Prenatal Supplementation: Optimizing your Future Child

UPDATE: February 4, 2015


My wife, Nadia, and baby, Tasman, in a Russian village.

As a father of three healthy and beautiful boys (I think so anyway), I know I am very fortunate. I am thankful for this each day and never take it for granted.

As a physician, I’ve worked with many men and women who had been trying unsuccessfully to have a child.

As a physician, I’ve worked with many men and women who have children with significant birth defects or are somewhere on the spectrum.

As a soccer coach, I work with kids who are struggling mentally and physically. It pains me because I know I can do something about it. Yet the parents have no clue or no desire for alternatives beyond medications.

My passion is to reduce the incidence of disease in unborn children.

This is what gets me up and out of bed and excited to go to ‘work’.

Do you believe it is possible to reduce the incidence of disease or birth defects in unborn children?

Have you miscarried in the past or having difficulty with fertility?

Have a child who is on the spectrum, down syndrome, hypospadia, tongue tie, congenital heart defects .  . .

Many birth defects or significant pediatric conditions are caused by inadequate nutrition before, during and after pregnancy.

If unprepared, methylation gets imbalanced.

Those with MTHFR defects are significantly more prone to imbalanced methylation.

Learn about how genetics, lifestyle and diet contribute to issues during pregnancy – AND how to optimize them for a healthy pregnancy – and thus a healthy baby:

Prenatal-Conference-700a1‘Maternal and Pediatric Implications of MTHFR and Methylation Dysfunction.”

This scientifically-backed, irrefutable 90 minute presentation empowers you to significantly reduce the risk of countless problems – including autism, down syndrome, neural tube defects, congenital heart defects and others.




Prenatal Supplementation: Optimizing your Future Child  

    • General supplement recommendations for those who are pregnant, regardless of the MTHFR mutation
    • Provides insight into which supplements are needed while pregnant….and…why.
    • Provides dietary suggestions to increase calcium and magnesium levels.
    • Explains the importance of why nutrients are so critical during pregnancy
    • Provides specific supplement recommendations along with suggested amounts and when to take.

Download to your iPod or listen later:
Download podcast (right click your mouse and select ‘Save as’)

Supplements to Consider (in addition to a healthy well-rounded diet and lifestyle):

  1. Optimal Prenatal: provides a blend of active folates along with other key nutrients
  2. or Optimal Prenatal Protein Powder: Make a smoothie in the morning instead of swallowing pills. This is the only prenatal protein powder available in the world that I am aware of. Optimal Prenatal Protein Powder provides all vitamin, minerals and additional specialty nutrients to help optimize pregnancy.
  3. Active CoQH: provides 50 mg of pure ubiquinol in small easy-to-swallow gelatin capsules. Soy free. Best to take with food anytime of day. Consider 1 daily. This is already in the Optimal Prenatal so you may not need more.
  4. Sublingual Active B12 with Methylfolate: provides 800 mcg of methylfolate and 1000 mcg of vitamin B12 (800 mcg of methylcobalamin and 200 mcg of adenosylcobalamin) in a small sublingual tablet. Consider placing 1 tablet under the tongue in the morning upon rising and another 30 minutes before lunch. Your physician may desire you to take 2 tablets under the tongue twice a day. Vegetarian.
  5. L-5-MTHF: provides 1 mg of methylfolate as Metafolin. Take as directed by your healthcare professional. Useful to increase your methylfolate levels incrementally if higher amounts are needed or recommended by your physician.
    • OR L-5-MTHF Lozenge: provides 1 mg of methylfolate as Quatrefolic in an easy-to-deliver lozenge. Lozenge may be broken into smaller pieces for smaller doses.
  6. Optimal Vitamin D Liquid: provides 2,000 IU of vitamin D3 in a pure base of extra virgin olive oil. Kosher ingredients. Vegetarian. Consider taking 3 drops daily or 21 drops once a week. Recommended to take 6,000 IU of vitamin D3 daily while pregnant and breastfeeding. Have your physician monitor your vitamin D blood levels.
  7. ProBiota 12 Powder: provides 50 billion beneficial bacteria in 12 strains in a great tasting powder that is easy to tolerate. Simply take 1/8th teaspoon and place directly into your mouth after dinner nightly.
  8. Chewable Cal/Mag Plus D: provides 25% of daily calcium and 25% of daily magnesium per chewable tablet. Consider chewing one with lunch and dinner.
  9. OR Optimal Chia Seeds: provides additional food-based calcium, magnesium and trace minerals – and protein – in a very healthy form. Consider making Chia Seed Gel in the evening and taking 1 tablespoon between meals to help absorb toxins and encourage healthy bowel movements.
  10. Optimal Vitamin E: provides 400 IU of mixed tocopherals in an easy-to-swallow gelatin capsule. Vitamin E is an excellent antioxidant and also supports healthy blood flow. This is already in Optimal Prenatal so you may not need more – and one should not take excessive amounts of vitamin E.
  11. Optimal Fish Oil: provides potent amounts of EPA/DHA in the triglyceride form which is better absorbed than the ethyl ester forms. Consider taking 2 capsules daily with a meal anytime of day.
    • OR Optimal Fish Oil Liquid: provides EPA/DHA in an excellent tasting liquid that may be added to smoothies or taken straight with some food. Consider taking 1 tablespoon daily.
    • OR Optimal DHA (Vegan): provides 400 mg per serving of vegan DHA which is non-GMO. Also provides phospholipids.
  12. Optimal PC or Optimal PC capsules: For those having methylation deficiencies, especially MTHFR, BHMT or PEMT, consider a phospholipid complex which provides phosphatidylcholine and other key phospatidyl derivates. Choline deficiency is extremely common in pregnant and breastfeeding mothers. We do not want choline deficiencies as it is a critical nutrient for cognitive development.

QUICK FACT: Only 15% of pregnant women have adequate choline levels! This is shocking and must change. This is why I highly recommend Optimal PC and Optimal Prenatal. Choline is found in both.

Prenatal Multivitamins:
There are very few prenatals that meet a high enough standard for me to recommend.


  • Most use synthetic folic acid. This is NOT supportive for women having genetic problems in the folate pathway. (I fully explain this in the Prenatal Conference video)
  • Tablets. I am not a fan of tablets as they do not dissolve well in the digestive system. This means that the nutrients packed into tablets are typically not that bioavailable. When a manufacturing facility produces tablets, it literally sounds like a jackhammer. The force used to compress the nutrients into the stone-like tablet is tremendous. This is far from ideal when the goal is delivering nutrients.
  • Insufficient. The one-a-day prenatal or prenatal ‘gummy’ are great marketing schemes for women who dislike taking pills during pregnancy. I totally understand. My wife and I have three boys. I heard her mention MANY times that she didn’t like taking the pills as they made her nauseated or were hard to swallow. (This is why I made the Optimal Prenatal Protein Powder. Only wish I made it 13 years ago…). The problem with too few capsules is the pregnant woman is not going to obtain adequate nutrition for HER and the developing BABY. Pregnancy is an extremely demanding time and demanding times require more nutrition. Period.
  • Vitamin and mineral forms are weak to worthless. There are certain forms which are more available than others. Folic acid is one such example. Why use folic acid when there are more bioavailable forms now – folinic acid and methylfolate? Price. That’s the only reason. Using chelated minerals is way more effective than using minerals that are not bound to an amino acid. These chelated minerals are easier on the digestive system which means less constipation, less stomach aches, less nausea and more absorption in the blood. I could go on and on here but I will stop.

The following are the prenatal vitamins I formulated based on my years of research.

To give you some perspective, it took me three years to formulate these. I did not rush it. A prenatal is far too important to rush.

  • Optimal Prenatal: provides 800 mcg of methylfolate and folinic acid for best folate support. Using only methylfolate in a prenatal is not recommended. This is iron-free. It is iron-free because iron competes with calcium and also many women need varying amounts of iron during pregnancy. Some need none and some need quite a bit. Use Optimal Iron Plus Cofactors for a well-tolerated iron supplement. I designed this for my wife as she couldn’t tolerate any iron. Thankfully this one she does.
  • Optimal Prenatal Protein Powder: provides the same nutrients as above in a complete protein smoothie. Simply add a scoop of this to your morning smoothie and you’re done with your prenatal. It takes more than vitamins and minerals to have a healthy pregnancy. It also requires adequate protein. This prenatal protein powder also provides additional nutrients such as L-carnitine (which the capsules do not).

My three boys: Theodor, Tasman and Mathew


Critical Prenatal Supplementation:
Many ask me, “Do I have to take all of those supplements?”


They are merely recommendations.

The recommendations vary upon your:

  • lifestyle (more relaxed, less stressed)
  • diet (eat fermented foods so may not need probiotics, almond milk so may not need calcium)
  • environmental surroundings (full sun – don’t need more D3 if you are exposed to it)
  • medications (no antacids so may need less B12, no valproic acid so may need less folate)

The critical supplements to take – even for a perfectly healthy woman with no symptoms or conditions:

  • Optimal Prenatal or Optimal Prenatal Protein Powder.
    • I prefer the Optimal Prenatal Protein Powder because it is so comprehensive, easy to make and one is more likely to get all their vitamins and minerals for the day in a single smoothie.
    • The Optimal Prenatal capsules are great, too, but more work to remember.
  • Optimal PC
    • Since only 15% of pregnant women have adequate choline levels, I truly believe all women need to be supplementing with choline.
  • Optimal Fish Oil or Optimal Fish Oil Liquid
    • EPA and DHA are critical for healthy membranes. Again, I believe this one is critical as most people are deficient in these nutrients.
  • Optimal Vitamin D Liquid Drops
    • This is still a major deficiency for most people. During pregnancy and breast feeding, it is recommended to take a minimum of 6,000 IU a day and up to 10,000 IU a day. Optimal Vitamin D provides 2,000 IU per DROP and may be taken once a week. You can take 3 drops x 7 days = 21 drops once a week and then not take it again until end of next week. Of course, you need to discuss this with your physician – along with all the other recommendations.

These four supplements are the most critical.

If you get the Seeking Health Membership, you can save 10% on each purchase for a year. This adds up.

Keep in mind that prenatal supplementation is also needed during breast feeding.


You are still nourishing yourself and your beautiful baby.

If you stop nourishing yourself, you will become depleted, possibly depressed and baby will potentially have methylation dysfunction.

These are things we must avoid.


Yes! For many.

I would LOVE to hear how this prenatal supplementation protocol has helped you throughout pregnancy and during breast feeding.

I received this amazing comment today via Facebook:

I used this protocol after 4 miscarriages and am now 32 weeks pregnant with our little angel! Your work is inspiring and amazing!

How has it worked for you? Please do comment and share!

Others need to experience a healthy and rewarding pregnancy – and the little stinkers after they are born!

Disclaimer: The information and product suggestions presented here are merely suggestions for you to consider. This information is not a prescription, treatment or diagnosis. Follow the suggestions and use the suggested supplements at your own risk. It is highly recommended that you discuss this information with your physician. Always seek the advice from your healthcare professional.

Find a physician who understands MTHFR and methylation dysfunction.
Physicians and health professionals listed at Seeking Health Educational Institute have received training from me.

Find a health professional here in the Physician Directory.

, ,

247 Responses to “Prenatal Supplementation: Optimizing your Future Child”

  1. Cassie January 20, 2012 at 11:08 pm # Reply

    Some doctors are recognizing now that LMWHs and/or heparin are necessary with MTHFR. If someone were taking either of these during pregnancy, would you change any of your recommendations above for supplements. In other words, would any of them conflict or would you need more of some b/c of being on anti-coags?

    • Dr Ben January 20, 2012 at 11:24 pm # Reply

      Cassie –

      Great question.

      You may have to reduce the Optimal Fish Oil down and identify a pure DHA supplement. Optimal DHA by Seeking Health is a vegan-based pure DHA supplement which is in a base of phospholipids.

      All the other nutrients are fine to take while on blood thinners – including Optimal Krill Oil. There is not enough EPA/DHA in Optimal Krill Oil to pose a problem for most women.

      Definitely talk with your OB/GYN and physician and obtain their thoughts on the matter.

  2. Christa January 21, 2012 at 5:22 pm # Reply

    Ok so it is ok to take NeevoDHA plus the Optimal Chewable Vitamin together? I also want to take the Probiota 12 powder.

    I was diagnosed with a vitamin d deficiency and took 50,000 mg per week for 12 wks. It hardly did anything. Should I take an additional calcium and d3 supplement in addition to all the above?


    • Dr Ben January 23, 2012 at 6:30 am # Reply

      Christa –

      It is ok to take the Optimal Mutltivitamin Chewable and the NeevoDHA together. The ProBiota 12 Powder is also fine to take – and highly recommended.

      The question I pose is what form of Vitamin D3 were you taking and why didn’t your levels rise? I highly recommend you try taking Vitamin D360 and taking 6,000 IU to 10,000 IU a day which is 3 to 5 DROPS. Make sure you have your doctor measure your vitamin D levels and discuss this dose with them. The 6,000 IU a day is totally fine while pregnant. The 10,000 IU is also likely ok but it is pushing it.

      You should take an additional Cal/Mag supplement while pregnant. This will help the vitamin D3 absorption and also help prevent calcium loss from your bones – and leaching of lead from your bones as well. Consider chewing 2 tablets of Calcium Magnesium Plus D3 Chewables twice a day – breakfast and dinner or lunch and dinner or anytime of day.

      I also highly recommend the Active CoQH and Optimal Krill Oil – to truly support your developing child’s neurological system.

      • Christa January 24, 2012 at 12:08 am # Reply

        The vitamin D deficiency has been going on for a long time. In the beginning I also had anemia. Ferritin and iron was low. Anemia seems to be better according to lab results.

        Year 1-vitamin d-sub for Drisdol 50,000 units
        Year 2-D3-50-BIOTECH
        Year 3-vitamin d-50,000 same as above

        Today, 1-23-12, doc called to say vitamin d is extremely low again. What is going on?

        To this day, for three years, my vitamin d levels will not increase. It is a mystery that I do not like. I live in FL for goodness sakes with lots of sun. No one can explain it.

        They were going to call in a prescription for 50,000 u. I told them that I cannot because I am pregnant. So waiting on return call about that.

        I will take this information to my doctor and see what she says. Thanks for your advice and wisdom.

        • Dr Ben January 24, 2012 at 1:44 am # Reply

          Christa –

          Drisdol is vitamin D2. Not a good form of vitamin D.

          I am suspecting too high of a dose of D3 taken at one time and also low stomach acid or bile secretion PLUS iron deficiency. If you take so much vitamin D3 at once vs a smaller amount each day, that may help increase your vitamin D3 levels.

          Read the study on vitamin D3 and iron deficiency. They are linked.

          Iron deficiency is linked to poor vitamin D3 absorption. Consider taking 1 capsule of Optimal Iron Plus Cofactors daily on an empty stomach – first thing on rising.

          This is why I recommend you consider taking 10,000 IU of Vitamin D3 daily in the form of liquid vitamin D3. Very well absorbed and you place it directly on your tongue.

          • Christa January 24, 2012 at 2:05 am #

            Thanks for all your help. I am going to try and find a doctor to listen and believe me. My progesterone levels are at 8.1 and my hcg @ 600 at 5w1d. It doesn’t look good right now. This will be my 4th miscarriage, but what I have learned in the last month about MTHFR and other factors, I believe there is hope for the future. I just need to find a doctor who will truly listen and believe my symptoms.

        • Jen Aliano August 6, 2012 at 4:52 pm # Reply

          Hi Christa,

          I just wanted to note that Magnesium deficiency can often be the cause of vitamin D levels not rising despite supplementation. There are several other cofactors. Here is some easy reading you might want to consider:

          Thanks Dr. Ben for this post! Great information!!

          For those of you who would like to ‘DO’ something about the major vitamin D deficiency epidemic that affects a majority of pregnant women, please also check out The information that Dr. Ben and very few others provide about the necessity of vitamin D during pregnancy, especially, is priceless. We (GrassrootsHealth) are trying to make this information mainstream and available to ALL pregnant women.


  3. Ann January 23, 2012 at 6:47 pm # Reply

    Thank you for this. I had sent a message to the “contact us” page, but realized that was probably the wrong place. Anyway, I had two miscarriages, got diagnosed Compound Hetero MTHFR. I took 2 folbic, Neevo, and Baby Aspirin and about 5 grams of Fish oil a day. I had a healthy baby in August. Now I’m trying to get pregnant again, and after reading your website, I’m thinking the Folbic may be the wrong thing to take (even though it seemed to work) and I’m afraid the Neevo by itself isn’t enough. I just ordered the L-5-MTHF and the Sublingual Active B12 with Methylfolate. I’m currently taking the original (Pink Pill) Neevo, CAL/Mag/vitd, Vitamin C, and about 2.5 grams of Fish Oil, and a probiotic. Would it be safe to add both supplements, making my L-MTHF 2,800mcg. or should I just start with the B12, making my L-MTHF only 1,800mcg? I called PamLabs, and they told me the B12 in the pink Neevo is not the active form so I’m assuming it’s doing nothing for me. I’d love to know your thoughts. Thanks!

