MTHFR Testing? Get your MTHFR Test Here

MTHFR Testing and MTHFR Test Kit from Spectracell LabsMTHFR Testing is important – and inexpensive.

The benefits of MTHFR testing are tremendous as it allows you to be proactive in your health instead of sitting idly by wondering why you have a myriad of complicated symptoms which doctors seem to only make worse.

If you already know you have a MTHFR mutation, especially more than one copy (homozygous or compound heterozygous), then I believe you should be notifying all your siblings and relatives – and parents – and children.

They need to test for MTHFR  – again – especially if homozygous or compound heterozygous. A single copy is very common and not very severe in many cases – in some cases, a single MTHFR mutation can contribute to many health problems.

If you suspect you have a MTHFR mutation but are not sure, then read this article which provides a list of conditions which can be caused by or worsened by MTHFR mutations.

If you are a physician and are wondering if you should screen your patient for MTHFR, then read this article which provides key points which help identify potential candidates with MTHFR mutations.

Need to order a MTHFR test?
Order your MTHFR Test Kit here.

FAQ on MTHFR Testing:

  1. Can I order a MTHFR Test Kit from you? Yes. Simply order it from here.
  2. When will I get results back? Within 14 to 20 days.
  3. How do I get notified of my results? Via email from Dr Lynch
  4. Are my results protected from insurance companies? Yes, if you don’t sign your name saying you allow insurance companies to be notified.
  5. How much does a MTHFR Test cost? It costs $195 when ordered through Dr Lynch
  6. Does insurance cover the MTHFR Test? Typically, yes, if your doctor orders it; not if you order it through Dr Lynch.
  7. Which lab do you go through for your MTHFR testing? Spectracell Labs. Quest also does it.
  8. Where do I go to get my blood drawn? You can go to your doctor or any blood draw center such as Lab Corp.
  9. Where do I mail my blood sample? You use the enclosed postage-paid envelope and send it directly to Spectracell.
  10. What do I do if I find out I have a MTHFR mutation? You can bring it to you doctor and see what they can do for you. Many doctors do not understand the MTHFR mutation and the effects it can cause; however, more and more are slowly waking up to the seriousness of MTHFR mutations.
  11. What supplements or prescriptions do you recommend if I have a MTHFR mutation? Requires a long, drawn out answer. Not going there at the moment.
  12. Is the blood test accurate? Yes. Very.
  13. Where can I find a doctor that knows about MTHFR? Try these medical associations.

Do you have any questions about MTHFR testing or how to obtain your MTHFR Test Kit? Please comment below.


95 Responses to “MTHFR Testing? Get your MTHFR Test Here”

  1. Lindsey January 26, 2012 at 5:56 pm # Reply

    I was diagnosed compound heterozygous through a thrombophilia panel. However, I am confused as to why you suggest getting tested again if compound heterozygous as stated above?

    • Dr Ben January 27, 2012 at 1:16 am # Reply

      Lindsey –

      No need to get tested again for MTHFR if you already know which mutations you have.

      This is for people who do not yet have MTHFR testing.

      • Ashley February 5, 2013 at 1:30 am # Reply

        Does the Thrombofilia panel tell if you have mthfr mutation? I have had 6 miscarriages

  2. Olivia February 27, 2012 at 7:17 pm # Reply

    Im in the UK and would like to get tested. Is it possible to send a kit to the UK or do you know of any uk or European lab doing the testing?
    Thank you

    • Dr Ben February 28, 2012 at 7:04 am # Reply

      Anyone here help Olivia with a lab in the UK for MTHFR?

  3. Lynn_M March 31, 2012 at 3:08 am # Reply

    Getting test results takes a lot longer than they say. I ordered my kit on 3/1. After a week, I hadn’t received the kit so I called. I finally received the kit on 3/13. I FedExed it to SpectraCell on 3/15. Today is 3/30, 14 days after I sent in my blood sample. I still don’t have my results. I called Health-E Goods about it, they just said they had to wait on SpectraCell. They didn’t offer to call SpectraCell to see what was happening.

