MTHFR C677T Mutation: Basic Protocol

Have one or two copies of the MTHFR C677T mutation?

Don’t know what to do?

After working with 1000’s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.

UPDATE 3/16/2015:
Having written this article years ago now, I must let you know that if ANYONE – with or without MTHFR C677T or A1298C snps/variants/polymorphisms/mutations – whatever you want to to call them – should follow the lifestyle, dietary and environmental recommendations.

Regardless of MTHFR or not, the recommendations for diet, lifestyle and environment need to be considered by all!

Now – the supplement recommendations need to be tailored to the individual – again – regardless of which genetic variants you have. Working with a physician trained in this area of medicine is key.

The recommendations of supplements are merely suggestions and ones that I may recommend to a patient or physician. They are not flat out must-haves nor must one take all of them.

I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of these recommendations require a full explanation. Due to the nature of this article, it is not possible to do so. If the recommendation is listed, it is critically important.

Let it be known that the information presented below is for your information only and is not intended to treat, diagnose or prescribe in any way. Use the information at your own risk.

Always seek the advice from your physician.

Here is a list of physicians that have training in MTHFR, methylation and nutrigenomics.

Part I pertains to supporting both heterozygous (1 copy of C677T) and homozygous (2 copies of C677T) MTHFR mutations. Part II pertains to mainly homozygous individuals but may also be tried by heterozygous individuals if desired.


The biggest differences in recommendations between these two types of mutations are:

  1. folic acid needs to be avoided more seriously by homozygous individuals
  2. the amount of methylfolate required for homozygous mutations is greater
  3. the blood thinning requirement is greater for homozygous individuals

Here are the common recommendations for supporting those with C677T MTHFR mutations:

  1. Limit ingestion of folic acid in fortified foods as you cannot process folic acid well.
  2. Limit or cease taking supplements or drugs with folic acid in them. Talk with your doctor before stopping.
  3. Avoid folic acid blocking drugs such as birth control or Methotrexate.
  4. Avoid drugs which increase homocysteine such as Nitrous Oxide (most used in dentistry)
  5. Avoid antacids as they block absorption of vitamin B12 and other nutrients
  6. Begin understanding which of your symptoms may be related to the C677T MTHFR mutation.
  7. Measure homocysteine levels – properly!
  8. Inform your family members so they can also test for the MTHFR mutation
  9. Find a doctor who is knowledgeable about MTHFR or is willing to learn
  10. If you are pregnant, find an OB/GYN or midwife who is knowledgeable about MTHFR.
  11. Eliminate Gluten from your diet – especially wheat.
  12. Eliminate or reduce Dairy from your diet. If you must have dairy, use Goat milk.
  13. Sauna or sweat somehow (epsom salt baths, sports, yoga..) at least once to three times a week.
  14. Limit intake of processed foods
  15. Increase intake of whole foods and home-prepared meals
  16. Eat the Rainbow of colors from fruits and vegetables – daily
  17. Castor Oil Packs over your abdomen daily during times of pain, soreness, cramps
  18. Vegetable/Fruit Juice Diet with Chia Seeds during times of pain, soreness, cramps
  19. Limit intake of high methionine-containing foods if homocysteine elevated
  20. Coffee Enemas during times of detoxification or pain
  21. Filter chlorine from your drinking water, shower and bath.
  22. Drink at least two liters of filtered water daily mixed with vitamin C and electrolytes.
  23. Eat smaller, but more frequent meals, throughout the day with some form of protein.
  24. Limit protein intake to approximately 0.7 grams protein per kilogram of body weight.
  25. Remove mercury amalgams and root canals with a trained biological dentist.
  26. Avoid cooking, drinking, storing and heating in any type of plastic container.
  27. Use an air purifier in your home and office
  28. Eliminate carpets from your home and install low VOC wood or tile flooring.
  29. Eat grass-fed beef, free range, hormone free and antibiotic meats and eggs
  30. Cook with electric stove and oven and remove gas stove and oven.

UPDATE November 25, 2014

PREVENT SIDE EFFECTS caused by methylfolate.

Read this article first before taking anything else, unless recommended by a health professional. Preventing Methylfolate Side Effects.

General Nutrient Recommendations for C677T MTHFR mutations:

  • Methylfolate
  • Methylcobalamin
  • Betaine in the form of TMG
  • NAC
  • Glutathione
  • Pyridoxal-5-phosphate
  • Riboflavin
  • Curcumin
  • Mixed tocopherals (vitamin E)
  • Silymarin (Milk Thistle)
  • Phosphatidylcholine
  • Nattokinase
  • Vitamin C
  • Vitamin D3
  • Comprehensive multivitamin/multimineral
  • Probiotics

Typical Pharmaceuticals Recommended for the C677T MTHFR Mutation
There are many pharmaceuticals commonly recommended for C677T MTHFR mutations yet they are ill-advised as they contain inferior forms of vitamin B12, little or no vitamin B6 or the incorrect form of folic acid.

It should also be known that all pharmaceutical drugs below contain food coloring, dyes, anti-caking agents or other compounds that should be avoided.

  • Deplin 7.5 mg or 15 mg (don’t recommend this often at all – very rarely)
  • Cerefolin NAC
  • Metanx
  • Lovenox
  • Baby aspirin

Compare the drugs used for MTHFR mutations here

Prenatal Recommendations for MTHFR C677T Mutation
A quality prenatal for those with this defect requires methylfolate, folinic acid and no folic acid. These prenatals are very hard to find. There are quality prenatals out there but many have only folinic acid which is not effective for those with C677T mutations. Methylfolate is needed to bypass the MTHFR mutation and folinic acid is needed in case there is any MTR/MTRR inhibition for any reason – along with other folate snps beyond MTHFR.

Read the Prenatal Supplement Suggestions article for more information

General Supplements which Dr Lynch Recommends for MTHFR C677T Mutations
While these are the general supplements recommended by Dr Lynch, he never recommends taking them all right away.

Begin by taking the most important one first (depends on the individual) in a small amount for at least a few days to see how you respond. If you respond well, continue taking it and add in another supplement.

This way you can easily identify if a specific supplement or nutrient is giving you problems.

In general, those with C677T mutations have decreased ability to produce methylfolate, increased cardiovascular risk, increased risk of blood clots, increased pain and inflammation and increased chemical sensitivity. Recommendations below support the reduction of these issues by increasing the body’s inherent ability to restore function through nutritional biochemistry.

NOTE: If you are not sensitive to supplements in general, then it is recommended to start with a comprehensive multivitamin and multimineral as this supports numerous biochemical functions within your body. It also provides a fast testing ground to see if you respond well to numerous nutrients.

If you do not tolerate a multivitamin well, this is a sign that you must proceed more slowly and work on healing your digestion and dietary intake and lifestyle habits first.

  • Optimal Multivitamin line
    • contains methylfolate and methylcobalamin
    • no folic acid
    • comprehensive and well-absorbed minerals
    • all B vitamins in quality forms
    • comes in three forms:
      • Optimal Multivitamin
        • Ages 16 and up: consider 3 capsules with breakfast and 3 capsules with lunch
        • contains 400 mcg of methylfolate
        • iron-free
        • free of magnesium stearate, flavors, titanium dioxides
      • Optimal Multivitamin Chewable
        • Ages 4 and up: consider 1 tablet with breakfast and 1 with lunch
        • contains 400 mcg of methylfolate
        • easy delivery and well-tolerated
        • may give to younger children (2 and above) with doctor’s permission
        • 2 mg of iron per chewable tablet
      • Optimal Prenatal
        • useful for preconception, pregnancy and breastfeeding
        • contains 800 mcg of a blend of methylfolate and folinic acid
        • comprehensive B vitamins and chelated minerals
        • iron-free
        • specialty nutrients to support neurological development and ease morning sickness
      • Kid’s Optimal Multivitamin
        • Ages 4 and up: consider 3 capsules with breakfast and 3 with lunch
        • smaller capsules easier to swallow
        • iron-free
        • free of magnesium stearate, flavors, titanium dioxides
  • Optimal Vitamin E
    • contains 400 IU of mixed tocopherals
    • supports a healthy cardiovascular system
    • learn about mixed tocopherals here
    • consider 1 capsule daily
    • if on blood thinning medication or have bleeding disorders, talk with your doctor before taking vitamin E
  • Liver Nutrients
    • supports liver detoxification
    • has NAC, Methionine, TMG, Cysteine, Alpha Lipoic Acid
    • has 80% of 200 mg of active silymarin per serving
    • consider starting with 1 capsule per day WITH DINNER
    • always take WITH A MEAL – not a snack
  • Optimal Turmeric
    • supports reduction in inflammation
    • liposomal form of curcumin providing higher absorption and effect
    • consider starting with 1 capsule with a snack before bed
    • increase to 2 capsules three times daily during times of high inflammation or pain
    • protect your nerves, brain and blood vessels by decreasing inflammation
  • Flow Fx
    • supports reduction in fibrin which is material found in blood clots
    • useful for supporting healthy blood flow and circulation
    • do not use if using other blood thinners such as Lovenox or baby aspirin
    • consider taking 1 capsule every 12 hours
    • this is likely not needed for heterozygous individuals unless other clotting disorders are present.
    • NOTE: nattokinase has not been proven to be more effective than baby aspirin, coumadin, warfarin or other clot-prevention drugs. Caution is advised.
    • if you are high-risk for blood clots, then pharmaceutical drugs are recommended over nattokinase.
  • ProBiota 12
    • supports healthy bacteria in digestive tract
    • provides 25 billion bacteria in 12 strains per capsule
    • necessary to strengthen immune system which is weakened in MTHFR mutations
    • consider taking 1 capsule after dinner nightly
  • Liquid Vitamin D360
    • supports healthy immune function
    • provides support for healthy bones and hormone formation
    • supports healthy mood and neurotransmitter production
    • each drop provides 2,000 IU of vitamin D3
    • in a base of extra virgin olive oil
  • Optimal Krill Oil
    • provides potent antioxidant support which is needed in toxic individuals
    • supports a healthy brain and nerves as krill oil penetrates the nerves and brain better than fish oil due to the natural phospholipid structure
    • consider taking 2 capsules daily with a meal anytime of day
    • naturally more pure than fish oil
  • Neutralize
    • provides buffering agents to neutralize side effects from environmental exposures
    • consider taking 1 capsule upon the onset of undesired symptoms from an environmental exposure
    • contains 125 mg of potassium per capsule so take caution if on potassium medications or having arrythmias
    • assists in reducing stomach acid/reflux symptoms

How much methylfolate to take?
This is the big question that is asked all the time.

Experience demonstrates that those with 1 copy of the C677T MTHFR mutation do not need much methylfolate beyond what is found in the Optimal Multivitamin line.

The MTHFR enzyme is working at nearly 70% or so effectiveness in heterozygous individuals while in homozygous individuals, it is working at only 30% effectiveness (The effectiveness percentage varies from paper to paper. Currently evaluating the research).

Individuals who are homozygous for the C677T MTHFR mutation do need more methylfolate than what is in the Optimal Multivitamin line.

To determine how much more methylfolate you need, it is best to start low and work up. This allows you to safely identify how much you tolerate without triggering very undesirable side effects.

If you are heterozygous for the C677T MTHFR mutation, the recommendations below are likely not needed. You are welcome to try them but it is highly encouraged that you proceed cautiously in order to prevent side effects from excessive methylfolate.

NOTE: If you begin supplementing with methylfolate and you have inflammation unchecked, your symptoms may worsen. This is why it is critical that you are tolerating and taking probiotics, krill oil, turmeric along with improving your diet and lifestyle first.


Methylfolate Recommendations for those homozygous for the C677T MTHFR Mutation:
Once you have determined you respond well to the probiotics, krill oil, turmeric and vitamin E, then you may proceed to slowly adding the following.

Methylfolate is best absorbed on an empty stomach or sublingually.

  • Active B12 5000
    • provides 5,000 mcg of methylcobalamin per sublingual tablet
    • important to supply methylcobalamin first before methylfolate to prevent methyl trapping
    • break the tablet into fifths and place 1/5th under the tongue upon waking
    • do this for 1 week to see how you feel
    • if you feel well, proceed to switching to 1/4 tablet of Active B12 with Methylfolate
    • if you do not feel well, stop taking it and switch to taking 1/2 capsule of L-5-MTHF
    • if you do not feel well taking 1/2 capsule of L-5-MTHF, stop taking it. You are either receiving sufficient methylfolate at this time or you are not yet prepared to take it due to other mutations present or other health issues worsen from methylfolate.
  •  Active B12 with Methylfolate
    • provides 1,000 mcg of methylcobalamin
    • provides 800 mcg of methylfolate
    • sublingual tablet provides effective absorption of both nutrients
    • break the tablet into quarters and take 1/4 tablet upon waking for a few days.
    • if not well tolerated, cease the use. You have to back up and heal your digestion further and identify other issues before addressing the MTHFR mutation
    • if well tolerated, increase to 1/2 tablet upon waking for a few days
    • as you tolerate it and feel improvement, keep increasing by 1/4 tablet every three days.
    • once you reach 1 full tablet in the AM and tolerate it well, stop the use of Active B12 with Methylfolate and switch to HomocysteX.
  • HomocysteX
    • provides 800 mcg of methylfolate, 1000 mcg of methylcobalamin and 25 mg of pyridoxal-5-phosphate
    • provides further support in lowering homocysteine and producing glutathione through pyridoxal-5-phosphate
    • upon waking, consider taking 1 capsule of HomocysteX with a glass of water.
    • if not well tolerated, you may have a CBS mutation or COMT/MAO A mutation. Stop the use of HomocysteX and return back to taking 1 tablet of Active B12 with Methylfolate as you were.
    • if well tolerated, stay on 1 capsule of HomocysteX for 1 week.
    • if improving, consider adding in a 1/2 capsule of HomocysteX 30 minutes before lunch for one week.
    • if well tolerated, consider taking a full capsule of HomocysteX upon waking and also before lunch for one week.
    • each week, if well tolerated and feeling improvement, keep increasing by 1/2 capsule.
    • if well tolerated at 2 capsules upon waking and 2 capsules before lunch, cease the use of HomocysteX and switch to HomocysteX Plus
  • HomocysteX Plus
    • provides similar nutrients as HomocysteX with the addition of riboflavin-5-phosphate and betaine as TMG.
    • provides further methylation support and homocysteine-lowering nutrients
    • consider taking 1 capsule of HomocysteX Plus upon waking for a week.
    • if not well tolerated, stop the use and return back to HomocysteX.
    • if improving after one week, consider adding in a 1/2 capsule of HomocysteX Plus before lunch for one week.
    • if well tolerated, consider taking a full capsule upon waking and a full capsule before lunch.
    • each week, if well tolerated and feeling improvement, keep increasing by 1/2 capsule.
    • it is not expected to increase beyond 2 to 3 capsules upon waking and 2 to 3 capsules before lunch.
  • Active B12 5000
    • Once you discover which methylfolate supplement you tolerate best: Active B12 with Methylfolate, HomocysteX or HomocysteX Plus, then work on adding in additional methylcobalamin via Active B12 5000.
    • Upon waking take 1/2 tablet of Active B12 5000 in addition to your chosen methylfolate supplement.
    • Do this for 1 week.
    • If well tolerated, take a whole tablet sublingually of Active B12 5000 upon waking in addition to your chosen methylfolate supplement.
    • Typically, only 1 tablet of Active B12 5000 is needed by most individuals; however, some autistic children or those with MTR/MTRR genetic defects require additional methylcobalamin.
    • Continue increasing by 1/2 tablet of Active B12 throughout the day – but not past 1 pm as it may inhibit your sleep.
    • Up to 4 tablets may be taken daily – ideally spread throughout the day to increase absorption – but again – not after 1 pm.

Methylfolate Side Effects
These are common despite what physicians may inform you.

Common undesirable side effects of methylfolate must be identified.

  • headache
  • migraine
  • rashes
  • irritability
  • anxiety
  • joint pain
  • muscle pain
  • insomnia
  • depression

If side effects occur, then the amount of methylfolate you are taking needs to be taken under consideration and likely reduced. Talk with your physician before altering any protocol or supplement/pharmaceutical.

Many times one is not yet ready to take methylfolate.

There are other steps that must be taken prior to supplementing with methylfolate if these side effects occur.

If side effects occur, taking Niacin helps bind the excessive methyl groups which are likely causing the issue. Consider taking 100 mg or 1/5th tablet of Niacin if these symptoms occur. It is a good idea to have a bottle of Niacin on hand in case these symptoms occur from taking too much methylfolate. Be sure to swallow the 1/5th tablet of niacin – not chew or place sublingually.

Flushing is common from taking niacin in the most active form, nicotinic acid. This is not harmful and will subside in about 20 to 30 minutes.

Do NOT take a full tablet of Niacin. Begin by taking only 1/4 a tablet.

Cycling Supplements for Methylation Balance
Supplements and pharmaceuticals such as HomocysteX Plus, HomocysteX, Cerelin Forte or Metanx are designed to support methylation.

It is methylation that is severely disrupted in those with C677T MTHFR mutations – especially homozygous individuals.

Methylation requires balance.

If methylation becomes excessive, side effects will occur as noted above. This requires adjustment in your protocol.

There is a need for routine adjustment as our bodies are dynamic.

If you feel the side effects above, it is recommended you notify your physician and have them make adjustments.

For example, these adjustments may range from:

  • stopping all methylation-supportive nutrients
  • taking these nutrients 4 days on and 3 days off
  • taking them every other day
  • taking them only in the morning
  • decreasing the amount taken every other week

General Side Effects
If you are feeling improvement consistently, then you are on the right track.

If you begin to feel heavy, tired, dry mouth, irritable, ‘toxic’, or otherwise ‘not right’, then something in your protocol needs to change.

These are all signs that one must listen to otherwise you are potentially increasing the circulation of toxins and not eliminating them properly.

These side effects can be eliminated quite quickly through a pure vegetable and fruit juice diet for at least one day. This means producing your own juices at home via a quality juicer such as Champion Juicers. Prepare mostly vegetable juices with some fruit juices to increase the taste.

Taking a capsule of Neutralize or some Niacin also helps offset many side effects.

The above recommendations will help a majority of individuals who have heterozygous and homozygous C677T MTHFR mutations.

In the event you are stuck, consider obtaining a copy of the Folate Metabolism and MTHFR Video Presentation.

I highly encourage that you locate a physician with training in this complicated – yet amazing – area of medicine.

Visit the Physician Directory at Seeking Health Educational Institute to find a health professional near you.

Comments are welcomed below.

Share your thoughts, feedback and how you are improving from these recommendations.


520 Responses to “MTHFR C677T Mutation: Basic Protocol”

  1. Kathy February 25, 2012 at 2:32 pm # Reply

    Dr. Ben, Thank you so much for your website!! This is the most comprehensive site I have found for information on mthfr and it gives me hope and comfort knowing I am not alone in this. I have been looking for a protocol being homozygous c677t. I was diagnosed 8/2011 and it has taken awhile for me to come to terms with this and find resources to help me with my journey. Your information and presentations are very easy for me to understand. I have already asked a question which you promptly answered, I took the survey and I want to do a consultation. I just wish I would have known about my mthfr when I was younger, it would have saved me so much of my life. I always knew there was something wrong but, every Dr. I went to made me feel like I was crazy. I really feel if I had an early diagnosis and treatment I could have been a better daughter, sister, friend, wife, and mother because I would have been present!!
    I am going to start experimenting with the protocol, some of which I am already taking,
    and feel hopeful for the first time. Again, thank you!!

    • Dr Ben February 27, 2012 at 5:25 pm # Reply

      Kathy –

      Excellent to hear that you are feeling positive – that is key ;)

      Remember – start slowly and ease into it.

      I really want people to understand this point. If people try to reverse a lifetime of symptoms by swallowing a ton of supplements in high amounts, it is definitely going to backfire.

      One at a time and evaluate. Then increase the amount taken if needed.

      Keeping a journal is helpful!

      Keep us posted how you improve!

      Try working through the suggestions above and if you hit a wall or not improving, that is the perfect time for a consult. Check our Find A Doctor page for a physician or practitioner near you.

      • Kathy February 28, 2012 at 4:06 pm # Reply

        Dr. Ben,

        Right now I am just tolerating 200mcg. of methylfolate. I feel some anxiety and flushing, I am going to take it slow. I was wondering about having my amalgams removed and when would be a good time, before ,during or fully methylating . I don’t want to make matters worse. I also would like to take a multi-vitamin mineral without the methylfolate until I can tolerate more. The one I have been taking has 400mcg of folic acid!! Any suggestions.

        • Dr Ben February 28, 2012 at 6:09 pm # Reply

          Kathy –

          Great question on the amalgams.

          It is important you heal your gut first and feel some improvement there before removing your amalgams.

          Then, once that occurs, you must go to a biological dentist who understands how to properly remove mercury from the mouth.
          – Dams in place
          – IV vitamin C
          – air filtration

          How you getting the 200 mcg of methylfolate? Where is that coming from?

          I recommend stopping that and taking 2 capsules of Optimal Multivitamin with breakfast and 2 capsules at lunch.

          This amount will provide 200 mcg of methylfolate while providing numerous other B vitamins and minerals.

          • Kathy February 28, 2012 at 11:35 pm #

            Dr. Ben,

            The source of my methylfolate is Solgar Folate 800mcg as metafolin. I cut the pill into fourths to see how I reacted to it. Optimal Multivitamin sounds perfect, I saw it in the protocol but didn’t understand the dosage.
            Thank you!!!

            I have been doing work on my gut with an alternative Dr. however, he doesn’t have much to say about mthfr. I just did a dmps chelation and will find out soon what toxins are present and go from there!

            Thank you so much for your time and expertise!

    • Rob Johnson September 18, 2013 at 4:42 pm # Reply

      Dr Ben
      Recently shown to be homozygous for MTHFR C677T. So is my brother which is the question. He is diagnosed with ALS and is gradually weakening, cannot use his tongue to speak and needs help to walk. He is undergoing chelation from extremely high levels of lead, arsenic and mercury. We grew up across the street from a refinery in the 50’s – 70’s when releasing gases into the air was common. Is he too far advanced for Part 2 treatment listed above to help?

      • Pam Dalton January 17, 2014 at 7:04 pm # Reply

        Hi Rob and Dr. Ben,
        I just found out that I am hetero for C677T, and A1298C, and others, and homo for MAO-AR297R. Also, I have chronic late stage Lyme, Hashimotos,pernicious anemia, and many others. It’s very hard to know what is affecting what. I wanted to mention to Rob that I had a support group for people with chronic illnesses for several years. We had several ALS people in the group, as well as MS, RA, lupus, FMS, CFIDS, etc. Once I found out that I had Lyme(was born with it), most of the others got tested, and over 80% ended up positive for Lyme, including the ALS folks. I know there are different strokes for different folks, but I did want Rob to know of that possibility.

    • Lavon January 18, 2015 at 9:05 pm # Reply

      Kathy I just found out i have this, im 55, & severe issues.
      I too feel always sensed there was something wrong & know
      I could have been better to all if this was caught & treated properly
      earlier. Im deviststed & life a mess. Now am searching for best
      treatment all alone, its only been a few days, uncountable drs
      never picked this up. A Nurse Prac. ran the test & caught it but just told me
      to take methylated folic acid-off on wild goose chase as
      not many places carry it. I am quite advanced- major attention probs,
      scared alone. Not sure NC knows how to treat it even tho she
      found it. Would welcome any support, thanks, L

      • Angela February 8, 2015 at 4:52 pm # Reply

        All of my 3 living siblings and I have been diagnosed as having a double copy of the C677T variation, meaning our parents each have at least a single copy. My older brother commited suicide 1.5 years ago after suffering from immune deficiencies, schizophrenia and depression. My younger sister has been diagnosed with Multiple Sclerosis, my younger brother has ADHD and youngest brother is Down’s Syndrome. My grandfather on my mother’s side has severe OCD, and grandmother had immune deficiencies, colon cancer and diabetes. On my dad’s side, his father has a history of heart problems and arthritis, and his mother has arthritis and had great difficulty conceiving. My own mother and father have no aparent side-effects besides their difficulty conceiving, which didn’t stop their having 5 naturally born children. I have no side effects, but notice the use of the methylfolate and B-12 sublingual supplement improves my focus. While it is life-changing, it gave us a peace of mind to know the truth. And knowing how much improvement the supplements have made in my siblings makes me wish we knew about it for my older brother. But, while it is a hard realty to cope with and may change some things, it is part of what makes you the beautifully unique person that you are, and cannot stop you from dreaming, attaining your dreams and blessing those in your life with your presence. It is a diagnosis. It always was. It is you. While it is hard to accept, there are so many people in the world who carry this weight but do not know it. You can be the carrier who knows what you carry and carries it gracefully. You are troubled, but your troubles have already been your strength to have gotten you this far. I hope you may find peace with yourself, and become ready to accept the next challenge in your life, whatever it may be. You can do it!

        • Mel March 5, 2015 at 7:54 pm # Reply

          Thank you for sharing your story. I’ve had some similar experiences in my family. Can you tell me if you and your siblings saw a specialist or if you supplemented on your own? We’ve already spent thousands of dollars on medical care that was not covered by seeing holistic or integrative doctors, and I’m not sure we can continue doing that. I would really like to address our MTHFR mutations. Thank you so much!

  2. Maggie February 28, 2012 at 10:39 pm # Reply


    I am homozygous for C677T. I had a TIA in 2009 resulting in a blind spot in my right eye, which is what led us to elevated homocysteine levels of 31. The previous 3 years had seen several miscarriages. I also have Lyme disease that is not active.

    My current protocol is 4mg Folic Acid, 1 baby aspirin (increased to 1 full aspirin during travel or long periods of sitting), and pre-natal vitamins. On my own, I have added Vitamins D & C, Magnesium, Zinc, Omega 3, trace minerals, and kelp.

    I consider myself flirting with Veganism, and 85% of my meals and days are vegan, though occassionally I will allow myself good (grass fed, free range, mostly local) meat, or good cheese. (I am a foody at heart). I eat leafy greens daily, a lot of them, which are high in folate.

    My homocysteine levels are presently 15, down from 31.

    I drink wine. 1-2 glasses a day, sometimes more if I go out and I smoke 1-2 cigarettes 4-5 days a week (but not 7 days).

    After my diagnosis, I carried a pregnancy to term. I was on Lovenox 2x a day during my pregnancy, and gave birth early at 34.5 weeks due to partial placental abruption that resulted in an emergency c-section. The increase in my FA was what I attribute to me carrying a pregnancy to term as it was the only thing in my protocol that changed.

    I am curious about what you think of my situation and what you think I should be doing differently.

    • Dr Ben February 29, 2012 at 12:02 am # Reply

      Hi Maggie –

      Congrats to carrying a baby to term.

      MTHFR is linked to placental abruption as you may know.

      I would rather see you taking the more active form of folic acid which is methylfolate.

      Folic acid does get converted to methylfolate but very little in those with two C677T alleles.

      If your methylfolate levels were higher and you were taking CoQ10, you may have reduced your risk of placental abruption.

      Your diet sounds good right now – I would not become a vegan as it is impossible to get your methylcobalamin as a vegan and it is also harder to maintain iron levels.

      If you can focus on stopping wine and smoking – that would be ideal.

      • Maggie February 29, 2012 at 11:55 am # Reply

        Curious about your argument for stopping wine and smoking. No doctors seem to give me concrete answers for this other than it is best for optimal health. I know that smoking has been proven to raise homocysteine levels but there is no concrete evidence about it in moderation, and wine has actually been proven to reduce stroke risk.

        • Cal March 27, 2013 at 1:02 pm # Reply

          Why even bother doing everything you are doing if you are going to smoke?

        • Marsha August 10, 2013 at 1:26 am # Reply

          I agree with Cal. With all due respect Maggie, you sound like you’re in complete denial. Why not give just cut out the middleman and give the baby some cigarettes and wine?

          By the way, it’s been shown that the reason wine may reduce stroke risk is because of the resveratrol from the grape’s skins.

          • Richard March 13, 2015 at 2:29 am #

            If u desire heart trouble, breast cancer ostioperosis and eye problems; by all means-keep on smoking and drinking your wine. Wife has had all the above and quit; she is still with us due to the fact she would rather live than smoke or drink wine. After three years we are both glad that the vices have let us continue on God’s path for our life. We wish u well, as the world is full of pleasant little traps that could just kill you. First, be well; as Bruce Lipton says, your belief system runs (manages) your genes.

        • Dr Rhonda Simons November 27, 2014 at 5:16 am # Reply

          First, Maggie, you need to find out your Apo E genotype. If you are a 3/4 or 4/4, you should avoid alcohol completely, as it raises your LDL and lowers your HDL, increasing your CVD risk. ALL data has shown that alcohol during pregnancy could cause FAS. If you want to play with lowering your kids IQ, and you already have MTHFR, you are also looking at PDD & ADD. AFTER the pregnancy, 1 glass for a woman (if you are not a 3/4 or 4/4) every other day CAN increase your HDL and reduce risk of CVD. It doesn’t matter if it’s wine, liquor, or beer. It’s the effect of the alcohol. Some people do better with red wines, some get headaches.

          Smoking is an ABSOLUTE NO when pregnant, especially as a MTHFR because we clot worse anyway. Smoking increases the risk for placental abruption and clots in the placenta which causes fetal demise in utero. Just say NO, if you are having trouble try a Nicotrol inhaler. Then you can just use it when you need it. Hold the vapor in your mouth, as it is not absorbed by the lungs. Nicotine is STILL harmful to a pregnancy, but not as much as regular cigs.
          Rhonda Simons, DO

    • Judy March 14, 2015 at 12:51 pm # Reply

      Hi Maggie,

      I don’t know why they all picked on you after mentioning ciggies and wine when pregnant. No-one has the right to judge. It sounds like you are doing your best with everything else and not many people are 100% successful at anything. I quit smoking for 2 years even through a severe mental breakdown caused by inexplicable anxiety feelings even about deciding which clothes to wear…it was just plain everything. Yet I managed to stay off the cigs and I vaped with barely any nicotine in the ecig and even quit the nicotine juice completely but I was put on Effexor by then in preference to the shock treatment they offered. The anxiety eventually lessened but I was aware I was also depressed. I still vaped instead of smoking. I still had the self-discipline but it did not last. I had a smoke when a friend came over and that lead to three because for the first time in….I don’t remember……I enjoyed something. I actually enjoyed the head spin and I giggled with my friend. It was not more than a month or two before I was buying my own. The anti-depressants kept on making me happier and and I was on a high just enjoying doing nothing but feeling how nice it was to feel calm again….and the cigarettes. Food tasted great now and although I did not know what to do with my life, I did not worry about it. In fact I didn’t care. I still don’t. I play computer games which I never could abide by before. I chain smoke. Go to the beach when I feel like it and I take my Effexor because if I miss a dose by even half an hour my head starts feeling weird. There is no such thing as anti-depressant withdrawal they say, but I think it is a lie. This has happened to me before and it progressively gets worse. And I think these SSRI’s and SNRI’s in particular have a bad effect by inhibiting self-control after you have been on them a while and what ever else that seems to be making me more hedonistic and less concerned about others. Is that what it feels like to not have anxiety any more? Or has this gone over the top because of long-term Effexor? I don’t know. But how do I stop smoking when I don’t even care enough to try? I’m just enjoying it. Dumb story I know but everyone has their story even those who don’t smoke.

      Maggie is doing pretty darn well looking after herself and her baby. She has applied a lot of learning and I for one wish her all the best. And for the record. I smoked through my first pregnancy and the baby was 9lb 2oz. It was the hospital that gave him giardia not me. And it was the doctors who told me to stop breastfeeding because of a lactose intolerence not me nor the nursing mothers association. It was not me who did most of the damage in those early months.

      Maggie will do what she does just like the rest of us. She may decide to stop smoking etc but it has to be her decision because there is no sustaining motivation unless it comes from within. I hope I get it back. Maybe I will try switching anti-depressants. Whatever I decide to try do or not do, it is none of anyone else’s business unless I ask for advice. Don’t judge Maggie. You can judge me now.

  3. Catherine March 1, 2012 at 6:28 pm # Reply

    “Have one or two copies of the MTHFR C677T mutation?

    Don’t know what to do?”

    Yes and yes, and I don’t know what to do. I am homozygous (with normal homocysteine levels) but a healthy, happy, and fit 44 year old who takes a dose of baby aspirin daily and super B vitamins. Is there something wrong that I don’t know about? Your entire website suggests that there might be. Is it possible to be homozygous and be completely normal??? I don’t have any digestive issues, other than occasionally. Is there something I should be watching out for? What do doctors need to know before prescribing medication or taking some course of medical action? I cannot find the answers to these questions on your site.

    (I have had miscarriages, which is how the mutation was discovered. But I did carry 1 child to term and am blessed with a happy and healthy 5-year-old now. I do not want more children.)

    • Dr Ben March 1, 2012 at 7:21 pm # Reply

      Hi Catherine –

      If you have no symptoms and are taking baby aspirin and quality B vitamins which have methylfolate, then you are doing well.

      The fact that you miscarried in the past does show some potential link between the MTHFR C677T homozygous – but of course cannot be positive in your situation as there are plenty of other factors.

      In your situation, I would simply recommend the basics:
      – Optimal Multivitamin: 3 capsules twice daily with meals – breakfast and lunch
      – ProBiota 12: 1 capsule after dinner
      – Optimal Vitamin E: 1 capsule with food
      – Vitamin D360: 1-2 drops daily
      – Liver Nutrients: 1 capsule after dinner
      – Optimal Fish Oil: 2 capsules with food anytime

      Then possibly add:
      – Sublingual Active B12 with Methylfolate: start with 1/4 tablet for a few days and increase if you feel improvement.

      Those are the basics needed for C677T homozygous.

      The fact that your homocysteine levels are fine is great – but MTHFR C677T is much more than just homocysteine. It is about DNA repair, detoxification, neurotransmitter support, immune support to name a few.

      If your child has any symptoms, I recommend getting him tested – and tell your immediate family that they should test for it as well given that you have two mutations.

      At this point, you want to reduce your risk of cancer, support DNA repair, support detoxification and support your immune system. You need to optimize.

      Doctors typically do not optimize and our health care system is actually a ‘sick care’ system. There is very little prevention done.

      It is not possible to be homozygous C677T MTHFR and be completely normal if you are not taking methylfolate. When I say, ‘normal’ I mean your biochemistry is not fully functioning like it should.

      If you eat a diet FULL of uncooked dark leafy vegetables and uncooked lima beans (highest in folate and don’t recommend it), then the likelihood of your methylfolate levels being normal are possible. Without testing for methylfolate levels, it is impossible to say.

      Cooking vegetables or processing them destroys the food folate so very little is remaining.

      You can ‘force’ normal levels of methylfolate by taking high doses of folic acid but I do not recommend that. Higher doses of folic acid have been shown to support the growth of pre-existing cancer cells. This is why I recommend food folate and methylfolate – especially in those with the C677T homozygous alleles.

      • Catherine March 1, 2012 at 7:57 pm # Reply

        Thank you very much for your thorough reply. I am sure it will help others who, like me, call themselves “normal.” I agree with your assessment of the American health care system. Two more questions:

        1. Recently I read about possible consequences of the use of nitrous oxide on patients homozygous MTHFR C677T. My question is how does one talk to physicians about the mutation? I don’t even know where to begin. Because it was only discovered in 1995, it seems there aren’t protocols in place or physicians who are aware.

        2. How can I get my 5-year-old daughter tested? Is it something that a pediatrician would do if requested? I’m afraid I would encounter resistance and possibly a mention of insurance issues (I do have very good coverage, however). After all, I only got my test after 3 miscarriages. Lucky me.

  4. Tiffany March 2, 2012 at 12:22 am # Reply

    My daughter and I are heterozygous C677T. I take Methyl Guard from Thorne Labs (as advised by my dr). How do you feel about this supplement? My daughter is only 2 but has a speech delay and I’m fearing a PDD diagnosis. Do you have a protocol for children? Thanks!

    • Dr Ben March 3, 2012 at 12:26 am # Reply

      Tiffany –

      Methyl Guard is good. It is very similar to HomocysteX Plus by Seeking Health but the amount per capsule is different.

      For a heterozygous MTHFR C677T mutation, I do not recommend very many capsules of Methyl Guard or HomocysteX Plus as you may get side effects.

      The protocol for children I have not yet made available online.

      Speech delays have many causes –
      1) iron deficient anemia,
      2) b12/folic acid deficient
      3) EPA/DHA deficient
      4) thyroid dysfunction/low iodine
      5) not being around enough children which encourages her to communicate.
      6) metals/toxicity

      Do you suspect any of these? Have lab testing for her?

      I would not use Methyl Guard or HomocysteX Plus for your daughter.

      If you are breastfeeding still, she will get nutrients from you this way.

      • Tiffany March 3, 2012 at 1:05 am # Reply

        We are no longer breast feeding. Her eye contact and speech seemed to worsen when we stopped so i thing the MTHFR may have something I do with it. I think she is borderline PDD. I have been givin her methyl B12 drops and cod liver oil for a Long time, but she does not eat much meat or greens so she could be anemic. Her multivitamin has folate (regular) and iodine (not much). She had never been vaccinated, eat no seafood, and i have have no amalgeam fillings and rarely ate seafood while pregnant so i doubt metals. I suspect perhaps a yeast overgrowth as well (she is taking probiotics). I have not lab tested any of these. I have an appointment with her doctor (aware of the mutation) next week and will discuss these thoughts with her. Do you know I any powder/liquid methyl folate products I could give her? I mix everything into her drinks.

        Any suggestions are eagerly awaited. Thank you!

      • Andrea September 9, 2013 at 5:39 am # Reply

        When you say you don’t recommend very many capsules of the Methyl Guard, how many is that? The label recommendation says 3 capsules twice a day = 6 capsules per day.

  5. Kathy March 3, 2012 at 4:56 pm # Reply

    Dr. Ben,

    Seems like I keep hitting roadblocks!! You recommended Optimal multivitamin for my homozygous c677t protocol two with breakfast and two with lunch to start however, the results from my IgG Food Antibody Assessment shows a high intolerance to garlic. The Optimal multivitamin has 50 mg of Pure-Gar- odorless. Do you think that amount of garlic would be okay or is there another product without garlic. The only reaction I ever realized I had with garlic was indigestion if I ate to much. I really want to get back on a multivitamin mineral soon. Thanks for all your help!!

    • Dr Ben March 3, 2012 at 11:52 pm # Reply

      Kathy –

      I don’t trust that on the food allergy panel with garlic. That seems odd to me. Food allergy testing is very iffy anyhow. I don’t like using it. I prefer doing food elimination diets.

      If you find that you only had indigestion from garlic, do consider trying Optimal Multivitamin.

      If you like, you can also take the Optimal Multivitamin Chewable – and chew two tablets twice daily. This is garlic free and also contains methylfolate and methylcobalamin.

    • Alisa August 20, 2014 at 11:51 pm # Reply

      I have multiple b reactions to garlic, email years of experimenting after IgG. Numb tongue, sore throat for 1.5 days and night sweats. I believe garlic chucks make me up chuck violently, thus have avoided them for 8 years. I get painful itching when exercising, with my recent c677 positive test, I think they are related. Undigested food proteins, maybe especially Garlic protein stuck in my capillaries. Any thoughts?

      • evy August 21, 2014 at 2:02 pm # Reply

        Your sulfur pathways may be amok (my daughter has issues with onion, garlic, etc. and gets an instant headache, stiff neck, foggy brain and feels HORRID on even smelling an onion or garlic being cut, let alone cooked). So, for all the benefits of garlic, it’s apparently not a go in our house :(

  6. Allison March 7, 2012 at 5:27 am # Reply

    Hi Dr. Ben,

    Thank you for publishing the protocol suggestion and for the site itself.

    Are you able to include some rationale for the suggestions as most with chronic illness are on a very limited income. Obviously the methyl B12 and 5MTH are self explanatory.

    I’m particularly interested to know what the Betaine TMG and nattokinase are good for in regards to MTHFR SNPs. I am homozygous for C667T, not sure of A1298C as the lab didn’t test that one. I am just about to submit my sample for the Amy Yasko methylation panel so will know more in a few months.

    Do you think C667T is a part of chronic fatigue syndrome or is A1298C more likely to be CFS related?


    • Allison March 7, 2012 at 11:47 pm # Reply

      Also, can you be more specific about the methylfolate dosage range for the homozygous C667T? Would like to know what dosage ranges have been used. I started at 200mcg and slowly worked up to 1mg but feel I have more improvement to make but don’t know what an upper limit would be?


      • Dr Ben March 8, 2012 at 12:09 am # Reply

        Allison –

        Upper limit is the amount of methylfolate that is bringing you health without side effects.

        If you are feeling well, keep increasing the level of methylfolate slowly. In time, you will find the amount that is good for you.

        If you want to proceed faster, you may but be aware that you may get side effects.

        I know some doctors recommend 10 mg of methylfolate right out of the gate – or even 15 mg as with Deplin 15 mg.

        I prefer not to do this as I don’t like it when side effects occur.

        Also make sure you are taking methylfolate. If you are not, the methylfolate may be getting trapped and not doing anything. This is why I recommend Active B12 with Methylfolate.

        • Lynn_M March 8, 2012 at 4:55 am # Reply

          Dr. Ben said: “Also make sure you are taking methylfolate. If you are not, the methylfolate may be getting trapped and not doing anything. This is why I recommend Active B12 with Methylfolate.”

          I believe you meant to say: make sure you are taking methylcobalamin.

          • Mirjam September 4, 2014 at 1:16 pm #

            Hi Lynn,

            I am searching for more info on what to do when you are under the effect of methyl trapping. Do you have any idea? I am very desperate as my cognitive function is decreasing very rapidly and I don’t know what to do.

            I made the stupid mistake of taking 1000mcg Methylfolate without additional Methylcobalamin (maybe a tiny bit from food). I experience severe brain fog and mental dysfunctioin, memory loss, confusion.. it’s horrible. Do you think I should stop taking Methylfolate and start a high dose of Methylcobalamin? Maybe I need Niacin? I would be extremely grateful to get a reply. Many many thanks in advance.

            Grtz Mirjam

        • Allison March 8, 2012 at 8:34 am # Reply

          Thanks Dr. Ben,

          Much appreciated. I am taking 5mg of methylcobalamin and have just increased my 5MTH (methylfolate) to 1.4mg.

          I had a couple of other questions in my previous post if you have time to briefly touch on those?


        • Mirjam September 4, 2014 at 1:30 pm # Reply

          Dear Dr. Ben,

          You mentioned here that you should always take methylcobalamin with the folate. Unfortunately I read that way too late. In another reply you mention methyltrapping. If I understood correctly that is what I am experiencing now.
          I made the stupid mistake of taking 1200mcg Methylfolate for a while without additional Methylcobalamin (maybe a tiny bit from food).

          Now I experience severe brain fog and mental dysfunctioin, memory loss, confusion.. I cannot study anymore and find myself really sad. At first I thought I had a brain tumor.. it’s really horrible. Now I take 400 mcg Methylfolate and 500 mcg Methylcobalamin for weeks but I really don’t feel any better. Should I stop Methylfolate for a while? Do I need to take Niacin in this case as well? I cannot find any usefull information anywhere on the internet on methyl trapping and especially on what to do about it.

          I would be extremely grateful to get a reply. Many thanks in advance.
          Thank you for all your great information. My naturopath and me find it very useful on this complicated subject.

          Grtz. Mirjam

          • Dr Lynch September 6, 2014 at 10:10 pm #

            The term ‘always’ is not good. I should not have used that.

  7. Kim March 8, 2012 at 2:10 pm # Reply

    Dr. Ben,

    Since finding out about MTHFR this has been my most visited website about it and I learn more each time I come. I really wish our doctors took this mutation seriously and would read your website too. I did take some articles from your site to them but I could tell they are not interested.

    You mention the side effects of too much methylfolate in this article but my question is when you have disorders (fibromyalgia, migraines, and more) already that cause these issues? I understand that these symptoms might worsen but would you not get them if you already have them?

    Also, when you say to go slowly with the supplements would one week between each new one or increase of one be enough? I have started my daughter and myself on methylcobalamin at 5,000 mcg for one week and then added methyfolate at 1 mcg a day for the past 10 days ontop of the b12. I am considering increasing my daughter’s methylfolate 1 mcg to help with her major depression but am torn about maybe adding vitamin c next instead. How do you evaluation how long between adding a new supplement and deciding which one to take next based on your symptoms?

    thank you so much!!

    • Dr Ben March 9, 2012 at 6:56 pm # Reply

      Kim –

      Great questions. I appreciate your passion in trying to get better – and your child.

