MTHFR Test Options? Oral Swab, Blood Test or Saliva

Now that MTHFR is gaining awareness, more options for testing are popping up.

The best option is to have your healthcare professional test you for MTHFR.


It is the easiest and fastest and – more importantly – it may be covered by your insurance.

If your healthcare professional will not do the MTHFR Test, then there are three options for you that I trust.

The three options I recommend for the MTHFR Test are:

1. Spectracell Labs MTHFR Test

  • Sample: Blood
  • Blood draw needed
  • Turnaround time: typically 1-2 weeks depending on results delivery method (general mail or electronic)
  • Price: $140 or so
  • Tests for MTHFR A1298C and MTHFR C677T
  • International availability. USA customers have prepaid return shipping label. Overseas customers must pay for self for return shipping.
  • Find a physician to order MTHFR Test by Spectracell here


2. Molecular Testing Labs MTHFR Test

  • Sample: Cheek Swab
  • NO Blood draw needed
  • Turnaround time:  3 to 5 days
  • Price: $199 or so
  • Tests for MTHFR A1298C and MTHFR C677T
  • International availability
  • Find a physician to order Molecular Testing Labs MTHFR Test here


3. 23andMe Test

  • Sample: Saliva and Cheek Swab (for infants and young children)
  • NO Blood draw needed
  • Turnaround time: 6 to 8 weeks but may take longer due to volume
  • Price: $199 for first test and 10% discount for additional tests (As of March 2016)
  • Tests for MTHFR A1298C and MTHFR C677T and various other MTHFR snps PLUS numerous other genetic polymorphisms
  • International availability for many countries
  • Order the 23andMe Test here

How to get the 23andMe Test to show genetic information:

When your results come in for the 23andMe test, you will not find the MTHFR listed. You will have to download your ‘raw data file’ and run it through one a genetic reporting service:

StrateGene: this report provides not only MTHFR but also key other genetic polymorphisms which are clinically relevant.

Which test is the best option?

23andMe with StrateGene.


Simply put, there are more genes than the MTHFR gene in the human body.

Identifying the MTHFR polymorphism is important – absolutely. However, identifying, and addressing, additional genetic polymorphisms is even more important.

If you need to know right away if you have MTHFR, then the best option is to order the MTHFR test through your healthcare professional.

Ethical considerations:
Ordering the MTHFR test does not have really any ethical considerations. It simply looks at a couple variations in the MTHFR gene and reports those two back to you.

Of course, one may be shocked and alarmed when finding they have the MTHFR defect; however, after reading the various articles here on MTHFR.Net, one should immediately begin to understand that having the MTHFR mutation is not something to be alarmed about – rather it is something to address and begin improving your lifestyle for the better.

When ordering the 23andMe test, this definitely has some ethical considerations as it provides findings in many genes – including BRCA (breast cancer risk) and APOE (Alzheimer’s Risk). The beautiful thing, though, when ordering the 23andMe Test is that you are able to begin addressing the genetic issues – and discovering possibly why you are experiencing various symptoms.

I can tell you right now – that once you get your report from StrateGene, you will be initially overwhelmed – and so will your doctor when you plop that report on their desk.

Currently, I am working hard on making a training course for physicians – and the general public – which will help guide treatment plans.

The best course to take first is ‘Applying Genetics in Pediatrics.’ While this course is focused on kids, it is applicable to all ages and is a great starting point. It is suitable for both layperson and health professional.

129 Responses to “MTHFR Test Options? Oral Swab, Blood Test or Saliva”

  1. Evin January 8, 2014 at 4:01 pm #

    I just ran raw results through the MTHFR Support test you advocated for above and am disappointed. You wrote, “This report is broken down into various categories. I have provided MTHFR Support some of the findings from my research which they have added to their report.” I guess this implied to me that there would be some information from your research about why genes were included. All my report included was links to which gives very little information. So, I paid $20 for a lot of information which makes no sense to me. I *really* wanted to know why the tongue tie genes were included–tongue tie in our little one is the whole reason I started down this path…Genetic Genie at least explained why the gene was important and gave enough information I can begin some research and understanding. After reading this website and waiting two months for our 23 and me results so that I could see our little one’s tongue tie information I am really disappointed and feel misled.

    • Dr Lynch January 8, 2014 at 7:02 pm #

      Evin –

      As you know, the FDA cracked down on 23andMe for providing information relating to Health Traits. When a report comes out stating what a gene polymorphism may or may not do, it is doing exactly what got 23andMe in trouble in the first place.

      Yes, we want to know exactly what these genes do but it is way more than genes.

      Please read this article on DNA Testing.

      I will write another article soon on how to research various gene polymorphisms on your own.

      Quickly, when you find a gene polymorphism on your report having the homozygous risk allele, plug in that specific rsid into Google Scholar. There you will discover various research.

  2. Michele Zimmer January 23, 2014 at 5:41 pm #

    People should be aware that 23andMe has changed their testing. You can get your raw data still but it is not as complete as it once was. They changed their processing from a 59 SNP chip to a 41 SNP chip. This means they are not reporting back as many SNPs as they used to (59 vs 41). This means your data when processed by MTHFR support will not be as complete. You will be lacking the data for MTRR H595Y, BHMT-04, AHCY-02, CBS N212N, and SHMT1 C1420T. My family purchased the tests. My husband was processed on the 59 SNP chip and my son and I were processed on the 41 SNP chip. Now it is harder for my doctor to determine my son’s and my protocol since data is missing. I really don’t want to go and spend more money on testing. So buyers beware, 23andMe is NOT what is used to be (raw-data wise).

    • Carol June 16, 2014 at 3:38 pm #

      Dear Michele,
      My husband and I recently received our raw data from 23andme. Once I uploaded the SNPs to Genetic Genie, our methylation analysis results came back with all of the ones you listed as ‘not there anymore.’ Please try again and see what the results are.

  3. Fran January 24, 2014 at 5:58 pm #

    I followed the 23andme link. Apparently, as of Nov. 2013, this company cannot provide health related testing/reports for new customers. Heres the page I read.

    Is there an alternate place that will give multiple test results?

  4. Dr Rhonda Simons February 18, 2014 at 3:13 am #

    I use HDL (Health Diagnostic Labs)labs. This is FREE for all patients who have any private insurance. It is blood testing for 677 & 1298, as well as Apo E, and advanced lipoproteins, and inflammatory molecules–hs-CRP, fibrinogen, MPO, and Lp-PLA2….I also use Singulex for other inflammatory molecules: TNF-alpha, IL-6, IL-17…ALL of that testing is FREE to patients, as they take what insurance will pay, and never remainder bill.

    I also use Genozyme/Genomind testing which uses saliva. Also FREE to patients with private insurance. Presently only the 677; however 1297 due in the fall, as well as 19 other cool genes! They also do serotonin transporters and receptors and dopamine transporters and receptors, as well as the different Cytochrome P450 pathways: C19, 2D6, etc…this lets you know if patients are metabolizing through certain pathways too slowly (increased side effects, toxicity), or too fast (gets out of system too fast so it “doesn’t work”–then some docs tend to increase dose which can be harmful.
    Okay to e-mail me at if you would like to have contact info for the reps for those labs so you can offer them.

    • jimmy February 13, 2017 at 9:05 pm #

      how can I get these test done?

