About

MTHFR.net is the leading resource for unbiased, researched information strictly about the MTHFR mutation.

I believe the MTHFR gene mutation is a highly significant public health problem that is completely ignored. Yet, millions are suffering from pulmonary embolisms, addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer and autism to name a few.

What do these conditions have in common?

They all may be linked to a MTHFR gene mutation in the individual expressing these symptoms and health conditions.

If we can prevent the turning on of the MTHFR gene mutation in unborn infants, how huge would that be? MASSIVE.

If we can reduce mental illness, addictions, cancer and cardiovascular disease related deaths, how huge would that be? MASSIVE.

If we can get MTHFR mutations on the map and get standardized medicine to begin screening for it, we can truly make a difference. The lab test to determine which MTHFR mutations are present is only about $150.00. That is nothing.

With all that said, you can see why I have created MTHFR.net.

I encourage you – highly encourage you – to help me gather as much information as possible about MTHFR gene mutations and get it out there.

If you have access to media, and you resonate with my purpose of MTHFR.net, please do get in touch with me.

I’m tired of treating disease. I want to prevent it.

This doesn’t mean I am going to ignore helping the many who have MTHFR gene mutations – especially of the C677T or the A1298C or worse – both.

I am constantly in research looking for ways to improve the lives and health of all those with MTHFR mutations – no matter how minor and no matter how severe.

I have a solid understanding of MTHFR mutations and expanding that knowledge on a weekly basis.

I look forward to hearing your story.

More importantly, I look forward to improving your life – and perhaps saving the life of a family member with an unknown MTHFR gene mutation.

Dr Ben

27 Responses to “About”

  1. Danielle Williams September 21, 2011 at 8:22 pm # Reply

    I have a daughter diagnosed with autism spectrum disorder. I just started research on the gene mutation, and I was wondering how I could get my daughter tested for it. I live in Michigan, and we are struggling financially. Is this kind of testing covered by insurance. Is it a blood test? Any information on the subject would be greatly appreciated. Thank you.

    • Dr Ben September 21, 2011 at 9:56 pm # Reply

      Danielle –

      Please read this article on how to order a MTHFR test.

      Best,
      Dr Ben

      • Dannielle February 1, 2013 at 4:03 am # Reply

        I have already been tested. My understanding is that I have a split – towards possible heart problems & depression. Does this make any sense?

        Thanks for your help!
        Dannielle

  2. Confused in California September 27, 2011 at 8:44 pm # Reply

    I understand that women with mutated BRCA genes are at risk for breast and/or ovarian cancer. Are women with mutated MTHFR genes (compound heterozygotes) at the same risk of getting breast and/or ovarian cancer? Has any connection between the two genes been found to date?

    • Dr Ben September 28, 2011 at 3:59 am # Reply

      Ovarian cancer and MTHFR mutations is conflicting in the research.

      There are links with breast cancer and MTHFR – mainly stating there is a link but also that there isn’t.

      Here is what I wrote a colleague of mine recently regarding breast cancer and MTHFR mutations:

      Here is a study which shows potential BRCA risk with compound heterozygous MTHFR

      Here is a study which did a great job – and shows association with MTHFR mutations and breast cancer – they not only looked at MTHFR – but also levels of GSSH, homocysteine, folate levels –

      Here is one that is conflicting – says MTHFR is not useful in breast cancer diagnosis but useful in survival.

      The other issue is MTHFR genetic defects purely identify potential risk – not absolute. It all depends on the person’s nutrient intake, exposures, occupation, lifestyle and environment they live in. This may explain why research is conflicting.

      One must feel in control of their genetics and not let a mutation bring them down or feel powerless.

      You control the turning on and off of these mutated genes through positive thinking, nutrients, reduced toxicity levels, healthy diet and detoxification methods.

      To me – it is empowering to know that you may have these mutations and be able to do something about them.

      The other side of the coin is you’d have no idea you have the mutated genes and go on through life not being as careful as you otherwise will be now knowing the increased potential risk.

      In health,
      Dr Ben

  3. Carolyn February 9, 2012 at 2:04 am # Reply

    I am heterozygous for MTHFR C677T and A1298C. So is my daughter with autism. Another daughter is homozygous for the C677T and my mother is homozygous for A1298C. My doctor wants to simply supplement my daughter with autism with folic acid and B-12 and B-6. Is this enough? Doesn’t one need the broken down variety of folic acid? Will Medicare/Medicaid cover It?

  4. Victoria February 10, 2012 at 6:52 pm # Reply

    Dear Dr. Ben,

    After a couple miscarriages 4 years ago, I learned that I had 2 MTHFR gene mutations; C677T and A1298C. Currently, I am very concerned about my mother. She is in a mental hospital, and has been recently diagnosed with Parkinsons. I spoke to the psychiatrist who was open to testing for homocysteine levels, as well as various other things. However, he said that if her homocysteine levels are not elevated, that it would not matter if she had the MTHFR mutation or not. Is that accurate? Thank you!

