Prenatal Supplementation: Optimizing your Future Child

Prenatal Supplementation: Optimizing your Future Child  

    • General supplement recommendations for those who are pregnant, regardless of the MTHFR mutation
    • Provides insight into which supplements are needed while pregnant….and…why.
    • Provides dietary suggestions to increase calcium and magnesium levels.
    • Explains the importance of why nutrients are so critical during pregnancy
    • Provides specific supplement recommendations along with suggested amounts and when to take.

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Supplements to consider (in addition to a healthy well-rounded diet):

  1. Optimal Prenatal: provides a blend of active folates along with other key nutrients
    1. Optimal Prenatal Protein Powder: provides Optimal Prenatal PLUS a complete protein blend. Two great flavors to choose from. Make a prenatal smoothie instead of swallowing pills. This is what I use about 4 times a week for my breakfast each morning. No – I am not pregnant ;) but I am compound heterozygous MTHFR and feel great after using this.
  2. Active CoQH: provides 50 mg of pure ubiquinol in small easy-to-swallow gelatin capsules. Soy free. Best to take with food anytime of day. Consider 1 daily.
  3. Sublingual Active B12 with Methylfolate: provides 800 mcg of methylfolate and 1000 mcg of vitamin B12 (800 mcg of methylcobalamin and 200 mcg of adenosylcobalamin) in a small sublingual tablet. Consider placing 1 tablet under the tongue in the morning upon rising and another 30 minutes before lunch. Your physician may desire you to take 2 tablets under the tongue twice a day. Vegetarian.
  4. L-5-MTHF: provides 1 mg of methylfolate as Metafolin. Take as directed by your healthcare professional. Useful to increase your methylfolate levels incrementally if higher amounts are needed or recommended by your physician.
    • OR L-5-MTHF Lozenge: provides 1 mg of methylfolate as Quatrefolic in an easy-to-deliver lozenge. Lozenge may be broken into smaller pieces for smaller doses.
  5. Optimal Vitamin D Liquid: provides 2,000 IU of vitamin D3 in a pure base of extra virgin olive oil. Kosher ingredients. Vegetarian. Consider taking 3 drops daily or 21 drops once a week. Recommended to take 6,000 IU of vitamin D3 daily while pregnant and breastfeeding. Have your physician monitor your vitamin D blood levels.
  6. ProBiota 12 Powder: provides 50 billion beneficial bacteria in 12 strains in a great tasting powder that is easy to tolerate. Simply take 1/8th teaspoon and place directly into your mouth after dinner nightly.
  7. Chewable Cal/Mag Plus D: provides 25% of daily calcium and 25% of daily magnesium per chewable tablet. Consider chewing one with lunch and dinner.
  8. Optimal Chia Seeds: provides additional food-based calcium, magnesium and trace minerals – and protein – in a very healthy form. Consider making Chia Seed Gel in the evening and taking 1 tablespoon between meals to help absorb toxins and encourage healthy bowel movements.
  9. Optimal Vitamin E: provides 400 IU of mixed tocopherals in an easy-to-swallow gelatin capsule. Vitamin E is an excellent antioxidant and also supports healthy blood flow.
  10. Optimal Krill Oil: provides 12 mg of astaxanthin along with a lower amount of EPA/DHA that crosses the blood-brain-barrier as it is in a base of phosphatidylcholine. Consider taking 1 gelatin capsule daily anytime of day with some food.
  11. Optimal Fish Oil: provides potent amounts of EPA/DHA in the triglyceride form which is better absorbed than the ethyl ester forms. Consider taking 2 capsules daily with a meal anytime of day.
    • OR Optimal Fish Oil Liquid: provides EPA/DHA in an excellent tasting liquid that may be added to smoothies or taken straight with some food. Consider taking 1 tablespoon daily.
    • OR Optimal DHA (Vegan): provides 400 mg per serving of vegan DHA which is non-GMO. Also provides phospholipids.
  12. Optimal PC: For those having methylation deficiencies, especially MTHFR, BHMT or PEMT, consider a phospholipid complex which provides phosphatidylcholine and other key phospatidyl derivates. Choline deficiency is quite common in pregnant and breastfeeding mothers. We do not want choline deficiencies as it is a critical nutrient for cognitive development.

Prenatal Multivitamins:
There are very few prenatals that meet a high enough standard for me to recommend. The following are the multivitamins I do recommend for now:

  • Xymogen Prenatal Essentials: pretty good overall but has a fair amount of iron. Call 800-547-9812 to order this. (Here is information on it).
  • Optimal Prenatal: provides 800 mcg of methylfolate and folinic acid for best folate support. Using only methylfolate in a prenatal is not recommended. This is iron-free.
  • Chewable Optimal Multivitamin: this has no iron, has a nice taste and requires a woman to take additional methylfolate during pregnancy and breastfeeding.

Disclaimer: The information and product suggestions presented here are merely suggestions for you to consider. This information is not a prescription, treatment or diagnosis. Follow the suggestions and use the suggested supplements at your own risk. It is highly recommended that you discuss this information with your physician. Always seek the advice from your healthcare professional.

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155 Responses to “Prenatal Supplementation: Optimizing your Future Child”

  1. Cassie January 20, 2012 at 11:08 pm # Reply

    Some doctors are recognizing now that LMWHs and/or heparin are necessary with MTHFR. If someone were taking either of these during pregnancy, would you change any of your recommendations above for supplements. In other words, would any of them conflict or would you need more of some b/c of being on anti-coags?

    • Dr Ben January 20, 2012 at 11:24 pm # Reply

      Cassie –

      Great question.

      You may have to reduce the Optimal Fish Oil down and identify a pure DHA supplement. Optimal DHA by Seeking Health is a vegan-based pure DHA supplement which is in a base of phospholipids.

      All the other nutrients are fine to take while on blood thinners – including Optimal Krill Oil. There is not enough EPA/DHA in Optimal Krill Oil to pose a problem for most women.

      Definitely talk with your OB/GYN and physician and obtain their thoughts on the matter.

  2. Christa January 21, 2012 at 5:22 pm # Reply

    Ok so it is ok to take NeevoDHA plus the Optimal Chewable Vitamin together? I also want to take the Probiota 12 powder.

    I was diagnosed with a vitamin d deficiency and took 50,000 mg per week for 12 wks. It hardly did anything. Should I take an additional calcium and d3 supplement in addition to all the above?

    Thanks.

    • Dr Ben January 23, 2012 at 6:30 am # Reply

      Christa –

      It is ok to take the Optimal Mutltivitamin Chewable and the NeevoDHA together. The ProBiota 12 Powder is also fine to take – and highly recommended.

      The question I pose is what form of Vitamin D3 were you taking and why didn’t your levels rise? I highly recommend you try taking Vitamin D360 and taking 6,000 IU to 10,000 IU a day which is 3 to 5 DROPS. Make sure you have your doctor measure your vitamin D levels and discuss this dose with them. The 6,000 IU a day is totally fine while pregnant. The 10,000 IU is also likely ok but it is pushing it.

      You should take an additional Cal/Mag supplement while pregnant. This will help the vitamin D3 absorption and also help prevent calcium loss from your bones – and leaching of lead from your bones as well. Consider chewing 2 tablets of Calcium Magnesium Plus D3 Chewables twice a day – breakfast and dinner or lunch and dinner or anytime of day.

      I also highly recommend the Active CoQH and Optimal Krill Oil – to truly support your developing child’s neurological system.

      • Christa January 24, 2012 at 12:08 am # Reply

        The vitamin D deficiency has been going on for a long time. In the beginning I also had anemia. Ferritin and iron was low. Anemia seems to be better according to lab results.

        Year 1-vitamin d-sub for Drisdol 50,000 units
        Year 2-D3-50-BIOTECH
        Year 3-vitamin d-50,000 same as above

        Today, 1-23-12, doc called to say vitamin d is extremely low again. What is going on?

        To this day, for three years, my vitamin d levels will not increase. It is a mystery that I do not like. I live in FL for goodness sakes with lots of sun. No one can explain it.

        They were going to call in a prescription for 50,000 u. I told them that I cannot because I am pregnant. So waiting on return call about that.

        I will take this information to my doctor and see what she says. Thanks for your advice and wisdom.

        • Dr Ben January 24, 2012 at 1:44 am # Reply

          Christa -

          Drisdol is vitamin D2. Not a good form of vitamin D.

          I am suspecting too high of a dose of D3 taken at one time and also low stomach acid or bile secretion PLUS iron deficiency. If you take so much vitamin D3 at once vs a smaller amount each day, that may help increase your vitamin D3 levels.

          Read the study on vitamin D3 and iron deficiency. They are linked.

          Iron deficiency is linked to poor vitamin D3 absorption. Consider taking 1 capsule of Optimal Iron Plus Cofactors daily on an empty stomach – first thing on rising.

          This is why I recommend you consider taking 10,000 IU of Vitamin D3 daily in the form of liquid vitamin D3. Very well absorbed and you place it directly on your tongue.

          • Christa January 24, 2012 at 2:05 am #

            Thanks for all your help. I am going to try and find a doctor to listen and believe me. My progesterone levels are at 8.1 and my hcg @ 600 at 5w1d. It doesn’t look good right now. This will be my 4th miscarriage, but what I have learned in the last month about MTHFR and other factors, I believe there is hope for the future. I just need to find a doctor who will truly listen and believe my symptoms.

        • Jen Aliano August 6, 2012 at 4:52 pm # Reply

          Hi Christa,

          I just wanted to note that Magnesium deficiency can often be the cause of vitamin D levels not rising despite supplementation. There are several other cofactors. Here is some easy reading you might want to consider: http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-cofactors/

          Thanks Dr. Ben for this post! Great information!!

          For those of you who would like to ‘DO’ something about the major vitamin D deficiency epidemic that affects a majority of pregnant women, please also check out http://www.grassrootshealth.net/daction-poc. The information that Dr. Ben and very few others provide about the necessity of vitamin D during pregnancy, especially, is priceless. We (GrassrootsHealth) are trying to make this information mainstream and available to ALL pregnant women.

          Thanks,
          Jen

  3. Ann January 23, 2012 at 6:47 pm # Reply

    Thank you for this. I had sent a message to the “contact us” page, but realized that was probably the wrong place. Anyway, I had two miscarriages, got diagnosed Compound Hetero MTHFR. I took 2 folbic, Neevo, and Baby Aspirin and about 5 grams of Fish oil a day. I had a healthy baby in August. Now I’m trying to get pregnant again, and after reading your website, I’m thinking the Folbic may be the wrong thing to take (even though it seemed to work) and I’m afraid the Neevo by itself isn’t enough. I just ordered the L-5-MTHF and the Sublingual Active B12 with Methylfolate. I’m currently taking the original (Pink Pill) Neevo, CAL/Mag/vitd, Vitamin C, and about 2.5 grams of Fish Oil, and a probiotic. Would it be safe to add both supplements, making my L-MTHF 2,800mcg. or should I just start with the B12, making my L-MTHF only 1,800mcg? I called PamLabs, and they told me the B12 in the pink Neevo is not the active form so I’m assuming it’s doing nothing for me. I’d love to know your thoughts. Thanks!

    • Dr Ben January 23, 2012 at 11:13 pm # Reply

      Hi Ann –

      Folbic contains standard folic acid, poor form of B12 and B6. Given that 2 x Folbic contains 5 mg of folic acid and L-5-MTHF is much more potent than folic acid, I would start out with the Active B12 with Methylfolate and Neevo for now. You are also getting the active B12 form of methylcobalamin vs cyanocobalamin which is going to make your methylation cycle work much better than if it was using cyanocobalamin.

      I would add the Active CoQH and Optimal Krill Oil.

      I would also add in the Optimal Multivitamin Chewable as it contains a complete B complex along with complete minerals – which you need and so does your little developing one. Neevo does not contain comprehensive minerals or B vitamins.

      Make sure you take the Vitamin C at least 1 hr away from Neevo and the Sublingual B12 with Methylfolate. Vitamin C in excess of 250 mg can destroy vitamin B12.

      Make sure you also take about 6,000 IU of Vitamin D3 daily.

      I know it may seem like a lot of nutrients, but we are not only trying to prevent miscarriage – we are trying to provide your developing child with the best genetics possible. That is my ultimate goal.

  4. mrsjukian January 27, 2012 at 11:50 pm # Reply

    Hi Dr. Ben,
    I am homozygous C667T, and also have Hashimoto’s hypothyroiditis. Recently went gluten free after reading a great book called “Why do I still have thyroid symptoms when my lab tests are normal”. Have had 3 miscarriages, all under 6 weeks.

    My holistic doctor is recommending that i get nutritional testing done with SpectraCell. I have had this done two years in a row, but recently my thyroid doctor scoffed at it. Do you think this test is good enough to find out what nutrients i’m deficient of, or is it a waste of money?

  5. Dolores February 25, 2012 at 12:12 am # Reply

    Greetings Dr.Ben ~ I’m homozygous C677t and about to see a specialist for supplementation layout .. How long do u suggest we implement these supplements before we TTC again. Thank you. We look forward to helping others with a success story and a baby blessing very soon ;)

    • Dr Ben February 25, 2012 at 12:17 am # Reply

      Dolores –

      I recommend you do most of those suggestions – if not all – even while you are pregnant ;)

      Look forward to hearing your success story and seeing a photo!