    I have since learned that there are other places to get this test done, even without a doctor’s Rx. And no blood draw required. I can’t recommend getting the test through this website.

  4. Sarah April 24, 2012 at 3:40 pm # Reply

    I do think in fairness that you should change #2 results in 7-14 days

    I have been waiting 2 weeks and called in to see how much longer seeing as I have an appt. this week and wanted Dr. to go over results. Was told by your staff that results take about a month. I will call my Dr. to reschedule until after they come in.
    I know it’s the lab, not you but dissapointed.

    • Lynn_M April 24, 2012 at 7:04 pm # Reply

      I found out that it’s not necessarily the lab that is needing the extra time. I FedExed my sample on a Thursday. On the Thursday two weeks later, after I didn’t have my results, I call Dr. Ben’s office. I was told sometimes the lab takes longer, and they were waiting on the lab. The next Monday, I contacted Spectracell directly. They told me they had “safe sent” my results to Dr. Ben 8 days after they had received my sample. After I learned that Dr. Ben had been sitting on my test results for over a week, I called the office, who said sometimes Dr. Ben needs extra time to write his report. I then sent an email to Dr. Ben, saying I knew he had my results, and he finally emailed my results to me that afternoon. I received a copy of Spectracell’s report, with no further input from Dr. Ben.

      I sent a followup email to Dr. Ben, saying I was unhappy about what I was told by his staff at the office, and that they should change the time on the website that it takes to get results. He said they would, and apologized for being so overloaded that he didn’t get the results out sooner. He certainly seems to have a heart for helping those with MTHFR mutations, but I think some kinks need to get worked out on getting MTHFR results to folks on a more timely basis.

      • Dr Ben April 24, 2012 at 7:49 pm # Reply

        Lynn –

        Thank you for your comment.

        I have updated the websites. The time required to obtain results for the MTHFR Test is 14 to 20 days. Spectracell can vary immensely in getting their results to me – anywhere from 7 days to 20 days.

        I have a system now that is working well. I just received three new test results on Friday and sent them out today.

        I thank you for your patience Lynn on this. Sorry to have sat on your results. I understand how important it is to get them timely and the frustration when not getting them on time.
        Spectracell was timely with your results – I wasn’t.

        • Lynn_M April 30, 2012 at 4:20 pm # Reply

          Dr. Ben,
          I’m glad you’ve made the changes in your system and the time you show as needed for results. I was hesitant about sharing my story, because I wasn’t interested in making you look bad, but it appeared from Sarah’s story that there were still problems. I appreciate your acknowledgement of the problem, and also that you did respond. Thanks for your work on this website and your research into MTHFR.

          • Dr Ben April 30, 2012 at 4:40 pm #

            You bet, Lynn. There’s always room for improvement and that is something I work on continually. Feedback is very important and I take it seriously.

    • Dr Ben April 24, 2012 at 7:54 pm # Reply

      Sarah –

      I have changed the timeframe to state 14 to 20 days. Spectracell is inconsistent in timing. I have checked to see if your results are in and they are not as of yet.

  5. Lucina Botond April 28, 2012 at 3:43 pm # Reply

    Dr. Ben,

    How do I learn about the other mutations that you have mentioned in connection with MTHFR? One of these is “CBS.” I don’t know where to read up on these problems. One of your posts on another page says that earlier this year you had planned to make a test for those other mutations available on your site. Any update on when this might happen?


    • Dr Ben April 28, 2012 at 8:14 pm # Reply

      Lucina –

      I talk a bit about the other mutations here in this presentation on methylation and MTHFR

      The methylation genetic test that I am making is taking the lab quite some time to validate the test results. I’m still hoping it will get done here within the next couple months.

  6. julie July 26, 2012 at 5:09 pm # Reply

    i just received my mthfr blood test kit from spectracell in the mail. i ordered it through you and paid you, but the forms enclosed with the kit ask for credit card information. do i need to fill this out again on the forms? will i be charged twice?

