situation as D. from Boston. What do you recommend doing in such a case?


  5. Jennifer November 11, 2014 at 3:19 pm #

    I am new to all of this… just found out that I am heterozygous for both C677T and A1298C. I am curious about the idea of my miscarriages being related to this…. I have had 5 miscarriages, but I have also had 8 live births… All of my miscarriages, except the last one were while I was nursing a toddler, and I have always believed that it was low progesterone that caused each one. I used progesterone cream, without the doctor’s knowledge (because I did not believe they would agree) with my last four full term pregnancies, including one pregnancy that occurred while I was nursing a toddler. I did not have any clotting issues, however, during my last 5 pregnancies, I did develop mild idiopathic thrombocytopenia. It did not cause any problems for me.

    I had four pregnancies without difficulty, then 2 m/c’s, then a full term pregnancy, then a m/c, then two full term pregnancies, then a m/c, then a full term pregnancy, then a m/c.

    From what I experienced, I very much think that if my MTHFR was related to my losses, then it was related to my inability to have a high enough progesterone level while lactating…. My losses were all early, and unlikely to have been clotting problems. I am now getting ready to enter into menopause, and I am struggling with continual hormonal problems. I am very curious about how this all fits together.

    Also, I have 8 kids who most likely, do have some expression of MTHFR ( none tested at this time.) I am a little overwhelmed with how to proceed to ensure that they are able to have good health in the future, and would not like to see them have to go through pregnancy loss. I haven’t seen anyone on any of these posts who has a large family. It would be nice to connect with someone who understands, not only the health implications, but also the financial implications of trying to keep one’s family healthy.

  6. Kate March 2, 2015 at 9:55 pm #

    Hi Dr. Ben,

    I’ve had two pregnancy losses (10 weeks with heart tones and then again at 9 weeks with heart tones). My partner and I went ahead and went to a reproductive endocrinologist and got the full work up. Everything on his end came back normal/negative.

    I had some strange things come back, but an important one is that I’m compound heterozygous MTHFR (homocysteine levels looked great luckily). I also tested positive for anti-nuclear anti-bodies at an extremely low number with a very sensitive titer (no history of autoimmune issues in my family and no signs/symptoms in me). I also tested positive for an unidentifiable RBC antibody in my blood typing/Coombs test (they were unable to determine what it is after multiple draws and suspect that I could potentially have these because I have a lot of tattoos, weird eh?). I’m Rh positive, no history of transfusions, no hemolytic disease of newborn, no major surgeries, nothing like that.

    Our doc determined the course of action (for the next time we get pregnant) to be the following:

    1) Baby aspirin (81mg once per day)
    2) Prometrium suppositories 1-2x daily depending on levels
    3) MetanX
    4) Frequent blood tests and close monitoring

    I’m making a running list of questions for the next time we do conceive and I’m wondering these things:

    – Should I ask about Nattokinase since I won’t be on Lovenox? It seems minimally invasive.

    – Will I have any negative effects on the MTHFR end of the spectrum if my ANA levels go up and I get put on prednisone and antihistamines?

    – Should I ask about Lovenox since it seems other doctors are prescribing it as part of the “standard” catch-all protocol?

    Thanks a bunch, Dr. Ben! Your website is wonderful!

  7. mb23mom April 15, 2015 at 4:19 am #

    Hello, I have MTHFR C677T homozygous (2 copies) and I just gave birth to a healthy baby. I had had two previous early miscarriages and 1 chemical pregnancy.
    My regimen: Prenatal pills, Folate (L-5-MTHF, metafolin or vit.B9 – same thing) – 4,000 mg per day, Vit B12 as methylcobalamin – 2,000 mg, B6 as pyridoxial-5-phosphate – 50 mg, Fish Oil – EPA 1000 mg DHA 400 mg, Baby Aspirin – 81 mg, Lovenox shots 40 ml once a day before going to bed. Progesterone cream 100 mg vaginal suppository daily in the morning.
    Progesterone stopped by week 14th.
    Lovenox stopped by week 16th.
    Aspirin stopped by week 35th.
    I purchased all vitamins on SeekingHealth website. I spent so many nights on this and other websites reading comments of women desperately trying to get pregnant and give birth to a healthy baby – all in between my recurrent miscarriages, that I promised to myself I will go back and post my success story. Good luck!