      • Dolores February 25, 2012 at 12:29 am # Reply

        Thank u kindly for your help! Definitely hope to continue throughout va whole pregnancy — just curious if you suggested we run the supplements for a period of time before we start trying to,conceive again ?! I’ve heard various opinions 30-100 days of shops in system prior to getting pg again. Thanks again. Havea great weekend

  6. April February 27, 2012 at 7:06 pm # Reply

    Dr. Ben,

    I am A1298C Homozygous. I’ve had 2 misscarriages, one successful pregnancy and I’ve had a PE. I’m currently pregnant and taking Lovenox, Metanx, Biotin, Iron, and a chewable calcium supplement. I’m thinking about replacing my calcium supplement with the Calcium and Magnesium supplement.

    I’m on a limited budget. Unfortunately I cannot afford all of the supplements you have suggested, so I need to pick and choose. Which supplements are the most important that you think I cannot go without?

    • Dr Ben February 28, 2012 at 7:17 am # Reply

      April –

      Tough question for me as I’ve already thought this through to be as limited as possible. I will do my best but I truly don’t like limiting it as it requires a multifaceted approach to optimizing pregnancy.

      Why you taking Biotin?

      I would choose:
      - Optimal Fish Oil
      - ProBiota 12
      - Cal/Mag supplement
      - D3
      - Optimal Multivitamin chewable

      Probiotics are huge as are the oils and comprehensive multi.

      Have your doctor measure your ammonia levels. If they are elevated, then you need to reduce your protein intake a little – not much – and to also supplement with BH4 – which can be quite expensive.

      • April February 28, 2012 at 6:01 pm # Reply

        I’m taking Biotin because my doctor suggested it. My hair was falling out and my nails were weak. It seems to be helping.

        I appreciate you narrowing it down for me. I can at least start out with the supplements you listed. Thank you for you help.

        • Dr Ben February 28, 2012 at 6:03 pm # Reply

          April –

          Makes sense for the biotin.

          Do have your doctor check your thyroid:
          - TSH
          - T3
          - T4
          - anti-TPO
          - anti-TG

          • April February 28, 2012 at 6:16 pm #

            I know I just had my thyroid checked. I will see if I can get a copy of my test results. Thanks for the suggestion.

  7. Victoria February 29, 2012 at 10:33 pm # Reply

    Dr. Ben,
    I have a few questions for you:
    I have had 2 misscarriages in the past 4 months. One at 6 weeks and the other was discovered at my 8 week u/s and the babies only measured at 6w3d. I asked my doctor to test me for clotting factors because I could not undergo another loss. My blood work came back positive for MTHFR Hetro C677T and A1298C. My doctor said I will start Lovenox the next time I am pregant. I am taking Citra Natal 90 DHA prenatals. After researching some I asked my doctor to put me on Folgard also and she is going to call that in for me. Do you have any other suggestions for me as far as a pregnancy goes with this routine of Vit’s and lovenox? She also said I can supplement both Vit’s to bring my B6 to 100mg/day and B12 to 250mcg/day. All of this was due to my request, she openly admitted she knows very little about MTHFR.
    Second question, I am going to make an appointment with an internist to discuss this condition and how I need to treat myself when I am not pregnant. Should I ask for a homocystine level to be done? And if so, should this be done before I start the prenatal and folgard routine? What are the best treatments for this mutation and what is my risk with having it? I am worried because no doctors I talk to know anything but what I tell them I have read online and every article is different. Please help, I am desprate!! Thank you and bless your heart.

    • Dr Ben March 1, 2012 at 8:09 am # Reply

      Victoria -

      Please listen to the podcast here on this article.

      I also encourage you to read the article in full. Many of the questions you asked are answered here.

      I highly caution you about taking 100 mg of B6 daily – that is a lot – especially if you are taking the active P-5-P form.

      Folgard is not my recommended med of choice for MTHFR as it does not contain the right nutrients in my mind. Metanx is the best. However, both of these contain a lot of fillers and garbage.

      Here is the other ingredients found in Folgard:
      Other ingredientes: dicalcium phosphate, microcrystalline cellulose, corn starch, sodium starch glycolate, hypromellose, stearic acid, titanium dioxide, magnesium stearate, sodium citrate, polyethylene, glycol, citric acid, riboflavin, FD&C Blue#1 Lake, Silicon Dioxide, polysorbate 80, sodium benzoate, sorbic acid, carnauba wax.

      Homocysteine level can be ordered – sure. Even if it comes back normal, you have to take precautions.

      Also test your thyroid and female hormone levels – and testosterone. Progesterone must be checked now and once pregnant. Progesterone suppositories may be needed.

      Given your history of miscarriages, getting up to 2 mg or so of methylfolate daily would be ideal. Research states about 4 mg of folic acid to women with recurring miscarriages – but that is folic acid – not the most active form which is methylfolate.

  8. Jennifer March 2, 2012 at 7:52 pm # Reply

    Hi Dr. Ben,

    Would you recommend these same things for any woman of child-bearing age? My husband and I are not necessarily trying to conceive at the moment, but expect to be in the next couple years.

    Our daughter was stillborn at 37 weeks about a year and a half ago. After some testing, my perinatologist told us that I am heterozygous for the MTHFR gene and I also tested positive for all four anti phospholipid antibodies.

    After reading some of your information and listening to this podcast, I feel incredibly uneducated about my diagnoses.

    Right now I am taking a prenatal vitamin called Brainstrong and Folgard, but I don’t think that these two things are necessarily the right things for me to be taking. I want my body to be at optimal health for when we really do try to conceive again.

    Thanks for all of this information. It is so great to be able to read more about it. After reading this, either I didn’t know which questions to ask, or my doctor is not very educated about this mutation. Thanks very much for your time.

    • Dr Ben March 3, 2012 at 12:16 am # Reply

      Jennifer –

      Which MTHFR mutation you have? 1298 or 677?

      • Jennifer March 3, 2012 at 6:25 am # Reply

        To be honest, I don’t know. I will get a copy of my records on Monday. My doctor didn’t tell me a lot about it. Both my regular doctor and perinatologist gave me the impression that this was not something that would affect me other than when I’m pregnant. I’m feeling very misinformed. I will get back to you as soon as I know more. Thanks again for your time! :)

  9. Thera March 28, 2012 at 5:57 am # Reply

    I am homozygous c677t with advanced endometriosis and am experimenting with the supplements you recommend to find the right balance. I have recently gone gluten free and reduced dairy. My ob/gyn wants to put me on daily hcg shots to try to help me conceive. I’ve taken it before as a trigger shot with clomid but not on a daily basis. He doesn’t seem to know a lot about mthfr and I don’t want to do something that will make me worse off, I have a strong chemical sensitivity. Do you think that will interact with this condition?

    • Dr Ben March 28, 2012 at 6:15 am # Reply

      Thera –

      In my opinion, not a good idea to force conception right now. The likelihood of a miscarriage is too great with MTHFR and endometriosis. I say work on eliminating the endometriosis through lifestyle, diet and supplements and also address the MTHFR mutation.

      I can help you with both.

      I highly recommend a one hour consult to address both of these – along with the chemical sensitivity. Please call 800-547-9812 to schedule a consult. You may RSVP your consult here.

      I really want you to get pregnant naturally and develop your child healthfully for 9 months. The chances increase tremendously when the right things are addressed.

      • Thera March 29, 2012 at 7:43 pm # Reply

        Thank you, I agree as well. I would like to get my body as healthy as posible to be able to conceive naturally. I am going to schedule a consult, I just want to get a few more tests blood tests done first and maintain my new healthier diet and suplementation so I have a more comprehensive look at any obstacles I may have. Do you recommend Sun chorella as an additional nutrient to take? It looks like it is full of natural vitamins, algae, protein and is detoxing. I just didn’t know if there was anything in it that would interfer with MTHFR or the other supplements. Thank you!

  10. Amanda May 10, 2012 at 1:47 am # Reply

    I just found out I’m expecting and am already on most of your prenatal supplement protocol (coQH, krill oil, fish oil, vit D, probiotic, cal/mag, chia) but am still taking my one a day that contains food derived Bs (new chapter). I was also taking an active B complex (THORNE basic B complex), 1000mg sublingal methylcobalamin, and 1mg L-MTHF (THORNE) Anyways, my question is that I have been having terrible side effects of anxiety, depression, and heart palpitations when I take any of the active Bs. I no longer take them and want to try slowly tapering my way back up, but I’m worried about my pregnancy and want to get back into taking them as soon as possible. Would you still recommend me stopping all active B supplementation for a week or two and then easing back in? Is perhaps the actual supplements I’m taking causing some of the problem? Any input would be much appreciated! I want to do what’s right for my baby but I don’t want to have to fall into a pit of despair to do it! My mutation is single copy 677.

  11. Leslie May 20, 2012 at 6:56 pm # Reply

    Dr. Ben,

    I am Heterozygous for both C677T and A1298C and Factor V Leiden. It took 2 miscarriages to be diagnosed. I then took Folgard, Lovenox, over the counter prenatal, calcium, fish oil, and Juice Plus and had a wonderful pregnancy without complications. Our daughter is very healthy.

    After having her I was diagnosed with a thyroid goiter, had it half my thyroid removed and it the large goiter was benign but they did find a very small growth of papillary cancer. (maybe due to excess folic acid levels?)

    So now we are planning to get pregnant again. The above supplement list is very extensive (not to mention expensive) and not sure about the quantities on this list. Ultimately I want to know what I should take. I know how you feel about Folgard and was looking at changing to Metanx, but also thinking I should just stick to this list and not take a perception supplement or the Juice Plus. How do you feel about Juice Plus?

    Thank you for your advise and information.

    • Dr Ben May 21, 2012 at 5:55 am # Reply

      Leslie –

      I am not sure about Juice Plus. It may be good as a supplement – but is definitely not the only thing you should be taking.

      A supplement containing L-5-MTHF is as good as a drug containing L-5-MTHF as both are Metafolin. I am not fond of any prescription drug with L-5-MTHF (methylfolate) as all drugs contain fillers, flow agents, colors, etc.

      You are right – Folgard is not the best.

      I am glad that you carried to term for your previous pregnancy – that’s awesome :) I do caution you with folic acid and I am glad you are aware of that as well now.

      Methylfolate as L-5-MTHF (metafolin), methylcobalamin and vitamin B6 are truly needed for those with MTHFR mutations.

      Folinic acid is also useful – which is found in leafy greens – and some supplements.

      • Angela July 8, 2012 at 10:57 pm # Reply

        Hi Dr Ben – what is your opinion of people with Histadelia as this appears to be linked to the MTHFR in regards to not being able to methylate properly both Folate and B12.

        • Dr Ben July 12, 2012 at 12:12 am # Reply

          Angela –

          Absolutely linked – no question in my mind at all.

  12. Angela Perez July 12, 2012 at 4:55 pm # Reply

    Hi Dr. Ben,

    I have some questions. I was recently pregnant and lost the pregnancy at 9 weeks. I found out 2 weeks prior that I had MTHFR one of the C677T mutation and one of the A1298C. I am 42 years old.I have one son who is 13 years old and that pregnancy was fine. I did not know about the MTHFR.
    We are wanting to TTC again soon.
    My Dr. has me taking this: NeevoDHA, 1MG of folic acid, 1 81mg asprin, and 1 D3 1000iu.
    My question is I want to switch the folic acid I am taking now to the correct kind. I am going to order the L-5-MTHF 1000 that you recommend here. I wanted to know how much you thought I should be taking in addtion to the NeevoDHA?
    Also, I was thinking about the Chewable Optimal Multivitamin but wanted to double check that it’s ok to take with the NeevoDHA? I had thought that the Neevo and all I needed but after looking at your site I am thinking it doesn’t.
    I am looking for a new OBGYN although I love mine, I need one that knows a bit more about MTHFR. Mine did tell me he would put me on Lovenox if I get pregnant.
    Any advise would be appreciated!!

  13. Jourdan July 12, 2012 at 5:50 pm # Reply

    Can you clarify your thought about lovonox. I think my Peri basically prescribed it as a safety measure. Will your supplement protocol negate the need for lovonox? I’m also on folgard but headed to health food store right now to get the items you suggest instead.

  14. Jennifer July 18, 2012 at 9:58 pm # Reply

    Hi Dr. Ben,

    Thank you for these recomendations for pre-natal supplements. Can you provide recommendations for proper supplementation prior to conception? (with the hopes of conceiving sometime in the near future?) I have a single copy of C677T and am hoping to conceive again soon – we have had 4 miscarriages in the last 4 years (and one healthy baby during that time as well). Thanks – I’d really appreciate knowing what to be taking now, before pregnancy.

    • Dr Ben July 25, 2012 at 7:31 am # Reply

      Hi Jennifer –

      I would take the above to prepare yourself prior to getting pregnant – and then maintaining it. Finding a great prenatal right now is also recommended.

      • Jennifer July 26, 2012 at 2:35 am # Reply

        Thanks Dr. Ben – I have looked at the different prenatals you recommend, and as you mention for your first two choices, I do have a hard time with iron, so I took a look at the kids’ optimal multivitamin. Typically, I also have a hard time swallowing pills during pregnancy, and 6 a day sounds like a lot. I was looking at your chewable multivitamin, but noticed you do not include that on your prenatal recomendations list – is there a reason this should not be used as a prenatal?
        Thanks again,
        Jennifer

        • Dr Ben July 26, 2012 at 4:19 am # Reply

          Hi Jennifer –

          The chewable multivitamin is a good alternative – good point. I want you to make sure you are getting enough methylfolate from other supplements though – such as Active B12 with Metafolin or the L-5-MTHF.
          I will update my list to include it.