  5. Nicole February 26, 2014 at 5:15 pm #

    I’m wondering why you’re still recommending 23andme when they don’t test for MTHFR. Makes it hard to trust any of your recommendations.

    • Dr Lynch March 1, 2014 at 7:14 pm #

      Nicole – 23andMe does test for MTHFR. I explain it fully how it works in this article.

  6. Larisa February 27, 2014 at 1:10 am #


    Which one should I trust more blood test or saliva 23andme test?

    Im hoping to get some guidance about some conflicting genetic info Im getting. My doctor ordered a MTHFR test back in october, the results were homozygous for 1298 and normal for 677.
    I ordered a 23andme test a few weeks ago to uncover any other mutations that need to be addressed. I uploaded my results to and to sterlings app they put me at compound hetero for both 1298 and 677.

    I know you are really busy, but if you could please respond, I would really appreciate it.
    It will greatly inform my protocol, I want to be informed as possible.

    • Dr Lynch March 1, 2014 at 7:20 pm #

      Larisa – need to contact the doctor and let him know. One lab is wrong and need to find out which one.

      • Jeanette April 18, 2017 at 9:28 pm #

        Larisa/Dr. Lynch
        I sure would be interested in knowing which of these tests was wrong.

    • Melissa Adams September 16, 2018 at 8:19 pm #

      I had the same thing happen. A blood test through a very respected lab in Germany says I have 1 copy of the 677 allele & 2 copies of the 1298, but my 23andme sample results say 2 of the 1298 and NO 677. (Annoying as assuming 23andme must be incorrect – which makes any methylation health info I get with that data suspect.). Any advice?

  7. terri March 13, 2014 at 10:49 am #

    Since23 and me went under FDA scrutiny, does anyone have a NEW list of SNPs they test? I have a bad feeling about them but still trying to decide between Yasko & 23 and me. (Already know my mthfr &will know CBS soon…need other SNPs)

  8. Betsy Fiel March 17, 2014 at 5:35 pm #

    23 and me site states “at this time we do not offer health-related genetic reports”. I assume this means to select another type of testing option, is this correct?

    • Dr Lynch March 18, 2014 at 5:36 am #

      23andMe is still taking test samples – and you still can receive your raw data.

  9. Laura Foster March 24, 2014 at 5:37 pm #

    Dear Dr. Lynch, after having two sons, I believe I began to have 2D6 issues and will vomit drugs in that class, and was hospitalized twice after consuming sulfites. I then had 2 years pass and suffered from acetylcholinesterase inhibition due to being sprayed in an overspray with Dursban (an organophosphate pesticide) actually “chlorpyrifos.” I became unable to tolerate any items one would call “toxins,” pesticides (including all forms) most foods, perfumes, chlorine and anything such as floor waxes made from petrochemicals. At one time I was found to be “allergic” to all but two foods. I had a genetic test prior to that and found I have a genetic predisposition for hypercoagualable blood and fibrinogin deposition. I used to take a blood thinner and some supplements to address those issues. Four years ago I was told I have cardiomyopathy following hospitalization for low sodium (followed by a seizure for which I now take clonazapam), and cardiac enzymes prompting an angiogram. My husband died 8 months ago and I am disabled and alone. I wonder if you would speak with me online or on the phone about what I should do now. I am reading the two ways to test and wonder which way to go. My relative (my cousin’s daughter on my father’s side) told me about your work. I need to be able to take care of myself and that includes being near toxic chemicals, near airplane exhaust, car exhaust, etc. Now I am an older, single woman with heart failure and detox issues. I have post-exertional fatigue and was dx with CFS at Johns Hopkins due to disautonomia in 95, so I need to get well due to having no support system in place. Most doctors have no idea what might be wrong with me, so I have been fortunate to get care at all. I live in the Dallas area and am tired of Dr. Rea’s clinic due to high costs and low/slow return on investment and continuous use of shots and detoxing in sauna. My email is above. I can be reached at 817-296-1883. I purchased the phone for a call from Dr. Lynch so any attempt from readers to misuse the phone number will be fruitless. I have an urgent need to be self-reliant. (PS Quackwatch is just a chemical industry front group). All the best, Laura Foster

  10. Loribeth March 27, 2014 at 6:19 pm #

    I would love to get in touch with the Becky that posted on October 1, 2013 at 1:03 am…
    I am very interested in more info on the “8 day liquid diet cleanse from Heavenly Herbs” and cannot track down a company by that name with a product like that. If you read this will you please post a URL or phone number or even the city, state, country of the Heavenly Herbs company that you used. Thanks in advance!

    • truly May 22, 2014 at 11:42 pm #

      I would like to know that too!

  11. Angie April 11, 2014 at 10:07 pm #


    I am new to this all and desparate for answers. I am one complex case here or at least i feel. Hope this is not too long so here goes! My diagnoses in my life include Major Depressive D/O which is treatment resistant, Binge Eating Disorder, Sleep Eating Disorder from which I sleep walk and eat in my sleep, IBS, Asthma, Vaginismus or Vulvodynia. I have tried A LOT of antidepressants and I am historically either very sensitive or they do not work after a trial. I have two sisters with whom this is also the case. Well I have recently tried taking Deplin and have experienced some good and bad side effects. My mood is like night and day. I know this is not the placebo effect as I have had two trials of Deplin from which had the same mental effect. the not so good effects are feeling like a zombie, stomach turning with no mental anxiety, feeling fatigued, difficulty waking up, eyes have been effected. I have quarted the dose of the 7.5mg of Deplin and the side effects have not gone away. I don’t know what to do. I do not want to be depressed but I do not want these physical side effects. It is such a tug of war. Another thing is that the Deplin at the 7.5mg dosage was helping me sleep through the night which is a very very rare thing for me. Another thing is that I am on 12.5mg of Topamax. don’t know whether to stop the Topamax and see how the Deplin reacts at a quartered dose or not. I feel so lost and like I am in a tug of war. I am having aches and pains too. However I recently last week got out of the hosptial for Pancreatitis as well so some of it could be that too. I feel like I am definitely onto somethign but do not know who to turn to as many docs have no idea what is going on with me. Any suggestions here! Sorry for the long paragraph. BTW I have also recently quit my job due to my depression and stress so I am very committed to getting mentally and emotionally stable. Thank you!

    • Terri April 12, 2014 at 5:00 am #

      Did you have your genes tested through 23 and me? MTHFR morphisms are linked to depression and so is COMT.

    • Kelly April 12, 2014 at 3:57 pm #

      Angie, I’m no expert but also have suffered many strange disorders including autoimmune with very complex symptoms and now am very versed in genetics as I’m also one of the lucky ones completely sequenced in the Harvard Personal Genome Project. I also did my exome and ran my whole family through 23andme, then ran everyone’s raw data through applications like “Genetic Genie”, “Nutrihacker” and “Sterling’s App” so I could see where the methylation pathways were causing or could potentially cause disease symptoms. In the end, this is what really matters. My husband has been battling Renal Cell Carcinoma for almost 5 years now and in all this time, we’ve now discovered the symptoms are really about methylation and nutrition. If your body can not breakdown the foods into the nutrition correctly, its going to create disease pathways rather than nutritive healthy ones like normal people… we have discovered this by taking the Q96 supplement that is methylated and nano-particled to penetrate the blood-brain barrier (documentary on Discovery Health explains), bypassing the genetic mutation pathways. Dr. Amy Yasko talks about this in her books. If you have mutated genes, say like MTHFR or MTRR for folate pathways, you will not methylate folate correctly which will screw up B12 and snowball other things… homocysteine levels, etc. I have folate metabolism pathways, estrogen pathways (do not take ANY birth control or hormones if you have mutated genes here!!)… anyway, the bottom line is an easy solution may be to try this particular supplement as it has already scientifically addressed all of these nutritive pathways. You can’t go wrong. Good luck dear, I know it sucks… Also, one question as I’m also on Topamax too (it is the only prescription drug I still take, why are on on such a strange dose? I take 200mg for migraine prevention and joint pain)? Feel free to message me privately if you’d like to talk more.