      It takes a physician to understand what to target first, next and so on. This article is merely a guide – and a basic one at that – on how to tackle the C677T variant.

      It does not address the A1298C variant.

      Major depression has many causes – MTHFR defect is one but there are so many others.

      In terms of depression, there is more benefit potential from increasing methylfolate than there is with vitamin C.

      I would start with increasing the methylfolate while monitoring for methylfolate side effects. They are not fun.

      If I don’t get any response from someone taking methylfolate, I increase the amount and wait at least 3 days. I then increase it again. Wait, I keep doing this until an effect is seen – either positive or negative. I then adjust the methylfolate and get that optimized before I proceed on to the next supplement.

      I am big time into lifestyle and dietary changes so there are a lot of lifestyle/dietary changes that people are doing at the same time – and many of those are in the list above in the article.

      Inositol is also very effective for depression – start low and work up once you have worked with the methylfolate and methylcobalamin.

      You must understand that the body is dynamic. If one does well on 5000 mcg of methylcobalamin and 2 mg of methylfolate for 3 months and then starts to have side effects, then it is time to adjust the amount taken. It takes practice to ‘listen’ to your body but you’ll get it – especially with the help of a good physician.

      • Kim March 16, 2012 at 6:33 pm # Reply

        Thank you for your very detailed response. As your article mentioned my daughter did well on the 1000 mcg of methylfolate for just over a week and then she started having the side effects of muscle cramps in her calves, headaches most of the day and massive fatigue. I have had her start to skip a day as of today and then we will give her niacin on the days she takes it if she get a side effect. I think B6 is the next thing for her so she make sure the whole metholation process has all three componants and then we can work up the methylfolate from there while adjusting to deal with side effects.

        I am also getting the headaches too but like I mentioned before I already have headaches, muscle pain and fatigue so it is a challange so sort out which came first. FUN FUN stuff.

        I am wondereing if you have a supplement you suggest for a child with Down syndrome and autism? Since my 7 year old can not take the B12 the way the rest of us do, dissolving it in her mouth I wondered if you think the spray Methylcobolomin is a good choice and a brand type you recommend? Also with her being heterozygous 677 and my almost 4 year old son being homozygous 677 I wondered how you decide what dose of methylfolate to start kids on? Do you adjust by body weight, mutation type or symptoms or maybe a combo of all of those? Since my daughter would not be able to tell me what side affects she is feeling I would think you would want to go slowly and maybe I would see a differnce in her JRA as it is working. I have 1000 mcg methylfolate caps so I thought I could quarter them and start like that.

        I am able to listen to my own body very well as you said but I have to have a keen eye to listen to my daughter’s body since she can’t do it for herself.

        THANK YOU for all you do here. I knew for the past 17 years (since my first daughter was born with biliary atresia) and through having my daughter with Down syndrome and all the health problems we all have that there was more to the story. Most other doctors look at one symptom at a time and like to send you to specialists for each one but like you said, the body is dynamic and works synergistically and not many doctors see that, you do. Now you just need to get on one of Oprah’s shows and spread the word!!


        • Dr Ben March 16, 2012 at 9:34 pm # Reply

          Hi Kim –

          It gets complicated quickly – especially with Down’s as they have increased CBS activity which needs to be slowed. Be careful of vitamin B6 – you likely need to avoid it with her. B6 speeds up CBS enzyme and that should not be sped up in Down’s. You likely have to supplement directly with glutathione. I am not a Trisomy 21 expert but I know that those with this have issues with CBS upregulation.

          You start methylfolate very low and work up slowly – but not after you begin B12 first – and not until you address the gut first.

          With children, I gave 1/4 tablet of Sublingual Active B12 with Methylfolate every other day and look for symptoms. I also ask kids, “Point with 1 finger and show me where it does not feel good.” If they feel bad anywhere, then you know you need to back off or change something.

          There are countless genetic variations beyond the wild type gene which our body’s express – and that we do not know we express. You know about MTHFR but you don’t know about other possible mutations – this is why I am creating a methylation profile that goes beyond methylation – also addresses detox and neurotransmitters and histamine.

          A consult is highly recommend if you get stuck. Trisomy 21 definitely complicates it a bit.

          I am working on getting the word out – I am finding I have to expand my knowledge beyond MTHFR before I do – and your daughter is one reason why. If we just addressed the MTHFR and did not understand the relations between the CBS and MTHFR genes, then a successful outcome would not be possible.

          • Kim March 17, 2012 at 12:37 am #

            You said to start with a 1/4 tablet of sublingual Ative B12 is that whole tablet the 5,000 mcg? You said start methyfolate every other day but what dose do you chose for young children to start with? I don’t want to flood them too much out of the gate but want to make sure I am giving them enough to see something one way or the other.

            Thank you for the info on Down syndrome and CBS, I had not heard of that yet. We are all such complicated beings and then add in DS and ugh. I will avoid the B6 with her.

            I have read on several websites that there is a severity order of the mthfr with homozygous 677 being the worst then 677 & 1298. Is it true there are severities other than the differences between 677 & 1298?

            I will try some things out with all my kids and then once I know how things are going and we have something to go over I schedule a consult with you. I know my kids are super complicates with Down syndrome, autism, liver transplants and unexplained other issues between them all but it seems most people on this site have a ton of issues as well so we are not special ;-)


  8. Thera Tolman March 12, 2012 at 5:54 pm # Reply

    Dr Ben,

    I am so grateful to have found this site! I just tested positive for Homozygous C677T after forcing my doctor to test me for it. I am 31 and have been dealing with infertility for 5+ years, one miscarriage; I also have endometriosis that makes it harder to conceive. I have a mild form of Spina Bifida (Occulta) so I have always taken a little more folate. I have recently switched to Thorne 1 MG of Methylfolate. I take New Chapter Organics Pre-natal, Co-Q-10, Fish oil, Evening Primrose and Cal/Mag and will start adding in the other supplements you recommend. What would you recommend instead of the baby aspirin to prevent blood clots? My doctor said if I do get pregnant that I need to go on daily heparin shots. Is there anything else you recommend? I really appreciate any response.

  9. Emily March 12, 2012 at 6:08 pm # Reply

    I have the 677 hetro mutation. I used to take New Chapter Organic vitamins for better absorption since they are whole food vitamins. My doctor has put me on MultiThera 1 by ProThera so that I can take 1 pill a day for a week and slowly increase from there since my body has never really had methylfolate. I have written the company to see if they are a nuturaly derived vitamin or synthetic. Do you have an opinion on the switch to ProThera?

    • Dr Ben March 12, 2012 at 9:37 pm # Reply

      Emily –

      Natural food folates vary in which form of folate it is. I do not recommend a whole food folate supplement in those with MTHFR defects.

      ProThera, Thorne Research, Pure Encapsulations, Vital Nutrients and many other top supplement companies use synthetic vitamins – but they are well-absorbed and utilized. I know this first-hand from my years of experience working with patients and clients.

      Of course, you want to maintain a solid intake of healthy foods which are naturally high in folates – UNcooked dark, leafy greens are excellent.

  10. Natalie March 18, 2012 at 8:47 pm # Reply

    Quick history on my daughter: She exhibited autistic stimming behaviors, had a history of candida rashes all over her body (since birth, despite prompt treatment as soon as they began to appear in her diaper area), and had no IgA, minimal IgM, and low IgG when I finally demanded immunological testing when she was 22 months old. She received her MMR at 18 months (prior to Ig testing), because I had no idea that she had immune dysfunction and had been brainwashed to think that vaccines are safe for all children. She had a bout of diarrhea lasting over a month after the MMR and the autistic-type stimming started shortly after that. I feel that the GAPS Diet has nearly cured her. (I was already an environmental toxin paranoid type and she had always been fed organically. I found GAPS after my husband and I noticed that her stimming occurred after meals, especially those containing grains.) After less than three months of the GAPS Diet, her Ig’s were all very close to normal–if they had not still been out of the normal range I would have thought that the first test was a lab error. She continues to improve, but I still see some neurological signs and symptoms (e.g., occassional loss of balance and coordination, occassional slurred speech, and occassional stuttering). She also has spider telangiectases on her face (some present at birth, and some new)and bruises easily. I was worried that she had a rare neurological disorder (i.e., A-T), but now that she has improved so much on the GAPS Diet, I am hoping that she may “simply” have a disorder of detoxification such as MTHFR. I just purchased your Kids Optimal Multivitamin. I LOVE it so far. She has no problem eating the powder. I tasted it first and it actually has a pleasant, citrus-like taste. She is a very muscular, 29 lb two-year-old, and my best guess is to give her 2-3 caps per day in divided doses, based on avoiding toxicity with the fat soluble ingredients (especially given that I am also giving her Fermented Cod Liver Oil too). Now that I have seen your posts on starting low and slow with the Metafolin, I am wondering if my guess of 2-3 caps per day for a child her size may be too much? What have you used as a starting and final dose in children her size, and what were your results? Any other suggestions for kids like her? I already have her on Bio-Kult probiotics and give her Saccharomyces Boulardii when I see the early signs of a candida rash. (I just bought a bottle of S. Boulardii from you, rather than from my previous source, because I greatly appreciate your wonderful free site! You are doing an incredible service to humanity!) What do you use in your practice for daily limits of vitamins A, D, E and K, in a child her size? How much DHA and EPA do you like to see a child her size receive in your practice?

    • Dr Ben June 3, 2012 at 9:14 pm # Reply

      Natalie –

      I apologize for missing your comment. If I do not respond as they come in, I may not get to them.

      2-3 caps per day in divided doses for your little one sounds about right.

      I would also evaluate Vitamin D3 levels, serum ferritin, TSH, T3, T4 and methylmalonic acid.

      Adding in fish oil like you are is also likely a good thought.

      Consider giving her 1 capsule of the Saccharomyces boulardii nightly along with Bio-Kult. One needs to stay on an anti-Candida protocol for some time in order to limit the reproduction of the yeast.

      For vitamin D3, consider 1,000 IU of D3 per 25 lbs of body weight.

      For the A, E and K, I am not sure what the amounts would be ideally for her age. Please check the Linus Pauling website or ask her pediatrician (who hopefully is integrative).

      The Sublingual Active B12 with Metafolin may be a welcome addition to her. Start out with 1/4 tablet upon rising and see how she does for a week.

      The amounts of EPA and DHA totally depend on the situation and what is going on. Minimum though would be a gram of EPA/DHA blend with a larger emphasis on DHA.

      Vitamin C may be useful to help reduce her telangectasia as vitamin C supports collagen formation.

      There may be some foods which are still causing issues with her –

      Due to bruising easily – do consider low iron levels. She may need some iron. If so, consider 1/2 capsule of Optimal Iron Plus Cofactors.

      Serum ferritin is the best way to check for low iron.

      Keep me posted.

  11. Megan March 28, 2012 at 5:44 pm # Reply

    Dr. Ben, I’ve posted on here before and was provided with some great information. So I’m turning to you again for advice. I have Double Mutation C6777t and A1298C, I’ve had several MC’s but also have two beautiful children. I had a tubal ligation back in 09 after my son due to all the trouble during his pregnancy. I since then have had several issues with my regular cycle after having my son. During an ablation there were complications and they tore through my uterine wall. Now months later still having issues. I’m seeing a new Dr and we are contemplation having another ablation or going in for a laproscopic Hysterectomy. After reviewing my record he didn’t feel comfortable doing the surgery with out me seeing a hematologist. I do have an appointment end of next month. Which brought me to another string of questions. I haven’t had too many issues in past surgeries but have been minor ( gall bladder removal, tubal lig) What if any potential precautions should I take prior to my surgery.

    He also mentioned that I should have never been put on Birth Control due to my MTHFR. I was put on estrogen and progesterone after trying several other BCP. It didn’t help my situation but seem to make the duration of my problem last longer. Sometimes 2-3 weeks. Is this something that my daughter will need to take into consideration as she gets older? Or rather are you aware of any links to this issue?

    Also my son has a the same double mutation and it was recommended that he doesn’t have nitrousoxide during surgery. He has a short femur and missing kidney, among other issues and deformities. His dr’s would like to correct the femur but again are in the same situation with making sure if there are any precautions they should know about we get that information to them sooner then later.

    It seems every time I go to any Dr, they either provide more information that I’ve never found any research on or they have no clue and are forced to draw out processes and appointments until they get second opinions. Its a little frustrating!

    • Dr Ben March 28, 2012 at 6:32 pm # Reply

      Megan –

      You should not use birth control with a double C677T MTHFR mutation – that is correct.
      Your daughter, if having MTHFR mutations – and she likely does – should avoid birth control pills. All women should actually –

      Nitrous oxide should be avoided in those with MTHFR as well. Nitrous oxide inhibits the methionine synthase enzyme which then increases homocysteine levels. If your son incidentally get nitrous oxide, immediately give him methylcobalamin, methylfolate and pyridoxal-5-phosphate – which all can be found in HomocysteX. You can also give him 1 sublingual tablet of Active B12 with Methylfolate if he cannot swallow pills.

      In terms of your surgery risk, the risk of blood clotting increases the longer one lays on a hospital bed – even for those without MTHFR mutations.

      I recommend you support your MTHFR properly – if you are low in methyl groups, then you have a limited ability to heal and process the anesthesia – plus you have an increased clotting risk post-op.

      The doctors need to identify which anesthesia they can use – and it is those which do not inhibit the methionine synthase pathway. I will work on identifying which anesthesia may be used – it is a great question that needs to be answered.

  12. Jv April 13, 2012 at 6:52 pm # Reply

    What do you suggest for a child with ASD who is homozygous for c677t and a1298c? Do not know where to start. Thanks

  13. Maya April 29, 2012 at 7:17 pm # Reply

    I would just like to point out that none of the multivitamins listed, or the prenatal have sources of K2 in them. Since this is commonly deficient in our diets – especially in ones with reduced intake of animal foods – this may be a good addition to your protocol.

    Also, I didn’t know that krill oil is more useful for nerves than fish oil. I’ll be making the switch!

  14. Lynn_M April 30, 2012 at 4:40 am # Reply

    Dr. Ben,

    You recommend TMG in this protocol. You may be interested in the caution that Dr. Rich Van Konykenburg (richvank) expresses about TMG at post #360 found here:, in response to someone wondering if they had symptoms from TMG:

    “TMG stimulates the BHMT (betaine homocysteine methyltransferase) reaction, as it is a reactant for it. This reaction takes place in the liver and kidneys. It is an alternative pathway for converting homocysteine into methionine, and it will help to produce SAMe in those organs.

    There are a couple of ways that it might produce symptoms. One is that it will initially lower the flow of homocysteine into the transsulfuration pathway, so the rate of production of glutathione may drop lower initially. So symptoms could be caused by initially making the glutathione depletion somewhat more severe.

    Another possible mechanism is that it can also take homocysteine away from the main methionine synthase pathway initially, and that will impact the folate metabolism, since the conversion of methylfolate to tetrahydrofolate will decrease in the liver and kidneys.

    A little TMG is often helpful when methylfolate and B12 supplementation are started, because it can help to raise SAMe, needed for recycling methyl B12. After these supplements are well underway and methionine synthase is coming up in activity, the TMG can be stopped, or DMG can be added to counter the BHMT pathway, so as to route more of the homocysteine to the methionine synthase pathway and the transsulfuration pathway.”

    And at post #393, same thread:

    “However, note that TMG stimulates the alternative BHMT pathway from homocysteine to methionine in the liver and kidneys. TMG will promote production of SAMe, but it can shunt flow away from the methionine synthase enzyme, which is partially blocked in ME/CFS. It’s important to get this enzyme going, because it is linked to the folate metabolism, which is needed to make new DNA and RNA, and also because it regulates the entire sulfur metabolism. In Amy Yasko’s protocol, she recommends starting with some TMG, and then after the B12 and folate have been built up some, to add DMG, which will inhibit the BHMT reaction by product inhibition, and that will push more of the homocysteine through the methionine synthase reaction. The benefit of doing TMG first is that it can increase the level of SAMe, and that is needed by the methionine synthase reductase reaction, which rescues the cobalamin coenzyme of methionine synthase when it becomes oxidized, thus restoring it to the +1 oxidation state and giving it a methyl group, so that it is a functional methylcobalamin molecule again.”

    Admittedly Rich’s comments are directed to people with ME/CFS, whom he hypothesizes as having a glutathione depletion-methylation cycle block. However, In his video series that you link to in your resource section, Dr. Neil Rawlins also recommends DMG over TMG for people with MTHFR mutations, as does Dr. David Brownstein. I have generally seen TMG recommended elsewhere for MTHFR mutations, perhaps because TMG has more methyls available to donate than DMG does. But looking at the full picture of the methylation and transulfuration cycles may mean DMG is the better agent to continue supplementing with after starting with TMG.

    • Dr Ben April 30, 2012 at 7:24 am # Reply

      Hi Lynn –

      I always enjoy your posts – ;)

      Rich is a brilliant man and is quite knowledgeable in the areas of methylation.

      I should note that I recommend TMG never by itself – rather in a mix such as HomocysteX Plus. I agree with Rich that if just taking TMG, one may have insufficient glutathoine production. In a formula such as HomocysteX Plus, one gets the methylcobalamin and methylfolate to support the Methionine synthase enzyme along with the riboflavin-5-phosphate to support the MTHFR enzyme and the pyridoxal-5-phosphate to support the cystathionine B synthase enzyme which is needed to produce glutathoine – so it covers all bases.

      I don’t like DMG when taking these other nutrients as it may cause overmethylation. I think a bit of nutrients needing to become methylated is supportive – unless of course there is a mutation in the BHMT enzyme – then DMG is useful. DMG is also a lot more expensive than TMG and so far I have not experienced any issues with TMG vs DMG.

      It all depends on the individual – that is why I call it a ‘basic protocol’

      Some may do better on the DMG while others on TMG and others cannot tolerate either one. I do not like using DMG out of the gate due to too much substrate leading to inhibition of the BHMT enzyme – which Rich is aware of. This can cause increased homocysteine levels if other pathways are blocked.

      This is why I typically recommend people to start out first with methylcobalamin, then introduce methylfolate, then pyridoxal-5-phosphate, then add in riboflavin-5-phosphate along with TMG. This stimulates the methylation cycles into action without absolutely firing on all cylinders.

      I also think that Rich’s and Amy’s recommendations appear quite good – there are multiple ways to approach this – and we all will refine it as we continue to learn more.

      As of now, I’m having quite good success with methylcobalamin first, then methylfolate, then active B6. As long as magnesium is on board (and I recommend this also), then SAMe can be made indirectly via these precursor nutrients. We continue to spin the cycle faster when B2 and TMG are added – allowing for additional detoxification, neurotransmitter production and gene regulation to name a few.

      Keep the comments coming ;)

      • Lynn_M April 30, 2012 at 4:06 pm # Reply

        Dr. Ben,
        Thanks for your reply. It’s obvious you’ve given a lot of thought to this issue, and I’m glad you’re familiar with Rich’s and Amy’s work. The biochemistry of all these enzymes and cycles is so complicated, it boggles my mind. Given the complexity of this subject matter, and that the treatment of MTHFR mutations is such a leading edge venture, I would expect that there will be variations in treatment protocols. I enjoy learning the thought process behind each protocol.

        When I look at diagrams of the interlocking genomics of methylation, transsulfuration, and Krebs cycles, the role of the MTHFR genes is always represented as one box labeled MTHFR. Yet I know that the C667T mutation impacts physiology differently than the A1298C mutation, so this usual representation of MTHFR’s role seems much too simplistic to me. I’d like to see a graphic of a more detailed presentation of how each of the common MTHFR mutations interact with the rest of our biochemistry, and what the similarity and differences are in their impacts.

        While I’m building my wish list, I hope you are still working on creating a basic protocol for the A1298C. Your recent presentation was helpful for understanding, but it would be really nice to have something printable that I could show to my doctor and relatives, similar to the C667T protocol you give here.

        Thanks for the positive feedback on my comments. I know you can’t address everyone’s questions and concerns, that would be a full-time task just in itself, so I try to jump in where I feel I can be helpful. I find it so irksome to read about doctors recommending bad protocols, especially folic acid, and I want everyone to become self-empowered and knowledgable enough to follow a better protocol. Once I learned I was homo A1298C, I feel like I’ve quickly climbed out of a life-long black hole of depression and lethargy, one I didn’t even know I was in, just by changing the brand and method of taking mB12 and adding in adB12. I’ve taken supplements and mB12 for years, but my improvement from the change in active B12s was striking. I’m still working on optimizing my protocol. I want everyone else to find their optimal protocol and energize their lives too.

        • Dr Ben May 2, 2012 at 4:46 am # Reply

          Hi Lynn –

          I am starting to wonder if there is really a forward and backward reaction with the MTHFR gene defects. The symptoms I am seeing in people do not seem to relate to which MTHFR mutation they have. This may be due to other mutations existing along with their dietary and lifestyle factors confounding the issue.

          However, it also doesn’t make sense that the A1298C MTHFR mutation affects the Biopterin aspect while the C677T affects the Methionine cycle.

          This would mean that the MTHFR enzyme pushes the methylfolate in two directions – yet this doesnt make sense.

          It would also mean that the MTHFR enzyme may be located in various parts of the body and the various functions of methylfolate that it produces causes different results – such as methylating homocysteine or recycling BH4. This could be possible but I haven’t researched this. I know methylfolate is used in the CNS but is the MTHFR enzyme located in the CNS? I don’t think so. Where is the Methionine cycle located? Which parts of the body? Where is the BH4 cycle located? Which part of the body? These are good questions that need to be answered and once answered, they will provide an understanding of why MTHFR produces a ‘forward’ and ‘backward’ reaction.

          However – if you think about the MTHFR mutations in another light:
          – An incorrect base at position 1298 in the MTHFR gene causes the MTHFR enzyme to be shaped one way beyond norml
          – An incorrect base at position 677 in the MTHFR gene causes the MTHFR enzyme to be shaped another way beyond normal

          How badly shaped is the MTHFR enzyme when it has the A1298C mutation?
          How badly shaped is the MTHFR enzyme when it has the C677T mutation?

          How do these shape changes then alter how the methylfolate is acting on the various cycles in the body? It doesn’t make sense that the shape of the MTHFR enzyme would alter how the methylfolate acts upon the body. The only thing that a misshapen enzyme does is limit the effectiveness of that enzyme.

          If the function of the MTHFR enzyme is to produce methylfolate, then methylfolate enters circulation. This methylfolate then can be used for the methionine synthase enzyme or recycling BH4.

          I’ve looked at Yasko’s presentations on A1298C and they do not provide evidence in my book to prove that there is indeed a backward reaction for the A1298C which affects biopterin.
          Have you seen anything to prove this point? Convinced of it?

          I think what needs to happen is to measure one’s biopterin levels along with the various forms of folate, nitric oxide, ammonia, nitrotyrosine (peroxynitrite), taurine, gluathione (red and ox), MMA and run a pretty comprehensive digestive stool analysis. This test alone could identify a lot of issues.

          I’ve read that you are doing better with adB12 and I am learning more about how this form of B12 works. I am also learning that there is a fairly common mutation that affects how methylcobalamin converts into 5-adenosylcobalamin (20% of the population has it!). I am guessing you may have that mutation. I am in the midst of identifying that mutation now. Maybe Rich knows? I don’t think it is MTR/MTRR. I read this in my Nutritional Biochemistry book but haven’t finished that chapter yet.

          UPDATE: It appears that the issue is with cbIE and cbIG; This paper could be quite good. I will read it soon.

          I do want to write a protocol for the A1298C MTHFR – I am beginning to believe that it is going to be very similar to the protocol for C677T. With that said, I think there needs to be a fundamental approach towards these mutations and we need to not get stuck on them as they are not the reasons why we are sick. We are sick because our environment is making us sick – and this is what is triggering our phenotypic and epigenetic expressions of these mutations. Once we improve our food, digestive system, mind and environment, I firmly believe our genetics will be more in tune and function better. If you look at our childhood and younger years, for the most part, many of us were healthy at one point. The younger children of this current generation; however, are not that fortunate as their mother’s womb was already a toxic place to develop and then they are born into a world of immense toxicity and GMO’s and BPA/pthalates/vaccines/fire retardants, etc

          Work in progress this all is. I think what is most important is to not forget the simple aspects of healing and maintaining health:
          – proper food and water
          – healthy environment
          – positive outlook
          – sleeping
          – community
          – exercise
          – proper digestion and assimilation

          Wow – that was a soap box.

          • Lynn_M May 3, 2012 at 9:37 pm #

            I’m still trying to assimilate the paper you linked to. Interesting to think about the cblE and cblG.

            Rich has said that, as he understands it, the conversion to methylcobalamin and adenosylcobalamin normally takes place in all the cells individually, not just in the liver. Look at Rich’s and Freddd’s posts on this page: And I believe it was one of them who also said that the transport form of cobalamin is first taken into the lysosome of the cell, where it is altered and then released into the cytosol. So when you ask where the methionine and BH4 cycles are located, I think the answer might be that it is in the cytosol of all cells.

            I have read a doctor say that A1298Cs need MTHF for the backward reaction, but he didn’t offer justification. Unfortunately the idea of forward and backward reactions seems to be too fine of a point to generate much if any discussion.

            Regarding a possible similarity of C677T and A1298C protocols. Have you known of any A1298C people having problems with clotting issues? If not, wouldn’t that difference in symptoms lead to some difference in protocols?

            You advocate P-5-P and R-5-P forms of B6 and B2 and that’s what are in homocystex. However, according some research, only non-phosphorylated vitamins can enter tissue. Bioavailability of vitamin B6 from pyridoxal 5’-phosphate requires hydrolysis of the phosphate group before absorption through the intestinal layer may occur. Once the phosphate is hydrolyzed off, the vitamin enters the cell, becomes phosphorylated again into P-5-P, and then is in the active form available to be a cofactor in the over 160 enzyme activities.

            You can find the forum discussion about this and research links here: I don’t know if there are other factors to consider as to whether P-5-P has benefit or reduced benefit when taken as a supplement, compared to pyridoxine. and I’d be interested in your take on this issue.

          • Dr Ben May 3, 2012 at 10:54 pm #

            Lynn –

            P-5-P does have to have the phosphate removed prior to entering the cell – that’s true. However, there are people who respond significantly better with P-5-P over the HCl form – I’ve seen it clinically over and over again. Hydrolysis is a reaction we can all do. This is why I use it.

            I don’t think it is so much though of a ‘forward and backward’ function of the various MTHFR defects but rather a variation in the shape of the MTHFR enzyme. My guess is the MTHFR 677 T base change has more affect on the shape compared to the 1298 C base change. Meaning, that the incorrect base at the 677 position creates more problems in the enzyme function compared to the 1298 position.

            Decreased methylation is the end result of MTHFR defects and if methylation is decreased severely, more severe issues are going to occur –

            Once I see full proof of a ‘forward and backward’ reaction to the 1298 MTHFR mutation, then I will approach it differently. As of now, I am finding success using the B12, methylfolate, treating the gut, improving the environmental surroundings and being sure not to overmethylate as that can be just as harmful as undermethylation.

            I think I am one of the few doctors that does not use much methylfolate in those with MTHFR defects. I use it – yes – but low amounts. This is likely because I restore methylation by reducing toxic load and repairing the gut/improving diet and the environment.

            Lots of studies/research needs to be done here – we’re at the forefront and discussions like this is what propel it forward.

          • Dr Ben May 3, 2012 at 11:17 pm #

            I cracked open my biochemical nutrition book: (NOTE: PLP = P5P = Pyridoxal)
            “Pyridoxine, pyridoxal and pyridoxamine are absorbed primarily in the jejunum by passive diffusion. At physiological intakes, the vitamin is absorbed rapidly in its free form…most is released unchanged into portal blood and taken up by the liver where it is converted to PLP. PLP is the main form of vitamin found in systemic blood. Most PLP is bound to albumin…..Only unphophorylated forms of the vitamin are taken up by tissues, thus PLP in the blood is hydrolyzed prior to cellular uptake….Most tissues lack sufficient oxidase to convert pyridoxine and pyridoxamine to PLP.”
            Source: page 365 of Adv Nutr and Human Metabolism, 5th Edition.

            Conversion to the active form of B6 requires B2.

            “PNP and PMP are converted by the action of an FMN-dependent oxidase to PLP. Thus, B6 metabolism is dependent upon riboflavin status.”

            I prefer to use the most active forms – even if they have to by hydrolyzed first to enter the cell – especially in the population that I work with.

          • Lynn_M May 3, 2012 at 11:46 pm #

            So P5P, once it’s been hydrolyzed, can still be distinguished from PNP and PMP?

            And PLP does not need an FMN-dependent oxidase to become phosphorylated again?

            If so, it’s understandable why some people would do better with an active form of B6 that is not dependent on riboflavin status.

        • Heather February 9, 2015 at 6:32 pm # Reply

          Hi Dr. Ben,
          I agree with Lynn, please post some basic protocols for homo 1298 mutations.:)
          My daughter is homo A1298C and manifests it with nervous system issues and delays. I feel like I’m experimenting on her with supplements. I have devoured your site, but would love a basic protocol for homo A1298C. Thanks for all the information!

    • Michael (NW) January 30, 2015 at 6:56 pm # Reply

      Hi Lynn,

      I think we’ve communnicated on here before. I could use a little advice… I’m getting better all the time. I took the SpectraCell test and have been replenishing my minerals, etc…I believe I also suffered adrenal fatigue which is getting better with the treatments I’m doing, including the mineral replenishment, taking low doses of DHEA, Liposomal Vitamin C, Magnesium, etc.. Also, both active and standard forms of Vitamin B5 have been very helpful.

      But, I still have not had one doctor be able to properly help me with my methlyation issues. And I believe this has some thing to do with why my mental health (depression) hasn’t fully resolved, including my insomnia. It has been getting better thought but VERY slowly.

      I have MTRR/A66G ++, MTRR/11 +-, BHMT/1 +-, CBS/C699T++, VDR/Taq1 ++, VDR Fok1 +-, and NOS/D298E ++.

      Previous testing showed I had a high need for B12 and Glutathione. I’ve had elevated Histamine and Homocysteine levels in the past. All this reflects my Methlyation status.

      My symptoms have been anxiety (severe outbreak the last couple of years), depression, insomnia, adrenal fatigue, etc…

      I have been replenishing my minerals as I was VERY low in Magnesium, B12, Zinc and Manganese. This has been helpful. I’m taking a co-enzyme B Complex which contains about 1000mcg of Methyl-B12. I was taking more, but I’ve read that Methly-B12 can be stimulating for those with adrenal fatigue. I also take Tryptophan daily, alter phenylalanine with tyrosine, some times both and Mucuna. Extra 50mg of P-5-P B6. I was also on 900mg of St. John’s Wort. I’ve lowered my dose to 600mg which hasn’t made any good or bad changes. I might go completely off at some point.

      My anxiety/panic is completely gone, although some nervousness outbreaks now and then. But overall this is stable.

      I still have some depression, but I think it could still be the insomnia/ mild adrenal fatigue.

      I’m trying to figure out what is best to treat my methylation status. I do believe the MTRR is an issue. I previously received B shots, but they were not co-enzyme, and now I have LARGE amounts of unmethylated B12 in my blood, 1700. But, not sure if that is because of MTRR, or BHMT, or Liver issues….So, I take Methyl-b12, well I now only take what’s in my co-ezyme b complex. I might take more Methly-B12 once my adrenals seem strong enough and aren’t stimulated by it.

      CBS, well, I had ammonia, sulfite and sulfate levels checked before doing much of anything and they were normal. No, not sure how CBS is effecting me. I do take some Taurine at times which really seems to help when I feel stimluated or have some stress. I’ve taken Methionine at times thinking my histamine levels are high, which they might be in my brain due to my methyation status, and other symptoms of high histamine like insomnia or the need for little sleep to function, etc….methionine seems to make me feel good. I also take Glutathione (was on liposomal now acetyl glutathione) which seems to help me feel better, clearer mind, mood a little better, etc…(I’m also taking Chlorella etc… to help with any detox to pull toxins out that Glutathione releases). So, not sure if CBS is causing issues or not. Might be inactive.

      VDR/Taq1/Fok1. Not sure what this is all about, other that it has something to do with Vitamin D and Dopmaine, etc…I have lower levels of Vitamin D, for some time, and it’s hard to get my levels up. They were in the 30’s. My ND wants them to be in the 80’s. I’m taking 5000iu of Vitamin D now daily.

      NOS. This one has me curious. If NOS is not functioning, then my ammonia levels could be elevated, using up BH4 causing less production of neurotransmitters like dopamine and serotonin. Is this why my recovery has been so slow and why my mood just doesn’t get to that next level of feeling great? I’m taking Liposomal Vitamin C which is supposed to help lower ammonia, along with Zeolite (For detox) which supposidely helps to remove ammonia. I’ve read that arginine and ornithine can help, but part of the NOS issue is that it can’t converit arginine to Nitric Oxide, so taking arginine might not be good. I’m curious about trying ornithine. I have a feeling that high ammonia in the brain could be causing my wired, insomnia brain stimulating feeling where I just don’t feel tired/sleepy. Although now and then I do and it’s getting better then I go through a phase where I have a hard time falling asleep or I keep waking up at 3am wide awake. I’m not anxious, doesn’t appear to be adrenaline, I’m calm, relaxed. So, I’m thinking it’s either ammonia or histamine that is causing my insomnia.

      BHMT…I’ve been reading up on TMG and DMG. I’ve read your post here along with Dr. Ben’s. I’m still confused about what is best to take. TMG or DMG. Does DMG also help to convert homocysteine to methionine? With my methlaytion status, which is best for me, TMG or DMG?

      I am getting better on the protocol I’m currently on. But, I’m not sure if I’m doing what is best for BHMT, NOS…. I’m not too worried about CBS as that doesn’t seem to be a problem but I’m not sure.

      Anyway, let me know if you have any questions or comments. Thank you!

  15. Bonnie May 2, 2012 at 3:12 am # Reply

    I am 56 and recently learned I am positive for homozygous C677T. I have a history of breast cancer (11 years ago) and recently was diagnosed with cervical dysplasia. I am scheduled for surgery using the LEEP procedure and my OB/GYN recommends that I be under a light general anesthesia. I am concerned about the anesthesia given the MTHFR. I Is there anything you could suggest that I do? I am not informed about the kind of anesthesia that will be used. Are all forms of anesthesia problematic? Is there anyway I can prevent problems? I plan to talk to my doctor about the MTHFR. Can you direct me to anything, research that would help me present these concerns to my doctor?

    • Dr Ben May 2, 2012 at 4:27 am # Reply

      Hi Bonnie –

      I recommend asking your doctor to use only a local anesthesia. You likely do not need to be under a light general anesthesia as the procedure is not that bad as long as the local area is numbed.

      Nitrous oxide is most commonly used and can be an issue for you given your C677T MTHFR status. I highly recommend showing your doctor this article.

      I also recommend showing your doctor this presentation on MTHFR – and you should watch it when you have time as well.

  16. Amanda May 3, 2012 at 1:02 am # Reply

    I am currently trying to conceive and not sure if I should be following this protocol, the pregnancy protocol you have listed elsewhere, or some combo of the two. I’m hetero c667t. I’ve been trying to conceive since my miscarriage last year. Any help would be appreciated! Thanks!

    • Dr Ben May 3, 2012 at 7:09 am # Reply

      Hi Amanda –

      There are multiple causes for miscarriage beyond the C677T MTHFR mutation – as you are most likely very well aware.

      I do prefer talking with those trying to conceive and carry to term rather than recommend some things blindly.

      Experience and science do point to these general recommendations for optimizing health and MTHFR C677T mutations. Of course, they are not guaranteed nor fully researched directly as I wish they would be.

      One has to remember that the MTHFR defect is only one piece of the puzzle and that all pieces must be evaluated – organized – and then put together properly in order to have a truly successful outcome. Medicine can truly be an art and when it is practiced well – is pretty rewarding to experience – especially when it comes to witnessing a new little one being born healthy. ;)

  17. Bonnie May 3, 2012 at 5:00 pm # Reply

    Re: Homozygous for C677T, Cervical Dysplasia and anethesia
    Dr. Ben thank you very much for your advise and references regarding anesthesia, in particular nitrous oxide, with C677T. I will sharing the references with my PCP and OB/GYN. I have watched your recent presentation and found it very helpful and informative. I will request local anesthesia for the LEEP.
    I have two additional questions. I am applying many of the general recommendations of the Basic Protocol,as well as adding supplements including silymarin. I am currently taking Active B12 with methylfolate, and will gradually progress to Homocystex. I am also taking supplements recommended by my naturopath for the dyplasia including Vit C (3000mg), Betacarotene (200,000IU) and ECG (green tea), as well as a suppository regimen ((Wise Woman products) for the cervical dysplasia. I will be continuting this until my surgery in another 4 weeks.
    I would like to know about adding additional detoxifying methods such as activated charcoal or Sonnes clay to help reduce toxic load. Should I wait until after my surgery? Would the clay or charcoal interfere with the supplements I am taking right now?
    Also, I started taking St. Johns Wort for mild depression a couple of months ago, before I knew about my MTHFR. Should I discontinue St. Johns Wort as I work on methylation balance?
    Thank you very much for your time and advise. Your website is an incredible resource!

  18. Mark May 13, 2012 at 10:02 pm # Reply

    Dr. Ben,

    I am male, white, 52 and in otherwise good health. After recently being dx’d with DVT in my left leg, I recently discovered I am positive for the homozygous C677T MTHFR mutation. In a way, this is good news because it finally explains why I have never been able to tolerate synthetic B-complex vitamin supplements for decades. My most recent homocysteine level was 7.9. On a side note, I am hypothyroid as well.

    The problem is that I still am having difficulty tolerating supplemental P5P and pantethine even in small doses, whereas I have no problem tolerating other B vitamins in their bio-active form, including L-5-MTHF @ 5mg/day.

    It seems that taking B6 (and B5) in any form, oral or injectable, is a dichotomy: on one hand it produces a transient spike in the Hashi’s-like thyroid symptoms (a tightness around my throat, lowered voice, irritability), but simultaneously gives me improved cognition, energy, speech, blood pressure stabilization, reduced palpitations, body temps, so this leads me to think I truly need it. I have always thought it’s related to low thyroid/insufficient cortisol output/low adrenal because I get a similar reaction when taking adrenal glandular, but after learning of my MTHFR mutation, I am not sure. I’m now experimenting with taking 10mg P5P EOD.

    I have also had a long-standing bout of dysbiosis/intestinal candidiasis since the early 80s and my recent organic acids tests showed slightly elevated in d-arabinitol, a fungal metabolite and marker of overgrowth of yeast (although my serum antibodies and CDSA stool analysis showed negative). Some practitioners believe that B vitamin supplements can be a source of food for pathogenic yeasts. Do you think there’s any merit to this theory?

    Any thoughts or possible theories as to my P5P and pantethine reactions? Perhaps a genetic mutation in metabolizing B5 and B6? What I also can’t figure out: naturally-occurring B5 and B6 from whole foods presents no problems. Since P5P and pantethine are the bio-active forms, why would my body react any differently?

  19. Josephine May 21, 2012 at 8:31 pm # Reply

    My partner and I have been trying to conceive for some time,resorting to ICSI due in part to the subnormal quality of his sperm. Our first cycle of IVF using ICSI was cancelled as our embryos did not develop and died.At the advise of a naturopathic fertility doctor he had the MTHFR test and the result is he was found to have the C677T mutation . I understand that these gene mutations can prohibit the production of healthy sperm. He has been advised to have 1-5 mg of folic acid + B12 .Reading the information on your website I gather that this is not going to be helpful and he needs the Methylfolate instead.
    Do you have any advise for men with fertility issues and MTHFR ? which supplement and what dosage would you recommend?

    • Dr Ben May 21, 2012 at 10:00 pm # Reply

      Josephine –

      Please follow the guidelines as outlined in this article. The amounts of methylfolate and nutrients vary from individual to individual.

      The key is to start with a low amount first and work up. This way side effects are reduced and over-supplementing does not occur.

      The critical nutrient to start with is Sublingual Active B12 with Metafolin – begin with 1/2 tablet under the tongue. Increase in the amount by 1/2 tablet every three days until the ideal amount is found (he’ll know by how he feels).

      He should also start on the Optimal Multivitamin – 2 capsules with breakfast, 2 with lunch and 2 around 3 pm with a snack.

      He’ll likely also need some:
      CoQ10: 2 capsules daily with any meal
      Krill Oil: 2 capsules daily with any meal
      Probiotics: 1 capsule after dinner
      Zinc: 1 capsule daily with dinner
      Carnitine: 1 capsule daily between meals – before breakfast is best.

      Eating every 2 hrs with some form of protein and vegetables is also supportive. He should eat about 0.8 grams of protein per 2.2 pounds of body weight.

  20. Liz May 30, 2012 at 3:32 pm # Reply

    Dr. Ben,
    What are the best protocols for +C677T with + A1298C. I have both. My doctor has me taking 3 FolaPro/day and 1 Methocobalamin sublingual per day. I did slowly work up to this level over 6 months. I also take VSL ( for my gut), 3 fish oil, 100mg COQ10, 3,000mg Vit C, 2,00 D3, Calcium 800mg, magnesium apx 500mg. I eat wheat free, close to dairy free, low sugar diet. Low fat protien , lots of veges/fruit.
    I do feel achy on occasion and don’t know if this is related. Is there a better protocol for me to follow? You input is appreciated.
    Thank you

  21. ConcernedMomma June 1, 2012 at 12:35 am # Reply

    I have been “googling” information for the last month since I found out my 2.5 yr old dtr also has this trait (heterzygous for the c667T gene mutation) and I have been very upset re no information at all until I found this! I plan to print this and review it with my daughter’s developmental MD to see what reccomendations I can begin with her! Again thank you for being so comprehensive and putting this information out for parent’s in need of information!!

  22. Erica June 1, 2012 at 12:47 am # Reply

    Well Dr. Ben I have recently began Deplin 7.5mg for my 2yo who was “diagnosed” with Mild PDD. I have seen a great improvement in terms of her personality (less outburts), her speech has always been delay but she has been more verbal in trying to speak.

    But as any parent I am worried all day long that she is getting what she needs. I would love to reach out to a MD that is knowledgable and can review my daughter’s “file”. Would you know of a colleague in NYC/NY I could reach out to.

    I have been so scared if I am giving my daughter the “right” care.

  23. Kris June 3, 2012 at 7:30 am # Reply

    Dr. Ben-

    Thank you for this incredible website! I see a functional medicine internist and she tested me for MTHFR a year ago. I have the C677T homozygous mutation, but not the A. I will not go into all of my difficulties here. I also just recently discovered that I have Alpha-1 Trypsin Deficiency and I am waiting on the phenotyping. I also had a TIA last October at the age of 41. I do not drink, have never smoked, watch my diet like a hawk due to an insane amount of food sensitivities, etc. I have suffered with severe depression since childhood, went through numerous psych med trials over 8 years ago, which led to toxic metabolic encephalopathy. I found a functional/holistic neurologist who discovered that I was not metabolizing or detoxifying the meds and she got me off everything. Unfortunately, the damage was done and I have yet to recover.

    I read your C677T protocol, and unfortunately I cannot do any of that. The side effects that you listed I experienced (my head was going to explode and I know what a severe migraine is and I became suicidal and my anxiety was off the chart) after a miniscule amount of methylfolate and just one dose. My doctor actually gave me three different brands to try. I do not detoxify anything and severe reactions to meds, anesthesia, supplements, etc. I have been to numerous practitioners who think outside the box. My system is so sensitive that I often just hold a supplement in my energy field to “download” it. The only supplements that I can tolerate without severe consequences are magnesium and B-6.

    My question to you is that I know that I have a severe allergy to silicone dioxide and I cannot find a form of methylfolate without it? Do you know of any? I checked your website and your version also contains it. I even contacted all of my local compounding pharmacies and they all said that it was too expensive to obtain in its pure form.

    Also, are you aware of any other genetic mutations that contribute to an inability to metabolize everything. :-) I live near a research hospital with an adult genetics department, but my insurance will not cover it.

    Thank you very much for your time.

    • Dr Ben June 3, 2012 at 9:28 pm # Reply

      Hi Kris –

      Allergy to silicon dioxide? That is basically sand. Due to this, I highly suspect your digestive system needs some intensive support.

      Have you been tested for H pylori? SIBO? Leaky gut? Yeast?

      Consider ‘resetting’ your system though a diet focusing on healing your intestines, them moving to your liver.

      You likely have other mutations on board – beyond MTHFR – such as COMT and CBS. One cannot address MTHFR mutations until the CBS mutation is addressed.