          The Kid’s Optimal Multivitamin uses quite small capsules – much smaller than the average multivitamin so that is one bonus ;)

          Make sure you take any multivitamin with meals.

          In health,
          Dr Ben

          • Jennifer July 27, 2012 at 6:13 pm #

            Dr. Ben,

            I just looked more carefully at the chewable vitamin ingredients, and am wondering if perhaps it may not be as good a choice as the others, as it contains licorice extract, which according to some herbal sites is contra-indicated for pregnancy. I’m not sure how you feel about the use of herbs during pregnancy though.

  15. Erin July 24, 2012 at 2:05 am # Reply

    My husband and I have been trying to conceive for the past 5 years (no babies yet). We have had 3 miscarriages in the past 12 months all different but all were lost under 11 weeks. I just started to see a RE this month and he had me do a lot of blood work. Out of that I found out that I am compound heterozygous (1 copy of 677CT + 1 copy of 1298AC). My homocysteine level is 8.6

    My RE put me on NEEVO DHA per my request to try to get the active folate (started 3 days ago) plus 3mg of Folic Acid (have not started due to my concern over synthetic and not active folate). After listening to your podcast it seems as though I should be taking all of your suggestions from Active CoQH down to the Optimal Fish Oil.

    My question right now is do I also continue to take the NEEVO DHA along with all of this or would I stop the NEEVO DHA and only take your #1-9. Also I am not currently pregnant we are trying to conceive so would the amounts of what I should take change?

    Do you have thoughts on taking a baby Asprin and progesterone (after ovulation) daily trying to conceive and throughout a pregnancy? My RE also recommended that too.

    Any information would be greatly appreciated.

    • Dr Ben July 25, 2012 at 6:27 am # Reply

      Hi Erin –

      I am not a fan of synthetic folic acid at all. It is an archaic recommendation that is fraught with issues. Standard medicine highly recommends it to this day and will likely continue to do so for another 10 yrs sadly. There is so much data pointing to the risks of excessive folic acid yet nothing is done about it.

      Neevo DHA is a useful basic and incomplete prenatal – however – it does have its place and I am glad doctors are using something.

      I am very oriented towards prevention so my recommendations are more likely ‘overkill’ to some docs and midwives; however, if you think about it, as future parents, it is our responsibility to provide the healthiest DNA and environment as possible for our developing children – and our future grandchildren. So – in short – yes – I recommend #1 – #9. This is not a long term thing where you have to take all this forever – but it is designed to optimize your health and your babies health as much as possible.

      I personally wish i knew 1/20th of what I know now before my wife and I had our three boys. Thankfully our boys are healthy but I wonder how much better off they would be if we had optimized our health.

      If your progesterone levels are low or low normal, taking more progesterone is likely needed. Taking a baby aspirin is also a good idea.

      I am passionate about this area of medicine and am happy to discuss with you more in depth about how to optimize your health for pregnancy. There is a lot more to it than what is in this article above and during a consult, I can help direct you better should you need it. Please call 800-547-9812 should you want to schedule a consult or you may RSVP online as well here.

      • Erin July 25, 2012 at 7:20 am # Reply

        Thank you Dr Ben for your quick response. I was actually reading more information on your site when you left your response haha. I so appreciate all the information you have made available regarding MTHFR. Thank you!

        I so appreciate all of your feedback and I will be talking with my husband to see if I can make a consult apt with you.

        In the meantime if I understand correctly I should continue taking NEEVO DHA plus your #1 – #9 correct?

        If my RE wants me on 4 mg of folic acid (total) would it be safe and normal for me to take 4 mg of the active folate (total) instead? Harm in taking too much active folate?

        Being that I am Compound Heterozygous as well would it be a good idea for me to be on Asprin 81mg daily (for the rest of my life or just while trying to conceive after ovulation and during pregnancy)?

        Thanks in advance!

      • Angela July 25, 2012 at 8:23 am # Reply

        Dear Dr Ben. I am a nutritional therapist in the UK and thanks to your site I am now recommending that a lot of my clients who are having multiple miscarriages go for the MTHFR test. I have really good links with the Nutricentre in London, one of the best supplement company in the UK. I will have a word with them about stocking your products. I have also spoken to a company I use ‘vital greens’ who have formulated a wholefood supplement to look at replacing folic acid and cynocobalamin in their products with active methyl folate and methyl cobalamin. It turns out their nutritional therapist in their London office has just tested MTHFR C677, so it might sway them more! What I wanted to know is do you send internationally, if I send a few clients your way for the supplements? Thanks in advance so much for all your fab information. Also have you thought about practitioner podcasts, this information is so vital! Best wishes Angela.

        • Dr Ben July 26, 2012 at 5:59 am # Reply

          Angela –

          Thank you for your kind words and support. Much appreciated ;)

          I am glad you are recommending the MTHFR test – excellent to hear!

          My company, Seeking Health, does ship worldwide – absolutely. We use FedEx International and also the USPS International services. I thank you for any and all referrals – they are very much appreciated. Seeking Health is what allows me to continue my research – so without Seeking Health, my time to research would be seriously limited.

          Thank you for talking with Nutracentre in London. That is excellent!

          Practitioner podcasts – I would love to do that and have plans on doing so – just a question of getting organized and time.

          How would you like the practitioner podcasts to be? What are your thoughts? Format?

          Best
          Dr Ben

      • Angela November 10, 2012 at 1:25 am # Reply

        Hi Dr. Ben!

        Thank you so much for all of this useful information! It is a lot to digest but thanks to you I am understanding this gene mutation a little bit better (compound hetero. MTHFR – Homocysteine Level at 6.9). I am 5 weeks pregnant and started with some of your recommendations several months ago. I too am on a budget so I am currently taking your Optimal Chewable Vitamin, Calcium Mag. D3, and Sublingual B12 with Folate.

        I had my first prenatal appointment today and shared my information with my OBGYN and she didn’t know anything about MTHFR and she didn’t think that I was taking enough Folic Acid…with your Chewable Multi and the Sublingual B12 I am taking 1200mcg. She wants me to take a standard Folic Acid in the amount of 4g. I didn’t want to argue with her but I tried to explain everything that I have learned on your website. She said that she would feel better if I were to take the 4g in addition to what I am taking and the extra amount wouldn’t do any harm.

        I refuse to take the synthetic folic acid after what I have learned from your site. Instead, I just ordered your L-5-MTHF supplement. Would I then take 4g of the L-5-MTHF? Please let me know what you believe is the best dosage.

        I really wish that I could listen to your podcast but I have a slow internet connection. Is your podcast in an article form?

        Thank you again for your concern and dedication to MTHFR!

        Angela

        • Dr Ben November 10, 2012 at 7:42 pm # Reply

          Angela –

          The multivitamin I really like for pregnant women is by Xymogen – Prenatal Essentials.
          Please switch to that from the chewable Optimal Multivitamin – ideally ;)

          The best thing to do is to evaluate your current methylation status and optimize your nutrients based on that.

          If that is not possible due to budget, then you need to assess how you are feeling and follow your doctor’s recommendations – or find a doctor that you feel is more knowledgeable in this area.

          If you feel good taking what you are doing, then you may try increasing the amount of b12 and methylfolate. If you still feel good on a higher amount, you may maintain that. If you feel badly or experience symptoms, then you need to reduce the amount. Of course, listen to your doctor and find one that is knowledgeable in methylation.

          Folic acid is synthetic and hard for you to process it due to MTHFR. If you take the b12, methylfolate and folinic acid – which is found in the Prenatal Essentials – then you providing your body and baby key nutrients for methylation.

          If your OB doesnt know anything about MTHFR, then the recommendation of taking 4 mg of folic acid makes sense because of the lack of knowledge.
          4 mg of folic acid is the standard protocol for those with recurrent miscarriages yet it not appropriate for all situations; and, in my opinion, not recommended due to new knowledge of how prevalent MTHFR mutations are.

          My podcast is not in article form – apologies. I am writing a book now on MTHFR – slogging through it :) but I will get it done.

          Excess folic acid can do harm – there is research showing that excessive folic acid can do harm. But of course – so can not enough folate.

          Remember to maintain your nutrients during breastfeeding.

          Please understand that the information provided is simply that – how you apply it is at your own risk.

          • Angela November 10, 2012 at 11:18 pm #

            Hi Dr. Ben!

            Thank you for the quick response. That prenatal looks fantastic accept for the fact that it is high in iron and I have difficulty with iron. I actually took a prenatal with my last pregnancy that didn’t contain any iron.

            I feel good taking the optimal chewable, active b12, and calcium mag. D3. So far it has been agreeing with me and I have been taking it since August. I only take 1 tablet of the Active B12 daily. I am uneducated when it comes to vitamins and their daily values. I ordered your L-5-MTHF to try and add a little bit of that at a time instead of more of the Active B12 due to my concern that I would be taking too much B12. In your opinion, which is better for me to add a little bit more of…the Active B12 or the L-5-MTHF?

            Thanks so Much!

            Angela

            P.S. – My father also has MTHFR and I have told him to switch from the synthetic Folic Acid to your Active B12 and he loves it!!!

  16. Jordan July 25, 2012 at 4:20 pm # Reply

    I am 18 weeks pregnant and a few weeks ago my doctor called me saying that I have mthfr. She put me on a different prenatal with more folic acid. Everything that I read about says that I should be doing more. Does this mean I don’t have it as bad or something? Or should I be questioning my doctor?

  17. Katie July 25, 2012 at 9:01 pm # Reply

    I was diagnosed Compound Heterozygous after I lost my son at 20 weeks. Unfortunately, my doctor convinced me the MTHFR mutation was a non-issue (both for my son’s death as well as any future pregnancies). I went on to lose another baby at 7 weeks shortly thereafter. I have since switched to a high-risk OB who takes MTHFR mutations seriously, treating with baby aspirin and eventually Lovenox when I become pregnant again. However, he is not very knowledgeable about B vitamins. So, I have some questions for you:
    Should I continue to take the Optimal Fish Oil while on baby aspirin Lovenox? If so, how much?
    Do I need to take both the Sublingual Active B12 with Methyfolate AND L-5-MTHF? How much of each?
    If I took the Chewable Optimal Multivitamin, would the Sublingual Active B12 with Methyfolate cover my B Vitamin needs?
    I am taking D3 for a deficiency at 5000 I.U. (Country Life). Does this cover my D3 needs?
    I am taking Barlean’s Fish Oil EPA/DHA. How can I tell if it is in the triglyceride form?
    My current prenatal has been Nature’s Plus, Source of Life Prenatal Liquid, as I have thrown up every single other multivitamin I have ever tried. This one seems to be gentle on my stomach and cover a lot of the basic vitamins and minerals and being based in whole foods. I’m not sure if it’s because of the liquid form (I seem to tolerate liquid and chewable vitamins much better) or it’s whole food base (which I’m sure can’t hurt!) Have you ever taken a look at it? If not, are there any whole food prenatal multivitamins that you would recommend (preferably available in either chewable, liquid, or capsule form)?
    Thank you so much.

    • Dr Ben July 26, 2012 at 5:53 am # Reply

      Hi Katie –

      If you are taking the Barlean’s Fish Oil, then I would not add the Optimal Fish Oil. You may switch out the Barlean’s fish oil and then take the Optimal Fish Oil. You will have to ask your OB if you can take your fish oil along with Lovenox and baby aspirin. I would think your doctor would adjust your dose of Lovenox and baby aspirin so you could take your fish oil. It is important you take EPA/DHA while pregnant.

      You have to put a call into Barleans to see if their fish oil is triglyceride form.

      5,000 IU for vitamin D3 is pretty good. Measure your vitamin D3 levels to be sure your levels are good.

      Consider taking the Sublingual Active B12 with Metafolin first without the L-5-MTHF on its own. If your doctor wants you taking more methylfolate, then you will have to take L-5-MTHF in addition to the Sublingual Active B12 with Metafolin.

      If your prenatal contains folic acid and not any methylfolate, then I would veer away from it and use one that does. If your prenatal has both methylfolate and folinic acid, that is fine.

      I do not know of any liquid prenatal vitamins that are any good nor do I know of any that are chewable. The ones I recommend above are the ones I recommend via capsule or chewable.

      If you took the sublingual and the chewable multivitamin, that may cover your B vitamin needs – it depends on your labs, symptoms, history and what your doctor recommends you.

      • Deanna July 31, 2012 at 1:25 am # Reply

        Hello Dr. Ben,
        I was recently diagnosed with MTHFR, one of the C677T mutation and one of the A1298C. I found out at 10 weeks (which was too late) and then ended up finding out that the baby had severe NTD’s along with not completely developing. It was fatal but I did not miscarry, instead my doctor asked that I have a D&E. I have a perfectly smart and healthy 2 year old daughter and am completely confused on how this happened. We are currently trying to conceive again (two-three months after our loss) and my doctor has prescribed me Neevo DHA, 4mgs of folic acid, 50mcgs of B12, and 50mcgs of B6. I recommended the Neevo but I do not understand the folic acid. I also cannot find B12 and B6 that low in dosage. Is there anything I could supplement for the folic acid and B6 and B12? Also, since I didn’t actually miscarry, do you recommend that I take baby aspirin still? Thanks for your time.