    • Nicole October 31, 2016 at 3:04 pm #

      Hi I also have the MTHFR C677 homozygous gene mutation and I’m currently misscarrying my first time. I was taking the Thorne prenatals actually I doubled it so taking double what the prenatals where giving me. But I didn’t do the rest that you mentioned in what you wrote. How did you figure out your regimen? Did you have different tests done to figure this out? You can either respond on here or email me at Any information you can share would be greatly appreciated! I’m being super proactive because I’m already 39. Thanks!

  8. simone binder June 23, 2015 at 8:22 pm #

    I have a history of infertility and repeat pregnancy loss (3 chemical, 1 at 12 weeks, and last year at 26 weeks). I have had numerous blood clotting tests but to my knowledge, never been tested for MTHFR. At my 12 week loss, genetic testing of the fetal tissue showed no genetic reason for fetal demise At my 26 week loss, my blood tests showed cardiolipin AB IGM to be slightly elevated at 22. I just turned 44 and fear my hope is gone for ever being a parent. However I really want to know why I wasn’t able to conceive and maintain a pregnancy. What are the MTHFR tests that I should take? Do you have any advice on how to proceed? In one post you mentioned gluten issues. I had done several cleanses and was relatively on a gluten free diet when I got pregnant naturally (and carried the farthest at 26 weeks). Do you think this is a factor?? Thank you.

  9. Brittany July 8, 2015 at 3:28 am #

    Hello Dr. Ben and/or Dr. Aron. I have had 2 miscarriages within the last 2 years and have one copy of the A1298C gene. My question is whether I should start taking baby aspirin in preparation for my next pregnancy and ongoing once pregnant and if I should seek someone to prescribe heparin once pregnant as well since I’ve had RPLs. My ob doesn’t feel my mutation is too much of a factor, but my holistic doctor who has done more bloodwork than my ob seems to think it could be key to my losses. I also have hypothyroidism which has been well controlled during both losses. I’m torn on what to do and where to start once we try again. I would appreciate any input from you…I know my ob values other Doctors who know more about certain conditions and truly believe if I have compelling information from such doctors he will help to make my next pregnancy successful if possible.

    • Dr. Aron July 20, 2015 at 9:09 pm #

      Hi Brittany – There have been some positive studies for baby aspirin to prevent miscarriages, but it doesn’t seem to carry over to women who’ve had more than 1 or 2 miscarriages in the past. So the answer to that is…it may or maybe not help. However, since your OB is open to discussion, I would discuss Dr. Ben’s article on prenatal supplementation with her. Other women have had positive results with this protocol. You can find the article here: Much of fertility comes down to the health of both parents and proper nutrition. Wishing you all the best! Please keep us updated on how it goes!

  10. Zara October 4, 2015 at 11:54 am #

    I am 27 and waiting my test after IVF procedure. I have one miscarriage. Ihave homozygous genotype for c667t MTHFR and i was prescribed only fraxiparin without baby aspirin. Do you think, D-r Ben, that this is enough? I am also heterozygous for PAI 4g / 5g.

    • Dr. Aron October 5, 2015 at 4:41 am #

      Zara – This article on Prenatal Supplementation should give you a good idea of what Dr. Lynch generally recommends.

    • Casey March 9, 2017 at 11:34 am #

      Hi Zara – I realize this post is old, just wondering what your experience has been. Just diagnosed with homozygous C667T and PAI 4g/5g.

      • Zara April 25, 2017 at 8:56 pm #

        Hi i was only on fraxiparin no aspirin was prescribed during my pregnancy. Later during my pregnancy aspirin was added for a short time.

