Why MTHFR is Becoming Recognized

For millenia, humans have walked the planet.

We’ve continued to evolve and develop as a species:

  • walking upright
  • less ‘fur’
  • learned farming and ranching
  • further understanding of how the world works
  • further understanding of how biochemistry works
  • transportation
  • communication
  • creating and developing new technologies
  • eliminating or seriously reducing common causes of death

In our on-going push for development, we’ve begun to get off track and in some ways – seriously.

  • Food is no longer food.
  • Water is no longer water.
  • Air is no longer air.
  • Soil is no longer soil.
  • Animals are no longer animals.
  • Bugs are super bugs.
  • Medicine suppresses – not heals.
  • Not everything naturally decomposes.
  • Electromagnetic radiation permeates us from all directions constantly.

What do all these have in common?
Toxicity and Xenobiotic Exposure.

When you add up the effects from the list, it is readily apparent how toxic and loaded our bodies are.

How does our body eliminate toxins, stress hormones, histamine and xenobiotics?

How do we support methylation?

  • Healthy, whole food prepared properly
  • Organic vegetables and fruit – really organic (not middle of the night diluted organic standards for big corporations)
  • Leading lives of healthy thoughts and interactions
  • Sleeping well
  • Eliminating and defecating twice or more daily
  • Exercising
  • Pure water
  • Avoidance of toxins, xenobiotics, stress, chemicals, artificial anything.

Are you supporting methylation?
Take a step back. Are you supporting methylation?

Are you trying to support methylation but finding it extremely difficult because you are:

  • Working 40+ hrs a week with only 2 weeks of vacation a year (if that)
  • Eating on the run
  • Stressed
  • Commute to work inhaling toxins and exhaust
  • Sit inside inhaling countless chemicals and solvents
  • Eating processed foods
  • Eating genetically modified foods – including wheat (altered to have more Gluten)
  • Cooking with a microwave
  • Drinking soda, juice, bottled water or unfiltered water
  • Eating, drinking, cooking or storing foods in plastic, teflon, non-stick, aluminum
  • Not exercising
  • Not sleeping well or not enough
  • Taking various medications
  • A parent dealing with your children
  • A child dealing with your aged parents
  • An individual caring for someone ill

Combine the factors which support methylation against the ones that antagonize it.
Do you find that you support methylation more than not? If so, you should be quite healthy.

Do you find that you antagonize methylation? If so, you should be quite ill or getting there.

Why has the MTHFR gene mutation become an issue worth understanding?
Methylation is severely lacking due to lifestyle, dietary and environmental exposures.

DIS-ease and dysfunction are present if the body cannot obtain, process and utilize the nutrients it needs to in order to support methylation.

If you add genetic polymorphisms to the already apparent lack of methylation, disease and dysfunction are going to be amplified.

This is why the MTHFR polymorphism is coming to a head.

MTHFR is at the CENTER of methylation – literally.

If a MTHFR defect exists, then methylation is slowed immensely.

A scientific paper on this matter identifies the methylation issue well:
The metabolism of methyl-consuming compounds generates reactive oxygen species and consumes labile methyl groups; therefore, a chronic increase in the levels of methyl-consuming compounds in the body can induce not only oxidative stress and subsequent tissue injury, but also methyl-group pool depletion and subsequent aberrant methylation status. In the past few decades, the intake amount of methyl-consuming compounds has substantially increased primarily due to pollution, food additives, niacin fortification and high meat consumption. Thus, increased methyl consumers might have a causal role in the development and prevalence of metabolic syndrome and its related diseases. Moreover, factors that decrease the elimination/metabolism of methyl-consuming compounds and other xenobiotics (for example, sweat gland inactivity and decreased liver function) or increase the generation of endogenous methyl-consuming compounds (for example, mental stress-induced increase in catecholamine release) may accelerate the progression of metabolic syndrome. Based on current nutrition knowledge and the available evidence from epidemiological, ecological, clinical and laboratory studies on metabolic syndrome and its related diseases, this review outlines the relationship between methyl supply-consumption imbalance and metabolic syndrome, and proposes a novel mechanism for the pathogenesis and prevalence of metabolic syndrome and its related diseases.[1]

 Take Home Points on Methylation:

  1. Address the things in your life that are depleting your ability to support methylation.
  2. Continually improve the activities in your life that are increasing your ability to methylate.
  3. Identify genetic defects which alter methylation and assist in the restoration or bypassing of these defects

Write your thoughts below by leaving a comment.

11 Responses to “Why MTHFR is Becoming Recognized”

  1. Melissa March 17, 2012 at 2:58 am # Reply

    It absolutely amazes me that my daughter’s journey has come full circle to end up here. I originally thought her eczema/hives was histadelia and then I realized that it could be related to this gene malformation that was presented to me as no big deal, that could maybe be the reason for my sister’s six miscarriages and the higher risk for me. I am so happy to have made the connection to our issues and to have found your site. You have truly given me hope to find the light at the end of the tunnel! I really appreciate your passion and information on this topic. I do have one question…our recent focus has been on a water source. Our daughter seems to have issues with flouride and the only water without it is reverse osmosis and that is what we are using, but are afraid of leaching. Is there a better option for water? I found a Nikken filter that makes water more alkaline since RO is acidic and our little one tends to lean on the acid side. What do you drink? Thanks again!