  18. Angela Perez July 28, 2012 at 2:42 pm # Reply

    Hi Dr. Ben,

    I have some questions. I was recently pregnant and lost the pregnancy at 9 weeks. I found out 2 weeks prior that I had MTHFR one of the C677T mutation and one of the A1298C. I am 42 years old.I have one son who is 13 years old and that pregnancy was fine. I did not know about the MTHFR.
    We are wanting to TTC again soon.
    My Dr. has me taking this: NeevoDHA, 1MG of folic acid, 1 81mg asprin, and 1 D3 1000iu.
    My question is I want to switch the folic acid I am taking now to the correct kind. I am going to order the L-5-MTHF 1000 that you recommend here. I wanted to know how much you thought I should be taking in addtion to the NeevoDHA?
    Also, I was thinking about the Chewable Optimal Multivitamin but wanted to double check that it’s ok to take with the NeevoDHA? I had thought that the Neevo and all I needed but after looking at your site I am thinking it doesn’t.
    I am looking for a new OBGYN although I love mine, I need one that knows a bit more about MTHFR. Mine did tell me he would put me on Lovenox if I get pregnant.
    Any advise would be appreciated!!

  19. Lacy August 3, 2012 at 2:06 am # Reply

    I just found out i am heterozygous MTHFR 1298C after my 4th miscarriage. I also am heterozygous for factor 5 leiden. I have a healthy 5 yr old but after that pregnancy I have had 4 pregnancy losses. With the pregnancies I have done lovenox injections because of the factor 5 leiden. We are now trying to get pregnant again. I am taking 2mg of folic acid (OTC), is that what I should be taking or does it need to methylfolate?? I am also taking vit b6 and b12 to help with absorption. Any other meds my doctor should consider??

    • Dr Ben August 5, 2012 at 7:22 am # Reply

      Hi Lacy –

      There are many factors at play here and all need to be carefully evaluated for increasing the likelihood of a positive outcome and healthy child.

      I do recommend everything mentioned in the article here for those who are pregnant. I also recommend that the father/husband/partner supplement properly as well in order to provide healthy epigenetics to your developing child.

      I also think that baby aspirin in addition to Lovenox may be useful. You will have to talk with your hematologist and/or OB/GYN about this.

      • Lacy August 5, 2012 at 6:23 pm # Reply

        I did just order new prenatal vitamins with folinic acid and the metafolin to take instead of the OTC folic acid. I have been taking baby ASA when we are in the trying process and then switch over to the lovenox once I have a positive pg test. Do you think that by taking these meds that it would cover my bases or are there other ones you would recommend?

  20. Aleina August 5, 2012 at 2:14 am # Reply

    Is there a reccomendation for how much methylfolate to take when you have had a prior pregnancy with a NTD? My doctor had me on 4mg folic acid during my last pregnancy, which seemed to work (had a healthy baby), but I definitely want to stay away from that next time around and stick to methylfolate. But I’m nervous! I haven’t been able to take more than 1mg without side effects and I’m worried that won’t be enough. I know that it’s better absorbed than the folic acid, and my rational brain understands that less should be fine, but I definitely don’t want to deal with another NTD. Just curious if you have any thoughts!

    • Aleina August 5, 2012 at 2:15 am # Reply

      Oh and I am compound hetero if that makes a difference.

    • Dr Ben August 5, 2012 at 7:03 am # Reply

      Hi Aleina –

      4 mg is the standard recommendation during pregnancy for past miscarriages and past NTD; however, that is using standard folic acid – not methylfolate and folinic acid.

      I do not know – nor does anyone – how much methylfolate and folinic acid to use during pregnancy for those having past NTD.

      I believe if you could take 3 mg of folinic acid and 1 mg of methylfolate, that may be a good combination for you. The goal here for me is to limit the amount of unmetabolized folic acid circulating in your system.

      If you get side effects, then maybe you do not as much as you did prior.

      The prior pregnancy with NTD – were you recently taking birth control pills or not supplementing with adequate nutrients prior to pregnancy? Digestive disorders?

      You may also test many different types of folate forms by taking this methylation test – I think this along with the unmetabolized folic acid test would be very useful tool in combination.

      Your doctor will likely not know how to interpret either test - I am available via consults to help you should you decide to order them.

      These are all questions that must be evaluated.

      • Aleina August 5, 2012 at 3:47 pm # Reply

        Thank you for your reply.

        I just remembered that I did take some folinic acid during my last pregnancy, along with the folic acid. I didn’t realize folinic and methylfolate were different, that’s good to know.

        I had been on hormonal birth control (nuvaring) just before getting pregnant. Definitely wasn’t supplementing before pregnancy (wasn’t planning to get pregnant) and have had some digestive issues my whole life. Plus my diet was not the greatest then (a lot better now!).

        I’ll look into those tests, thank you!

      • Erin August 7, 2012 at 12:20 am # Reply

        Hi Dr Ben!

        So you recommend 3 mg of folinic acid and 1 mg of methylfolate? I thought the idea was to get more methylfolate if you don’t absorb folic acid. I am compound hetero as well trying to conceive after 3 miscarriages and I was trying to work up to like 3.4 mg of methylfolate as I thought that was the best form of active folate to take. I wasn’t even considering folinic acid. I feel like I haven’t even seen any info on that. Would you mind explaining more as I want to make sure Im taking the right vitamins.

        Thank you!

      • Aleina August 20, 2012 at 10:59 pm # Reply

        Hi again,

        Just wanted to update that since I started taking the methylfolate with methyl b12, I haven’t had any side effects. I’m up to 1mg in my prenatal, 1mg on it’s own, and 2 sublingual active b12′s a day and feeling great. Not sure if I’m pregnant yet, but feeling a lot more confident that if I am, I’m well supplemented. :)

        Thanks again!

  21. Stephanie August 18, 2012 at 6:40 pm # Reply

    Hi-
    I found out my 12 week baby had anencephaly and I had to terminate the pregnancy. I was diagnosed with homozygous c677t and negative for the other. My doctor tested my homocysteine levels – they came back at 5- and then
    put me on Folgard 2x a day
    After doing my own research I saw Folgaurd probably wasn’t going to be enough. I too scared to stop taking it altogether so now I take:
    1 Folgaurd, 5 mg Thorne 5-mthf, Neevo DHA, vit D, fish oil, and a liquid B complex. Anything you would add/take away? I can’t go through this again and am ready to ttc again but want to make sure my body is ready.
    Thanks so much for all you do here!

    • Lynn_M August 22, 2012 at 6:36 am # Reply

      Drop the folgard and maybe the liquid B complex. You don’t want to take anything that has folic acid and cyanocobalamin in it. They competitively inhibit the forms you need, L-5-MTHF and methylcobalamin. You can add B6 and methylcobalamin as separate supplements, or Dr. Ben sells a combo product. You might do better taking the active P5P form of B6.

      A homocysteine level of 5 seems low. Ideal is 6.3.

  22. Tania Diogo August 30, 2012 at 6:33 pm # Reply

    I try to eat a whole food real food diet and have not been taking a prenatal b/c I could not find one with ‘real’ (not synthetic) vitamins. I am 24 wks pg with #2. I do take Fermented Cod Liver Oil. I suspect we have MTHFR (lots of tongue ties etc in our family includig my 11 m old). What do you think of a prenatal such as
    http://www.iherb.com/Garden-of-Life-Vitamin-Code-RAW-Prenatal-180-UltraZorbe-Veggie-Caps/39196

    They ship to Canada, but I noticed that it has ‘folate’ is this the same as folic acid? I don’t want to take any form of folic acid aside from the ones recommended for MTHFR.

    • Lynn_M August 31, 2012 at 2:54 am # Reply

      I had your same concern regarding a different supplement. It was a whole-foods based non-synthetic liquid supplement which supposedly provided every nutrient needed by our bodies. The ingredient listed folate and I wasn’t sure if that meant MTHF or not. So I did some researching about the forms of folate found in vegetables and fruits.

      I think it’s very unlikely the folate in your product is folic acid. However, based on the prevalence of various folate forms in vegetables and fruits, the folate is probably one of the intermediary forms found inbetween folic acid and MTHF in the folate cycle. There might be some MTHF in there, but I wouldn’t count on there being much. You probably would be wise to additionally supplement with MTHF.

      • Tania August 31, 2012 at 4:47 pm # Reply

        Thanks Lynn. The reason I am concerned is b/c I read that people with MTHFR should NOT ingest any sort of synthetic folic acid as this can interfere with the bodies absorption of ‘real’ folate. I do plan on taking an additional supplement of MTHF, as well.

  23. Lena August 31, 2012 at 4:39 pm # Reply

    hi Dr. Ben,

    I am 6 weeks pregnant, naturally conceived, after 2 years of infertility. I found out at 5 weeks pregnant that I have homozygous A1298C mutation and have been taking b-vitamins, 5-MTFH and baby aspirin since finding out my diagnosis.

    I am terrified because I was not taking the proper supplements until 5 weeks into my pregnancy, my pre-natals only contain 600mg of folate. I am scared not only of miscarriage but even more so, down syndrome and NTD.

    I’d appreciate any insights.

  24. Jennifer September 3, 2012 at 6:17 pm # Reply

    Hi Dr. Ben,

    In my quest to find a good prenatal vitamin, I made an inquiry to Designs for Health, after seeing it listed on one of your posts. I asked specifically what type of methylfolate they used (they call their folate blend “NatureFolate”, which I thought I had read somewhere on here that it was not a good type). This is the response I received from them:

    “NatureFolate is a blend of the natural S-form of both 5-Methyl and 5-Formyl tetrahydofolate. The amounts of each is proprietary information. ”

    Would you consider this to be an acceptable form of methylfolate for a heterozygous C677T person like myself?

    Thank you for your advice,
    Jennifer

  25. Summer Bonnet September 12, 2012 at 12:18 pm # Reply

    Hi Dr Ben,

    I had a consult with you a about two months ago. I am MTHFR – C677T, heterozygous. I have had three miscarriages, I was told these should not have happened due to my mutation as my homocysteine level is within normal range – from memory 9. I am following your advice, my obstetrician and naturopath – I would like someone as educated as you on mthfr around the corner from me, but sadly there is not.

    As I have started to try an conceive I was hoping you could double check the supplements I am taking: (some are not your vit’s, I purchased them prior reading the info on your site, others are recommended by my naturopath)

    L-5-MTHF 1000 – SeekingHealth – 1 per day (at lunch with food) – should this be changed to two per day?
    Folinic Acid 384ug – Pureinnovation – 2 per day (one am & one pm with food) – should this be changed to one per day?
    Sublingual Active B12 – SeekingHealth – 1 per day (am with food)
    MultiBiocomplex Multi Vit – Nutri medicine – 1 per day (lunch with food)
    Permular Extract of Vitex agnus-castus – 1 per day (am one hr before food)
    Lavandula Compound – Nutri medicine – 2 per day (am with food)
    Active CoQH – SeekingHealth – 1 per day (Lunch with food)
    Omega3 40:20 – Nutri medicine – 2 per day (two am & two pm with food)
    Mag300 biocomplex – Nutri medicine – 1 teaspoon (mid morning after food)
    Optimal VitE – SeekingHealth – 1 per day (am with food)
    Redsuperkrill – goodhealth – 1 per day (lunch with food) wanted to purchase yours, has the extra astaxanthin but it could not be shipped internationally.

    I also take Niacin now and then – a quarter of a 100mg tablet – I am not sure how to use the niacin.. I know it soaks up too much methylation.. I am just not sure how much methylation I need. Is too much methylation bad for you in health terms? I don’t want the niacin to take away the good that I am putting in (I also make a green smoothy as part of breakfast, juice greens about every second day ect)

    You also mentioned some tests I should get done in the consult, (I thought the consult was getting taped), I did scribble these down, but I have lost my note book… sorry for the trouble.. but are you advise these again?
    Lets hope I am doing everything I can.

    Kind regards
    Summer (alias)

    • Lynn_M September 12, 2012 at 10:44 pm # Reply

      Summer,

      I would not take anything sublingual, such as the active B12, with food. Food inhibits absorption.

      • Summer Bonnet September 13, 2012 at 7:41 am # Reply

        Thanks Lynn, I will make that adjustment. So one hour before or after food would be ok?

        Are you also able to comment on the folinic acid and L-5-MTHF 1000, plus the other Q’s? I’m hoping I get a positive test in about three days time x

        • Lynn_M September 13, 2012 at 2:49 pm # Reply

          Yes, one hour before or after food is okay on Vit B12. The other thing to consider is you don’t want to take Vit B12 within 45 minutes of taking Vitamin C, otherwise the Vit C inactivates the B12..

          Regarding how much folinic acid and L-5MTHF to take. Dosing is so individual, it’s hard to say. When you want to change dosing of something, I would change one substance at a time and give it at least a few days to see if you feel any impact. Personally, I would take more L-5MTHF than folinic acid.

          I muscle test everything I take, and my body doesn’t necessarily want the same substances in the same doses every day.I found some chiropractic research that supposedly affirmed the validity of muscle testing, but I could only access the abstracts. I do the sway test when testing myself, and I also have a health practitioner that double-blind tests supplements and foods for me using a different technique. I don’t know if doctors other than chiropractors think muscle testing has any value.

          As it gets metabolized, niacin eats up the methyl groups that you’re trying to increase. I wouldn’t take it unless you have symptoms of overmethylation (irritation & anxiety). You’re probably getting your sufficient RDA of niacin in your green smoothies and juices.

          And remember that treating MTHFR is far more than just taking supplements. Avoiding toxicity, both from external agents and from what we generate internally when we’re in fear and anxiety, relieves the body of the need to detox, and spares the B vitamins for body-building rather than detoxing.