    • Dr Ben January 23, 2012 at 11:13 pm # Reply

      Hi Ann –

      Folbic contains standard folic acid, poor form of B12 and B6. Given that 2 x Folbic contains 5 mg of folic acid and L-5-MTHF is much more potent than folic acid, I would start out with the Active B12 with Methylfolate and Neevo for now. You are also getting the active B12 form of methylcobalamin vs cyanocobalamin which is going to make your methylation cycle work much better than if it was using cyanocobalamin.

      I would add the Active CoQH and Optimal Krill Oil.

      I would also add in the Optimal Multivitamin Chewable as it contains a complete B complex along with complete minerals – which you need and so does your little developing one. Neevo does not contain comprehensive minerals or B vitamins.

      Make sure you take the Vitamin C at least 1 hr away from Neevo and the Sublingual B12 with Methylfolate. Vitamin C in excess of 250 mg can destroy vitamin B12.

      Make sure you also take about 6,000 IU of Vitamin D3 daily.

      I know it may seem like a lot of nutrients, but we are not only trying to prevent miscarriage – we are trying to provide your developing child with the best genetics possible. That is my ultimate goal.

  4. mrsjukian January 27, 2012 at 11:50 pm # Reply

    Hi Dr. Ben,
    I am homozygous C667T, and also have Hashimoto’s hypothyroiditis. Recently went gluten free after reading a great book called “Why do I still have thyroid symptoms when my lab tests are normal”. Have had 3 miscarriages, all under 6 weeks.

    My holistic doctor is recommending that i get nutritional testing done with SpectraCell. I have had this done two years in a row, but recently my thyroid doctor scoffed at it. Do you think this test is good enough to find out what nutrients i’m deficient of, or is it a waste of money?

  5. Dolores February 25, 2012 at 12:12 am # Reply

    Greetings Dr.Ben ~ I’m homozygous C677t and about to see a specialist for supplementation layout .. How long do u suggest we implement these supplements before we TTC again. Thank you. We look forward to helping others with a success story and a baby blessing very soon ;)

    • Dr Ben February 25, 2012 at 12:17 am # Reply

      Dolores –

      I recommend you do most of those suggestions – if not all – even while you are pregnant ;)

      Look forward to hearing your success story and seeing a photo!

      • Dolores February 25, 2012 at 12:29 am # Reply

        Thank u kindly for your help! Definitely hope to continue throughout va whole pregnancy — just curious if you suggested we run the supplements for a period of time before we start trying to,conceive again ?! I’ve heard various opinions 30-100 days of shops in system prior to getting pg again. Thanks again. Havea great weekend

  6. April February 27, 2012 at 7:06 pm # Reply

    Dr. Ben,

    I am A1298C Homozygous. I’ve had 2 misscarriages, one successful pregnancy and I’ve had a PE. I’m currently pregnant and taking Lovenox, Metanx, Biotin, Iron, and a chewable calcium supplement. I’m thinking about replacing my calcium supplement with the Calcium and Magnesium supplement.

    I’m on a limited budget. Unfortunately I cannot afford all of the supplements you have suggested, so I need to pick and choose. Which supplements are the most important that you think I cannot go without?

    • Dr Ben February 28, 2012 at 7:17 am # Reply

      April –

      Tough question for me as I’ve already thought this through to be as limited as possible. I will do my best but I truly don’t like limiting it as it requires a multifaceted approach to optimizing pregnancy.

      Why you taking Biotin?

      I would choose:
      – Optimal Fish Oil
      – ProBiota 12
      – Cal/Mag supplement
      – D3
      – Optimal Multivitamin chewable

      Probiotics are huge as are the oils and comprehensive multi.

      Have your doctor measure your ammonia levels. If they are elevated, then you need to reduce your protein intake a little – not much – and to also supplement with BH4 – which can be quite expensive.

      • April February 28, 2012 at 6:01 pm # Reply

        I’m taking Biotin because my doctor suggested it. My hair was falling out and my nails were weak. It seems to be helping.

        I appreciate you narrowing it down for me. I can at least start out with the supplements you listed. Thank you for you help.

        • Dr Ben February 28, 2012 at 6:03 pm # Reply

          April –

          Makes sense for the biotin.

          Do have your doctor check your thyroid:
          – TSH
          – T3
          – T4
          – anti-TPO
          – anti-TG

          • April February 28, 2012 at 6:16 pm #

            I know I just had my thyroid checked. I will see if I can get a copy of my test results. Thanks for the suggestion.

  7. Victoria February 29, 2012 at 10:33 pm # Reply

    Dr. Ben,
    I have a few questions for you:
    I have had 2 misscarriages in the past 4 months. One at 6 weeks and the other was discovered at my 8 week u/s and the babies only measured at 6w3d. I asked my doctor to test me for clotting factors because I could not undergo another loss. My blood work came back positive for MTHFR Hetro C677T and A1298C. My doctor said I will start Lovenox the next time I am pregant. I am taking Citra Natal 90 DHA prenatals. After researching some I asked my doctor to put me on Folgard also and she is going to call that in for me. Do you have any other suggestions for me as far as a pregnancy goes with this routine of Vit’s and lovenox? She also said I can supplement both Vit’s to bring my B6 to 100mg/day and B12 to 250mcg/day. All of this was due to my request, she openly admitted she knows very little about MTHFR.
    Second question, I am going to make an appointment with an internist to discuss this condition and how I need to treat myself when I am not pregnant. Should I ask for a homocystine level to be done? And if so, should this be done before I start the prenatal and folgard routine? What are the best treatments for this mutation and what is my risk with having it? I am worried because no doctors I talk to know anything but what I tell them I have read online and every article is different. Please help, I am desprate!! Thank you and bless your heart.

    • Dr Ben March 1, 2012 at 8:09 am # Reply

      Victoria –

      Please listen to the podcast here on this article.

      I also encourage you to read the article in full. Many of the questions you asked are answered here.

      I highly caution you about taking 100 mg of B6 daily – that is a lot – especially if you are taking the active P-5-P form.

      Folgard is not my recommended med of choice for MTHFR as it does not contain the right nutrients in my mind. Metanx is the best. However, both of these contain a lot of fillers and garbage.

      Here is the other ingredients found in Folgard:
      Other ingredientes: dicalcium phosphate, microcrystalline cellulose, corn starch, sodium starch glycolate, hypromellose, stearic acid, titanium dioxide, magnesium stearate, sodium citrate, polyethylene, glycol, citric acid, riboflavin, FD&C Blue#1 Lake, Silicon Dioxide, polysorbate 80, sodium benzoate, sorbic acid, carnauba wax.

      Homocysteine level can be ordered – sure. Even if it comes back normal, you have to take precautions.

      Also test your thyroid and female hormone levels – and testosterone. Progesterone must be checked now and once pregnant. Progesterone suppositories may be needed.

      Given your history of miscarriages, getting up to 2 mg or so of methylfolate daily would be ideal. Research states about 4 mg of folic acid to women with recurring miscarriages – but that is folic acid – not the most active form which is methylfolate.

  8. Jennifer March 2, 2012 at 7:52 pm # Reply

    Hi Dr. Ben,

    Would you recommend these same things for any woman of child-bearing age? My husband and I are not necessarily trying to conceive at the moment, but expect to be in the next couple years.

    Our daughter was stillborn at 37 weeks about a year and a half ago. After some testing, my perinatologist told us that I am heterozygous for the MTHFR gene and I also tested positive for all four anti phospholipid antibodies.

    After reading some of your information and listening to this podcast, I feel incredibly uneducated about my diagnoses.

    Right now I am taking a prenatal vitamin called Brainstrong and Folgard, but I don’t think that these two things are necessarily the right things for me to be taking. I want my body to be at optimal health for when we really do try to conceive again.

    Thanks for all of this information. It is so great to be able to read more about it. After reading this, either I didn’t know which questions to ask, or my doctor is not very educated about this mutation. Thanks very much for your time.

    • Dr Ben March 3, 2012 at 12:16 am # Reply

      Jennifer –

      Which MTHFR mutation you have? 1298 or 677?

      • Jennifer March 3, 2012 at 6:25 am # Reply

        To be honest, I don’t know. I will get a copy of my records on Monday. My doctor didn’t tell me a lot about it. Both my regular doctor and perinatologist gave me the impression that this was not something that would affect me other than when I’m pregnant. I’m feeling very misinformed. I will get back to you as soon as I know more. Thanks again for your time! :)

  9. Thera March 28, 2012 at 5:57 am # Reply

    I am homozygous c677t with advanced endometriosis and am experimenting with the supplements you recommend to find the right balance. I have recently gone gluten free and reduced dairy. My ob/gyn wants to put me on daily hcg shots to try to help me conceive. I’ve taken it before as a trigger shot with clomid but not on a daily basis. He doesn’t seem to know a lot about mthfr and I don’t want to do something that will make me worse off, I have a strong chemical sensitivity. Do you think that will interact with this condition?

    • Dr Ben March 28, 2012 at 6:15 am # Reply

      Thera –

      In my opinion, not a good idea to force conception right now. The likelihood of a miscarriage is too great with MTHFR and endometriosis. I say work on eliminating the endometriosis through lifestyle, diet and supplements and also address the MTHFR mutation.

      I can help you with both.

      I highly recommend a one hour consult to address both of these – along with the chemical sensitivity. Please call 800-547-9812 to schedule a consult. You may RSVP your consult here.

      I really want you to get pregnant naturally and develop your child healthfully for 9 months. The chances increase tremendously when the right things are addressed.

      • Thera March 29, 2012 at 7:43 pm # Reply

        Thank you, I agree as well. I would like to get my body as healthy as posible to be able to conceive naturally. I am going to schedule a consult, I just want to get a few more tests blood tests done first and maintain my new healthier diet and suplementation so I have a more comprehensive look at any obstacles I may have. Do you recommend Sun chorella as an additional nutrient to take? It looks like it is full of natural vitamins, algae, protein and is detoxing. I just didn’t know if there was anything in it that would interfer with MTHFR or the other supplements. Thank you!

  10. Amanda May 10, 2012 at 1:47 am # Reply

    I just found out I’m expecting and am already on most of your prenatal supplement protocol (coQH, krill oil, fish oil, vit D, probiotic, cal/mag, chia) but am still taking my one a day that contains food derived Bs (new chapter). I was also taking an active B complex (THORNE basic B complex), 1000mg sublingal methylcobalamin, and 1mg L-MTHF (THORNE) Anyways, my question is that I have been having terrible side effects of anxiety, depression, and heart palpitations when I take any of the active Bs. I no longer take them and want to try slowly tapering my way back up, but I’m worried about my pregnancy and want to get back into taking them as soon as possible. Would you still recommend me stopping all active B supplementation for a week or two and then easing back in? Is perhaps the actual supplements I’m taking causing some of the problem? Any input would be much appreciated! I want to do what’s right for my baby but I don’t want to have to fall into a pit of despair to do it! My mutation is single copy 677.

  11. Leslie May 20, 2012 at 6:56 pm # Reply

    Dr. Ben,

    I am Heterozygous for both C677T and A1298C and Factor V Leiden. It took 2 miscarriages to be diagnosed. I then took Folgard, Lovenox, over the counter prenatal, calcium, fish oil, and Juice Plus and had a wonderful pregnancy without complications. Our daughter is very healthy.

    After having her I was diagnosed with a thyroid goiter, had it half my thyroid removed and it the large goiter was benign but they did find a very small growth of papillary cancer. (maybe due to excess folic acid levels?)

    So now we are planning to get pregnant again. The above supplement list is very extensive (not to mention expensive) and not sure about the quantities on this list. Ultimately I want to know what I should take. I know how you feel about Folgard and was looking at changing to Metanx, but also thinking I should just stick to this list and not take a perception supplement or the Juice Plus. How do you feel about Juice Plus?

    Thank you for your advise and information.

    • Dr Ben May 21, 2012 at 5:55 am # Reply

      Leslie –

      I am not sure about Juice Plus. It may be good as a supplement – but is definitely not the only thing you should be taking.

      A supplement containing L-5-MTHF is as good as a drug containing L-5-MTHF as both are Metafolin. I am not fond of any prescription drug with L-5-MTHF (methylfolate) as all drugs contain fillers, flow agents, colors, etc.

      You are right – Folgard is not the best.

      I am glad that you carried to term for your previous pregnancy – that’s awesome :) I do caution you with folic acid and I am glad you are aware of that as well now.

      Methylfolate as L-5-MTHF (metafolin), methylcobalamin and vitamin B6 are truly needed for those with MTHFR mutations.

      Folinic acid is also useful – which is found in leafy greens – and some supplements.

      • Angela July 8, 2012 at 10:57 pm # Reply

        Hi Dr Ben – what is your opinion of people with Histadelia as this appears to be linked to the MTHFR in regards to not being able to methylate properly both Folate and B12.

        • Dr Ben July 12, 2012 at 12:12 am # Reply

          Angela –

          Absolutely linked – no question in my mind at all.

  12. Angela Perez July 12, 2012 at 4:55 pm # Reply

    Hi Dr. Ben,

    I have some questions. I was recently pregnant and lost the pregnancy at 9 weeks. I found out 2 weeks prior that I had MTHFR one of the C677T mutation and one of the A1298C. I am 42 years old.I have one son who is 13 years old and that pregnancy was fine. I did not know about the MTHFR.
    We are wanting to TTC again soon.
    My Dr. has me taking this: NeevoDHA, 1MG of folic acid, 1 81mg asprin, and 1 D3 1000iu.
    My question is I want to switch the folic acid I am taking now to the correct kind. I am going to order the L-5-MTHF 1000 that you recommend here. I wanted to know how much you thought I should be taking in addtion to the NeevoDHA?
    Also, I was thinking about the Chewable Optimal Multivitamin but wanted to double check that it’s ok to take with the NeevoDHA? I had thought that the Neevo and all I needed but after looking at your site I am thinking it doesn’t.
    I am looking for a new OBGYN although I love mine, I need one that knows a bit more about MTHFR. Mine did tell me he would put me on Lovenox if I get pregnant.
    Any advise would be appreciated!!

  13. Jourdan July 12, 2012 at 5:50 pm # Reply

    Can you clarify your thought about lovonox. I think my Peri basically prescribed it as a safety measure. Will your supplement protocol negate the need for lovonox? I’m also on folgard but headed to health food store right now to get the items you suggest instead.

  14. Jennifer July 18, 2012 at 9:58 pm # Reply

    Hi Dr. Ben,

    Thank you for these recomendations for pre-natal supplements. Can you provide recommendations for proper supplementation prior to conception? (with the hopes of conceiving sometime in the near future?) I have a single copy of C677T and am hoping to conceive again soon – we have had 4 miscarriages in the last 4 years (and one healthy baby during that time as well). Thanks – I’d really appreciate knowing what to be taking now, before pregnancy.

    • Dr Ben July 25, 2012 at 7:31 am # Reply

      Hi Jennifer –

      I would take the above to prepare yourself prior to getting pregnant – and then maintaining it. Finding a great prenatal right now is also recommended.

      • Jennifer July 26, 2012 at 2:35 am # Reply

        Thanks Dr. Ben – I have looked at the different prenatals you recommend, and as you mention for your first two choices, I do have a hard time with iron, so I took a look at the kids’ optimal multivitamin. Typically, I also have a hard time swallowing pills during pregnancy, and 6 a day sounds like a lot. I was looking at your chewable multivitamin, but noticed you do not include that on your prenatal recomendations list – is there a reason this should not be used as a prenatal?
        Thanks again,

        • Dr Ben July 26, 2012 at 4:19 am # Reply

          Hi Jennifer –

          The chewable multivitamin is a good alternative – good point. I want you to make sure you are getting enough methylfolate from other supplements though – such as Active B12 with Metafolin or the L-5-MTHF.
          I will update my list to include it.

          The Kid’s Optimal Multivitamin uses quite small capsules – much smaller than the average multivitamin so that is one bonus ;)

          Make sure you take any multivitamin with meals.

          In health,
          Dr Ben

          • Jennifer July 27, 2012 at 6:13 pm #

            Dr. Ben,

            I just looked more carefully at the chewable vitamin ingredients, and am wondering if perhaps it may not be as good a choice as the others, as it contains licorice extract, which according to some herbal sites is contra-indicated for pregnancy. I’m not sure how you feel about the use of herbs during pregnancy though.

  15. Erin July 24, 2012 at 2:05 am # Reply

    My husband and I have been trying to conceive for the past 5 years (no babies yet). We have had 3 miscarriages in the past 12 months all different but all were lost under 11 weeks. I just started to see a RE this month and he had me do a lot of blood work. Out of that I found out that I am compound heterozygous (1 copy of 677CT + 1 copy of 1298AC). My homocysteine level is 8.6

    My RE put me on NEEVO DHA per my request to try to get the active folate (started 3 days ago) plus 3mg of Folic Acid (have not started due to my concern over synthetic and not active folate). After listening to your podcast it seems as though I should be taking all of your suggestions from Active CoQH down to the Optimal Fish Oil.