      • Angie April 19, 2014 at 5:59 pm #

        Hey Kelly:

        I would love to message you but I am so not computer savvy. HA

        Thank you for your email! I would love to correspond. In answer to your question, I am on low dose right now because I have a HUGE sensitivity to meds. Some landed me in the hospital, some the side effects were too great, etc etc. What I noticed about the Deplin although physically felt terrible mentally was like night and day. So I feel that I am on to something. The main thing is my sleep in which I sleep walk and eat and have little to no memory of it. It is so depressing! I am on birth control though. I have been on it for quite some time like a year or more. Well I went off of it and noticed that I felt horrible when I was off it and when I was back on it I felt much much better. So I am really looking into this 23andme stuff. Looks like it is worth it? I have spent so much money in figuring out stuff thus far. Have you found that your symptoms or your husband’s have gone away or significantly decreased since starting a correct supplementation regimen? Your email helps immensely because I know I am not alone in suffering. 🙂

      • Chrissa June 2, 2014 at 7:21 pm #

        Hi Kelly,
        I just read a response you wrote to Angie on April 12th, 2014 where you suggested she might contact you privately. How does one do this? I would love to contact you as I have Addison’s disease and my son has Hashimoto’s! We both have all kinds of other nonsense going on too and just recently my younger sister tested homozygous for 677T – I have yet to be tested but have always been more symptomatic then her and so I’m sure it will be yet another issue to deal with. Currently my biggest problem has been an inability to absorb calcium & magnesium & I feel like I am shriveling up from the lack of moisture. Actually the malabsorbtion of Calcium & Magnesium is a symptom of my inability to produce adequate potassium & salt… So do you think Yasko tests more thoroughly? Can you tell me more about the Q96 supplement & where to get it? Thx

    • Karen von Merveldt-Guevara April 13, 2014 at 4:43 am #

      Hello Angie,
      the symptoms you describe tie entirely in with high oxalate levels in your body. As you and both your sisters have the same symptoms you may share a genetic hyperoxaluria. To verify you should look into an Organic Acid Test in urine as available by Great Plains Lab – I will copy/paste a few links in here:
      …when you google low oxalate diet, you will come across several websites with recommendations… in addition there are parts of Klinghardt’s protocol in cooperation with Catherine Tamaro, who promote the use of K2-MK 4 (Menatetrenone) with Phosphorous to help reduce the effects of oxalates on the body (though there is controversy of how exactly K2 is doing its job). Out of my practice I can only say: “It works!” …the K2 protocol is on Page 44 – Good Luck! BTW I am a European MD who works in Alternative Healthcare (Integrated Bodywork combined with Orthomolecular Medicine in AZ)

  12. suzanne May 9, 2014 at 5:24 am #

    Heidi, I am in houston too, tested positive January 2014 at specracell labs thru a MTHFR knowlegable naturalpath, I am heterozygous C677T & A1298C. I no longer have an MD or prospect I would trust to have faith in and do not know of any MDs who may know much about this. my naturalpathic dr suits me just fine. My April bloodwork has improved since Dec. By taking some simple supplements and diet adjustment. Would be interested to hear your Houston care experience. -Suzanne

  13. Dr. Shabnam Das Kar June 9, 2014 at 2:26 pm #

    Thank you for all your input. I got your ref from the Thyroid Summit. Is testing for MTHFR rs 1801133 valid? I found a company which does only that & not A 1298C & C 677T. What is the difference?

  14. Florence June 16, 2014 at 5:52 pm #

    Does the ’23 and Me’ test show the HLA-DQ2 and the HLA-DQ8 for celiac? I so enjoyed the web class with you on thyroid. Not being a doctor, have heard of methylation, however was never sure what it actually did. So much clearer now. Thank you for a reply.

    • JJ August 23, 2014 at 11:29 pm #

      23andMe results include several SNPs that might predispose one to developing celiac. For example, rs2187668 (HLA-DQA1). I happen to have an A here, so I have this tendency, and have developed an autoimmune condition. I am doing much better on a gluten free/casein free diet.

      Promethease is another service that will analyze your raw 23andMe results although it is not for the faint of heart. Once you have uploaded your raw data and downloaded your HTML report, you can open it locally in your browser, click Show Everything, then do a find on a particular SNP like rs2187668. I would recommend not looking for a gene, as you may not find it in the text of this report.

      For the brave, you can also open your raw data file in any notepad-style editor and do a find that way, but you will need to do further online research via SNPedia or other sources to determine whether your particular alleles are significant.

      There are several SNPs listed for celiac in the SNPedia article:

      Livewello is another service similar to Genetic Genie, it lists many more genes related to methylation, detox, mitochondrial function, etc. but gives very little explanation. However this is how I found that I am heterozygous for both SLC19a1 and FOLR2 on Dr Ben’s Pathway Planner chart, which means I don’t process folic acid very well at all, and need to stay away from it. Dr Yasko’s supplements all contain folic acid (the synthetic form of folate), Dr Ben’s don’t (thank you Dr Ben!).

  15. Toco3 July 17, 2014 at 7:59 pm #

    It saddens me to read about this ‘Jennifer’. A person who is rude and ignorant, we all should just walk away. Please do not ‘stand there’ and answer every ignorant question/accusation she has.

  16. Bobette Kyle August 14, 2014 at 3:05 pm #

    FYI, 23andme seems to be caught up right now (August, 2014). I sent in kits for my daughter, grandson, and me. Daughter’s was done in less than two weeks. Grandson’s and mine will be complete in the next day or so, around three weeks total.

  17. james August 16, 2014 at 1:43 am #

    Makes you wonder about these tests….

  18. Sandie August 26, 2014 at 9:30 pm #

    I was just tested for what my doctor said are the two most common mutations of MTHFR. I’m confused, and honestly disappointed because I fit the profile. My daughter has a tongue tie, lip tie, and sacral dimple. I have a tongue tie, thyroid issues, chronic digestive issues (food allergies, heavy metals), and some other conditions listed. I have these issues despite doing all that I can to stay away from toxins and live a very healthy lifestyle.

    Do I need a more comprehensive MTHFR test to rule it out? If so, which one? Or should I move on to looking for another cause to my problems?

    • Sandie August 26, 2014 at 9:40 pm #

      Oops. My post wasn’t 100% clear– I tested negative for the two most common MTHFR mutations.

      • Sylvia November 18, 2014 at 6:19 am #

        Get a hard copy of your results. My doctor’s office called and said I was “fine” too. At my nutritionists request, I got a copy of my results. Turns out I am compound heterozygous for MTHFR. I will start treatment as soon as my 23andme results come in. If I hadn’t pursued it, I would still be in the dark.