    • Kim-S October 3, 2012 at 12:24 am # Reply

      I also just received my blood test Kit from Spectracell and it is somewhat confusing. There is nothing stating that I have paid, but just the form asking for credit card information. Also there are two tubes in the box. Do I have both tubes filled or just one? I think just one, but maybe I should do both to be on the safe side?The slip of instructions they sent doesn’t say anything about the MTHFR test, do I follow the instructions for the Omega-3-index which comes right above it and calls for the purple top tube which is the color they sent? Should I check the MTHFR Genotyping box and write in $150 on the amount paid? You need to have more information on this page so people know what to expect and what to do.

      • julie October 3, 2012 at 4:40 am # Reply

        I eventually had to get a refund from this site. There was nowhere to get the test done. No lab would approve it without a real doctor’s name on the slip, no one would do the blood draw. I spent hours trying to find a place and it all ended up being for nothing.

    • Lisa October 8, 2012 at 4:36 pm # Reply

      I called the lab. You fill out the patient information (section 1).
      When it comes to payment you put (section 4): Physician Practitioner and then: Credit Card on file, then you go to section 7 and mark MTHFR Genotyping.

      Then you take it to the lab. This is all you do.
      I called the local lab that does drug testing for local businesses. They are happy to do the blood draw and Fed Ex picks up from their every day at 3PM so I can ship it from there as well, for $25.00

      • julie October 8, 2012 at 8:27 pm # Reply

        Did the lab slip you got from this website actually have a physician’s name on it? Because the one I received only said Living Well LLC (no doctor’s name), and as a result, no lab would draw my blood. They all refused and said that the slip needed an actual doctor’s name on it. I’d just check to make sure about this before you take the trouble to drive to the lab. I ended up just requesting the MTHFR test from my regular doctor and he wrote up a slip for it and I just went to Quest or LabCorp or one of those.

        • Kim Siebert October 8, 2012 at 8:47 pm # Reply

          Luckily I live in a state where any adult is allowed to order their own lab tests, so that isn’t an issue here. I put Dr. Ben Lynch down as the physician, I assume that is what I was supposed to do. I called a place where a person can get various labs done and they said they would do the draw for a fee and take care of the shipping. (It comes with a prepaid shipping label and the packaging materials.)

          • julie October 10, 2012 at 2:12 am #

            wow- sounds like paradise! that’s definitely not the case in california. glad it’s working for you!

  7. Tina August 15, 2012 at 4:52 pm # Reply

    Dr. Ben, I would like to know if there is a Dr. In the metro-detroit area of Michigan. I have c677Tmutation and A1298c mutation. I also have Hashimoto thyroid disease,gluten sensitivity.yeast infection,heavy metal toxcity and hypoglycemic. I’m going to be 60 years old in a few mths. Will I ever feel better.? I;m not sure if I’m on the right amount of medicine, my Dr. also has me on estradiol and progesterone. I know there isn’t many Drs. who spealize in MTHFR but I would like to try and get some answers.What she has me on os Folate Forte B6 50mg. folic acid 5mg. vit.b12 1mg and betaine 500mg. is that enough?

    • Dr Ben August 17, 2012 at 7:13 am # Reply

      Hi Tina –

      I do not agree with the 5 mg of folic acid at all – not even a tiny bit.

      At your age, 5 mg of folic acid daily can be a detriment. I highly recommend you talk with your doctor about getting off of that amount of folic acid and switch to methylfolate.

      Please read this article on C677T MTHFR Protocol. It also applies to the compound heterozygous MTHFR mutation -which you have.

      I do not know of any doctors in Detroit. I do recommend you visit this webpage to find a doctor and review the medical associations that I recommend there. You may find a good doc who knows about MTHFR there.

  8. Darlene October 1, 2012 at 1:12 pm # Reply

    Does anyone know of any doctors in North Carolina that treat MTHFR?

    • Connie January 8, 2013 at 11:24 pm # Reply

      I am being treated for MTHFR by Dr. Weston Saunders in Winston-Salem, NC. He is an integrative physician who is a recent graduate of Wake Forest School of Medicine (a real MD). You might want to see about getting an appointment with him. He accepts some insurance. I have Blue Cross/Blue Shield, but there are others he will file.

      Good Luck!