    My question right now is do I also continue to take the NEEVO DHA along with all of this or would I stop the NEEVO DHA and only take your #1-9. Also I am not currently pregnant we are trying to conceive so would the amounts of what I should take change?

    Do you have thoughts on taking a baby Asprin and progesterone (after ovulation) daily trying to conceive and throughout a pregnancy? My RE also recommended that too.

    Any information would be greatly appreciated.

    • Dr Ben July 25, 2012 at 6:27 am # Reply

      Hi Erin –

      I am not a fan of synthetic folic acid at all. It is an archaic recommendation that is fraught with issues. Standard medicine highly recommends it to this day and will likely continue to do so for another 10 yrs sadly. There is so much data pointing to the risks of excessive folic acid yet nothing is done about it.

      Neevo DHA is a useful basic and incomplete prenatal – however – it does have its place and I am glad doctors are using something.

      I am very oriented towards prevention so my recommendations are more likely ‘overkill’ to some docs and midwives; however, if you think about it, as future parents, it is our responsibility to provide the healthiest DNA and environment as possible for our developing children – and our future grandchildren. So – in short – yes – I recommend #1 – #9. This is not a long term thing where you have to take all this forever – but it is designed to optimize your health and your babies health as much as possible.

      I personally wish i knew 1/20th of what I know now before my wife and I had our three boys. Thankfully our boys are healthy but I wonder how much better off they would be if we had optimized our health.

      If your progesterone levels are low or low normal, taking more progesterone is likely needed. Taking a baby aspirin is also a good idea.

      I am passionate about this area of medicine and am happy to discuss with you more in depth about how to optimize your health for pregnancy. There is a lot more to it than what is in this article above and during a consult, I can help direct you better should you need it. Please call 800-547-9812 should you want to schedule a consult or you may RSVP online as well here.

      • Erin July 25, 2012 at 7:20 am # Reply

        Thank you Dr Ben for your quick response. I was actually reading more information on your site when you left your response haha. I so appreciate all the information you have made available regarding MTHFR. Thank you!

        I so appreciate all of your feedback and I will be talking with my husband to see if I can make a consult apt with you.

        In the meantime if I understand correctly I should continue taking NEEVO DHA plus your #1 – #9 correct?

        If my RE wants me on 4 mg of folic acid (total) would it be safe and normal for me to take 4 mg of the active folate (total) instead? Harm in taking too much active folate?

        Being that I am Compound Heterozygous as well would it be a good idea for me to be on Asprin 81mg daily (for the rest of my life or just while trying to conceive after ovulation and during pregnancy)?

        Thanks in advance!

      • Angela July 25, 2012 at 8:23 am # Reply

        Dear Dr Ben. I am a nutritional therapist in the UK and thanks to your site I am now recommending that a lot of my clients who are having multiple miscarriages go for the MTHFR test. I have really good links with the Nutricentre in London, one of the best supplement company in the UK. I will have a word with them about stocking your products. I have also spoken to a company I use ‘vital greens’ who have formulated a wholefood supplement to look at replacing folic acid and cynocobalamin in their products with active methyl folate and methyl cobalamin. It turns out their nutritional therapist in their London office has just tested MTHFR C677, so it might sway them more! What I wanted to know is do you send internationally, if I send a few clients your way for the supplements? Thanks in advance so much for all your fab information. Also have you thought about practitioner podcasts, this information is so vital! Best wishes Angela.

        • Dr Ben July 26, 2012 at 5:59 am # Reply

          Angela –

          Thank you for your kind words and support. Much appreciated ;)

          I am glad you are recommending the MTHFR test – excellent to hear!

          My company, Seeking Health, does ship worldwide – absolutely. We use FedEx International and also the USPS International services. I thank you for any and all referrals – they are very much appreciated. Seeking Health is what allows me to continue my research – so without Seeking Health, my time to research would be seriously limited.

          Thank you for talking with Nutracentre in London. That is excellent!

          Practitioner podcasts – I would love to do that and have plans on doing so – just a question of getting organized and time.

          How would you like the practitioner podcasts to be? What are your thoughts? Format?

          Dr Ben

      • Angela November 10, 2012 at 1:25 am # Reply

        Hi Dr. Ben!

        Thank you so much for all of this useful information! It is a lot to digest but thanks to you I am understanding this gene mutation a little bit better (compound hetero. MTHFR – Homocysteine Level at 6.9). I am 5 weeks pregnant and started with some of your recommendations several months ago. I too am on a budget so I am currently taking your Optimal Chewable Vitamin, Calcium Mag. D3, and Sublingual B12 with Folate.

        I had my first prenatal appointment today and shared my information with my OBGYN and she didn’t know anything about MTHFR and she didn’t think that I was taking enough Folic Acid…with your Chewable Multi and the Sublingual B12 I am taking 1200mcg. She wants me to take a standard Folic Acid in the amount of 4g. I didn’t want to argue with her but I tried to explain everything that I have learned on your website. She said that she would feel better if I were to take the 4g in addition to what I am taking and the extra amount wouldn’t do any harm.

        I refuse to take the synthetic folic acid after what I have learned from your site. Instead, I just ordered your L-5-MTHF supplement. Would I then take 4g of the L-5-MTHF? Please let me know what you believe is the best dosage.

        I really wish that I could listen to your podcast but I have a slow internet connection. Is your podcast in an article form?

        Thank you again for your concern and dedication to MTHFR!


        • Dr Ben November 10, 2012 at 7:42 pm # Reply

          Angela –

          The multivitamin I really like for pregnant women is by Xymogen – Prenatal Essentials.
          Please switch to that from the chewable Optimal Multivitamin – ideally ;)

          The best thing to do is to evaluate your current methylation status and optimize your nutrients based on that.

          If that is not possible due to budget, then you need to assess how you are feeling and follow your doctor’s recommendations – or find a doctor that you feel is more knowledgeable in this area.

          If you feel good taking what you are doing, then you may try increasing the amount of b12 and methylfolate. If you still feel good on a higher amount, you may maintain that. If you feel badly or experience symptoms, then you need to reduce the amount. Of course, listen to your doctor and find one that is knowledgeable in methylation.

          Folic acid is synthetic and hard for you to process it due to MTHFR. If you take the b12, methylfolate and folinic acid – which is found in the Prenatal Essentials – then you providing your body and baby key nutrients for methylation.

          If your OB doesnt know anything about MTHFR, then the recommendation of taking 4 mg of folic acid makes sense because of the lack of knowledge.
          4 mg of folic acid is the standard protocol for those with recurrent miscarriages yet it not appropriate for all situations; and, in my opinion, not recommended due to new knowledge of how prevalent MTHFR mutations are.

          My podcast is not in article form – apologies. I am writing a book now on MTHFR – slogging through it :) but I will get it done.

          Excess folic acid can do harm – there is research showing that excessive folic acid can do harm. But of course – so can not enough folate.

          Remember to maintain your nutrients during breastfeeding.

          Please understand that the information provided is simply that – how you apply it is at your own risk.

          • Angela November 10, 2012 at 11:18 pm #

            Hi Dr. Ben!

            Thank you for the quick response. That prenatal looks fantastic accept for the fact that it is high in iron and I have difficulty with iron. I actually took a prenatal with my last pregnancy that didn’t contain any iron.

            I feel good taking the optimal chewable, active b12, and calcium mag. D3. So far it has been agreeing with me and I have been taking it since August. I only take 1 tablet of the Active B12 daily. I am uneducated when it comes to vitamins and their daily values. I ordered your L-5-MTHF to try and add a little bit of that at a time instead of more of the Active B12 due to my concern that I would be taking too much B12. In your opinion, which is better for me to add a little bit more of…the Active B12 or the L-5-MTHF?

            Thanks so Much!


            P.S. – My father also has MTHFR and I have told him to switch from the synthetic Folic Acid to your Active B12 and he loves it!!!

  16. Jordan July 25, 2012 at 4:20 pm # Reply

    I am 18 weeks pregnant and a few weeks ago my doctor called me saying that I have mthfr. She put me on a different prenatal with more folic acid. Everything that I read about says that I should be doing more. Does this mean I don’t have it as bad or something? Or should I be questioning my doctor?

  17. Katie July 25, 2012 at 9:01 pm # Reply

    I was diagnosed Compound Heterozygous after I lost my son at 20 weeks. Unfortunately, my doctor convinced me the MTHFR mutation was a non-issue (both for my son’s death as well as any future pregnancies). I went on to lose another baby at 7 weeks shortly thereafter. I have since switched to a high-risk OB who takes MTHFR mutations seriously, treating with baby aspirin and eventually Lovenox when I become pregnant again. However, he is not very knowledgeable about B vitamins. So, I have some questions for you:
    Should I continue to take the Optimal Fish Oil while on baby aspirin Lovenox? If so, how much?
    Do I need to take both the Sublingual Active B12 with Methyfolate AND L-5-MTHF? How much of each?
    If I took the Chewable Optimal Multivitamin, would the Sublingual Active B12 with Methyfolate cover my B Vitamin needs?
    I am taking D3 for a deficiency at 5000 I.U. (Country Life). Does this cover my D3 needs?
    I am taking Barlean’s Fish Oil EPA/DHA. How can I tell if it is in the triglyceride form?
    My current prenatal has been Nature’s Plus, Source of Life Prenatal Liquid, as I have thrown up every single other multivitamin I have ever tried. This one seems to be gentle on my stomach and cover a lot of the basic vitamins and minerals and being based in whole foods. I’m not sure if it’s because of the liquid form (I seem to tolerate liquid and chewable vitamins much better) or it’s whole food base (which I’m sure can’t hurt!) Have you ever taken a look at it? If not, are there any whole food prenatal multivitamins that you would recommend (preferably available in either chewable, liquid, or capsule form)?
    Thank you so much.

    • Dr Ben July 26, 2012 at 5:53 am # Reply

      Hi Katie –

      If you are taking the Barlean’s Fish Oil, then I would not add the Optimal Fish Oil. You may switch out the Barlean’s fish oil and then take the Optimal Fish Oil. You will have to ask your OB if you can take your fish oil along with Lovenox and baby aspirin. I would think your doctor would adjust your dose of Lovenox and baby aspirin so you could take your fish oil. It is important you take EPA/DHA while pregnant.

      You have to put a call into Barleans to see if their fish oil is triglyceride form.

      5,000 IU for vitamin D3 is pretty good. Measure your vitamin D3 levels to be sure your levels are good.

      Consider taking the Sublingual Active B12 with Metafolin first without the L-5-MTHF on its own. If your doctor wants you taking more methylfolate, then you will have to take L-5-MTHF in addition to the Sublingual Active B12 with Metafolin.

      If your prenatal contains folic acid and not any methylfolate, then I would veer away from it and use one that does. If your prenatal has both methylfolate and folinic acid, that is fine.

      I do not know of any liquid prenatal vitamins that are any good nor do I know of any that are chewable. The ones I recommend above are the ones I recommend via capsule or chewable.

      If you took the sublingual and the chewable multivitamin, that may cover your B vitamin needs – it depends on your labs, symptoms, history and what your doctor recommends you.

      • Deanna July 31, 2012 at 1:25 am # Reply

        Hello Dr. Ben,
        I was recently diagnosed with MTHFR, one of the C677T mutation and one of the A1298C. I found out at 10 weeks (which was too late) and then ended up finding out that the baby had severe NTD’s along with not completely developing. It was fatal but I did not miscarry, instead my doctor asked that I have a D&E. I have a perfectly smart and healthy 2 year old daughter and am completely confused on how this happened. We are currently trying to conceive again (two-three months after our loss) and my doctor has prescribed me Neevo DHA, 4mgs of folic acid, 50mcgs of B12, and 50mcgs of B6. I recommended the Neevo but I do not understand the folic acid. I also cannot find B12 and B6 that low in dosage. Is there anything I could supplement for the folic acid and B6 and B12? Also, since I didn’t actually miscarry, do you recommend that I take baby aspirin still? Thanks for your time.

  18. Angela Perez July 28, 2012 at 2:42 pm # Reply

    Hi Dr. Ben,

    I have some questions. I was recently pregnant and lost the pregnancy at 9 weeks. I found out 2 weeks prior that I had MTHFR one of the C677T mutation and one of the A1298C. I am 42 years old.I have one son who is 13 years old and that pregnancy was fine. I did not know about the MTHFR.
    We are wanting to TTC again soon.
    My Dr. has me taking this: NeevoDHA, 1MG of folic acid, 1 81mg asprin, and 1 D3 1000iu.
    My question is I want to switch the folic acid I am taking now to the correct kind. I am going to order the L-5-MTHF 1000 that you recommend here. I wanted to know how much you thought I should be taking in addtion to the NeevoDHA?
    Also, I was thinking about the Chewable Optimal Multivitamin but wanted to double check that it’s ok to take with the NeevoDHA? I had thought that the Neevo and all I needed but after looking at your site I am thinking it doesn’t.
    I am looking for a new OBGYN although I love mine, I need one that knows a bit more about MTHFR. Mine did tell me he would put me on Lovenox if I get pregnant.
    Any advise would be appreciated!!

  19. Lacy August 3, 2012 at 2:06 am # Reply

    I just found out i am heterozygous MTHFR 1298C after my 4th miscarriage. I also am heterozygous for factor 5 leiden. I have a healthy 5 yr old but after that pregnancy I have had 4 pregnancy losses. With the pregnancies I have done lovenox injections because of the factor 5 leiden. We are now trying to get pregnant again. I am taking 2mg of folic acid (OTC), is that what I should be taking or does it need to methylfolate?? I am also taking vit b6 and b12 to help with absorption. Any other meds my doctor should consider??

    • Dr Ben August 5, 2012 at 7:22 am # Reply

      Hi Lacy –

      There are many factors at play here and all need to be carefully evaluated for increasing the likelihood of a positive outcome and healthy child.

      I do recommend everything mentioned in the article here for those who are pregnant. I also recommend that the father/husband/partner supplement properly as well in order to provide healthy epigenetics to your developing child.

      I also think that baby aspirin in addition to Lovenox may be useful. You will have to talk with your hematologist and/or OB/GYN about this.

      • Lacy August 5, 2012 at 6:23 pm # Reply

        I did just order new prenatal vitamins with folinic acid and the metafolin to take instead of the OTC folic acid. I have been taking baby ASA when we are in the trying process and then switch over to the lovenox once I have a positive pg test. Do you think that by taking these meds that it would cover my bases or are there other ones you would recommend?

  20. Aleina August 5, 2012 at 2:14 am # Reply

    Is there a reccomendation for how much methylfolate to take when you have had a prior pregnancy with a NTD? My doctor had me on 4mg folic acid during my last pregnancy, which seemed to work (had a healthy baby), but I definitely want to stay away from that next time around and stick to methylfolate. But I’m nervous! I haven’t been able to take more than 1mg without side effects and I’m worried that won’t be enough. I know that it’s better absorbed than the folic acid, and my rational brain understands that less should be fine, but I definitely don’t want to deal with another NTD. Just curious if you have any thoughts!

    • Aleina August 5, 2012 at 2:15 am # Reply

      Oh and I am compound hetero if that makes a difference.

    • Dr Ben August 5, 2012 at 7:03 am # Reply

      Hi Aleina –

      4 mg is the standard recommendation during pregnancy for past miscarriages and past NTD; however, that is using standard folic acid – not methylfolate and folinic acid.

      I do not know – nor does anyone – how much methylfolate and folinic acid to use during pregnancy for those having past NTD.

      I believe if you could take 3 mg of folinic acid and 1 mg of methylfolate, that may be a good combination for you. The goal here for me is to limit the amount of unmetabolized folic acid circulating in your system.

      If you get side effects, then maybe you do not as much as you did prior.

      The prior pregnancy with NTD – were you recently taking birth control pills or not supplementing with adequate nutrients prior to pregnancy? Digestive disorders?

      You may also test many different types of folate forms by taking this methylation test – I think this along with the unmetabolized folic acid test would be very useful tool in combination.

      Your doctor will likely not know how to interpret either test - I am available via consults to help you should you decide to order them.

      These are all questions that must be evaluated.

      • Aleina August 5, 2012 at 3:47 pm # Reply

        Thank you for your reply.

        I just remembered that I did take some folinic acid during my last pregnancy, along with the folic acid. I didn’t realize folinic and methylfolate were different, that’s good to know.

        I had been on hormonal birth control (nuvaring) just before getting pregnant. Definitely wasn’t supplementing before pregnancy (wasn’t planning to get pregnant) and have had some digestive issues my whole life. Plus my diet was not the greatest then (a lot better now!).

        I’ll look into those tests, thank you!

      • Erin August 7, 2012 at 12:20 am # Reply

        Hi Dr Ben!

        So you recommend 3 mg of folinic acid and 1 mg of methylfolate? I thought the idea was to get more methylfolate if you don’t absorb folic acid. I am compound hetero as well trying to conceive after 3 miscarriages and I was trying to work up to like 3.4 mg of methylfolate as I thought that was the best form of active folate to take. I wasn’t even considering folinic acid. I feel like I haven’t even seen any info on that. Would you mind explaining more as I want to make sure Im taking the right vitamins.