  11. Zara October 5, 2015 at 3:33 pm #

    Dear d-r Aron, i have read this article. There is nothihg in it about baby aspirin and my question was about baby aspirin when i am on fraxiparin. Best regards, Zara

  12. Ryanne October 5, 2015 at 5:55 pm #

    Hi Dr Ben and/or Dr Aron,

    I have been trying to conceive for about 4 years now, and was diagnosed heterozygous C677T MTHFR as well as heterozygous Factor V Leiden after 2 early losses (6-7 weeks but the pregnancies were not developed to 6-7 weeks). I was on baby aspirin as a precaution before/during my second loss, and I was prescribed Folgard but I chose to take a different supplement. I am taking the following: food source multivitamin with methylated B6/B12/Folate, methylated B6/B12/Folate supplement, baby aspirin, fermented cod liver oil (1000mg/day). I am told by my OBGYN that for future pregnancies, they will not start lovenox until the pregnancy is confirmed via ultrasound and they see a heartbeat. However, my instinct is that I should be on the lovenox prior to implantation, since my losses happened so early. What is your opinion on that? Also, can MTHFR and FVL inhibit implantation in addition to causing problems with an embryo that has successfully implanted? I’m curious because in addition to the miscarriages, it is taking approximately 18 months to get pregnant at all.

    Thank you!

  13. Cait October 30, 2015 at 5:30 pm #

    Hello, I have just been diagnosed with homozygous A1298c mutation. In 2015 I delivered twins at 20 weeks, and a singleton at 16 weeks 9 months later, both due to placental abruptions. I have one living 5 year old, who had a normal pregnancy ending at 39 weeks due to rupture of membrane, 7lb, 11oz, she has Asthma, but no other health issues. I am 30, my husband is 37, both are heathy. We have been given our diagnosis, but no plan yet. I am curious to hear others with similar losses and what the protocol was for next pregnancies.

    • Dr. Aron October 30, 2015 at 5:52 pm #

      Cait – Sorry to hear about your struggles with pregnancy. You are not alone in this and there’s a lot that can be done. Please see this article on Prenatal Supplementation. This should give you a framework that has helped other women in your situation. Wishing you the best!

  14. Ruthanna Johnson December 8, 2015 at 10:15 pm #

    I asked my repo endo about the MTHFR gene mutation today and he said “it has been disproven” ? We have had 3 blighted ovum pregnancies in a row after 1 healthy living child with no complications during pregnancy. Have done all the chromosomal testing, checked my egg supply and function of tubes/uterus as well as the hormone level panels they do. All of this is normal. He said baby aspirin, folic acid and then progesterone when we get pregnant. Seems like no answer and a quick brush would you reply to his statement Dr. Ben?

  15. Edit January 10, 2016 at 2:54 am #

    Hi, after 3 miscarriges I found a doctor, who tested me “for everything” (there are items on your above list, that were not checked) and it turned out that I have compound heterozigotus MTHFR mutation. At my 4th pregnancy I received two times ivig infusion + the medication was the following: 0,6 Clexane, Aspirin Protect, Femibion (prenatal containing both folic acid and metilfolate), C500, E400, cink, selenium, Magnerot 3*2.
    Now I have three children, all were born between 35 and 37 weeks probably due to streptococcus infection. I had issues with low platelet count (from half of all my pregnancies it was below 150, and it was around 120 at time of their birth) and high blood pressure in third trimester at my third child.
    I am seeking the reasons, what should be modified at a possible fourth time. Was it because of the prenatal (it contains only 200 mcg metafolin) or clexane is not good for me (because of platelet count)?

  16. chouchette January 22, 2016 at 10:01 am #


    I have been going through an ivf cycle with egg donation. After two implantation failures we found out that I have Hashimoto desease, with very high anti thyroids antibodies, so for the third transfert of 2 blastocysts I was given daily 20 mg of prednisolone, but my blood test still came negative. Before starting a new cycle of ivf with ed, I have done other test and we found out that I have an mthfr heterozigout mutation c677t. so for the last transfert I was given prednisolone, baby aspirine, vitamins B1, B6 & B12 and folic acid (not the active form). I was pregnant just to miscarry at 7 weeks. I don’t know what to think about all this, I want to go through a new cycle but what do u think should me changed, do you think I should take heparin next time?
    I want to add that when I was pregnant, before miscarrying, I was had a trophoblast abruption with bleeiding….
    I am desperate and really need your advice,
    many many thanks