  9. Nat Folino October 2, 2012 at 1:41 am # Reply

    My ND (in Canada) is testing me for the MTHFR mutation however my understanding is that it only includes the C677T variant. I have NH Follicular Lymphoma and was directed to you through a family friend. Suggestions on how to proceed would be appreciated.

    • Mackensey February 28, 2014 at 6:45 pm # Reply

      Hi Nat

      Did you try ? They offer both the 677 and 1298 test in Canada. You can have your ND contact them.

  10. Diane October 10, 2012 at 2:19 pm # Reply

    I had the MTHFR test done. I first received notice that I had no markers for MTHFR. A week or two later, I received ‘updated’ results that I am heterzygous 1298 and 677. I’m not sure what to believe. I called Spectracell and they responded that my first results were wrong due to a wrong entry in the computer. How can I be sure of my results???

  11. Cara October 25, 2012 at 4:04 am # Reply

    Is it possible to get an MTHFR mutation test with a finger stick only?

  12. Nick November 22, 2012 at 4:50 pm # Reply

    I suspect I may have the mutation or some variant as I have have multiple symptoms which have not been alleviated through conventional medicine.

    I started taking FolaPro L-5-MTHF 800mcg 4X daily a few months back. Initially – for the first few weeks I felt a boost on it and a definite improvement on my mood.

    This have not lasted, so i am wondering if I now need to supplement with a methylated B12 and or Niacin?

    Second question: Now that I am supplementing using the L-5-MTHF, would this skew the results of an actual blood test for the mutation?



    • Dr Ben November 23, 2012 at 8:14 pm # Reply

      Hi Nick –

      You may have used up your B12 and now just methyl trapping.

      Yes – I would add in B12 to your protocol. Consider the Active B12 Lozenge with L-5-MTHF. It is easy to use and inexpensive – yet very effective.
      Start low and work up.

      One uses Niacin typically when the symptoms of anger, irritability and high anxiety occur.

      Testing for the MTHFR mutation is not affected by supplementation. Your genes are set. Your epigenetics are not. This test is simply testing a specific area of your MTHFR gene and cannot be affected from anything you do or take.

      • Nick November 25, 2012 at 2:16 am # Reply

        Thanks! I purchased some sub-lingual methylated B12 – 1000 mcg. I took 1/2 a tab today and out of the blue, I felt agitation/anxiety. I am wondering if I should add the niacin or perhaps the B12 is too high to start?



        • Dr Ben November 25, 2012 at 3:44 am # Reply

          Hi Nick – yes – you likely need some niacin. Consider 50 mg every 30 minutes until agitation is gone.

  13. Mary January 24, 2013 at 2:17 am # Reply

    I was tested and and homozygous. I am working on getting my own copy of the lab result so i can show my family physician. And for sake of my 3 siblings, how should their doctors write the lab order? Is it simply “MTHFR” ?

  14. Sham April 2, 2013 at 3:01 am # Reply

    Hi dr lynch
    Do you recommend the test 23andme as it covers many more than just mthfr at a low cost?

    • Debbie April 4, 2013 at 8:08 am # Reply

      Did you get a response to this question? I also want the SNPs which they do. I read somewhere Dr. Ben says it must be a blood test to be accurate but he doesn’t do any SNPs testing so I am also looking for this at a reasonable cost.

      • Dr Ben April 5, 2013 at 9:24 pm # Reply

        Hi Debbie –

        There is a new saliva cheek swab MTHFR test that is available from which will run about $195 or so. This is great for kids and those who hate needles ;)

        It does not have to be a blood test to be accurate anymore – times have changed.

        Blood DNA testing can be inaccurate also – I’ve seen it. I actually tried creating a DNA test based on some SNPs that I wanted to screen for in people but I stopped developing it because my results were too inconsistent. DNA Testing can have errors – blood or saliva.

        I’ve been pretty impressed with 23andMe DNA Test lately and I have been recommending this test a lot. I even bought 5 kits – one for my whole family including me. Results in about 4 weeks.

        The 23andMe DNA Test does not do SUOX but that is ok as a history and lab can quickly identify if SUOX is an issue.