  19. Kris August 28, 2014 at 6:41 pm #

    Hi Dr. Lynch!
    I was recently tested through Health Diagnostic Laboratory and came up as Intermediate Risk for MTHFR 677 & MTHFR 1298, does that mean I actually have both genes? I am having trouble understanding the results, its seems there are 3 categories, high risk, intermediate risk and optimal. For 677 I came up as C/T and for 1298 I came up as A/C.

    Not sure if you are familiar with that lab.

    The doctor that ordered the labs has been treating me for Lyme Disease. He advised me to take L-Methyl sublingual B12, 1000mg. Would you agree with him?

  20. Chaim Bochner September 18, 2014 at 9:20 pm #

    Hi Dr. Lynch,

    I ordered the 23andme, took the test, and after step 3 I get the message:

    Chaim, unfortunately we weren’t able to analyze your sample. There are no known steps that will increase your likelihood of receiving results from an additional analysis attempt. Find out more here.

    What are the chances of getting the second test processed? Also, it took me longer than half hour to collect saliva, is this maybe the reason for failure?

    I’m very concerned because I need to know the additional genetic mutations I might have.

    Please advise.

    Thank You,

    Chaim Bochner

  21. Karen Marciniak October 15, 2014 at 2:27 pm #

    I have been searching for alternative healthcare recently myself. Why? Because I have been prescribed several medications had multiple surgeries and I would rather find the root cause and prevent rather than treat health issues. My question is: Why don’t Medical Doctors suggest genetic testing when there are multiple disorders and common family health issues? I unfortunately think I know the answer to that. I will be tested this week for MTHFR. One of my adult children tested positive for it. We have had multiple cancer diagnosis in our family, many fatal. Personally I have had Peritonsillar abscess (tonsillectomy), extreme diverticulitis (colon resection of 8 inches), hypertension, constipation, gerd (taking omeprazole), repeat infections; respiratory and ear, now diagnosed with gallstones I have also had hernia surgery from all of the surgeries as I have had 9 surgeries thus far. ALSO I once had a chiropractor tell me after looking at xrays that I have evidence of Spinal Bifida.
    I am so sincerely thankful for my daughter who researched this for the sake of family and self and also so sincerely thankful to Dr. Lynch for his public service and caring attitude. He deserves to profit from it of course. I have shared MTHFR information with my faith based LinkedIn Group. There are over 4,000 members many of whom are medical and nutritional professionals. This is how I am trying to help get the word out.

    • Angie October 15, 2014 at 2:39 pm #

      A to the men Katen!!! It is really cost effective to get this testing done and costs less than the repeated meds they push out that don’t work. I feel ya!!

  22. Kath Platt October 16, 2014 at 9:11 pm #

    October 16th 2014 Rochdale Lancashire, England. Dear Dr. Ben Lynch My nutritionist suspects a methylation problem, can I be tested in England or send away for a test to America? I would chose the 23andMeTest. I eagerly await your response Thanks Kath.

  23. Pam October 25, 2014 at 8:02 am #

    I received my 23andme results. Who do I go to in Denver, Colorado to interpret and give me the proper protocol of supplements I need to get well?’

  24. Jen November 8, 2014 at 1:12 am #

    Can any of these tests be done on infants/babies?

  25. Mary D November 20, 2014 at 4:05 pm #

    Becky, please contact me. I need to do the colon cleanse your daughter did.

  26. Cyd December 5, 2014 at 8:54 am #

    I am all about information and taking charge of ones health. However, I would suggest those looking at 23andme look deeper into this company. The data mining on the Internet is great. Google is king of it and this company is the Google of your DNA data. The CEO also happens to be in the Google family. Here is just one article of many to be found on the net. Be informed, but be careful. Your DNA is very valuable information.

    Just so you know, I was tempted to do this test. Just found out my child is Mthfr positive and struggles in many areas. So my interest is genuine.

    Good luck to all in your search.

  27. Stephanie December 12, 2014 at 2:16 am #

    Hi Dr.Lynch ,
    I just ordered 23& me for me & my children . I have a son with autism . I am 34 , newly diagnosed with two mutations of c1667. I am trying to research all I can , I’m very sick, I need a good Dr to help . When will you be doing conferences in Vegas again? I told my primary Dr , I would pay him to go to your conference ! I was on methyl- guard & made me too tired. That is the only way he knows to treat MTHFR. Please come here soon ! Or reccomended a Dr out here in Las Vegas, Nevada for me to see ? PLEASE
    Thank you !

    • Dr Lynch December 12, 2014 at 6:21 am #

      Hi Stephanie –

      Please inform your doctor about these online training courses – will help him immensely – and you.

      Here are a list of doctors – expanding all the time.

      • Maria March 6, 2016 at 5:51 pm #

        I’ve tried searching for NY, CT and NJ and no doctors come up? What am I doing wrong? Can a radius search be included?

        Thanks, Maria

    • Amanda March 21, 2015 at 2:05 am #

      Stephanie, have you found a doc in Las Vegas yet? I am also ooking for one knowledgeable in LV.

      • Shelly August 10, 2015 at 11:44 pm #
        Dr. DiMartino is VERY knowledgeable about the genetics. He is in Henderson. I live in Las Vegas and he was able to help me determine that mycotoxins from black mold were what was making me sick for three years using only my genetic report and NutriEval. I had been to three doctors prior to him figuring it out for me. He was spot-on. The office where I work is full of Stachybotrys and I carry the HLA mutations. He is a chiro but I recommend him highly. Dr. Bell is a biological dentist that understands MTHFR as well.

  28. Jana R January 10, 2015 at 6:15 am #

    Hi Dr Lynch

    Do you know what might happen if an adult with a history of sulfite/sulfa/histamine sensitivities took 5-MTHF plus Calcium Folinate if they don’t actually have the MTHFR gene and were incorrectly diagnosed?

    Don’t mean to put you on the spot and realize everyone is different, but generally speaking, what are the chances of a negative reaction? Thanks – Jana

  29. JJ January 13, 2015 at 1:19 pm #

    Jana, this thread is about getting tested for MTHFR…

  30. Jana R January 13, 2015 at 3:45 pm #

    Ooops… sorry… didn’t read all of the posts and assumed it was ‘general’, not specific to any one topic… didn’t mean to derail the Thread — was not my intention.

    I don’t have the money or insurance coverage or support system to help me to get the test done. But am positive I have the MTHFR gene. I thought maybe if I just take the supplements and feel better after a few weeks on them, then there’s my answer.

    No need to reply. People do out of character things when they are desperate in pain and need answers. I’ll look for the appropriate Thread and copy & paste this post on there.

    Thanks… no need to reply here. It will disrupt the flow of the Thread. Jana

  31. Ms W January 14, 2015 at 9:55 am #

    I’d LOVE to do this and would like my information to be as through as possible. However 23andMe has removed following SNPs:
    MTRR H595Y (rs10380)
    MTRR R415T (rs2287780)
    BHMT-04 (rs617219)
    AHCY-02 (rs819134)
    CBS N212N (rs2298758)
    SHMT1 C1420T (rs1979277) so it’s clearly not as informative as it was. What I’d like to know is which dna tester provides the most thorough snp information.