  5. Kim March 7, 2012 at 3:30 pm # Reply

    I am a breast cancer survivor and have both the c677t and A1298c mutation. No one, even local hematologists, can give me any insight regarding what to do to monitor any complications or move toward optimal health. Any suggestions?

  6. Cathi March 27, 2012 at 5:42 pm # Reply

    Not sure where I submitted this, but dr. Ben, maybe you can help. I have one copy of C677T and one copy of A1298C. I keep relapsing with Lyme, have a dozen lesions on my brain, have hyponatremia, psychiatric issues, OCD, depersonalization and on some days mind feels like unreal bubble. I’m taking b-12 methylcobaline, b supreme, working with Lyme doc, naturopath, psychiatrist and psychologist. Perimenopausal 49 yrs old, on Iv rocephin and Zithromax.take 6000 mg salt daily and lasix to keep sodium under control. Of all things, I need the mind stability back. On anafranil and klonopin. Can I be salvaged out of this mess? Looking forward to any help.

  7. sharon January 17, 2013 at 11:32 pm # Reply

    I have had the buccal swab test and have A1298C from both parents (the doctor I was seeing at that time said that both parents were recessive carriers). I have chest pain, shortness of breath, numbness and tingling down both arms (the three wake me up from sleep at night), depression, visual hallucinations, olfactory hallucinations, seizures, arthritis, obesity that I am trying to get under control by diet and what exercise I can do, and memory/cognitive impairment.

    My CRP levels have registered as high as 28 resulting in me being retested-the doctor couldn’t believe it was that high. I feel miserable. I don’t know what to do to successfully help myself to feel better.

    • Michelle February 22, 2013 at 7:29 am # Reply

      Sharon, have you been tested for Lyme? You should look into it. Good luck.

  8. Margaret Rague February 1, 2013 at 4:31 pm # Reply

    Where can I best learn about the link between MTHFR mutations and depression? Thanks!

  9. Jaclyn March 8, 2013 at 2:34 pm # Reply

    At 32 weeks pregnant I loss my daughter due to hydrops. I had the placenta and the umbillical cord autopsied and there was a significant amount of blood clots. My doctors thought I should get checked for maternal thrombophilia. I recently got the blood work back and tested positive for A1298c. It was not fully explained to me and they are not telling me where I should proceed from here? Should I see a hemotologist…where do I go from here

  10. kELLY Gaw March 8, 2013 at 11:44 pm # Reply

    my sister was recently diagnosed with mthfr. it was recommended that the family be tested. my question is, I have suffered from depression, anxiety, and im a recovering drug addict. can this be explained by me having this genetic mutation? I also smoke cigarettes and experience some numb and tingling sensations in my hands and feet. am I at greater risk for the more severe symptoms? thank you

  11. Diana May 19, 2013 at 12:53 am # Reply

    I recently had blood work done and came back having this. Reason I got blood work done was to see if I had a deficiency Protein C but that came back normal. I am 32 years old and have had 3 miscarriages which now researching this comes to be no surprise why. WHat exactly is this and what should I expect? The doctor made it seem like I was ok and normal but only had this “mutation”.

    • Diana May 19, 2013 at 12:56 am # Reply

      They found A1298C

  12. Mary Wyman June 3, 2013 at 8:17 pm # Reply

    My daughter suffered severe anxiety and minor ocd for as long as I can remember now that I look back on it. We finally realized she was not just “a brat” and started getting help. From age 12 to 16 she was on over 10 different medications with no effect. Finally, while looking for help with her headaches we stumbled onto a doctor working with P.A.N.D.A.S. patients and she started testing her. She found MTHFR gene mutation a1298C! Between multi-vitamins and Deplin the difference is amazing! Because it is homozygous my other 2 children take this as well and notice a difference. Much less worry and anxiety! After 18 years my one daughter says it’s amazing to be able to do things without worrying! YAHOO . The Deplin is expensive, especially for 3 people so if you have any less expensive ideas please let me know

    • Gretcgen September 26, 2013 at 3:00 pm # Reply

      Mary, I have a daughter who has been treated for anxiety (SSRIs) since she was 9 years old. She is now almost 20. When she was 17-18, no med would help. In March she tested positive for the MTHFR mutation. She’s now on Deplin & a bunch of supplements. She is improving, but is still suffering greatly. Is your daughter symptom free? How long did it take?