          • Summer Bonnet September 17, 2012 at 10:11 am #

            Hi Lynn,

            Thank you for your reply. Working out what my body needs is the problem, finding a health professional close to me who is an expert in this field is also a problem.

            I have always experienced, I think mild, symptoms of anxiety (maybe they are not so mild for the average person). So I am finding it difficult to work out how much L-5MTHF and folinic acid to take – I am not sure if it’s the vits making me anxious and irritable – or if I’m just trying to deal with too much and pushing on. I think instead of taking two L-5MTHF and one folinic acid (which I was thinking of changing too above), I will take one L-5mthf in the morning and one folinic acid at night, plus eat or drink lots of leafy greens. As I am wanting to have a child, and due to the MTHFR – C677T, plus three miscarriages, I feel the risk of overmethylation is better than undermethylation… ? .. I hope.

            Anyway, thank you for providing this information (there are still health professionals out there who are prescribing just folic acid – or disregarding completely), between work and study I will educate myself more, plus start relaxation techniques. I will be due to order some vitamins soon.

            Kind regards
            Tanya

  26. Andrea September 17, 2012 at 2:46 pm # Reply

    Hi Dr beneficios I amor heterozygous for the C677T if I had todo choose one suplement for now which one do you recommend? I think it will be the optimal multivatamin what do you think.

    • Dr Ben September 17, 2012 at 8:34 pm # Reply

      Hi Andrea –

      Without a history, that is tough for me to state; however, if you are looking for general support and are not sensitive to supplements, yes, Optimal Multivitamin would be a good start.

      • Andrea September 23, 2012 at 12:50 am # Reply

        Hi Dr.Ben this is my history,in 2001 I lost a baby at 12 weeks Dr told me it was normal,in 2003 my son was born without complications it was a natural delivery,last year after 8 years of having mi first born I decided to get pregnant again didn’t have any problems with that but at week 13 started spotting and by week 18 started heavy bleeding plus blood clots Doctors told me I had placental abruption,I also had a urinary infection that never went away,two days before week 23 I lost almost all amniotic fluid and at week 23 baby was stillborn:( the pathology of the placenta came out normal,so confuse about that.Anyway months later went for testing and this is what I have. MTHFR one copy of the C677T. I am 29 years old. THANKS

        • Andrea September 23, 2012 at 12:55 am # Reply

          Forgot to say I really would like to try to conceive soon,right now I am taking B rigth complex and folate as L methylfolate as metafolin 800 mcg.thanks an so sorry really trying hard with mi English.

          • Andrea September 23, 2012 at 6:06 pm #

            Also I am thinking on taking the Thorne basic prenatal but have questions about the vitamin k in it,because I am taking aspirin and plan to do the heparin during pregnancy.

  27. Amy R September 22, 2012 at 5:05 am # Reply

    Dr Ben,
    I have been taking your optimal multivitamin capsules for a couple of months now. I recently found out I am expecting. I am compound heterozygous for MTHFR and will try to follow the above guidelines. One question though, I don’t see the optimal Multivitamin capsules listed as one of the multivitamin options above. Is there a reason for me to switch to a different multi while pregnant? Also, I saw another post asking about licorice in the chewable multivitamin from seeking health being contra indicated for pregnancy but didn’t see your reply. Is that something to be concerned about with the chewable?
    Thanks so much for your knowledge and help!
    Amy

    • Dr Ben September 24, 2012 at 9:14 pm # Reply

      Hi Amy –

      Congratulations :)

      I would like to see you take something like Xymogen’s Prenatal or Thorne’s Prenatal.

      The licorice is not a good idea to take while pregnant. The tiny amount found in the chewable is likely fine but due to the sensitive nature of pregnancy, I would like you and others to avoid it.

      • Andrea September 27, 2012 at 6:23 pm # Reply

        Hi Dr.Ben this is my history,in 2001 I lost a baby at 12 weeks Dr told me it was normal,in 2003 my son was born without complications it was a natural delivery,last year after 8 years of having mi first born I decided to get pregnant again didn’t have any problems with that but at week 13 started spotting and by week 18 started heavy bleeding plus blood clots Doctors told me I had placental abruption,I also had a urinary infection that never went away,two days before week 23 I lost almost all amniotic fluid and at week 23 baby was stillborn:( the pathology of the placenta came out normal,so confuse about that.Anyway months later went for testing and this is what I have. MTHFR one copy of the C677T. I am 29 years old. THANKS

        Andrea September 23, 2012 at 12:55 am # Reply
        Forgot to say I really would like to try to conceive soon,right now I am taking B rigth complex and folate as L methylfolate as metafolin 800 mcg.thanks an so sorry really trying hard with mi English.

        Andrea September 23, 2012 at 6:06 pm #
        Also I am thinking on taking the Thorne basic prenatal but have questions about the vitamin k in it,because I am taking aspirin and plan to do the heparin during pregnancy.

      • Amy R February 8, 2013 at 1:12 am # Reply

        Dr Ben,
        I lost the baby I mentioned above and then another one a few wks ago. So two miscarriages this time so far (I had three before my now 3 year old was born).
        I was on heparin, low dose aspirin, Thorne prenatal, MTHFR supplements (L5 MTHF and the B12 lozenge) for both of my recent miscarriages. My question is this, when I get 1 mg folate from Thorne, 1 mg from L5 MTHF and 800 mcg from Active B12 I am unable to sleep at night. If I cut out the active b12 lozenge I sleep fine. I’m worried though with cutting it out and only taking 2 mg of folate given my miscarriage history, my compound heterozygous MTHFR for both C and A and my factor V Leiden. Am I getting enough folate since over 2 mg seems to give me adverse side effects? Especially concerned after now having two more miscarriages even with treatment. With my successful pregnancy I was actually on Folgard.
        My MD is telling me we will start prednisone with the next pregnancy to see if that helps. I saw on the MTHFR protocol in pregnancy on this site that the MD that responded to the women’s questions had a steroid listed. Is a steroid ok to take?Any additional supplements I should take if I’m on a steroid with the next pregnancy?
        Thank you so much!
        Amy

  28. Melissa October 1, 2012 at 6:56 am # Reply

    This is very helpful. I’m so thankful I found this website. Thank you! My question is if I take the Thorne Prenatal, do I really need ALL the other supplementations listed? The Thorne Prenatal has 1mg of folate already. I am heterozygos for the C677T mutation and I don’t want to take too much methylfolate. Is the 1 mg in the Thorne prenatal enough for me or do I also need the Sublingual Active B12 with Methylfolate, and the L-5-MTHFR supplements you recommend as well?
    My history- My first pregnancy in 2009 resulted in severe IUGR and preterm labor at 35 weeks (she was only 3 lbs, 11 oz). She is otherwise fine, but still very small for her age. For my second pregnancy I was treated with Lovenox, baby aspirin, and Folgard due to my pregnancy history. At that time I didn’t have any blood tests done but my IVF doctor treated me with his “implantation failure” protocol (Lovenox, BA, Folgard) due to the IUGR in my first pregnancy. Unfortunately, I lost the baby at 18 weeks. I was shocked that I miscarried because I thought the Lovenox and BA would help, not make the outcome worse! After reading your website, I think maybe the key is to not take the Folgard and supplement with what you suggest. After my miscarriage, I had a million blood tests done and the only thing that came back positive for me was the one copy of the C677T mutation. Everything else was completely normal. I was told that the one copy “means nothing to my healh” especially since my homocystine levels were normal. Thanks to your website, I am learning that is not true. My husband and I deperately want to have another baby and we are getting ready to try another round of IVF. However, I am scared to death since I already “failed” being on the Lovenox, BA, Folgard protocol. Any help or suggestions would be greatly appreciated! Thanks for your time.

    • Melissa October 2, 2012 at 5:29 am # Reply

      Are all the supplements you list here safe to take while going through an IVF cycle? In other words will any of the supplements interfere negatively with the IVF drugs (i.e. estrogen, progesterone) that one needs to be on when getting the body ready for implantation?

  29. Erin October 11, 2012 at 4:23 pm # Reply

    Hi Dr. Ben, Thank you so much for all of this information on MTHFR and prenatal supplements. It has been extremely helpful! I have PCOS and have had amenorrhea for several years. I used Clomid in 2010 in order to get pregnant with my first baby. Now, trying to have my second baby, I went dairy- and gluten-free earlier this year in hopes of bringing my cycle back. I also returned to the fertility center and it is standard practice for them now to do genetic testing. I recently found out that I am compound heterozygous MTHFR. I am trying to determine how much methylfolate, folinic acid, and methylcobalamin I should take daily before and during pregnancy. My midwife is not knowledgeable about MTHFR and does not have a recommended dosage for me. I am planning to take many of the supplements you recommend, including Thorne Basic Prenatal and Seeking Health Active B12 with Methylfolate Lozenge (2 per day). If I do that, I will have 2100 mcg of methylfolate, 500 mcg of folinic acid, and 2000 mcg of methylcobalamin per day. Is that an appropriate amount during pregnancy? I don’t want to take too much nor too little. Thank you so much!

  30. Jennifer October 28, 2012 at 10:53 pm # Reply

    Hi Dr. Ben,

    In my research for a good prenatal vitamin for someone with a single copy of C677T mutation, I have come across the Mega Food brand, and was wondering if you might have any feedback. It is a whole-food supplement. It appears that the folate is derived from broccoli, and many of the other B vitamins from s. cerivisiae (brewers yeast, as I understand it). Here is a link to their prenatal vitamin page:

    http://www.megafood.com/womens-health/baby-and-me

    What is your opinion of the type/quality of folate and B vitamins derived from these food sources?

    Thanks so much for your advice,
    Jennifer

  31. Amy R November 1, 2012 at 3:12 am # Reply

    Dr. Ben,
    Any reason not to use Homocystex from seeking health while pregnant? Can you also help me understand the difference between Homocystex, sublingual active B12 and L-5 mthf?

    • Dr Ben November 5, 2012 at 7:29 pm # Reply

      Amy –

      You have to ask your doctor(s).

      To me, HomocysteX is fine to use while pregnant.

      The differences between the three products you mentioned are the ingredients contained.

      HomocysteX: contains 1000 mcg methylcobalamin, 800 mcg methylfolate and 25 mg pyridoxal-5-phosphate (B6)
      Sublingual Active B12 and L-5-MTHF: contains 1000 mcg methylcobalamin and 800 mcg methylfolate

      Some individuals do not do well with added B6 which is why I have this nutrient excluded in some of the other formulas. Some also do not need additional B6.

  32. Autumn November 1, 2012 at 3:41 pm # Reply

    Hi Dr. Ben,

    Three questions:

    1. I am taking Thorne’s Methyl Guard Plus. There’s multiple things in that. Do you like MGP, and if so, when I’m taking that, which of your recommended supplements do I NOT need?

    2. Like another mom asked, is there any reason you wouldn’t recommend MegaFood Baby & Me prenatal, a food-based prenatal. I know the folate in it is not all we need, but are there reasons it wouldn’t be good as a prenatal?

    3. Would any of your recommended supplements be contraindicated if a person tends toward excessive bleeding?

    Thanks for your podcast.

    Autumn

    • Autumn November 1, 2012 at 3:43 pm # Reply

      Forgot to say – homozygous C677T.

  33. Victoria P November 25, 2012 at 9:11 pm # Reply

    Dear Dr. Ben, I was diagnosed with 2 mutations several years ago after 2 recurrent miscarriages. One A1298c and one C677t. At that time, I was put on a regimen of Metanx, baby aspirin, Lovenox and progesterone. It seemed to do the trick because I now have a beautiful almost 4 year old son. We are trying to get pregnant again, but I am 38 yo, and seem to be having A LOT more trouble just getting the two blue lines. My current regimen is Neevo DHA, baby aspirin, progesterone. Lovenox after confirmed pregnancy. My questions are;

    1. Does age affect mthfr and change of supplementations for successful implantation/pregnancy?

    2. I just ordered some Fertile CM supplements from Early-Pregnancy-Tests.com to help with my dereased cervical mucous. It contains Calcium(from Coral Calcium), L-Arginine, N Acetyl Cysteine, Grape Seed Extract, Lactolbacillus Acidophilus. Will this interfere in any negative way?

    Thank you very much!

  34. Katie November 28, 2012 at 4:11 pm # Reply

    I am currently 12 weeks pregnant after 1 healthy son and then two losses, one at 20 weeks and one at 7 weeks. After my losses, I was diagnosed as compound heterozygous MTHFR. I have been taking the Seeking Health sublingual B-12 with Methylfolate along with my prenatal, Vitamin Code RAW Prenatal. The prenatal is made from all whole, real food sources, and it says it has “Folate – 800mcg”. My OB took a look and thinks the prenatal is sufficient for my folate needs. My question is: What is the difference between Folate and Methylfolate? What difference does that make for a person with the MTHFR mutation?

  35. Eliza December 3, 2012 at 6:53 pm # Reply

    Hi Dr. Ben,

    I don’t want to make this too long so i’ll try to shorten as much as possible. I am currently 18 weeks pregnant, I was diagnosed by an RE in August the month we conceived with MTHFR A1298C. We saw our RE after we had our third Miscarriage. I am now seeing a perinatologist along with my OB and the perinatologist has asked that I take 500mg of b6 2x’s a day and 500 mcg of b12 once a day along with 81 mg of aspirin. The prenatal I take is OB complete which includes 1mg of folate. I feel like I’m taking too much b vitamin and I expressed that to the doctor but upon asking why so much he simply said that I don’t process b vitamins well and that was the proper dose to take. I am confused, is this too much??