  32. JJ January 15, 2015 at 3:13 pm #

    Genetic Genie only accepts 23andme raw data. You will get the most value from them. It’s not necessarily about testing the most SNPs, it’s about which SNPs have been researched and are actionable.

    This question was answered when 23andme changed to their V4 chip; Google is your friend.

  33. Vicki January 24, 2015 at 10:58 pm #

    Dr. Ben,

    I’m not sure if you remember me (back when you used to consult), you helped me with my son Jackson. He had lots of gut issues which we have finally mostly healed. (It has taken YEARS) He still suffers from fatigue, exhaustion, loss of energy, PANS etc… because we have not figured out how to successfully supplement yet. Can’t tolerate Epsom Salts and takes D-Hist for allergies and I’m afraid that is wrong. Sometimes does well on fish oil and sometimes not. Very confusing!!! I’m hoping you or someone can help me make sense of his 23andMe results:
    ene & Variation rsID Alleles Result
    COMT V158M rs4680 AA +/+
    COMT H62H rs4633 TT +/+
    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 CT +/-
    VDR Taq rs731236 AG +/-
    MAO A R297R rs6323 T +/+
    ACAT1-02 rs3741049 AG +/-
    MTHFR C677T rs1801133 GG -/-
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 GT +/-
    MTR A2756G rs1805087 AG +/-
    MTRR A66G rs1801394 GG +/+
    MTRR H595Y not found n/a n/a
    MTRR K350A rs162036 AA -/-
    MTRR R415T not found n/a n/a
    MTRR A664A rs1802059 AG +/-
    BHMT-02 rs567754 TT +/+
    BHMT-04 not found n/a n/a
    BHMT-08 rs651852 TT +/+
    AHCY-01 rs819147 TT -/-
    AHCY-02 not found n/a n/a
    AHCY-19 rs819171 TT -/-
    CBS C699T rs234706 AA +/+
    CBS A360A rs1801181 GG -/-
    CBS N212N not found n/a n/a
    SHMT1 C1420T

    I want to help him. He’s better, but not his best.

  34. Dominick January 26, 2015 at 1:55 pm #

    Hi Dr Ben,

    I am a UK trained osteopath practitioner working in Ottawa with a strong interest in Functional Medicine. I am been recently learning a lot about MTHFR through your website. I am interested in beginning testing firstly for my family, like to try things first and then my clients. I recently came across a report on 23and me in the Canadian Press and wondered if you had any comments?

    Kind regards


  35. Maxine January 30, 2015 at 7:24 pm #

    Hello DrLynch. First I want to thank you for all your informative information and research. I have a question regarding getting the genetic testing done. I am in a nightmare with medical issues, chronically ill, and Drs which seem to care less of any of my symtoms, or actually Diagnoise’s I have. I talked my PCP into doing a Clotting test for me. He is a Internist, (new dr in a small town and they all seemed to be overwhelmed and no time for patients) Ok I have heart issues, many other illness’s. A long list. Hashimotos, Fibro, osteoporosis, Ashtma, arthritis, Sinus issues and recently diagnoised with CF. Ok on the blood work, one came back positive, High. This is what lead me on the search and found you. I have homocyst(e)ine, Plasma at 15.4. Reading about this and I am a woman, Seems that is considered High period. I have been concerned with Heart issues, Prior MI. Valve leaks, CAD, Diastolic dysfunction, a eco back in 2011 show cardiomyopathy with stenosis, and Arterial right and left enlargement. I was not told any of this and as far as my care goes, I just keep getting the blow off. I have abnormal EKCs.. I have a pace maker. Hole in heart , called this a PFO, but it is a left to right shunt. Has me very concerned with all the recent chest pains putting me in the er, and what I have read, a PFO is only a right to left shunt, and a ASD would be left to right. With the diastolic dysfunction, I am so concerned about PH. and recently, was released from ER with a 75% probably PE!! I have suspected I have some kind of clotting factor going on. I was diagnosed yrs ago with the first episodes of Chest pains, with presmetal angina. Now these Drs just over look that. I am so frustrated beyond what words can even say. I have spasms it seems every where. Stomach, bowels, esophagus, and In the artery for ABG, was told that. A angio confirmed spasms! I am on no heart therapy at all. Just dismissed. Now getting back to this gene and figuring out , how I can get this Dr to test further for the genes, because it seems to be a cardiac marker for all the problems I have had. Like a piece of the puzzle. All I got from the nurse was a email on my results, stating this test was a little elevated and the Dr said it is a VIT B 6 issue? that was it and wants to check my VIT B. Nothing said about I am at high risk and it is a Cardiac Marker. I also did a kit with the 23&me for the IBD study. So I do understand the test will have Raw data, correct? So will this help me in trying to find out if I have a genetic mutation or not? How can I proceed to try and get this Dr to do the genetic test, and then from there any info for someone like me dealing with heart problems and continued chest pains. Thanks

    • framistat January 31, 2015 at 8:46 pm #

      Maxine, you say you had a test done with 23andme. Do you have your password to the website? You can login and download your raw data and save it on your computer. Then go to the website, upload your data, it’s $5 for a comprehensive report. You probably won’t understand much of it, you will need help interpreting it. You don’t need a doctor to get the report, you do it yourself.

      • Maxine February 2, 2015 at 2:05 am #

        Hi. Hope this goes to the person who replied to me. I joined the IBD study, Through the me&123. I Know they are not doing health anymore. But The test I understand, you get your genetics and RAW data. Yes I have my password, Just have not got back any reports as of yet. I am confused though, with the 123 not providing any health genetic info at this time, exactly what I will get back, and can I down load that data? Can’t do anything until the test comes back though. take about 4 more weeks. Thanks (who can I get to help me to interpret the test??

      • Maxine February 19, 2015 at 12:37 am #

        thanks so much for the info . I am having so much trouble with all of this. I just posted my results from one of the sites here. Hoping for some help. I will go to the other site you gave me also. Appreciate it. Also having trouble here, trying to find the post after I already posted it!

  36. Carol February 3, 2015 at 11:54 pm #

    This is what the website, 23andme says about their MTHFR test:

    We no longer offer our health-related genetic reports to new customers to comply with the U.S. Food and Drug Administration’s directive to discontinue new consumer access during our regulatory review process.

  37. framistat February 4, 2015 at 3:21 pm #

    If you READ this article – you still have access to your raw data – you download that, then upload it to other sites like Genetic Genie or Promethease, which analyze it and produce a report.