  2. Cathy March 17, 2012 at 3:34 am # Reply

    I feel lost. I am suppose to be getting clots and PEs because of MTHFR. One copy of the C and A problematic gene but maybe regular homocystine levels. I have peculiar leg pain– be is from my back or Neuro. No physician has suggested any possible treatment. I am on warfarin and have filter in my 54 year old body. Started at 46, but maybe earlier. Extreme back pain with disc degenerative disease. Herniations make my legs the lessor evil. I worry if there is a connection to past endometriosis problem, certainly my miscarriage— maybe Parkinson’s. Just not sure what symptoms are about MTHFR. Anyone at Yale??

  3. Elizabeth Sellars May 7, 2012 at 5:38 am # Reply

    First and foremost,I want to thank you for all of this work you are doing with this condition. I had two near term pregnancy loses and a second trimester miscarriage before being diagnosed as having a double strand of this “rare” disorder. I now have three children who are all diagnosed as being autistic on various ends of the spectrum. I have been trying to find out if my children need to be tested, but when I bring up this term no one, and I mean no one knows even what I am talking about. I have to wonder if there is a connection from this condition to my children having autism.

    I was on metformin for years after developing gestational diabetes with my oldest daughter. I was also prescribed lovanox,baby aspirin and of course folic acid. I was told that this condition was only worrisome during child bearing years. I am 39 and have since had a hysterectomy from fibroids and cysts on both my uterus and ovaries. I have suffered severe depression, anxiety and fogginess for years. I associated it with the loss of my other children. As more information becomes available I began to understand that I was not only depressed from those loses, but that I was prone to have it.

    I have been diagnosed as having “thick blood” which means I do not bleed much if at all when cut, I do not bruise as a normal person would. It takes one heck of a wallop to leave a mark. I have extremely high cholesterol, high blood pressure, borderline diabetes and as I mentioned depression and anxiety.

    At a recent mental health appointment, I was told about Cerefolin and asked if I was on it. I was not, but had been trying to supplement myself with Folic Acid, B12 and B6. From your explanation I understand that Cerefolin is good? Or is it not? These terms even in your more common explanations still confuse me horribly.

    Do I have my children tested as my husband’s father is a carrier and I have a double strand? I need help, guidance and to most of all understand what this condition is that I am so lucky to have inherited from both parents and is being made worse by the world we live in.

    • Dr Ben May 7, 2012 at 5:49 am # Reply

      Hi Elizabeth –

      Yes – you should have your children tested. Cerefolin is pretty good – yes. You should not be taking high doses of folic acid – rather methylfolate and perhaps also folinic acid if needed.

      Please do watch this MTHFR video.

      I am happy to help you one-on-one if needed. Please do know I am available for consultations on a limited basis. You may call 800-547-9812 to schedule a consult anytime.

      • Elizabeth Sellars May 7, 2012 at 6:55 am # Reply

        Thank you so much. I will watch the video and hope that its not above my comprehension. I wanted to ask this one last thing because I am confused about this. I understand that this affects amino acids as well. Does this mean we have too many amino acids in our system or that we should be taking amino acids as a supplement? I really appreciate all of you help and time. I will call the number as soon as I am able and have watched the video. Again thank you.

  4. Danelle February 15, 2014 at 4:26 am # Reply

    Is it harmful to start taking Methylfolate while pregnant? I just found out that I have 2 copies of the MTHFR C677T mutation and I am pregnant.

  5. Summer April 7, 2014 at 10:55 pm # Reply

    Not sure if this is the right post to ask this question; I’ve heard the MTHFR mutation can cause clotting by interrupting blood thinning? Is that correct? If so does this explain why I have very heavy periods with lots of large clots? Will treating correct this?

  6. Carrie May 27, 2014 at 12:46 pm # Reply

    I have 2 children one at the age of 20 – great pregnancy other than preeclampsia and then when I tried to conceive started the miscarriages 4 sweet angels, then it was discovered that I have double strand MTHFR… I was put on Prenatal Vitamins, Folbic, Daily aspirin, and Lovenox injections daily – I have a VERY HEALTHY little boy now who I call my little miracle.

    I have this I have been told that I am at risk for blood clots (found that out when I wanted to go on birth control). My question is NOW what do I need to worry about – I am 39 this October and I am overweight. Please help me learn what I can to prevent any other issues from this mutation. What other causes or issues can this mutation cause. I thought it was only a worry when I was pregnant but now I am not so sure.

    Thank you –

    • Dr Lynch May 28, 2014 at 4:05 am # Reply

      Hi Carrie –

      It’s important to be proactive all throughout your life – and your child’s life as well as they have MTHFR as well.

      Pleased to hear about your healthy boy ;)

  7. Carrie December 28, 2014 at 1:10 pm # Reply

    I have a question my daughter who will be 19 is a double strand carrier. My son who is now going to be 2 yr and 7 months soon has not been tested but is chronically ill. The doctors have sent is to an infectious disease doctor with everything checking out normal there. What issue or where can I find them in the internet could this double strand have onmy son if he is a carrier? Please ANY help is appreciated. He is sick every 2-3 weeks since he has been 6 months old – I just want him better. B

    Thank you in advance –


  1. Endometriosis and MTHFR: A Connection | | MTHFR.NetMTHFR.Net - March 24, 2012

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