  36. Tina December 16, 2012 at 7:15 pm # Reply

    Dear Dr Ben, how much vitamin B6 do you recommend with your above recommended “prenatal supplementation” protocol?

  37. Kris Mason December 26, 2012 at 3:00 am # Reply

    Hi Dr. Ben

    After our consultation in October, I’ve been taking the recommended prenatal, the Active B12 Lozenge with L-5-MTHF and the Active CoQH. I have tolerated them very well and my symptoms of tingling and numbness in the feet and hands have gone away. Thank you so much for the recommendations.

    I have two copies of the C677T, and have miscarried twice. I’ve also had one failed IVF procedure. In the past my doctors recommended lovenox, baby aspirin and high doses of folic acid. Since speaking with you, I now know better about the folic acid,and have decided on the new regiment listed above. In one month ,I will begin my second attempt at IVF and am wondering if I should switch to the Homocystex Plus in place of the lozenge?My vitamin D3 is low, and I am taking the Prenatal Essentials vitamins. Is the vitamin D in that prenatal sufficient, or should I also start on the D360?

    My goal is to have a healthly baby. We’ve been trying for 5 years, with one obstacle after another. I feel like once I received all of that valuable information from you and the website, that at least we have a chance now. Thank you for everything!!!

    Looking forward to hearing from you.
    Thanks
    Kris

    • Dr Ben December 26, 2012 at 3:29 am # Reply

      Hi Kris –

      Great to hear you are doing better ;)

      I would recommend the HomocysteX Plus. That is a good idea. I suggest you consider this as well because it has additional riboflavin and methylation support which may be useful right now. Start low and work up. Do use it instead of the lozenge for now. Again, see how you feel and adjust how many you are taking with your symptoms. Work with your doctor on this.

      There is no multivitamin that I have seen that has enough vitamin D3 in it. I do recommend the liquid vitamin D – and at least 3 drops a day – which provides 6,000 IU. You may take it anytime. If your vitamin D3 level is quite low, your doctor may have you take 10,000 IU a day or more. Do follow their recommendations and be sure to retest in a few months.

      Be sure to continue supporting yourself thoroughly all the way through pregnancy and breastfeeding.

      Do consider the Optimal Liposomal Vitamin C as well as it has additional choline in it as phosphatidylcholine – plus liposomal vitamin C. Consider taking 1 to 2 tsp daily.

      Do look into taking a fish oil or at least measuring your red blood cell fatty acid content. It is important for these to be balanced.

      Keep me posted how you are doing!

      • Kris Mason December 26, 2012 at 8:30 pm # Reply

        Thanks Dr. Ben. I appreciate your quick response. I will definitely keep you posted.

  38. Summer Bonnet December 26, 2012 at 4:23 am # Reply

    Hi Dr Ben,

    I have two questions, other than mood temperament (which I was affected with at first, but do not seem to be now) is there any other adverse effects of taking too much methylfolate? and is taking all the supplements in your podcast and including your optimal multivitamin (instead of a prenatal multi) good enough?

    I am taking all of the above Supplements mentioned in podcast. Dosage of the L-5-MTHF is one in the morning and one at night as well as one folinic acid (perscribed by my naturopath) at lunch.

    I do not take a prenatal Multivitamin as I can not get hold of Thorne Basic Prenatal or Xymogen Prenatal Essentials in Australia. I alternate between your Optimal Multivitamin (around 5 a day) and Mulit Diocomplex (which my naturopath recommended – it includes in its list folic acid and cyanocobalamin – so unsure on it).

    Thanks Summer

    • Summer Bonnet December 26, 2012 at 4:24 am # Reply

      Also do you recommend B6?

  39. Meg January 6, 2013 at 3:14 am # Reply

    Thanks for all your help, I have been reading through your site all night.

    I have MTHFR, Factor 5, and a possible thyroid issue. I lost our first baby at 9 months pregnant, since then I have had 3 healthy full-term pregnancies. We also hope to have more children in the future as well.

    I am a bit confused. My Dr. and my specialist told me last year that the new research said Lovenox does not make a difference during pregnancy (for MTHFR patients). They did put me on folic acid and baby aspirin.

    Now after reading this, I know the folic acid should be avoided, and I am starting to think I SHOULD be taking Lovenox during pregnancy.

    Anyway, Right now I take the following:

    1. New Chapter Prenatal (no GMO’s which is important to me)
    2. Probiotic
    3. Fish Oil
    4. D3
    5. Carlson Tri B (B6 + folate + B12)

    We also eat very healthy and juice daily. Can you let me know if this looks OK? I am a bit confused as to which Methylfolate is right in the seeking health online store.

    Thanks so much!

  40. Kris Mason January 14, 2013 at 6:12 pm # Reply

    Hi Dr. Ben,

    I have been taking the Xymogen Prenatal Essentials and I tolerate it fine but they are a bit costly. I noticed that you have added another recommendation, Thorne Basic Prenatal which is considerably less expensive. Can you tell me if one is better than the other as far as quality and what benefits they provide?

    If Thorne is just as good as Xymogen, I could save a few dollars and use Thorne. But if Xymogen is better, I’m fine with paying the price for it. I would like to get your input on this matter.

    Thanks

    • Andrea January 16, 2013 at 4:19 pm # Reply

      hi Dr Ben!! I just took the Active b12 Lozenge and started shaking,is that normal because it is the first time????

      • Dr Ben January 16, 2013 at 9:24 pm # Reply

        Andrea –

        I highly recommend that people start very slowly on methylation supportive nutrients as they can be potent.

        I also am now recommending that people take methylation supportive nutrients within 20 minutes of eating. This is because methylation supports neurotransmission and if your blood sugar is imbalanced, then it may cause shaking or irritability.

        Do let your doctor know how you responded to the B12 and how much you took – and if you took it around a meal or not.

        To counteract the many potential side effects of methylation support, niacin may prove useful.

        • Andrea January 20, 2013 at 1:59 am # Reply

          HI DR BEN THANK YOU FOR YOUR ANSWER I WAS ACTUALLY TAKEN THE SAME DOZE OF THE LOZENGE BUT ANOTHER BRAND AN NOTHING HAPPENED,I GUESS WHAT HAPPENED WAS THAT I TOOK IT IN THE MORNNIG WITHOUT FOOD,I AM NOW TAKING IT 30 MINUTES TO ONE HOUR AFTER A MEAL AND IT WORKED,I’M ALSO TAKING THE L-5 MTHF AND THORNE PRENATAL AND I FEEL GOOD,IS THERE ANY SIGN THAT SAYS THAT IT IS TO MUCH.

    • Dr Ben January 16, 2013 at 10:03 pm # Reply

      Kris –

      I prefer Xymogen’s hands down.

      • melissa January 20, 2013 at 6:45 pm # Reply

        Hello Dr Ben,

        I have a question for you, I have had 7 now 8 pregnancy no miscarriages. My 7th pregnancy our daughter was stillborn at 41 weeks from a placental abruption. I have had no other problems with my other pregnancy’s. After our daughter was born I asked to be tested for all clotting disorders including MTHFR. The only one that came back positive was the MTHFR and I have one copy of the C677T gene. I am currently 19 weeks pregnant. I am currently taking

        Thorne Prentals 1 capsual should I be taking all 3?
        Metax 1mg

        Should I be taking fish oil and COQ10?

        My OB has not suggested asprin or blood thinners, due to no other clotting disorders or recurrent misscarriages. Should I be taking taking asprin or blood thinners to prevent another abruption? Also so far my ultrasounds are showing all is good with this pregnancy and placenta. Thanks

      • kirsty December 4, 2013 at 4:37 am # Reply

        Dear Dr Ben,
        Have one copy of MtHFR, think ends in 167. Need to retest other copy as wasnt tested here in Australia. I am high positive for Anticardiolipin IgG and factor v lieden. I had lupus Nephritis at age 12 but in remission past 15 yrs but have secondary Antiphosholipid syndrome. My father gave me fvl. I suspect mother MtHFR as she is hypothyroid and had a dvt when 7 mths pregnant
        With myself and has thickened blood. I’ve had sluggish thyroid andafter miscarriages i went onto replacement both t 3 and t4. I’ve improved. Unaware I couldn’t methlylate. and knowing that maybe I’m loosing to this.
        I be battled infertility and poor implantation on ivfcycles.Ihave recently known of my MtHFR and started folinic acid daily. My ferritin low so had iron infused and is good. I had borderline.low vit d and its come back up after 10000 iu. Now on 4000.
        I need know if I need all the supplements recommended by you and how do I get how do I buy in Australia. Look forward hear from you.
        .

  41. Summer Bonnet January 28, 2013 at 6:45 am # Reply

    Hi Dr Lynch,

    I live in Australia, the freight from the US is costly. Are you able to sell your products through iHerb? Thanks Summer

  42. Christy January 30, 2013 at 2:01 am # Reply

    Hi Dr. Ben,

    I am homozygous c677t and am following your protocol for general health with the intent to try to get pregnant in the next few months. I just ordered Homocystex and was wondering if I can take this during pregnancy in addition to the Thorne prenatal or if you recommend dropping back to the sublingual b12/methylfolate?

    Thank you!

  43. Jennifer February 8, 2013 at 3:12 pm # Reply

    Hi Dr. Ben,

    I just ordered the Xymogen Prenatal Essentials, and I see they come in a pack of 4 capsules plus 1 DHA capsule, but with no instructions for taking them, except to “follow the directions of your doctor”. I even tried calling the company, and they were not able to give me any better idea on when to take the various capsules. Common sense, plus what I have read on this forum, is telling me they are not to be taken all at once, but rather spaced out, but I’m wondering if you can give your advice on the best times to take them – i.e. how far apart – with or without food, etc.? Thanks so much for your input.

    • Elizabeth February 15, 2013 at 8:44 pm # Reply

      Dr. Ben,

      Thank you so much for all of your research and information regarding MTHFR. My husband and I have lost 6 children to miscarriage in the past 2 years and are currently 5 weeks pregnant. I just discovered your website ( wish I had sooner). I have compound heterozygous MTHFR. My doctor has me taking a compounded capsule filled with folic acid, B6 and B12. and I’m taking Lovenox 40mg daily and a baby aspirin. My doctor has me taking an over the counter prenatal along with 500mcg of extra folic acid. To make a total of at least 1,300mcg of folic acid not including what he puts in the compounded capsule he prescribed me. After reading your website and listening to your podcasts I feel that I am taking all the wrong things. I want to save this little one we are pregnant with!

      Does your list of supplements during pregnancy take the place of a prenatal or is it in addition to a prenatal? Also, can the Optimal Multivitamin Chewable take the place of my prenatal? or would I need more supplementation?

      Thank you so much!

      • Nadia May 23, 2013 at 5:13 am # Reply

        Just wanted to reiterate this question, as I have it too after listening to your podcast, and noticed others asking the same question in various forms:

        Does your list of supplements during pregnancy (1-10) take the place of a prenatal entirely, OR is it to be taken in the full amounts stated in addition to a recommended prenatal on your list, OR are we to supplement a recommended prenatal with the listed items (1-10) to reach the total stated amounts?

        I assume your list is in additional to a prenatal of some kind, as you mention in the podcast, the importance of sufficient iron, and the benefit if chia seeds and chlorella? But it’s not clear what the relationship is between items 1-10, and the recommended prenatals you’ve listed.

        Thanks!

  44. Summer Bonnet February 19, 2013 at 9:11 am # Reply

    Hi Dr Ben,
    I am c667t hetero, multi miscarriages, I am taking the L5 metafolin, b12 methycobalamin and the rest of the recommended list of prenatal essentials – I rattle when I walk and happy to do so for my body to function properly!!! I have just found out I have Pyroluria and I am wondering how many other people with the MTHFR mutation also have Pyroluria? Is there any magic suppliment that you feel is vital when someone has both Mthfr and Pyroluria?
    Thanks a bunch – your recommended list of suppliments have already helped me with anxiety, hopefully they can help me have a healthy baby – or if the risks are too high at least you have enable me to have understanding and allowed a healthier future. Again, thank you for your passion and will for a better future – for everyone.

  45. Danielle Netherton February 26, 2013 at 9:31 pm # Reply

    I notice that in the thorne prenatal you recommend it contains vitamin C in the form of absorbic acid. Why are you not recommending a whole foods based vitamin?

  46. Danielle Netherton February 26, 2013 at 9:39 pm # Reply

    Also,
    is it ok to take these supplements if you *dont* have the mutation?

  47. Jennifer March 5, 2013 at 4:09 am # Reply

    I was recently diagnosed with Homozygous MTHFR and am 16 weeks pregnant. I’m on lovenox, baby asprin, Folgard and a prenatal + DHA. Is it too late to make the change to the supplements you’ve suggested? I’m concerned about the links between MTHFR, folic acid and Autism. Thank you!

  48. Adrienne March 19, 2013 at 6:40 pm # Reply

    I am so glad to have found this site. My 2 year old son has chronic feeding issues and a major lip tie and suspected tongue tie as well that we just discovered. I too had a lip tie that tore and have slight tongue tie, which I thought was normal until now. After learning the link between that and MTHFR mutation, I want to make sure that I do everything right for my next baby. We only have temporary insurance right now, but we plan to get tested as soon as we can. In the mean time, I want to start taking a safe pre-natal vitamin now because we plan to have another baby soon after we get insurance through an employer. I am thinking of getting the Thorne Basic Prenatal…would there be any harm in taking this if I for some reason do not have the MTHFR mutation? Do I need to take a DHA capsule in addition to this? Also, is there a chewable or gummy children’s multi-vitamin you would recommend for a 2 year old with suspected MTHFR mutation that already drinks 1 pediasure/Kids Boost a day? Thanks so much!