  38. Fred C February 12, 2015 at 10:38 pm #

    If you read 23andMe site they are updating all the time. I just had report done then went to MTHFRSuppourt and downloaded data for a FORTY TWO PAGE REPORT!!!!!!! After reading older replies I say “what do you want?” Cost is $30. There are 114 different SNP’s under Methylation & Methionine/Homocysteine Pathway with 11 MTHFR markers!! To all: I would reload data. FMC

  39. Maxine February 19, 2015 at 12:31 am #

    Ben, I have the raw data from the 123 site. I submitted it to the one site, the MTHFR site is having trouble right now from what I gather. What is the Detox DNA? Who can help with this? Can I upoad this here also> I am very sick and with little answers. to be as short as I can be, I am not getting much answers in the medical field and just being blown off basically. I have heart issues and have been concerned of a clotting factor. Talked the Dr into doing a clotting test and the homocyst(e)ine, plasma came out at 15.4. I am a woman 59. I read quite a bit about this and seems that is very high for a woman. which lead me into looking into the MTHFR and you. I have Heart issues, chest pain, constant now, afraid I may have a clotting disorder. ER ambulance rides, 5 last yr . High d-dimmer along with a 75% probably PE, by ventilation perfusion scan. Clots run in my family. I am being ignored by the medical community. This last test, the Dr just stated I might need Vit b6. Not concerned about the heart issues related. I have a pace maker, deal with chest pains and tightness daily. Living on nitro most daily. Have fibromylisia, CFS, Chronic Dyspnea, SOB, very fatigued among a bunch of other health problems. tested Positive also for CF, still getting the run around on this! This is why I am so interested in genetics and where I live, seems no Dr are. A not so good place for medical care. I am listing my info on the data I received from the one site. In input or help , or anyone Gene & Variation rsID Alleles Result COMT V158M rs4680 AA +/+ COMT H62H rs4633 TT +/+ COMT P199P rs769224 GG -/VDR Bsm rs1544410 CC -/VDR Taq rs731236 AA +/+ MAO-A R297R rs6323 GT +/ACAT1-02 rs3741049 GG -/MTHFR C677T rs1801133 GG -/MTHFR 03 P39P rs2066470 GG -/MTHFR A1298C rs1801131 GG +/+ MTR A2756G rs1805087 AA -/MTRR A66G rs1801394 GG +/+ MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/MTRR R415T rs2287780 __ no call MTRR A664A rs1802059 AA +/+ BHMT-02 rs567754 CC -/BHMT-04 rs617219 __ no call BHMT-08 rs651852 CT +/AHCY-01 rs819147 TT -/AHCY-02 rs819134 __ no call AHCY-19 rs819171 TT -/CBS C699T rs234706 AG +/CBS A360A rs1801181 AG +/CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call
    Name: Maxine Simon Profile: Methylation Profile Generated: 2/18/2015
    Methylation Profile generated by Page: 1which can help would be very much appreciated.
    This is what it says about all this:
    You have homozygous (red) mutation(s). These are the worst type of mutations. They include:
    MTHFR A1298C
    MTHFR A1298C

    Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR):
    Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):
    MAO-A R297R BHMT-08 CBS C699T CBS A360A

    • Fred C February 19, 2015 at 5:47 pm #

      hey Maxine: I would wait for MTHFRSupport to update as they have a great product. What is your Vit. D level? Resent MAJOR studies showed 90% of type 2 diabetics had low D and low D was associated with heart attack, stroke, arteriosclerosis, and sudden death syndrome!!!!!!! I have read levels over 50 with 1 comment stating 80. My D has been low all my life and when I got it over low limit my lipid pnl was lower then ever!!! Use D3 which is cheap. Dr Lynch has a good product. Also don’t forget to talk with you Dr!!!! Note: I talked to mind and stated “everybody has low D” My comment “maybe that is why heart disease is USA #1 killer” Good luck.

      • Maxine February 19, 2015 at 6:42 pm #

        Thanks for the info. My Vit D has been low in the past. I take the D3 daily. Don’t know where it is at now, but they have said it is fine in this last yr. (I am fighting care where I live and do not want to even get into this) I am on my own, doing my own research, trying to figure out myself. Any good Drs I have are out of this area. Other then that, Forget getting any help. I also wanted to know, which seems weird with the DNA results I have, Does that mean I have a Double MTHFR A 1298C? I wonder then why my Homocyst(E)ine level was high? 15.4 Not only is this a gen they seem to Ignore , like the Dr says, but also I don’t understand why my Levels are high (which by the way , my dr has no concern about it anyways, ) I am so frustrated and have to many things wrong with me, to try and figure this out!! You know when you are dealing with a multitude of health issues, One med for one disease, may be horrible for something else you have!!! Same as vitamins , how you eat, etc etc.. I need First to know what I have and what is off in my body?? Second I need a nutritionist, and a good PCP which will put this whole puzzle together and help me!! I just am so frustrated right now.

  40. framistat February 19, 2015 at 7:22 pm #

    Most allopathic doctors know very little about nutrition, MTHFR, how to test or how to treat with drugs rather than supplements. If you continue to look for this kind of care from that kind of doctor, you will continue to be frustrated.

    I suggest you look for a functional medicine practitioner, perhaps one trained by Dr Lynch, and take your results to them. If finances are tight, ask them to arrange as much testing as possible in a way that your insurance will pay for it, and get an estimate up front for how much they think your treatment will cost over whatever timeframe they are considering. By the way, MTHFRSupport is offering their report for only $10 until the end of the month… usual price is $30. I have no affiliation.

    I also suggest you start getting copies of your records from any tests or doctor visits. You can request them for past tests and visits as well. You may have to sign a form, you may have to pay a small fee, you may have to be persistent, but you can get them. It would be helpful to have these when you go to a new doctor of any stripe. It will also help you to understand your conditions, for example, you should know what your vitamin D level is. If you had a copy of your lab report, you would know.

    Knowledge is power. Go for it. But go to the right places, and nurture a positive attitude.

    Be sure to click around on this site, find Dr Lynch’s videos, watch them, listen to his podcasts, find other places where he is interviewed and listen to those, too. You should be able to answer your own question about your homocysteine level after you’ve done this.

    Best of luck to you.

  41. nicole February 20, 2015 at 6:27 pm #

    Hi Dr. Ben, thank you for all the great information! The pediatric geneticist at Albany Med is willing to run further testing on my daughter, who is homozygous for C667T, but we’re not sure which test to run. What SNPs should we be looking for in terms of methylation pathways? Also, my daughter has crazy full body itching to the point where she has had trouble making it to school for the past 3 years. Are there histamine related genetic SNPs we should look for?

    Thanks so much!

    – Nicole

    • Dr Lynch March 2, 2015 at 7:59 am #

      Nicole –

      Sorry to hear about your daughter.

      Foods are a common cause of full body itching.

      The slowed MTHFR enzyme, along with slowed methylation, also may contribute to higher histamine levels. You can check her histamine levels and see how they are doing.

      If she is not eating enough methionine, that may cause increased itching – and methionine comes from protein.

      I am not sure of your daughter’s age but I know that Methionine has helped some people in the past quite well with itching – however – again – it is only one possibility out of many others.

  42. Karen March 21, 2015 at 2:30 pm #

    Do both brothers have to take the 23andMe test if they have the same mother and father ? Would the results be different? I suppose they would be.

  43. Doreen May 4, 2015 at 1:29 pm #

    You may have noticed that there are two states which are precluded from using 23andme. If you live in either NYS or Maryland, you are not able to use any of these online options. This puts many who are in need of this sort of testing at an extreme disadvantage. Are you aware of any way to get around this or is there any known group you know of that is trying to change these outdated restrictions?

    Thank you.

  44. Diane Baer May 13, 2015 at 6:36 pm #

    My Doctor ordered MTHFR, DNA Analysis test from LabCorp and it was negative for C677T and C1286A. LabCorp uses PCR Amplification followed by restriction analysis. It is molecular based testing and has a diagnostic sensitivity of >99%. My sister had the SpectraCell MTHFR Test run which uses dioxorybonuclear Acid DNA Genotyping. SpectraCell admits to using a different method to arrive at their diagnosis.My sisters test result is Heterozygous C677T. Should we both be heterozygous? Should I be concerned about the inconsistency between siblings?