        Thank you!

      • Aleina August 20, 2012 at 10:59 pm # Reply

        Hi again,

        Just wanted to update that since I started taking the methylfolate with methyl b12, I haven’t had any side effects. I’m up to 1mg in my prenatal, 1mg on it’s own, and 2 sublingual active b12’s a day and feeling great. Not sure if I’m pregnant yet, but feeling a lot more confident that if I am, I’m well supplemented. :)

        Thanks again!

  21. Stephanie August 18, 2012 at 6:40 pm # Reply

    I found out my 12 week baby had anencephaly and I had to terminate the pregnancy. I was diagnosed with homozygous c677t and negative for the other. My doctor tested my homocysteine levels – they came back at 5- and then
    put me on Folgard 2x a day
    After doing my own research I saw Folgaurd probably wasn’t going to be enough. I too scared to stop taking it altogether so now I take:
    1 Folgaurd, 5 mg Thorne 5-mthf, Neevo DHA, vit D, fish oil, and a liquid B complex. Anything you would add/take away? I can’t go through this again and am ready to ttc again but want to make sure my body is ready.
    Thanks so much for all you do here!

    • Lynn_M August 22, 2012 at 6:36 am # Reply

      Drop the folgard and maybe the liquid B complex. You don’t want to take anything that has folic acid and cyanocobalamin in it. They competitively inhibit the forms you need, L-5-MTHF and methylcobalamin. You can add B6 and methylcobalamin as separate supplements, or Dr. Ben sells a combo product. You might do better taking the active P5P form of B6.

      A homocysteine level of 5 seems low. Ideal is 6.3.

  22. Tania Diogo August 30, 2012 at 6:33 pm # Reply

    I try to eat a whole food real food diet and have not been taking a prenatal b/c I could not find one with ‘real’ (not synthetic) vitamins. I am 24 wks pg with #2. I do take Fermented Cod Liver Oil. I suspect we have MTHFR (lots of tongue ties etc in our family includig my 11 m old). What do you think of a prenatal such as

    They ship to Canada, but I noticed that it has ‘folate’ is this the same as folic acid? I don’t want to take any form of folic acid aside from the ones recommended for MTHFR.

    • Lynn_M August 31, 2012 at 2:54 am # Reply

      I had your same concern regarding a different supplement. It was a whole-foods based non-synthetic liquid supplement which supposedly provided every nutrient needed by our bodies. The ingredient listed folate and I wasn’t sure if that meant MTHF or not. So I did some researching about the forms of folate found in vegetables and fruits.

      I think it’s very unlikely the folate in your product is folic acid. However, based on the prevalence of various folate forms in vegetables and fruits, the folate is probably one of the intermediary forms found inbetween folic acid and MTHF in the folate cycle. There might be some MTHF in there, but I wouldn’t count on there being much. You probably would be wise to additionally supplement with MTHF.

      • Tania August 31, 2012 at 4:47 pm # Reply

        Thanks Lynn. The reason I am concerned is b/c I read that people with MTHFR should NOT ingest any sort of synthetic folic acid as this can interfere with the bodies absorption of ‘real’ folate. I do plan on taking an additional supplement of MTHF, as well.

  23. Lena August 31, 2012 at 4:39 pm # Reply

    hi Dr. Ben,

    I am 6 weeks pregnant, naturally conceived, after 2 years of infertility. I found out at 5 weeks pregnant that I have homozygous A1298C mutation and have been taking b-vitamins, 5-MTFH and baby aspirin since finding out my diagnosis.

    I am terrified because I was not taking the proper supplements until 5 weeks into my pregnancy, my pre-natals only contain 600mg of folate. I am scared not only of miscarriage but even more so, down syndrome and NTD.

    I’d appreciate any insights.

  24. Jennifer September 3, 2012 at 6:17 pm # Reply

    Hi Dr. Ben,

    In my quest to find a good prenatal vitamin, I made an inquiry to Designs for Health, after seeing it listed on one of your posts. I asked specifically what type of methylfolate they used (they call their folate blend “NatureFolate”, which I thought I had read somewhere on here that it was not a good type). This is the response I received from them:

    “NatureFolate is a blend of the natural S-form of both 5-Methyl and 5-Formyl tetrahydofolate. The amounts of each is proprietary information. ”

    Would you consider this to be an acceptable form of methylfolate for a heterozygous C677T person like myself?

    Thank you for your advice,

  25. Summer Bonnet September 12, 2012 at 12:18 pm # Reply

    Hi Dr Ben,

    I had a consult with you a about two months ago. I am MTHFR – C677T, heterozygous. I have had three miscarriages, I was told these should not have happened due to my mutation as my homocysteine level is within normal range – from memory 9. I am following your advice, my obstetrician and naturopath – I would like someone as educated as you on mthfr around the corner from me, but sadly there is not.

    As I have started to try an conceive I was hoping you could double check the supplements I am taking: (some are not your vit’s, I purchased them prior reading the info on your site, others are recommended by my naturopath)

    L-5-MTHF 1000 – SeekingHealth – 1 per day (at lunch with food) – should this be changed to two per day?
    Folinic Acid 384ug – Pureinnovation – 2 per day (one am & one pm with food) – should this be changed to one per day?
    Sublingual Active B12 – SeekingHealth – 1 per day (am with food)
    MultiBiocomplex Multi Vit – Nutri medicine – 1 per day (lunch with food)
    Permular Extract of Vitex agnus-castus – 1 per day (am one hr before food)
    Lavandula Compound – Nutri medicine – 2 per day (am with food)
    Active CoQH – SeekingHealth – 1 per day (Lunch with food)
    Omega3 40:20 – Nutri medicine – 2 per day (two am & two pm with food)
    Mag300 biocomplex – Nutri medicine – 1 teaspoon (mid morning after food)
    Optimal VitE – SeekingHealth – 1 per day (am with food)
    Redsuperkrill – goodhealth – 1 per day (lunch with food) wanted to purchase yours, has the extra astaxanthin but it could not be shipped internationally.

    I also take Niacin now and then – a quarter of a 100mg tablet – I am not sure how to use the niacin.. I know it soaks up too much methylation.. I am just not sure how much methylation I need. Is too much methylation bad for you in health terms? I don’t want the niacin to take away the good that I am putting in (I also make a green smoothy as part of breakfast, juice greens about every second day ect)

    You also mentioned some tests I should get done in the consult, (I thought the consult was getting taped), I did scribble these down, but I have lost my note book… sorry for the trouble.. but are you advise these again?
    Lets hope I am doing everything I can.

    Kind regards
    Summer (alias)

    • Lynn_M September 12, 2012 at 10:44 pm # Reply


      I would not take anything sublingual, such as the active B12, with food. Food inhibits absorption.

      • Summer Bonnet September 13, 2012 at 7:41 am # Reply

        Thanks Lynn, I will make that adjustment. So one hour before or after food would be ok?

        Are you also able to comment on the folinic acid and L-5-MTHF 1000, plus the other Q’s? I’m hoping I get a positive test in about three days time x

        • Lynn_M September 13, 2012 at 2:49 pm # Reply

          Yes, one hour before or after food is okay on Vit B12. The other thing to consider is you don’t want to take Vit B12 within 45 minutes of taking Vitamin C, otherwise the Vit C inactivates the B12..

          Regarding how much folinic acid and L-5MTHF to take. Dosing is so individual, it’s hard to say. When you want to change dosing of something, I would change one substance at a time and give it at least a few days to see if you feel any impact. Personally, I would take more L-5MTHF than folinic acid.

          I muscle test everything I take, and my body doesn’t necessarily want the same substances in the same doses every day.I found some chiropractic research that supposedly affirmed the validity of muscle testing, but I could only access the abstracts. I do the sway test when testing myself, and I also have a health practitioner that double-blind tests supplements and foods for me using a different technique. I don’t know if doctors other than chiropractors think muscle testing has any value.

          As it gets metabolized, niacin eats up the methyl groups that you’re trying to increase. I wouldn’t take it unless you have symptoms of overmethylation (irritation & anxiety). You’re probably getting your sufficient RDA of niacin in your green smoothies and juices.

          And remember that treating MTHFR is far more than just taking supplements. Avoiding toxicity, both from external agents and from what we generate internally when we’re in fear and anxiety, relieves the body of the need to detox, and spares the B vitamins for body-building rather than detoxing.

          • Summer Bonnet September 17, 2012 at 10:11 am #

            Hi Lynn,

            Thank you for your reply. Working out what my body needs is the problem, finding a health professional close to me who is an expert in this field is also a problem.

            I have always experienced, I think mild, symptoms of anxiety (maybe they are not so mild for the average person). So I am finding it difficult to work out how much L-5MTHF and folinic acid to take – I am not sure if it’s the vits making me anxious and irritable – or if I’m just trying to deal with too much and pushing on. I think instead of taking two L-5MTHF and one folinic acid (which I was thinking of changing too above), I will take one L-5mthf in the morning and one folinic acid at night, plus eat or drink lots of leafy greens. As I am wanting to have a child, and due to the MTHFR – C677T, plus three miscarriages, I feel the risk of overmethylation is better than undermethylation… ? .. I hope.

            Anyway, thank you for providing this information (there are still health professionals out there who are prescribing just folic acid – or disregarding completely), between work and study I will educate myself more, plus start relaxation techniques. I will be due to order some vitamins soon.

            Kind regards

  26. Andrea September 17, 2012 at 2:46 pm # Reply

    Hi Dr beneficios I amor heterozygous for the C677T if I had todo choose one suplement for now which one do you recommend? I think it will be the optimal multivatamin what do you think.

    • Dr Ben September 17, 2012 at 8:34 pm # Reply

      Hi Andrea –

      Without a history, that is tough for me to state; however, if you are looking for general support and are not sensitive to supplements, yes, Optimal Multivitamin would be a good start.

      • Andrea September 23, 2012 at 12:50 am # Reply

        Hi Dr.Ben this is my history,in 2001 I lost a baby at 12 weeks Dr told me it was normal,in 2003 my son was born without complications it was a natural delivery,last year after 8 years of having mi first born I decided to get pregnant again didn’t have any problems with that but at week 13 started spotting and by week 18 started heavy bleeding plus blood clots Doctors told me I had placental abruption,I also had a urinary infection that never went away,two days before week 23 I lost almost all amniotic fluid and at week 23 baby was stillborn:( the pathology of the placenta came out normal,so confuse about that.Anyway months later went for testing and this is what I have. MTHFR one copy of the C677T. I am 29 years old. THANKS

        • Andrea September 23, 2012 at 12:55 am # Reply

          Forgot to say I really would like to try to conceive soon,right now I am taking B rigth complex and folate as L methylfolate as metafolin 800 mcg.thanks an so sorry really trying hard with mi English.

          • Andrea September 23, 2012 at 6:06 pm #

            Also I am thinking on taking the Thorne basic prenatal but have questions about the vitamin k in it,because I am taking aspirin and plan to do the heparin during pregnancy.

  27. Amy R September 22, 2012 at 5:05 am # Reply

    Dr Ben,
    I have been taking your optimal multivitamin capsules for a couple of months now. I recently found out I am expecting. I am compound heterozygous for MTHFR and will try to follow the above guidelines. One question though, I don’t see the optimal Multivitamin capsules listed as one of the multivitamin options above. Is there a reason for me to switch to a different multi while pregnant? Also, I saw another post asking about licorice in the chewable multivitamin from seeking health being contra indicated for pregnancy but didn’t see your reply. Is that something to be concerned about with the chewable?
    Thanks so much for your knowledge and help!

    • Dr Ben September 24, 2012 at 9:14 pm # Reply

      Hi Amy –

      Congratulations :)

      I would like to see you take something like Xymogen’s Prenatal or Thorne’s Prenatal.

      The licorice is not a good idea to take while pregnant. The tiny amount found in the chewable is likely fine but due to the sensitive nature of pregnancy, I would like you and others to avoid it.

      • Andrea September 27, 2012 at 6:23 pm # Reply

        Hi Dr.Ben this is my history,in 2001 I lost a baby at 12 weeks Dr told me it was normal,in 2003 my son was born without complications it was a natural delivery,last year after 8 years of having mi first born I decided to get pregnant again didn’t have any problems with that but at week 13 started spotting and by week 18 started heavy bleeding plus blood clots Doctors told me I had placental abruption,I also had a urinary infection that never went away,two days before week 23 I lost almost all amniotic fluid and at week 23 baby was stillborn:( the pathology of the placenta came out normal,so confuse about that.Anyway months later went for testing and this is what I have. MTHFR one copy of the C677T. I am 29 years old. THANKS

        Andrea September 23, 2012 at 12:55 am # Reply
        Forgot to say I really would like to try to conceive soon,right now I am taking B rigth complex and folate as L methylfolate as metafolin 800 mcg.thanks an so sorry really trying hard with mi English.

        Andrea September 23, 2012 at 6:06 pm #
        Also I am thinking on taking the Thorne basic prenatal but have questions about the vitamin k in it,because I am taking aspirin and plan to do the heparin during pregnancy.

      • Amy R February 8, 2013 at 1:12 am # Reply

        Dr Ben,
        I lost the baby I mentioned above and then another one a few wks ago. So two miscarriages this time so far (I had three before my now 3 year old was born).
        I was on heparin, low dose aspirin, Thorne prenatal, MTHFR supplements (L5 MTHF and the B12 lozenge) for both of my recent miscarriages. My question is this, when I get 1 mg folate from Thorne, 1 mg from L5 MTHF and 800 mcg from Active B12 I am unable to sleep at night. If I cut out the active b12 lozenge I sleep fine. I’m worried though with cutting it out and only taking 2 mg of folate given my miscarriage history, my compound heterozygous MTHFR for both C and A and my factor V Leiden. Am I getting enough folate since over 2 mg seems to give me adverse side effects? Especially concerned after now having two more miscarriages even with treatment. With my successful pregnancy I was actually on Folgard.
        My MD is telling me we will start prednisone with the next pregnancy to see if that helps. I saw on the MTHFR protocol in pregnancy on this site that the MD that responded to the women’s questions had a steroid listed. Is a steroid ok to take?Any additional supplements I should take if I’m on a steroid with the next pregnancy?
        Thank you so much!

  28. Melissa October 1, 2012 at 6:56 am # Reply

    This is very helpful. I’m so thankful I found this website. Thank you! My question is if I take the Thorne Prenatal, do I really need ALL the other supplementations listed? The Thorne Prenatal has 1mg of folate already. I am heterozygos for the C677T mutation and I don’t want to take too much methylfolate. Is the 1 mg in the Thorne prenatal enough for me or do I also need the Sublingual Active B12 with Methylfolate, and the L-5-MTHFR supplements you recommend as well?
    My history- My first pregnancy in 2009 resulted in severe IUGR and preterm labor at 35 weeks (she was only 3 lbs, 11 oz). She is otherwise fine, but still very small for her age. For my second pregnancy I was treated with Lovenox, baby aspirin, and Folgard due to my pregnancy history. At that time I didn’t have any blood tests done but my IVF doctor treated me with his “implantation failure” protocol (Lovenox, BA, Folgard) due to the IUGR in my first pregnancy. Unfortunately, I lost the baby at 18 weeks. I was shocked that I miscarried because I thought the Lovenox and BA would help, not make the outcome worse! After reading your website, I think maybe the key is to not take the Folgard and supplement with what you suggest. After my miscarriage, I had a million blood tests done and the only thing that came back positive for me was the one copy of the C677T mutation. Everything else was completely normal. I was told that the one copy “means nothing to my healh” especially since my homocystine levels were normal. Thanks to your website, I am learning that is not true. My husband and I deperately want to have another baby and we are getting ready to try another round of IVF. However, I am scared to death since I already “failed” being on the Lovenox, BA, Folgard protocol. Any help or suggestions would be greatly appreciated! Thanks for your time.

    • Melissa October 2, 2012 at 5:29 am # Reply

      Are all the supplements you list here safe to take while going through an IVF cycle? In other words will any of the supplements interfere negatively with the IVF drugs (i.e. estrogen, progesterone) that one needs to be on when getting the body ready for implantation?

  29. Erin October 11, 2012 at 4:23 pm # Reply

    Hi Dr. Ben, Thank you so much for all of this information on MTHFR and prenatal supplements. It has been extremely helpful! I have PCOS and have had amenorrhea for several years. I used Clomid in 2010 in order to get pregnant with my first baby. Now, trying to have my second baby, I went dairy- and gluten-free earlier this year in hopes of bringing my cycle back. I also returned to the fertility center and it is standard practice for them now to do genetic testing. I recently found out that I am compound heterozygous MTHFR. I am trying to determine how much methylfolate, folinic acid, and methylcobalamin I should take daily before and during pregnancy. My midwife is not knowledgeable about MTHFR and does not have a recommended dosage for me. I am planning to take many of the supplements you recommend, including Thorne Basic Prenatal and Seeking Health Active B12 with Methylfolate Lozenge (2 per day). If I do that, I will have 2100 mcg of methylfolate, 500 mcg of folinic acid, and 2000 mcg of methylcobalamin per day. Is that an appropriate amount during pregnancy? I don’t want to take too much nor too little. Thank you so much!