  15. Heidi April 5, 2013 at 9:57 pm # Reply

    I am wondering if taking the methyl-folate or methyl-b12 will interfere with the MTHFR test results or if I am fine to start these things before I am tested.

    • Heidi April 5, 2013 at 10:00 pm # Reply

      Apologies, I just read above that this question was answered.

      “Testing for the MTHFR mutation is not affected by supplementation. Your genes are set. Your epigenetics are not. This test is simply testing a specific area of your MTHFR gene and cannot be affected from anything you do or take.”

      • Heidi May 10, 2013 at 11:24 pm # Reply

        I do think my homocystine levels were affected though since I did start taking methyl folate and methyl b12 after I found out I had one copy of the 677 variant but before they tested my homocysteine levels

  16. Randy Domingue April 18, 2013 at 6:46 pm # Reply

    Dr. Ben

    My son and I were tested and found to each have 2 copies of the A1298C mutation. Currently my doctor is getting familiar with the issue so eventually I will have some answers from her. In your opinion, what is the best approach when first addressing this issue? Is methyl-B12 & Folate combo a good start?

    Thanks for your feedback,


    • Randy Domingue May 10, 2013 at 9:16 pm # Reply

      Thanks for skipping over my question to jump to Becky. Much appreciated!

      • Carolyn Nigari June 6, 2013 at 12:58 pm # Reply

        Randy, Although Dr Ben is helping here with this message board, he is also using this as a marketing tool for new clients. You probably shouldn’t have mentioned you were seeing another doctor already.

        • Dr Ben June 6, 2013 at 8:18 pm # Reply

          Carolyn – thank you for your thoughtfulness.

          I am not using this message board as a marketing tool for new clients ;)

          It is for others to help each other.

          I am not accepting new clients – and – in fact – I am not accepting any clients at all. I am no longer doing consults.

          Please do share which doctors you are seeing and how they are helping you if so – more the better!

  17. Becky May 10, 2013 at 7:17 pm # Reply

    I have a doctor who will request the MTHFR tesing, however, she needs to know a code so that the insurance will cover it. Does anyone know the code for this test?

    • Dr Ben May 10, 2013 at 7:50 pm # Reply

      Becky –

      Need to have your doctor look up codes for what is relevant to you:
      – Elevated Homocysteine
      – Recurrent Miscarriage
      – Methotrexate Sensitivity
      – Folate Deficiency
      – Infertility

      These are typically triggers which do tend to pay for the MTHFR testing. Do keep in mind that they vary from company to company.

      • Becky May 18, 2013 at 12:52 am # Reply

        Hi Dr. Ben,

        I just ordered 4 test kits for the family from 23and me. I hope the saliva test is as
        good as the blood test. I got the email about running the data through this web site.
        I am excited to hear more. Happy to donate when I know where and how.

        It is a wonderful thing you do for us.


  18. Samantha May 13, 2013 at 2:03 am # Reply

    Dr. Ben, thank you for the wealth of information on your site.

    I tested through Genomind and the results indicate that I have MTHFR, but don’t specify the allele and how many copies. Should I test through 23andme to get more info? Does that influence treatment? Would testing through Labcorp provide more information about the mutations I have?


    • Dr Ben May 13, 2013 at 6:07 pm # Reply

      Samantha – I’d contact Genomind and ask for your MTHFR specifics.

      Yes, 23andme would definitely provide much more genetic information about you which may be applied towards influencing your doctor’s treatment plan.

  19. stitches May 16, 2013 at 3:48 pm # Reply

    I had requested the MTHFR test from my doctor. The results came back showing the 677 was ok so the testing stopped there since both 677 genes were ok. Is that how the labs tests or did my doctor not order the 1298?

  20. Angela May 21, 2013 at 4:01 am # Reply

    Was wondering if somewhere in your available testing if you test for the Reduced Folate Carrier Gene?

  21. Shannon May 24, 2013 at 11:38 pm # Reply

    Which test kit do you recommend for finding out if you have the CBS mutation?

    • Angela May 25, 2013 at 11:58 am # Reply

      Shannon, I could be wrong but when I was looking into it before I believe the 23andme tests for that.