      You may do well with obtaining methylfolate from your diet: raspberries, beans and leafy greens.

      Keep me posted.

      • Kris June 4, 2012 at 6:04 am # Reply

        Dr. Ben-

        Thanks for the reply. I have spent the last twenty years going through diets, etc. and spending thousands of dollars following treatment suggestions. I went through the whole candida treatment process starting at 18. I was diagnosed with hpylori in my early twenties and went through three rounds of the regimen. I finally went through a biopsy and it and celic sprue were ruled out, as once you have a positive blood test it is always positive. I tested negative a year ago for yeast/candida and celiac and I do not have leaky gut. I cannot tolerate any high fiber foods, especially greens or beans anymore. I am highly allergic to rice and soy and I eliminated dairy years back. I have never been able to tolerate fruit in any form since childhood, nor do I metabolize fat soluble vitamins. I get jaundice within a few days. I have a low D-3 level and high homocysteine, as well as Hashimoto’s.

        If I am not allergic to silicone dioxide then I am not able to metabolize it. I know it is an issue through an elimination process. I have also been through numerous regimens to assist my digestive system if that is the issue without success. I have severe reactions to the supplements, especially probiotics. Again, I have spent thousands on traditional and alternative treatments and practitioners. My intuition tells me that something else is the source, primarily my nervous system, and as I am gaining more information on my genetic mutations possibly those. That is why I inquired about other possible genetic issues.

        I have had numerous issues since birth, but ever since I went through numerous drug trials around 2002 I have been progressively going down hill. The meds altered my nervous system and I believe I could not detoxify them. I had a phase delay sleep disorder surface at the same time. These cannot be coincidences. The reactions that medications cause also occur with herbs and supplements – even pharmaceutical grade. I have paradoxical reactions. For example, my acupuncturist had me take an herb, and it actually made the symptoms worse that it was supposed to help.

        Thank you for your time. I will continue my search for answers that do not involve more supplements that add to the toxicity in my body. I wish that energy work could successfully assist with my issues as it is the one thing that I tolerate.


        • Scott December 19, 2012 at 10:12 am # Reply

          Gee Kris your story is so much like my health story. I wish you had written the solution to your health turn around (maybe MTHR hopefully is part of the key) at the end of your post.

          • Kris December 20, 2012 at 6:54 am #

            Hi Scott-

            Unfortunately I have not had a turn around with my health. I keep getting progressively worse and have not found anyone to assist, so I am on this journey alone. :-) I cannot eat, sleep, or be out in the world due to severe reactions. The MTHFR is a component, but treatment makes me severely worse as I am sensitive to carriers and additives in meds and supplements of all forms.

            I live near one of the top immunological hospitals in the country and they have told me that there is nothing that can be done. Since, I have also discovered that I have another genetic disorder – Alpha-1 Antitrypsin Deficiency – that affects my liver and lungs. So, I have another piece of the puzzle, but no one knows how everything interacts. I have met with geneticists and all of this is too new. So, I wish that I could offer you optimism or options to try, but I do not have anything to offer. :-) The “experts” tell me that there is nothing they can offer until more is known.


    • Karen July 31, 2014 at 7:33 pm # Reply


      It sound like you have some symptoms of pyroluria, where your body excretes too much B6 and zinc… You might want to look into that.


  24. Jen June 6, 2012 at 6:21 pm # Reply

    Hi, I am homozygeous C677t, I had 2 miscarriages before this was discovered. When I was pregnant with my daughter I was on baby aspirin, lovenox, neevo and extra folic acid and b vitamins. I continue to take the vitamins and aspirin now because I am nursing and do want another child in the near future. I wanted to see what supplements are good for me while I am nursing and then again as we try for our second baby. My homocysteine levels are normal.thanks!!

    • Dr Ben June 6, 2012 at 6:23 pm # Reply

      Hi Jen –

      Please read this article on Prenatal Supplementation with MTHFR.

      Please use methylfolate and folinic acid while pregnant – it is superior to high amounts of folic acid.

      • Jen June 7, 2012 at 8:20 pm # Reply

        Thanks for your reply. I listened to your pod cast and ordered some of the supplements you suggested. I was wondering what about being homozygeous makes these miscarriages happen? The specialist I went to could not really explain it. Thanks so much. I’m glad I found your site.

  25. Patricia Ann June 20, 2012 at 12:43 am # Reply

    Hi, I just found your phenominal site.
    Two questions:
    What is the reason for eliminating wheat and gluten?
    What is the reason for eliminating dairy except goat’s milk?

    I am interested in these questions as they pertain to a positive for one copy of the C677T mutation…heterozygotes for the C677T in the MTHFR gene.
    Thank you for your info.

    • Dr Ben June 20, 2012 at 6:11 am # Reply

      Patricia –

      The whole point behind supporting those with MTHFR mutations is to limit the damage done within the body. The less damage that is done, the less methylation is required. Since MTHFR is central to methylation – literally – than we have to maximize optimizing health through reducing damage.

      Gluten and wheat are very damaging to the intestines – poking holes into our intestines from producing high levels of zonulins which break the tight junctions. This leads to inflammation, leaky gut and then autoimmune disease – not to mention lack of nutrient absorption.

      Dairy – especially A1 or most cow milk – is damaging because of the casein – and it is a very common allergen – like the wheat.

      If you read books like, ‘Dangerous Grains’ or ‘Paleo Solution’, you will learn about A2 milk or raw milk and also the harmful effects of gluten.

      In my opinion, everyone should be off of wheat and gluten in this country – due to the GMO. 15 yrs ago – I don’t think it was that bad – I used to eat wheat and gluten just fine and then when the early 2000’s came – I, and millions of other people, began reacting.

      • Patricia Ann June 20, 2012 at 3:37 pm # Reply

        Thank you, Dr. Ben, I’ll go read those books.
        Would it matter if you used non GMO wheat or is it the gluten that is a problem for MTHFR?
        Thanks again.

        • Lynn_M June 20, 2012 at 4:42 pm # Reply

          GMO wheat has been grown in research labs but it is not yet sold commercially. So GMO wheat is not the problem; the public has not eaten it. GMO means a protein of foreign origin has been incorporated into the substance through laboratory manipulation.

          Our modern wheat has been modified, just not via GMO methods. The common modern wheat variety was engineered by Norman Borlaug and known as Dwarf Wheat, or as Dr. Davis, the author of Wheat Belly, calls it, “Mutant Dwarf Wheat”.

          From “Throughout history people bred the new wheat to be more pliable, in other words to have a higher content of that retched glue [gluten]. The development of the “mutants” started in earnest in the last 50 years, primarily by the aforementioned Norman Borlaug who worked on his rouge experiments in Mexico. First they developed the wheat with a heavier seed head. Then they realized that the traditional four foot stalk buckled under the weight of the heavy head, so they developed this Mutant Dwarf Wheat variety. The Dwarf Wheat can’t grow without a fertilizer, yes allegedly it fed billions but it also starved many, even this year in India. Not to mention the central Dr. William Davis accusation of the being responsible for the epidemic of diabetes, heart diseases and the countless western ailments. This mutant wheat now accounts for 99% (no pun intended) of the wheat grown worldwide.”

          Some of the ways that scientists develop new plant breeds is to radiate seeds, or expose them to very toxic chemicals, or extreme temperatures, and then grow what will still life. Not natural hybridization methods, but not GMO.

          Modern dwarf wheat has much higher gluten content, and gluten can cause major damage. The wheat germ agglutinin, a lectin, also causes problems. Dr. Davis’ book gives lots more information about why wheat is so harmful. His blog on the subject is

          • Dr Ben June 20, 2012 at 4:55 pm #

            Lynn –

            Thank you for the correction. I used the term GMO inappropriately.

            I am glad you offered this comment – it is a critical one. I will definitely read his book. I knew modern day wheat contains much more gluten than the natural, original varieties – but I didn’t know anything beyond that.

            Look forward to learning!

          • Patricia Ann June 20, 2012 at 6:16 pm #

            Dear Lynn_M,
            Thanks for your excellent info and for mentioning the book.
            Blessings to you.

          • Dr Ben June 20, 2012 at 6:32 pm #

            Patricia –

            Yes – definitely read that book – may explain quite well for you why gluten is so bad.

            I’ve ordered the book as well ;)

        • Dr Ben June 20, 2012 at 6:34 pm # Reply

          Patricia –

          It is the gluten that is the problem –

          So becoming gluten-free is ideal – you’ll feel better – and make it a family lifestyle/dietary change so you’ll all feel better.

          • Patricia Ann June 20, 2012 at 7:08 pm #

            Dr Ben,
            You’ve been so kind to reply to my questions. Thank you.

            I’ve searched your site for a dietary/ meal plan info for those with MTHFR C677T. Unless I’m missing it, I haven’t found one.
            If you were to recommend a plan or a book or recipe book to follow, which one or ones do you recommend.

            Thanks again and blessings to you.

      • Patricia Ann June 20, 2012 at 6:14 pm # Reply

        Hi Dr Ben,
        I use clarified butter in my cooking because it has a higher smoke point and my foods don’t burn. It also has the milk removed and I believe the casein removed. Is it ok to use clarified if you have MTHFR or do you recommend another oil for cooking.
        Thanks again.

        • Dr Ben June 20, 2012 at 6:34 pm # Reply

          Patricia –

          Clarified butter – ghee – makes sense that it would be fine as it is basically just fat remaining. Fat is not the cause of allergies or neurotransmitter imbalances so ghee should be fine.

          You know how to make your own to save money? If not – learn how – it is easy. Must be a YouTube video somewhere.

  26. coreen June 30, 2012 at 12:56 am # Reply

    I just came across your website today. Last year while having my annual physical my primary Dr decided to test my DNA since my Dad and his sister both have painful neuropathy mostly in their feet and both are non diabetic. My Dad also recall his father getting B-12 shot in his later years. The blood test showed I have Homozygous MTHFR mutation C677T: Two copies . About 10 years ago I had surface thrombosis following flying back from Japan. My Dr placed me on 1 tablet of metanx and 1 baby aspirin per day. Is this a good treatment plan? Also for 10+ years I have had issues with sinus infections. I had sinus surgery in 2003 and will again on Mon in 3 days for revision surgery. I saw the concerns for anesthesia and will print out the pubmed article that you noted. Today my primary Dr and I discussed food allergies testing for IgG and IgE. It will be interesting to see if gluten shows up. I have had skin allergy testing and autoimmune defiency testing prior with nothing showing up. Have you seen a connection with C677T and sinus issues? Thanks for reading and hoping for your reply to my questions.

  27. evy June 30, 2012 at 2:47 pm # Reply

    Epsom Salt foot soak question….since sulfur issues are (or maybe just can be?) for MTHFR folks, might that explain why my daughter (who is recently diagnosed as compound hetero) gets swollen feet, swollen joints, swollen lower legs and feels lousy after doing an epsom salt foot bath? Rats! It’s supposed to HELP with toxicity…laugh! :)

    I haven’t been tested yet for MTHFR (or tests are in the mail for the rest of the family) but I’ve never been able to tolerate epsom salt foot baths either. That which is supposed to be a positive thing for my body, always did the same thing to me as it does for her.

    I also read an interesting article this morning on chlorine and methylation (my daughter can’t swim in chlorinated pools-makes her feel HORRID!).

    Sooooo many pieces to the puzzle :)

    By the way, this is an amazing site with so much helpful information!!!

    Thanks, Dr. Ben!



    • Lynn_M June 30, 2012 at 9:27 pm # Reply

      People with CBS mutations have an intolerance of sulfur. I would suspect some mutation other than MTHFR, such as CBS, is causing the problems you and your daugher have with epsom salt baths.

      Regarding your daughter’s intolerance of chlorinated pools. Because it’s a halogen, chlorine depletes the body of iodine. Perhaps your daugher is quite low in iodine/iodide.

      I think it’s always a danger than once we know of one diagnosis, that we want to blame all other symptoms on that one diagnosis.

      • evy June 30, 2012 at 10:02 pm # Reply

        Thanks for the reply, Lynn!

        We never did go to the doc to get a chronic fatigue/fibro diagnosis for I figured that would get us absolutely nowhere, so I am with you on the not blaming everything on one diagnosis :)

        The MTHFR diagnosis (compound hetero) is new to my daughter, and we are glad to at least have a springboard now, instead of continual dead ends.

        We’ve done thyroid testing which all came back fine. Maybe it’s worth further testing. Who knows….one could spend every last penny and every last ounce of energy trying to figure it all out, huh!



        • Lynn_M July 1, 2012 at 10:38 pm # Reply

          Unless someone shares their actual test results and reference ranges, I’m always suspicious when someone says their thyroid testing came back fine. First of all, the TSH test, the supposed gold standard, is totally useless for anyone taking thyroid supplementation. It’s usually so misinterpreted that it’s only good for diagnosing hypothyroidism when the condition is so bad that the TSH exceeds reference range.

          Free T3 is the only measure of active unbound thyroid hormone, and even then it only measures when is in the serum and not what iis available to the cell, which is what really counts. The only tests that measure what is happening at the cellular level, albeit indirectly, are basal temperatures and an achilles reflex test. Free T3 is the best blood test of thyroid function, but most doctors only do TSH and T4.

          Free T4 measures the inactive precursor thyroid hormone. Many people do not convert the inactive T4 to the active T3 very well, so knowing T4 isn’t that informative.

          Most doctors think if the (Free) T3 and (Free) T4 are anywhere in range, that the patient is okay. Whereas to be optimal, those values should be at least in the upper third of reference range and possibly higher.

          Most doctors don’t test for thyroid antibodies, and if they are present, they can totally invalidate any of the other thyroid test results. Reverse T3 is hardly ever done, but it can show if the body makes the inactive form of T3 rather than the active form.

          Sometimes not spending enough on testing is cheap economy. I think doctors that order only the TSH test as a measure of thyroid function are practicing a cheap economy, and in the long run, because conditions are not properly diagnosed, the savings on testing are vastly outpaced by what it costs to deal with the repurcussions of undiagnosed thyroid conditions. If symptoms indicate there might be a thyroid condition, then more indepth testing is certainly warranted.

          Regarding taking methylfolate with food. I think I’ve read it’s okay. But methylcobalamin should be taken on an empty stomach.

  28. evy June 30, 2012 at 10:44 pm # Reply

    Is there reliable info our there on whether it matters to take Methylfolate with or without food (empty stomach)?



    • Dr Ben July 2, 2012 at 5:22 am # Reply

      Evy –

      Methylfolate is best taken on an empty stomach. I need to find the source for this but that is what I’ve read for best absorption.

      • Lynn_M July 3, 2012 at 2:18 am # Reply

        The prescribing information for Deplin L- methylfolate says the usual adult dose is 7.5 to 15 mg given daily with or without food or as directed under medical supervision.

        The information for L-Methylfolate PNV DHA Oral at says: “This medication is best taken on an empty stomach 1 hour before or 2 hours after meals. Take with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. If stomach upset occurs, you may take this medication with food. Avoid taking antacids, dairy products, tea, or coffee within 2 hours before or after this medication because they will decrease its effectiveness.”

        Under the Interactions tab, it says: “This product can decrease the absorption of other drugs such as bisphosphonates (e.g., alendronate), levodopa, penicillamine, quinolone antibiotics (e.g., ciprofloxacin, levofloxacin), thyroid medications (e.g., levothyroxine), and tetracycline antibiotics (e.g., doxycycline, minocycline). Therefore, separate your doses of these medications as far as possible from your doses of this product.”

        I don’t know it decreased the absorption of thyroid medications. Guess I’ll have to change the time I take my methylfolate.

        • Dr Ben July 3, 2012 at 6:27 am # Reply

          Thanks, Lynn! Appreciate the help – I remember reading it but then I forget to cite the reference – great to have.

          I will have to write an article about how to take methylfolate – be a good idea…

      • Josephine July 3, 2012 at 8:44 am # Reply

        I am confused as the Active B12 with Methylfolate says on the bottle to ‘take with food”

        • Dr Ben July 3, 2012 at 10:45 pm # Reply

          Josephine –

          I will take a look – that is not right.

          Thank you for letting me know.

          It should be away from food, other nutrients and medications.

      • evy July 4, 2012 at 1:49 pm # Reply

        Many thanks for the time you take to reply to all the inquisitive folks here on your website :)

        In trying to determine under what conditions to take methylfolate, I had sent an email to Pure Encapsulation (one brand of 5 MTHF) and this is the reply I got in response to whether or not methylfolate is to be taken with food:


        Dear Evy,

        5-MTHF (5-methyltetrahydrofolate) should be taken with a meal.


        Juniper Devecis, MS RD CCN
        R & D/Tech Support

        Pure Encapsulations, Inc.
        490 Boston Post Road
        Sudbury, MA 01776
        Fax: 978-443-9664

        • Dr Ben July 5, 2012 at 2:15 am # Reply

          Evy –

          I believe that is incorrect – I will find research – but Lynn also found that it should be taken away from food.

          I do not agree with Pure Encapsulations at this point –

          I recommend asking them to cite references for proof.

          • evy July 9, 2012 at 4:05 am #

            I will ask them for references for proof and let you know what they say :) And will have my daughter take it away from food.


  29. Bonnie July 5, 2012 at 2:58 am # Reply

    I am homozygous 677T and I will be having 6 mercury amalgams removed at a health focused dental office with safety equipment and IV therapy. They will be using the diazapam family of drugs for the procedure (Valium and Halcion/Triazolam) and novacaine. Are these okay for me to take with homozygous 677T?

    Also they are recommending a protocol for support for mercury detox, a month in advance of the mercury removal, and afterwards, which includes the following:
    Thorne Basic Detox Nutrients
    Probiotics Klaire Labs Therbiotic Complete or Bio-Kult,
    Glutathione Support with Readisorb Liposomal Glutathione or Thorne Cysteplus
    and Metagenic Metalloclear.
    A few days before the procedure there is a recommendation for Pectasol Chelation Complex.
    I am seeking your advise on which of the above recommendations should I add to my regimen given that I am currently following your recommendations for 677T mutations and taking Optimal MultiVitamin, Homocytex Plus, Vitamin E, Liver Nutrients, Krill Oil, and Probiotic 12 Powder.
    And also CurcumaSorb, EGC-Green Tea Extract and MRS-Mushroom Formula and d-Limonene on recommendation of my naturopath for other reasons.
    Given my current regimen, what additional support will I need to add for the mercury removal as I feel there is overlap with the 677T Basic Protocol I am using. Should I just add the Readisorb LiposomalGlutathione Metagenic Metalloclear, and the Pectasol Chelation Complex in preparation for the mercury removal?
    Thank you very much for your help and advise.

    • Dr Ben July 6, 2012 at 1:06 am # Reply

      Bonnie –

      The Pectasol is a great idea.

      I also recommend you consider the Optimal Liposomal Glutathione by Seeking Health and taking the amount recommended by your doctor.

      Making sure you are taking some vitamin C throughout the day is also a good consideration. Consider taking 1 to 2 scoops of Optimal Vitamin C Powder in a liter of water and drinking it throughout the day. Or you may find you want some stronger vitamin C such as Optimal Liposomal Vitamin C – and consider taking 1 tsp three to five times daily during amalgam removal.

      I recommend asking a pharmacist to see if those medications affect the Methionine Cycle – or specifically homocysteine levels?

      I would like to research them myself but my time is so limited right now.

      You may also find that taking Chia Seed Meal is a good way to help bind metals in your gut. Consider grinding some fresh Chia Seeds daily and mixing it in some water or on your salads.

    • Lynn_M July 6, 2012 at 4:50 am # Reply

      For 24 hrs. prior to your dental work, avoid vitamin C. It keeps dental anesthetic from working.

      Too bad they won’t be using IV conscious sedation. Dr. Hal Huggins strongly prefers it. My local oral surgeon uses it. With IV conscious sedation, it’s not necessary to use vasoconstrictors such as are used with novocaine. But if you’re only have amalgams replaced, and the gums aren’t impacted, that probably won’t be as critical.

      • Bonnie July 7, 2012 at 6:51 pm # Reply

        Thanks for the advice and suggestions! Very much appreciated.

  30. Sue July 8, 2012 at 10:49 pm # Reply

    Hi Dr. Lynch,

    First of all, thanks for your great website. I recently tested positive and homozygous for C677T (no copies of A1298C). I also found I had elevated TSH which is abnormal for me.

    In my mid 20s, I suffered from anxiety and depression (family history of mental illness, autoimmune disorder, miscarriage, IBS). I combatted it with a 5 day/ week exercise schedule and Lexapro. I found after a couple years, I was able to go off the Lexapro with great results and few side effects. I maintained my health with the exercise and by following a mostly Paleo diet. Felt fine and great except for a bout with bad IBS in late 2010.

    A year ago, I moved to a different state to live with my now fiancé, I stopped exercising and eating properly, indulging in many wine/ pizza nights. It was fun at first until found my emotional issues return with a vengeance about six months ago. These were concurrent to horrible sleep issues and lethargy. So I started seeing a new doctor seeking Lexapro again and she immediately tested my for MTHFR. She gave me Lexapro in the interim while we awaited my labs, saying that I could eventually wean off the Lexapro (generic bc my insurance covered and against my Dr’s preference). She posited that I wouldn’t need it once I was taking proper supplementation.

    Anyway, after finding the two copies of the C677T mutation, my doctor put me on 15 mg of Deplin (with the choice of taking OTC supplements if I wanted), 2000 mg of NAC twice day for several months (though I am working up to this as my stomach didn’t tolerate it well), 500 mg of Glutamine, and D3 once a week. She also wants me to do B12 lozenges which I haven’t added yet. I also take a daily dose of Carlson’s Super Omega Cod Liver Oil.

    I have been doing this since the end of May. Felt immediately better and decided to start weaning off the Lexapro about a month ago. I also decided to wean myself of my birth control pills by slowing cutting off a bit of the pill (1/4 for 2 months, 1/2 for 2 months, 3/4 for two months) for the next six months in an effort to clean my body up completely. (Saw that OC can interfere with folate levels.) I want to conceive in a year or two but based on past experience, felt it was best to slowly reduce the artificial hormones in my body. I have been on the pill for years and years and when I’ve tried to stop cold turkey in the past, it’s been an acne nightmare. Lastly, I have begun to resume my exercise and Paleo lifestyle.

    Perhaps it was a bit too much for my body to do all at once. I had some extreme anxiety flare ups. They seem to have lessened as I have gone completely off the Lexapro. It’s been about a week or two.

    Anyway, here are my questions regarding the best protocol. Do you think the Deplin is too much/ not the best choice and what methylfolate product from your website would you recommend instead? Also, do you recommend Krill Oil over Cod Liver Oil? I have heard conflicting reports. By the way, I will go over all this with my doctor. I have made her aware of your site as well and she is a fan. Overall wellness and eventually carrying a baby to term are my goals.

    Best regards,


  31. Raoul July 9, 2012 at 11:08 am # Reply

    Dear Dr.Ben,

    I wirte to you from India begging for some Advice, I am a male aged 45 and have been diagnosed with the MTHFR C677T double mutation with a blood homocystiene level of 104.5, It all started with me having episodes of loss of sight in my right eye along with severe dizziness and disorientation, I have done virtually every Neurological test and MRI possible during which the visually evoked potential (goggles) showed a huge abnormailty in the right eye, and now the MTHFR test has come back positive for the double mutation of C677T. I am currently taking 5mg of folic acid and Neurobion everyday, please help with some advice as I get very conflicting advice from different doctors here.

    • Dr Ben July 12, 2012 at 12:10 am # Reply

      Raoul –

      That is a very high homocysteine.

      I highly recommend getting on some nutrients to reduce that – such as HomocysteX Plus – and you may need to take 2 – 3 capsules before breakfast and 2-3 before lunch.

      Also limiting the amount of protein you eat is also important.

      Do talk with your doctors about getting on some type of anti-coagulant or anti-blood clotting medication like Plavix, Coumadin or even a baby aspirin. You may be experiencing blood clots which must be addressed immediately.

      Folic acid is not very effective at lowering such high levels of homocysteine – especially when homozygous C677T

  32. Jen July 11, 2012 at 5:16 pm # Reply

    HI I started taking the optimal multi vitamin and active b12 sublingual, and I am homozygeous for the C677T. I have been feeling nauseous for the past few weeks and wondered if it could be from the vitamins? I always take them with food. thanks for your help. Jen

    • Dr Ben July 12, 2012 at 12:06 am # Reply

      Jen –

      Your digestive abilities may be limited and/or you may have digestive lining problems which are causing absorption issues.

      Those with any type of inflammatory bowel disorder may have difficulty absorbing a highly potent formulation.

      Consider reducing the amount you are taking of the Optimal Multivitamin – just take 1 capsule with breakfast and 1 capsule with lunch – and see how you feel.

      In terms of the Active B12 5000, stop that for now and see how the Optimal Multivitamin is working for you on its own.

      In order to determine what is causing the nausea, it is best to try one thing at a time – and in lower amounts – to prevent side effects.

      Do also take a small amount of Active B12 5000 vs taking the entire tablet. I recommend starting out at 1/4 a tablet upon rising in the AM – away from food.

      Keep me posted.

  33. Jennifer July 21, 2012 at 12:38 am # Reply

    Hi Dr. Ben,

    I am wondering if you have any other recommendations for a prenatal vitamin? The Thorne Basic Prenatal that you mentioned above has a lot of iron, and I happen to be sensitive to iron supplements. In the past, I always asked my ob for prenatals with low or no iron.

    • Dr Ben July 25, 2012 at 7:22 am # Reply

      Hi Jennifer –

      I hear you. My wife had a very hard time with prenatals and iron supplements in general – which is why I made an iron supplement on my own which is designed for those who are very sensitive to iron supplements. I am happy to say she is tolerating them very well and her iron levels are finally climbing back up to normal.

      In terms of a prenatal that is lower in iron, I cannot say I know of one that I really like.

      I do recommend these prenatals often:
      – Thorne Basic Prenatal
      – Designs for Health Prenatal
      – Xymogen Prenatal
      – Perfect Prenatal by New Chapter (but not happy about the soy in it)

      I am working on making my own prenatal but it won’t be out for a couple months. I am working on making it stand way out above the crowd. ;)

      • Jennifer July 30, 2012 at 2:38 pm # Reply

        Hi Dr. Ben,
        Thanks for your reply. I looked into the Designs for Health Prenatal, and asked them for additional information about whether their methylfolate is the L form or the D form, after reading your post about the different types of methylfolate. I was also uncertain after reading somewhere on your site that naturefolate was not a good form…

        This was their reply:

        “I asked our product development manager to help answer your question.

        His replied with the following information: “NatureFolate is a blend of the natural S-form of both 5-Methyl and 5-Formyl tetrahydofolate. The amounts of each is proprietary information. ”

        What do you think?

        Thanks so much,

  34. Val July 26, 2012 at 9:21 pm # Reply

    Dr. Ben,

    I was diagnosed with MTHFR (heterozygous C677C) during my pregnancy, 3 years ago (I was 32 then). My perinatologist put me on Heparin and Neevo DHA. I also developed gestational diabetes but it was well controlled with diet alone. At week 38 I had a placental abruption and an emergency C section. Happily my baby girl was born in very good health.
    About 6 weeks after delivery I started having severe abdominal pain and 1 year later was diagnosed with gallstones. I had my gallbladder removed.

    I didn’t really pay too much attention to the MTHFR diagnosis after the delivery because I didn’t know it could affect your health in so many ways, and because there was not much information on it, anyway.

    Recently I have been dealing with what I think are hypothyroidism symptoms: fatigue, poor concentration and memory, inability to lose weight, hair loss, severe dry skin. However, my TSH results are always “normal”. I started researching online and came to the conclusion that my symptoms might be related to Iodine deficiency. I started iodine supplementation (Iodoral, currently taking 25mg/day). I still do not feel better at all. I have even gained more weight and have what they call “bromine detox” symptoms.

    Somehow during my thyroid / iodine research I stumbled on your website and started wondering if my hypothyroid symptoms could be related to the MTHFR (I’m now guessing my past problems – placental abruption, gestational diabetes, gallstones – were).

    I want to start the MTHFR protocol but have some questions:

    •Could problems with methylation be the reason that the Iodine supplement is not working for me? Should I stop the iodine before starting the MTHFR protocol?
    •I want to clean my gut before starting the protocol. What is the best way to do it?

    Thanks for all your help!

    • Val July 27, 2012 at 6:48 pm # Reply

      I meant C677T, not C677C

      • Carly July 31, 2012 at 5:36 am # Reply

        Hi Dr Ben

        I’ve recently found out that I have Heterozygous C677T gene mutation and wanting to know where to start.

        I’ve just recently found out I have H Pylori and finished the Triple Antibiotic therapy so I seem to be quite sensitive to foods as well as supplements.

        Could you please tell me the best way to start off this protocol? I don’t have the money to buy every supplement but what would be the most beneficial?

        I also have sulfur sensitivities so tried the Methionine and had severe reactions to it.


    • Nicole February 1, 2013 at 10:15 pm # Reply

      Dear Val,

      With so many health problems it sounds like you have an Autoimmune Disease! Have you been tested for anti-bodies? I also have an Autoimmune Disease called Hashimoto, which causes the thyroid to act up. But there is many different Autoimmune Diseases.
      I am also diagnosed with the MTHFR Gene Mutation of A1298c and have researched a lot. Many people with these kind of gene mutations also have an autoimmune disease.
      Specialist doctors only treat the symptoms and not the Autoimmune Illness directly, so did my Endocrinologist for 10 years. But if you do not address this other illnesses will come. Please research!

  35. Matt August 5, 2012 at 5:20 am # Reply

    Hi Dr. Ben,

    I just ordered roughly everything that you recommended on your c677t protocol and am excited to get going on it.

    Thirteen years ago, I came down with symptoms immediately following a traumatic event and was subsequently diagnosed with chronic fatigue syndrome / fibromyalgia. After seeing over 50 doctors and no relief to my symptoms, I gave in and started taking adderall. I’ve also dealt with a myriad of other symptoms including insomnia, mental fog, and severe depression, to name a few. My psychiatrist had me tested for MTHFR and put me on Cerefolin. Anyway, the MTHFR test sent me researching and I found you.

    I have a couple of questions about your protocol:

    1. You have, “Limit ingestion of folic acids,” as part of the protocol. Do you mean not to eat spinach, asparagus, broccoli, etc?

    2. I have recently quit adderall and can barely make it out of bed. Are there any adaptations you would make to your protocol for people who are super low on energy?

    • Dr Ben August 5, 2012 at 7:16 am # Reply

      Hi Matt –

      Be sure the Cerefolin is not too strong for you – please read my Methylfolate Side Effects article.

      1) I mean stay away from ‘synthetic forms of folic acid’ – natural forms in foods is just fine for many people. Some people still do not do well with it – but in general – most do. Simply avoid the enriched folic acid foods.

      2) Eating every two hrs with some form of protein, chewing your food very well before swallowing and limit drinking with meals are very important points.

      Be sure to eat a bit of protein before going to bed also to help support your blood sugar levels.

      3) Have bright light bathe into your room in the AM to help eliminate the melatonin. Getting a Sunrise Alarm Clock can help you wake up.
      In terms of supplements:
      Pantothenic Acid 500 mg with breakfast may help support your adrenals which are important in ‘waking you up’ via cortisol secretion
      – 1/2 to 1 capsule of L-Tyrosine upon waking to help the excitatory neurotransmitters and your thyroid to work more efficiently.

      These recommendations should help ;)

  36. Grey August 9, 2012 at 2:42 pm # Reply

    Dr. Ben.
    Although overwhelmed with all this information and protocol I am grateful that you are making this available. I have 3.5 yr old boy that has just been diacgnose with the C677T mutation. Do you have a protocol specifically for children and also should he follow a specific diet. I am desperate to start on a plan for him but I feel lost in all of this. After reading some of you material I am so glad I never gave him any vaccines. However he has had severe candida issues.

    Thank you so much,

    • evy August 9, 2012 at 9:19 pm # Reply


      I have a daughter (19) with two mutations. We did give her the standard vaccinations for the first year of her life (which I regret) but am very glad we did not continue. I am convinced that she would be much, much worse off had we continued with the regularly scheduled vaccinations :(

      Does your child consume sugar in any form? That would be a great place to start for the candida, with eliminating sugar :) My daughter went from major candida overload to non existent candida in 2 months of being completely sugar free (all forms of sugar except we did keep fruit in her diet-not excessively, but some nonetheless), and we did use stevia as our only sweetener.

      I would highly recommend this book

      for anyone with ANY allergy/health issues, no matter what the age of the person and DEFINITELY for someone with a young child with health issues, that you might be able to fortify, strengthen and give all the possible health advantages to your little one as he is growing up.

      This book has amazingly UNDERSTANDABLE information and explanations that clearly define what and how digestive issues impact health. Don’t worry about the title (the Gut and Psychology Syndrome might seem strange, but it’s a must read!

      I hope you get good answers to your questions to help you with your child’s health!


  37. Jamie August 9, 2012 at 5:04 pm # Reply

    Hello Dr. Ben:

    Thank you for your work and the information you provide. I was interested in scheduling a consult with you, but I see your recommendations for starting the protocol first, so I will start there. I have a few questions, though.

    I discovered I am homozygous for C677T about a year and half ago when my husband and I were trying to have a baby and we had two (early) miscarriages. I was told it wasn’t “a big deal” and that I just needed to take folic acid, 5000 mcg/day. I did a little research, but not much, I guess, because I never saw this site or a lot of other things I see now.

    I did end up having a successful pregnancy, and despite high blood pressure (no pre-eclampsia–all labs & amniotic fluid remained great, and my blood pressure is back to normal/low levels again now), was able to have a great home birth with a CNM. My sweet baby is 6.5 months old now. I did the high folic acid throughout pregnancy. I got back to thinking about MTHFR, however, when my baby’s stools, which had been a little mucousy but mostly semi-formed, normal exclusively breastfed baby stool, turned on a dime to runny, almost all green mucous stools only once a day after his first vaccinations at 2 months (which we haven’t and don’t intend to continue). I looked first at food intolerances. Though I’ve eaten pretty healthy for years, I think we’ve come to a new level of health with cutting out dairy, soy,and very limited gluten. We also eat very limited processed foods (do by some almond milk when I don’t have time to make it, granola and things, but I try to buy those with only coconut oil, raw versions, and organic). I saw a few things improve with my baby–although it’s hard to see because he’s pretty happy–but not his stools. I have been working to heal both of us (he is still exclusively breastfed, although I am moving into solids, and have started with some sauerkraut juice from lacto-fermented sauerkraut), and this all brought me back to MTHFR, when a holistic IBCLC told me I should be taking folate instead of folic acid.

    I can’t say I notice a ton of symptoms. I am generally happy and healthy, although I do a lot of work to stay that way: organic foods, non-processed foods, yoga, running, meditation, fun, natural cleaning products. I have generally avoided toxins for years, but I have had slip-ups, of course. Possible symptoms: restless legs, occasional insomnia, hard time falling asleep, anxiety, some GI issues, frequent urination. Also, my dad had alzheimer’s, so I am paranoid about that connection. I also had a strange bout of childhood epilepsy when I was little which was never connected to anything. I once had a very bad reaction to nitrous oxide at the dentist–felt very sick and out of it. I don’t drink very much alcohol anymore–occasional glass or half glass of wine–but times when I drank more, I’d feel pretty bad.

    My questions for you are:

    -Supplements: I just switched to the Thorne Prenatal from New Chapter Organic Prenatal, based on your recommendation and because I realized NC contains soy. I also have been taking 5000 mcg of folate a day, and fish oil, a high-quality dairy-free probiotic, cal-mag citrate. I am also taking zinc, because I had keratosis pilaris pop up right after giving birth, and I was hoping that zinc would help (it hasn’t). Should I continue taking those, switching to the krill oil you recommend, or should I just quite everything except for the prenatal and then work down the list you offer. When I took the prenatal today, I did feel a little sick, which didn’t happen with the NC. I bought the MTHFRade ingredients from the HealthE Goods site today, too.

    -My baby: I was planning on getting my baby tested. I see you recommend I do this through his pediatrician, so I’ll ask and if not I’ll order the test from you. Besides the stool issues post-vaccine I described, he has an umbilical hernia and possible posterior tongue tie and very low upper lip frenulum attachment. We are exploring getting his tongue and lip released. We also had some immune system screens done, and his IgG antibodies were tested and they were low. Could that be consistent with MTHFR?

    -Do you recommend I have the other blood tests done, like testing homocysteine levels, before I talk to you? If I can’t get a local doctor to test me for those, I would appreciate you letting me know what you would recommend I order from you to start.

    Thank you again for your time and work.

    Kind regards,


    • Jamie August 10, 2012 at 7:51 pm # Reply

      Dr. Ben, I also forgot to mention I have had pretty bad joint pain on and off since I had my baby. I started taking the Thorne B-Complex#6 in addition to the other stuff I am taking. That was at the suggestion of a chiropractor who thought maybe the folic acid I was taking was affecting the absorption of other vitamins and minerals. That chiropractor also advised me to take my fish oil and cal-mag citrate at different times to help with inflammation/joint pain. It did go away for awhile, but the last few days (since switching to the Thorne prenatal??) it’s back and I am feeling quite tired. Thank you for your advice.

    • sarah March 13, 2015 at 6:02 am # Reply

      I’d love to know if your baby’s stool ever changed back to yellow from green. I’m in same boat (minus vaccine part). I’m a “crunchy” or “granola” person. Eat healthy….buy organic when possible….

      My 7 week old was born w sacral dimple, tongue tie, lip tie….and NOW this stupid green poop! He’s had it about 4 weeks. I’ve tried block feeding in case he can’t empty the breast and cutting out dairy. I have been researching and wondered since he has those things if I happen to have the mthfr gene. Also family history of autoimmune, depression etc. I’d type more but I’m doing it w one hand while breastfeeding. Lol. Did you ever find out why youre having (had) green poop or link it to mthfr. I can’t find answers and midwife is stumped.

      • Tiffany March 14, 2015 at 7:01 pm # Reply

        Green poop is a symptom of getting too much foremilk and not enough hindmilk, typically. Try nursing on one side exclusively for each feeding.

  38. Jen August 21, 2012 at 8:20 pm # Reply

    HI I read so much info here and listened to your podcast and am confused. I am TTC again (we have one daughter after 2 previous miscarriages) I was on lovenox and neevo in my last pregnancy. I have been taking the sublingual b12 and active forms of b6 and a multivitamin (your chewable one) but not sure if I need to change this now that I am TTC. Do I need a prenatal and if so which one? Do I need more folate? I read that you said to avoid the neevo so just want to make sure I am taking things that will be helpful when TTC. Also I ordered the NAC. Is this safe while TTC? thanks so much. Jen

  39. Brianna August 26, 2012 at 1:21 pm # Reply

    I just have a few questions about the above protocol. I am hetrozygous for both C677T and A1298C. My doctor has put me on a protocol but after reading your post and the comments, I feel like the symptoms I am experiencing are overmethalation. I was told they were due to the dye off or detoxing. I have been on my suppliments for 5 weeks, and the symptoms are only getting worse. My doctor has me on Sam-e, which I have read that may not be good. I am currently taking

    Folate (as 6S – 5 – Methltetrahydrofolate) 3000 mcg

    Sam-e 800 mg
    TMG (as anhydrous betaine) 1200 mg
    (both of these together in a powder form)

    Phosphatidylserine 300 mg

    (the following all in one pill)
    TMG 1000 mg
    Folate (natureFolate blend) 2400 mcg
    NAC 200mg
    Riboflavin 100mg
    vit B-6 (as Pyridoxine Hydrochloride 40mg; Pyridoxal -5-Phosphate 10mg)
    Vit b-12 (as Methylcobalamin) 1000 mcg
    Magnesium 20mg
    Zinc 10mg
    Choline 200mg
    Serine 200mg

    Pro-biotics twice a day (5 billion cfu)
    Pre-biotics twice a day (inulin)

    Chromium 900mcg
    (also includes 150 mcg Taurine, 300 mcg Vanadium, 300IU Vit D,
    30 mg zinc, 3 mg manganese)

    I have not tried juicing or the Niacin. I just feel like I am sedated all of the time, along with anxious, jettery and irritable. I also have celiac disease, so I know absorption is also an issue. I have been trying to imporve gut health with pro and pre biotics as well as avoiding all gluten, wheat, dairy, and sugar for 3 years. I had to go on antibiotics for 10 days recently due to a staff infection from surgery I had 3 monts ago. I just feel lost, and am trying to understand how what I am taking equates to your protocol.
    Thanks for listening

    • Dr Ben August 26, 2012 at 7:34 pm # Reply

      Brianna –

      The potential for overmethylation, anxiety and irritability are definitely possible here from seeing how much you are taking – which is a lot.

      Do talk with your doctor about your concerns. It is not a detox reaction in my experience – you are simply overdriving your neurotransmitter production and increasing methylation past the healthy point.

      • Brianna August 30, 2012 at 1:19 am # Reply

        Thank you for your quick response, and all of the easy to understand information that you put on this site. I actually started my doctors protocol over a year ago for this disorder, but gave up after few months becuase I felt to sick, and because I really didn’t understand it. Your website is a HUGE help in my understanding of what is happening, and the importance of correcting it. I did talk to my doctor, and we decided to take a few steps back off of what I was taking. We talked about the potential interferiance that metals could have. Last year I had so many health issuess, and she found that I had Celiac disease, and almost no healthy bacteria in my gut. She also found after a heavy metals test that I was extremly high in tin and copper. The acceptable referance range for tin was less than 2.04, and my results showed 17.62. At the time she wanted to work on diet and healing the gut before starting a detox, and something we both forgot about. So I started a detox protocol today, and hopefully at the end of that, I will start to feel better. I read your article about the effects of over and under methylation, and how it is a delicate balance, and to introduce one nutrient at a time. I agree with that, and feel that would be a better way for me to start the methylation protocol after I have finished detoxing. Thank you for helping me connect some dots that I wasn’t seeing before

  40. fchiramel August 28, 2012 at 4:37 pm # Reply

    Dr. Ben,

    Firstly, thank you for the good work you are doing in bringing more awareness about MTHFR mutations!

    I don’t know if I am missing it but I do not see much info here on support / supplements for homozygous A1298c mutations. I did see discussions on how the mutation affects body biochemistry and metabolic pathways, and also support / Rx for the compound heterozygous mutation, but nothing for the homozygous A1298c itself.

    I am in the medical field and agree with you that there is very little information we have about these mutations.

    I have taken a one hour appointment with you and it seems your earliest available date is 9/19. I would have liked to order some supplements in the meantime and see if they helped me.

    Thanks, and look forward to talking to you!

    • Tina April 14, 2014 at 11:46 am # Reply

      Dear Dr Ben,
      I live in country NSW, Australia, and have a 4 year old son who has the test results of A1298C Homozygous. He is regularly sick (ear, chest infections) and has had 16 doses of antibiotics. We follow most of your dietary health suggestions (we grow our own organic food etc). But I am not clear on what type of supplements it would be appropriate to buy for him?
      Many thanks.

  41. Kelly August 29, 2012 at 2:21 am # Reply

    Hello Dr. Ben,

    I’m heterogeneous for 677T.

    I haven’t seen this addressed anywhere, so since you’re the expert, I’m wondering if it’s okay to take vitamin K2 along with vitamin D? It’s my understanding the vitamin K regulates clotting…doesn’t increase it or decrease it, but regulates it.

    Is this correct, and if so, would it be okay to take along with the vitamin D?



    • Anita October 21, 2012 at 3:29 am # Reply

      I would also like to know the answer to this question and weather it’s ok to take vitamin k2 for bone health. Does it have the same clotting factor as K1?

    • novamtnr February 6, 2015 at 6:12 pm # Reply

      I would also like to know if it is safe for homogenous C677T to take vitamin K2(mk-7)? my vitamin D is low at 28 so my doc recommended taking vitamin D3. But I’ve been reading that when taking D3 you should take vitamin K2 to facilitate the D3.

      • Dr Lynch February 6, 2015 at 6:27 pm # Reply

        You need to ask your doc about this. Some can take K2 and some docs may want their patient to avoid it.

        You can also get K2 from dark leafy greens.

  42. Andrea September 11, 2012 at 6:25 pm # Reply

    I have one copy of the C677T mutation and one copy of the A1298C mutation – so I am compound heterozygous according to the lab results. What supplements/dosages would you recommend for a person with this situation? If I have chronic bothersome mood, dizziness, and headache issues, is 10 mg methylfolate too much to try? Thanks!

    • Lynn_M September 12, 2012 at 1:50 am # Reply

      Dr. Ben has laid out a C677T protocol in the articles section, and he seems to be recommending that for any kind of MTHFR mutation.