  30. Jennifer October 28, 2012 at 10:53 pm # Reply

    Hi Dr. Ben,

    In my research for a good prenatal vitamin for someone with a single copy of C677T mutation, I have come across the Mega Food brand, and was wondering if you might have any feedback. It is a whole-food supplement. It appears that the folate is derived from broccoli, and many of the other B vitamins from s. cerivisiae (brewers yeast, as I understand it). Here is a link to their prenatal vitamin page:

    What is your opinion of the type/quality of folate and B vitamins derived from these food sources?

    Thanks so much for your advice,

    • Tricia June 26, 2014 at 3:49 pm # Reply

      Dr. Ben, can you please answer Jennifer’s question about MegaFoods whole food supplement? I want to know as well.

  31. Amy R November 1, 2012 at 3:12 am # Reply

    Dr. Ben,
    Any reason not to use Homocystex from seeking health while pregnant? Can you also help me understand the difference between Homocystex, sublingual active B12 and L-5 mthf?

    • Dr Ben November 5, 2012 at 7:29 pm # Reply

      Amy –

      You have to ask your doctor(s).

      To me, HomocysteX is fine to use while pregnant.

      The differences between the three products you mentioned are the ingredients contained.

      HomocysteX: contains 1000 mcg methylcobalamin, 800 mcg methylfolate and 25 mg pyridoxal-5-phosphate (B6)
      Sublingual Active B12 and L-5-MTHF: contains 1000 mcg methylcobalamin and 800 mcg methylfolate

      Some individuals do not do well with added B6 which is why I have this nutrient excluded in some of the other formulas. Some also do not need additional B6.

  32. Autumn November 1, 2012 at 3:41 pm # Reply

    Hi Dr. Ben,

    Three questions:

    1. I am taking Thorne’s Methyl Guard Plus. There’s multiple things in that. Do you like MGP, and if so, when I’m taking that, which of your recommended supplements do I NOT need?

    2. Like another mom asked, is there any reason you wouldn’t recommend MegaFood Baby & Me prenatal, a food-based prenatal. I know the folate in it is not all we need, but are there reasons it wouldn’t be good as a prenatal?

    3. Would any of your recommended supplements be contraindicated if a person tends toward excessive bleeding?

    Thanks for your podcast.


    • Autumn November 1, 2012 at 3:43 pm # Reply

      Forgot to say – homozygous C677T.

  33. Victoria P November 25, 2012 at 9:11 pm # Reply

    Dear Dr. Ben, I was diagnosed with 2 mutations several years ago after 2 recurrent miscarriages. One A1298c and one C677t. At that time, I was put on a regimen of Metanx, baby aspirin, Lovenox and progesterone. It seemed to do the trick because I now have a beautiful almost 4 year old son. We are trying to get pregnant again, but I am 38 yo, and seem to be having A LOT more trouble just getting the two blue lines. My current regimen is Neevo DHA, baby aspirin, progesterone. Lovenox after confirmed pregnancy. My questions are;

    1. Does age affect mthfr and change of supplementations for successful implantation/pregnancy?

    2. I just ordered some Fertile CM supplements from to help with my dereased cervical mucous. It contains Calcium(from Coral Calcium), L-Arginine, N Acetyl Cysteine, Grape Seed Extract, Lactolbacillus Acidophilus. Will this interfere in any negative way?

    Thank you very much!

  34. Katie November 28, 2012 at 4:11 pm # Reply

    I am currently 12 weeks pregnant after 1 healthy son and then two losses, one at 20 weeks and one at 7 weeks. After my losses, I was diagnosed as compound heterozygous MTHFR. I have been taking the Seeking Health sublingual B-12 with Methylfolate along with my prenatal, Vitamin Code RAW Prenatal. The prenatal is made from all whole, real food sources, and it says it has “Folate – 800mcg”. My OB took a look and thinks the prenatal is sufficient for my folate needs. My question is: What is the difference between Folate and Methylfolate? What difference does that make for a person with the MTHFR mutation?

  35. Eliza December 3, 2012 at 6:53 pm # Reply

    Hi Dr. Ben,

    I don’t want to make this too long so i’ll try to shorten as much as possible. I am currently 18 weeks pregnant, I was diagnosed by an RE in August the month we conceived with MTHFR A1298C. We saw our RE after we had our third Miscarriage. I am now seeing a perinatologist along with my OB and the perinatologist has asked that I take 500mg of b6 2x’s a day and 500 mcg of b12 once a day along with 81 mg of aspirin. The prenatal I take is OB complete which includes 1mg of folate. I feel like I’m taking too much b vitamin and I expressed that to the doctor but upon asking why so much he simply said that I don’t process b vitamins well and that was the proper dose to take. I am confused, is this too much??

  36. Tina December 16, 2012 at 7:15 pm # Reply

    Dear Dr Ben, how much vitamin B6 do you recommend with your above recommended “prenatal supplementation” protocol?

  37. Kris Mason December 26, 2012 at 3:00 am # Reply

    Hi Dr. Ben

    After our consultation in October, I’ve been taking the recommended prenatal, the Active B12 Lozenge with L-5-MTHF and the Active CoQH. I have tolerated them very well and my symptoms of tingling and numbness in the feet and hands have gone away. Thank you so much for the recommendations.

    I have two copies of the C677T, and have miscarried twice. I’ve also had one failed IVF procedure. In the past my doctors recommended lovenox, baby aspirin and high doses of folic acid. Since speaking with you, I now know better about the folic acid,and have decided on the new regiment listed above. In one month ,I will begin my second attempt at IVF and am wondering if I should switch to the Homocystex Plus in place of the lozenge?My vitamin D3 is low, and I am taking the Prenatal Essentials vitamins. Is the vitamin D in that prenatal sufficient, or should I also start on the D360?

    My goal is to have a healthly baby. We’ve been trying for 5 years, with one obstacle after another. I feel like once I received all of that valuable information from you and the website, that at least we have a chance now. Thank you for everything!!!

    Looking forward to hearing from you.

    • Dr Ben December 26, 2012 at 3:29 am # Reply

      Hi Kris –

      Great to hear you are doing better ;)

      I would recommend the HomocysteX Plus. That is a good idea. I suggest you consider this as well because it has additional riboflavin and methylation support which may be useful right now. Start low and work up. Do use it instead of the lozenge for now. Again, see how you feel and adjust how many you are taking with your symptoms. Work with your doctor on this.

      There is no multivitamin that I have seen that has enough vitamin D3 in it. I do recommend the liquid vitamin D – and at least 3 drops a day – which provides 6,000 IU. You may take it anytime. If your vitamin D3 level is quite low, your doctor may have you take 10,000 IU a day or more. Do follow their recommendations and be sure to retest in a few months.

      Be sure to continue supporting yourself thoroughly all the way through pregnancy and breastfeeding.

      Do consider the Optimal Liposomal Vitamin C as well as it has additional choline in it as phosphatidylcholine – plus liposomal vitamin C. Consider taking 1 to 2 tsp daily.

      Do look into taking a fish oil or at least measuring your red blood cell fatty acid content. It is important for these to be balanced.

      Keep me posted how you are doing!

      • Kris Mason December 26, 2012 at 8:30 pm # Reply

        Thanks Dr. Ben. I appreciate your quick response. I will definitely keep you posted.

  38. Summer Bonnet December 26, 2012 at 4:23 am # Reply

    Hi Dr Ben,

    I have two questions, other than mood temperament (which I was affected with at first, but do not seem to be now) is there any other adverse effects of taking too much methylfolate? and is taking all the supplements in your podcast and including your optimal multivitamin (instead of a prenatal multi) good enough?

    I am taking all of the above Supplements mentioned in podcast. Dosage of the L-5-MTHF is one in the morning and one at night as well as one folinic acid (perscribed by my naturopath) at lunch.

    I do not take a prenatal Multivitamin as I can not get hold of Thorne Basic Prenatal or Xymogen Prenatal Essentials in Australia. I alternate between your Optimal Multivitamin (around 5 a day) and Mulit Diocomplex (which my naturopath recommended – it includes in its list folic acid and cyanocobalamin – so unsure on it).

    Thanks Summer

    • Summer Bonnet December 26, 2012 at 4:24 am # Reply

      Also do you recommend B6?

  39. Meg January 6, 2013 at 3:14 am # Reply

    Thanks for all your help, I have been reading through your site all night.

    I have MTHFR, Factor 5, and a possible thyroid issue. I lost our first baby at 9 months pregnant, since then I have had 3 healthy full-term pregnancies. We also hope to have more children in the future as well.

    I am a bit confused. My Dr. and my specialist told me last year that the new research said Lovenox does not make a difference during pregnancy (for MTHFR patients). They did put me on folic acid and baby aspirin.

    Now after reading this, I know the folic acid should be avoided, and I am starting to think I SHOULD be taking Lovenox during pregnancy.

    Anyway, Right now I take the following:

    1. New Chapter Prenatal (no GMO’s which is important to me)
    2. Probiotic
    3. Fish Oil
    4. D3
    5. Carlson Tri B (B6 + folate + B12)

    We also eat very healthy and juice daily. Can you let me know if this looks OK? I am a bit confused as to which Methylfolate is right in the seeking health online store.

    Thanks so much!

  40. Kris Mason January 14, 2013 at 6:12 pm # Reply

    Hi Dr. Ben,

    I have been taking the Xymogen Prenatal Essentials and I tolerate it fine but they are a bit costly. I noticed that you have added another recommendation, Thorne Basic Prenatal which is considerably less expensive. Can you tell me if one is better than the other as far as quality and what benefits they provide?

    If Thorne is just as good as Xymogen, I could save a few dollars and use Thorne. But if Xymogen is better, I’m fine with paying the price for it. I would like to get your input on this matter.


    • Andrea January 16, 2013 at 4:19 pm # Reply

      hi Dr Ben!! I just took the Active b12 Lozenge and started shaking,is that normal because it is the first time????

      • Dr Ben January 16, 2013 at 9:24 pm # Reply

        Andrea –

        I highly recommend that people start very slowly on methylation supportive nutrients as they can be potent.

        I also am now recommending that people take methylation supportive nutrients within 20 minutes of eating. This is because methylation supports neurotransmission and if your blood sugar is imbalanced, then it may cause shaking or irritability.

        Do let your doctor know how you responded to the B12 and how much you took – and if you took it around a meal or not.

        To counteract the many potential side effects of methylation support, niacin may prove useful.

        • Andrea January 20, 2013 at 1:59 am # Reply


    • Dr Ben January 16, 2013 at 10:03 pm # Reply

      Kris –

      I prefer Xymogen’s hands down.

      • melissa January 20, 2013 at 6:45 pm # Reply

        Hello Dr Ben,

        I have a question for you, I have had 7 now 8 pregnancy no miscarriages. My 7th pregnancy our daughter was stillborn at 41 weeks from a placental abruption. I have had no other problems with my other pregnancy’s. After our daughter was born I asked to be tested for all clotting disorders including MTHFR. The only one that came back positive was the MTHFR and I have one copy of the C677T gene. I am currently 19 weeks pregnant. I am currently taking

        Thorne Prentals 1 capsual should I be taking all 3?
        Metax 1mg

        Should I be taking fish oil and COQ10?

        My OB has not suggested asprin or blood thinners, due to no other clotting disorders or recurrent misscarriages. Should I be taking taking asprin or blood thinners to prevent another abruption? Also so far my ultrasounds are showing all is good with this pregnancy and placenta. Thanks

      • kirsty December 4, 2013 at 4:37 am # Reply

        Dear Dr Ben,
        Have one copy of MtHFR, think ends in 167. Need to retest other copy as wasnt tested here in Australia. I am high positive for Anticardiolipin IgG and factor v lieden. I had lupus Nephritis at age 12 but in remission past 15 yrs but have secondary Antiphosholipid syndrome. My father gave me fvl. I suspect mother MtHFR as she is hypothyroid and had a dvt when 7 mths pregnant
        With myself and has thickened blood. I’ve had sluggish thyroid andafter miscarriages i went onto replacement both t 3 and t4. I’ve improved. Unaware I couldn’t methlylate. and knowing that maybe I’m loosing to this.
        I be battled infertility and poor implantation on ivfcycles.Ihave recently known of my MtHFR and started folinic acid daily. My ferritin low so had iron infused and is good. I had borderline.low vit d and its come back up after 10000 iu. Now on 4000.
        I need know if I need all the supplements recommended by you and how do I get how do I buy in Australia. Look forward hear from you.

  41. Summer Bonnet January 28, 2013 at 6:45 am # Reply

    Hi Dr Lynch,

    I live in Australia, the freight from the US is costly. Are you able to sell your products through iHerb? Thanks Summer

  42. Christy January 30, 2013 at 2:01 am # Reply

    Hi Dr. Ben,

    I am homozygous c677t and am following your protocol for general health with the intent to try to get pregnant in the next few months. I just ordered Homocystex and was wondering if I can take this during pregnancy in addition to the Thorne prenatal or if you recommend dropping back to the sublingual b12/methylfolate?

    Thank you!

  43. Jennifer February 8, 2013 at 3:12 pm # Reply

    Hi Dr. Ben,

    I just ordered the Xymogen Prenatal Essentials, and I see they come in a pack of 4 capsules plus 1 DHA capsule, but with no instructions for taking them, except to “follow the directions of your doctor”. I even tried calling the company, and they were not able to give me any better idea on when to take the various capsules. Common sense, plus what I have read on this forum, is telling me they are not to be taken all at once, but rather spaced out, but I’m wondering if you can give your advice on the best times to take them – i.e. how far apart – with or without food, etc.? Thanks so much for your input.

    • Elizabeth February 15, 2013 at 8:44 pm # Reply

      Dr. Ben,

      Thank you so much for all of your research and information regarding MTHFR. My husband and I have lost 6 children to miscarriage in the past 2 years and are currently 5 weeks pregnant. I just discovered your website ( wish I had sooner). I have compound heterozygous MTHFR. My doctor has me taking a compounded capsule filled with folic acid, B6 and B12. and I’m taking Lovenox 40mg daily and a baby aspirin. My doctor has me taking an over the counter prenatal along with 500mcg of extra folic acid. To make a total of at least 1,300mcg of folic acid not including what he puts in the compounded capsule he prescribed me. After reading your website and listening to your podcasts I feel that I am taking all the wrong things. I want to save this little one we are pregnant with!

      Does your list of supplements during pregnancy take the place of a prenatal or is it in addition to a prenatal? Also, can the Optimal Multivitamin Chewable take the place of my prenatal? or would I need more supplementation?

      Thank you so much!

      • Nadia May 23, 2013 at 5:13 am # Reply

        Just wanted to reiterate this question, as I have it too after listening to your podcast, and noticed others asking the same question in various forms:

        Does your list of supplements during pregnancy (1-10) take the place of a prenatal entirely, OR is it to be taken in the full amounts stated in addition to a recommended prenatal on your list, OR are we to supplement a recommended prenatal with the listed items (1-10) to reach the total stated amounts?

        I assume your list is in additional to a prenatal of some kind, as you mention in the podcast, the importance of sufficient iron, and the benefit if chia seeds and chlorella? But it’s not clear what the relationship is between items 1-10, and the recommended prenatals you’ve listed.


  44. Summer Bonnet February 19, 2013 at 9:11 am # Reply

    Hi Dr Ben,
    I am c667t hetero, multi miscarriages, I am taking the L5 metafolin, b12 methycobalamin and the rest of the recommended list of prenatal essentials – I rattle when I walk and happy to do so for my body to function properly!!! I have just found out I have Pyroluria and I am wondering how many other people with the MTHFR mutation also have Pyroluria? Is there any magic suppliment that you feel is vital when someone has both Mthfr and Pyroluria?
    Thanks a bunch – your recommended list of suppliments have already helped me with anxiety, hopefully they can help me have a healthy baby – or if the risks are too high at least you have enable me to have understanding and allowed a healthier future. Again, thank you for your passion and will for a better future – for everyone.

  45. Danielle Netherton February 26, 2013 at 9:31 pm # Reply

    I notice that in the thorne prenatal you recommend it contains vitamin C in the form of absorbic acid. Why are you not recommending a whole foods based vitamin?

  46. Danielle Netherton February 26, 2013 at 9:39 pm # Reply

    is it ok to take these supplements if you *dont* have the mutation?

  47. Jennifer March 5, 2013 at 4:09 am # Reply

    I was recently diagnosed with Homozygous MTHFR and am 16 weeks pregnant. I’m on lovenox, baby asprin, Folgard and a prenatal + DHA. Is it too late to make the change to the supplements you’ve suggested? I’m concerned about the links between MTHFR, folic acid and Autism. Thank you!