  22. Mo November 10, 2013 at 2:15 am # Reply

    My daughter and I have the double C677T gene mutation. She has already had a DNA test done with Smart DNA 2 years ago but there was no one to translate the test for us. I had no idea what it all meant. Some months ago she was tested again for the MTHFR and found to be positive (which was reflected in the extensive DNA report) We are using your advice and products but my daughter is having continuing problems and I am wondering if you can advise me where I can send a copy of the DNA test result to to get a translation and a protocol to follow. Thank you so much for your help, it is invaluable.

    • rr May 5, 2014 at 6:57 pm # Reply

      hi, there are programs online that allow you to download your info from 23andMe directly to them and they will interpret the info. One is genetic genie. She interprets the methylation genes. It was free but with an optional 10$ donation. This does not interpret everything but the most important methylation and other brain enzymes that are meaningful to know. There are other websites also that interpret other stuff regarding disease risks, but be warned, it’s still kind of confusing if you have no basic knowledge of how this all works. But the genetic genie ones you could show to your doctors and they would understand. PS, if you go through 23andMe, there is a special waiver on the raw data pages that you have to agree to under the BRCA snps in order to see the 2 BRCA gene results (Breast cancer). IF you don’t click on that waiver (it’s kind of hidden and not easy to realize what it is), then those results are not automatically counted when you go to the other sites for interpretation. hope this helps

  23. Sowmya Fesenbeck November 13, 2013 at 11:14 am # Reply

    Dear Dr. Ben
    I have an Autistic son of 6 years and I am new to this journey of Biomedical intervention, I am very interested to test my son for any genetic mutations..Since I live in Stuttgart germany, I can get the tests covered by Insurance run by the state but I need to give a good reason as to why I am asking for it. I understand now aboutMTHFR and can ask for it …but I would like the full mutations to be known like you mentioned as with 23andme.Can you guide me as to how I can validate my request for understanding the genetic mutations with respect to Autism that I can argue for the same. your advice will be greatly appreciated!!
    Thanks and warm regards
    Sowmya Fesenbeck

  24. Terri Rupe February 7, 2014 at 4:07 am # Reply

    Hi Dr Lynch –
    I’ve been reading about the MTHFR testing and was ready to order the $99 saliva test. However, when I went to the website, there was a notice indicating provision of interpretation of MTHFR results has been suspended due to a warning letter received from the FDA on Nov. 22, 2013. The website advises that only ancestry related reports and raw genetic data (without interpretation) will be received. In light of this, is it worth ordering this test right now? Will the raw data provide enough information to be useful to me?

    Thank you!

    • rr May 5, 2014 at 6:58 pm # Reply

      hi, there are programs online that allow you to download your info from 23andMe directly to them and they will interpret the info. One is genetic genie. She interprets the methylation genes. It was free but with an optional 10$ donation. This does not interpret everything but the most important methylation and other brain enzymes that are meaningful to know. There are other websites also that interpret other stuff regarding disease risks, but be warned, it’s still kind of confusing if you have no basic knowledge of how this all works. But the genetic genie ones you could show to your doctors and they would understand. PS, if you go through 23andMe, there is a special waiver on the raw data pages that you have to agree to under the BRCA snps in order to see the 2 BRCA gene results (Breast cancer). IF you don’t click on that waiver (it’s kind of hidden and not easy to realize what it is), then those results are not automatically counted when you go to the other sites for interpretation. hope this helps

  25. M February 28, 2014 at 6:38 pm # Reply

    I would try they offer the test for both variants and can test using either blood or cheek swab.

  26. Kendra April 8, 2014 at 4:47 pm # Reply

    I am a little confused on the testing. If my doctor orders it, does he order a kit, then I take it to the lab? Or is there bloodwork he can order directly? We have a Labcorp nearby.

  27. Maureen Healy April 25, 2014 at 7:51 pm # Reply

    This site needs to be updated b/c “FAQ #8″ is incorrect. I looked up a lab blood center by my home and called to see if they would do the test — they said yes (Quest) but when I got there they said no.