  17. Kathy February 25, 2016 at 5:38 am #

    Hello.. I am trying to locate an article my daughter and I read last year regarding Lovenox and MTHFR, (Not using it).
    My brother, sister , 3 nephews, 2 nieces, 1 daughter and 1 grandson have all been tested for MTHFR, we all have the same double mutation, C667T. One nephew, and two of my own children, and 6 other grandchildren have yet to be treated.
    I have a myriad of health issues to boot, including hypothyroidism, Hashimoto, am a warafin lifer after 5 events with clots. I am having knee replacement surgery in two weeks.
    My hematologist would love to see proof that I am not to use the lovenox. I won’t take it anyway. (I stay in the hospital 2 extra days on IV heparin.) But she wants the information.
    Can someone help me?

  18. Rachel March 10, 2016 at 10:00 pm #

    My husband and I have recently been diagnosed as MTHFR – I am a carrier for 1298C hetero and he is positive for both 677 hetero and 1298 hetero. This will be my first pregnancy. He has three healthy children from a previous marriage, after which he had a vasectomy. He went through ICSI and then we did IVF. I had one embryo implanted and eight frozen. After getting a positive and finding out we were pregnant, we then learned it wasn’t meant to be, ending in miscarriage. This led us to decide on genetic testing for the embryos and a blood test for each of us to help with that. That gave us our diagnosis. So here’s where I am: My RE has ordered Metanx for me and I have stopped taking my prenatal with folic acid. I’ll take my Metanx with DHA and CoQ10, as well as a baby aspirin. The nurse told me all would be fine if I took these and then we implanted an embryo. But if the embryo already has the genetic mutation passed on, even the medications I am taking would not help, correct? Will we have to do an entire new round having been on the medications through IVF to have a healthy baby?
    Thank you for any light you can give!!!

    • Dr. Aron March 12, 2016 at 7:29 pm #

      Rachel – The purpose of the Metanx is not to correct the MTHFR SNPs. These MTHFR SNPs (single nucleotide polymorphisms) are variants, which means that the enzyme that results in methylfolate (an active form of folate) is slowed or has reduced activity. Taking the Metanx supplements the methylfolate that your body may have trouble producing on its own. I can’t speak to the IVF process itself, but the goal of supplementing with Metanx (along with a healthy diet and lifestyle) is to minimize the risk of future miscarriages. Hope this helps.

  19. Diana March 16, 2016 at 4:08 pm #

    Hello again!
    So here goes my story again. 4 miscarriages. 2 missed misacarriages and 2 biochemical pregnancies. After first missed miscarriage I was diagnosed with MTHFR C677T and PAI-1 heterozygous mutations…doctord didnt think that was cause of my loss but kept searching and found out your side and kept learning. I started supplementing by oyur procotol and 6 months after my 1st loss i had faint line on pregancy test, all symptoms were here , I was pregnant but my period started few days after BFP. After that my ob gyn told me to take low dose of aspirine every day and when we get another positive that they will put me on heparine. Another 6 months passed another BFP and another chemical pregnancy…this time my all they did was checked my hormone levels and everything came back fine…and was pregnent withing 3 months. I was doing folate and other supplement protocol, baby aspirin…at 6 weeks they checked my glucose level which was slithly high and i was put on diet, which was not new all i restriced was all sugar cause my diet was good by then,…TSH hormone levels suddenly also rised and they gave me euthyrox pill which did good job, from the begining i was onprogesterone supplements as well…also at week 7 they made me stop aspirin and instead i was put on clexane (heparine) injections…my immunology tests i did while I was pregnant and using aspirin came back normal which made me think that they arent really accurate.everything seemd fine, baby was developing, we had positive fetal rate at week 8…and then at 11 weeks we found out it happened again…baby stopped developing at 10 weeks…that was 10 days ago…i am still devastated with million questions about what went wrong this time… we are waiting for our kariotype mapping analyse. Unfortunatley they didnt do cytogenetic analyse of our baby so we wont have that answer…I am very scared to even think about another pregnancy…I know i might never find the answer about what is causing this but also I find it hard to believe doctors and their procedures…Dr. Lynch do you have any suggestions?
    Thank you!