      10 mg. methylfolate is much too high to start with. Try starting at 1 mg. Some people need to start with just crumbs. If you’re taking methylfolate, you also need to take methylcobalamin, otherwise the methylfolate just gets wasted because of a phenomenon called methyl trapping. Methylcobalamin is a necessary cofactor for methylcobalamin.

  43. Paige September 19, 2012 at 1:08 am # Reply

    Just got test results back today – my whole family has one or more MTHFR mutations! My question for now: My 8 year old son is homo c677t. Is the protocol you lay out here suitable for an 8 year old? Can I follow it for him or do I need to decrease amounts or leave out any particular supplements?
    Thanks in advance for your help! You are literally one of the only places we can turn for information on this topic!

  44. Amee September 20, 2012 at 1:13 am # Reply

    Hello: I have questions about the Basic Protocol. I was recently told I have rs1801133 T/T. (Am I correct in thinking this is the same as homozygous C677T?)

    I have had symptoms all my life that may be related and that have recently gotten worse. My MD has prescribed Deplin, starting with 7.5 mg/day.

    I am interested in trying this basic protocol, but wasn’t sure I understood it correctly. Is this correct:

    1) use Active B12 5000 for only 7 days (one must buy 60 lozenges only to use only 1 and 2/5 lozenge total)? if well tolerated:

    2) use Active B12 with Methylfolate for approximately 12 days (7.5 lozenges out of a bottle of 60, but can be added back after full protocol is tried). If well tolerated:

    3) use HomocysteX for 7 weeks (total 122.5 capsules). If well tolerated:

    4) Use HomocysteX Plus for up to 11 weeks. At the highest recommended dose, one would get 4.8 mg/day, less than the lower dose of Deplin.

    I would greatly appreciate it if someone could let me know if this is a correct interpretation?

    Also, if I have symptoms, does it make sense to start at a higher dose or skip any of these steps, or stick with the recommended protocol? 5 months seems like a long time to know if one will get relief.

    Also, is it possible that I could go through this 5 month protocol and still need more methylfolate, as recommended by my MD (7.5 or possibly 15 mg/day)?

    Thank you!

  45. Jessica September 23, 2012 at 5:24 am # Reply

    Hi Dr. Ben

    Thank you for all your hard work and great information. I am a 36yo and recently found out that I am compound heterozygous (one copy of C677T and one copy of A1298C). I have 9 other sibling and we have all been sick from a very early age with many learning disabilities. I became very sick this last year and after many doctor visits I finally have answers. I have been diagnosed with PCOS, Fibramylagia, Cervical Hyperplasia, IBS, and a lazy gallbladder. I also had a very hard time getting pregnant and a miscarriage. I kept thinking they were all related, but could not figure out how. I read your protocol for C677T and wanted to know if this is the same protocol for A1298C or should I be doing something different. I started on krill oil, CoQ10, probiotics and Turmeric. Should I be doing something different? Again thank you for all your hard work and I look forward to be one my way to regain my health.

  46. Laura October 1, 2012 at 5:18 am # Reply

    Hi, How could the MTHFR gene influence a 16 y/o girl who for years has had Daily Chronic Headache plus migraines that are worse 1-3 days per week??? She has had a lot of work on her diet and testing as well. She was high in Uranium but fairly low in the other heavy metals…

    I am desperately looking for something that could be adding to the constant pain she lives in.


    • evy October 24, 2012 at 8:28 pm # Reply


      Which genetic mutations does she have?


  47. Dan October 24, 2012 at 1:36 am # Reply

    Can you say this is a crock of shit? I can. There is only 50 people in the world that specifically have the MTHFR blood mutation. You may have clotting problems but it aint MTHFR. I am ONE of the 50 known cases IN THE WORLD! There is no cure. there is no diet plan. there is almost NOTHING known about this mutation in the blood. You take blood thinners and hope you dont clot again… Thanks for being full of shit everyone.

    • Jenny October 24, 2012 at 5:15 pm # Reply

      Oh Dan, it’s too bad you are so angry. I too am one of the known MTHFR mutations, stroke at age 33, super high homocysteine levels, placental abruption with my son, lifetime of blood thinners. And, I happen to know many many more people who have the disease.

      • evy October 25, 2012 at 6:38 pm # Reply


        Sorry to hear about your health problems. What does “known MTHFR mutations” mean?


    • evy October 24, 2012 at 8:27 pm # Reply

      Dan, I am curious about your comments here. I was just tested and came up positive for both genetic mutations. Are you saying that when one tests positive for MTHFR that it is a false positive? What kind of test did you have done that concludes you have one of the only 50 cases?



      • Allie October 24, 2012 at 9:41 pm # Reply

        I wonder if Dan was maybe diagnosed some time ago – when he may have been one of the first 50 found, and there would have been little understanding how to treat it. Either that or he may be talking about one of the other lesser known MTHFR mutations apart from the 677 or 1298 that are most recognised? One way or another, all that lifestyle info in the article above is bound to help anyone, whatever their genetic status so it is a shame that he simply rejects it. Plus, trying the supplement regime and seeing if it makes a difference could well help him too. Even positive attitude would help, but maybe he has been so convinced that there is nothing that he can do, that he has lost heart – in which case I would encourage him to check out all the latest research and maybe give treatment another go in the light of current thinking.

    • Dr Ben October 26, 2012 at 11:09 pm # Reply

      Dan –

      Your MTHFR is clearly demonstrating itself through your angry post.

      Your information is grossly incorrect.

      A ‘tiny’ bit of research will prove you wrong.

      MTHFR is highly prevalent. There are various degrees of the MTHFR mutation.

      You likely have the Severe MTHFR Deficiency which is indeed rare.

      While there is no cure for a genetic mutation, there is a lot you can do to support the severe defect.

      We’d all benefit as you’d be a more cheerful person.

  48. Michelle October 25, 2012 at 10:13 pm # Reply

    Dr. Ben,
    Where are you getting your information? Are you a real doctor? Individuals with elevated homocysteine should NOT avoid folic acid, especially if they are pregnant, they should be supplementing their folic acid intake. You are misleading people, in possible dangerous ways. Do you research.

    • Dr Ben October 26, 2012 at 11:04 pm # Reply

      Michelle –

      Read the other articles on this site and you’ll learn why I say to avoid folic acid. This is a site about the MTHFR defect which causes low active forms of folate. I recommend the form of folate which is known to lower homocysteine.

      There is no need for being insulting.

      I got my medical degree from an online 2 week course from Burma. It was a very challenging course.

      Kidding aside – Yes I am a ‘real’ doctor.

      • Summer Bonnet January 19, 2013 at 6:22 am # Reply

        With all your hours of research it is good to see you still have a sense of humour! (I could just imagine the intensity of that course)

      • Debbie G. February 20, 2013 at 4:04 pm # Reply

        A sense of humor is paramount in healing yourself! Way to go Dr. Ben! Handled with class and style.

  49. Janae October 27, 2012 at 5:37 am # Reply

    Dr. Lynch,

    After having dealt with chronic candida issues, leaky gut, liver congestion, hormonal problems, and chemical sensitivities (which I understand is all intimately intertwined) and dealing with it on my own for about 4 years, I ended up finally seeking help from a naturopath. She tested me for this condition and it turns out I am a homozygous mutant. I no longer consult my naturopath, being that I no longer live in Vermont and receive free state healthcare…so, my questions are as follows…

    I have been taking Methylguard since July. My doc started me out taking 4 caps daily for about a month, decreasing down to 2 caps per day. I didn’t really feel much difference in the way that I felt…but it could have been the humidity of Vermont and Ohio that worsened my candida issues, who knows. I’m now back on the west coast, and liking the climate much better. Anyway, I decided to up my dosage of the Methylguard to 3 caps per day, which is still less than the recommended dose on the bottle, which is 6 caps per day. I guess I am needing to know if I should continue upping the dosage, or should I just take more methylfolate?

    It’s now the end of October, and I still struggle with insomnia, brain fog, intense food cravings (depending on what time of the month it is), depression, chemical sensitivites etc. I’ve got some sort of constant dull pinching sensation in my liver region, so it’s clear I’ve got congestion there. Andrea Moritiz’s liver cleanse was suggested by my colon therapist over a year ago, and since then I’ve done a few cleanses and they seem to help. I always get out “stones,” but it sounds like there is some contention within the medical community about whether or not these are legitimate stones. I’m confused myself. I know I feel better afterwards, but I’m not sure if it’s because I’ve just crapped out every last thing inside of me, resulting in a profound relief from any sort of bloating. What is your thinking on the liver cleanse?

    I’m also caught in a sort of conundrum. I understand that it’s hard to process a good amount of fat and protein in the diet when the liver is distressed. However, it’s hard to process any sort of starch or carbohydrate when one has leaky gut. I have been unable to tolerate even non-glutenous grains because for one, I want to binge on them, and for two they seem to ferment pretty nicely in my gut, resulting in bloating and bubbly stools. Raw vegetables also ferment in my digestive tract…so I’m stuck eating pretty much just organic meats, soft cooked vegetables, coconut oil and maybe some ghee. Can’t really even do nuts or seeds anymore. I need a lot of fat and protein to keep my energy up, however, I feel I have trouble processing fat sometimes, especially in conjunction with protein. Sometimes there will be an oily sheen in the toilet, suggestive of my inability to properly digest fat. Any thoughts on this?

    Do you believe one can live in this toxic world, and still be able to detox without an environmental control unit? Because I feel like I’m constantly being bombarded by scents and car exhaust and what have you…which really makes the road to healing seem insurmountable. I’m at the point of really needing 10,000 dollars so I can spend some time at the environmental health clinic in Dallas. I’m only 24, I’d like to be free of chronic health problems.

    • Dan2 (not the same Dan above) October 29, 2012 at 10:40 pm # Reply

      I have a lot of trouble digesting fat as well, and someone suggested I try ox bile extract. It worked for her. Also, I’m low in glycine, which helps form bile too.

      I also used to eat nuts, seeds, and related oils, but have found (through Ray Peat’s and others sites) that they can damage the mitochondria and suppress thyroid function due to their high omega six levels. You might try googling “Ray Peat, PhD”, and see if you can find any alternative suggestions.

  50. Dan2 (not the same Dan above) October 28, 2012 at 8:25 pm # Reply

    Dr. Ben,

    You stated above that vitamin C destroys methylb12 if more than 500mgs is taken. I can’t find any reference or study that confirms this and believe I have subclinical scurvy, so may need to take high doses of C.

    Do you have a reference for the C-methylb12 interaction?

    Thanks in advance,


    • Dr Ben October 29, 2012 at 9:03 pm # Reply

      Hi Dan2 –

      Advanced Nutrition and Human Metabolism, 3rd Ed., Chapter 9, Vitamin B12, page 258.

      • Dan2 (not the same Dan above) October 29, 2012 at 10:34 pm # Reply

        Thanks so much for your reply, I really appreciate your taking the time to find the reference.

        Unfortunately, google books — no matter how hard I try — won’t let me access that page. Chapter 9 (in the current 2012 edition) starts on page 307, and I could find info on b12 on pages 357 and 359…but ‘page 358 isn’t part of this preview.’

        I guess the main point is to take them far apart.

  51. MIchelle November 1, 2012 at 3:26 pm # Reply

    Apparently I have the homozygous form. I didn’t know until 2 years after testing and someone just recently finally looked at results. Does everyone need treatment for this? I never even knew I had a problem. i just needed testing because of stroke history in my family. Thanks!

  52. Amy Lytle November 7, 2012 at 11:52 pm # Reply

    Hi Dr. Ben! Thank you so much for your website! I have been trying to balance your basic protocol since this summer and doing better. Recently though, I have noticed the palms of my hands and the skin around my mouth starting to turn slightly orange. Could this be a sign that I’m not doing something right? Any suggestions on where to start? Thank you!

    • Dr Ben November 7, 2012 at 11:55 pm # Reply

      Amy –

      How many carrots are you juicing or eating? Could be excessive vitamin A or carrot intake.

      If so, stop eating vitamin A and carrots until this goes away.

      This what is going on?

      • Amy Lytle November 8, 2012 at 12:16 am # Reply

        Actually I don’t consume many carrots or juice at all. I wish that was it!

        • Dr Ben November 8, 2012 at 12:26 am # Reply

          Amy –

          Please visit your primary care physician and have them evaluate you.

          Consider having them check your liver function, kidney function and blood levels of beta carotene.

          • Amy Lytle November 8, 2012 at 1:04 am #

            Thank you so much for your quick response and reply! I was hoping that there could be something simple I was missing but from what I am reading and gathering there may be a problem. Thank you again so much for your help and work on this incredible website!! You are helping so many families and we can’t thank you enough!

          • Caitlin November 12, 2012 at 12:55 am #

            Hi Dr. Ben, I am wondering if you can tell me if taking a food based B vitamin is OK and as effective as taking a methylated form. The ingredients are listed as “folate” (not folic acid) and “B12.” This is from Pure Synergy. I am homozygous for MTHFR. Thank you for this site!!!

          • Dr Ben November 13, 2012 at 10:57 pm #

            Caitlin –

            Food based B vitamin may be ok – but I cannot say with confidence that it would be ok. Methylfolate is very sensitive to destruction and there are many types of food folate.

            If you are taking a food based B vitamin, I’d at least take some true methylfolate and methylcobalamin to support it.

            Your symptoms are also telling. If you feel better on the food folate and b12, then perhaps that is sufficient. :)

  53. Natalie November 11, 2012 at 3:17 pm # Reply

    Hi Dr. Lynch,
    I am a bit confused. I have 2 copies of 677C-T. Is this the same as 677T and if not what is the differance. Am I homozygous or heterozygous? Which protocol should I follow?

    • Dr Ben November 13, 2012 at 11:00 pm # Reply

      Natalie –

      You are homozygous for the 677 mutation if you have 2 copies. One copy = heterozygous.

      It can be written like this:
      – 2 copies of C677T
      – 677TT
      – homozygous C677T

      Those are the appropriate ways to specify a homozygous C677T mutation.

      You may read and consider following the protocol above – but please – work on this with your doctor. That is a must. Everyone is different. While some people feel amazing following the above protocol, others can get worse.

      • Caitlin November 14, 2012 at 12:42 am # Reply

        Dr. Ben, Thank you for your quick response regarding the food based B vitamins. I’m curious about the magnesium stearate and silicon dioxide in the chewable b’s. This isn’t something to avoid?

        Thanks so much. I’m in the middle of watching your presentation and have found it very informative.


        • Dr Ben November 14, 2012 at 1:04 am # Reply

          Caitlin –

          Silicon dioxide = sand

          Magnesium stearate is not ideal in powders, capsules or standard tablets. I am not a fan of it.

          I use magnesium stearate because I have to due to the manufacturer needed it for chewables and lozenges. However, it is on my list to work with a lab and eliminating the magnesium stearate from those.

          I do find that people do respond to the chewables and lozenges – thus they are receiving benefit.

          In terms of harm, neither of these ingredients are an issue. The issue is absorption of nutrients – and if one chews or allows the tablet to dissolve slowly, then the absorption factor is a non-issue.

          The problem with magnesium stearate comes when it is in a capsule or tablet and simply swallowed. It is then harder for the body to obtain the nutrients.

      • Natalie November 14, 2012 at 12:39 pm # Reply

        Thanks for getting back to me. I have been to integrative doctors, and even they dont know what this is or how to treat it. I am really hoping you will decide to take new patients again. There are many of us who need your help. I also have one copy of the COMT gene. Can you tell me how to regulate this along with the C677T? I need to know ways of lowering ephinephrine and estrogen.

      • Natalie November 14, 2012 at 2:17 pm # Reply

        I read and article from your website about a post menopausal study regarding higher incidence of breat cancer with those with the 677TT. In the article they compared 677TT, along with 677CT. The article said that breast cancer was a bit lower with 677CT. This is part of the reason I was confused. Can you clarify the differance from the study? In my genetic test, it read C677T so I was hoping I am in the slightly lower risk group.

  54. Rachel Shelton November 12, 2012 at 5:06 pm # Reply

    I just found out I have homozygous c667t, I have no idea what to eat any more. A couple years ago I was found to have a yeast and dairy intolerance. I try to follow it but I get very bad cravings. Everything you listed to not eat is all I have left to eat. Can you recommend a link or meal plan for someone like me?

  55. Lisa November 16, 2012 at 7:37 pm # Reply

    My ND wants me to go on a detox and elimination diet before addressing the MTHFR. Agree?

    • Dr Ben November 16, 2012 at 7:55 pm # Reply

      Lisa –

      Elimination diet – totally agree.

      Detox. Depends. Depends on how you define detox.

      If your ND is defining detox as avoiding toxins and xenobiotics – then absolutely.
      If detoxing means healing and treating the gut – absolutely.

      If detox means supplementing with glutathione, sulfur supplements, chelation, detox powders and so on, then no, I don’t agree.

      If you detox prior to addressing MTHFR, then you are not supporting your own internal detoxification methods.

      I can see their point that if your own internal detoxification methods are not functioning, then give passive means to do so.

      I believe that if one alters their lifestyle, diet and heals their gut, the toxic load will drop dramatically and on its own speed.
      If you then start supporting the MTHFR mutations after the above are accomplished, then you will increase the speed of detoxification a bit faster.
      This is tolerated by your body.

      If you detox hard with supplements and chelation, then you may find yourself quite ill as you are mobilizing the toxins but not getting them out.

      You have a lifetime of toxins and xenobiotics in circulation – we all do. If you move them out quickly with MTHFR defects, you will likely become ill. I see it over and over again.

      • Lisa November 16, 2012 at 8:59 pm # Reply

        Thank you for your response! I agree and that is why I asked. Very sensitive to supplements. Tried 1/4 Metanx for five days with a bad reaction – headache,pounding heart and anxious/jittery. I am more than a little worried about the detox. I have been gluten free with very little dairy. Clean and organic as much as possible. I am on a probiotic and fish oil. ND wants to use herbs in CleanseMax and LiverMax by Advanced Naturals. I am a big believer that given the chance the body will do as it is designed to do. What to do?

        • Lisa November 16, 2012 at 9:05 pm # Reply

          One more thing…He said that when I tried to take the Metanx (i also tried New Chapter Raw Code which gave me the same reaction), my pathways opened up and my body tried to dump the toxins too fast. That is what caused my poor reaction. i see both sides and am stumped on my next step. Help, please!

          • Dr Ben November 17, 2012 at 1:10 am #

            Lisa –

            Detoxing too quickly may be one aspect; however, given that methylation affects so many things – that is not the only possible explanation.

            You may have other methylation defects which are causing you to be sensitive – such as COMT, MAOA, CBS, SUOX, etc

            You have to start with foundation first and be very dedicated.

          • Kelly November 17, 2012 at 2:08 am #


            I went through hell in 2011 when a doctor ‘overprescribed’ several different types of folates and b12’s — took a whole year to recover.

            Some of the so-called ‘healthy’ diets can also create problems because they may contain too many natural salicylates, which can interfere with methylation, so sometimes ‘clean’ doesn’t always mean better…although I know what you mean.

            I finally saved enough $ to get the Yasko genetic panel, and then was even more confused. I was able to consult with an RN who specializes in interpreting the stuff, and was very grateful for her help, but some of what yasko recommends is very controversial. I personally know someone who has the so-called “CBS upregulation” and yet she has improved markedly without avoiding sulfur or sulfates, in fact she increased them and did well.

            All that being said, you may be reacting to too large of a dose, and/or to one of the components of the metanx. I found I could not tolerate ANY b6 until I increased my b2 levels, (B2 is also involved in methylation, and often neglected), but rather than adding b2, I personally would start with each ingredient separately, and in small doses — for example, start with a tiny amount of methylfolate or folinic, and then 2 weeks later add a small amount of b12, etc., and go from there. That way, you might be able to figure out what precisely is causing the strongest reaction.

          • Lisa November 17, 2012 at 3:10 am #

            Ugh – so you are both telling me to start with a single B – either B12 or methylfolate and work from there. Do I do the detox at all – is there any reason to detox if the MTHFR is addressed? For sure do the elimination diet though. Thanks so much for all your help!

  56. Lalla November 17, 2012 at 9:34 pm # Reply

    dear doctor Lynch

    I would like to submit an application for a 40 year old woman with these results in search of a pregnancy

    The C677T mutation in homozygous form: is a cause of no conception?

    The C677T mutation in homozygous form can cause problems on the basis of yours experience, fertilization of the oocyte and subsequent taking root?
    On the basis of a direct experience of an Italian couple, after countless attempts ( 10 year and many ICSI) to medically assisted fertilization always gone wrong, independently discovered the C677T mutation in homozygous form of the lady who practiced the protocol of multiple abortions’ at the stage of conception. ( in Italy this treatment protocol is applied only after multiple miscarriages ).
    It ‘possible that high levels of calcium, homocysteine ​​associated with mutation c6777t be the cause?
    No conception ,in some case,can be seen as a form of micro abortions fertilization?
    These values ​​may show the cause?

    igA 148
    IgG 1418
    IGM 111
    IG TOT 10.7
    ANA antinuclear neg
    cardiolip IgG 2 <10
    cardiolip IgM 1 <7
    C4C C3C 1.16 0.93 to 1.88 0.30 015-048
    homocysteine ​​8.9 5-13
    Calcium 2.61 2.02 -2.60
    mut V R506Q fatt absent
    mut fatt II prothrombin 20210A Absent
    MTHFR C677T mutation in homozygous form

    Lalla from italy

  57. Lisa November 18, 2012 at 7:27 pm # Reply

    Please explain “gut health” and how to achieve it. Thank you!

  58. Zoe November 22, 2012 at 12:12 pm # Reply


    I have c677t homo mutation.

    I have candida overgrowth, would you recommend taking NAC?

    I read that NAC is not recommended with candida.

    Many thanks.

  59. Becca November 30, 2012 at 1:03 am # Reply

    Hi Dr. Ben :)

    First, let me say that this is by far my favorite site upon being diagnosed with MTHFR deficiency and homocysturnia yesterday. Just reading your protocol and all of the QA’s has been extremely helpful. LIke you, I am a strong believer in lifestyle being a healer of the body. It’s refreshing to come across a physician with the same conclusions.

    I have some questions about my diagnosis. I had two extremely healthy and uneventful pregnancies. One in 2006 and the other in 2008. Both my children are very healthy and have zero health issues. I miscarried at 12 weeks in 2009 and twice this year. Upon having three consecutive miscarriages, my doctor ordered a “recurrent miscarriage panel”. I went in yesterday for the results and got the diagnosis. My question is how in the world I could’ve had two healthy pregnancies with having MTHFR and homocystinuria. Did something trigger the MTHFR and homocystinurnia? From what I’ve read, I was born with it. Sencond, upon getting pregnant with my first son, I got a cluster of spider veins on the right side of my upper calf that, at times, feels like a bruise. It can be sensitive to the touch but it’s off and on. Upon getting pregnant with my second son I got a very large, bulky vericose vein in my right leg that starts very high on my upper thigh and travels down and around my knee cap. In recent months I’ve had more pain and what feels like RSL in my legs….especially the right one. I had a few days of sharp pains on my lower right leg (calf area). This caused me to start doing some research. Needless to say I came away terrified that I had deep vein thrombosis or some other serious vascular problem. I let it go until my diagnosis yesterday. The puzzle pieces started to fit together and I’m realizing that the two may be connected since MTHFR is linked to vascular and arterial problems. What do you suggest?

    Thank you!

  60. Becca November 30, 2012 at 9:19 pm # Reply

    Hi Dr. Ben –

    One important thing I forgot to mention yesterday. My diagnosis is compound heterozygous for C677T and A1298C…

  61. Jess December 12, 2012 at 10:11 pm # Reply

    Why such minuscule amounts of protein? Do you mean beans, nuts and legumes as well, or just animal protein?

    “23. Eat smaller, but more frequent meals, throughout the day with some form of protein.

    24. Limit protein intake to approximately 0.7 grams protein per kilogram of body weight.”

    So, should I split my 1.6 oz of protein between 3 or 4 meals?

    • Dr Ben December 13, 2012 at 6:09 am # Reply

      Jess –

      If you do the math, it is not about how many ounces of pure protein you are eating – it is how many grams. No one measures how many ounces of pure protein to eat in a day.

      A 100 kg person should approximately eat about 70 grams of protein if their kidneys and liver are functioning well.

      We eat too much protein as a society and need to watch it.

      Watch the video ‘Forks over Knives’

      There is some truth to what they say in that video – and of course – there are some inaccuracies as well.

    • Kelly December 13, 2012 at 6:16 am # Reply

      That does seem to be a ridiculously low level of protein that couldn’t possible support regeneration. No one I know is eating such absurdly low amounts, and I know some people who have improved by 60% in less than a year.

      • Dr Ben December 13, 2012 at 6:31 am # Reply

        Kelly –

        It does seem low; however, I think for the majority of us, it is enough. There may be new research out there or clinical data that proves otherwise.

        Here is a protein intake calculator which may be useful for you.

        • Allie December 13, 2012 at 11:12 pm # Reply

          That left me with a question: how much protein is in a piece of meat? I found a calculator here

          Wow! I always thought I ate a lot of meat and perhaps too much, but their ‘easy conversion’ of 7g protein per 1oz of meat means I would have to eat 10 ozs of meat per day. I wish they’d given a gram/ounce conversion too to save me the maths, but that’s nearly 300g. Most of the time I’d be under that.

          • Kelly December 14, 2012 at 12:44 am #

            You’re confused. What you’ve calculated doesn’t equate with the doctor’s recommendation. Still, 10 oz of meat is only 3.3 oz per meal. That’s a very small amount.

  62. Shawn December 18, 2012 at 10:13 pm # Reply

    I am a bit overwhelmed. My son has been very depressed and self harming and is in counseling. The doctor just tested for MTHFR and it came back he is homozygous C6772 (I think that is the number). Now the doctor wants me to give him 5000 mcg sublingual methylcobalamin B12 per day and 7.5 mg L-methylfolate (deplin but generic) per day. He is 17 and was born with cerebellar hypoplasia, missing vermis. The amount of information out there is astounding and I am overwhelmed. Please tell me, am I on the right track with these 2 supplements? And what else should I begin? What else to look for? Should I give him a multivitamin and fish oil too? Any advice would be so appreciated.

  63. Ann December 29, 2012 at 9:23 am # Reply

    Dear Dr. Ben,

    Thank you so much for your research and your informative website.

    I have had 5 early pregnancy losses. After my 4th pregnancy I had the extensive RPL blood panel done and all that came back positive was Homo C677T. I have no other clotting disorder. I have never had blood clotting problems in my life and do not have any MTHFR symptoms. My only problem seems to be my early losses.

    After I was diagnosed my doctor told me to take baby aspirin and Foltx. By then I’d already started reading your site and knew that I should be on lmethylfolate. However, my husband urged me to listen to my doctor. I ended up having my 5th loss, by far the earliest loss, at barely 4 weeks. I then went to my doctor and demanded a prescription for Metanx, and luckily she gave me the prescription.

    I am now 8 weeks pregnant. I take baby aspirin, Metanx, DHA and New Chapter prenatals. My concern is that I am not on Lovenox. My doctor keeps telling me that I don’t need it. When I had my RPL testing done, my homocysteine levels were also checked and they were normal. Based on this my doctor keeps telling me that I don’t need to be on Lovenox or Heparin. Is my doctor correct? Please, can you answer?

    After reading as much as I can about the various MTHFR mutations I am under the impression that compound MTHFR or homozygous A1298 are more involved with blood clots, while homo C677T affects with the absorbing of folate. Am I right about this or am I completely off?

    Thank you so much for your time.

  64. Michelle January 8, 2013 at 12:56 am # Reply

    Hi, my name is Michelle. I am so glad I found this website! I was diagnosed with MTHFR after developing bilateral pulmonary emboli while on fertility meds for IVF. I was on coumadin for six months, then switched to 162mg ASA. That’s it, no other treatment! None of my doctors have mentioned any kind of supplements or special diet. I can’t help but be a little worried that this is being brushed away a little to hastily. I know that my clots were due secondary to hormone meds, but it doesn’t change the fact that this mutation exists and I am concerned about risk of future thrombosis. I know now that this is something that I should be more vocal about with my PCP.

  65. Ashley: compound heterozygous January 8, 2013 at 6:14 am # Reply

    I feel like i see a pattern when i read about persons suffering from compound heterozygous MTHFR. To me it looks like mood problems come up alot…not that many commenters claim compound heterozygous. It looks few and far, but when it does come up i see mood issues being among the complaints.

    I personally have suffered from chronic depression all my life (well, since 5 y.o. which coincided with school). I’ve often been suicidal during that time. I had a pretty long stretch of not being depressed or suicidal for the seven years between my two children. However, right before my first child was born, and right after my second child was born, i felt the full, heavy hand of the death wish. This also seemed to coincide with taking far too much folate. Once stopped, sanity and life returned with gusto and i’m now my true, cheerful self.

    I was diagnosed with MTHFR during my first pregnancy, not because of recurring miscarriage, but because my father had died from his blood clotting disorder that was very troublesome throughout his life, yet lived through something as fatal as kidney cancer. He even survived alcoholism and a whole slew of drug addictions and kicked them aside just a few short years before he died. I have never miscarried, but i did have spotting for a month in the first trimester during my second pregnancy. My mother had the same problem when carrying my sister. They both also suffer from depression and suicidal thoughts. They both have also had clots. My mother is undiagnosed. My sister is heterozygous for 1298. I have had no clots that i know of….i also never take my aspirin.

    One thing i suggest to anyone here worried about their blood clotting is Energy Therapy in the form of grounding or some other connection to negative ions from the Earth. Great strides have been made in the bridge between energy medicine and our worlds rigid rules in science. This book is worth the money: “Energy Medicine: The Scientific Basis” by James L. Oschman and Candace Pert.

    I look for alternatives to drugs because i’m too emotionally sensitive to chemicals. My anger and depression is too much for me.

    I found the connection between my nutzo attacks and folate recently when i read about the methylfolate side effects on this site (Thanks a bunch Dr. Lynch!) I was taking too much because the gene doc that found the mutation told me to take hand-fulls of folic acid. Then during the recent period of TTC i started the same outdated regimen. My sister said she found this site and tells me i need to be on less folate but a better kind and make sure i take it with p-5-p and methylcobalamin. I said ok, i will. Still under the same impression that i needed a bunch of folate, i disregarded the recommended dosage thinking i didn’t fall into the general population that the dose was recommended for and began taking at least 1mg per day. I frequently took 2mg.

    This didn’t really seem to be bad for me while pregnant. I was very relaxed and happy.

    After i had my son, my stomach calmed down and i began taking more of my favored suppliments including a high dose vit C. I only really ate once a day and it was a fairly big meal, so i took all my vitamins at once. This means my B12 was inactive and i was trapping my methylfolate and that made me more than a little crazy, depressed, and suicidal. I then had surgery and an infection, took some antibiotics that sucked and went clean crazy.

    One day recently i completely forgot to take b12, but took my 1mg of folate and B6. I went nutz. I tried to clean my house, but i couldn’t stay focused on one mess (manic) and i was yelling and crying (depressed) while trying to clean. My husband asked if i’d taken anything for my mood that day. It dawned on me that i wasn’t tolerating my supplements. He bought me some niacin, i stopped taking my folate, and i’ve been a happy, romantic angel since.

    Thank God. And definitely Dr. Lynch.

  66. Hazzell January 13, 2013 at 2:16 am # Reply

    Thanks for all this helpful info!

    I saw that you reccommend Betaine in the TMG form. I am having digestive difficulties and it seems I need to take a supplement to increase stomach acid. Does the TMG form help with digestion or do you reccomend TMG for other reasons? For increasing stomach acid, is taking Betaine HCL ok?

    (I have what I think is called compound heterogenous- one copy each of the two mutations C677T and A1298C)


  67. Penny January 20, 2013 at 7:55 pm # Reply

    I am wondering, when i was diagnosed recently my doctor said avoid Folate, which i understand better after reading your site! THankyou! Does that mean the natural sourxe also e.g.: green leafy veg?

    • Penny January 26, 2013 at 1:54 am # Reply

      Does anyone know if the leafy green veg folate is ok or not?

      • Dr Ben January 26, 2013 at 8:35 am # Reply

        Penny –

        Folate from leafy green veggies does provide some methylfolate – along with a bunch of other naturally-occurring folates. There are about 200 types of folate found in leafy green vegetables.

        Methylfolate is easily destroyed – so don’t cook it if you want to get your methylfolate from foods.

        • Penny January 26, 2013 at 8:56 pm # Reply

          THankyou, i was more concerned about it containing normal folate. So it is ok for me to eat then. I will. Thanks

  68. Tara January 23, 2013 at 6:21 am # Reply

    Hi Dr. Ben,

    My son is 5 and was diagnosed with Autism last year. He is heterozygous C677T and A1298C. His dr has him on daily B12 shots, 10mg 5MTHF per day, 10mg Folinic Acid per day and 1000mg NAC per day. He is also on 1200mg (Curcumin) for inflammation. His speech is improving, but he is very hyper and his behavior is getting bad. Is this too much?

    Thank you!

    • evy January 23, 2013 at 1:32 pm # Reply

      what form of b is he taking, cyano or methocobalmin?

      • Tara January 23, 2013 at 10:55 pm # Reply

        Hi Evy,

        He is taking methocobalmin.


        • evy January 24, 2013 at 2:20 am # Reply


          …he may be methylating much better, and then having too much of it happening (I am NOT an expert on all of this :). From what I understand one ought to slowly add one thing and then the next, to hopefully figure out what works best. My daughter, who is also hetero with the same two genes as your son (different health issues though) notices that sometime when she takes Dr. Lynch’s product homosystex on top of her 10 mg methylfolate that sometimes gets more aches or headaches or itchy feeling. But, she also says that often when she’s taking her 10 mg methylfolate and no homosystex and gets to feeling overstimulated/stressed that if she takes the homosystex it definitively improves her irritability/etc. in a noticeable way. So, it’s a day by day process, that is incredibly difficult to work with as how she feels is variable in a day, so if she feels better or worse, there’s no way of knowing why…too much b, or too much methylation or…. :) We keep trying!

          • Tara January 25, 2013 at 3:44 am #

            Thank you, Evy. I think you’re right. He has too much going on. I spoke with a new DAN dr today and he thinks there might need to be a new pathway opened or new methyl donors added. I’m also going to look into sulfur intolerance. I wish you and your girl the best! :)

    • Amee January 23, 2013 at 4:21 pm # Reply

      Hi Tara: I am sorry to hear about your son. I am no expert, I am homozygous C677T and all I can say is that the methylfolate makes my anxiety worse — heart race and insomnia. I was hoping it would help with my symptoms but I don’t take any at all. Maybe I am out of balance with other things but I think it is possible that methylfolate is not always helpful. I tried Niacin but got massive flushing with a small amount. Anyway, I am very interested to hear how Dr. Ben responds. Best wishes to you and your son.

      • evy January 26, 2013 at 3:40 pm # Reply

        Amee, how much methylfolate did you take and what other ingredients were in the capsules you were taking?


        • Amee January 27, 2013 at 10:16 pm # Reply

          Hi Evy, thanks for the note. My MD originally prescribed Deplin. I decided to start with Dr. Ben’s protocol and the Active B12 with Methylfolate and then Homocystex. I may have ramped up too quickly. I stopped taking it when I got up to doses close to the Deplin dose. I don’t remember the exact amount when I started the heart racing. However, now I feel like even when I try just one pill (800 mcg) some of my symptoms are worse (insomnia, anxiety), but that could just be coincidence I guess.

          • Dr Ben January 28, 2013 at 5:14 am #

            Amee –

            If you took the methylfolate close to the amount that Deplin provides, you definitely may have symptoms of heart racing, anxiety and insomnia. I rarely recommend people to take more than 4 mg of methylfolate daily. If they need more than that, then something else is wrong and must be identified and fixed.

            Remember to take some niacin – 50 mg every 30 min to an hour – in the event of methylfolate side effects.

            The Metabolic Maintenance methylfolate may be a racemic blend – meaning it has active and inactive forms of methylfolate. It is not about the other ingredients. The other ingredients in the Seeking Health methylfolate are very few, not flow agents or additives.

            If one takes a racemic blend of methylfolate, they may ‘feel fine’ because they are not utilizing the methylfolate as well due to the blend of active an inactive methylfolate.

            Read this article on the various forms of methylfolate.

            Also – some days you may need more methyfolate than others – so you have to keep tabs on how you are feeling. If you are feeling great, then that day you likely need to take less methylfolate.

          • Amee January 28, 2013 at 10:16 pm #

            Dear Dr. Ben: thank you so much. I have the insomnia and anxiety without taking methylfolate. The Deplin made them worse. I was afraid to try it again. However, I also have depression and my MD thinks the Deplin could help. I am not sure how that would work. He has just suggested I try a smaller dose. I guess I can do that. I tried Niacin but did not notice any improvement, only the flushing. Thanks.

      • Tara January 27, 2013 at 9:03 pm # Reply

        Hi Amee,

        Thank you for sharing your experience. It helps me to figure out how my son might be feeling. I’m sorry that the program isn’t working for you. Have you tried the B12 injections with 5MTHF? I notice that my son isn’t as hyperactive when he is doing the daily B12 shots. Everyone is so different. It’s hard to tell which program works the best sometimes. I wish you the best too and hope you find what works best for you. If you need to find a good Dr. who deals with this let me know. I know one in the Seattle area that my cousin goes to for MTHFR issues. Take care.


        • evy January 27, 2013 at 9:26 pm # Reply

          Tara, who is that doc?

          Thanks :)


          • Tara January 27, 2013 at 9:53 pm #

            Dr. Ikeda at Vital Family Medicine. She’s great! :)

        • Amee January 27, 2013 at 10:10 pm # Reply

          Hi Tara: Thank you for your nice note. No I have not tried any injections, but that is very helpful to know. I dont have an MD who does such things.I am in the other Washington (DC), and there don’t seem to be many progressive MDs around here. The only ones I found while searching have gotten negative reviews on the web. The MD who did the genetic test is a psychiatrist and he only prescribes psychiatric meds, which don’t work for me. But thank you for your encouragement! I appreciate it.

          • evy January 27, 2013 at 11:27 pm #


            I think because there are so MANY variables in the whole MTHFR stuff, it is extremely difficult to not only figure out, but also to treat. When the medications have other ingredients of ANY sort, that adds just more variables. My daughter (who is almost 20 years old) feels terrible when she’s on the Seeking Health Methylfolate (go figure!) but fine when she takes the Metabolic Maintenance brand of methylfolate. I would REALLY like to buy the methylfolate in bulk and make my own capsules, then I would know that was the only ingredient, or find some more affordable way to do all this. Needless to say, with as many sensitivities that MTHFR folks have at their disposal (laugh!) and with as many variables as there are in one day (or even one hour?) in how any number of their issues are doing at the moment, I can understand the difficulty in figuring out what med to take, which one made what result, and so on. Maybe at some point you might be able to re try just one treatment option, like methylfolate, at a very limited dose, and then working up and adding one thing at at time. That is something I have seen as a pretty consistent recommendation with the MTHFR :)

            And, I hope you find answers as you go along :)


          • Tara January 28, 2013 at 12:49 am #

            Hi Amee,

            Have you looked at Naturopath Doctors? Most Medical Doctors won’t treat you for what you need. If I had relied on MDs for my son we would be nowhere right now as they shut the door in my face right before I found a ND for my son. In my opinion Naturopath Doctors are the only primary doctor my son and I will ever have. Most are very knowledgeable about MTHFR. You might want to check out this website. They might be able to help you find a good ND in your area. :)


          • Amee January 28, 2013 at 3:48 am #

            Thanks Tara and Evy! You are both so kind to send these ideas to me. I really appreciate it. Evy – it is so fascinating to think that just buying a different brand might make a difference due to various ingredients. I will try it out! And Tara, Thanks for sending the link. I will look into it. I really appreciate both of you taking the time to write. Wishing your kids good health — it is nice that we can all try to help each other.

          • evy January 30, 2013 at 4:21 pm #

            Good to hear Dr. Lynch’s reply on this :)


  69. Rae February 10, 2013 at 8:51 pm # Reply

    Dr. Ben,

    I was recently began taking Metanx (thanks too your research and education). I am confused, though, about all the above recommendations. Do I need to take these if I am taking Metanx? Is there a simple method for keeping track of all the vitamins and minerals and supplements?

    Thank you.

  70. Lisa Marie February 16, 2013 at 4:26 pm # Reply

    Hi Dr. Ben, I have heterozygous MTHFR mutation C677T with a history of Lyme/Babesia (no longer active) and chemical sensitivity. Lingering health problems since a chemical exposure a few years ago. I’m seeing a great improvement in my health on a medically supervised ketogenic diet. I started adding in the MTHFR protocol about a month or so ago and have seen even more benefits since then. I have gone very slowly with adding supplements as I’m very sensitive. So far I’m on Pure B complex Plus 2 caps daily; sublingual methyl B12 1000 mcg; 500 mg magnesium orotate; 15 mg zinc orotate; 100 mg coenzyme Q10–as per deficiencies on spectracell testing. The only side effect from the diet is a dry mouth, which bothers me a lot. Started supplementing with egg yolk Lecithin and this helped tremendously with the dry mouth, BUT developed severe neuropathy after one day of supplementing three 600 mg caps. Extra B12 decreased the neuropathy and a day later was back to normal. My question is if phosphatidylcholine increases the need for additional folate and B12?

  71. Debbie G. February 20, 2013 at 3:56 pm # Reply

    I have read your protocol and website on MTHFR and was wondering if there is a protocol outline for compound heterozygous. I know you yourself are compound heterozygous like me so is there any differences in the protocol?
    Thank you Dr. Ben.

  72. Sharron March 8, 2013 at 12:54 am # Reply

    I was diagnosed this past September after having lost my first child in July as having MTHFR C677T heterozygously. I’m still trying to learn ways to take care of my self and be pro-active. I don’t have medical insurance so I can’t go to a doctor for any help or prescriptions. I read in your artical that people with MTHFR should stay away from antacids cause they diminish B-12 absorption. Problem is I have GERD really really bad. I have to take Prevacid daily or else I suffer immensely. How can I treat my GERD without affecting my MTHFR. Also are there ways to get methyfolate and B vitamins naturally without having to take pill such as eating certain foods? So far the only thing I’ve been able to do to try to take care of myself and prevent complications is I take a baby aspirin daily. I really would appreciate advice. Thank you.

  73. Kristen March 14, 2013 at 4:58 pm # Reply

    Dr. Lynch, thank you for offering guidance on MTHFR, I tested compound heterozygous positive for A1298C and C677T. We are planning a cycle of IVF with donor egg does this make any difference in the protocol? Our Dr. is recommending Lovenox inter-lipid injections through 12 weeks, I am wondering what your concerns are, if any with this drug? We have been looking at your protocol and have ordered your suggested supplements. I am currently taking a baby aspirin and 2250mg epa and 1000 mg dha, in addition to 2 multi’s, vit. D, NAC, GLA phosphotydlscyrine, DIM, vit. C, A natural thyroid for low thyroid, i am also prescribed iron but don’t know when to take it d/t interaction with other supplements. I eat organic foods, free range meets (I weigh 105 ibs and not sure how much protein). What is my protocol with vs without Lovenox. What is the optimal dose of activated b’s? I have been taking a b trio in the evenings for some time, after reading this I increased it to 1 3x daily, this was too much too fast for me, I felt very tired. I have since backed down to 1 at bed time, although my sleep seems to be affected. I will take the b12 separately once it gets here.

    I appreciate any guidance you can offer I am scared for my future health as well not being able to carry a child.

    Thank you.

  74. Liz March 20, 2013 at 2:39 pm # Reply

    Hi Dr Ben,

    I am very confused, I have tested positive for the heterozygous mthfr c677t one mutated copy, and my doctor recommended folic acid. From what you are saying I shouldn’t or should be taking it. Please clarify.

  75. Meg March 21, 2013 at 1:34 pm # Reply

    Hi Dr. Ben

    I read the above protocol, but what if you are compound heterozygous? I have both the C677T and A1298C. Also is being compound heterozygous more serious when it comes to pregnancy?

    Thank you so much!

  76. Larisa Lindemann March 21, 2013 at 3:33 pm # Reply

    I tested positive for both MTHFR gene mutations and am working with my MD who works in an integrative setting with naturopaths, etc. I am taking the Thorne Methyl Guard Plus 1 cap in the a.m. since 2 seemed to be too much creating agitation. I am 66 and have lived a healthy life and my parents/siblings are all healthy too. If i have both genes then they likely have one or both as well.