    I called and they said I needed to lookup on their site “Find a Draw Site” for the places contracted to work with them. Of course, I did that but it would have been easier if I got the correct directions initially.

    Thank you for everything but just needs a bit updating.

  28. Wendy May 7, 2014 at 10:25 pm # Reply

    I have many symptoms of MTHFR mutation as well as my siblings. We, however, live in New York and I notice that the testing is not available for New Yorkers. How could we get tested? I’m desperate to see if this is the cause of all my issues!

    • Kathy June 19, 2014 at 8:47 pm # Reply

      Wendy, say the sample did not come from NY

  29. Tammy June 19, 2014 at 2:56 am # Reply

    The link in #14 doesn’t work -(to schedule a consult with Dr. Lynch)

    • Dr Lynch June 19, 2014 at 7:05 am # Reply

      Hi Tammy – I no longer do consults. My apologies. I’ve edited the page. The doctors in the Find a Doctor page are a great resource.

  30. Pauline July 15, 2014 at 1:02 pm # Reply

    Hello Dr. Lynch,

    I live in Toronto, Ontario. I am assuming that this testing is available only in the US? (I know there are many tests that we cannot get done here and that doctors are completely unaware of), my family doctor included!! If I can’t get tested, but suspect I may have the MTHFR mutation, is there general recommendations that I can follow?

  31. sherrie August 26, 2014 at 1:52 pm # Reply

    Can this test be sent to canada?

  32. Barbara Poole December 7, 2014 at 8:38 pm # Reply

    Hello I was tested thru a physician on an HDL Labs cardiac profile. My result was 677T. /TT. This was in 2013. I have many of the issues caused by MFTHR gene mutation. I was tested again by a different physician, not an HDL practicioner, and the MFTHR test was negative. Is this a rare thing or can results vary? Thank you.

    • Dr Lynch December 9, 2014 at 6:56 am # Reply

      Barbara –

      Get tested by the test and re-evaluate.

      • Barbara Poole December 10, 2014 at 3:42 am # Reply

        Dr. Lynch,
        I had the 23& me test when it was first available. I cannot find any mention of MFTHR gene testing in the results. Should I order the test supplied by your website? Thank you so much. Barbara

  33. Patricia December 31, 2014 at 1:37 am # Reply

    I am on the 23andme Canadian website right now and it states that, “23andMe does not provide health reports related to the following conditions:… Methylation analysis of the MTHFR gene”. It says something very similar on the US site. Yet people are apparently getting MTHFR info from 23andme. I’m very confused! Links provided below.

    • Dr Lynch December 31, 2014 at 5:31 am # Reply

      Health conditions are not genetic polymorphism findings – they are different. 23andMe still identifies snps.

    • Lynn_M December 31, 2014 at 6:40 am # Reply

      Patricia and Barbara,

      If you have 23andMe results, you do not need to get the Spectracell genetic test offered by Dr. Lynch. However, unlike the Spectracell genetic test, 23andMe will not spoonfeed you any information about your methylation genes; you have to extract that information yourself. There are two ways to do that. The easiest way, and what I recommend for starting out, is to sign up to get a variant report through either Livewello or MTHFRSupport ( The fee is $20 and they analyze about 200 snps altogether, telling you if you have a homozygous, heterozygous, or no variant snp. Most snps are linked to a site with more information.

      The more advanced method is to go into the Browse Raw Data section of your r23andMe results. After you sign in, your name will appear in the upper right. There is a down arrow to the right of your name. If you hold the cursor over that down arrow, one of the choices that appears in a pop-up menu is Browse Raw Data. Click on Browse Raw Data. In the next screen, you can search for either a gene name or a snp. E.g. If you enter MTHFR in the gene name, about 58 different MTHFR snps will show up, with your results given for each one. Or, you can enter the rs number for a particular snp. E.g. rs1801133 is MTHFR C677T and rs1901131 is MTHFR A1298C. You will then need to figure out yourself, using other sources, what your results mean, and which alleles are the variant ones. While more complicated, using Browse Raw Data allows you to check the status of any of the nearly 600,000 snps that 23andMe now tests for. It was nearly a million snps when the test was first offered.