  49. Eve April 12, 2013 at 9:34 pm # Reply

    Hi,

    Sorry – Just wanting to clarify. We are to do the whole list (going slowly) in ADDITION to the prenatal? Just wondering if the sublingual b12 would be too much in addition to what is in the Thorne (which I am taking). The combo of the sublingual and Thorne are ok then as far as b12 and MTHF when pregnant and breastfeeding (I am still breastfeeding my 24 month old)? Thanks.

    I am considering the xymogen bc the Thorn seems to have so much iron, although it does not constipate me. I just don’t like the mag. stearate in the xymogen. Is Dr. Ron’s “Docs best multi” and desiccated liver an ok alternative?

    Thanks for all that you do, wondering if your book is out soon?

    Eve

  50. Eve April 15, 2013 at 5:12 am # Reply

    Also wondering if Cod Liver Oil is a good option for fish oil, specifically fermented cod liver oil (for example when on GAPS).

  51. suzy May 15, 2013 at 12:58 pm # Reply

    Hi, I am taking the Prenatal Essentials from Xymogen that you have listed here as a recommendation, do they contain the correct for of folate?
    I see my label says “Folate- (400 mcg as (6s) -5-methyltetrahydrofolic acid, glucosamine salt and 400 mcg as calcium folinate”

    Which ends in “acid” not “folate”.

    I just want to be sure I am taking the correct form. Also what should I add to my prenatals from the above list? Do I need more folate/B12? I am not sure what else to order.
    Thank you

  52. suzy May 15, 2013 at 8:23 pm # Reply

    Hi Dr. Ben
    The Xymogen Prenatal Essential vitamins say “Folate- (400 mcg as (6s) -5-methyltetrahydrofolic acid, glucosamine salt and 400 mcg as calcium folinate” is this an ok form of folate?
    Also, should I add the L-5-mthf and b12 sublingual listed in the above list for my prenatal plan?

  53. Nadia May 23, 2013 at 6:07 am # Reply

    In your supplement list item #2, did you mean to write “1 mg of methylcobalamin?”

  54. Sheri May 25, 2013 at 6:52 am # Reply

    I am 34 years old and was recently diagnosed with having compound heterozygous mutations after requesting the test be done by my obgyn (4 miscarriages later). Previously I asked my primary care physician to test for the mthfr mutations, d3, b6, b12, folate, copper and zinc, etc., and again asked the hemotologist that my primary physician referred me to to test for the mthfr. The hemotologist looked over the blood clotting tests that were done by my primary and said that since my homocysteine levels were normal, antibodies were good, and I didn’t have leiden factor v that I didn’t need to test for mthfr. He said that they don’t really test for it very often and don’t really see a need. Luckily my obgyn agreed to test for it but at the same time I am discouraged that she prescribed the standard protocol of 4 mg. of folic acid/daily. She did not think that I needed a b12 vitamin and did not seem knowledgeable about the methylcobalamin form.

    My history: I have had 2 uneventful live births that I took for granted, 2 miscarriage (one at 6 weeks and one at about 9 weeks), 1 live birth, 2 miscarriages (one at 8 weeks, baby was 2 weeks behind, but did get to see heart beat at 2nd ultrasound and then started to miscarry that night-I took progesterone and the other miscarriage was at 4 weeks- I wasn’t on progesterone), and am now 6 weeks 4 days pregnant, back on progesterone. I am not considered to be high risk; they said that miscarriages are normal. I was told to go get pregnant and come back and see my former obgyn and the hemotologist said to get pregnant and come back to tell him all about it. Very frustrating to hear that when I know something is not right. This pregnancy I have been trying to take it easy but it’s hard not to worry. At my 6 week 2 day ultrasound they found subchorionic bleeding 3.5 cm and told me this is normal and not to worry. I am concerned because I do not know if I am producing clots even though the tests show differently. I have talked to the doctors for 8 years about my periods being clotty, since after my second child (live birth). I have now been to the same hemotologist twice to go over the blood clotting testing panel. I have been told that its all normal.

    Currently I am taking 125 mcg levothyroxine (hypothyroidism since 17 years of age) pharmaceutical grade fish oil 2 x daily, natural progesterone transvaginally after inquiring with obgyn a year ago, vitamin code whole food prenatals, wobenzym, vitamin k2, and d3 standard doses. Previously I was taking the active form of b6, metafolin 1600 mcg every few days and 800 mcg on the other days, 8,000 d3, pharmaceutical grade fish oil 2x daily, and vitamin code womens whole food vitamins. I just started researching mthfr and was confused as to what to do. The tests that I mentioned above done by my primary came back with my vitamin d3, b6, and folate being too high. Not surprisingly the folate was at 45, very bad on my part. I am also concerned that maybe my blood is too thin and is causing the subchorionic bleed. I’ve seen wobenzym n on other websites but not on your protocol for mthfr. I questioned my obgyn today as to why she wanted to put me on the high dose of folic acid when my previous tests showed that my folate was high and was told to stop taking any additional folic acid or folate. She said the bloodwork doesn’t actually show the amount of folic acid in my blood. I asked her about the possibility of a methyl trap and she said no, all is well and she’d feel more comfortable with me taking the folic acid, instead of the l-methylfolate because theres lots of research that shows the folic acid helps those with mthfr. However I found it interesting that she mentioned Deplin as an alternative option but said it was very expensive. I do not understand why she does not think that metafolin would work at a comparable dose to the 4 mg of folic acid she prescribed. Is there anything that I can do to help this pregnancy be successful? I am still learning. There is so much information to do through. Also do you know of any knowledgeable doctors in the Salem Oregon area for mthfr mutations? I would like to get the full panel tested. I am concerned that I possibly have the cbs mutation, etc, because I read that it can make the homocysteine levels normal. Thank you so much for the time and effort that you have put into helping people find truth. God Bless!

  55. Sheri May 26, 2013 at 8:15 pm # Reply

    I should have also included the lifestyle changes that me and my family have made since that is a very important piece to achieving healing. We switched to organic in our household over the last 6 months (starting after my miscarriage on November 5, 2012). I also take a probiotic with 50 million live activce cultures that has several strains. I also started taking epson salt baths a couple of months ago and using body brushing and massages. I took evening primrose to conceive on my most recent very early miscarriage, and currrent pregnancy, stopping after ovulation. Yesterday I picked up some sublingal active b12 (they only had it solo or with folic acid, so I opted for solo) and CoQ10, enhanced absorbption softgels (I meant to get the ubiquinol :( ), and natto-k. I already have metafolin and p5p. I wasn’t planning on taking more p5p, since it seems there is enough in my prenatal vitamin code vitamins? I wanted to follow the protocol I saw in one of your posts for individuals who have experienced multiple miscarriages. Taking 2 sublingal b12 upon rising and 2 before lunch and then to add up the methylfolate to equal 4 mg. I feel comfortable taking the natto k instead of aspirin with what I have read but am concerned with having my blood too thin because of the 400 iu vitamin e I’m taking to help with my subchorionic bleed (sac separated from wall slightly) to heal, the pharmaceutical grade fish oil I am on, and the wobenzym n I am taking. I have considered stopping the wobenzym n but am worried because many in my family have inflammation and I have always kept a low grade fever with all of my pregnancies that seems higher than a normal pregnancy temperature and have experienced joint pain throughout my life that definately improves when I stay active. I also read on one of your articles that inflammation effects the way natto k may work. I cut back on the wobenzym n to 3 tabs once a day instead of twice and started taking 50 mg of natto k last night. I am also now taking 1 mg of sublingal b12 twice a day and 1600 methylfolate, to work up slowly to the higher amounts. I am writing my life story. I have not been able to find support and accurate information anywhere else. Am I on the right track? I saw that a women used 100 mg a.m. and p.m. instead of aspirin and/or lovenox and it worked for her. I wonder if that will work with all that I am taking. One final question. I have seen mixed reviews on epson salt baths during the first trimester. I feel that they are necessary and have continued them 3 x a week but with only 1/4 cup. Thank you so much for hanging in there if you have read my postings and for any input.I’ve learned a lot from the articles and comments but am still learning.

    • Sheri May 26, 2013 at 8:35 pm # Reply

      Oops, I meant to say that I saw a women in one of your posting who used 100 mg of natto k a.m. and p.m. instead of aspirin and/or lovenx and it worked for her.

      I hope that taking the methylb12 will help with my elevated folate (took metafolin), when I was taking 1600 mg in the past. I really feel that I have a problem with clotting since my periods were very clotty before my pregnancies and have gotten worse and shorter over the last 8 years. Since I can’t take Homocystex during pregnancy due to the high amounths of TMG, I hope that getting the proper amount of methylfolate and methylb12 will help with possible factors (e.g. s-adenosylhomocysteine, etc.) that may also influence clotting factors, especially during pregnancy when it seems the autoimmune system goes into overdrive.

      • Sheri January 11, 2014 at 10:27 pm # Reply

        Update: I am 40 weeks 1 day pregnant today. I took raw prenatal vitamins (Vitamin Code) and pharmaceutical grade fish oil the entire pregnancy. I watched what I ate and took vitamin E and/or vitamin k2 when I ate food on the clotting list they give to people who take warfarin. I also stayed away from green tea that has been said to effect folate absorbancy. I didn’t take the 4 mg of folic acid prescribed by my dr. My subchorionic bleed was compleyely gone by 20 weeks. I did bedrest for about 12 weeks and took it easy til it was gone. I think the Wobenzyn was too much in the beginning. I just wanted to give an update. I also started water aerobics, took epson salt baths, ate mostly organic and used organic products, and drank red raspberry tea the third trimester. Hope delivery goes well!

  56. Colleen May 31, 2013 at 4:20 pm # Reply

    Hi Dr. Ben,

    I’m a 33 yr old TTC, 2 previous miscarriages, an insulin dependent Type 1 Diabetic and have the MTHRF Heter A1298c gene. Would you suggest any additional supplements to the above mentioned (including Xymogen Prenatal).

    Thanks a million for all of your work!
    Colleen

  57. Meghann June 8, 2013 at 3:07 am # Reply

    I am heterozygous for the A1298C mutation and found out after losing my last baby. I have one healthy baby and my last baby had a neural tube defect discovered at 15 weeks. With my first pregnancy, I took Neevo DHA. My latest pregnancy, I was taking Rainbow Light prenatals and an extra 400mg of folic acid (just because I wanted to make sure to have enough). My doctor has recommended neuromethylation cream which has 5-mthf in addition to continue taking the rainbow light prenatal, vit d drops, vit c 500mg, a probiotic and a digestive enzyme. I see that your recommendations are different. How does this cream compare to the sublingual that you recommend?

  58. Devyn June 12, 2013 at 1:16 am # Reply

    I sadly had a 3rd miscarriage in March and am now going to try NeevoDha. I was diagnosed with a single mutation of the C677T in April and no Dr.’s seem to think it’s a big deal which is crazy to me. I’m trying to be proactive with my own health and future pregnancies at this point and just wanted to know what else I should be taking in addition to the NeevoDha since this recent diagnosis. I’m so confused. Thank you.

  59. Anna July 8, 2013 at 1:28 am # Reply

    Hi Dr. Ben,

    Regrettably I cannot listen to the podcast, so I have to do only with the written info on your website. I am just a bit confused about the prenatal list. Do you recommend to take 1 to 10 supplements PLUS a prenatal multi vitamin such as Thorne? Or is it either/or?
    I have compound heterozygenous MTHFR (just found out two weeks ago), I am 5,5 weeks pregnant currently and I want to give this little one the best chance at life, but I am just a bit confused. Hope you can help me out. (or anyone else who knows the answer)

    Currently I am on folinic acid (385 hm?) and I take 100mg of aspirin. I try to eat as much green leafy veggies and lentils as possible, but I am so worried it is not enough. I have just ordered the Thorne Prenatal last week, waiting for it to arrive.

    Should I add methylB12 to it? Should I add P5P to it? It looks to me the required doses are already in the multi vitamins, but I am not sure.

    Also, some people have suggested Lovenox to me, but my doctor told me I don’t have a blood clotting disorder, so not sure if I should have this blood thinner?

    I have had two early miscarriages and two missed abortions in a row. Four years ago I did give birth to two little boys who are healthy now, but I had severe pre eclampsie and my boys were very much under fed when they were born. Now I recently have been given diagnose of low egg cell reserve (feels like this might be my last chance) and MTHFR.

    So far, I have been unable to find a doctor here in Perth, Western Australia, who takes this gene serious and is willing to help me out. It has caused a proper panic in me, as I really want to do the right thing, but I just can’t figure out exactly what that is. I hope someone here can help me figure this thing out.

    Thanks for your time, Anna

  60. Allison Garfinkel July 21, 2013 at 1:50 am # Reply

    I am concerned about taking vitamin K when I am homozygous MTHFR 677. Doesn’t vitamin K promote blood clotting? I am trying to conceive, just had my second miscarriage and my doctor wants me to take daily baby aspirin and possibly lovenox to prevent potential clotting issues in early pregnancy which he suspects to be the issue. I was prescribed Neevo DHA but after listening to your podcast it sounds inferior to the other prenatals you’ve recommended. Please explain further why vitamin K is necessary and not harmful in my situation. Thank you!