    I must say i am very curious as to why, if these gene mutations are so far reaching in terms of health complications, we don’t hear more about it in the media? Dr Andrew Weil has not addressed it and the Bastyr Univ web site has nothing on it about it either. I do find lots of complicated, technical research online that only confuses me. Why isn’t the medical /naturopathic community out there telling everyone to discuss this with their docs and look into getting tested??

  77. Tom March 29, 2013 at 4:27 am # Reply

    Dr Ben,

    I have traditionally had an extensive blood test every year for the last 15 years or so.
    During this time I have always noticed a recurring pattern: my vitamin B12 and folic acid levels are inordinately high. REALLY HIGH. I do take a number of nutrients, which include 400 mcg folic acid, and 1000 mcg of vit B12. Doctors always assumed that was the reason for my high levels. I had (have) developed an annoying skin condition known as Granuloma Annulare, which has unknown cause. During this time I had completely suspended taking any nutrients, as I thought something I was taking might be the cause. When I had my last blood test, my B12 and folic acid levels were still off the charts, even though I had not been taking any nutrients! That’s what brought me on a circuitous route to your site. Could it be that I am not methylating or utilizing these nutrients? I had called your office and set up to have my blood tested for the MTHFR mutation which I will do in short order.
    My Homocysteine level is 8.5 (range 5.0 – 12.0). I occasionally take high dose niacin for cholesterol and triglycerides (1000 mg). I do this only occasionally. This past year I am feeling much more fatigue than usual, am sleeping horribly, and developing some body aches. Honestly, this stuff is a bit daunting, as I assumed over the past two decades that dosing with a plethora of nutrients would be a good thing. Obviously, it isn’t necessarily so. The list is extensive: COQ10, NAC, Multi, Curcumin, Green tea, Boswella, Choline, Benfotiamine (B1), Pyradoximine (B6), Vit D, Omega 3s, Vit E (all tocopherols) etc, etc. I don’t smoke, drink about 1 glass of wine with dinner. I recently cut out eating wheat as gluten antibodies were detected though in small amount. I consume some dairy – half and half with coffee, and yogurt.

    Just want to feel better, and maybe it does have to do with MTHFR.

  78. Mark March 30, 2013 at 2:54 am # Reply


    Can I ask you if it’s necessary to take methylfolate if all you really need is methylB12?

    What I mean to say is that does the “folate” component of the methylfolate serve any purpose or is it just the “methyl” component that is needed to make methylB12 and lower homocysteine levels?

    Thank you

  79. Lisa Marie April 1, 2013 at 10:03 pm # Reply

    Hi Dr. Ben, I am heterozygous and started taking methylfolate and methylcobalamin along with a bunch of other supplements a few months ago. They have really helped my chronic health problems (Lyme disease, adrenal fatigue, hypothyroid). But my insomnia was still very severe. I followed your advice and avoided taking any B12 after 1 pm. Finally a couple weeks ago, I thought “well, my insomnia couldn’t get any worse anyway” and I started taking another dose of B12 with my dinnertime supplements. Wow! My insomnia has improved so much taking B12 late in the day. Taking a second dose of B12 earlier in the day had no effect, so the timing seems to be key. I just wanted to let you know as this is the first thing to help my insomnia, and I think your advice on this is wrong. Also, I feel much better taking two 1000 mcg doses of B12 than I did taking one.

    Thanks for the site!

  80. Danielle netherton April 7, 2013 at 4:00 pm # Reply

    what are your thoughts on Garden of Life raw prenatal? it seems thorn brand uses absorbic acid and it should be vit c

  81. BK Mom April 11, 2013 at 2:22 am # Reply

    What would be the recommended treatment for children? As a homozygote of C677T, I suppose each of my children are at least heterozygotes. My 5yo has serious anxiety, moodswings, and behaviors, and I was hoping this might help her. Thank you.

  82. Rohan April 18, 2013 at 1:17 pm # Reply

    Hi Doc,
    Ive been trying many things in a hope to find an answer to my fatigue and depressive tendencies. Ive been trying for years. Im almost at the end of a nutritional medicine degree which i started just so i can learn enough to heal myself. Well im so happy to have finally tracked it back to a hetero C667T mutation! I found out yesterday. I also have pyrrole disorder. I have been trying other nutrients for various reasons so im wondering if i should stop them all before starting Metafolin.
    I take 20mg Zinc, 500mg B5, 27mg P-5-P, 600mcg folinic acid, 200mg B2, and 200mg Manganese. I also use 200mg B6 occasionally.
    I would like to remain on the zinc and a B6 for the pyrrole, and will skip the folinic acid, but the others im not sure about.
    Thanks Ben

    • Amee April 19, 2013 at 2:10 am # Reply

      Dear Rohan: I will be interested to hear if Metafolin helps you. I hope it does. I have a homozygous mutation but the metafolin did not help my symptoms. Perhaps because I also have anxiety.

      • Rohan April 19, 2013 at 8:54 am # Reply

        How much were you taking Amee? and were you taking anything else?
        Have you found relief in any other ways?

        • Amee April 20, 2013 at 4:15 pm # Reply

          Dear Rohan: I have tried everything from 800 mcg/day up to Deplin levels. The higher I got, it actually made some of my symptoms worse (pulse, insomnia), and lower levels don’t seem to make any difference. Niacin did not help. However, I do not want to discourage you! I hope you find effective relief from your symptoms with folate. That would be wonderful! I have been trying different meds and alternative methods for many years, I am over 50, but I have found anything yet to really help and pass on to you. Lately I think it may have an environmental component. Anyway, I have not yet given up hope and will keep trying and report here if I find anything helpful.

          • Rohan April 20, 2013 at 11:32 pm #

            That’s disheartening Amme. Keep searching! Have you thought about checking out the functionality of COMT, BH4 or MOA?

  83. Steve Thompson June 2, 2013 at 5:31 am # Reply

    Dr Lynch.

    I have tested homozygous A1298C.

    Have you had a chance to develop a protocol for 1298C please?

    Thanks, Steve.

  84. Jennifer June 4, 2013 at 11:54 pm # Reply

    Hi Dr. Ben, I was recently diagnosed with Homozygous C677T. I will be starting IVF #2 later this month, and have been reading your site, trying to learn as much as I can about the MTHFR mutation. My RE and Acupuncturist seem to have different viewpoints on the mutation, and have prescribed different things (RE prescribed 4mg Folic Acid daily, Acupunturist prescribed 2400mcg – 3200 mcg Metagenics ActiFolate daily).

    I had a chemical pregnancy with IVF #1 nearly 2 years ago, and since then I have been on a protocol of the following supplements: CoQ10, Fish Oil, Calcium Magnesium, Magnesium Glycinate, Royal Jelly, Metagenics Prenatal. I saw you recommended Tumeric, but my Acupuncturist expressed concern that I should only take it before ovulation, because it causes such an increase in circulation. I’ve read that Pygnogenol can be good to take because it reduces inflammation, but I have been hesitant to add one more thing to the mix.

    For the past 1.5 years I’ve been eating a dairy-free diet rich in organic eggs (my Acupuncturist said eggs don’t count as dairy?), antibiotic-free meat, vegetables, and taking green food supplements, with little to no processed foods. I’ve also been gluten free for the past three months.

    Anyhow, I’m hoping all goes well with IVF#2. While I’m trying not to be overly concerned about my MTHFR news, I want to be as informed as possible. I am concerned as to the different opinions held by my RE and Acupuncturist, and wondering which is best for me to take — Folic Acid or Folate? Based on what I’ve read on your website, it looks like Folate is the way to go. During my second week of taking high dose Folate, I began to experience anxiety and difficulty sleeping, so for the past few days I have taken the Folic Acid instead of Folate. I’m planning to do as you suggest, start with 1 Folate / day, and work up.

    Also, my RE is not planning to put me on Lovenox or Baby Aspirin during my IVF, but I’ve read that it is common for women with Homozygous C677t to be on a regiment of Lovenox and Baby Aspirin before, and throughout, a pregnancy. My RE says he doesn’t believe MTHFR was the reason for my chemical pregnancy, and believes that Lovenox comes with its own risks. My concern is that during IVF #1, in the few weeks I was pregnant, and before I knew anything was wrong, I felt strongly like my body was fighting something. I know it’s a mystery as to whether my body would be fighting because it was a bad embryo, or whether my system was just fighting a pregnancy in general. Unfortunately, we’ve also dealt with Male Factor Infertility, so I have not been able to see how my body reacts to a natural pregnancy. Anyhow, I’m wondering if you have an opinion on when Lovenox / Baby Aspirin should be used in conjunction with IVF.

    I’ve learned that my Homocystein Level is 5, and my Folate and Vitamin B levels are within normal range. I also have some blood clotting issues, where tests indicate that I have mild Hemophelia (although I’ve never experienced clotting difficulties with day to day cuts and bruises, etc.).

    Thanks for much for your website, and for your input. Much appreciated!

  85. Liz June 14, 2013 at 1:30 am # Reply

    I’m doing better on the Active B12 lozenge, but didn’t do well trying the other ones. So I’m ready to add the extra B12 you recommend. I read somewhere that B12 repletion uses up your potassium. I take 99mg potassium citrate each day. Do you think your protocol should include taking extra potassium after you begin adding additional B12?


    • Dr Ben June 14, 2013 at 4:16 pm # Reply

      Hi Liz –

      Yes – I do. I believe it should also include extra magnesium as well. Magnesium deficiency increases potassium deficiency. It may actually be the increased utilization of magnesium causing the potassium deficiency. The potassium deficiency may be secondary to the magnesium deficiency.

      • Liz June 15, 2013 at 2:32 am # Reply

        Thanks so much for responding! I take 175-250 of mag citrate everyday already. So am I understanding that I need MORE of that as well as MORE than 99mg of potassium when I add the additional B12 or am I good to go?

        By the way, I finally got my doc to order a B12 deficiency test because she just kept wanting to give me FolaPro and I was feeling so much worse on it. Now that I take your lozenges (and Optimal Turmeric) I’m feeling better and the neurological symptoms (balance, and difficulty walking) are starting to subside after onset 3 months ago. It got pretty scary, but I think I’m on the right road and feel that I do need to up the B12 as safely and quickly as possibly because the SMMA test did show quite a deficiency.

        Do you have a product that you recommend for supplementing the magnesium and potassium as one increases the B12 or will the current mag citrate dose and potassium at 99 mg suffice as I continue to increase?

        Thanks for all you do for us who suffer so horribly with this. I credit being raised on a small organic farm and continuing that lifestyle into adulthood, along with no smoking, recreational drugs, and alcohol, for keeping me from having a total health meltdown until now at age 56. I’m homozygous C677T. I think your website has saved my life, literally, as my doctor was so off base with her 3200 mcg per day FolaPro approach and my neurological symptoms were getting worse by the day. But thankfully she is willing to trust my research and consider your protocols and products.

        I’m “dancing” with you and hoping to keep the movement growing. ;-)

  86. RoJoCo June 18, 2013 at 4:09 pm # Reply

    I’m homo 677T (also homo for VDR Taq, MAO A R297R, MTRR A66G, BHMT-08. I’m hetero for COMT V158M, COMT H62H, MTRR A664A, BHMT-02, BHMT-04). When I look at your recommendations for part 2, I see “Once you have determined you respond well to the probiotics, krill oil, turmeric and vitamin E, then you may proceed to slowly adding the following.” It doesn’t mention the multi. Should we continue taking that as well? I’m just getting started and will start with the multi but I’m a big picture type of person and trying to understand! :) I should note that I was taking Thorne B #5 and if I take two days in a row, I get headaches. I usually don’t have issues with supplements or multis in general, though – first time. Additional question: my husband has a JAK2 mutation. Doc just says to take an aspirin. Would Flow FX be a good alternative? (He doesn’t take aspirin now as he has concerns about stomach damage.)

  87. Josh June 21, 2013 at 6:45 am # Reply

    I’m heterozygous for both 677 AND 1289.

    I have Asperger’s, pretty bad depression, an anxiety disorder, immune dysfunction, a skin condition, and digestive trouble.

    I was taking methylfolate by itself for a while (FolaPro), but yesterday I began taking Country Life Coenzyme B-Complex Caps (which includes 800 mcg methylfolate and 500 mcg methylcobalamin).

    How might this 677 protocol for someone with an additional heterozygous mutation be changed?


  88. Jen June 21, 2013 at 3:49 pm # Reply

    Hi Dr. Ben, I just received the news that I have a homozygous MTHFR defect…I believe mine is the 677 varient since it was associated with slightly high homocystine levels. This was discovered through genetic testing after my third recurrent miscarriage. Because prenatal vitamins have high levels of folic acid…which it would seem that I am deficient in processing, do you recommend not taking pre natals but rather taking the methylfolate 1000mcg? And can I take some sort of multi-vitamin to support pregnancy? I have had a successful pregnancy previously so am not sure if this means that I am able to process some folic acid or not? Also, I am unclear about whether it is a good idea to eat folic rich foods like spinach, or am I supposed to try and limit these foods? Thank you so much

  89. Deanna Nottingham June 28, 2013 at 1:52 am # Reply

    Dr. Ben,
    I have been doing some of my own research before going to a Rheumatologist (who I was referred to after several blood tests showing a positive ANA Titer 1:320, a high rheumatoid factor, and low vitamin D). I was also diagnosed with C677T MTHFR homozygous twelve years ago. At the time I had two miscarriages at 14-16 weeks along so luckily I found a Hematologist who had some knowledge about MTFHR at that time. Obviously so much more research has been done. I was treated with heparin and baby aspirin and carried to 38 weeks (when I was induced) with two children; the first in 2002 and the second in 2005. So that was successful and I had no other problems per say nor has my Doctor ever suggested any further treatment for my MTFHR.
    So, to bring you to date; for several years I have had fatigue, headaches, and just all around feeling achy and foggy headed on a regular basis. Twelve years ago almost everything I found on MTFHR was about pregnancy, so as time went on I never considered that many of my symptoms could be related. I have however mentioned that I have MTFHR to every Doctor I have ever seen. Recently after a couple of weeks of debilitating pain, I decided to have blood work done to see if I have an autoimmune disease. I have now been referred to a rheumatologist with a diagnosis of “unspecific autoimmune” and my doctor wants me to start taking Cymbalta. After reading your article, I am wondering if the above mentioned blood tests could be related to my MTFHR or is it something entirely separate. Do I even need to see a Rheumatologist at this point or should I try the supplements first? What are your feelings on the Cymbalta? I have not started taking it yet but I have had the prescription filled. I am hoping to have as much research done as possible before going to see the Rheumatologist.
    I look forward to your response. Thank you so much for your time.


  90. Merle July 4, 2013 at 4:12 pm # Reply

    I am so confused and overwhelmed. I’m 39 and have always been healthy – eat healthy, exercise, don’t get sick etc. until, following two miscarriages, I just found out that I have the MTHFR mutation – I think hetero C and A. My RE (a very good one in CO) prescribed Folgard, but I don’t meet with him for a week.

    I have NO IDEA what to do. I’ve always subscribed to a more holistic way of living (organic, free range et al), I avoid toxins, and processed foods.

    Guidance, please!

  91. Karri July 10, 2013 at 2:26 pm # Reply

    I just got diagnosed as being homozygous for the C677T mutation. My doctor prescribed Cerefolin NAC. I saw in your recommendations that this medication is not necessarily good for this condition. How so? Thanks.

  92. Adreanne July 15, 2013 at 4:13 pm # Reply

    I need some advice, my daughter is living on 6 foods and nutritionally starving, I want to start supplementing but your muliti’s are full of Fructose Malabsorption issues, she has sensory issues, behavior issues, Fructose Malabsorption, yeast issues, sleep issues, gi issues, you name it. Do you have a protocol that would list individual or multiple vitamins you recommend that are not sweetened, made from fruits/veggies etc? we hope that with treatment those issues will improve but the treatments will be so horrific for her tiny self (19 mos 30lbs) that I cannot use the “ends justify means” theory! Do you think you can help? since you no longer take consults I am just praying you have time for some advice!! Thank you for this website and such great information at my fingertips, we are just a special case of what do we do now!

  93. Noelle July 22, 2013 at 10:33 pm # Reply

    My son is heterozygous for C677t and A1298C. I am confused if folate will help or cause more problems. just a brief history- He has had reflux for many years. An upper GI showed eosinophils count of 78 in his esophagus, and some fissures and swelling. His GI doctor believes he has eosinophilic esophagitis gastroenteritis. However I have learned that my son needs to be on a PPI for 6 weeks with no relief from reflux before it can be considered EGID. Obviously I am not to thrilled about putting him on a PPI for that long.

    So I have often wondered if this gene mutation could be a cause of some of his problems and wanted to try to supplement it. It appears from what I have read, that I should give him a folate supplement for C677 but be careful with the folate for A1298C. ????
    Any advice would be greatly appreciated.
    PS- I am kicking myself for not scheduling an appointment with you last year when I first start buying your supplements and reading about all this!!!!

  94. Darla July 27, 2013 at 9:21 am # Reply

    I have been told I have this mutation. I also suffer from recurrent Cushing’s Disease due to ACTH pituitary MACROadenomas, I’m also dealing with chronic pain, among a ton of other weird medical problems. I’m curious to know if there is any known correlation between this gene mutation and Cushing’s Disease specifically, or hormone secreting pituitary tumors? Where can I find a list or article on known risk factors involved in having this mutation? How important is it to go back and find out the specifics on the mutation that I have? All I was told was that I have a gene mutation MTHFR and that while I was pregnant (and recommended life-long) that I should be on low-dose adult aspirin. How can knowing the specifics help me? Are most doctors familiar with implications of having this gene mutation?

  95. Angie July 27, 2013 at 5:53 pm # Reply

    So I was just diagnosed with homozygous cz77t and 2 copies of mutation. I had 3 miscarriages and finally adopted. I had seizures when they treated me for tubal pregnancy with methatexate and at dentist when getting novocaine had another seizure not sure why but none since. My legs have ached on and off through out my life and I have felt depressed much ofit but fought it with exercise. My doc just put me on one pill daily of 5mthf with a b complex #6 taken with food. What do u think?

  96. Polly Maclan July 29, 2013 at 4:56 pm # Reply

    Dr. Lynch,

    I am grateful to have found your website and am trying to develop an appropriate protocol for trying to conceive and sustain a healthy pregnancy. I have been diagnosed with multiple sclerosis, P.C.O.S., as well as heterozygote 4G/5G polymorphism in the PAI-1 gene and homozygous C677T mutation in the MTHFR gene. I struggled with calcium oxalate kidney stones and candida overgrowth for extended periods and have in the last couple of years been free of these issues, which after reviewing this site, I now believe were related to MTHFR.

    I conceived 6 years ago and miscarried around 5 weeks, after which the PAI-1 and C677T information was discovered. The report from the maternal fetal medicine physician states that the remainder of the testing panel proved normal which included (at least) the anticardiolipin antibody testing and the lupus anticoagulant due to family autoimmune history.

    I have been advised to take 4 mg folic acid and 81 mg baby aspirin daily, which I had been doing for a number of years. After reviewing the C677T protocol on this website recently, I am in the process of transitioning to methylfolate (currently Solgar) and methylcobalamin (currently Jarrow Formulas 1 mg and Optimal Multivitamin with Iron) but am planning to switch to Optimal B vitamin products once I have worked my way up in dosage. Prior to this I had also been supplementing with and plan to continue supplementing with the following: baby aspirin, daily probiotic, D3, fish oil, calcium, magnesium and P5P. I have ordered the Seeking Health Probiota 12 and CoQ10 and should receive them this week.

    Additionally, I have been gluten free since November and on a low oxalate diet for several years due to the kidney stone/candida issues. I practice yoga 4 or more times a week and have found that to be beneficial in the healing process. With these changes, I am feeling better than I have ever felt and believe that the changes in B vitamin administration will only enhance the healing process. Even with the P.C.O.S. diagnosis, I have started ovulating on my own since beginning the magnesium supplement and now appear to have a normal cycle as long as I am on the magnesium.

    Are there any supplements that you would recommend in addition to those listed above that would aid in establishing a healthy environment in which to try to conceive? Are any of the supplements above (or any additional recommendations) unsafe for pregnancy? I am wondering if you would recommend that I obtain a heparin or lovenox prescription as well in light of the PAI-1 polymorphism?

    I find your comments regarding establishing a healthy balanced environment for conception and pregnancy maintenance to be very encouraging and any guidance you can provide will be much appreciated. To date, my infertility diagnosis as been “unexplained”, but as I learn more and have begun making changes many of which are advocated on your website, I become healthier and healthier. This seems like a much better position for trying to conceive, and I would welcome any additional insight you can provide.


  97. Kimberly August 1, 2013 at 11:35 am # Reply

    Are there alternatives for methotrexate and immunosuppressant drugs for those with MTHFR defect?

    I am heterozygous C677T. My brother, who has since childhood struggled with wellness, is now in end-stage nonalcoholic liver failure (also spleen failure and uncontrollable diabetes). He has been in the wait list for a liver transplant since Feb. 2012.

    I have a neurological tumor that may be an autoimmune process rather than cancer; the treatment for which is methotrexate, steroids and immunosuppressants.

    How do the standard immunosuppressant and transplant meds we will need to take affect those with MTHFR? Are there MTHFR-friendly alternatives? Or, is there a prophylactic therapy we should implement to offset the toxicity if we take these meds?

    He does not want to get the test through his insurance. Is there a private test company that tests for both testable genes? (I believe the test through 23andme is only for C677T).

    Thank you!

  98. Alison August 4, 2013 at 9:42 pm # Reply

    Do you have a starter protocol for compound heterozygous?? And modifications to that for children? Thanks!

    • Dr Lynch August 5, 2013 at 7:21 pm # Reply

      Hi Alison –

      Compound heterozygous is relevant to this post as well.

      Modifications for children must be done with your doctor – and of course so are the above suggestions.

      Single and/or double MTHFR A1298C mutations are not relevant to the recommendations for nutrients – but the points about lifestyle and dietary changes are still relevant – for most people if not all.

      • Karen Clow August 8, 2013 at 6:42 pm # Reply

        I’ve been told by 2 Md. that I have no to be concerned about compound heterozygous The latest one saying that one factor is working while the other is not. I would appreciate your opinion. Thank you

  99. Joy August 8, 2013 at 1:44 pm # Reply

    What is the supplement protocol for A1298C mutation? I am homozygous for A1298C and also heteroz. for Prothrombin II gene mutation. My gyn/family dr put me on FolaPro (L-5-MethylTetrahydrofolate) and a baby aspirin. Also recommended Curcumin and Magnesium. My 1 yr old baby daughter is heteroz. for C677T – is there anything that I should be doing for her supplement or food wise? I have a 12 yr old son that is ADHD, has not been tested for mthfr but will be this month. I also forgot to mention on my survey that I am always cold – not to an extreme but I am uncomfortable in cold restaurants and at home when others are comfortable. My moods are also all over the place. Could this be related to mthfr?

    • Joy August 8, 2013 at 1:50 pm # Reply

      Also, we try to eat healthy. Organic, no artificial colors and flavorings. Have been trying to cut wheat out of diet as well. Are there other diet modifications that are helpful and if so why?

  100. Aaron August 10, 2013 at 3:02 pm # Reply

    Hello Dr. Ben,

    I live in Thailand doing humanitarian work and my father was recently tested and found to be homozygous and then my sister was tested and found to be heterozygous. I expect that I am also at least heterozygous though I have not been tested. I am now trying to figure out how to manage a condition am pretty sure I have on an extremely limited budget and outside of “the West.” Do you have any recommendations for me?

    Thank you,


  101. Holly August 24, 2013 at 5:13 am # Reply

    My mother who is 56 was diagnosed with central retinal vein occlusion in March she is being treated with injections in her eye. Her eye doctor suggested she get her homocysteine levels checked they were 30.2, they have since risen to 36.2. She was sent to a hematologist after this where they checked her for MTHFR, and Factor II. She tested normal for Factor II but discovered she has one copy of the Heterozygous c677t mutation. She also was recently diagnosed with gallstones

    My sister who is a type 1 diabetic (32 yrs), brother (16 yrs) and myself (19 yrs) have since been tested for MTHFR. My brother is normal, but my sister and I both have the same mutation as our mom but with normal homocysteine levels. I know my sister and I should be safe just taking your multivitamin but what should my mother take in order to lower her homocysteine levels into a safe level? Also is there any other testing we should have done? Thanks so much!

    • Lynn_M August 25, 2013 at 9:14 pm # Reply


      In regards to your mother’s central retinal vein occlusion, you might be interested in this article:

      The first paragraph is: Central retinal vein occlusion (CRVO) in the young is also known as papillophlebitis and is a rare presentation.1 Retinal vein occlusion has been known to be associated with many systemic conditions.1,2 Association of hyperhomocysteinemia with retinal vein occlusion was reported in the literature.2-4 There was controversy, however, over whether there was correlation between methylenetetrahydrofolate reductase (MTHFR) gene mutations and hyperhomocysteinemia with the CRVO.5-8 We report a case of young female with unilateral papillophlebitis who was found to have positive homozygous mutations for MTHFR C677T and A1298C genes, which are suggestive of hyperhomocysteinemia.

  102. Amee August 26, 2013 at 8:15 pm # Reply

    I have the homozygous C677T Mutation. I also have as symptoms depression, anxiety, fatigue, muscle weakness, and chronic insomnia. Folate supplementation has not helped, and high doses (deplin) made me feel worse –niacin did not help. My serum folate and B-12 levels in bloodwork were normal and even on the high end for folate. I have some anemia results with high MCV and MCH and low ferritin and RBC. My homocysteine is very low. I have tried all kinds of supplements and meds for years with no relief. I recently read that recommendations for low homocysteine include methionine, N-Acetylcysteine, taurine and lipoic acid. Are there any risks to taking these with MTHFR mutation, even though I have high folate and low homocysteine on blood tests? I thought I would at least try them. My MD has also prescribed ferrous sulfate. It hasn’t helped me feel better yet. My symptoms are worst during PMS, if that means anything.

    Thanks for any input.

  103. Heather L. August 26, 2013 at 11:14 pm # Reply

    Dr. Ben,

    I have had 2 miscarriages. The first one in April 2011 and the second one May 2013. After the second miscarriage my doctor had bloodwork done to determine cause. This is what was found:
    PAI-1 4G/5G – heterozygous for the 4g/5g deletion/insertion allele.
    two copies of the same mutation C677T for MTHFR
    Single R506Q mutation (heterozygote) for Factor V Leiden

    My doctor has told me to take 1 baby aspirin everyday, my prenatal vitamin everyday, and 3 folic acid pills everyday. Is this something I should be doing? Wanting a second opinion. I do have a history of heart disease in my family. My dad has had stents put in and my mom just had 3 put in. I would really like to have another child but am not sure if I should consider it after finding this out. All these terms are foreign to me. Please help!

    • Heather September 5, 2013 at 6:51 pm # Reply

      Dr. Ben, do you have any advice to my above post?

  104. joni schneekloth September 4, 2013 at 6:13 pm # Reply

    I have active lyme cd 57 lab was 18 and heterozygous c677t and does these gene mutation effect my ability to overcome lyme

  105. Kara September 5, 2013 at 4:21 pm # Reply

    Hi Dr. Ben,
    I am a 34 year old mother of one healthy 3 year old child. My husband and I have been trying to conceive for the last two years, and I am currently experiencing my fifth miscarriage (all in the 5-8 week range). The only thing that shows on tests for me is Heterozygous C677T. My husband is clear.

    My OB has wanted me to use Lovanox, but I feel this isn’t the answer (or the only answer). I read about women with Heterozygous MTHFR that use this and still miscarry, even late term. This terrifies me.

    I am going to be trying your Basic MTHFR Protocol starting this month. Question – can I also get B vitamins through my diet (I eat liver, grass-fed) or would this be too much Vit B on top of the supplements? I don’t want to overdo it, but I’ve read that eating liver can be a great source of naturally occurring B Vitamins. It is hard to find a reliable source that can give me an answer on this.

    Thank you so much for this website, it has been a light in a dark time for me.

    Thank you,


    • Dr Lynch September 5, 2013 at 6:23 pm # Reply

      Hi Kara –

      Liver is a great source of a few B vitamins and iron.

      Issue is many of the B vitamins may be destroyed by cooking.

      It is hard to say which B vitamins you will get and the amounts.

      The good thing is B vitamins are water soluble so you will simply pee them out. The toxicity of B vitamins is very low. B6 can be an issue if taken too much.

      Eating well and taking additional supplementation is likely needed. I highly recommend a more comprehensive test like 23andMe and then running the MTHFR Support report. Why? Because they show additional genes which may be affecting your pregnancies. Of course, other things may be a factor also outside of genes.

      Monitor lab work with your physician is the best advice I can give.

      • Joy September 6, 2013 at 12:24 pm # Reply

        Dr. Ben – Help! What is the proper supplement protocol for A1298C mutation? I am homozygous for A1298C and also heteroz. for Prothrombin II gene mutation. My gyn/family dr put me on FolaPro (L-5-MethylTetrahydrofolate) and a baby aspirin, but has recently switched me to Metabolic Maintenance B-Complex with 800mcg 6S 5-Methylfolate. Also recommended Curcumin and Magnesium. My hormones are crazy so I’m also on compounded progesterone and prenenalone, and DHEA. On my bloodwork I also had antinuclear antibodies come back in a speckled pattern so my dr is sending me to a rheumatologist. (My MTHFR was discovered when I was trying to get pregnant at age 40, after a miscarriage, by a neurologist who also does traditional chinese medicine & acupuncture. Took lovenox throughout pregnancy and had a healthy baby girl, but low birth rate due to placenta issues.)

        My 1 yr old baby daughter is heteroz. for C677T – they didn’t run the A1298 test so we went back for that bloodwork and are waiting for the results – is there anything that I should be doing for her supplement or food wise? I have a 12 yr old son that is ADHD, has recently been tested for mthfr and we are waiting for the results. We are trying to switch to a gluten-free diet.

        • Joy September 12, 2013 at 3:10 pm # Reply

          As a follow-up, after doing the proper tests, my baby girl (14 months) is heterozygous for both C677T and A1298C, as is my 12-yr-old son (also ADHD). What type of protocol is recommended for kids with compound mutation? Should I be supplementing the 14 month old? As for me, I am experiencing a lot of leg pain, and overall achey. Could this be from the new B complex/methylfolate I’m taking? I started other things (DHEA, pregnenalone) at the same time so I’m not sure. And I was a bit achey before but it seems to be worse. My antinuclear antibodies came back with a speckled pattern so I am also being referred to a rheumatologist. And insight you can provide would be helpful.

  106. Camilla September 12, 2013 at 1:32 pm # Reply

    Dear Dr Ben,
    I was recently diagnosed with MTHFR 2 mutation A1298C and C677T homozygous. My PCP prescribed a baby aspirin and Metanx. I have in the meantime switched to Seeking Health Active B12. It appears I can only tolerate 1/4 pill of the Active B12 every other day without getting incredibly irritated and feeling down. Is that a sign that more would be over-methylation?
    Also, I heard that Vit B6 is very important but is not something I am currently supplementing.
    After having dealt with Candida last year I am on a healthy diet, 99% gluten and dairy-free, lots of vegetables, krill oil, evening primrose oil, multi-mineral, D3/K2, Chlorella.
    I also take Red Yeast Rice and CoQ10 for high cholesterol.
    The information on MTHFR is so confusing and it also seems to affect doctors. My mother was diagnosed with MTH 1 C677T and A1298C heterozygous. Her doctor told her she is only a carrier which doesn’t seem right to me.
    Any feedback would be much appreciated.
    Thanks, Camilla

  107. Roxanne Leonard September 16, 2013 at 5:13 am # Reply

    daughter is taking 50mg of zoloft due to PTSD.. coud she cut back on zoloft now that she is on the methylfolate? She is showing signs of anxiety and combativeness …much more talkative (good thing as she has speech apraxia) and I don’t know if these are from the 3/4 tablet daily or from to much zoloft????

  108. Mark September 16, 2013 at 4:55 pm # Reply

    You mention that if you tolerate the Active B12 with Methylfolate lozenge, then you should switch to homocysteX and then to homocysteX plus. It appears that the homocysteX formulations are capsules and not lozenges. Wouldn’t the absorption of the methylcobalamine and methylfolate be greatly reduced in these formulations?

  109. Melissa September 17, 2013 at 6:33 pm # Reply

    Hi Dr. Ben,

    I am homozygous for the following:

    COMT V158M
    COMT H62H
    MTR A2756G

    hetero for:

    COMT P199P
    VDR Bsm
    VDR Taq
    MTRR A66G
    CBS C699T

    I currently take intramuscular injections of methyl b-12, Folinic Acid and B-complex, which overall make me feel much better.

    My b-12 is <2000 which i imagine is high. I had it read yesterday. I've been reading conflicting information, that if i have other mutations (comt etc) that i may require a different form of B-12.


    All Best,

    • Melissa September 17, 2013 at 6:34 pm # Reply

      And i forgot to mention homozygous for MTHFR C677T!

  110. Nicole September 20, 2013 at 7:41 am # Reply

    Dr Ben,
    my whole family have just found out that mutations run right through. my daughter is homozygous C677T, other tests are pending but we have many tongue ties, clots and miscarriages so we sort of know who has what already. I wish to share your recommendations with my family but most of them are not at all into natural medicine or alternative health, and will seriously balk at most of it, thinking it is just quackery if it hasn’t come with strong research backing and/or mainstream medical support. Are you able to do another article with your recommendations (perhaps also shortened a bit might help) with links to research supporting each recommendation OR at least an explanation for each? (some of the earlier ones have reasoning which is great, but the ones like eliminate wheat and plastic food containers have none. While I understand these, my family will not, and would never believe me.)
    Thanks so much,

  111. Ann October 1, 2013 at 4:37 am # Reply

    Dr you are a god-send!!! Thank you, thank you, thank you!

    I am an age 51 menopausal female with the following data points and would appreciate your recommendation on protocol.

    Current medicines
    1. Compounded BHRT Progesterone cream 200 ml/day
    2. Compounded BHRT Estradiol cream 1.5 ml/day
    3. Compounded Armour Thyroid 15 mg / day (optimizing currently / started in August 2013)

    1. Severe debilitating brain fog / cognition decline
    2. Eye sight declining rapidly
    3. Pain in knees (started when taking

    Bio Marker Blood Serum 08/24/13 – abnormal results only
    1. TPO 212
    2. Antithyroglobulin Ab Throglobulin Antibody 3.7
    3. Lipids
    a. Total Cholesterol 197 (down from 242 in Feb 2013)
    b. LDL-C Direct mg/dl 131 (down from 156 Feb 2013)
    c. Non-HDL-C mg/dl 139
    4. Lipoprotein
    a. Apo B mg/dl 102
    b. LDL-p nmol/L 1455
    c. sdLDL-C mg/dl 28
    d. Apo A-I mg/dL 131
    e. HDL-P umol/L 29.7
    f. Apo B: Apo A-I Ratio .78
    5. Inflammation/Oxidation
    a. Fibrinogen mg/dl 466
    6. Platelet Genetics
    a. CYP2C19*2*3 *1*2
    b. CYP2C19*17 *1/*17
    7. Coagulation Genetics
    a. MTHFR C677T C/T Heterozygous (A1298C A/A normal)
    8. Metabolic
    a. Homocysteine umol/L normal 8
    9. Omega 3 index (epa + dha) low 4.3 (target 8)

    1. what protocol do you suggest for optimal management of the above?
    2. what protocol do you suggest for minimum management of the above, due to financial constraints?
    3. any other lab tests you recommend (vit deficiency, etc)?

    I will standby for your comments. Thanks in advance!!!!!

  112. Debbie October 1, 2013 at 2:10 pm # Reply

    Dr. Ben,
    Having severe allergies and heavy metal poisoning my doctor discoveredI have two of the genetic MTHFR defects. She put me on Methylguard Plus, one capsule a day. After 2 weeks I started having boating, belching, fullness and nausea in my stomach. She told me to continue taking it. I stopped after 6 weeks as now my liver enzymes are very high and I am in intense abdominal pain mostly on the right. Now I have to see a Gastroenterologist. Could these problems have been caused from the methylguard, and if so do you have any suggestions in relieving symptoms? Thank you, Debbie

    • Steve Thompson October 2, 2013 at 12:28 am # Reply

      Hi Debbie.

      The one-size-fits-all approach definitely does not fit all.

      My doctor also started me on Methyl-Guard Plus after finding my mthfr defect, but I started feeling worse from day one. After three days I stopped. Over the last four months I’ve tried just a half a capsule a couple of times a week, and then down to a quarter of a capsule, but still feeling much worse. Then I bought the individual components and added each one individually, at the same dose as in the Methyl-Guard Plus. All ok until I added the methyl-folate (B9).

      I’m going to guess that your mthfr gene is the A1298C variant, not the C677T variant? If so, that one seems to process folate to methyl-folate almost at full rate, meaning that if you supplement high doses of methyl-folate you may be getting too much. It’s not toxic but it drives other processes too hard. My Red Blood Cell Folate has always been high, even before I started supplements.

      People with the C677T variant need more folate in their supplements and/or diet because that variant doesn’t process folate to methyl-folate very efficiently.

      Methyl-Guard Plus has rather high doses of folate (B9) and B6, which it seems people with A1298C can’t handle. It also has a big dose of TMG (Betaine), which drives the short route converting homocysteine to methionine. That drives higher levels of SAM-e which can also be troublesome for some people.

      I’ve now dropped this doctor and I’m currently taking Thorne Multivitamins for Men Over 40, which has much better ratios of vitamins, but still includes the active forms of the B vitamins. Thorne has versions of that multivitamin for children, younger women and older women, which may wife and two daughters are now taking. I’ve also ordered the Amy Yasko All-In-One multivitamin which is very similar but has a lower dose of folate. I’m also taking extra B12 in a few different forms. Only been a few days but the symptoms which had been worsening under that doctor’s protocol are beginning to lessen.

      Which MTHFR variant do you have?
      Have you had any other DNA tests, such as from or the Amy Yasko Methylation Analyisis?
      Has your doctor tested any of your biochemistry, like homocysteine and Red Blood Cell Folate levels?

      Steve Thompson

      • Debbie February 6, 2014 at 10:14 pm # Reply

        Hi Steve,

        I wrote back in October. Its been a while but I have been really ill. I have two copies of the same mutation (A1298C/A1298C) identified. Results for the C677T mutation were negative. Elevated homocysteine levels have not been reported when two copies of the A1298C mutation have been found. I am totally confused as what I should be taking. One of the biggest issues I have is an allergy to binding materials in pills or agents in capsules. I’m between a rock and a hard place here. Ever since they took out my thyroid I have not been able to get back on my feet. Do you have any suggestions?


  113. Katie October 5, 2013 at 3:03 pm # Reply

    hi, I recently was tested positive for a heterozygous mutation and am very overwhelmed. I have had a variety of health issues over the past few years and feel like this is related. My doctor put me on metanx and told me to take methyl B12 (5000mg). I also have added in NAC (600mg), B2 (100mg), TMG (500 mg), Vit E (400IU), Zinc, cod liver oil, and probiotics. I would like to start of your protocol, but have paid for 6 months of metanx and want to finish that before switching. Can you help me to figure out if there are additional supplements that I need to add in, or if I am taking too much of something? I am feeling a little better, but still know that there is much room for improvement with anxiety, energy, neck strain, ect. Thank you so much for your help. It really is an overwhelming process, especially when you cant find a doctor to help guide you!

  114. DottyJ October 15, 2013 at 4:10 am # Reply

    You recommend limiting the intake of high methionine containing foods, and have provided a link which has a long list of processed and unprocessed foods.

    What would you recommend as the daily intake of methionine where homocysteine is elevated.


    • Dr Lynch October 15, 2013 at 5:36 am # Reply

      Hi Dotty – I recommend limiting high intake of methionine when one has high homocysteine – it is a temporary thing. Reducing intake of methionine by about 40% can be quite a benefit.

      • DottyJ October 15, 2013 at 7:34 am # Reply

        Thanks for the quick response. I guess I’m really wanting to know what is a high intake? I’ve looked at the information provided on the link but I’m still not sure what a daily intake would be.

        I have a pretty healthy diet and cook almost every meal at home from fresh ingredients. I don’t eat bread more than maybe once a week, don’t eat red meat, eat chicken maybe once a week and fish (salmon or tuna) twice a week. Lots of fresh fruit and veg as well as juicing. So at a dietary level it appears I’m doing the right thing, however it would be useful to understand more on the methionine levels that I should be having.

        Hope this makes sense! I’m new to all this. BTW I have a homozygous C677T MTHFR mutation.


  115. Jill October 24, 2013 at 11:05 pm # Reply

    Dr. Ben,

    Thank you for providing your services. I believe your work and commitment to the community will pay off! I am a 37 year old relatively healthy female. I exercise regular; yoga and tennis, I don’t smoke, do drugs, or drink alcohol and I generally work on having a positive attitude. About 6 years ago, after giving birth, I began to get physically ill after eating certain foods. Within minutes to a few hours I would be in severe abdominal pain coupled with diarrhea and or vomiting that would last about one hour. Then I would recover as if nothing had happened. I had seen an allergist, but I did not test positive to any food allergies, except to peanuts and almonds and dust mites. On my own, I began an elimination diet of dairy and egg, I generally felt better in that I wasn’t throwing up or experiencing diarrhea as long as I avoided dairy and eggs. Two years ago, I stopped eating wheat/gluten and many symptoms were relieved such as headaches, lack of concentration, insomnia, and elimination of abdominal bloating. Blood work has revealed that I have food intolerances to dairy, milk (casein), egg whites, baker’s yeast, brewer’s yeast, oats, sweet potato, crab, garlic, tuna, wheat, red bean, red beet, any cheese from a cow, chestnut, dates, fennel, ginkgo biloba, ginseng, hops, kiwi, licorice, mussel, nutmeg, oyster, parsnip, sorghum, turmeric, and whey. I recently received my results from 23andme which indicated that gene C677T (homozygous) is mutated; which i think explains my food issues. Is that accurate? Is there a correlation between the mutated gene 677 and food intolerances? I eat pretty cleanly by making most of my own food. I am extremely cautious when ordering food out; in fact, I haven’t eaten out in a while. If I do eat out it’s likely a salad or rice or rice noodle with vegetables. I have been taking the following supplements: digestive enzyme, alka-pan, alka-green, and a probiotic. I stopped talking an oral contraceptive. I had my old dental filings removed as well. I mostly drink water but I do treat myself with sweet-tea. I was taking a vit C and D supplement but I wasn’t sure if it was a good product and it it was being received by my body so I have temporarily stopped. I feel like I’m doing most of the items on your protocol with regard to general nutrient recommendations for C677T MTHFR mutation. I’m open to taking the Optimal multivitamin, Optimal E, Optimal Tumeric, Liver Nutrients,Liquid D, Krill oil, but how do I know if they are appropriate for me with regard to my food intolerances? Can you address that concern? Also, what product (s) do you recommend to address the Glutathione, pyridoxal, silymarin, phosphatidylcholine, nattokinase, & Vit. C. Lastly, Dr. Yasko recommends getting homocysteine levels checked, as well as getting a Urine Amino Acid baseline, & Taurine level baselines. Are those baseline tests necessary prior to starting your protocol? Thanks in advance?

  116. Jill Yeagley October 29, 2013 at 8:28 pm # Reply

    Thank you – I really appreciate your highly informative website. You say that any gas stove/oven should be removed. Is that because of the contaminants from the gas? Also, I see that you only recommend Seeking Health products. What is your affiliation with this company?

  117. April November 5, 2013 at 1:47 pm # Reply

    Dr. Ben,

    I am compound heterozygous for the mutations, C677T and A1298C in the MTHFR gene and heterozygous positive for the prothrombin 20210G>A gene mutation. I found all this out because I had a DVT in March of this year. I want to begin supplementing for my mutations, but I am now required to take Coumadin for life. Will the supplements from Seeking Health interact with Coumadin (I’ve noticed they have a lot of green vegetables in them)? If so, then can I just order methylfolate from another company and it be just as good? I realize it won’t have all the added nutrients that Seeking Health multivitamin has, though.

    I would love to find a doctor who can help me with this, also. Does anyone know of a doctor in the Dayton, Ohio area who is familiar with correct MTHFR treatments?

    Thank you so much!

  118. Kelly Harrington November 10, 2013 at 11:52 pm # Reply

    Is there yet a comparable protocol for addressing A1298C ? I am heterozygous for both, but the psychiatric complications are the trickiest and potentially most detrimental right now, and I really need help navigating this in a way that protects my brain. Specifically wondering which additional SNPs to test for and order to be addressed with suppliments to avoid creating psychiatric side effects. Any info deeply appreciated… Especially if links to research availible.