      • Patricia December 31, 2014 at 4:25 pm # Reply

        Thank you Lynne_M! Very much appreciated! :)

  34. Kim February 4, 2015 at 8:40 am # Reply

    Is there a test that would identify other health conditions in case it’s not MTHFR? Due to health, I am now unemployed and uninsured and afraid to invest in something that may be another desperate attempt for answers. I highly suspect the MTHFR gene mutation, but would feel more secure if other genes were tested in case it’s not. Thanks for the help anyone…

  35. Daniel March 3, 2015 at 10:55 pm # Reply

    I am uneasy about testing my daughter for mthfr…she is young and I am afraid that the results can be used against her when she is an adult looking for health/life insurance. Some people have said it’s not a diagnosis so it can’t be used against her, others have said I should be concerned. Thoughts?

    • Dr Lynch March 4, 2015 at 5:44 am # Reply

      Hi Daniel –

      Hard to say – we cannot predict the future. You have to ask the labs who offer the testing about these details.

    • Barbara March 5, 2015 at 7:36 pm # Reply

      GINA – Genetic Information Nondiscrimination Act of 2008 prohibits genetic discrimination in health insurance and employment in the US but not life insurance

      • Lynn_M March 7, 2015 at 3:59 am # Reply

        Long-term care insurance is also excluded from the prohibition against genetic discrimination.

        For young people, it might be advisable to do genetic testing under a phony name.

  36. Barbara March 5, 2015 at 7:44 pm # Reply

    Dr. Lynch….do you do phone consults? Thanks

  37. Marie March 16, 2015 at 2:10 am # Reply

    Dr. Lynch,
    I am 39 and am a thyroid cancer survivor for about 4 years now. My labs were normal when diagnosed even though I didn’t feel good. I had a mthfr blood test done 2 years ago through quest diagnostics. I started taking b12 sublingual 5000 and the brain fog went away.

    I also have been suffering with anxiety and depression. My father has severe chrohns disease. My sister had the same type of thyroid cancer as myself, but she had hashimotos disease before her thyroid was removed and then a nodule was found on the diseased thyroid. Mine metasasized without having a previous thyroid condition. My other sister has chrohns disease.
    I am finding myself treatment resistant to antidepressants.

    I believe in my heart that I need to do the saliva 23andme test to check this again!
    Do you believe that this one test I had 2 years ago can be false?

    Thank you sooooo much!

  38. Melissa March 18, 2015 at 10:58 pm # Reply

    Hi Dr.,
    I recently got my DNA results back from a commercial test (AncestryDNA) and uploaded them to Promethease. I am homozy. for C677T, and for V158M, and H262H. Not the good kind of homozy. My A1298C is “normal”, my C699T, and N212N are too. I am hetero for the VDR’s and the MAO-A. I am also hetero for MTR and A664A.
    I have had notable fatigue all my life. I have lived a very full and active life, but I’m guessing that is due to my lifestyle, which was very healthy foods, and lots of exercise. I recently had a bad bout of depression and long period of stress which completely took me down the health ladder. I have been severely fatigued for a month now, and I have major brain fog and concentration issues. I have started on a methyl correcting program including active b12, a methyl correcting multivitamin, and supplemental methyl. However, I am still experiencing these symptoms, even though my mood has been better. I’ve been on the correcting supplements for a week and a half. Should I be feeling anything more yet, and can you see anything I need or am doing wrong?


  39. Danielle April 10, 2015 at 5:33 pm # Reply

    my husband and I have been trying to have a baby for 5 years but have had miscarriages and unexplained fertility. We have had numerous iui’s done. ALL the testing we have done came back normal. My question is we have had genetic testing done and it came back normal for both my husband and myself. I just came across some research on MTHFR. It got me wondering. My question is when we did all the testing and what not…..did they test for this? Is this included in any of the testing for infertility?

    • Aron Choi April 13, 2015 at 4:40 pm # Reply

      Danielle, check out this post on MTHFR and Pregnancy . MTHFR is typically not screened with standard genetic testing for pregnancy.


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