      • Mary Wyman September 26, 2013 at 9:53 pm # Reply

        Gretcgen, I’m so glad to hear from you – someone who understands! I cannot say she is symptom free. By any means. As you know, ages 12-15 were unbelievably horrible so any improvement is a celebration for me. She still has anxiety and probably misses about a day a week from school due to some minor issue that is huge to her. She also takes 10mg lexapro. We started over with low dose meds now that the Deplin will help them work. Maybe that will help your daughter. We went to the Psychiatrist the other day and when asked if she wanted to up the dose she said no. That tells me she notices a difference and feels less anxiety. I wanted to up it as I still see the anxiety. I think the Dr. thinks Annie needs to make the call. Annie thinks any improvement is great, I know it could be better. I guess we’ll have to take it slow. I do worry about her after HS. I wonder if your daughter has a job or is in school. I wish you luck and hope to talk to you again.

  13. Michael Polasky June 25, 2013 at 11:58 pm # Reply

    I was diagnosed with MTHFR mutations with both C677T and A1298C in May of 2013. This has formed a DVT in my left leg in January of 2009 and recently in the portal vein of my liver in April of 2013. I was required to have surgery on the recent episode due to the backing up of blood and body fluids into my intestines. I was in the ICU for one week and recovery for another week following the surgery.

    I would like to talk to someone who has expert knowledge of this as I was informed that there is no cure, only coumadin (warfin) for life. My Protime levels are suppose to be between 2 and 3 but I am testing weekly around 1.4 to 1.7

    Any help or just someone to talk to about this would be appreciated. This is has been a horrifying ordeal for me these last two months.

    Mike

  14. Susan July 25, 2013 at 5:08 am # Reply

    Hi,
    I recently found out I have both mthfr gene mutations. For years I have suffered from hot tingly feet. Is there a special mix of vitamins . I was told the mutations make it difficult to absorb b vitamins. They gave me Vitacirc b. I was concerned that it might have to much b6 in it as I was told that could be toxic to the nerves. Any ideas or help to relieve my foe would be greatly appreciated.

  15. Amy Rodebaugh November 11, 2013 at 5:24 pm # Reply

    I have the A1298C mutation only. I had a miscarriage at 10 weeks and then my next baby was born a little over 3 months early weighing a little over 1 pound, due to IUGR. Is there anything I can do to help with my next pregnancy? Something I can take or something I should do. My doctors don’t know much about this mutation and haven’t really seemed concerned. Please help! Thanks!

  16. Debbie November 28, 2013 at 1:46 am # Reply

    I have Ehlers-Danlos Syndrome and the MTHFR mutations C677T and A1298C. What is the link (if any) between these mutations and inherited connective tissue disorders?

  17. Josephine Later January 22, 2014 at 2:09 am # Reply

    Dr. Ben–You are remarkably brilliant and 100% correct!!re MTHFR mutations.As a retired Med. Tech(C.S.L.T. and A.S.C.P)-I tried to do my own research,and finding this site was a gift from “Heaven”.
    Since I have been on both sides of the medical miasma–I can truly appreciate Complementary Medicine-Thanks again-Jo Later

  18. Melissa January 29, 2014 at 5:12 pm # Reply

    I am 36 years old. I tested positive for C677T and A1298C paper work said that it suggested that the two were not present on the same gene. Is that better or worse? What should I do with this information? I went in to check my hormones. I feel like my body is breaking down and I’ve had everything checked but my heart. I had some significant deficiencies that can be taken care of with vitamins and RX. One other alarming discovery was the MCV blood platelets are larger than they should be. Please help direct me in the right direction.

  19. barbara February 20, 2014 at 4:59 pm # Reply

    Hello Doctor and thank you for this opportunity.

    Without going into too much detail my adult daughter *dxd Hashimoto’s, PCOS, gluten allergy, EBV+, and now recently heterzygous A1289c. My question is did she always have this mutation? Was it silent until testing a couple months ago? The thyroid she discovered at age 19 and had her left lobe removed – no cancer. The other things at 24. She is 28 yo.
    I cannot find substantial info on what/how she should change things. We are organic, gluten free, no cigs, no toxins, no chemicals, etc. How can I help her? Take her OFF dairy, or go back to Raw for the enzymes?

    Is there a couple really great probiotics she should be taking for sure? Or do we just buy off the shelf – what ever is on sale?

    Is organic red wine out of her life forever? Should she be assisting her liver *milk thistle?

    So many questions. I know. I just can’t seem to find anything. Should she have MORE tests? I say her amino acids – she must pay out of pocket for them and is really strapped financially.

    Thank you again KIND DOCTOR. Many blessings to you, sir :)

  20. terri March 14, 2014 at 11:00 pm # Reply

    Michael, the portal vein issue can also be a Jak 2 gene mutation. My family members have this too.

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