  119. Amy November 12, 2013 at 11:16 pm # Reply

    Avoid Gluten??

    I tested negative for gluten allergy, so do I still need to eliminate gluten from my diet?

    I am reading this wealth of information and finding myself at a but of a loss on where to start.

    I was told I have one copy of MTHFR and I am not sure which one. I apologize for my vague lab references, but I have been receiving similar results my entire life- I have a low IGa, periodically have labs reflecting “borderline” hypothyroid and anemia.
    I have struggled with life long issues with IBS and Chron’s, migraines and fatigue, PCOS, anxiety, depression, and bi-polar. Not to mention recurring respiratory issues, recurring mono, frequent to chronic (periodically) yeast infections and UTI, and chronic body aches and pains.

    My previous dr (I recently moved and struggling to find a new doctor), had me on activated B12 and folate, probiotics, P5P, and I was doing ok, but have been feeling off to ill for the last several weeks. So, I am at the end of my rope and willing to try anything. I am a bit lost on what diet to start on and how. Do I just raid my pantry and throw everything out and start over?

    Any thoughts are welcome.

  120. Cat November 15, 2013 at 8:50 pm # Reply

    Hi Ben,
    Thanks for the information. I really appreciate all the help I’ve gotten from this website so far.
    It sounds really quite difficult to balance one’s methylfolate– in fact, it sounds so hard that I wonder if anyone on methylfolate would be able to truly relax and not have to think about it for a while (apart from when one is taking the supplements, of course). Is it really as depressingly difficult as it sounds?

    • Dr Lynch November 16, 2013 at 6:41 am # Reply

      Hi Cat –
      It is actually pretty easy. The trick is to ‘feel’ when you need it. In the beginning, you’ll either respond favorably – or not.

      If an unfavorable response, then you stop, reduce oxidative stress and evaluate your diet. If eating high enough amounts of uncooked leafy greens, perhaps you are set and do not need more methylfolate.

      If you have a favorable response, then you maintain that dose for a few days and see how you go. If you continue to improve, then possible raise the dose if improvement is slow – but if improvement is rapid and significant, then you shouldn’t likely take a higher dose – and in fact, you may want to skip a day or two.

      Look for the ‘peak’ and identify how you feel at the ‘bottom’ and the ‘top’ – note all symptoms when at each of these areas and jot them down.

      If you take too much methylfolate, then you take some niacin and some hydroxocobalamin. Easy fix.

      If you take too much niacin and hydroxocobalamin, then you take some more methylfolate ;)

      It’s a pretty cool system.

      The trick I am finding is people need to identify their oxidative stress levels first along with their level of nitrotyrosine and nitric oxide – and SAM/SAH ratio and homocysteine levels – or you can just jump in and see how you go – especially if you’re doctor has already prescribed it for you.

      • Mark November 16, 2013 at 6:51 am # Reply

        Dr. Lynch – All due respect, but I believe you meant to say, “If you take too much niacin and hydroxocobalamin, then you take some more methylfolate.”

        • Dr Lynch November 16, 2013 at 8:05 am # Reply

          Oops – yes – you are right – will review my statement – writing too quickly – thank you!

      • Cat November 19, 2013 at 6:54 pm # Reply

        Thanks. I appreciate your help :)

  121. Jay November 28, 2013 at 1:30 am # Reply

    Hi dr Ben,
    I have cfs and tested positive for 667 hetero, I started on Thorne multi guard plus was going great for 10 days then felt terrible, tried taking quarter pill every second day after a break then after a week terrible again, I’ve now tried yaskos multi, 1 tab every second day and sick again after a week, which one of you products should I start on and how much? I must say I have had some days of great well being and mental clarity before the bad symptoms came…

  122. Tara December 29, 2013 at 3:34 am # Reply

    Hi Dr Ben!

    I recently participated in a sarcoma study by and received a whole lot of info on my genome. I wade through it periodically and was surprised to learn of my heterzygous MTHFR status tonight. I ran it through genetic genie to get an easier to read/understand version. Here is what I found:
    Heterozygous mutations:
    MTHFR C677T, MTHFR A1298C, MAO-A R297R, MTRR A66G, MTRR H595Y, MTRR K350A, MTRR A664A, BHMT-02, BHMT-04, BHMT-08
    Homozygous mutations:
    COMT V158M, COMT H62H, VDR Taq, CBS C699T

    I successfully carried 2 pregnancies. My second was a 36 week delivery due to pre-eclampsia. I have had an early miscarriage. I am hypothyroid, but well controlled for the 4 years since diagnosis. I have RRMS, chronic fatigue syndrome, migraines and mild psoriasis. I had Ewing’s Sarcoma and it has been in remission for 6 years.

    I currently take 20meq Potassium and 50mcg Synthroid. I do take Cambia prn for migraines and will be restarting Tecfidera (MS DMD) very soon. I do take a regular multivitamin, super B complex, turmeric, fish oil, d3 and GLA.
    What would you recommend I take?

  123. Ken January 3, 2014 at 4:27 am # Reply

    This is a very easy to understand article, which is a boon when so many MTHFR articles seem extremely complex. Considering so many people suffer from some sort of MTHFR gene mutation it is important to offer information that people can digest and understand easily, very well done!

  124. Crystal January 11, 2014 at 4:37 pm # Reply

    Dr. Ben,

    I am new to your site and was just diagnosed as homozygous for the C677T mutation. I am 33, but have been trying for many many years to figure out exactly what is going on with me. Since a child I have always slept at least 11 hours, but always remain fatigued. That was just the beginning of my issues. Even to this day I get at least 10 hours of sleep but never feel rested. About 3 years ago I tried the HCG diet. Within 3 weeks I felt like a brand new person and had energy and was actually able to stay up till 10pm. While doing that diet was when I discovered I had a gluten sensitivity. So for the past 3 years I have been GF. That has improved my stomach issues (including achy joints as a child and constant bloating). I also had a colonoscopy and endoscopy to test for celiac, but everything was negative. However, I should also mention I was already GF at that point and only ate gluten for 3 weeks before the test and I am not sure if that would be enough. I thought being GF would also help my fatigue, but it has not. So I just recently started seeing an endocrinologist. I thought maybe there was more to the food, so I have gone back on an all protein, veggie and certain fruit (low GI foods) no starch diet for the past few weeks. So far I haven’t felt much improvement. However, the endocrinologist is the one that tested me for MTHFR. My homocysteine level came back as a 10. The Dr. was going to put me on 15mg of deplin, but it wasn’t covered by insurance at all so instead he had me order 15mg of methlyfolate which I will be starting once it comes in. After reading all these posts I hope that isn’t too much to start out with. The Dr. said we would start there and then see if I can go down to 10mg.

    There is a lot of information here and a lot I can relate to. For example, cervical dysplasia which I had many years ago and increased allergies too foods that now I have to carry an epi pen. I also should point out that for 17 years I was on the birth control pill. I stopped that 6 months ago, but just went on the paraguard IUD since there were no horomones.

    Would you agree that I am going down the correct path? Do you have any recommendations since this is all new to me.

    • Amee January 17, 2014 at 3:03 am # Reply

      Dear Crystal: have you had thyroid and adrenal testing for your fatigue? FWIW, i have the same mutation and had a very bad reaction to 7 mg of folate. It seemed to increase my adrenaline, which was already high (probably due to undiagnosed low cortisol). You might want to start low and work your way up. Maybe it doesn’t matter if you don’t have high adrenaline like i did. You can buy folate over the counter starting at 400 mcg. Hope you feel better soon.

      • Crystal January 17, 2014 at 1:45 pm # Reply


        Thank you for responding. I recently had my thyroid tested. All of my numbers appeared to be in range (TSH 93), but the Dr. put me on the lowest dose of levothyroxin anyway because he said my thyroid was slightly enlarged. He thought it may reduce that and improve my other symptoms. After one month I felt no different and there was no change in my thyroid size. Only my TSH went down to 40 something. So he increased the medicine to 50. In regards to Adrenal Fatigue I was put on a strict diet of only protein, veggies and fruits (all low GI scale) for the past 3 weeks in hopes that would help. I have stil not felt a difference. I was also tested for Hashimotos and that was negative. However, I read recently that because I have been GF for 3 years there is a chance that could have skewed the antibody test for Hashimotos. Someone actually recomended that I eat gluten again for a period of time and get retested. Do you have any history with that at all?

        • Amee January 17, 2014 at 4:24 pm # Reply

          Dear Crystal: I strongly recommend you read about the thyroid issue on this website:
          It will explain why TSH is not the right test and which ones are, and also how certain thyroid supplements are not the right supplements for many thyroid issues, and the issue of gluten.
          I found it incredibly helpful and eye-opening and bought the book as a reference. I am not financially connected in any way to the website or book, it was just the best information I’ve ever found on my health issues and I have been reading a lot.

          • Crystal March 15, 2014 at 3:15 pm #

            Dear Amee, Thank you for all of the recommendations. I am happy to say that my Dr. decided to take me off the levothyroxin and now I am just taking the methylfolate and methylcobalimin. I have definitely seen improvements in my fatigue level going way down and being more alert during the day. I would say I don’t really feel any side effects which is good. However, I am writing because I have read other posts and and I noticed Dr. Ben said he recommends lower levels of Methylfolate and if you are on a higher dosage something else may be wrong. I have been taking 15mg of methylfolate for about 2 months now and feel pretty good. Is it normal for a homozygous C677T individual to need these higher levels? Are there other things that I should be considering to get checked out. After being on the methylfolate my homocysteine levels decreased from 10 to 6.6.

  125. Jason January 16, 2014 at 5:30 am # Reply

    Dr. Ben,

    My wife has had several chronic conditions as long as I’ve known her including Chronic Fatigue, Fibromyalgia, migraine and other conditions. Recently she’s been practically fully disabled by knee joint pain that, according to 2 orthopedic docs, and a rheumatologist has not no explainable source. She’s been prescribed pain medications like Lyrica and Cymbalta (sp), and has been given high does of prednisone with note noticeable improvements.

    One of the many tests performed by the doctors she visited was an MTHFR genetic test which identified that she has 2 copies of the C677T mutation.

    Based on the reading I’ve done on your website, it seems like this could be contributing to her issues, but I have a couple questions:

    1) Is there any plausible explanation for her recent deterioration and specifically knee issues that could be related to this gene mutation?

    2) Do you have a specific recommendation on how to introduce the suggested supplements so that we can be sure they are having a positive impact?

    Thanks in advance.


    • Amee January 17, 2014 at 2:59 am # Reply

      Dear Jason: I wonder if you have any mold in your house. I moved into a new house and months later starting having unexplained nerve pain as well as earache and muscle pain (went to many doctors). One doctor asked me if I had mold in my house and, while none was visible, an air test resulted in black mold. It turns out it was behind paneling in the basement, due to a crack in my basement wall where water was coming in. My pain went away the day after the mold was removed. Anyway, just a thought. For the fatigue and other issues, I wonder if she has had thyroid or adrenal testing? Migraines can also be caused by magnesium deficiency. Hoping you find answers soon.

  126. Becca January 17, 2014 at 2:38 pm # Reply

    Hi Dr. Ben –

    I was diagnosed Compound Heterozygous MTHFR and homocystinuria just over a year ago after having recurrent miscarriage (three). I have two very healthy boys ages 5 and 7 and both pregnancies were easy and uneventful. Both boys were born very healthy and have no health issues. My question is, what happened? Could the interventions I had with both of them during labor (epidural and pitocin) have triggered the MTHFR and homocysinuria? If i inherited this from my parents, why weren’t these conditions an issue with my first two pregnancies? I have a healthy medical history although I’m pretty sure I deal with bouts of mild depression/hormone issues.

    Sadly since my diagnosis I have done very little to help my condition (I did at first, but I got easily discouraged and very overwhelmed with it all). I have actually gone the other direction and gained 15 pounds over the last twelve months and have ceased exercising. I do take my Seeking Health Optimal Multivitamin when I remember.

    I read your response to Janet (she is comp het as well) and I have written down what you suggested she take as far as supplements are concerned and would like to start my own protocol too. Since we are both comp. het. everything you listed for her is alright for me to take as well, correct?

    Please help.

  127. Jenny January 17, 2014 at 11:14 pm # Reply

    Hi Dr. Ben,
    Wow it’s great to find your site and thank you for your dedication to this seemingly new area of study. I found I’m homozygous 677T and want to get pregnant. I’ve been on a long journey of figuring out what the heck has been going on with me. I have been untreated for hypothyroidism for too many years, which led to Adrenal fatigue. I’m finally tolerating T3 and I’m feeling better than I ever have. My diet is 90% organic, mostly paleo, no sugar, caffeine, dairy, gluten, or alcohol. I eat leafy greens and sometimes juice them. I have a far infrared sauna that I try to use regularly. I exercise and don’t eat processed foods. I’m starting to understand which supplements to take and I am working with a practitioner who is knowledgeable in MTHFR. My question is: what do you recommend along with the prenatal that is mentioned above? I take D3, fish oil, C, and I try to eat a little liver daily (I freeze and make liver “pills”). I started a Methyl Mate B yesterday which contains 66mcg of 5MTHF and I first felt very energized and then got a little anxious. I also had insomnia last night. Nevertheless, I do feel a vitality that I’ve only felt intermittently. Thank you for your feedback. I wish you were available for a consultation!

  128. Kristi January 23, 2014 at 6:48 pm # Reply

    Hi Dr. Ben,

    Thank you for helping so many. I was searching for the symptoms of C677T and found this page, but read on one of your pages a response you wrote to someone “Being heterozygous C677T MTHFR is a risk but not significant.”

    I wasn’t sure after seeing that if I should approach my issues from the MTHFR diagnosis angle or not. My test says positive for one copy of the C677T mutation, heterozygous for C677T.

    My Mom has history of a large meningioma. I have serious structural and muscle pain for 26 years, migraines, ringing in head, chemical sensitivity, brain fog and recently my GI became too painful for supplements, and more.

    It looks like quite a process to recover via the protocol you have so generously posted, so it would be a shame to be barking up the wrong tree :)

    Thank you so much.

  129. Tricia February 17, 2014 at 10:45 pm # Reply

    Dr Ben:

    I have a copy each of 677T and 1298C and have Factor V Leiden. Which part of your protocol should I use>


  130. Angie February 21, 2014 at 1:57 am # Reply

    I am homozygous C677T and I am avoiding folic acid, but do I have to avoid cyanocobalamin as well? I am buying non dairy milks and they have Vitamin B 12 added to them, they do no list what kind it is. Do I assume that it is the cyanocobalamin?


  131. barb February 23, 2014 at 11:43 pm # Reply

    Dr. Ben – how can one make a Skype or phone apt with you – I am in Canada and our medical drs no nothing about this stuff. I have double mutation for C677T and none for the 1298. I have severe digestion issues, chemical sensitivities now at 49 and oral allergy syndrome. My diet is very limited since getting sick aug 2012. I had a hysterectomy in sept 2011 and by the next year anything I ate went through me and I went from 170 lbs to 106 (currently 112lbs 5’5 female). They did a colonoscopy/endoscopy and found lymphocytes but all looked good so diagnosed with lymphocytic colitis. Nothing worked to reduce my inflammation and I started becoming sensitive to even the water I was drinking. I had severe geographical tongue and still have patchy spots now and then even after just recently thinking to stop using fluoride toothpaste. I have histamine issues as well and recently discovered this after stopping yogurt/bananas/avacados/blueberries shakes I had 3x daily. My 6 bowel movements a day immediately stopped to 1 but I can’t eat anything but chicken and beef and bison and asparagus and green beans. all organic. I have tachycardia big time whenever I eat. So where do I begin?? I am on ketotifen for the histamine and entocort steroid for the inflammation and LDN for inflammation as well. What can I do to bring my health back? I am very sensitive to vitamins so don’t take any and haven’t in over 1 1/2 years. Also gluten, sugar free (except some coconut nectar or palm sugar in flourless peanut butter muffins) for over 1 year now. I am afraid to try any supplement. I do Epsom salt baths almost every other day for 15mins soak. I finally feel I have my candida under control. Where do I go from here??? Do you offer appts ?
    barb from alberta, canada

  132. Cathy February 27, 2014 at 11:15 pm # Reply


    I’m new to this site and all that it covers . . . Is anyone taking 5-MTFHR for Crohn’s Disease? My husband has Crohn’s but hasn’t been tested for mutations.

    Thanks for any information you may have to share,

  133. Victoria P February 28, 2014 at 10:40 pm # Reply

    After 10 or so years of symptoms, I was finally diagnosed with this mutation a month ago (I’m 20) and am still learning about maintaining it. My doctor gave me Active B12-Folate with 800 mcg of methyltetrahydrofolate and 1000 mcg of Vitamin B12 (methylcobalmin) and told me to take 2 a day right away.

    Well that was a horrible day I have to say. I felt “not right” and had pressure in my chest and felt like I couldn’t breathe; not to mention quite a few panic attacks. I went down to one a day and weathered through it and am still only taking one a day. Now I’m just having the occasional chest pain and migraines and headaches and overall “not right” feeling.

    Does this have any link to GI problems? Chest, skin, joint, and especially abdominal pains are the bane of my existence.

    • Steve Thompson March 1, 2014 at 9:49 pm # Reply

      I was diagnosed with MTHFR 1298C +/+ about eight months ago. My doctor recommended Thorne Methyl-Guard Plus, which contains 1,000mcg of methyl-B2 and 800mcg of methyl-folate. That had me sleeping about one hour a night and feeling like death.

      He had no idea what to do next, so it was up to me to find out what was going on by experiment. I bought the individual components of the TMGP and added each one at a time. All was going well until I added the methyl-folate last.

      To cut a long story short, I’ve been doing lots and lots of reading and supplementing with other vitamins and minerals and trying occasionally to add small doses of folate.

      Some doctors (most doctors) have no idea about the intricacies of treating something like MTHFR. They were taught to treat in a way that links one symptom to one disease to one test to one drug. They were taught to remember lists of facts; they weren’t taught to think. You need to either find a doctor or alternative practitioner with detailed knowledge of MTHFR treatment.

      I’d also suggest to not just treat the MTHFR defect. You need to do the test or the test to determine other defects in your methylation genes/enzymes.

  134. barb March 1, 2014 at 7:16 pm # Reply

    HI, no one seems to be managing this site??? there hasn’t been responses to anyone’s comments for quite some time???

  135. Kimberly March 4, 2014 at 1:37 pm # Reply

    Dr. Lynch,

    I read that instead of taking glutathione directly, that it would be better to take glutathione precursors to encourage the body’s own production of glutathione. The reason being is the body is not readily absorbing the glutathione, but taking the precursors that encourage the body’s own production enables it to be absorbed. I’m wondering if you agree or disagree. And if you agree, is there a glutathione precursor supplement that you recommend in particular? Thanks!

    (FYI, I’m compound heterozygous C677T and A1298C following a Paleo lifestyle with stage 3 adrenal fatigue which I’m currently addressing with Mary Vance NC, hypothyroidism NOT autoimmune on Armour 60, and Crohn’s disease not taking any medication, 2 miscarriages and wanting to try to get pregnant soon as I’m 35 so the glutathione is one thing much needed for my healing!)

    • Dr Lynch March 5, 2014 at 10:06 pm # Reply

      Kimberly –

      Precursors are the ideal way – certainly – however – it is not just the precursors needed and then the body will make glutathione.

      It also takes:
      – healthy cell membranes
      – transport proteins
      – ATP
      – cofactors such as niacin, B6, B2, selenium

      Taking liposomal glutathione is a great way to boost glutathione levels. Taking reduced glutathione via a capsule is not effective as it breaks down readily in the stomach. The liposomal glutathione has been shown to raise blood glutathione levels quite well – and quite quickly. You want to be sure that the liposomal glutathione is non-GMO and non-soy. My company, Seeking Health, offers such a liposomal glutathione – as linked earlier in this comment.

      Also – do not take glutathione while pregnant. Simply support with precursors via protein and prenatal – much safer route.

      The Optimal Prenatal Protein Powder provides all amino acids, nutrients for pregnancy and supports methylation and MTHFR as well – and it is tasty/fast to take. I personally use the vanilla – I find that one better.

      • Tara March 5, 2014 at 10:14 pm # Reply

        I bought the Liposomal Glutathione for my six year old son who has Autism. He is always low no matter what I do with supplementing precursors. His skin clears up and he focuses so much better along with clearer and more speech while taking the Liposomal Glutathione from Seeking Health. Thank you so much Dr. Lynch!

      • Kimberly March 6, 2014 at 12:52 pm # Reply

        Thank you Dr. Lynch. I had one other product recommended to me which contained the glutathione precursors by someone who was helped by it tremendously with regards to adrenal fatigue (they are also MTHFR), but I was wary of it for the soy lecithin it contained. Your comments have me feeling it is inferior even if it didn’t contain soy.

        I was planning on starting the optimal prenatal vitamins. Do you recommend the prenatal protein powder over the vitamin capsules? I was comparing the product labels and they’re nearly identical for the components. My concerns with the powder are: 1) I’m Paleo AIP and the protein source is pea and rice which I generally avoid and haven’t tried reintroducing to see if I tolerate them (yet) and 2) the use of sunflower oil which is a highly processed vegetable oil high in Omega-6 and causing a host of problems in lab animals including reproductive difficulties (and likely humans). I know the liposomal glutathione is also made with sunflower. I realize sunflower is preferable to soy, but still undesirable.

        • Dr Lynch March 6, 2014 at 9:10 pm # Reply

          Kimberly –

          As I say often – “Everything in moderation”

          We need omega 6’s – not just omega 3’s.

          Being Paleo is fine for many people – but following one diet extremely is likely not balanced and may cause issues.

          I definitely recommend the Optimal Prenatal Protein Powder over the capsules for a few reasons:
          – Ease of use – so a pregnant woman is way more likely to get what she needs nutritionally
          – Offers complete protein – which baby needs for development – not just vitamins and minerals.
          – Morning sickness – has helped a few women (it’s a very new product for us) with severe morning sickness – stopped it cold.

          You have to balance your fats – and not be extreme. I am not saying you are extreme – but making sure you are aware that we need both fats.

          You can have your doc measure your RBC Fatty Acids and see how they are doing.

          • Kimberly March 7, 2014 at 4:43 am #

            Thank you Dr. Lynch. I think I manage to keep my Paleo lifestyle quite varied and nutritious, even while following the AIP temporarily. I have protein and fat at every meal, and starch/carbs at most as well. In other words I don’t adhere to the low carb and low fat myths. It is obvious to my body that gluten and grains are not a friend as evidenced by the disappearance of bloating and weight from the mere removal of these products from my diet in August. My health issues will hopefully resolve now that I’ve gotten help to address severe adrenal fatigue and all its implications.

            And I do agree we need balance in our fats, but I guess I just feel there is a better way to get Omega 6 than from a highly chemically processed vegetable oil. I’ll start with the capsules preconception and consider the powder if/when I become pregnant.

            Thanks again.

      • Sandi April 22, 2014 at 9:45 pm # Reply

        dr. lynch,

        a doctor recommended liposomal glutathione for me (tri-fortify orange). my ob did not ok it for pregnancy, but what about breastfeeding? do you know if it is breastfeeding safe?


  136. Liza March 9, 2014 at 12:26 am # Reply

    Hello all,

    I had a pulmonary embolism back in Dec 2012 and learned that I am heterozygous MTHFR c677 – i have no idea anythinga bout 1298 b/c i don’t think i’ve ever been tested for it. I was on thinners for several months and am currently not taking anything – the doctors around here all kinda blow me off, saying “it’s no big deal” and I realize that having only one copy is less severe than being homozygous, but it was severe enough to give me a blood clot in my lung. I have chronic pain and cramping in my abdomen, back, chest, etc and no one can seem to figure out why, so I am wondering if MTHFR can cause that kind of pain. I honestly have no idea how to feel better so I think I will try to follow the protocol from teh above list (thank you for making such a great and easy to understand page!). I’m so frustrated that no one here, medical professional wise, can give me any information. One person I saw couldn’t even get the acronym for it right. Do you have any advice and can you tell me if pain like that can be related to this?

    Thanks! Liza

    • Liza March 9, 2014 at 12:40 am # Reply

      I forgot to also mention that I have fatty liver and my ALT and AST are always slightly elevated, not by much, but around 10-20 above normal. Can that have anything to do with this as well?

  137. Jackie March 9, 2014 at 11:05 pm # Reply

    Dr Lynch,
    I have had a rough 9 months after taking Bcomplex100 (1day) and bcomplex 50 for 15 days…neuropathy, pins and needles started and then severe leg muscle pain that hasnt really gone away yet. I was told to stop all supplements my neurologist said it was from the b6 and it would take a long time to heal my damaged nerves of b6 toxicity. 9 months later I havent eat fortifed cereals, taken vitamins and my dr has been thinking it is thyroid due to pain, hair shedding, coldness etc. but all meds like armour havent really helped me either so I asked to be tested and Friday I found out I am C677T homo type. I ordered the active b12 and the L-5mthfr b12 it should be here this week. I started Krill oil today and low dose asprin, already take probiotics(womens 90 billion) I am trying to find a Dr to help me treat this around my area, but is a start? and do you think the bcomplex in Aug bascially poisoned my system since that is when all my pain started? would niacin help relieve it or help clear the toxins? thank you for your time. ps I have been tested for everything you can think of, and know all my vitamin levels,most are very low including b6
    that I am scared of now.

  138. Tricia March 23, 2014 at 5:19 pm # Reply

    2 1/2 weeks ago my doc gave me a 2 week sample of deplin 15mg. I am homozygous for c677t 2 copies. I can’t afford deplin so I bought Life Extension optimized folate 1000mcg and began that a few days ago. For 2 days now I’ve been dizzy and faint. There’s a roar in my head, a swishing and ringing in my ears. I’ve stopped taking all supplements and it hasn’t waned at all. I’m curious if my body readily accepted 15mg then went into shock by switching to the reduced dose in micrograms. I’m not sure if I should stop my folate or take 15 of them. Or it could be something else entirely. I also started taking AdreCorwith licorice root for my adrenals and it has the methyl Bs in it. Help.

  139. Dawn March 25, 2014 at 6:11 pm # Reply

    so much information. I am overwhelmed. I have recently discovered I am homozygous for c677t, although I have not, to my knowledge, ever had any related issues. I have always been healthy but have family history of various catastrophic vascular events. Since Jan of this year I have been battling a flare up of uveitis of unknown cause, and ran across this site because I suspect that in the next treatment step my doctor will want to try methotrexate.

    My husband is also homozygous for c677t and had a stroke at 42 which was when we found out. That was 06 and his doctor has had him on Lmethylfolate calcium, 15 mg. I have begun taking it too with no noticeable effects, positive or negative. I am concerned about anything that could be a contributor to inflammation because of my uveitis. Our doctor seems to think the supplement is all that is necessary. husband also takes niacin, baby aspirin, and Crestor for elevated cholesterol. I do not supplement currently other than the methyl folate. our diet is on the healthier side of average but could definitely use cleaning up.

    we have 3 kids ages 2, 4, and 7 who by default are all homozygous, no testing necessary. Oldest has ADHD, middle has chronic acid reflux, and youngest has recurrent eczema outbreaks on her hands and feet of a type unusual in children. I do wonder if any of their issues could be due to the mutation. It is primarily for them that I am posting as finding info on supplements for children and proper dosage has been difficult. thank you for the guidelines you have posted as they are the first I have seen that directly address supplements for children. their ped has never even heard of MTHFR and I have read elsewhere where parents were told not to bother until their kids were older. Seems to me that damage is already potentially occurring by then.

    looking forward to exploring the site further. Thanks for your efforts here.

  140. Kristin March 30, 2014 at 11:44 pm # Reply

    Dear Dr. Lynch,

    Recently had blood work done for my husband. His results came back as homozygous T/T MTHFR677 and homozygous A/A MTHFR1298. The doctor we saw gave him metafolin 400mcg and methylcobalamin 1,000 mcg. He was told to take it twice a day. There were other concerning things on his blood work that he didn’t really touch upon. I’m nit sure the doctor knew how to address them. We would appreciate any feedback. 26 yo male

    DHEAS levels (H) 572
    Testosterone 334
    Alpha-HB (H) 4.6
    adiponectin (L) 9
    Vit B12 (L) 321
    RBC Folate 922
    Apolipprotein B (H) 72
    Ratio is (L) .47
    Insulin (H) 11
    25 hydroxy (L) 20
    Proinsulin (H) 12
    Fructosamine (H) 315.09
    Hgb Alc% 4.9

    Thank you for all you do.

    Note: Both our young sons and myself are getting tested. Both our boys have high functioning autism.

  141. Camilla April 2, 2014 at 2:04 pm # Reply

    Hi Dr. Ben,
    I am homozygous for the C677t allele in the MTHFR gene. How does epigenetics play into this gene mutation? Is it possible with good diet and lifetstyle to not have the gene expression or do I need to assume that the gene mutation will require lifelong supplementation of methylcobalamin, methylfolate and baby aspirin?
    My doctor prescribed metanx with 3mg of methylfolate and 2 mg of methylcobolamin. I did not tolerate that dosage such that it made me very irritable. I now take half of Seeking Health Active B12 (400 mcg methylfolate, 500mcg methylfolate) and a baby aspirin daily – amongst other supplements like omega 3, vit D, COQ10, etc.

  142. Brenda A April 3, 2014 at 2:34 am # Reply

    Hello Dr Ben,
    I have had problems with medications for most of my life, was found to have CYP450 disorder about 6 years ago but continued to have reactions to meds, even the smallest amounts. About 5 months ago I had reactions to everything including my thyroid medication.. had to be taken off of it. The reactions continued culminating in severe reactions to almost all foods 3 weeks ago. The only things I could tolerate were organic beef and chicken.. have been able to add organic rice cakes, watermelon and organic sweet potatos in very small amounts.
    Found last Monday that I have Mthfr TT and was put on a plant based B12 with plans to add B complex etc. I started having serious welty rash, diarrhea and chills within a few days of starting the supplement. After checking with a nutritionist I found that all the plant based B12′s have brewers yeast in them and she said I should not have any of those because I need to be on low histamine and that is not tolerated, methylcobalamin was recommended but all the supplements I’ve found for that have folic acid and I’ve
    been told that will do alot more harm than good, that its folate I need not folic acid. I’m feeling like I’m walking a tight rope..I’m was just starting to get my symptoms manageable from 6 months of reactions. I know I’m allergic to sulfa and nsaids.. have always had reactions to sulfite foods. My hypothyroid is untreated now for 5 months and was also diagnosed with fibromyalgia. Thank you for your help, hoping you can give me some clarification on which supplement is best.

    PS, My daughter has been diagnosed with Mthfr (1 T) and they took bloodwork on my grandson as he has multiple allergies.

  143. Liz April 3, 2014 at 5:21 am # Reply

    Hello Dr. Lynch.

    Hetero c677t

    I am a 21 year old female who has been on birth control for around four years now (bad menstrual cramps).
    Although I am only 21, I had a stroke about three months ago. And was having non-epileptic seizures (dizziness) as a child. I just learned I have this mutation last week and so all of this is new. But I want to show by example how severe this can be. 21 with a stroke?!?!

    Anyways, I have read a lot and I do not understand why reducing the intake of methionine is advised? Because the problem with the pathway is not being able to convert the homocysteine to methionine. And so it would seem logical that there would be lower levels of methionine and therefore we would want to increase our intake of it. Also, is metanx not as advised?

  144. Brenna April 9, 2014 at 3:18 am # Reply

    Dr. Lynch- thank you so much for this comprehensive website. I am just getting introduced to this whole world and I feel quite overwhelmed, but these resources are helping to clear things up. I am fortunate to only have a heterozygous C677 mutation and no 1298 C mutation. However, I am homozygous for both COMT and MAO-A. I had a very bad response to starting with Methylfolate (in MethylGuard) likely secondary to the COMT mutation. I have done a lot of reading and have come up with two questions that would be very helpful to have you answer.

    1) Dr. Amy Yasko seems to emphasize addressing Lithium levels before supplementing with B12. Is that really important? I’m hesitant to mess with anything that does not need to be addressed as I seem to be pretty sensitive.

    2) With the addition of COMT and MAO mutations- is the hydroxycobalamin a better source of B12 than methylcobalamin? (I seem to be pretty sensitive to anything that has “methyl” in it- like I said, I’m new to this so maybe I’m oversimplifying).

    My plan is to begin with the Optimal Multivitamin and move on from there, but I would love a little input as I want to avoid the roller coaster I was on when originally put on multiple supplements by my naturopath.

    Thanks so much,


  145. Michelle April 10, 2014 at 7:14 am # Reply

    I have one copy of C677 and have a child born with a few defects before this was discovered. A recent miscarriage at 15 weeks discovered the MTHFR by chance really. A friend told me to get tested….not a doctor. Turns out my six year old has the same copy too. I am desperate to try for another child as the loss of my baby was after 3 years of IVF. Currently on the Seeking Health PreNatal vitamin you recommend, was taking baby aspirin but getting stomach aches/reflux. Is there an alternative thinner or what do u suggest I take each day? Can I over methylate on these prenatal as the label says to take 8 a day but I feel the last two in the afternoon cause me to crash and be very aggitated at night. I await your wisdom.

    • Lynn_M April 12, 2014 at 6:05 am # Reply


      Your agitation at night is an indication that you may not need the amount of methylfolate in 8 pills a day of the prenatal vitamins. With only one mutated copy of C677T, you’re still able to make a fair amount of MTHF, so you wouldn’t need as much methylfolate as someone with two mutated copies.

      And with only one mutated copy of MTHFR, it’s less likely that is the reason for your miscarriage after 3 years of IVF. However, if the father has any MTHFR gene mutations, it’s possible the fetus could have had two copies of MTHFR mutated genes. You need to look at both your genes and the father’s genes to see if there are any other likely causes or mutations.

      • Michelle April 13, 2014 at 3:13 am # Reply

        The father has been tested and he carries no mutated copies of MTHFR. I find it to be a real coincidence that as soon as I took supplements for C677 (a Prenatal) I immediately got pregnant after 3 years of IVF. The previous 3 years of IVF to give birth to my eldest daughter when MTHFR was not even known resulted in her being born with severe birth defects. The fertility clinic and doctors have all run many tests with the outcome being “Unexplained Infertility”. Time will tell if I am on the right track taking these PreNatals and now Baby Aspirin I pray that the jigsaw pieces have finally been put together as I am not getting any younger and there is a small window here.

        • Lynn_M April 13, 2014 at 3:35 am # Reply

          23andMe tests for 59 SNPs of MTHFR, so you may have mutations in any of the other MTHFRs. And there are a number of genes other than MTHFR that impact the need for folate, B12, B6, and other supporting nutrients. You might consider the Metametrix UMFA test – for unmetabolized folic acid and MTHF, to make sure you’re getting the right amount of MTHF. There’s information about it at Dr. Ben’s other website The conventional folate and B12 tests measure all analogues, both the active and inactive, of those B vitamins, and you may have had misleadingly high results, not reflective of your true active level of those vitamins. I also like organic acid tests (OAT) as a general barometer of a number of indicators.

  146. Dawson April 14, 2014 at 3:51 am # Reply

    I have this gene mutation and also have histamine issues. I was looking at the optimal vitamin but noticed red wine something in there, is this common to cause issues in others?? I am trying to figure out which one of your methylate pills would suit me best. I show only yellow on the gene mutation for this one. But I am also really sick with mold issues, histamine issues etc. So I am wondering if I need to look at a form of methylate? The vitamin one looked the safest. But I wasn’t sure.

  147. Pam May 11, 2014 at 3:03 am # Reply

    Hi Dr. Ben,
    Thank you for your website and ALL your effort and research…..I have learned so much.

    Through a blood test, it was identified that I have the A1298C mutation. Because I’m not responding well to my Doctor’s protocol, I wanted to get tested by 23andme.

    I sent in my sample and received a message from 23andme that I did not have sufficient DNA amount in my sample. I retook the test – followed the instructions precisely. The second sample came back with the same results….Not enough sufficient DNA in the saliva sample! How do I increase my DNA in my saliva????

    My Doctor is stumped….he has never heard of that before. HELP – I know I have other mutations – but how do I identify them if I can’t get my DNA levels up?

    Thank you for your help.

    • Steve Thompson May 12, 2014 at 1:54 am # Reply

      Hi Pam.

      I had the same problem, 23andme were unable to extract sufficient DNA from my saliva sample. They did refund my $99.

      I then bought the Methylation Analysis from Dr Amy Yasko. It’s a dry blood spot test. Some experts I have read think that this is a much more reliable method for DNA testing than the saliva sample method. Remember that the Yasko test is designed specifically for finding genetic problems related to methylation while the 23andme test is a very generalised consumer health risk test. The Yasko test is more expensive and takes longer but my impression is that it’s more reliable and accurate. Just my impression, for what it’s worth.


  148. Michelle Gienger May 22, 2014 at 11:59 am # Reply

    I have recently found out that I have 2 copies of C677T and I wonder what other tests I need to get the full scope of the genetics behind my health issues and now my family needs help too. The 23andme site no longer does genetic health testing, or that is where I could have had us get comprehensive tests.

    What can you recommend for testing, without a doctor’s order if possible? We don’t know doctors who have expertise in this and my doctor wanted me to take Deplin, so I needed a more natural approach…and found you.

    • Lynn_M May 25, 2014 at 11:48 pm # Reply

      Michelle Gienger,

      You are misinformed about 23andMe. They are still doing genetic health testing. What they are currently not doing for newer customers, because of orders from the FDA, is generating individual health reports about a very limited number of health conditions that a person’s genetic data would indicate a potential susceptibility for. These health reports never concerned methylation, and weren’t of much value to me, other than telling me I didn’t have certain very serious conditions.

      What I have found to be very valuable is the raw genetic data that 23andMe generates. I initially used Genetic Genie to interpret my methylation and detoxification gene test results (about 70 SNPs), then I used the MTHFRSupport Variant Report to interpret another 170 SNPs. Livewello provides a similar service. Then I learned how to use 23andMe’s Browse Raw Data feature, and now I use Google Scholar to search directly for any genes or SNPs. If a person educates themselves, there is a wealth of information that can be learned from their raw genetic data.

      I have read Dr. Lynch recommend 23andMe somewhere on these forums. No doctor’s order required.

  149. Denise fazio May 26, 2014 at 2:30 am # Reply

    My 18 y/o daughter has the c677t mutation and was recently diagnosed with hyperthyroidism and iron deficiency anemia. What supplements would you recommend. I know she needs to proceed slowly with the methylfolate since she has exhibited side effects in the past. Thanks for your advice!

  150. Joe May 29, 2014 at 6:17 pm # Reply

    Hello, I am homozygous for the C677T and neg for A1298C. Working on “fine tuning” my new folate/B12.

    My question is that I need IV Chelation to remove mercury and lead. Is there anything
    the Doctor should know before starting this chelation on me????

    Many thanks and thank you so very much for this awesome website!!!!

    Cheers, Joe

  151. Kristin735 May 30, 2014 at 2:00 am # Reply

    I think my ND was a bit too aggressive with my therapy and I’d like some guidance with starting back up again. Question after background info.

    I am C677T +/-, A1298C +/-. My chief complaints for seeking a naturopath was worsening chronic depression and nerve pain down both right arm and leg. I am hoping avoid adding any more antidepressants and ultimately get off Wellbutrin.

    She started me several months ago on 3000mg fish oil daily and 5000IU vitamin D3. My latest D3 level was 77. At my most recent visit she started me on several supplements at once. Magnesium Glycinate 120mg daily, increasing 120mg each week up to 360mg. Mineral 650 by PE 2 daily for 2 weeks then 4 daily. Methylcobalamin 5000mg sublingual daily. Multi-B Complex by Integrative Therapuetics 1 twice daily. Deplin 7.5mg 1/4 tab daily, increasing by 1/4 tab each week up to 1 full tablet (choosing RX version was my choice in order for insurance to cover it)

    I noticed no difference in my symptoms the first week or so. I had been fatigued before and continued to be fatigued. Then my fatigue started to get worse. I’d get up in the morning at 5 or 6am and by 9am I just wanted to take a nap. Of course I’m at work at this point. Caffeine couldn’t even lift me up out of the fatigue to the level I was at before supplements. I was feeling spacy, off balance, my thinking was sluggish and my energy was sapped.

    I contacted her about this and made the decision to switch to OTC L-5-MTHF by designs for health 1000mg daily as she had no experience with the RX form and didn’t feel she could reliably predict what results I would have on that.

    I then had my follow up appointment with her. My crushing fatigue had lifted the tiniest amount with the folate switch. We discussed my concern with the Kidney pain I had started to experience that was getting worse. She took a urine sample for culturing, CBC, CMP. The urine pH was off but everything came back normal on the labs. She had me increase the methylfolate to 2 daily for I week to then increase to 3 daily.

    Lots of reading by me on the internet and I changed from placing the B-12 under my tongue to inside my cheek. I got an ah-ha moment when the crushing fatigue began not even 20 minutes later. That was 5 days ago. I stopped all B vitamins on that day and I am back to me pre-supplement self.

    I’ve done lots of internet research and watched Dr. Lynch’s methylation You-Tube video.

    I know I will be eliminating the B complex that I’m currently taking that has folic acid in it.

    My question is this. The video implies that I should start back at zero supplements and start fresh. But at the end of the treatment cascade he mentions that we of course should have vitamin D, Krill Oil, etc in place also. I’m confused; what basics should I leave in place before starting the B vitamins again? The video says to start with methyl cobalamin but the website says to start with Optimal Multivitamin first for a heterogygous mutation. Which should I do first?

    FYI – thinking of replacing my b complex and mineral complex with Optimal Multivitamin. Thinking of adding mixed vitamin E 400IU daily. Thinking of adding vitamin C 2000-5000mg daily (MTHFRade?). Thinking about adding Calcium Citrate 500mg twice daily to balance out the Magnesium I’m taking.

    Thanks for reading through my ramble and for any advice you can offer.

    • Dr Lynch May 30, 2014 at 2:35 pm # Reply

      Hi Kristin –

      Information may vary in videos, conferences and on because I am constantly updating and improving my information and suggestions.

      I am going to be working on a laypersons course soon with some basic information. Currently, the information I have is pretty complex – at

      You may want to try B Minus – this is a B complex without any B12 or folate.

      Magnesium and trace minerals may also be useful. Calcium is typically overrated as a supplement.

      Vitamin C can be quite useful along with liposomal glutathione (but start very low at first – few drops at a time and increase slowly)

      • Kristin735 May 30, 2014 at 4:41 pm # Reply

        Ok, so b minus along with trace minerals instead of the Optimal Multivitamin. Skip the calcium . Already have magnesium on board. I’ll wait on the vitamin c for now.

        But what about the timing of adding the B supplements. Should I just add them now along with everything I’m already taking or take away some or all of what I am currently taking before starting to taper up.

        I didn’t have any problems following your current video as I am a pharmacist and have done quite a bit of online research . I found the explanations on the heartfixer website regarding the different enzymatic pathways to be helpful. I was just confused by the conflicting information. I realize this is an ever evolving protocol. I’m just trying to ascertain what your current recommendation is.

        Thank you for getting back so quickly. It is very much appreciated.

  152. David Cairns May 31, 2014 at 12:00 pm # Reply

    In the video “MTHFR and Methylation Advancements_ Q and A with Dr Lynch”
    Dr Lynch suggests starting cobalamin and Methylfolate at the same time. However his protocol starts them separately. I think he did this to avoid trapping, but he then says that this is no longer the case. Can anyone confirm.

    In the same video he also suggest taking Folinic Acid, but this does not appear in the protocol.

  153. Raphaela Deming May 31, 2014 at 7:26 pm # Reply

    For the past 14 yrs., I have consulted with a psychiatrist to overcome debilitating depression. Some anti-depressant have worked for short periods of time, but I have struggled more and more as the years pass by. Added to that, I seem to have Chronic Fatigue Syndrome and IBS.
    About a year ago I found a Naturopathic physician. Recently she tested me for the MTHFR mutation and tests confirm one gene mutation (C677T). Finally I see hope that I can reverse the downward spiral and find life livable. I am only just beginning on this path and hope the doctors I have at my disposal will be open to learning and applying all that you have discovered.

  154. Olga June 1, 2014 at 8:27 pm # Reply

    Hello! I just have been diagnosed for a1298c heterozygous mutant, I had 2 miscarriages, 1DVT , 2 pulmonary embolisms and have psoriasis and hypothyroidism also. My doctor told me this mutation is not as complicated as the 677 but still i had all this complications, this tests I send to the US because In Guatemala where i live they don’t do them, I’m worried that my doctor is not well informed to treat me, what should I do?? Help!