  48. Adrienne March 19, 2013 at 6:40 pm # Reply

    I am so glad to have found this site. My 2 year old son has chronic feeding issues and a major lip tie and suspected tongue tie as well that we just discovered. I too had a lip tie that tore and have slight tongue tie, which I thought was normal until now. After learning the link between that and MTHFR mutation, I want to make sure that I do everything right for my next baby. We only have temporary insurance right now, but we plan to get tested as soon as we can. In the mean time, I want to start taking a safe pre-natal vitamin now because we plan to have another baby soon after we get insurance through an employer. I am thinking of getting the Thorne Basic Prenatal…would there be any harm in taking this if I for some reason do not have the MTHFR mutation? Do I need to take a DHA capsule in addition to this? Also, is there a chewable or gummy children’s multi-vitamin you would recommend for a 2 year old with suspected MTHFR mutation that already drinks 1 pediasure/Kids Boost a day? Thanks so much!

  49. Eve April 12, 2013 at 9:34 pm # Reply


    Sorry – Just wanting to clarify. We are to do the whole list (going slowly) in ADDITION to the prenatal? Just wondering if the sublingual b12 would be too much in addition to what is in the Thorne (which I am taking). The combo of the sublingual and Thorne are ok then as far as b12 and MTHF when pregnant and breastfeeding (I am still breastfeeding my 24 month old)? Thanks.

    I am considering the xymogen bc the Thorn seems to have so much iron, although it does not constipate me. I just don’t like the mag. stearate in the xymogen. Is Dr. Ron’s “Docs best multi” and desiccated liver an ok alternative?

    Thanks for all that you do, wondering if your book is out soon?


  50. Eve April 15, 2013 at 5:12 am # Reply

    Also wondering if Cod Liver Oil is a good option for fish oil, specifically fermented cod liver oil (for example when on GAPS).

  51. suzy May 15, 2013 at 12:58 pm # Reply

    Hi, I am taking the Prenatal Essentials from Xymogen that you have listed here as a recommendation, do they contain the correct for of folate?
    I see my label says “Folate- (400 mcg as (6s) -5-methyltetrahydrofolic acid, glucosamine salt and 400 mcg as calcium folinate”

    Which ends in “acid” not “folate”.

    I just want to be sure I am taking the correct form. Also what should I add to my prenatals from the above list? Do I need more folate/B12? I am not sure what else to order.
    Thank you

  52. suzy May 15, 2013 at 8:23 pm # Reply

    Hi Dr. Ben
    The Xymogen Prenatal Essential vitamins say “Folate- (400 mcg as (6s) -5-methyltetrahydrofolic acid, glucosamine salt and 400 mcg as calcium folinate” is this an ok form of folate?
    Also, should I add the L-5-mthf and b12 sublingual listed in the above list for my prenatal plan?

  53. Nadia May 23, 2013 at 6:07 am # Reply

    In your supplement list item #2, did you mean to write “1 mg of methylcobalamin?”

  54. Sheri May 25, 2013 at 6:52 am # Reply

    I am 34 years old and was recently diagnosed with having compound heterozygous mutations after requesting the test be done by my obgyn (4 miscarriages later). Previously I asked my primary care physician to test for the mthfr mutations, d3, b6, b12, folate, copper and zinc, etc., and again asked the hemotologist that my primary physician referred me to to test for the mthfr. The hemotologist looked over the blood clotting tests that were done by my primary and said that since my homocysteine levels were normal, antibodies were good, and I didn’t have leiden factor v that I didn’t need to test for mthfr. He said that they don’t really test for it very often and don’t really see a need. Luckily my obgyn agreed to test for it but at the same time I am discouraged that she prescribed the standard protocol of 4 mg. of folic acid/daily. She did not think that I needed a b12 vitamin and did not seem knowledgeable about the methylcobalamin form.

    My history: I have had 2 uneventful live births that I took for granted, 2 miscarriage (one at 6 weeks and one at about 9 weeks), 1 live birth, 2 miscarriages (one at 8 weeks, baby was 2 weeks behind, but did get to see heart beat at 2nd ultrasound and then started to miscarry that night-I took progesterone and the other miscarriage was at 4 weeks- I wasn’t on progesterone), and am now 6 weeks 4 days pregnant, back on progesterone. I am not considered to be high risk; they said that miscarriages are normal. I was told to go get pregnant and come back and see my former obgyn and the hemotologist said to get pregnant and come back to tell him all about it. Very frustrating to hear that when I know something is not right. This pregnancy I have been trying to take it easy but it’s hard not to worry. At my 6 week 2 day ultrasound they found subchorionic bleeding 3.5 cm and told me this is normal and not to worry. I am concerned because I do not know if I am producing clots even though the tests show differently. I have talked to the doctors for 8 years about my periods being clotty, since after my second child (live birth). I have now been to the same hemotologist twice to go over the blood clotting testing panel. I have been told that its all normal.

    Currently I am taking 125 mcg levothyroxine (hypothyroidism since 17 years of age) pharmaceutical grade fish oil 2 x daily, natural progesterone transvaginally after inquiring with obgyn a year ago, vitamin code whole food prenatals, wobenzym, vitamin k2, and d3 standard doses. Previously I was taking the active form of b6, metafolin 1600 mcg every few days and 800 mcg on the other days, 8,000 d3, pharmaceutical grade fish oil 2x daily, and vitamin code womens whole food vitamins. I just started researching mthfr and was confused as to what to do. The tests that I mentioned above done by my primary came back with my vitamin d3, b6, and folate being too high. Not surprisingly the folate was at 45, very bad on my part. I am also concerned that maybe my blood is too thin and is causing the subchorionic bleed. I’ve seen wobenzym n on other websites but not on your protocol for mthfr. I questioned my obgyn today as to why she wanted to put me on the high dose of folic acid when my previous tests showed that my folate was high and was told to stop taking any additional folic acid or folate. She said the bloodwork doesn’t actually show the amount of folic acid in my blood. I asked her about the possibility of a methyl trap and she said no, all is well and she’d feel more comfortable with me taking the folic acid, instead of the l-methylfolate because theres lots of research that shows the folic acid helps those with mthfr. However I found it interesting that she mentioned Deplin as an alternative option but said it was very expensive. I do not understand why she does not think that metafolin would work at a comparable dose to the 4 mg of folic acid she prescribed. Is there anything that I can do to help this pregnancy be successful? I am still learning. There is so much information to do through. Also do you know of any knowledgeable doctors in the Salem Oregon area for mthfr mutations? I would like to get the full panel tested. I am concerned that I possibly have the cbs mutation, etc, because I read that it can make the homocysteine levels normal. Thank you so much for the time and effort that you have put into helping people find truth. God Bless!

  55. Sheri May 26, 2013 at 8:15 pm # Reply

    I should have also included the lifestyle changes that me and my family have made since that is a very important piece to achieving healing. We switched to organic in our household over the last 6 months (starting after my miscarriage on November 5, 2012). I also take a probiotic with 50 million live activce cultures that has several strains. I also started taking epson salt baths a couple of months ago and using body brushing and massages. I took evening primrose to conceive on my most recent very early miscarriage, and currrent pregnancy, stopping after ovulation. Yesterday I picked up some sublingal active b12 (they only had it solo or with folic acid, so I opted for solo) and CoQ10, enhanced absorbption softgels (I meant to get the ubiquinol :( ), and natto-k. I already have metafolin and p5p. I wasn’t planning on taking more p5p, since it seems there is enough in my prenatal vitamin code vitamins? I wanted to follow the protocol I saw in one of your posts for individuals who have experienced multiple miscarriages. Taking 2 sublingal b12 upon rising and 2 before lunch and then to add up the methylfolate to equal 4 mg. I feel comfortable taking the natto k instead of aspirin with what I have read but am concerned with having my blood too thin because of the 400 iu vitamin e I’m taking to help with my subchorionic bleed (sac separated from wall slightly) to heal, the pharmaceutical grade fish oil I am on, and the wobenzym n I am taking. I have considered stopping the wobenzym n but am worried because many in my family have inflammation and I have always kept a low grade fever with all of my pregnancies that seems higher than a normal pregnancy temperature and have experienced joint pain throughout my life that definately improves when I stay active. I also read on one of your articles that inflammation effects the way natto k may work. I cut back on the wobenzym n to 3 tabs once a day instead of twice and started taking 50 mg of natto k last night. I am also now taking 1 mg of sublingal b12 twice a day and 1600 methylfolate, to work up slowly to the higher amounts. I am writing my life story. I have not been able to find support and accurate information anywhere else. Am I on the right track? I saw that a women used 100 mg a.m. and p.m. instead of aspirin and/or lovenox and it worked for her. I wonder if that will work with all that I am taking. One final question. I have seen mixed reviews on epson salt baths during the first trimester. I feel that they are necessary and have continued them 3 x a week but with only 1/4 cup. Thank you so much for hanging in there if you have read my postings and for any input.I’ve learned a lot from the articles and comments but am still learning.

    • Sheri May 26, 2013 at 8:35 pm # Reply

      Oops, I meant to say that I saw a women in one of your posting who used 100 mg of natto k a.m. and p.m. instead of aspirin and/or lovenx and it worked for her.

      I hope that taking the methylb12 will help with my elevated folate (took metafolin), when I was taking 1600 mg in the past. I really feel that I have a problem with clotting since my periods were very clotty before my pregnancies and have gotten worse and shorter over the last 8 years. Since I can’t take Homocystex during pregnancy due to the high amounths of TMG, I hope that getting the proper amount of methylfolate and methylb12 will help with possible factors (e.g. s-adenosylhomocysteine, etc.) that may also influence clotting factors, especially during pregnancy when it seems the autoimmune system goes into overdrive.

      • Sheri January 11, 2014 at 10:27 pm # Reply

        Update: I am 40 weeks 1 day pregnant today. I took raw prenatal vitamins (Vitamin Code) and pharmaceutical grade fish oil the entire pregnancy. I watched what I ate and took vitamin E and/or vitamin k2 when I ate food on the clotting list they give to people who take warfarin. I also stayed away from green tea that has been said to effect folate absorbancy. I didn’t take the 4 mg of folic acid prescribed by my dr. My subchorionic bleed was compleyely gone by 20 weeks. I did bedrest for about 12 weeks and took it easy til it was gone. I think the Wobenzyn was too much in the beginning. I just wanted to give an update. I also started water aerobics, took epson salt baths, ate mostly organic and used organic products, and drank red raspberry tea the third trimester. Hope delivery goes well!

  56. Colleen May 31, 2013 at 4:20 pm # Reply

    Hi Dr. Ben,

    I’m a 33 yr old TTC, 2 previous miscarriages, an insulin dependent Type 1 Diabetic and have the MTHRF Heter A1298c gene. Would you suggest any additional supplements to the above mentioned (including Xymogen Prenatal).

    Thanks a million for all of your work!

  57. Meghann June 8, 2013 at 3:07 am # Reply

    I am heterozygous for the A1298C mutation and found out after losing my last baby. I have one healthy baby and my last baby had a neural tube defect discovered at 15 weeks. With my first pregnancy, I took Neevo DHA. My latest pregnancy, I was taking Rainbow Light prenatals and an extra 400mg of folic acid (just because I wanted to make sure to have enough). My doctor has recommended neuromethylation cream which has 5-mthf in addition to continue taking the rainbow light prenatal, vit d drops, vit c 500mg, a probiotic and a digestive enzyme. I see that your recommendations are different. How does this cream compare to the sublingual that you recommend?

  58. Devyn June 12, 2013 at 1:16 am # Reply

    I sadly had a 3rd miscarriage in March and am now going to try NeevoDha. I was diagnosed with a single mutation of the C677T in April and no Dr.’s seem to think it’s a big deal which is crazy to me. I’m trying to be proactive with my own health and future pregnancies at this point and just wanted to know what else I should be taking in addition to the NeevoDha since this recent diagnosis. I’m so confused. Thank you.

  59. Anna July 8, 2013 at 1:28 am # Reply

    Hi Dr. Ben,

    Regrettably I cannot listen to the podcast, so I have to do only with the written info on your website. I am just a bit confused about the prenatal list. Do you recommend to take 1 to 10 supplements PLUS a prenatal multi vitamin such as Thorne? Or is it either/or?
    I have compound heterozygenous MTHFR (just found out two weeks ago), I am 5,5 weeks pregnant currently and I want to give this little one the best chance at life, but I am just a bit confused. Hope you can help me out. (or anyone else who knows the answer)

    Currently I am on folinic acid (385 hm?) and I take 100mg of aspirin. I try to eat as much green leafy veggies and lentils as possible, but I am so worried it is not enough. I have just ordered the Thorne Prenatal last week, waiting for it to arrive.

    Should I add methylB12 to it? Should I add P5P to it? It looks to me the required doses are already in the multi vitamins, but I am not sure.

    Also, some people have suggested Lovenox to me, but my doctor told me I don’t have a blood clotting disorder, so not sure if I should have this blood thinner?

    I have had two early miscarriages and two missed abortions in a row. Four years ago I did give birth to two little boys who are healthy now, but I had severe pre eclampsie and my boys were very much under fed when they were born. Now I recently have been given diagnose of low egg cell reserve (feels like this might be my last chance) and MTHFR.

    So far, I have been unable to find a doctor here in Perth, Western Australia, who takes this gene serious and is willing to help me out. It has caused a proper panic in me, as I really want to do the right thing, but I just can’t figure out exactly what that is. I hope someone here can help me figure this thing out.

    Thanks for your time, Anna

  60. Allison Garfinkel July 21, 2013 at 1:50 am # Reply

    I am concerned about taking vitamin K when I am homozygous MTHFR 677. Doesn’t vitamin K promote blood clotting? I am trying to conceive, just had my second miscarriage and my doctor wants me to take daily baby aspirin and possibly lovenox to prevent potential clotting issues in early pregnancy which he suspects to be the issue. I was prescribed Neevo DHA but after listening to your podcast it sounds inferior to the other prenatals you’ve recommended. Please explain further why vitamin K is necessary and not harmful in my situation. Thank you!

  61. Annemarie September 13, 2013 at 5:31 pm # Reply

    Hallo Dr Ben,

    I have just found out that I am A1298C Homozygous. I have a history of migraines with aura since early childhood. I am 35yrs old and have 3 sons. I had no miscarriages, but had severe pre eclampsia and HELLP syndrome with my 1st(born31wks) and 3rd son (29wks). With my middle son I had no problems and delivered @40wks. I took aspirin with pregnancy 2 and 3 and with no2 took high amounts of fish oils and ate Salmon almost every day. I took a little bit less fish oils with no 3. We really want more children, thus

    My questions are:

    1. I am willing to take every supplement as you listed it. Should I still take aspirin or lovenox?

    2.I have recently studied a supplement called Eckonia Cava Seanol that lowers the viscosity of the blood and is a great anti-oxidant. Can I add it to your list?

    3.What do you think of using a supplement that raises nitric oxide like a l-citrulline beetroot nitric oxide chewable?

    4.What do you think of using enzymes like Wobenzymes. I know there are some risks like miscarriage with some enzymes, but the other day I read an article that said you could use it through pregnancy.

    5. Could you do far-infrared sauna while pregnant?

    I really appreciate any of your recommendations. Thank you so much for taking the time to read this.

    Kind regards
    South Africa


  62. Sarah September 15, 2013 at 2:54 am # Reply

    Dr. Ben,

    My husband and I are both homozygous for MTHFR C667t. We have been going through fertility treatments over the last year. Our RE said that as long as I take 3mg of folic acid and a baby aspirin daily we should be just fine in terms of the MTHFR. So I have been taking Actifolate from Metagenics. I take 3 tabs a day in addition to my prenatal vitamin. My husband also takes 2 actifolate a day. In addition, he and I have both been found to be vitamin D deficient and have been on supplements off and on for this. I have talked to my RE about my concerns about possible autoimmune problems that may also be affecting our fertility. He mentioned possibly adding heparin/lovenox after our IVF transfer. I guess I have the following question, Is actifolate sufficient or should I be on a different folic acid supplement? The last thing I want to do is go through our final attempt at IVF with ICSI and have it fail because I am not receiving the right type/amount of folic acid. Thanks in advance for your help.

  63. Sarah November 4, 2013 at 8:52 pm # Reply

    Dear Dr. Ben,
    I am Compund Heterozygous and have Factor II. I have had 2 miss-carriages in the past 4 years, one failed IUI, and will start a new IUI this month.
    I take 1 Baby Aspirin, 1MG of L-5-MTHF, and Thorne Prenatal. Is this enough for my gene mutation? I used to be on 15MG of Deplin(generic) and Neevho DHA and my OBGYN said this was way too much. Can you please advise me if what I’m taking is correct and will help me have a successful pregnancy? This is all so confusing and a lot of Dr.’s here do not know very much about this mutuation or give you different answers. I do not want to miss-carry again due to this mutation. When I do become pregnant my RE will have me take Lovenex for the first trimester as well.

    Thanks! Sarah

    • Cassie November 5, 2013 at 11:07 pm # Reply

      For the Factor II you probably should add Lovenox or another similar anticoagulant. Factor II is very similar in clotting nature to Factor V Leiden (which I also have along w/one of the MTHFRs). FVL is routinely treated prophylactically with anti-coags in pregnancy. Feel free to message me off the group if you have questions about it. I have taken it in 2 pregnanancies after having a 2 losses and a 29w preemie without it.