  61. Annemarie September 13, 2013 at 5:31 pm # Reply

    Hallo Dr Ben,

    I have just found out that I am A1298C Homozygous. I have a history of migraines with aura since early childhood. I am 35yrs old and have 3 sons. I had no miscarriages, but had severe pre eclampsia and HELLP syndrome with my 1st(born31wks) and 3rd son (29wks). With my middle son I had no problems and delivered @40wks. I took aspirin with pregnancy 2 and 3 and with no2 took high amounts of fish oils and ate Salmon almost every day. I took a little bit less fish oils with no 3. We really want more children, thus

    My questions are:

    1. I am willing to take every supplement as you listed it. Should I still take aspirin or lovenox?

    2.I have recently studied a supplement called Eckonia Cava Seanol that lowers the viscosity of the blood and is a great anti-oxidant. Can I add it to your list?

    3.What do you think of using a supplement that raises nitric oxide like a l-citrulline beetroot nitric oxide chewable?

    4.What do you think of using enzymes like Wobenzymes. I know there are some risks like miscarriage with some enzymes, but the other day I read an article that said you could use it through pregnancy.

    5. Could you do far-infrared sauna while pregnant?

    I really appreciate any of your recommendations. Thank you so much for taking the time to read this.

    Kind regards
    Annemarie
    South Africa

    1.

  62. Sarah September 15, 2013 at 2:54 am # Reply

    Dr. Ben,

    My husband and I are both homozygous for MTHFR C667t. We have been going through fertility treatments over the last year. Our RE said that as long as I take 3mg of folic acid and a baby aspirin daily we should be just fine in terms of the MTHFR. So I have been taking Actifolate from Metagenics. I take 3 tabs a day in addition to my prenatal vitamin. My husband also takes 2 actifolate a day. In addition, he and I have both been found to be vitamin D deficient and have been on supplements off and on for this. I have talked to my RE about my concerns about possible autoimmune problems that may also be affecting our fertility. He mentioned possibly adding heparin/lovenox after our IVF transfer. I guess I have the following question, Is actifolate sufficient or should I be on a different folic acid supplement? The last thing I want to do is go through our final attempt at IVF with ICSI and have it fail because I am not receiving the right type/amount of folic acid. Thanks in advance for your help.

  63. Sarah November 4, 2013 at 8:52 pm # Reply

    Dear Dr. Ben,
    I am Compund Heterozygous and have Factor II. I have had 2 miss-carriages in the past 4 years, one failed IUI, and will start a new IUI this month.
    I take 1 Baby Aspirin, 1MG of L-5-MTHF, and Thorne Prenatal. Is this enough for my gene mutation? I used to be on 15MG of Deplin(generic) and Neevho DHA and my OBGYN said this was way too much. Can you please advise me if what I’m taking is correct and will help me have a successful pregnancy? This is all so confusing and a lot of Dr.’s here do not know very much about this mutuation or give you different answers. I do not want to miss-carry again due to this mutation. When I do become pregnant my RE will have me take Lovenex for the first trimester as well.

    Thanks! Sarah

    • Cassie November 5, 2013 at 11:07 pm # Reply

      Sarah,
      For the Factor II you probably should add Lovenox or another similar anticoagulant. Factor II is very similar in clotting nature to Factor V Leiden (which I also have along w/one of the MTHFRs). FVL is routinely treated prophylactically with anti-coags in pregnancy. Feel free to message me off the group if you have questions about it. I have taken it in 2 pregnanancies after having a 2 losses and a 29w preemie without it.
      Cassie

  64. Julia November 17, 2013 at 6:05 am # Reply

    Hi Dr. Lynch, I have a question for you about prenatal supplementation.

    My husband and I have started our first IVF cycle and we have never been tested for MTHFR, but I would like to be after reading more about it. It looks like the test takes 6-8 weeks for processing, however. My RE has prescribed Folic Acid 1mg/day but this appears to be synthetic and non-methylated. Would you recommend I take some methylated folate in addition to or instead of what was prescribed as a precaution? If I take the methylated form, does it do any good to take the prescription I have? As I read through some of the symptoms, some of them hit home and I’d like to do everything possible to make this attempt a success and protect the health of my offspring. Thank you so much!

  65. Adriana January 11, 2014 at 9:36 am # Reply

    Hello Dr. Ben,

    I have been tested positive for MTHFR C677T and MTHFR A1298C both heterozygous. I’ve lost 3 pregnancies. My doctor gave me Femibion which contains folic acid, Metafolin, vitamins and iodine. I also take 1000 mg Omega 3 per day. He said that I should also take 1 Clexane injection per day as soon as the pregnancy test turns positive until I give birth. Please be so kind and tell me your opinion about the treatment. Should I also take vitamin C and magnesium or anything else considering my problems? Thank you very much for your time and answer.

    • Maria April 13, 2014 at 6:22 pm # Reply

      Hi Adriana,

      I want to give you some hope :) I have suffered 2 miscarriages and been diagnosed as homozygous for MTHFR C677T (they checked for many other things but everything else was ok). I am 36 weeks pregnant now (very healthy so far) and i have been taken Femibion and low-molecular-weight heparin (as Clexane) the whole pregnancy. I also take 2000 mg Omega 3 per day. I am not a doctor, but i think the Femibion contains vitamin C and magnesium enough so you don´t need to supplement.

      Best of lucks with your next pregnancy!

  66. Julie January 26, 2014 at 2:56 am # Reply

    In your audio I heard you say for calcium could also take moringa. I was reading on this website: http://moringatreeoflife.com/About_Moringa.html to not use moringa flowers during pregnancy. I wasn’t sure if you had heard that.
    Anyway thank you for all of the valuable information!

  67. Erin January 27, 2014 at 3:11 am # Reply

    Hello Dr. Ben,

    I am homozygous C667T. Had 3 miscarriages before being diagnosed. I currently have 2 little ones and I’m nursing my baby. They gave me Folbic and VitaMed MD during my pregnancy but from one of your responses above I see that Folbic is insufficient. What should I be taking as a nursing mother? Thank you!

    Erin

  68. Heather January 30, 2014 at 9:23 pm # Reply

    Dear Dr. Ben,

    I was recently diagnosed with heterozygous A1298C MTHFR mutation. I am guessing the supplements you list above will be helpful for me, though my current OB only told me to take one baby aspirin daily (I am in the process of making an appointment with an RE as I have suffered a miscarriage and cannot emotionally go through that again). I am wondering what your suggestion is about how long I should be on this regimin before trying to conceive. This same OB told me we could conceive right away, as I am on my first cycle since the miscarriage. However, I am worried my body hasn’t built up all the nutrients it seems to be not absoring and/or missing. What is your recommendation? Thank you so much.

  69. Nicole Oldfather February 14, 2014 at 3:52 am # Reply

    Dr. Ben
    I had a healthy baby in 2001, but he was induced early d/t pre-eclampsia. Then in March 2005 I miscarried at 23 weeks, however they said the baby measured at 17 weeks. Again in Nov 2005 I miscarried at 16 weeks, baby measure 13 weeks. I was then tested for clotting disorders and had genetic testing done. The only thing found was MTHFR, but I don’t know what type. In Feb 2006 I got pregnant with my daughter and saw a perinatologist who put me on Lovenox, but said MTHFR had nothing to do with my losses and my ob/gyn believed the same thing. She was born healthy and no pre eclampsia that time. Then in Nov 2013 I was 18 weeks and lost the baby. I had been taking Heparin since I found out I was pregnant. That time I was seeing a maternal fetal medicine specialist who also did not believe that MTHFR had anything to do with my losses and she didn’t even want me to take the Heparin, but my ob doc agreed to keep prescribing it for me anyway. After the loss my ob/gyn told that if I got pregnant again she would not prescribe the Heparin since I miscarried even though I was taking it. Could you comment on blood thinners and still miscarrying? Also, I would like to have another child, I’m 37, but every doctor I have been to thinks that MTHFR is nothing to be concerned about, it’s very frustrating. I am just now really educating myself through your website. I think I saw mentioned that you do phone consultations, is that correct?

  70. Stephanie February 15, 2014 at 3:18 am # Reply

    What is a good iron supplement since the Optimal Prenatal doesn’t have any? The one I took while pregnant with my daughter was Mega Food and has folate and vitamin b-12 in it. My iron levels during both my pregnancies have been low so I know I need extra. Thank you!

  71. Kimberly March 4, 2014 at 1:24 pm # Reply

    You stated with regards to Sublingual B12: “Sublingual Active B12 with Methylfolate: provides 1 mg of methylfolate and 800 mcg of methylfolate in a small sublingual tablet.

    I think you meant to said 1mg methylcobalamin and 800mcg methylfolate. :-)

    • Dr Lynch March 4, 2014 at 10:18 pm # Reply

      Hey Kimberly – yes – you are right :) Good catch – I will fix

  72. Michelle April 5, 2014 at 9:14 pm # Reply

    Dear Dr. Lynch,

    After being diagnosed with MTHFR heterozygous C677T with ACE deletion homozygous the hematologist I went to advised me that he didn’t think it would be possible for me to get pregnant. The fertility doctor I was seeing thought by implanting the embryo she could circumvent the issue, but after undergoing a failed IVF cycle and then trying on my own, I can tell that the embryo is trying to attach, but haven’t been able to obtain a positive test and end up losing it after being a week late in my cycle. Through all of this, I’ve also discovered that I can’t take baby aspirin, Lovenox or the other typically prescribed blood thinners, due to my allergy to NSAIDS. I tried Vitamin E, but broke out in red spots on my face. I saw Nattokinnase on one of your lists, but I’m unsure of how much I should take and if there are any associated risks. I feel like the Nattokinnase may be my last hope. I have been taking Neevo, Glutathione, DHEA and COQ10 for over 6 months now as recommended by the fertility dr. I also take Zyrtec-D and Zantac for my allergies and get allergy shots every 3-4 weeks, which my doctors seemed to think it would be ok to continue if I were to get pregnant. Any suggestions you could make would be greatly appreciated.

  73. Cassie April 8, 2014 at 1:50 am # Reply

    Michelle,
    Have you tried Arixtra? It is a synthetic LMWH that people take when they are allergic to Lovenox.

    I take nattokinase regularly. I was taking it at the beginning of my last pregnancy along with Lovenox. I emailed a doctor who had done research on natto and felt like it was safe for pregnancy. If you look way back thru the history of it, it has been used thousands of years in eastern medicine for pregnancy, the real natto food that is.
    I was still nervous about taking too much so I cut out the natto and stayed on the Lovenox. Exactly a week later I had a superficial clot in my leg ( I have FVL in addition to MTHFR). I ended up on a triple dose of Lovenox as a result.

    Cassie

  74. Lauren April 10, 2014 at 1:11 pm # Reply

    Hello, I am quite nervous after finding your past writings. I had 2 miscarriages last year, one @ about 6 weeks and one @ 9 weeks after the heart had developed and we had seen the baby, however the heart was never strong. I was tested for the standard bloodworm at my OB and discovered I had the A1298C mutation. I then went to my wellness dr and had a ton of blood work done. My serum folate was >24.0, vitamin b-12 996, homocysteine 6.0.
    I am currently taking 200 mg progesterone, raw prenatal vitamins (contain .8 folic acid) and Nordic naturals fish oil. I have been taking 1mg folic acid since week 3 – I believe now it was a blind prescpition writing – meaning – you have mthfr- and I don’t know much about it- so here is folic acid. I’m 6.5 weeks and haven’t taken my folic acid this am. I’m scared to take it- after reading this page & other info re autism and excess folic acid…
    Thoughts? Please help!
    Thank you, Lauren

    • Lauren April 10, 2014 at 6:36 pm # Reply

      Correction – my prenatal is 800 mcg folate

  75. Maria April 13, 2014 at 6:08 pm # Reply

    Hi Dr Lynch,

    I am a 29 years-old that has suffered 2 early miscarriages (after seeing healthy heart beat). After my second miscarriage i was diagnosed homozygous C677T for MTHFR. I live in Spain and I am currently pregnant, I am taking Femibion 2 (with Metafolin) and low-molecular-weight heparin. I am soon moving to Australia, and I’ve seen that i will not be able to buy Femibion there. Could you advice me what prenatal multivitamin or just what metafolin supplement could i buy in Australia? I´d appreciate advice from people from Australia too :)

    Thanks you for a wonderful webpage!

Trackbacks/Pingbacks

  1. Read this First! | | MTHFR.NetMTHFR.Net - January 27, 2012

    [...] Prenatal Supplementation with MTHFR [...]

  2. Using Personal Experiences as Part of Research. | Scientific Mamma - July 15, 2013

    [...] miscarriages. Many of these women have another thing in common. They are trying to follow the protocol Dr. Lynch lays out on MTHFR.net. The link will take you to his podcast where he discusses the [...]

  3. Preparing For Pregnancy With MTHFR Mutations • MTHFR Living - November 13, 2013

    […] The good news is that there is a lot that you can do to ensure healthy outcomes for you and your family when trying to become pregnant. The first thing will be to ensure that you and your partner are methylating properly and receiving the correct nutritional support. […]

  4. Older Mothers Put a Strain on Midwives (Commentary on the Guardian-UK Article) | Mothering in the Middle - January 9, 2014

    […] Mthfr.net gives a pretty good list of the pathology associated with folic acid use. And the nutrition that optimized well-being: http://mthfr.net/prenatal-supplementation-optimizing-your-future-child/2012/01/20/ […]

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