    I think I inherited from my father, he died of colon cancer.

  155. Elly June 2, 2014 at 9:27 pm # Reply

    Hi Dr. Lynch,
    Can Thorne’s Basic Detox Nutrients supplement be helpful for methylation? It has many of the components that you discuss in your supplementation protocols but what do you think about taking them at the same time in one supplement?

    Thank you,

    Elly Lieppman
    naturopathic medical student

    • Dr Lynch June 3, 2014 at 7:11 pm # Reply

      Hi Elly –

      It depends on the person. For some, it is great -for others – not so great. Have to give it a try and see how you do. Start low with the amount and work up.

  156. Abbey June 6, 2014 at 9:10 pm # Reply


    I just watched your presentation on the Thyroid Summit, Dr. Lynch. Fascinating, thank you! I am heterozygous C677T. I currently take a prenatal by Thorne with 1mg methylfolate in three capsules. I take two capsules. I feel fine–not extremely different from before switching prenatals, but I did notice that I get a small migraine (much less severe and shorter than I usually get) each month since starting the methyfolate. I notice heart palpitations each day too. Nothing major but there. I also have hashimotos and am on the autoimmune paleo protocol to help heal my thyroid–which is working! I am very healthy and active, but also PCOS, which could be caused from the hashimotos. Anyway, I try to consume a lot of turmeric. I notice that I crave it. I also started introducing liver into my diet. I don’t like the taste but I feel amazing after eating it. There is something in it that I need. Do you think I need to either reduce the methylfolate I am taking or take another supplement to counter act this? If so, which one? Thanks for your time!

  157. John June 7, 2014 at 2:28 pm # Reply

    I just got blood work back indicating that I have C677T TT. I am so glad to have found your website! I am inclined to start with the active B12 as I am not chemical sensitive. Based on other blood work I am wondering how I should modify the basic protocol. The directly relevant additional results are:

    Homocysteine = 8 umol/L
    B12 = 1359 pg/mL
    Vit D = 50
    Omega 3s = 10.3% total, 6.2% DHA

    So despite having C677T TT my B12 levels are high and homocysteine is optimal. I already take NAC, Milk Thistle, Turmeric, a cheap multi, ALCAR, choline (occasionally), vitamin C, magnesium/potasium, fish oil, and occasionally racetams. Most of this supplementation resulted from my concern over elevated liver enzymes in previous tests and a long term issues with focus and energy. Interestingly I have focused my attention on liver health and neurotransmitter support. It turns out this was the right track but I did not know about the potential genetic underlying cause.

    FYI: I am a 34 year old white male, 30lbs overweight, a grad student (so I do a lot of sitting while researching).

    Given that data, especially my homocytsteine and B12 levels how would you recommend I approach the protocol?

    Thank You So Much!

    • John June 7, 2014 at 7:13 pm # Reply

      I also take vitamin D and Primal Defense Ultra probiotic. I don’t know if it is relevant or not but I also regularly supplement general MCTs and/or Caprylic Acid in my diet. I try to follow a diet based around the most natural, high quality whole foods available, avoiding grains, dairy and sugar (on about an 80/20 basis).

  158. Danielle June 9, 2014 at 4:50 pm # Reply

    Hi Ben, I’ve had severe CFS for 25 years (since I was 16) & sleep onset insomnia since early childhood. I’ve just had results of MTHFR testing (C677T & A1298C) & it showed hetero for C677T only. I started using Methyl B12 & Methlyfolate around 18 months ago as I strongly suspected I had MTHFR issues & within 3 days felt a lot more energy. I have been strictly gluten free for around 8 years, I am dairy intolerant so occasionally have sheep or goat dairy only, I rarely eat processed food. I do have lots of gut issues & hormonal issues. My thyroid test always come back “Normal” & my DHEA levels are flatlined so I take supplemental DHEA. I know I have improved with taking the methyl B12 & Folate but I am still thoroughly exhausted & am bed ridden when not working (I am a TCM practitioner). I have suffered an on-going infection for 3 years that comes & goes, that is undiagnosed & get “everything” that is going around. A lot of what I have recently read re MTHFR & CFS seems to suggest that C677T is not so linked with CFS, yet I feel so much better on the supplements. It took 3 days to feel improvements & if I ever forget to take it, or can’t due to being unwell, it only takes 2-3 days before I am right back at baseline energies. Can you enlighten me of why I improve with these supps if it isn’t linked to CFS, are there any other tests I should get done, & what other supplements I should add to try to get my life back? Thanks in advance, Danielle

  159. Stefania June 11, 2014 at 10:57 pm # Reply

    Hi Dr. Ben –

    This is a great, comprehensive list of absolutely everything I have been wondering about since being diagnosed with homozygous C677T MTHFR. My doctor is always booked for months, and overbooked, so never has time to talk in detail about the questions that I wonder about every day. My brother, with the same mutation, was given 15mg of Deplin, so before I even saw my doctor, I started taking Methyllife L-methylfolate 5mg, increasing slowly to three times a day. When I went to my doctor, he gave me a B Complex vitamin with methylfolate (400mcg) to take twice a day. I thought it was weird that it was such a huge difference in dosage compared to what my brother was taking, and also a huge difference from what I then was taking on my own before seeing an endocrinologist.

    This list does seem very long, and I’m in my early 20’s and cannot afford to take so many supplements. Which things do you think are most important? I also have very bad stomach issues, and my doctor tested me for Celiac disease which came back as negative. I see here that you say to avoid gluten, and I’m just wondering how MTHFR effects the body’s ability to process gluten.

    I also was told that the average Vitamin D levels were between 70-80 units, and my test came back as 7 units, so I’m taking Vitamin D3 5,000-iu now. My lab tests came back saying that I was on the borderline of having hypothyroidism and elevated homocysteine. I got a prescription to be retested, and I saw your page on homocysteine, but I’m wondering how I should prepare differently for thyroid testing. I really would like to know one way or the other about both of these, and get them treated if there is even a chance that it could make me feel better.

    I see that you’re very busy with lots of comments, so I hope you have the time to respond to me, but I totally understand if you can’t – I just have so many questions and it’s nearly impossible to get ahold of my endocrinologist for any decent amount of time.

  160. Linda June 13, 2014 at 1:25 pm # Reply

    Thank you for providing this most valuable information. My daughter is suffering greatly from this condition and has not been able to get help from doctors in our area. She reads everything she can find on this condition especially the articles you write. She already does some of the things you listed and will immediately start doing many of the others. You are helping so many people by offering your information and products. Thank you, thank you, thank you!!

  161. Tammy June 14, 2014 at 6:58 pm # Reply

    Hi Dr. Ben, I would like to try your Optimal Multi-Vitamin because I am homozygous c677t along with a bunch of other mutation of course. I have an IgG reaction to Bromelain and Garlic based on Elisa Testing both of which are listed in the ingredients. Since these are not an IgE allergy do you think it would be ok for me to take the Optimal Multi anyway?

  162. Marcia Hempel June 19, 2014 at 11:05 pm # Reply

    I wanted to thank you, Dr. Lynch. This website and your videos and podcasts have helped me and my naturopath to straighten out my supplements and get my health in much better shape. I’m heterozygous 677 and have been taking the wrong amounts of methyl vitamins for years. Your advice and knowledge and down to earth style have helped. Now I’m waiting for the results from 23 and me.

    • Dr Lynch June 20, 2014 at 4:30 pm # Reply

      Great to hear, Marcia :) Thank you for sharing.

      • bri June 21, 2014 at 2:20 am # Reply

        Hi Dr. Ben,
        I have one copy of each 677 and 1298. I’ve had four miscarriages. I believe I’m pregnant now — only 7dpo, but a lot of signs. I’m taking your prenatal powder — 1 to 2 scoops per day, coq10 -4 capsules per day, plus the dha-, I take the L-5mthf on the days i only take one scoop of the prenatal. Do you recommend anything else to help sustain this pregnancy. Thank you for any insight.

    • David Cairns June 21, 2014 at 4:26 am # Reply

      Hi Marcia,

      Would you be able to tell us the ‘amounts of methyl vitamins’ you were previously taking compared to what you are taking now?

      Many thanks,

      • Marcia Hempel June 21, 2014 at 10:57 am # Reply

        Hi David, thanks for your interest. Years ago, in my experimentation with vitamins, I had started taking B12, and since I do a lot of research always, into my supplements, I eventually started ordering methyl B12 because I had read it was better absorbed. One day I took 5 and felt so incredibly better that it was like night and day. It was some time before I started taking folinic acid, but again I had read that the folate form was better than the folic acid form. This all was before I knew anything about MTHFR. My testing for that was very recent, and now I know so much more than I did before. (I’m heterozygous 677, and I’m waiting for the results of the 23 and me test).

        It’s kind of embarrassing to admit the quantities of B12 that wound up working for me, but my theory is that the B12 was masking my folate deficiency. I don’t really understand the way these things interact. But here is what I’m taking now: three Thorne Stress B complex a day, which has 100 mcg of B12 and 200 mcg of the 5-methyl folate. I’m taking some additional methylfolate in the 5-methyl form, and am still working on the amounts. I take about 4 a day at 400 mcg each (Jarrow), and I also still take folinic acid, about 4 a day at 800 mcg each. The methyl B12 I take in 5000 mcg capsules, and now I’m taking three a day. So now that you know what I’m taking currently for the methyl vitamins, I’ll tell you what I used to take. You have to realize that I’ve also been working very hard on my digestive problems that have been affecting my absorption, and I’ve made really good progress with that. Ok, so here goes: I used to take 8 folinic acid a day (@800 mcg), and 24 methyl B12 a day (@5000 mcg). Every time I took my vitamins (4 times a day) I would have to take 6 methyl B12, @5000 mcg. (That’s not a typo!) Every time I tried to cut it down, I would get a very sore tongue, and my fatigue would be worse. Then I started experimenting with the folinic acid, and that got up to as many as 30 pills a day of the 800 mcg pills. But it leveled the interaction between the two, I think, because I felt better, and I was able to back off on the B12 somewhat. And now that I understand overmethylation, I’m doing much better on my amounts. I really appreciated Dr. Lynch’s advice about waiting, if you feel ok!

        I now understand that some of my symptoms were overmethylation (I feel embarrassed to say!; like “duh”), and the other part of this puzzle seems to be zinc and B6 (P-5-P). I’m still adjusting things, but I have Solgar 50 mcg P-5-P pills and I’m taking it throughout the day, usually 2 at a time, and the difference is really astounding. From what I’ve read, some people’s bodies don’t hold onto their zinc and B6 very well, and it goes through them quickly, especially if they drink a lot of water. Zinc is another thing that I’ve been taking a lot of through the years, and I had B6 in my B complex before, but it wasn’t P-5-P, and it wasn’t very much. So this part of the puzzle has me very, very happy. Since starting the extra P-5-P (and I’m also experimenting with taking zinc citrate instead of zinc methionine), these are the things that are improving: my anxiety, my irritability, my energy level, my eyesight, my sleep, my concentration, my brain fog. As you can tell, I’m a person who takes a lot of supplements, and I also take fish oil, evening primrose oil, cod liver oil, vitamin A, E, D and C, chromium and vanadium, calcium and magnesium, selenium, probiotics (as bifidus), acetyl-carnitine, CO Q 10, choline, and every time I eat I take between 10 and 15 Doctor’s Best Betaine HCl. Lots of betaine.The Betaine is absolutely critical for me. My digestion really depends on it. I do not eat any grains at all, or carbs, or dairy, or sugar. I’ve been gluten free for quite a few years now. I have to be careful about the amount of fructose I eat. Right now I’m happy to say I’ve been eating spinach, and romaine, and kale regularly(thanks to Dr, Lynch’s advice and my better digestion) and I can even eat one strawberry a day (that’s a big treat for me; as I said, my digestion is so sensitive.) Carbs and dairy make me dizzy. It’s probably leaky gut. I also use quite a bit of l-glutamine for my stomach, and a little creatine. I used to eat a lot of nuts, but the phytates seem to affect my digestion negatively, so I only eat them occasionally now.

        I could go on, but I guess that’s enough for now! It’s kind of lonely doing this. I have had a couple of good naturopaths helping me, but really I’ve been on my own mostly. It’s nice to talk about it. The information Dr. Lynch has given, and all of you here, has helped a lot. Thanks. And thanks for reading all this!

        • Marcia Hempel June 21, 2014 at 11:34 am # Reply

          I also take taurine.

        • Jill July 1, 2014 at 4:33 am # Reply

          Thank you so much for your detailed information. I have a question. Did you originally start with methylcobalamin (B12) to see how it worked and then add in the methyl folate? Dr Lynch’s article says to do that but I know it’s an older protocol and not sure what changes might have been made. I’m homozygous for both COMT and MTHFR 677. I was working with a couple of practitioners. In the end I was on about 25 supplements and feeling worse everyday. A couple weeks ago I stopped everything. Slowly I’m adding things back in. Right now I’m on a basic multi vitamin from Xymogen. With that I’m taking selenium (I have hashimoto’s also). I took SAMe and MethylAssist from Pure Encapsulations but I stopped today as one of them was not making me feel good.

          I’m going to go on NuMedica’s gut healing protocol. Though I’ve been gluten free for 7 years and grain free a couple of years I never did anything to heal the damage. So I’m starting that as soon as I get it.

          I’m just curious if in the beginning you added in the methylcobalamin separately and later the methylfolate.

          Thank you so much!

  163. Tammy June 22, 2014 at 4:13 pm # Reply

    Dr. Ben,
    My son (he’s 28) was just diagnosed-he’s heterozygous for both C677T and A1298C mutations. He’s battled with depression for years and is also now suffering from body pains. I’ve read your articles but this is new to be and very confusing. What supplements do you recommend he start with?
    P.s. Thank you for all the information you have provided on your website.

  164. gloria June 25, 2014 at 10:57 pm # Reply

    Hi Dr Ben,
    I also have pyroluria, as well as mthfr… I must avoid copper in supplements. Does this ‘optimal multivitamin’ contain copper?
    I’m having trouble finding a multi without it. I don’t know why, as pyro and mthfr often go hand in hand.
    I have 2copies of 677, and one of 1298.

    I can’t begin to say how sick I am of pfaffing with food! I have zero interest in food and hate cooking. I am so weary of it all, but persevere. I can’t be the only one who is having trouble finding supplements to bolster their nutrient intake because of disinterest in food.

    I take all my supplements seperately, and the bottles are taking over the house. Any multis that you are aware of with no copper?

    • Kristin735 September 4, 2014 at 12:28 pm # Reply

      Not sure if anyone got back to you on this. I have found copper free multivitamins in my research from both Seeking Health (Children’s Optimal) and Pure Encapsulations (several from of their Nutrient 950 line). Both brands contain the 2 forms of B6 recommended for pyroluria as well as methylfolate and methylB12. The Seeking Health one also has adenosylB12. Hope that helps.

      I’d be interested in any info you have linking pyroluria and MTHFR. Can you provide links for any pages you found useful?

  165. Jill July 1, 2014 at 4:13 am # Reply

    Does anyone know how Dr Lynch’s protocol has changed since he first posted this? Does he still believe one should introduce methylcobalamin before methylfolate? Any help would be appreciated.

    I’m homozygous for both COMT and MTHFR C677.

    Thank you!

    • David Cairns July 4, 2014 at 3:55 am # Reply

      Hi Jill,

      I also posted the same question a few weeks back but unfortunately I never heard anything.

      My understanding was that by introducing these separately you would avoid methyl trapping.

      However there is definitely a Dr Ben Lynch video on YouTube where he says that he needs to revise his protocol as he now suggests to take them together. I think the video that mentions this also features Ameer Rosic (but I could be wrong on that as there are 6 Dr Ben videos that I know of totaling about 9hrs!).

      If you do find out then please do let us all know as I am currently working on improving my gut, diet and liver and then finally I will once again try the B12 and Folate)


      • Jill July 4, 2014 at 4:15 am # Reply


        Hi. I actually saw your post. I thought I’d try it myself to ask again. I wish we knew which video to look at. I was wanting to watch one of his videos where you had to pay to watch. It was $350 for a practitioner, and $150 for others. That’s not an option for me.

        I’ll tell you where I am at. I am seeing a functional nutritionist who is extremely knowledgeable and has healed herself of almost exactly the same things that I have. Though she can order functional tests, she had me see a functional MD so he could order further tests. They are very much in line about how to deal with all of this…and everything that I was taking (supplements) was on Lynch’s protocol. I had some different ones also, but much the same.

        What happened was that the more supplements I was adding, the worse I felt. Until the point where I felt so toxic, and had so much body ache in my neck, back and shoulders, and strange headaches that I stopped everything. Within a day or two I felt much better.

        Now working with my functional nutritionist, she’s told me which supps are critical to get back on first. I am now introducing a new supplement every two days. If I feel ok, I add another one.

        A piece of the puzzle that I think was missing is that I have to heal my gut first. I’ve been gluten free for 8 years and grain free for about 2 years…but I never repaired or replenished my gut. And since about 80% of our immunity lies in our gut…I think it’s a big factor. I’ve ordered NuMedica’s gut repair program. I’ve researched this a lot and feel good about starting this. I was at the Institute of Functional Medicines conference in Feb and spoke at length to one of their nutritional consultants. If you’re interested it’s NuMedica’s Gluten Sensitivity Support line. It has some amazing products in it. I also ordered methylcobalamin lozenges from them. I’ll start those after i get my gut underway.

        I can’t tell you how much better I feel since I stopped everything and am now just adding things in slowly.

        There’s more info I can give you if you’d like to connect with email. Don’t want to go on and on here.

        • David Cairns July 4, 2014 at 6:40 am # Reply

          Hi Jill,

          Please do keep us updated on how you progress and any ‘must haves’ that you discover. I expect there hundreds if not thousands of people in the same boat.

          There are a lot of similarities between your path and my own. As soon as I learned that I had C677T I looked at the protocol, ordered everything and started. After 5 days I stopped as the pounding 24hr headaches were no longer bearable. Since then after watching videos by Dr Ben, Neil Rawlins and Richard van Konynenburg I have a much better understanding of how the gut is linked to all of this.

          I have also come across the ‘toxic overload’ of taking too many supplements (even though they are recommended). Even today I have just had to cut out the 4 most recent ones and I will try reintroducing them.

          I have tried many things over the past 4 years and have also been prescribed the most dreadful things (Epilepsy tablets and Anti-depressants), I was even told I had ‘Mad Cow’s Disease’ (CJD).

          Some things have helped but as you say you need to introduce things slowly and one at at time. But every now and then I slip up and have to back track. Usually with a bad headache

          The best result I have had in the last 4 years (although not perfect) is too begin a Candida / SCM type diet. One thought my ND had is that I have systemic Candida. So I have cut ALL sugars (even fruit), grains, dairy, pork, and starchy veg. I can tell you it has been tough….and boring, but until 3 days ago when I added some simple supplement and vitamins into my regime, things had been looking much better. I pretty much went for 3 week straight with no brain fog, confusion or loss of balance. SO there is absolutely a link to diet.

          p.s I will take a look at the NuMedica’s Gluten Sensitivity Support and also send you and email


        • David Cairns July 4, 2014 at 8:03 am # Reply

          Hi Jill,

          I thought it would take ages to look through all my MTHFR videos but as luck has it I found it in the first 5 minutes.

          The YouTube video you want is
          “MTHFR and Methylation Advancements_ Q and A with Dr Lynch”
          Uploaded on 17 Jul 2013

          Go to 14:35

          Quote “I would be utilizing both at the same time”

          In a slightly earlier video dated ’12 Apr 2013′ Dr Lynch talks about taking B12 first

          “Folate Metabolism and MTHFR: An Introduction ”

          (A great video by the way)


      • Jill September 4, 2014 at 12:44 pm # Reply


        I thought I’d let you know that I think I found a very good protocol for healing the gut. I’ve been on it a couple of months, going into my third and can definitely tell the difference. Also, though I rarely if ever eat corn, as it used to give me headaches, a couple weeks ago my kids had some non GMO popcorn. I have to say I ate quite a bit for a couple of days consecutively and I never got a headache. I believe this is because my gut is healing and can handle the foods it once couldn’t. That being said, I won’t eat corn anyway.

        The product line is from NuMedica and it’s called their Gluten Sensitivity line.

        If you decide to take it please let me know how you’re doing.

        As for the other info, I am now working with an amazing naturopath who went to the methylation conference last year. Everyone in her office did. We’re doing some more testing. I’ll let you know where we go with the supps. When I showed her my supps (27 bottles I brought into the office), I did have a bottle of sublingual B12. I do believe she said to start with that. But my multi vitamin that she likes (Nutrient 950 without iron from Pure Encapsulations) does have some of both Bs.

        Again, let me know if you decide to do the NuMedica line as I have a bit more info about how to take it.


  166. Heidi July 3, 2014 at 1:34 am # Reply

    Wow what a great website! I’m still reeling from all of the information. My ten year old daughter is homozygous for MTHFR C677T (as well as VDR Taq ,MAO-A R297R, MTRR A664A, BHMT-08, and CBSA360A). I’m heterozygous, and just trying to figure out what all of this means. My daughter has had years of pain, stomach issues, chemical sensitivities, food sensitivities, etc (as have I). Thanks for all of this information so I can try and help her more.

  167. Marcia Hempel July 4, 2014 at 11:22 am # Reply

    Hi Jill, Hi David

    When I began taking methylcobalamin, with supplements, I knew nothing about any of this, and was trying B12 out after my naturopath said it would help with cortisol problems (I thought I was having problems from stress). When I happened to take several of the 500mg supplements (later I switched to 5000 mg), I felt so much better, with much better energy, that it started me on a long road of experimentation, but unfortunately I wound up using very high quantities of methylcobalamin for quite some time, and became quite overmethylated (I now know). As for the folate, the folate that I was getting was coming from B complex pills that had folic acid in them. That was probably at least a year, but it’s hard to remember. Eventually I read about folate being better than folic acid and I switched to folinic acid, not really knowing about methylfolate at all. I took quite a bit of folinic acid, for quite a long time and recently had increased the amount of folinic acid to very high amounts (and that was helping with the overmethylation somewhat, because I was taking too much methylcobalamin, and it was more in balance). Then I had myself tested for MTHFR, and learned more about the use of these supplements. I started experimenting, and added methylfolate into my supplements, backed off on the folinic acid, and backed off on the methylcobalamin.
    My overmethylation symptoms generally come up as irritability, but if I don’t take enough methylcobalamin and methylfolate, I really can’t think. In my experimentation recently, I tried completely stopping the methylcobalamin (well, almost), and cutting way, way back on the folate, and all of a sudden I couldn’t remember my ATM card PIN. I changed it! Had to go down to the bank, I never did remember it. My poor brain is so sensitive. I think I really need the methylcobalamin to think. My brain fog and dizziness can be a constant companion sometime, and all day long I struggle with it, and take my supplements partially guided by it, as the day goes on.
    I have been having good success with the recommendations I’ve read about, concerning pyroluria. The two important supplements for it are zinc and B6. If I take zinc citrate and B6 (regular B6 not P5P), periodically through the day when I feel the brain fog and dizziness, it seems to help. I also take P5P with the supplements that I take with food, and zinc, too, so in the end I’m taking quite a bit of zinc and B6. But according to what I’ve read, some people just can’t seem to hold on to these two vitamins in their bodies, they get bound up by pyrrholls (I forget how to spell that) and are excreted all the time. The warnings about taking too much zinc or taking too much B6 I just have to use my own judgment about, If I’m dizzy and this is helping, and I can’t find another solution, then this is what I’m going to do! If I’m a person who excretes it all the time, I don’t think it’s going to cause me terrible problems. The way it feels is that I’m going to have problems if I don’t take it. My anxiety level has decreased since I started taking the zinc and B6 during the day. Anxiety is another symptom of pyroluria.
    The l-glutamin, d-ribose and creatine help my energy level and clarity of mind, too, and so does the selenium I take. I take quite a bit of magnesium malate, and calcium. I’m taking some B2 now, also (extra- I take a B complex a few times a day, and that has small quantities of the B vitamins).
    I have a lot of trouble with fructose malabsorption, and cannot eat dairy or gluten or really any carbs. Lately, though, I’ve been able to eat a couple of strawberries every day, and that’s a big improvement for me. Everybody likes to have some kind of treat! I’ve been eating a lot of liver, since Whole Foods came to town and I can buy good quality liver. It’s recommended in the GAPS diet. The Bifidus probiotics that I’ve been taking are good for my stomach, and the betaine HCl I take is absolutely necessary for me, my stomach acid is very, very low.
    I love to have people to talk to about all this. I spend a lot of time and effort (and money!) thinking and reading and experimenting. I take my B complex, which has methylcobalamin and methylfolate, I take two or three or four methylfolate a day, and about three methylcobalamin in a 5000 mcg dosage. I can’t take lozenges, because every single one of them has xylitol or some other kind of sweetener, and my sensitivity to those types of sugars is not good.
    Some of the MTHFR supplements like glutathione I cannot take, I think because I’m an overmethylator.

    • Jill July 4, 2014 at 1:36 pm # Reply

      Thank you Marcia for sharing your info.

  168. Rosanne July 8, 2014 at 2:27 am # Reply

    Hi Dr. Lynch,

    Thank you for all the great work you are doing and information you are providing. I am homozygous for the C 677T allele and follow your basic protocol with some tweaking. I am postmenapausal and have been getting estrogen and testosterone slow release pellets implanted for 8 yrs now. I also take bio identical, compounded progesterone nightly. When you say no birth control or oral hormone estrogen you mean because they are processed through the stomach and liver right? Is it ok to continue taking them the way I do? I actually feel terrible when I’ve tried to stop as menapausal symptoms return. Thanks for any insight you can offer.

  169. Mary July 14, 2014 at 5:44 am # Reply

    Hello :)
    I recently found out that both alleles of the mthfr gene show the c677t mutation, indicating that I’m homozygous. I also have RA and was on methotrexate for 6 months. The doctors immediately took me off the methotrexate with my new diagnosis. Would you recommend that I get tested for blood clots? Is there anything else you would recommended? They now have me on 2mg of folic acid, baby aspirin, hydroxychloroquine, vitamin D for my vitamin d deficiency, and soon a new ra medicine. I also take birth controll pills Gildess.
    Thank you…. M.G

  170. Olivia July 15, 2014 at 6:26 pm # Reply

    Hello Dr Ben,
    I am in desperate need of help, a little about me first.

    I am compound heterozygous C677T and A1298C. I had a spontaneous placental abruption a few years ago at 6 months of pregnancy and lost a perfectly healthy son. I had an amnio, etc… I had another son just 2 years previous to the one I lost who is healthy and thriving. With my live and healthy son I was following my own supplement regimen based on how I felt, which I only found out later happens to be almost identical to what you recommend during pregnancy. With my second son who I lost at 6 months of pregnancy (I still had never heard of MTHFR at that point) I took a synthetic prenatal because my doctor aggressively convinced me to do so. She said my own regimen of vitamins and minerals bordered on child abuse and that I was only lucky the first time with my first son, that he wasn’t born with a major birth defect. I don’t know how I allowed myself to be convinced this doctor knew my body better than I did. This same doctor also told me MTHFR was not a “real” diagnosis of anything and it means nothing but I won’t go there… Now we are desperately trying for another child and time is of the essence because of my age.

    My only chronic health issue I’m treated for is idiopathic hypothyroidism. On paper I look fine but was never able to conceive and/or carry to term and I had terrible symptoms. When I started taking natural replacement I was able to conceive and carry to term. My TSH is .01 which is very low but “normal” for me and where it was with the birth of my live and healthy son. I can tell if it’s off, I get many terrible symptoms back almost immediately. I take 3gr of natural porcine derived Canadian Thyroid (Erfa) a day, yes, we order it from Canada. I am overweight partially from my thyroid and partially from the fertility treatments which have been very hard on me physically.

    I also have been tested and found to have activated NK cells (autoimmune issue) in the uterus which will almost always cause me to miscarry. I’ve had over 25 miscarriages. Somehow I was able to overcome this by myself with my first son, on my own supplement regimen. Now when I conceive again I need steroids and intralipids to overcome this issue. I have a different doctor of course. Interestingly this doctor told me he sees this commonly with patients that have MTHFR and especially those with hypothyroidism. He also said most of his patients with hypothyroidism subclinical or otherwise, also have MTHFR. He says eventually I will develop thyroid antibodies and I should watch for it in the future, I have none at this time.

    Our lifestyle:
    All organic diet
    Free of gluten, pasteurized dairy, soy, and very little corn
    Very little processed foods, maybe cereal for a treat or frozen ice
    95% home cooked from scratch we grow most of our own fruits and veggies
    Organic free range eggs, we now have chickens
    Raw organic grass fed milk and yogurt I make
    Organic grass fed meats
    Fermented foods I grow and make myself
    Canned foods I grow and can myself in glass
    No plastic
    We avoid as many chemicals as possible in our home and for personal care products
    Supplements as you recommend

    Here is my problem. I have recently realized I’m having a problem with P5P. Strangely I don’t remember having this problem before. In fact I’m sure I didn’t for some time. I took it daily. Now I can’t even take it once a month. It causes my hands to crack and bleed. I think my hands even swell a little. My joints don’t hurt but the cracking and bleeding does. This requires a week or more of Neosporin cream on my hands for it to heal. It makes life difficult because I cook so much and I’m a stay at home mom. This is my only symptom. I haven’t taken it for months now. I’ve never had anything like this before. I’ve even tried different brands.

    Does this mean I already have too much B6 in my body? Should I just avoid it completely? Why would this just start to happen? Can I take B9 and B12 without it? Should I just take my supplements separately and skip it? I don’t know how this affects the management of my MTHFR and overall health. Perhaps it’s a detox reaction and I need chelation?

    Please help me, I have little time left to have another child because of my age. We are all self pay and money is running out. I have spent the last 8 weeks researching this but this time I am unable to find anything anywhere. I have read about peripheral neuropathy but I don’t think that’s what it is, I have no pain at all, absolutely no numbness, heavy feeling, glove feeling, tingling, dropping things, etc….not even one symptom. I do have very very slight tingling on the ball of my left foot but that was always there for many years, before and after, and it’s very very little. I very rarely notice it. I’m sure it’s not related to the P5P reaction. When I stop P5P all symptoms go away. Please help me. Thank you for reading my situation.


  171. Patricia W., PhD July 16, 2014 at 10:51 am # Reply

    Hi Dr. Ben,

    I just got my report back from Seeking Health. I have MTHFR 677C>T TT.

    Can you briefly explain with the various “T” s mean. Is it that I have one 677c T mutation and one 677c TT (double T) mutation? Is methylfolate still in order? I thought I read that methylfolate only helps if you have one kind of “T” situation, but not the other…

    Thanks for clarification.

    Patricia W, PhD

    • Lynn_M July 16, 2014 at 5:18 pm # Reply

      The TT is your particular test result and it means you have the double mutation of C677TT. The 677C>T is one way of showing that C is the wild allele and that it can get mutated to T. It is equivalent to saying C677T.

      Yes, methylfolate and all the other supplements specified in the basic prototol are in order for you. Methylfolate is helpful for both heterozygous C677CT and homozygous C677TT situations.

  172. Eter P. July 18, 2014 at 7:26 am # Reply

    Dear. Doctor,

    I am 40 with 2 young kids. I live in Phoenix, AZ area. I am hetero C677T and normal 1298, and I have not been tested yet for any other gene mutation tests. I also have 10 times more than normal anti-TPO antibodies that makes me a Hashimoto patient.

    I have 4 questions, please:

    1. What any other DNA mutation tests should I go through? and what lab is a good one to use.

    2. Should I do a food sensitivity or/and metal tixicity test through US Biotek or Cyrex labs?

    3. Using a Ph urine stips, I am very acidic, so, how should I decrease my Ph?

    4. I have never done any detoxification, what would be the best way to get rid of any or all kids of toxins?

    Thank you for your time and help

  173. Sylvia July 19, 2014 at 3:52 am # Reply

    What protocol would you recommend for a child that is not quite 2 years old?

  174. Donna Harper July 24, 2014 at 1:24 am # Reply

    Greetings Dr. Ben,
    I wonder if you could answer some questions for me?
    I recently discovered through some testing prescribed by Mary Schrick ND at the Full Circle Health Clinic in Edmond Oklahoma, that I have the heterozygous genotype for MTHFR C677T (C/T) and MTHFR A1298C (A/C) polymorphisms.

    What exactly does this mean please?

    I was given Starr Walker Methyl Support. It contains the following:
    * Riboflavin 25 mg as riboflavin 5′-phosphate sodium
    * Vitamin B6 10mg as pyridoxal 5′- phosphate
    * Folate 2000mcg (1000 mcg as calcium folinate and 1000mcg as 6(s) methyltetrahydrofolic acid, glucosamine salt)
    * Vitamin B12 1000mcg as methylcobalmin
    * Betaine Anhydrous (trimethylglycine) 500mg
    I take two a day
    Is this a good formula?
    Thank you for you help

  175. Tiffany July 24, 2014 at 7:54 pm # Reply

    I am homozygous C677T. I know I have other genetic abnormalities regarding clotting factors, but I couldn’t tell you what they are without my paperwork. I was tested for MTHFR by my neurologist after my mother had a massive blood clot to her Superior Mesenteric Artery, causing short bowel syndrome. I also have PCOS and insulin resistance, migraines, and syncopal episodes or “fainting goat syndrome,” as my neuro put it. I’ve known all this for almost 10 years, some of it longer, but I only recently found your site when I renewed my research efforts due to the possible banning of folate over the counter. I no longer see my neurologist due to insurance changes over the years. It’s been over 5 years, in fact, since I’ve had proper insurance to allow me to get back into my routine testing for these various factors, and I have only found a primary care physician in the last couple of years. I intend to educate myself some and present both my doctor and my sons’ pediatrician with information to help us get properly monitored and maintained. Since I know about my faulty genes already, I don’t have to convince anyone for genetic testing (except the ped, maybe), but otherwise, where do I begin when speaking to my doctor about these things? Also, in going over your protocol, I wondered what are the reasons behind going gluten and dairy free? I want to make sure my kids get an early start in being healthy, and so far we haven’t gotten off so great. They are 6 and 2 years old. My toddler is a great eater and will eat anything (almost) that I offer him and eat myself. My 6 year old is incredibly picky to the point that I’ve made the decision to ask his pediatrician about malnourishment. What he will eat, he usually only eats a few bites of and begs to be done. Milk and peanut butter have become his staples so that I know he’s getting calcium, protein, and calories, but I know he has to be lacking in so many other areas. What suggestions do you have? Thanks!

  176. Barb Stock August 7, 2014 at 11:36 pm # Reply

    Hi Dr. Ben You are truly an answer to my prayers. I have recently been tested for Mthfr and have found that I have one copy of the 677 and 1298. I guess this maybe explains why I had migraines at a very early age, I have had 3 one at age 26 strokes and now had a coronary by pass. I have tried to eat healthy and at one point I was a vegitarian, I cannot take any kind of medication at all without it putting me in bed. I have constant pain in or behind my eyes everytime I eat anything, I am gluten free, I take probiotics and juice regularly . I realize that I need to detox but I get very very sick I dont even juice spinich as I find it gives me pain in the eye, Im guessing that the iron is to great for me, I quit taking b’s sublinqual as I suffered with terrible migraines. In all of the things that I think Im doing right ends up Im making myself worse. I have talked to my neurologist but he isnt familiar , At this point I dont know where to go,,..,Can you give me any idea of what my first step is I am already trying to detox and clear the gut, of any parasites as well., thanks I appreciate your help

  177. Marie August 9, 2014 at 3:11 pm # Reply


    Is anyone else homozygous for all three CBS mutations? I have not been able to find anyone else with the same genes or any protocols to follow if you are homozygous for all 3. I am also homozygous for MTHFR C677T. Thank you in advance!

  178. Jane August 12, 2014 at 11:22 pm # Reply

    Dr Ben, My daughter is 24. She is homo VDR taq, hetero Mao ar297r, math for c677t, mtrra66g, mtrra664a, bhmt 08, and cbs a360a NO call. She suffers terribly from CFS, depression…low basil temp, and anemia. Can you recommend how to start off? She is struggling being a new grad Dr of PT. HELP PLEASE. Jane

  179. Tammy August 17, 2014 at 7:19 pm # Reply

    Dr. Lynch, I tested heterozygous for both C677T and A1298C. What supplements do you recommend? My doc suggested Vessel Care but I read somewhere on your website you don’t recommend it. Thank you!

  180. Sonia August 26, 2014 at 3:36 am # Reply

    Hi Dr. Ben!

    You mentioned in your article “Cook with electric stove and oven and remove gas stove and oven.” Could you explain your thoughts on that?

    Thanks so much!

    • Dr Lynch August 26, 2014 at 6:43 am # Reply

      Gas is a toxin which belongs outside – no matter how efficient your cooktop is, it still is making fossil fuels into your home and your body.

  181. Denise August 27, 2014 at 7:28 pm # Reply

    Hi dr. Ben,

    I just found out that I have MTHFR. C677T heterozygous on ONE allele. Not sure what it all means and what to do.

    I’m type 1 diabetic, have asthma, fibromyalgia, arthritis and thyroidectomy from papillary cancer. I feel tired all the time, can’t focus, and have pain.

    I asked for this test, and the adrenal, cortisol, DHEA test. Which came up very low on all three.


  182. Jessica August 28, 2014 at 7:08 pm # Reply

    Hell Dr. Lynch,

    First a tremendous THANK YOU for your research and dedication. I can relate to so many of the stories I read on your site and for once I feel as though I’m not crazy. I’ve been battling with poor health, infertility, and anxiety for many years. I’ve been worked up for Lymes, and thyroid. I have poor egg quality, uterine polyps, and endometriosis. I’ve insisted for years that there is an underlying cause and I’ve been told time and again ‘it’s in your head, you’re fine.’ Countless members of my family have struggled with anxiety and depression, and 2 of my young relatives are on the autism spectrum.

    Several months ago I visited a nutritionist. The blood work he ordered uncovered a homozygous C677T mutation. My nutritionist started me on Homocysteine Supreme (B-2 50 mg, B-6 50 mg, Folate 2400 mcg, b-12 100 mcg Mag 10 mg).

    I would like to begin your protocol while on the hunt for a practitioner that is knowledgeable about this condition. My question is – Knowing that I have been tolerating the Homocystine Supreme and have noticed little improvement in my anxiety and general well being, which of your recommended methylfolate combinations do you suggest I start with? And do I take this in addition to the multivitamin formulation in Part I?

    I also plan to include the other aspects of Part I such as the Proboiotics, krill oil and Vit E.

    I hope and pray that this discovery will help improve not only my health, but the health of my family and our future generations. I was brought to tears when I read your comment about knowing if you or a loved one has a MTHFR mutation is a blessing because now I can do something about it. Without options I felt helpless. Thank you for giving me options and restoring my hope. Please keep up the amazing work you do!! Our society is in desperate need of pioneers like yourself.



  183. Chelsea August 29, 2014 at 4:55 pm # Reply

    Hi Dr. Ben,

    First a little backstory:
    I was diagnosed with the homozygous mthfr when I became pregnant with my son in 2011. The doctors wanted to check my blood because I had a miscarriage at 19 weeks in 2007. I carried my daughter to full term in 2005, but had preeclampsia with her and severe hypertension and ended up having an emergency C-section. So, having that history, when I became pregnant with my son in 2011, they tested me and found that I have both copies. I was put on baby aspirin, vitamin d, fish oil, and you guessed it, folic acid. I carried him to term and everything was grand. Only thing was, I got conflicting information from my obgyn and the specialist that delivered my son. One said, take folic acid everyday and you’re fine, the other said, I don’t think you need anything but a baby aspirin. So it got me researching…and lead me to you.

    And now my question:
    I saw an alternative doc last year and he said I should take Metagenics Phyto-Multi with iron, are you familiar with that? it has the right forms of b12 (200 mcg) and methylfolate (800 mcg) that you recommend. I only take one a day though, instead of two, because quite frankly I’m nervous about the iron in it. I guess that means I’m only actually getting 100 mcg of b12 and 400 mcg of the methylfolate. He had me start on liquid methylcobalamin first, 1000 mcg a day for a week, and then start on the multi-vitamin. Do you think this is enough? I think the b12 makes me a feel a little flushed and I have anxiety/panic problems anyway but it triggers them. Why does that happen? Should I continue taking the liquid while taking the multi? that would be a lot of B12, I’m always afraid of overdosing on things. He also recommended that I take cod liver oil, I haven’t heard you talk about that and was curious as to what your opinion on that is. Thank you so much for your dedication to all of us out here wondering what to do! Reading your website finally gives me answers to symptoms I’ve battled with my whole life, and now I don’t feel as crazy! Thank you , Thank you!


  184. laura August 31, 2014 at 10:06 pm # Reply


    I was tested recently and am heterozygous for the C677T polymorphisim in the MTHFR gene. My test also showed theat I have CYP2D6 gene deletion. I’ve taken 20mg of Lexapro for several years. Do the the CYP2D6 gene deletion, I am a poor metabolizer of Lexapro. (My test showed I should probably take lower doses of Lexapro and my genotype may impact drug mechanism of action and result in reduced efficacy.

    My doctor had me reduce my Lexapro to 10mg (1 week at 15mg then down to 10mg). And, prescribed 15mg Methylfolate (she did not have me slowly increase it, I started on 15mg).

    Two and half weeks in, I feel horrible…insomnia, I get tired and out of breath very easily, very dizzy, headaches, foggy, increased anxiety and just feel off.

    Any advice?

  185. Caylee-jo September 1, 2014 at 6:47 am # Reply

    I am new to this site as well as the whole mthfr stuff. I just have a few questions to ask about this. But first, a bit of a backstory. I’m a 24 year old female, married for 7 years with two precious miracle boy’s. I say miracle because before I had my first son, I suffered 9 miscarriages. Each time I would get a little farther and lose the pregnancy. After several surgeries, 8 to be exact, I was diagnosed with severe endometriosis and found out that I have A- blood and would need RhoGam shots. We thought that this was the problem with my body and that I was fix! My OB put me on the LeupronDepo shot. I was miserable due to the side effects and was sure that my husband would kill me. We ended up moving across the country and I had my last shot at the end ofApril 2009. My cycle was never a problem. I was regular like a clock! I then found out that I was pregnant July 4th, 2009! I had no idea that this could happen! I found an OB and was seen every week for an ultrasound. We did nothing to try and prevent the potential loss. I began to believe that there was no way to prevent it. My pregnancy was just marvellous! My son was born May 4th, 2010. He was born 5 week’s late, but he was perfectly normal, healthy and wonderful! He weighed 9lbs 10oz and was 22inches long. He scored all 10’s on the APGAR ratings. We moved across the country again and was seeing a wonderful physician! When my husband and I decided to try for another child in June 2011, we went to the doctor to make sure that I was okay to try again. He gave us the go-ahead, but warned that it may or may not happen, given my history. I called him back a week later and told him I was pregnant! He couldn’t believe it! I saw him and he confirmed it. He started me on progesterone suppositories until I was 30 week’s along. Again, this pregnancy was just blissful! My son was born on time, on March 2nd, 2012. My boys are 22 months, 2 day’s, 2 hours and 22 minutes apart! Talk about unbelievable! He was born happy and healthy just as well as my first. However, he needed to have a chordee repair with a circumcision. I later found out that the progesterone causes this birth defect. But, other than that, he was perfect! I had trouble with myself after the pregnancy. I wouldn’t stop bleeding! I had a D&C, was on estrogens then progesterone, back and forth for the first year postpartum. I had to be careful because I was exclusively breastfeeding at the time. I then started to see a reproductive endocrinologist and he did several tests and found out that I also have adnemyosis by doing a hysteroscopie and obtaining a sample of my uterus. He then had me see a hematologist for some blood work. The results came back as me having VonWilibrans factor 5 and as they said, “both factors of the MTHFR mutations”. I was told that they couldn’t treat me as some how these two things balance each other out?! I was told to avoid anything that would thin my blood, NSAIDS, vitamin e, etc but to take 1200mg of b12 sublingually twice a day and to increase how much I take of folic acid a day as well. So, that’s what I have been doing. The doctor said that the estrogen was causing my bleeding on top of the clotting disorders and ordered to never be on estrogen. I bled for the first 18 months nonstop! I then stopped in October 2013. But it only stopped for a month and then it continued. We moved to another state, December 2013 and found a new OB for my care. I was told that I have two options, have a full hysterectomy or try the nexplanon birth control. I chose the latter as I can’t take estrogen and I am still far too young for that. We agreed and I had it inserted in March 2014. I have been bleeding now for six months yet again! I stopped for a week on the week before the implant was placed and it won’t stop! Just this past June, he did a laparoscopy to remove all of the adhesions and tissue growth. He ended up removing my left fallopian tube as it was just a tangled mess! I have never had such a horrible time with my menses. I have been regular since the age of 8. So, I guess I’m just trying to figure this all out since this is so confusing! I’m contemplating on having the implant removed but would like to know what I can do to regulate myself once again first. I’m so tired of being tired, weak and in pain from the constant bleeding.
    So, in a summary, I have rH- factor, vonwilibrans factor 5 and both of the MTHFR gene mutations. What can I do to make myself better? I seem to be able to only find information about this and it contradicts everything else I’ve read or have been told. Also, could any or all of this have caused my miscarriages?
    I’m sorry for writing so much and I will appreciate any and all idea’s that I can receive.
    Thank you so much!