    • Dr Lynch May 26, 2015 at 11:44 pm #

      It is possible for one sister to be heterozygous for one and you not have anything.

      If you are concerned about the validity, I do recommend testing with Spectracell. It is what I also prefer – along with Molecular Testing Labs – or 23andMe.

  45. Carolyn White June 24, 2015 at 3:22 pm #

    Would the procedure code be the same in all cases? If so, could someone tell me what that code is? My insurance would only tell me that they need the code number to say if the test is covered.

  46. Anne Parker August 11, 2015 at 3:47 pm #

    I’m a psychiatrist and a Mom. LOVED your MTHFR talk. Not stumbling around quite so blind! Haven’t found anyone in the medical community here up on this. The first patient I got to get the test done HAS one C677T (migraines, depression, and recurrent breast cancer) but they don’t want her taking ANY kind of folate supplement! (Yet they do the Leucovoran rescue thing!!) Have you got a “good” article (re UMFA) I can share with them?

    Just sent off for 23 and me for myself (ADHD, LD, Depresion, Migraines-before I got on Gabapentin) my daughter (5-Leiden from Dad’s side, and Migraines) and son (also 5-Leiden, ADHD, LD, Anxiety, addictions, but never s migraine!)

  47. Rick August 11, 2015 at 10:49 pm #

    Dr. I just had a blood test and the results for coagulation genetics MTHFR C677T were T/T -10.9, homocysteine was 13. My dr. wanted me to take Metanx, but I am thinking of taking Optimizes Folate L-Methylfolate 1000mcg by Life Extensions. Am I on the right track? Let me know if you need more info. Thanks !

  48. Sarah November 30, 2015 at 5:58 pm #

    Forgive me if this has already been covered, as I could not read every single post/comment. I am wondering if MTHFR would cover a medical exemption from a full vaccine schedule?

  49. Becky Grava Davis December 20, 2015 at 2:57 pm #

    Would you please update the 23andMe info & resend? Thanks.

  50. Deborah January 1, 2016 at 6:05 pm #

    After reading so many of the comments and dealing with a health issue that initially was MS like symptoms without lesions with high inflammation of unknown origin after 2 years of testing of every kind. Everything normal except the high inflammation and of course my complaints, which was just my antidotal word, so it’s Fibromyalgia diagnosis, 1993. Two bouts of Cancer, Cervical, 1991, and Uterine, 1999. Almost every Fibromyalgia symptom, plus a dead Thyroid ate up with nodules, cause unknown, benign assumed because not large enough to biopsy per insurance coverage. Kidneys third stage failure and fourth stage fluctuations, unknown cause. Degenerative Disc disease.

    Okay, all that to ask this, considering I am on Disability and a Veteran so I now use VA insurance, which is as likely to test me for DNA anything as their is an Easter Bunny, so I am paying for this test out of pocket, and for physicians if need referrals. But I sincerely believe I believe testing is a good thing, considering, all the Cancer History mine, and ancestors, and other medical factors.

    With the inflammation, kidney disease, and thyroid disease, which is the very best test option?


    • Dr. Aron January 23, 2016 at 12:47 am #

      Deborah – I wish I could tell you which tests were the best for you, but it’s not possible without doing a proper intake. I recommend reaching out to a doctor on the Physician Directory. Some do consults and may be able to point you in the right direction. Wishing you the best. Please keep us updated on your progress.

  51. Joan January 8, 2016 at 7:23 pm #

    Please remove 23andme as a test for MTHFR. I spent over $400.00 for this test for both daughters only to find out that it did not test for this.

  52. TLP January 15, 2016 at 6:07 am #

    23 and me has recently released their new product (as of a little more than a month or 2 ago as of Jan 2016) and the cost is now $199. They give limited reports about your specific data. I’m assuming they still give your raw data to you. Looking for any information anyone can provide about the current product and how it differs from the other products currently out there. It seems much of the info in the above article and commeets are perhaps outdated. I very much wish to get tested but have run out of hope that I can get an MD to facilitate this for me to be covered by insurance. I was about to order the 23 and me test but then it doubled in price. Just want to make sure it’s the best option before paying the $200. Any advice is appreciated.

    • Estelle June 11, 2016 at 4:34 pm #

      23andme have confirmed to me that they no longer run the MTHFR tests. I fell into the trap of ordering a test only to lose and waste $200 because they have no return policy.

      For the sake if everyone else who excitedly orders the 23andme test please remove all your references Dr Ben

      • Dr Lynch June 18, 2016 at 12:46 am #

        Estelle –

        23andMe does test for the MTHFR 677 and 1298 variants. They have this in raw data format. They do not include it in the health reports – never have. You need to use a raw data report tool to provide this information. I’ve created one which we’ll be releasing very soon at – called SHEIKEY.

        You did not waste your $200 😉

  53. framistat January 23, 2016 at 11:42 am #

    You need to look for a functional medicine practitioner, not an allopathic doctor. There are some that practice online but you will need to see them once in person.

    Most functional medicine docs do not operate within the medical establishement; however, they are very concious of costs for their patients and will try to have tests covered by insurance when possible. Just be aware that you will be incurring some costs outside the system to get what many with chronic illness consider to be better care.

    The 23andMe test has not changed; only the website and the reports they provide. The raw data is still the same. The third party websites that report on the raw data are the same or have improved.

    23andMe is still the best bet for testing. Most third party websites that report health data use their format. If you get tested with another service you will have very limited options for health reports from that data.

    23andMe DOES test for MTHFR and other relevant SNPs and the information you need is in the raw data.

  54. michelle February 15, 2016 at 10:09 pm #


    I heard with 23 and me (and possibly other testing facilities) is that they keep your test results and this data “could” potentially be available for sale in the future. Although this isnt their intention now, the risk is still there. What are your thoughts on this?

  55. Saundra White March 14, 2016 at 9:02 am #

    Hi Dr. Ben,

    I see that you show the cost of the MTHFR test on 23 and Me as $99, but when I click on the link and go to the site, it shows the cost as $199. Am I missing something?



    • Dr. Aron March 15, 2016 at 1:39 am #

      Saundra – 23andme periodically changes their prices. we have updated the blog post with the current $199 price. There is a 10% discount for each additional test kit.

      • Saundra White March 15, 2016 at 7:39 am #

        Thanks for the clarification!


  56. Estelle June 11, 2016 at 4:31 pm #

    Dear Dr Ben,

    23andme have confirmed to me that they no longer run any MTHFR tests. I fell into the trap of ordering a test only to lose and waste $200 because they have no return policy.

    For the sake if everyone else who excitedly orders the 23andme test please remove all your references.

    Thank you!

  57. Laurence McFerren July 24, 2016 at 5:01 am #

    Important to know along with mthfr mutations are dhpr mutations. Does 23 & and me address dhpr mutations. Is there another company avail. for this test w/out need for physician? I’ve suspected dhpr to be a problem for some 15 years.

  58. kate t August 10, 2016 at 4:47 pm #

    Good question. If i want to get tested for this via my doctor, what test should be ordered and via whom? I found out that my insurance DOES cover “genetic testing”.