  20. CG September 2, 2016 at 2:51 am #

    Dr. Lynch,
    I recently found out I’m pregnant. On 8/29/16 my HCG was 139 & progesterone 25. On 8/31/16 my HCG was 171 and progesterone dropped to 18. I’m homozygous a1298c and have had 3 miscarriages between 5-7 1/2 weeks. I’m currently taking baby aspirin which I didn’t before. I’m about 4 1/2 weeks along now. What do you recommend I do to make this a successful pregnancy ? Is the drop in progesterone a concern? I’m currently waiting on my prothrombin test and “Reoccurring miscarriage” blood clotting panel to come back. I didn’t know I was MTHFR when I was pregnant with my daughter and I had no problems getting pregnant or staying pregnant then. Ever since then , I have been trying for 4 1/2 years now for #2.
    Also, what’s the difference between taking Neevo DHA and Seeking Health Optimal prenatals? I’m new at MTHFR and I’m so confused.

    • Dr Lynch September 3, 2016 at 5:53 pm #

      Hi CG –

      Sorry to hear about your losses.

      Great to see you here and taking preventative action and working hard to optimize your pregnancy! 🙂

      Please read this article:

      The difference between NeevoDHA and Optimal Prenatal is the science for one and the ingredients for two. Optimal Prenatal is comprehensive where NeevoDHA has a few supportive ingredients. During pregnancy, one needs comprehensive support. This is why I formulated Optimal Prenatal. I wish it was around when my wife was pregnant. Thankfully our boys are healthy – but they could’ve possibly been even healthier.

      I highly recommend the Optimal Prenatal Protein Powder as it is more comprehensive and easier to take. The Vanilla is my favorite. It is actually what I take most mornings for breakfast. Seriously.

      Have a great pregnancy!

  21. CG September 2, 2016 at 3:10 am #

    Sorry, correction. My HCG on 8/31 was 271

  22. Jamie January 20, 2017 at 3:52 pm #

    I am 39 and was just diagnosed with homozygous C677T defect. I had my first miscarriage at age 22, and 6 more losses within the 9 years after that. I have several health issues, including brain atrophy, balance disorder, autoimmune disorders, chronic protein in my urine, peripheral neuropathy, arthritis/sever widespread inflammation, ibs, anxiety, chronic depression, alcoholism (recovered), etc. None of these conditions respond to meds, so my psych doctor ran this psychotropic gene test and this is what we got with the results. Anyway, since I was/am single and had psych issues, no doctor was interested in testing for the reason for the multiple miscarriages. I did my own research and blog reading, and came across the suggestion to take baby aspirin. During my last pregnancy, I randomly just treated myself with the aspirin and today I have a 9 year old daughter. She has some issues, such as alleries, asthma, anxiety, ibs, but other than that she seems normal and smart. Since I just found out about this gene defect, I am trying to be proactive with her diet and health, but am having much difficulty finding a doctor to take me seriously. I really don’t want her to suffer all the physical damage and the heartache from losses as I did. I hope more doctors take up studies in this and sooner rather than later!

  23. LSS March 27, 2017 at 6:55 pm #

    Through recent blood work, it was determined that I have slightly raised cardiolipin IgM (15 MPL unit/mL in December and 14 MPL 12 weeks later) as well as single mutation C677T heterozygous. My ob/gyn said if I get pregnant again (I’ve had 2 miscarriages in the last 7 months), I’ll have to take Aspirin in my first trimester and Lovenox for the other 2 trimesters. I’m in the process of being referred to a Hematologist because my mother’s parents both have the MTHFR mutation, and many of my mother’s siblings have this too. I’m wondering what I should be doing now to prepare my body for another pregnancy, if I do decide to try again. Should I be taking Folate or Folic Acid? Prenatal vitamins? Aspirin? Fish Oil?


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    […] to process folate, this can result in a build up of folate in the blood and cells that has been linked to multiple miscarriage, also known as recurrent pregnancy loss.  To make matters worse, the current clinical guidelines […]

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MTHFR and Methylation Presentation – PDF Version

Many physicians have requested copies of various slides from my MTHFR and Methylation Presentation. I have accomplished this finally.  ...