  64. Julia November 17, 2013 at 6:05 am # Reply

    Hi Dr. Lynch, I have a question for you about prenatal supplementation.

    My husband and I have started our first IVF cycle and we have never been tested for MTHFR, but I would like to be after reading more about it. It looks like the test takes 6-8 weeks for processing, however. My RE has prescribed Folic Acid 1mg/day but this appears to be synthetic and non-methylated. Would you recommend I take some methylated folate in addition to or instead of what was prescribed as a precaution? If I take the methylated form, does it do any good to take the prescription I have? As I read through some of the symptoms, some of them hit home and I’d like to do everything possible to make this attempt a success and protect the health of my offspring. Thank you so much!

  65. Adriana January 11, 2014 at 9:36 am # Reply

    Hello Dr. Ben,

    I have been tested positive for MTHFR C677T and MTHFR A1298C both heterozygous. I’ve lost 3 pregnancies. My doctor gave me Femibion which contains folic acid, Metafolin, vitamins and iodine. I also take 1000 mg Omega 3 per day. He said that I should also take 1 Clexane injection per day as soon as the pregnancy test turns positive until I give birth. Please be so kind and tell me your opinion about the treatment. Should I also take vitamin C and magnesium or anything else considering my problems? Thank you very much for your time and answer.

    • Maria April 13, 2014 at 6:22 pm # Reply

      Hi Adriana,

      I want to give you some hope :) I have suffered 2 miscarriages and been diagnosed as homozygous for MTHFR C677T (they checked for many other things but everything else was ok). I am 36 weeks pregnant now (very healthy so far) and i have been taken Femibion and low-molecular-weight heparin (as Clexane) the whole pregnancy. I also take 2000 mg Omega 3 per day. I am not a doctor, but i think the Femibion contains vitamin C and magnesium enough so you don´t need to supplement.

      Best of lucks with your next pregnancy!

  66. Julie January 26, 2014 at 2:56 am # Reply

    In your audio I heard you say for calcium could also take moringa. I was reading on this website: to not use moringa flowers during pregnancy. I wasn’t sure if you had heard that.
    Anyway thank you for all of the valuable information!

  67. Erin January 27, 2014 at 3:11 am # Reply

    Hello Dr. Ben,

    I am homozygous C667T. Had 3 miscarriages before being diagnosed. I currently have 2 little ones and I’m nursing my baby. They gave me Folbic and VitaMed MD during my pregnancy but from one of your responses above I see that Folbic is insufficient. What should I be taking as a nursing mother? Thank you!


  68. Heather January 30, 2014 at 9:23 pm # Reply

    Dear Dr. Ben,

    I was recently diagnosed with heterozygous A1298C MTHFR mutation. I am guessing the supplements you list above will be helpful for me, though my current OB only told me to take one baby aspirin daily (I am in the process of making an appointment with an RE as I have suffered a miscarriage and cannot emotionally go through that again). I am wondering what your suggestion is about how long I should be on this regimin before trying to conceive. This same OB told me we could conceive right away, as I am on my first cycle since the miscarriage. However, I am worried my body hasn’t built up all the nutrients it seems to be not absoring and/or missing. What is your recommendation? Thank you so much.

  69. Nicole Oldfather February 14, 2014 at 3:52 am # Reply

    Dr. Ben
    I had a healthy baby in 2001, but he was induced early d/t pre-eclampsia. Then in March 2005 I miscarried at 23 weeks, however they said the baby measured at 17 weeks. Again in Nov 2005 I miscarried at 16 weeks, baby measure 13 weeks. I was then tested for clotting disorders and had genetic testing done. The only thing found was MTHFR, but I don’t know what type. In Feb 2006 I got pregnant with my daughter and saw a perinatologist who put me on Lovenox, but said MTHFR had nothing to do with my losses and my ob/gyn believed the same thing. She was born healthy and no pre eclampsia that time. Then in Nov 2013 I was 18 weeks and lost the baby. I had been taking Heparin since I found out I was pregnant. That time I was seeing a maternal fetal medicine specialist who also did not believe that MTHFR had anything to do with my losses and she didn’t even want me to take the Heparin, but my ob doc agreed to keep prescribing it for me anyway. After the loss my ob/gyn told that if I got pregnant again she would not prescribe the Heparin since I miscarried even though I was taking it. Could you comment on blood thinners and still miscarrying? Also, I would like to have another child, I’m 37, but every doctor I have been to thinks that MTHFR is nothing to be concerned about, it’s very frustrating. I am just now really educating myself through your website. I think I saw mentioned that you do phone consultations, is that correct?

  70. Stephanie February 15, 2014 at 3:18 am # Reply

    What is a good iron supplement since the Optimal Prenatal doesn’t have any? The one I took while pregnant with my daughter was Mega Food and has folate and vitamin b-12 in it. My iron levels during both my pregnancies have been low so I know I need extra. Thank you!

  71. Kimberly March 4, 2014 at 1:24 pm # Reply

    You stated with regards to Sublingual B12: “Sublingual Active B12 with Methylfolate: provides 1 mg of methylfolate and 800 mcg of methylfolate in a small sublingual tablet.

    I think you meant to said 1mg methylcobalamin and 800mcg methylfolate. :-)

    • Dr Lynch March 4, 2014 at 10:18 pm # Reply

      Hey Kimberly – yes – you are right :) Good catch – I will fix

  72. Michelle April 5, 2014 at 9:14 pm # Reply

    Dear Dr. Lynch,

    After being diagnosed with MTHFR heterozygous C677T with ACE deletion homozygous the hematologist I went to advised me that he didn’t think it would be possible for me to get pregnant. The fertility doctor I was seeing thought by implanting the embryo she could circumvent the issue, but after undergoing a failed IVF cycle and then trying on my own, I can tell that the embryo is trying to attach, but haven’t been able to obtain a positive test and end up losing it after being a week late in my cycle. Through all of this, I’ve also discovered that I can’t take baby aspirin, Lovenox or the other typically prescribed blood thinners, due to my allergy to NSAIDS. I tried Vitamin E, but broke out in red spots on my face. I saw Nattokinnase on one of your lists, but I’m unsure of how much I should take and if there are any associated risks. I feel like the Nattokinnase may be my last hope. I have been taking Neevo, Glutathione, DHEA and COQ10 for over 6 months now as recommended by the fertility dr. I also take Zyrtec-D and Zantac for my allergies and get allergy shots every 3-4 weeks, which my doctors seemed to think it would be ok to continue if I were to get pregnant. Any suggestions you could make would be greatly appreciated.

  73. Cassie April 8, 2014 at 1:50 am # Reply

    Have you tried Arixtra? It is a synthetic LMWH that people take when they are allergic to Lovenox.

    I take nattokinase regularly. I was taking it at the beginning of my last pregnancy along with Lovenox. I emailed a doctor who had done research on natto and felt like it was safe for pregnancy. If you look way back thru the history of it, it has been used thousands of years in eastern medicine for pregnancy, the real natto food that is.
    I was still nervous about taking too much so I cut out the natto and stayed on the Lovenox. Exactly a week later I had a superficial clot in my leg ( I have FVL in addition to MTHFR). I ended up on a triple dose of Lovenox as a result.


  74. Lauren April 10, 2014 at 1:11 pm # Reply

    Hello, I am quite nervous after finding your past writings. I had 2 miscarriages last year, one @ about 6 weeks and one @ 9 weeks after the heart had developed and we had seen the baby, however the heart was never strong. I was tested for the standard bloodworm at my OB and discovered I had the A1298C mutation. I then went to my wellness dr and had a ton of blood work done. My serum folate was >24.0, vitamin b-12 996, homocysteine 6.0.
    I am currently taking 200 mg progesterone, raw prenatal vitamins (contain .8 folic acid) and Nordic naturals fish oil. I have been taking 1mg folic acid since week 3 – I believe now it was a blind prescpition writing – meaning – you have mthfr- and I don’t know much about it- so here is folic acid. I’m 6.5 weeks and haven’t taken my folic acid this am. I’m scared to take it- after reading this page & other info re autism and excess folic acid…
    Thoughts? Please help!
    Thank you, Lauren

    • Lauren April 10, 2014 at 6:36 pm # Reply

      Correction – my prenatal is 800 mcg folate

  75. Maria April 13, 2014 at 6:08 pm # Reply

    Hi Dr Lynch,

    I am a 29 years-old that has suffered 2 early miscarriages (after seeing healthy heart beat). After my second miscarriage i was diagnosed homozygous C677T for MTHFR. I live in Spain and I am currently pregnant, I am taking Femibion 2 (with Metafolin) and low-molecular-weight heparin. I am soon moving to Australia, and I’ve seen that i will not be able to buy Femibion there. Could you advice me what prenatal multivitamin or just what metafolin supplement could i buy in Australia? I´d appreciate advice from people from Australia too :)

    Thanks you for a wonderful webpage!

  76. Ronald April 25, 2014 at 11:55 am # Reply

    To whom it may interest,

    My daughter was extremely happy to find she was pregnant a year or so ago. Sadly she miscarried in about the 8th week. She became pregnant again, was even more excited and then MC even sooner at about one month. To say the lest she and her husband were disappointed.

    She found a new doctor who gave her a battery of tests. The culprit was soon discovered. She is a double homozygous for the MTHFR gene. We found this to be a curious mixture of good and bad news, unhappy to learn the facts of our flawed genetics but armed with the knowledge that it could be treated.

    As treatment her fertility Doctor insists on her taking supplements of Folic Acid. This flys in the face of everything I have been reading on this site and others. I was under the impression that the condition blocks the conversion of folic acid to other chemicals and in fact can produce unhealthy chemical by products ( I should mention my daughter survived Melanoma at age 19). I encouraged my daughter to talk with her MD about the idea of Methyl Folate as a supplement instead of folic acid.

    The problem is he flatly refuses. He even went on to make an analogy that since her conversion of folic acid is reduced then he must increase the volume much like dumping a larger amount of sand so that more of it will get squeezed through a small bottle opening. He also claims to have a high success rate with Folic Acid with his MTHFR patients.

    In conclusion I am uncertain. Websites such as this are calling for MethyFolates while the trained MD is not accepting that idea. Any response would be greatly appreciated as with the struggles my daughter has had a healthy baby would be a blessing for her and her husband.

    Yours Sincerely, A Dad

  77. Vivian May 1, 2014 at 5:28 pm # Reply

    I have Hashimotos and only take iodine with my prenatal
    supplement. I see that your recommended prenatal uses
    Potassium iodide…is this superior over kelp? I’ve heard
    opinions on both sides.

  78. Paola May 2, 2014 at 2:30 pm # Reply

    Hi Dr. Ben!
    I’m 22 weeks pregnant with a lot of contractions, no infection in me apparently. I have IGM 14H and IGG 12H, also my report says that I have positive 1 copy of A1298C mutation and that I’m heterozygous for the A1298C mutation with negative (normal) for the C677T. This is my 6th pregnancy (1 baby born at 31.5 weeks, 1 baby born at 36 weeks, 3 miscarriages and this one, in that order). With my first daughter, I was with contractions since 16-18 weeks more or less going and returning. But at 31 weeks I started to have contractions every 3 minutes so I got hospitalized and at 31.5 weeks told me that the infection (they never really knew where it was) was now in the baby, so they made a C-section. Se born with bronchitis and other stuffs. Now she is perfect. With the second one, I started with contractions since 16-18 weeks too. At 28th week the contractions started stronger until 34th week that the doctor took me out of medication (Ventolin) and she born at 36 weeks super healthy. With this one, I’d had a cerclage at 15th week. At 18th week I started with contractions apparently I had an urination infection but at the end was negative, since that day I’ve been in bed rest and my contractions are still going. I’m taking since the beginning Aspirin Jr., Complex B, Vitamin D, Folic acid, Maternal vitamins, Heparin, Meticorten. And now the Orciprenaline (metaproterenol) to stop contractions and ciproxine as an antibiotic. Do you think this could be because of my A1298C mutation? Also I have Bradycardia with secondary syncope. Can I do something to prevent a pre term pregnancy this time?
    Thanks a lot!
    Best regards,

  79. Cheryl May 20, 2014 at 10:52 pm # Reply

    Hi Dr Ben!

    I am soooooo curious on what you have to say on treating morning sickness? You mention in the above podcast that you need to do a separate one on that topic. Have you done one? I can’t find anything on the topic on this site:( I’ve suffered badly with me pregnancies and would love some tricks to help improve quality of life while pregnant!

  80. K May 21, 2014 at 12:46 pm # Reply

    Hi Dr. Ben,

    Do you think the methyl B12 will mobilize mercury in pregnant women?


  81. Laura May 31, 2014 at 2:11 pm # Reply

    I am a bit confused about how much methylcobalmin to take while ttc/pregnant. I am homozygous 677t. I was previously taking Pure UltraNutrients, but I switched to your seeking health optimal prenatal. I noticed that the B12 is much less than what is typically recommended for MTHFR. Should I supplement with B12 in addition to your seeking health prenatal?

    I am also taking 7.5mg deplin and NAC, and green pastures fermented cod liver oil.

    Thanks for your help.

  82. Sandi June 26, 2014 at 5:47 am # Reply

    dr. ben,

    I am compound hetero and having trouble taking both the powder prenatal and the methylated b12 sublingual tablet. is it possible that i only need the prenatal and not the extra b12, too? I’m not sure how to pick between the two or divvy them up if it is important to take both. my doc has been suggesting both but even slowly working up to the dosages i eventually have terrible side effects with headaches and vomiting, and also weakness and fatigue for days leading up to the culmination of throwing up. not sure i can handle that much folate but want to make sure i am getting enough for a future pregnancy.



  83. Katrina Kost July 18, 2014 at 3:06 pm # Reply

    Hello Dr. Ben!

    I tested positive for C677T single mutation and A1298C was negative. I was also diagnosed with low progesterone and poor ovarian reserve. My OB recommended I take Foltx and a baby aspirin every day. I was told by a friend who also has MTHFR to not take this due to the high dose of folic acid. After much research, I realized that this was true. So, instead I have been taking 800MCG of Metafolin and a B-Complex vitamin daily. I’ve also limited my intake of folic acid, gluten, and sugar. I have severe endometriosis and had numerous miscarriages. I’m 34 years old and I do have a healthy 4 year old, but he did have a hole in his heart as an infant (not sure if this is related to MTHFR?). I did not know about MTHFR while pregnant with him. There is a good chance that I am pregnant right now, so I want to make sure I am taking the correct pre-natal and that my diet is correct. I’ve had a difficult time finding the right OB in my area and hope to find someone who is well educated in this area soon. I’ve been told that my body doesn’t absorb iron properly in the past, but never understood why. Could this be due to MTHFR? I just ordered Seeking Health Active B12 Lozenge With L-5-MTHF – 60 Lozenges. Would this be a good fit for me? If not, what would be? Do you recommend I see a Hematologist? Any help is greatly appreciated, I’m feeling a bit lost. Thanks so much!!!

  84. Becca July 19, 2014 at 8:47 pm # Reply

    Hi Dr. Ben –

    I’m currently 6 weeks pregnant and Compound Heterozygous. This is my first pregnancy after finding out I had MTHFR about a year and a half ago. I’m taking pretty much everything you’ve listed in this post/podcast with the exception of the prenatal vitamin and the prenatal powder. I am, however, using NuMedica’s Neuromethylation cream which contains the following:

    Natural vitamin D

    I’m very curious about your thoughts on this cream and whether or not Seeking Health will offer it in the future.

  85. Al July 21, 2014 at 9:21 pm # Reply

    This site reminds me of facebook. Everyone is asking questions and no one gets answered!

    • Dr Lynch July 30, 2014 at 4:34 am # Reply

      Al –

      There’s a ton of questions – I can only respond to so many.

      I do, however, respond more often now at – there is a forum there for members. I still do respond here – just not as much as I used to due to time limitations.

  86. Beth July 24, 2014 at 11:50 am # Reply

    Can you recommend a good prenatal multivitamin, given recently found out I am compound heterozygous and also have high copper:zinc ratio. From what I’ve researched, a lot of multivitamins contain copper, and only the Seeking Health Optimal Protein Powder doesn’t seem to. Are there any others out there, that aren’t as expensive? Without folate?
    This would be for TTC and during pregnancy. Do you also recommend continuing a prenatal multivitamin for the post natal period too?

  87. Becca July 27, 2014 at 12:19 pm # Reply

    Hi Dr. Ben –

    I posted back on July 19th but had few more things I wanted to add. Before finding out that I was compound heterozygous, I had two very healthy and uneventful pregnancies and both children were born extremely healthy. Pregnancies 3, 4 and 5 all resulted in miscarriage. Pregnancy three was lost at 12 weeks while 4 and 5 were lost around 5.5 weeks. I’m still a little confused as to how I had two healthy pregnancies and children and then all of a sudden three miscarriages. I’ve had the thought that the interventions I had with my first two (pitocin and epidural) and the anesthesia I received with the DNC after the 12 week miscarriage may be heavy contributors to somehow “triggering” the MTHFR and homocystinuria. Could this be true?