  59. Danielle Dalton September 29, 2016 at 5:20 am #

    I have 4 kids and have the MTHFR c677T mutation. All of my kids have s/s that make me suspect they may have the mutation as well. I need to get them tested as well. I’m wondering, what would be a safe amount of methylfolate and methyl B12 for supplementation for a 1,2,5, and 7 year old? I’ve tried to change their diets according to my own, but I need to know how else to address this with them. Thanks for your time.

  60. Sonia November 4, 2016 at 2:06 am #

    Dr Ben.I have been diagnosed with depression and anxiety 10 years ago .I have been on and off on Cymbalta.I have spend hundred of $ changing dr and what upsets me is how come 7 difrent doctors that I went no one checked hormones or anything..Ever.Anyhow I did checked the thyroid and hormones not to long ago so everything looked normal.There is definitely something not right with me I am tired angry for no reason at all. I am searching online to see if I could find a way of replacing the antidepressant with something natural .Please let me know how can u help me ?

  61. Leslie Slavens December 2, 2016 at 6:00 pm #

    Bottom line, Deplin is helping me immensely. The cheek swab and MTHFR diagnosis were definitely warranted. I have TRD, treatment resistant depression and take a plethora of drugs, some of which are used for seemingly unrelated illnesses. As far doctors calling a helpful practitioner names I most definitely would not let this mean spirited doctor touch me

    • Teryl Wales-Paschal December 3, 2016 at 7:28 pm #

      Leslie I did a test from a company called Gene sight. They test how well you metabolize certain classes of drugs such as antidepressant and nsaids excetera. I highly recommend this test for you. You probably don’t metabolism many medications. This happened to me as well. I have since quit taking all the drugs I had been prescribed that my body cannot process. But I think because of my mthfr, it’s taking me a longer time to move them out of my system.

  62. Lynne Starrett January 18, 2017 at 7:47 pm #

    I had already sent my cheek swab test to National Geographic Genom test for another reason before my accupuncturist discussed MTHFR with me.. Will those results contain MRHFR results?

  63. DeAnn Covington February 16, 2017 at 1:05 am #

    Our daughter has lesions in her brain that are due to low vitamin b12 levels. She has been on Injections for 9 months. Her levels were 197 and now are 278.Her new Internist put her on weekly b12 shots and did the MTHFR gene test. It showed she had a single copy of the mutated gene A1298C for synthesis of folic acid and b12. I her mother found out I am the carrier. My Dr said it doesn’t affect me. Is this true? Our family has numerous health issues.

  64. Carol April 4, 2017 at 12:02 am #

    If you have your MTHFR tested and Quest (Care360) blood says positive for one copy
    (A1298C) variant but you the had a genecept assay report and it says there is no known
    gene to drug intereactions on the MTHFR which would be correct

  65. Laur April 30, 2017 at 12:37 am #

    23 and me now offers two testing options. Does anyone know if the full amount of raw data is also available for the cheaper one at $99 versus $199? If so, then I guess that is the better route for those of us simply wanting the raw data reports.

    • Dr Lynch May 2, 2017 at 10:59 pm #

      Raw data amounts for the $99 vs $199 are the same. The less expensive version will offer you the same amount of raw data.

      After you run your 23andMe – consider to run your raw data through. It provides many benefits and clinical relevance.

      • Laur May 3, 2017 at 1:13 am #

        Wonderful! Thank you.

    • Teryl Wales-Paschal May 4, 2017 at 5:26 am # also now offers raw data and their test pulls out more dna than 23nme. Also I’ve seen some screaming deals on it. I got mine for 89 +shipping but have seen it cheaper since. also support their raw data files now so I think thats the way to go as of now. 23nme could not extract my data as they said there was not enough genetic material in my saliva. They refunded my 199 and now I’m waiting for results from

      • Jackie Armstrong July 4, 2017 at 9:57 pm # does not say on their website that it includes raw data. Is it an add on? How do we know it includes more than 23anMe? Do you have a referral code?

  66. Brad May 4, 2017 at 2:51 am #

    23andMe no longer returns the MTHFR results in there DNA results.

    • Dr Lynch May 10, 2017 at 2:02 am #

      yes they do. They say they don’t – but they have the raw data to do so. Once you order your 23andMe – you then export the raw data into Then you will see your MTHFR status along with other key SNPs 😉

  67. maeva February 23, 2018 at 11:56 am #


    I was on the phone with 23andme and they told me they don’t test for the gene mutations?
    Did that change recently? can someone shed some light on this?

  68. Dr. Michael Goldstein October 27, 2018 at 4:55 am #

    One lab that you did not mention and that I use with accurate results is Vibrant Clinical Labs. The turn around time is about one week. The cost is very economical at only $50. It can be done either with blood, buccal swab (may take more than one try. There is no additional fee to the patient if is done a second time.

  69. Liz Le Mare December 19, 2018 at 4:39 pm #

    I have just recieved my 23 and me results which I then uploaded to FINDMYFITNESS{Dr. Rhonda Patricks’ site}. I have mutations on the MTRR and MTHFDI genes. I know this is not the MTHFR gene, but there seems to be some crossover in the folate pathways. I have high homocysteine which the MTRR gene defect seems to be aplayer in. People with this can have elevated homocysteine due to compromised methylation to methionine. I’m wondering if Dr. Bens site can help shed some light on how to help myself {and other family members} or if someone can direct me where to get help. Thank you so much for your time. Liz

  70. Lisa February 22, 2019 at 9:53 am #

    Does anyone know now that it is 2019, what the best test /comprehensive (and the most value) is now for MTHFR? Is it still 23&me and then running it through or is it Ancestry, or something else now?

    • Dr Lynch June 24, 2019 at 4:32 pm #

      Hi Lisa –

      The most up to date is going to be StrateGene Genetic Test which comes out this Fall 2019

      It is far superior than 23andme and others.

      I highly recommend waiting until it’s released

  71. Michael Moore December 31, 2019 at 9:15 am #

    I did a labcorp MTHFR serum panel for my kid which came back heterozygous for the MTHFR A1298C variant (one copy).

    Recently we did a GeneSight PHARMACOGENOMIC TEST and they also did MTHFR which came back ‘homozygous for the C allele of the C677T polymorphism in the MTHFR gene (normal folic acid conversion). [Analysis of MTHFR was completed by using iPLEX MassARRAY® technology (Agena Bioscience).The following genetic variant may be detected in the assay: MTHFR 677C>T (NM_005957.4:c.665C>T)]

    So this is compound heterozygous and why do the two tests speak of different things?

    We got the generic Metanx (Foltanx) a few months back based on the serum results

    • Dr. Ben Lynch January 17, 2020 at 1:20 pm #

      I cannot tell you how many times I’ve seen conflicting genetic information because of horrible lab standards.

      What you are reporting is really interesting because GeneSight reports that no MTHFR 677 variant was found but nothing mentioned of the MTHFR 1298 variant.

      I suspect your son has 1 copy of the 1298 variant which is quite mild.

      Be careful on supplementing methylfolate based on any lab results or genetic tests. Only lab result which may lead me to prescribe methylfolate is high homocysteine and low dopamine.

      The Metanx can really aggravate your son and turn him into an unhappy kid.

      Please read Dirty Genes and act on what you read in those pages. You’ll learn so many actionable things which are easy to implement and do not require so much supplementation.


  1. mthfr DEFECTS AND THE EFFICIENCY OF THE ENZYME | Nutritionnewjersey's Weblog - November 23, 2014

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