  186. Matilda September 4, 2014 at 3:54 am # Reply

    Sorry if this has already been addressed, but I have a question about Part 2 re this: “Once you discover which methylfolate supplement you tolerate best: Active B12 with Methylfolate, HomocysteX or HomocysteX Plus, then work on adding in additional methylcobalamin via Active B12 5000.”

    So am I supposed to have the 4-6 capsules of HomocysteX Plus (or 4 capsules of HomocysteX, or 1 tablet of Active B12 with Methylfolate depending on which one I tolerate best) in addition to the 1 tablet of Active B12 5000?

    Or is it just 1 of the Active B12 with Methylfolate, HomocysteX or HomocysteX Plus with the Active B12 5000?

    Thanks :)

  187. Nicole September 11, 2014 at 5:02 pm # Reply

    Dr. Ben,

    I found out earlier this month that I’m homozygous for the MTHFR C677T mutation. I’m trying to bring myself up to speed, and have a few questions.

    I’m generally very healthy. I’m 25, pretty physically active outside of work, and absolutely health-minded. I’ve been gluten-free (in fact, grain-free, and processed foods-free) for about three years. My normal day’s diet consists of 1-2 cups of organic coffee in the morning with some organic sugar-free coconut almond milk in it, organic raw unsalted almonds/cashews/walnuts and a piece of fruit (usually an apple or orange or some berries) for breakfast, along with my multivitamins, some sort of protein such as organic boiled eggs, grilled chicken (no salt), or sliced roast beef (also organic) on top of a leafy green salad with lots of rainbow colored vegetables for lunch (topped with organic olive oil and lemon juice), and then an early dinner, usually lightly steamed broccolli, brussels sprouts, asparagus, etc, with more proten (salmon, chicken, turkey, etc). I snack when I’m hungry throughout the day (usually carrots, celery, more nuts, or another piece of fruit), but I do practice intermittent fasting, and try not to eat past 6pm or earlier than 10am if I can help it. I’ve never smoked, done any drugs, and I barely drink. I’ll have a glass of wine, if occasion calls, but it’s pretty infrequent. I really resist taking any over the counter medications when I’m sick or injured, and avoid even tylenol, except for the occasional unbearable headache (inconsistent caffeine intake induced) or monthly menstrual cramps. Benadryl I occasionally must take (about 3-5 days per year) if I’m having an allergic reaction (severe shellfish allergy that causes anaphylaxis; I also carry an epi-pen for that as well, although I’ve never had to use it, thankfully).

    Until recently, I’ve been in grad school, so an entirely organic diet was cost-prohibitive, but when it comes to organic foods, I always buy organic meats and dairy, and I try to also buy organic fruits and vegetables when I can. I eat dark leafy greens daily. I take spoonfulls of fish oil every night before bed, and I take multivitamins (ultranutrient brand) in the mornings. I also take Galium heel homeopathic drops to improve my lymphatic function, at the recommendation of my doctor, and try to do dry body brushing once a week, sometimes twice. I use an elliptical at the gym two or three times a week, for about 30-45 minutes each time, and I do pilates. That sums up my general lifestyle/health practices.

    Anyway, now that you have some context about my diet, lifestyle, and general health, I’m wondering how I’ve lived 25 years of my life with this homozygous MTHFR C677T mutation and been healthy? I always did very well in school and extracurriculars, and have never had any major health problems (knock on wood). I never had any behavioral problems, except I would sometimes be bouncing off the walls when I had a ton of sugar (candy/soda). My mom regarded that as poison/contraband in our house growing up, so that was infrequent.

    The only thing truly peculiar about my health is that I used to get horrid hives when exposed to the cold temperatures growing up (cold urticaria). They were white, sometimes red, and welt-like, and would cover my whole body, and my eyes would even swell shut. I was an unrecognizable alien-looking person when this would happen to me. Sometimes, when it would happen, it was unrelated to the cold, and I would get large white welts all over my body without any explanation. We looked for causal connections between the episodes, and found none. The random hives perhaps seemed to increase in frequency when I started menstruating (age 13). My doctors all pointed to food allergies, hormonal changes, and perhaps stress (I was very competitive in music growing up, and would enter several high-stress competitions per year).

    I should also mention that as a kid, when anything would abruptly hit my skin (think of a dodge-ball in gym class, or a high five, or if I would be playing jump-rope and the rope would hit my legs), I’d get an instant, huge welt, that usually went away within 20 minutes. Sometimes I’d sit out from gym class when we were playing contact games. Doctors said that was a hystamine reaction, and something was off about my hystamine. I never had any sort of treatment for it, and eventualy just grew out of it. That has totally gone away since childhood, and no longer happens, but I probably experienced that for 5-10 years of my childhood, if I had to put a number on it.

    Anyway, other than the bizarre hives and contact-caused skin welts, which I have not experienced in the past several years, I’m totally healthy, and feel generally energetic, happy, and healthy. I’m fit (105 pounds, 5’4 frame), and I have no history of depression or other chronic health problems. I suppose I get pretty terrible menstrual cramps on day one of my period for a few hours right at the onset (severe pain, vomiting, paleness, light-headedness), but don’t a lot of women? Could that be related? I never had those symptoms from age 13-17 (pre birth control pills, when I actually had pretty easy periods), and only got them after I went off of birth control (20-25). They’ve gotten slightly better each year. I suspect my hormones were out of whack for awhile from the birth control. I guess I also should mention that for me, regular cycles are 34-38 days apart, rather than 28. No idea why. My gyno said I might not be ovulating due to the stress of grad school, during which I also worked close to full time. Because that doctor has always been insistent that I should go on another birth control pill, I recently switched to a new doctor who incorporates natural remedies into her practice. I’m hoping she can give me some better insight. I’ll note that she is opposed to prescribing birth control pills.

    Getting back to my inexplicable good health (since it appears from this blog that many people with the homozygous mutation have serious health problems), it may well be that my mom knew her stuff with nutrtion, and was able to avoid some of the problems I possibly would have had, had she not given me cod liver oil, zinc, D3, and sublingual B12 every day as a kid (she is VERY health oriented as well, and has done quite a lot of research, since my siblings have had much worse health problems than I, especially food allergy and behavior related). She had us all nutrition tested at a lab when we were young kids, and they compounded vitamins for us based on our deficiencies. My brother, who had pretty bad health problems, became pretty much normal once he started with the nutrient therapy. Unfortunately, they always gave me high levels of folic acid, which I know now was not the right choice. On other counts, I think they were spot on with my supplementation.

    Anyway, in terrms of what I can do going forward to increase/maintain my health and wellbeing, other than slowly switching my vitamin regime in the ways you outline above, and continuing to eat the dark leafy greens, perhaps with some increase in that regard, any suggestions for me? Since I’m healthy and feeing good, I’m hesitant to change my routine.

  188. Kelly Hodge September 12, 2014 at 3:33 am # Reply

    So Dr. Ben am I understanding you right your saying do not take 4mg of folic acid if you are trying to conceive or even once you do get pregnant? I have mthfr c677t one mutation and have just experienced my fourth miscarriage. I have one healthy little girl and was on baby aspirin and lovenox and 4 mg of folic acid with her this time that combination didn’t work…????

  189. E.D. September 23, 2014 at 7:19 am # Reply

    Is there such thing as too much folate? I’m taking 1 pill per day of Methyl Guard plus, but am considering switching to Optimal multivitamin instead. I am heterozygous for C677t.

    • Marcia September 25, 2014 at 11:34 pm # Reply

      I like to have the option of adding more folate (or taking less folate). If you take too much, sometimes people feel wound up. Then sometimes people take 50 mg of niacin (it’s called overmethylating). I take my folate and B12 separately, and then I can control the dosages. People’s needs can change from day to day.

  190. Heather wheeler September 29, 2014 at 4:38 pm # Reply

    Hello Dr Ben,
    I have been a vegetarian for 7 years and I have a mthfr blood clotting disorder. I forgot which one they are going to fax it to my children’s doctor. I have a question .. I have a 6 month girl and 2 boys connor 2 and cameron 8. What should I give them? My 2 year old had swallowing issues ( coulf not eat anything past puree until 12 months ) and asthma which are linked to the blood clotting disorder… my daughter who is 6 months refuses baby food a lot. their pediatrian does not want to test for it. Is there anything special I should Take I am breastfeeding my daugher so I am going to take the optimal vitamin, but if I took everything you listed I work ne bankrupt lol. Please help I know I have both strands.

    • Dr Lynch September 30, 2014 at 4:28 am # Reply

      Hi Heather –

      Lifestyle, environment and food are HUGE players in this – so please apply the recommendations here on those – for everyone.

      I understand it is expensive if taking everything – which is why I highly recommend the basics above.
      These basics go a long way in helping people get better.

      Breastfeeding – I would take:
      – Vitamin D
      – Fish oil
      – Optimal Prenatal Protein Powder – or Optimal Prenatal
      – Probiotic

      I would use the ProBiota Infant for your daughter – the youngest.

      Please call my office at 800 547 9812, or Chat or email them – and let them know I am giving you a free Seeking Health Membership – that will help some. Saves you 10% off every order for a year.

      I’d order the 23andMe for all of you – and then run the report through MTHFR Support.

  191. Heather wheeler September 29, 2014 at 4:43 pm # Reply

    I forgot to tell you I had two miscarriages and I am taking a baby asprin and extra folic acid which I am going to switch to your vitamin line. I am worried about being a vegetarian now, I do eat fish eggs and seafood. I eat a lot of soy products. Please help me

    • Dr Lynch September 30, 2014 at 4:11 am # Reply

      Heather –

      Being a vegetarian can be fine – just need to make sure you are supporting with things like fish, eggs and seafood – or supplement.

      Soy is not that great – I’d really think about that and eliminate.

  192. Kim September 29, 2014 at 7:16 pm # Reply

    I don’t even know where to start and at my wits end. I am 37 and 5 years ago had gastric bypass. Although my weight is no longer an issue..everything else is. I tested positive for BRCA1, had a full hyst. I am very sensitive to supplements and medications. I got diagnosed with RA and it is vicious. Just got tested for MTHFR and have both mutations. My vit D is very low and dr said to try 50,000 1x week. Did that Sunday and was in the hospital for fainting, metallic taste, dizziness and completely out of it. So, now I am scared to try anything new. The only thing I take for my RA is LDN. I am considering having my bypass reversed as I feel it really messed up my immune system (gut) and whatever I try to do it fails. We eat whole, organic foods. I spend more on our grocery bill than our mortgage. :) Anyway, I want to start this protocol, but just worried on where to begin.

    • Dr Lynch September 30, 2014 at 3:53 am # Reply

      Kim – don’t start on this protocol – only thing I’d do are the lifestyle and dietary choices for now.

      I would consider reversing that bypass if possible. I agree it may be a big issue.

  193. Heather wheeler September 30, 2014 at 1:42 pm # Reply

    Dr Ben thank you so much … can I get the vitamin d fish supplement at the regular store?

    • Dr Lynch October 2, 2014 at 8:41 am # Reply

      Fish oil can be bought at many stores – if from a good company. There are a number of good ones out there. I forget the name currently – in a glass bottle – from Norway.

  194. Heather wheeler September 30, 2014 at 1:43 pm # Reply

    I was going to get the daily vitamin optimal line for my kids but should I wait

  195. Heather wheeler September 30, 2014 at 1:50 pm # Reply

    They habe probotic at babies r us is that ok

    • Dr Lynch October 2, 2014 at 8:40 am # Reply

      Probiotics at Toys R Us – definitely not ok.

  196. Juliette October 11, 2014 at 10:04 pm # Reply

    Hi, I’m 36yrs old and just found out I’m homozygous mthfr c667t.
    I have had a headache a weird headache for almost 3yrs.
    I did have high copper but it’s lower now. I still have the headache.
    It’s worse when my oestrogen rises I think.
    I had high levels of folic acid and b12 in a blood test. Don’t have any heavy metals.
    I am desperate to figure out why and get rid of them. I never have relief. Had an MRI 2 yrs ok. Showed nothing. Thankyou

    • Joe October 14, 2014 at 2:30 am # Reply

      I would suspect “Leaky Gut”. Did you take any perscription drugs before the headaches?

  197. Laura Richardson October 16, 2014 at 4:59 pm # Reply

    Okay…so I’m hetero for both C677T and A1298C. But, I have alot of other mutations, too.

    My problem is my NutraHacker Report states I should avoid Methyl B12 and Methyl donors due to homozygous mutations for my COMT gene (rs4633, rs4646312 & rs4680) and a heterozygous mutation for my COMT gene (rs5993882).

    In total, I have 8 homozygous and 9 heterozygous mutations that effect my neurotransmitter levels. (I have an overall total of 21 homozygous mutations and 37 heterozygous mutations)

    Help?!? Feeling hopelessly mutated! lol

  198. Aaron October 18, 2014 at 6:22 pm # Reply

    Hi – I’m homozygous for c677t – I read your protocol carefully – thank you so much for the info! I am deeply grateful to you!!! I’m taking the optimal multivitamin you suggest in Part I plus methyl b12 1000 mcg and I’m feeling a million times better – but not completely. Question: In part II, you suggest cycling through various b12 supplements some of which also include a) pyridoxal-5-phosphate and b) methylfolate – which are also included with the optimal multivitamin. Is it safe to experiment with Part II protocol while also on the optimal multivitamin – or would be too much pyridoxal-5-phosphate and methylfolate? thanks! Aaron

  199. Elizabeth October 23, 2014 at 8:28 pm # Reply

    I found out 3 months ago that I am homozygous for C677T. My functional medicine Dr. started me on Thorne Methyl-Gaurd Plus 3 caps/day, Orthomolecular Methyl B Complex 1 cap/day, and a multi vitamin called Pure Energy which is a private label for Body Logic md which contains 800 mcg of Folate. I hope to start trying to get pregnant for the first time in about 6 months. My Dr. said once I become pregnant to stop all supplements instead of the Methyl Gaurd Plus and then add a prenatal too. I am concerned about taking a baby Aspirin everyday while pregnant (which seems to be the recommendation from all the OB’s I have been calling) because it is a drug, and I do not know the long term side effects on a baby for taking Aspirin. Plus I have been dealing with systemic candida for 2 years after antibiotic use and I am afraid the Aspirin would make it worse. But I noticed you recommend Nattokinase, but I thought that ALL forms of Soy is bad. I already have high levels of bad estrogen which I am taking DIM for. What are your thoughts on this? And are there other things I should take as well for preconception? Thank you!

  200. Tammy October 25, 2014 at 8:35 pm # Reply

    Hi Dr. Ben,

    I just found out that I have the heterozygous genotype for the MTHFR C677T (C/T) and MTHFR A1298C (A/C) polymorphisms (compound Heterozygote). I also have hypothyroidism and have been on levothyroxine for about 10 years. My blood work also showed that I am deficient in Vitamin D and my ferritin is low. My serotonin and Gaba are also low along with my dopamine and glutamate but my epinephrine is high. Can you please suggest some supplements that I can take to head me in the right direction? I was thinking to start on the seeking health optimal multi with iron along with extra supplementation of vitamin d. Then slowly adding the active B12 Lozenge with L-MTHF. Please let me know your thoughts. Thank you for your time.

  201. Ale October 29, 2014 at 12:24 am # Reply

    Hello! I have the heterozygous C677T mutation of MTHFR. First of all, this is the first website i find with so much information, i could point my endocrinologist here as she has basically no clue of how much changes with this mutation.
    Anyway, my problem is that i am a transsexual woman and i developed a DVT 4 years ago, presumably because estrogen didn’t work good with this mutation. Is that the explanation, i know it increases risk for thrombosis because i should take estrogen, but isn’t there any possibility to still take estrogen with this mutation? I did not take since i had DVT, but it would help me alot to be able to take.
    Here nobody knows nothing and has no interest in knowing anything related to persons with GID, all i know is because i learn alone…and i self medicate as well
    Thank you!

  202. Penny November 1, 2014 at 4:47 am # Reply

    I am so confused? I recently tested MTHFR C677T, my Homocysteine Level is 23. I am still trying to understand it all. My doctor prescribed Cerefolin NAC. Please share any helpful information, thank you.

  203. Juli November 4, 2014 at 1:01 am # Reply

    My husband was recently diagnosed with MTHFR. We had our daughter tested and she has 2 copies of C677T MTHFR. Does that mean I also have MTHFR? I haven’t been tested yet.

  204. CARMEN MARIA CONSOSPO RODRIGUEZ November 11, 2014 at 10:48 pm # Reply

    Hi: I´m homozygous for the C677T MTHFR mutation. I bought the basic protocol, but I´m hypothyroid and I´ve low cortisol. I´m taking Natural Thyroid Hormone (NTH). then I ´ve serval question:
    1.- The NTH when must I Take it, before o after •Active B12 5000.
    2.- What can I take for the loe cortisol? and
    3.- Do you Know o meet a Doctor in MTHFR in Mexico? in your list there is one but she is denist.

    • Dr Lynch November 13, 2014 at 1:46 am # Reply

      Carmen –

      NTH you take before anything – but if taking a lozenge, you can take that right after and allow it to dissolve slowly.

      For the low cortisol, consider:
      Optimal Adrenal
      Adrenal Cortex

      I HIGHLY recommend Optimal Electrolyte also – esp if fatigued and low thyroid.

  205. kim November 12, 2014 at 12:22 pm # Reply

    Dear Dr. Ben

    Thank you for all that you do and all the research you have put into this!

    Quick Q- what do you do if your COMT and MTHFR are conflicting? MTHFR c677t +/+ and COMT ++
    COMT requires hydoxyb12 but MTHFR reqs methyl, what to do?
    Just gave birth 4 months ago, highly stressed, no sleep, poor immunity, panic/anxiety has set off, adrenals are weak, allergies are going wild. On a positive note, diet is good, responding well to a low histamine diet and seeing an NAET practitioner for allergies.

    • Dr Lynch November 13, 2014 at 1:33 am # Reply

      Kim –

      You focus on how you are feeling and lab results.

      People with MTHFR have a reduced ability to produce SAMe and those with COMT have a slowed ability to use it.

      COMT does not require hydroxoB12. That is incorrect information.

      COMT uses magnesium and SAMe.

      Pregnancy requires massive amounts of methylation and so does breastfeeding.

      Congratulations by the way on your baby :)

      I would focus on:
      – Adrenal Cortex – take 1 in the AM after breakfast
      – Optimal Adrenals – take 2 to 3 capsules in the AM before breakfast
      – Optimal Electrolytes – mix 1 scoop once to twice daily in a liter of water and drink throughout the day
      – Optimal Prenatal Protein Powder – mix 1/2 to 1 scoop into a smoothie for breakfast or lunch
      – Optimal Liposomal Vitamin C – one to two teaspoons daily
      – Optimal Vitamin D – 3 drops daily or 20 drops once weekly
      – Saccharomyces Boulardii – 1 capsule after dinner
      – ProBiota Bifido – 1 capsule after dinner
      – Magnesium Plus – 1 capsule before bed

      Those I believe will help support your adrenals, reduce your stress/anxiety, support your methylation and support your baby while breast feeding as well.

      All may be found at

      With those recommendations, I believe you will improve within a week – significantly.

      Let me know how you do with them!

  206. Rhonda November 23, 2014 at 3:33 pm # Reply

    Dr. Ben,
    I am heterozygous C677T and A1298C. I have had lifelong issues, but the older I get different issues are cropping up. Most recently, uncontrolled sweating. My dr did put me on a miniville patch which has slightly lessened the issue, but doing standard housework leaves me in a flare and I have to take frequent breaks. Could this be due to inefficient methylation or overmethylation. . I do take a SL methylfolate with methylcobalamin tablet once daily. This started 2 summers ago. I sweat so bad that I have skin breakdown. I read your blogs frequently, but don’t remember if this has ever been addressed. Thanks so much for your ongoing research. None of my drs are very familiar with this. We need physicians on board in SC. Rhonda

  207. lyndie s November 29, 2014 at 7:35 am # Reply

    Dear ben, I am homozygous C677T and have been “cheating death” numerous times what I feel have been way too close to death due to my type of genetic mutation to assist in higher risk of many possible issues. My doctor refuses to discuss and even to look up your research for not only his own practice of learning to help ones like me but also says he don’t have the time either to do that I even asked him to at minimh minimum discuss your work and website with other doctors to try and spread awareness. Besides him I have tried many many doctors and clinics. I have even gone to the Mayo clinic here in Minnesota. I seen two “specialists” and neither knew barely anything of my blood disorder and one of them even belittled my blood disorder (this happens to me 24/7 with every doctor or nurse that comes in contact with me and even every time I’ve been to the ER for emergic times caused by what I truly believe is my disorder. In 2012 I was in the hospital for a severe saddle pulmonary emboli stretching from one lung to another. First two days I was in ICU and then another 4 days in regular part of hospital. It was December 2012, I was 21. I am a female. Since that time my health has gotten very bad as time has gone on. The biggest issue I’ve been noticing is memory issues, short term is the worst and now my long term more so this year has taken a turn and I’ll be lucky if I remember things from the past that I use to. Other most borhersome issue is my in my arms, legs face and extremities at minimum. It started last year I believe, in my legs and I assumed it wad restless legs until I began to feel the sensations spread to my arms next then extremeties and face areas. The feeling is uncomfortable and feels jittery like shocking or pulses as if nerve spasms? I am unsure but so far my guess is neurological such as neuropathy but I am uncertain. Doctors pass me off and belittle my symptoms and I struggle with more symptoms as well bit these are the top two of most concerning to me. Also if I am sitting on the toilet for more than briefly or more than a few minutes, my legs go numb from either my hips down and when they do I lose feeling in them and have to try and move them to gain sensation back to stand on them. During which they feel sensation of charlie horses that don’t stop for a little while. i have followed your advice on a gluten free diet starting a little over a week ago. What made Me try it again was the past 1-2 months I’ve been having bad pains in my stomach that feel as if I haven’t ever ate in my life and as if my stomach and intestines are being ripped out. Since I stopped eating gluten in my diet my stomach has been feeling somewhat better. I would like to try to eliminate dairy also but I am worried of how I would since I am low in vitamin d already and moreso that I am having a fairly hard time with eliminating just gluten but it is worth it to me for my health and am willing to do whatever it takes to feel better and be healthier. .starting with me having eliminating gluten from my diet. I currently take 2,000 mcg of B12 “spring valley timed release” , 200 mg “spring valley” B6, 250 mg “spring valley” B1 thiamin, 800-1600 mcg “spring valley” folic acid (I don’t think it is the type of folate you recommend but I am having a hard time knowing what step to take right now to get on the right track because I am doing all of this on my own because no doctors I’ve seen will try truly to figure out what’s wrong with me and I for the past over two years since finding out my MTHFR homozygous C677T, have also been making all my own guesses at vitamin doses (which have had changes in doses over these past 2+years) and I also take Coumadin, two 4 mg tablets daily for life to prevent another clot and keep my blood thinner (the coumadin portion was advised by and dose decided by clinic/doctor. I have been on coumadin since december 2012 of coming into the ER for my saddle emboli. I keep holding onto hope for advances in science which I try to learn as much as I can because I want to learn molecular biology and want to help advance science one of being the topic of individual genomics as one area I feel among many topics is important and needed in advancement in science. I also want to be a molecular biologist to try and help cure diseases and or to advance whatever medical and scientific research there is if not add new knowledge bases of science where possible which I feel anything in the world is possible if one pushes hard enough for it which cannot explain enough when I say that you give me hope for the future and for science and I highly appreciate your life of hard dedication to every aspect that you have put into this and it means the world to me that you are fighting to spread its awareness and fight this cause with all you have+ some. I struggle with depression and anxiety and have alterations in moods that I truly feel are due to my bodys chemistry based off this disorder and that my body doesn’t handle stress as well as it could compared to a “normal” human who doesn’t consist of this mutation variation in their DNA makeup. I do notice that at times it seems anxiety and stress can heighten the painful uncomfortable sensation I feel in my arms legs etc. I do want to inform you that I was a frequent cannabis user and felt it was the only thing that assisted in the neuropathic type pains. For almost a month I have not smoked cannabis due to me finding I again have inflammation in my lungs that doctor pointed out in my visit over a week ago that seemed to have gotten worse afterthe bronchitis I had which lasted over a week and I seem to be higher prone to bronchitis this is my second time this year getting it and I had it last year also. (I have been around secondhand smoke from cigarettes all most of the now 23 years of my life. Currently I confide myself to my room since my grandma is an intensively high chain smoker. I am worried about my lungs because as of march of this year when a CT scan was done of them, there were “white specs and blotches” in them which the doctor at Mayo that went over it said he didn’t know what it was and guessed it was asthma. I have an inhaler that I use for emergic hard difficulty in breathing and chest pain but I tey to only use it in severe cause the recommended 2 puffs or so isn’t enough to help me and so I have to administer more albuterol puffs and being I know it’s a steroid so it’s likely what causes me to feel bad shakes after taking it and can’t relax in my body. I really hope I can see your response and realize this is a lot that I am posting. I tried last year posting or was earlier this year and I don’t see it but I’m hoping it was for a reason that this one you’ll see since I feel I am a little more wiser than before and also have more up to date symptoms and discussion. I look forward to hope of hearing back from you and also in hopes that you can guide me on what to also do about the doctors’ awareness in minnesota at minimum/how to push this so they hear me out and to spread awareness of this very vital disorder/DNA mutation that many suffer from including myself.
    All my love, faith, hope and support and blessings,
    -Lyndie Salo

    P.s. Dr. Ben, I hope I can follow in your footsteps someday and help the world with whatit needs more of (amazing scientific research&dedicated health providers.)

  208. Kristen December 3, 2014 at 8:09 pm # Reply

    My doctor recommends B12 injections instead of oral doses. What are your thoughts on this?

  209. Melinda "Jill" Johnson December 7, 2014 at 10:27 pm # Reply

    I am assuming because you said goat milk is okay, you are okay with A2 beta casein milk/dairy products? And prefer pasture eggs to minimize lectins?
    I really appreciate your website.
    Thank you,

  210. Ioana December 11, 2014 at 10:36 pm # Reply

    Dr Lynch,help!

    Thyroid hashimoto
    MTR-A2756 -AG
    MTRR 11 -AG
    MTRR A 66G -AG
    R297R -GT
    COM 61 -AG
    VDR Taq-AG
    BHMT 8 -CT
    I do not feel good.Isus:IRM head(everything
    ok just 3 milimeter demyelinations)
    I cannot get pregnant.About me:
    -2 miscarriages
    -3ectopic pregnancy
    -5IVF failed(Dr said my ovums are not good,poor quality )
    My estrogen test is elevated (3 period day)

    Pls,I need your help,I was trying to find any your email address but I was lucky.Maybe here you find me and send me an answer.Sry for my English.I can’t wait your answer.

  211. Paul December 12, 2014 at 12:28 am # Reply

    I’ve had two DVT’s and I’m prescribed warfarin for life. Can I take these products?

  212. Zori December 15, 2014 at 9:01 pm # Reply

    D-r Lynch,I am homozygous 677CT and heterozygous 66AG MTRR.
    I have been taking l-methylfolate for already 9 months. 3 weeks ago I added active b 12 of ‘Seeking health’. First, I started with 1/8, and then gradually reached 1/4 of b 12 tablet. Now I am taking 1/2 in the morning but I have a headache every day. Do you think I should go back to taking 1/4?

  213. Jennifer December 18, 2014 at 4:10 pm # Reply

    Thank you so much for this – it’s really helpful! I had two questions. Can you please explain why we should eliminate dairy? I thought by converting to organic, I would be okay. Also, what is the concern about cooking with gas?

    Thank you!

  214. Zori December 19, 2014 at 3:09 pm # Reply

    D-r Lynch I also forgot to add that during that period when I was taking b 12 and increasing the dose, I also took one tablet of ‘B minus” (of Seeking Health) everyday.

  215. Claire December 29, 2014 at 11:41 pm # Reply

    Hi Dr Lynch,
    Just wondering if you know about milk butyrophilin sensitivity? This showed up for me via cyrex labs test. I’m fine with casein etc.. I can’t find more info about it in general. Apparently it’s in the fatty partof the milk (which I thought was usually less allergenic). I really miss ghee and butter. I wonder if there is anything I can do to tolerate it again.
    Thanks for any tips

  216. don mau January 5, 2015 at 11:08 am # Reply

    New Research on how nanobacteria cause calcification in tissues that prevents antibiotics and other treatments from working. This nanobacteria commonly called Bartonella infection is very hard to detect and can only be detected using advanced methods. There is a newly developed method to overcome this nanobacteria calcification and once that is done treatments become much more effective.

  217. Rebecca January 5, 2015 at 9:05 pm # Reply

    Hi Dr Lynch
    I have had 3 recurrent miscarriages and feel I have had contradicting information regarding folic acid since reading your sight. Following the third miscarriage blood work was done and results came back as MTHFR C677T Homozygous and PAI-1 4G/5G Heterozygous.

    I was prescribed 5mg folic acid and on conception 75mg baby asprin and low molecular weight heparin. The strange thing is that my first pregnancy went to the longest term of 12 weeks when I wasn’t on the high dose folic acid. Also whenever I take pre-conception multi vitamins they mess up my menstrual cycle.

    I would really appreciate your thoughts on this as I cannot see a response to other people’s pregnancy related messages. Desperate to have a successful pregnancy. Please please help.

  218. Sam January 7, 2015 at 2:27 am # Reply

    Dr Ben-

    I recently tested homozygous for the C677T MTHFR Mutation and — for A129C mutation. I haven’t had a more comprehensive testing such as Yasko or 23andme. (Not sure if this is something I should do?. In 2013 I had my B12 tested and it was high at 1129 (reference 211-911), although I had been taking Jarrow methylcolbalamin 5000 mcg about 1-2 a week on my own, which I chewed. Homocysteine was in normal range 10.1 (reference 4.5-12.4). This year I had my Methylmalonic Acid tested and it was .16 (reference <0.40). I've been told a few times that I don't need to supplement with methylcobalamin. My naturopath wants me to start 5 mg L5-MTHFR, twice a week. I am nervous to start this high a dose after reading what you have to say.

    My medical history includes recent diagnosis (through salvia testing) of adrenal fatigue (very low morning and noon and skirting the edge of low in the evening times). I have Lyme disease, Babesia Duncani, Mycoplasma, Chlamydia pneumoniae. I have also had a urine challenge test 4 years ago which showed me high in mercury and lead. In 2008 I had total thyroidectomy for hugh goiter associated with Graves disease. Shortly thereafter, when my thyroid replacement dose was too low, my Lyme symptoms largely emerged, although I think it may have been in my body for a few years prior. I have done a number of rounds of oral antibiotics without much success, although treatment was interrupted a few times. I did IM injections of Bicillin with initial improvement, some backsliding in symptoms with addition of Biaxin and Tindamax. Eventually, I started to transition onto a different oral regime of antibiotics and just tanked. I don't know why. I felt very toxic after the whole process and ended up taking a break from antibiotics and haven't gone back on feeling gun shy. IV antibiotics have been suggested to me and I think it might be a good idea as I have more neurological and fatigue symptoms, which sometimes can respond better to IV than oral. However, if I have issues with methylation/detox (I also can't handle liposomal glutathione) I want to make sure I am addressing these deficiencies before or at least during antibiotic treatment.

    My questions are:
    1) With the homogenyous 677T mutation, a high B12 result (may be in normal range without supplementation), a normal Methylmalonic Acid and normal homocysteine, should one still be taking methylcolbalamin? Even with a normal methylmalonic acid test could one still be deficient or not absorbing B12?

    2) Do you know if not being able to tolerate glutathione may indicate an issue with sulpher or allergy to?

    3) How important do you think more comprehensive testing is for someone with these health issues?

  219. Heather Snowden January 20, 2015 at 5:22 am # Reply

    Dr. Ben,
    I was diagnosed positive for 2 copies of C677T Homozygous Mutation. The first year it was controlled with Deplin, first 7.5mg and then increasing to 15mg per day. My body built a resistance to the Deplin and I started having the same symptoms of severe abdominal pain and weight loss. My doctor switch to Metnax once a day. After 6 months was increased to two tablets daily one in am one in afternoon. About 6 months ago I started to loss weight again, slowly at first and then much quicker in the last 3 months. Also in the last year I have been diagnosed with ADD which I had never had before. I was an extremely type A personality that had everything in my life organized. Then I couldn’t even focus on one subject for more than a few minutes and would notice something else and move on before completing the first task.
    A little about my background I have suffered from severe depression and insomnia since early childhood and developed unexplained anxiety in my late 20’s. At the age of 28 I was diagnosed with severe Fibromyalgia and due to CFS and incredible pain and weakness had to stop working. I am now disabled. At the onset of my diagnosis of Fibro I had what was called Leaky Gut Syndrome. This is and constant pain led to my diagnosis. I now know that it was a flare up of my gene deficiency. Somehow my body regulated itself on its own that time, but now I have Leaky Gut again and have lost so much weight that I am skin and bones. This is causing nerves to be pinched in-between bones and my pain has increased. In April I also started having severe Migraines so bad that I ended up in the hospital 3 times before a neurologist took me seriously. I am now receiving botox injections but they are only effective for short periods of time. I found a group of doctors who specialize in the deficiency, but have call and asked for test results and other forms of therapies with no response in between visits. Their therapies consist of drinking collustrum daily, taking a tbsp. of Coconut oil, vitamin B12 shots and increased amounts of vitamin D. I have been doing all of the above, plus forcing myself to eat (no appetite) non processed high quality foods that they recommended. All I can say is I feel worse than I did when I went to see them. I’m at a lose and don’t want to go back because I don’t feel that their communication is what it should be and because these therapies aren’t working.

    I am hoping that maybe you can give me some advice and direction. If I lose any more weight I will be hospitalized. And my insurance refuses to pay for this new group of doctors. I can’t afford to keep trying new things with them because I live on a fixed income. Please help me! I have no where else to go!!!

    • evy January 20, 2015 at 9:16 pm # Reply

      ugg, Heather, when I read stories like yours, I come to think that my daughter’s health issues (which are significant) are small in comparison. I suppose you’ve also had thyroid, hormone and adrenal testing done?

      Praying you will find some answers!


  220. Michelle Poe January 21, 2015 at 5:17 pm # Reply

    Hello and thank you SO much for this incredible site. I am 37 and just learned i have the C677T mutation. Heterozygous. I see your water purifier you recommend. I want to do all i can to make all the best adjustments! We have a Kangan machine and have had one for 3 years. Is the machine you suggest similar to the Kangan? Or would you suggest getting a different one? Appreciate your help!

  221. David Cairns January 28, 2015 at 7:11 am # Reply

    Hi Ben,

    I have just got my 23andMe Genetic Genie results.
    Do you have any recommendations in which order to address the various SNPs?

    COMT V158M rs4680 AA +/+
    COMT H62H rs4633 TT +/+
    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 TT +/+
    VDR Taq rs731236 GG -/-
    MAO A R297R rs6323 T +/+
    ACAT1-02 rs3741049 AG +/-
    MTHFR C677T rs1801133 AA +/+
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 TT -/-
    MTR A2756G rs1805087 AA -/-
    MTRR A66G rs1801394 AG +/-
    MTRR H595Y not found n/a n/a
    MTRR K350A rs162036 AG +/-
    MTRR R415T not found n/a n/a
    MTRR A664A rs1802059 AG +/-
    BHMT-02 rs567754 CT +/-
    BHMT-04 not found n/a n/a
    BHMT-08 rs651852 CT +/-
    AHCY-01 rs819147 TT -/-
    AHCY-02 not found n/a n/a
    AHCY-19 rs819171 TT -/-
    CBS C699T rs234706 GG -/-
    CBS A360A rs1801181 AG +/-
    CBS N212N not found n/a n/a
    SHMT1 C1420T not found n/a n/a

    I have tried to follow the protocol but the headaches become to much quite early on.
    Now looking into Hydroxycobalamin B12 injections

    All the best,

  222. andrea k January 29, 2015 at 2:26 am # Reply

    i was just diagnosed with homozygous mthfr c667t mutation. i have no idea where to begin. i found out because my ob tested me after 2 recent miscarriages ( i have had 1 heatlhy term pregnancy). i had homo cysteine levels drawn today and factor v. i am wanting to have more children. where do i begin with supplements? what other testing should i seek out?

  223. Emily February 11, 2015 at 1:14 am # Reply

    Hello. Thank you for your extremely informational and helpful website!!! I have just been diagnosed as homozygous for a MTHFR mutation, after 3 miscarriages. I have always been very healthy (before the miscarriages), and strive to maintain a raw produce + protein (chicken, eggs, & fish) diet. Would starting with taking your Kids Optimal Multi (perhaps 8 capsules a day, instead of the recommended 6, as I plan on becoming pregnant soon) and then slowly adding 400 mcg of methyfolate as I’m able to handle it be good during pregnancy? I understand I’ll need to watch my symptoms and take electrolytes and glutathyione accordingly, as well. Thank you!

    • Dr Lynch February 11, 2015 at 1:34 pm # Reply

      Emily –

      If you tolerate it well and feel great, then it should be fine to do as you suggest above.

      Do ask your physician of course.

      There are well trained docs at – in the physician directory.

  224. Justine February 15, 2015 at 12:41 pm # Reply

    Hello dr. Ben, I am homozygous c677t and homozygous comt. Ive had a whole lot of issues ranging from depression to colitus tedulting in a proctocolectomy. I now have a j- pouch wich is forming sinuses and fistulas. I am concerned about these issues since I am only 28 & I have a 11 month old & a three year old (with autism and digestive issues) Is it safe to take all of these nutrients/supplements while breastfeeding? I know some of them are but im not sure mainly about the tumeric/liver support/neutralize/and flow. Also thanks so much for everything… you helped my nd with a treatment plan for my 3 year old and while he is not 100% he is so so much better so thanks for everything you do.

  225. Wendy February 15, 2015 at 3:31 pm # Reply

    Hello Dr. Lynch,
    I am homozygous C677T – I don’t know about the A version, as my doctor will not test for it. I ordered your supplements including Turmeric, Vitamin D Oil, Optimal Multi, and B12 with L5MTHF. I was taking the B12 and felt fine (Now I know I skipped the Active B12, so I am correcting that.) When I added the vitamin, I noticed a headache would set in within an hour or so. When I figured out that I was taking the wrong B12 (after 4-5 days of taking it), I stopped and continued taking the vitamin, but I only took 2 and still got the headache. Can you tell me what you think I should do? I eat a very clean AIP diet (6 months) and I take probiotics, Iron, glutathione, and chaste tree. I’m confused about why the B12 L5MTHF made feel so great until I added the vitamin. Thank you for what you do. You give me hope that I may eventually get this right and feel like a normal person again.

  226. Fred C February 18, 2015 at 5:48 pm # Reply

    Dr Lynch: I posted updated info on TESTING but also wanted to inform you. 23andMe and MTHFRSupport have 34 pages!!!! of +/+ +/- & -/- with 11 out of I think you said 20 MTHFR markers and 8 pages of (over my head) how everything works. For $138 total, people that say can’t afford need to beg, borry or save to get this LIFE changing info. I wish I had the money to form a GRANT for testing. Anyway I am C677T +/- and A1298C-/-. Even though I have 1 marker, I discovered a life changing clue!!!! I suffer, all my life, from MAJOR anxiety!!! I can’t take anti-depression meds and have med intolerance, like some BRANDS work or I don’t need nowhere the dose or it stays in my system to long!!!! I have been on some kind of BENZO for 30 years with off for 3 months. TESTING SHOWED I CAN’T PRODUCE GABA!!!!! Out of 10 markers for “Glutemate & GABA” 5 are +/+ 2 are +/-!!!! Unreal!!!! No GABA was causing HR and BP problem.
    QUESTIONS: I am seeing a ND with your training. She is doing to big apporach, like you said, to MTHFR. I had stopped ALL vit. waiting for testing results. She started me on 2 veg. B vit. with 800mg of folate. Also I took SAMe for a week and BOTH fired up my “tinnitus” in left ear. What could cause this? Since SAMe is “CEO of the body” am I going to have to suffer with this MAJOR problem?
    You do your research because you have both MTHFR mutations, how would I go about researching my GABA problem? You state A1298C, mind is find but A1297C is +/+!!! Do they effect each other or totaly seperate? Thanks for your time. FMC NOTE: I have started leafy greens and have noticed neuropathy, that I talked about, is getting better!!

    • Mark February 18, 2015 at 8:09 pm # Reply

      @ Fred C – I am MTHFR C677T +/+. I also did 23andme and ran it thru Sterling’s MTHFRSupport but cannot access my report details online as the site is updating. I Can you please list the exact the names of the genes for both GABA and GLUTAMATE markers so I can see what mutations I may have also? Would very much appreciate!

      • Fred C March 7, 2015 at 7:10 pm # Reply

        Hey Mark: did you get your results back from MTHFRSupport????

  227. Sarah March 3, 2015 at 9:52 pm # Reply

    Hi Dr Ben, I have recently been diagnosed as homozygous C677 and was initially happy to have finally found the cause of some of my health issues (lifelong frequent infections, migraines, IBS, gluten intolerance, cystic acne, homocysteine currently 15) but quickly became very overwhelmed at how to take care of myself and my family (my daughter and husband are both compound heterozygous). Our doc started us on 2000 mcg of methylfolate (my 9 yr old on 1000mcg), but said our B12 levels looked fine so didn’t advise anything other than methylfolate. At first I felt like the fog was lifted and I could think again for the first time in years. After reading your site I realized that we should probably still add in some B12, but every time I take even 100 mcg I get a headache and heart palpitations. I had an episode last year where I passed out and was rushed to the ER and they said I seemed fine other than low potassium. I have had 2 more episodes like then since, but didn’t go to the ER. I don’t know if these episodes are related, but I thought I should mention them as well. I could really use a little advise regarding what we should do next. I read to try the hydroxocobalamin, but should I do this instead of or in addition to the methylB12? Also, is B12 necessary for all MTHFR people? Any suggestions on what we should try next? I would really appreciate any advice as I am having a hard time sifting through all of this myself and I am feeling pressure to come to some sort of protocol to help my daughter not follow in my footsteps (health wise).

  228. Annie March 4, 2015 at 6:22 pm # Reply

    Dr. Ben,

    Thank you, thank you, thank you for your research and your supplements.

    I was tested for the MTHFR mutation in between having my 2 girls. I am compound heterozygous for 677 and 1298. Back then, there was not as much information available online, including your website. My doctors promptly put me on baby aspirin and Folbic throughout the pregnancy with my 2nd child. They were more worried about clotting than any folate or B12 deficiency. While I was ecstatic to carry her to term after repeated miscarriages, I felt horrible physically from taking the Folbic. I felt nauseated, tired, run down, and even developed anemia by the end of the pregnancy. My doctors told me that I didn’t have to worry about the MTHFR unless I was trying to conceive again. So I believed them.

    In the years that followed, I was constantly tired, but I thought it was just having 2 young children. But I noticed I did not feel better after they got older and I was getting plenty of sleep. I started researching about MTHFR as I had read what types of illnesses it was linked to. I came across your website and read through many of your relevant posts. I also watched an online presentation by Dr. Neil Rawlins. Finally, I realized my folic acid supplements were not helping, but actually making me feel worse.

    I recently ordered your Active B12 with L Methylfolate lozenges, and it is changing my life. Thank you so, so much!!


  229. Ray March 6, 2015 at 2:22 pm # Reply

    Where can I find objective, science-based information about MTHFR from a source that is not trying to sell a product or service that “may” affect their belief or opinion?

    “After all, is not about me – it is about how I can help you.” How does your selling me the product not be about you? There are many places that I can purchase supplements.