    As I said in the comment above, I’m currently pregnant and following your protocol with the exception of the prenatal (I’m taking the New Chapter prenatal.) After reading more comments and responses on the site, I’m concerned that I’m not taking baby aspirin or on Lovenox. With this pregnancy I’m seeing a midwife, not a regular OB. Should I start baby aspirin at this point? I’m 7 weeks along.

    Thank you for everything you do.

  88. Donna August 13, 2014 at 8:38 pm # Reply


    I was just diagnosed as compound heterozygous MTHFR after my third pregnancy ended (ectopic). We decided to test due to my past history (first child with major neurological birth defects, and second pregnancy ending in miscarriage). My physician has suggested that I go on baby aspirin until I get pregnant, as well as go ahead and start Enlyte for B vitamin supplementation.

    I have legitimately been diagnosed with Pernicious anemia 10 years ago (high gastrin level, increased stomach acid pH on EGD). I have been taking cyanocobalamin injections every 2 weeks for the last few years due to monthly injections not keeping my levels up. From what I’m reading, this may be due to the inactive form on B12 being used. I have found an active form (methylcobalamin injection), but it says it is not safe during pregnancy. I know that I need additional B12 supplementation, as it will not absorb in my GI tract. So, my question is this: Should I try a sublingual form of methylcobalamin in place of my monthly injections? My OB/GYN told me he had no idea……Any guidance is greatly appreciated! Thank you!

  89. Tiffany August 14, 2014 at 1:18 am # Reply

    I am trying to conceive. I just found out that I am homozygous C677t & I have endometriosis. What are the chances that I will conceive & have a healthy pregnancy? I am very worried & don’t know what I should do.

  90. Mellissa August 14, 2014 at 8:45 pm # Reply

    Hello Dr Ben. I have just recently tested positive for 1298AC and 677CT. My history with fetal losses has been 4 miscarriages, 1 tubal, 1 healthy child, 1 tubal, then another 2 miscarriages. All at 5 weeks or less. (This was all from age 28 to 31) I am 36 and we have been trying for the last 2 yrs to have another child without even a positive. As soon as I told my new dr, she had me checked for the MTHFR. She told me to go down to our health store and so this is what I am taking. TMG 1000 mg, 1 tab daily. Curcumin Phytosome 500 mg, 2 caps daily. B-Complex 50, 1 tab daily. However, this is what the owner said I should be taking. My Dr wrote that I should pick up CoQ10 and Tumeric. I didn’t because I trusted what the owner of the health store said. Should I be taking more? I also have a history of depression, which I take anti-depressants for and also severe migraines. Thank you for any advice you can give. Also thank you for this website! I had never heard of MTHFR before tuesday and this site has been a godsend for trying to understand!!

    • Lynn_M August 15, 2014 at 11:40 pm # Reply

      You have what’s referred to as a compound heterozygous MTHFR mutations. Turmeric and its extract curcumin are anti-inflammatory and CoQ10 assists with mitochondrial processes. These are good, but there are foundational supplements that are critical for people with MTHFR that are probably even more important for you. Those are methylcobalamin, the active form of B12, and L-5-MTHFR, the active form of folate. People with MTHFR mutations cannot convert folic acid and cyanocobalamin to the active forms of folate and methylcobalamin, and those inferior forms of folic acid and cyanocobalamin are probably what is in your B-Complex 50. If so, ditch the B-Complex 50, because folic acid and cyanocobalamin competetively inhibit the active forms of those vitamins that you require.

      Dr. Lynch is one of the preeminent doctors in the field of MTHFR treatment. I would follow the specific supplement recommendations he gives in this article. There’s much more to MTHFR treatment than just taking folate and methylcobalamin, you have to support your entire biochemistry. You also need to have a healthy lifestyle and attitudes.

      You might also check your husband’s MTHFR status, since he contributes half of the genes to a baby.

      • Mellissa August 16, 2014 at 12:01 am # Reply

        Thank you sooo much Lynn!!! Your right, checked the B-50 complex, ditched it. Did pick up the CoQ10 and a good prenatal that has folate and methylcobalamin along with DHA, EPA, and GLA. I ditched my regular multi-vitamin because it had folic acid. Some of the recommendations Dr Lynch has are a little out of my price range, so hopefully I’m on the right track for now?! Thanks again!!

        • Lynn_M August 16, 2014 at 1:58 am # Reply

          Because Vitamin B-12 is such a large molecule, only about 1% of methylcobalamin taken orally (from swallowing a pill) is absorbed. So don’t rely on your prenatal to supply sufficient methylcobalamin. You should take additional methylcobalamin in either sublingual, IM injection, subcutaneous injection, or in the topical oil form as found at

          Given that you don’t have time to waste in trying to get pregnant again, you might consider nutrient testing to ensure that your levels are optimal. Spectracell Micronutrient test is a good option, as is something like Genova’s NutrVal.

          • Mellissa August 16, 2014 at 2:28 am #

            Will get right on that! Thanks so much for your time Lynn!

  91. Meghan August 18, 2014 at 12:47 am # Reply

    Before I became pregnant with my daughter I was diagnosed with PCOS. My daughter is now 1 year old. I had no trouble conceiving what so ever (thank goodness) and I had a wonderful uneventful very healthy pregnancy and un-medicated natural child birth. After she was born all the issues started. extreme anxiety, depression, mood swings, easy bruising, hair loss, dry skin, achy joints, brittle nails, numb heels when sleeping, memory loss. My OB checked my thyroid hormones and thyroid antibodies and Dx me with Hashimoto’s and low vitamin D. After much research I started taking 150 mcg of Selenium, 175mcg of Iodine, a hebal thyroid support supplement, 4,000 IU of D3 drops, wide spectrum probiotic. I started seeing a holistic Dr. who checked my thyroid again after 5 wks on this regime and found my TSH lowered from a 7.2 to a 4.7, and both thyroid antibodies decreased TPO from 208 to 163 and thyroglobulin is now less than 1, Free T3 increased from 2.5 to a 2.7. She also checked for MTHFR because I’ve always had issues with insomnia, brain fog, lack of memory, mood issues, and just general feeling of being unhealthy even though I do everything right (so I feel) I am 29 now, but have juiced for over 10 years regularly, eat a diet of mainly organics and grow a lot of my own produce. Mainly organic meats. I am very active. I was told recently by my holistic Dr that I need to go gluten free, which I have been changing over slowly but not 100% there yet. The test came back homozygous for C677t which has led me to this site. So I have a few questions.

    1) My Holistic Dr. prescribed a whole new regime to see if my thyroid continues to get better and for the mthf and I want to know if all sounds okay as in amounts or interactions with each other?

    Morning Routine
    -Folapro: Methylfolate 800mcg (because I would like to conceive again)
    -PyhtoMulti: (2 capsule serving size) summary of B vitamins only) Niacin 50mg, B6 25mg, methylfolate 800mcg, methylcobalamin 200mcg, biotin500mcg
    -Ceralin Forte: (3 capsule serving size) Niacin 250mg, B6 25mg, methylfolate 500mcg, methylcobalamin 500mcg, Thiamin 30mg, Riboflavin 30mg, N-acetylcysteine 600mg, Acetyl-L-Canitine 600mg
    Thytrophin PMG: Bovine thyroid processed to remove thyroxine
    Vitamin-D3 drops 4000 IU

    -Thytrophin PMG: Bovine thyroid processed to remove thyroxine

    -OmegaGenics EPA-DHA 720: EPA: 860mg, DHA 580mg, other Omega-3 80mg
    -Standard Process Organically Bound Minerals: Iodine 225mcg, kelp 85mg, dried Alfalfa 275mg
    -Selenium 100mcg

    2) Is it best to take all the B vitamins at once like how I was prescribed to take them all in the morning, or should I be taking small amounts throughout the day?

    3) Is there a relationship between PCOS and mthfr? Hashimoto’s and mthfr? I don’t understand why I have so many hormonal issues!

  92. JulieK September 10, 2014 at 1:53 pm # Reply

    Hi –
    I’ve been diagnosed recently as hetero c677t. I recently had 2 miscarriages (blighted ovum and at 6 weeks) in the past 5 months. I do have a healthy 2 yr old girl after I had an early miscarriage back in 2010. My dr. just prescribed me folbic, but said it was not necessary. I’m 35 and trying to conceive again with a healthy baby. I was taking new chapter organics prenatal, but got my script filled. Should I reconsider taking folbic and take something else? Thanks.

    • Dr Lynch September 11, 2014 at 6:50 am # Reply

      You do not want Folbic. You need a quality prenatal and follow additional recommendations in this article.

      • JulieK September 11, 2014 at 5:48 pm # Reply

        Is the dosage in folbic too high? Or is that I cannot metabolize it therefore it could be either useless or toxic? Also, should my husband get tested for MTHFR too?

  93. layan September 14, 2014 at 5:45 pm # Reply

    hi dr
    I am from egypt , no doctors in my country aware of mthfr mutation , i am homozygous mthfr c667t iam 27 and suffred from 3 chemical pregnencies i want to know which is the best for me ( optimal prenatal or active b12 with L-5-MTHF or homocystex ) and what is the recomended does if i tolareted ?

  94. Carrie September 15, 2014 at 1:50 pm # Reply

    In april I found out for the first time I tested positive for 2 copies of A1298C mutation. Homozygous for A1298c mutation and negative(normal) for C677T. I have a healthy 6 year old, my internist said it was a miracle. I didn’t know then I had the mutation. I had a miscarriage in 2011 – blighted ovum, and have been sexually active since then. I just found out I’m pregnant. I believe it’s because of the supplements my internist has me on. I’ll be 44 when the baby is born. What supplements should I be taking? I don’t see my ob/gyn til Friday and honestly I don’t think he’s up to par on the MTHFR mutation. I don’t want to wait until my ultrasound on Friday to begin supplements.

    Also, my internist has me on ProbioMaxDailyDF, Biotis: IPS, Vitamin D3(10,000 iu), copper, DHEA (5mg), 1/2 iodine tablet, zinc 15, gastrazyme and l-Carnitine. I also occasionally take a samE supplement. I also take a liquid multi that does not contain folic acid.

    After some research, I’ve been taking one bayer aspirin in the morning since i took the pregnancy test.

    Should i continue with these supplements? What prenatal should I take? Please advise! Thanks!

  95. jodi October 5, 2014 at 2:03 am # Reply

    Supplements for males, aid pre conception?

  96. Anita October 9, 2014 at 1:10 am # Reply

    I recently purchased the prenatal vitamins but when do I take the pills if I also take a thyroid pill (hypo). Since I don’t want it to interfere with the absorption of the prenatal pill. How many hours apart.

  97. Tanya November 7, 2014 at 11:07 pm # Reply

    Hi, Can anyone tell me if overmethylation is dangerous during pregnancy? I had six miscarriages before having my amazing boy. I would like to give him a sibling and feel I need to increase the amount of methylfolate I was taking. My amazing little man was born with a sacral dimple (benign, but related to spina bifida) and tongue tie – he is fine, (better than fine, he is sensational – does not sleep well at all, but sensational!) but I think these are indicators of not enough methylfolate. My issue is, I have increased my intake of methylfolate while still taking b12 and other recommended suppliments and I am feeling the effects of overmethylation (along with being tired due to my little man not sleeping well). I am older in age, so I can not wait to start trying again, I am already on borrowed time due to my miscarriages. I know I have a comt, plus other genes not great for using folate and oestrogen… so I am asking if the overmethylation causes probs ? does it increase the chances of blood clotting or any other side effect that would be harmful if pregnant. Sorry for any errors in writing this, my little man keeps hitting the keypad. Kind regards Tanya

  98. Katie November 7, 2014 at 11:42 pm # Reply

    I see this list showing Prenatals that are iron-free but I click on the link and the supplements have iron. We REALLY need an iron-free one ASAP.

    “Optimal Prenatal: provides 800 mcg of methylfolate and folinic acid for best folate support. Using only methylfolate in a prenatal is not recommended. This is iron-free.

    “Chewable Optimal Multivitamin: this has no iron, has a nice taste and requires a woman to take additional methylfolate during pregnancy and breastfeeding.”

  99. Kelly November 9, 2014 at 12:14 am # Reply

    Dr. Lynch,

    My husband and I are trying to conceive after several miscarriages. I am hetero for 1298c and my doc (who has been to your training) has me on a compounded supplement of the following:
    Methyl B12: 2 mg
    L-MTHF: 7.5 MG
    P5P: 25 MG
    ZINC: 10 MG
    MAG: 40MG
    NAC: 400 MG
    D3: 2500

    My question is, is this formulation fine to take once pregnant? I would switch to a prenatal once the pregnancy is confirmed, but for the few weeks that I would be pregnant and not know it yet, is this acceptable?
    Thank you!

    • Dr Lynch November 9, 2014 at 11:40 am # Reply

      Kelly –

      It is pretty high methylfolate but if you feel good with it – then ok.

      The magnesium amount is quite low – 40 mg? or 400 mg? what form?

      Rest of formula is fine and safe.

      I personally recommend people to take a prenatal prior to getting pregnant.

      One needs a comprehensive nutritional plan prior to getting pregnant – both man and woman.

      I do wholly recommend the Optimal Prenatal Protein Powder as it is extremely comprehensive – and easy to use – and tastes great as well. Disclosure – my company.

      Both you and your husband should use this. The quality of sperm is also very important for the unborn child’s health and genetics.

      • Kelly November 10, 2014 at 4:50 am # Reply

        Thank you for the quick and informative response! I am going to order the prenatal powder.
        I feel great on the 7.5 MG. I was worried about negative side effects, but haven’t had any.
        I believe the magnesium is 40mg. I am not sure why so low.
        I have been on this formulation for many months and my husband has also been on supplements (based on his blood work, needs, etc).
        I planned to take a prenatal as well as my above formula, however, I was afraid of getting too much of the Bs.
        Can I take the prenatal powder along with my current regimen?
        Once pregnant, is the above formulation too high to continue?
        Thank you for help, Dr. Lynch!


      • Kelly November 10, 2014 at 4:54 am # Reply

        Oh, and I forgot to add, the magnesium is glycerinate. Thanks!


        • Kelly November 10, 2014 at 4:56 am # Reply

          Oh, and I forgot to add, the magnesium is glycinate.

  100. Rose November 13, 2014 at 1:52 am # Reply

    Hi Dr Ben, PLEASE I AM DESPERATE NEED OF HELP FOR MY SISTER WHO HAS JUST HAD HER 11th MISCARRIAGE. She has not tried to get pregnant in over a year, cleansed her body, gluten free dairy free. She has been taking the supplements of Metformin 1500 mg, Metanx, Vitamin neevo prenatal,vitamin B6 B12 in all active form, and an aspirin before being pregnant. Doctor put her on lovenox 1 time a day this pregnacy. NO ONE IN NEW YORK KNOWS ABOUT THE MTHFR GENES. She was put on cynthroid 100mg to keep TSH DOWN BUT DOES NOT HAVE A THYROID PROBLEM. I will give you a history of both my sister and brother in law and I ask PLEASE give us some advice.
    My sister has a history of ANA POSITIVE. HOMOZYGOUS FOR C677T with normal homocysteine levels. 2 copies of the 4g allele in PA1. Positive anti annexing.

    My brother in law is heterozygous for 1 copy of c677t, 1 copy A1298c and Hetero for G20210 in the prothrombin factor, 2 gene at elevated risk for venous thrombosis, positive for 2 copies of 4g variant and is homozygous 1. This is what we have from doctors results. Please if you have any advice please help us if they will be ever to have a child together with all these MTHFR GENES. Thank you in advance.

  101. Rafaela November 21, 2014 at 11:59 pm # Reply

    Hi Dr. Lynch,

    I am Homozygous for C677T and found this out 6 months ago after trying for a baby for 5 yrs with no pregnancy.

    I stopped taking folic acid immediately once I found out and take now:
    1 tablet of your product HomocysteX Plus and 1000 mcg Folate as Metafolin in addition.
    Yesterday I had an embryo transfer as part of my 2nd IVF cycle (also had 3 rounds of IUI).

    My supplements give me a total of 1800 mcg of folate a day however given I am homozygous is that enough? From previous blogs I read to also take 3000 mcg Folinic Acid which I will order but shall I take that instead of the additional 1mcg of Metafolin and just stick with the 800 mcg of Folate in the HomocysteX??

    Also once question which I am confused about and can’t seem to find in your article:
    The article seems to be a general article for anyone pregnant but does not give suggestions for Homozygous people specifically like your Basic Protocol.
    Or am I supposed to combine your Basic Protocol and the Prenatal suggestions?
    Your Optimal Prenatal Vanilla mix which I also ordered only contains 800 mcg of folate and folinic acid. Surely that’s not enough for someone Homozygous like myself?
    I know you don’t like to give suggestions on amounts to take but an estimate would be great.

    Thanks very much,

  102. sandi December 5, 2014 at 5:55 am # Reply

    Dr. Lynch,

    It seems like every time I try to take your prenatal, whether I gradually work up to the dose or not, I get headaches for several days at some point and then eventually am also throwing up all night.

    I am compound hetero and have been working with an ND to clear a sulfur pathway first and it still didn’t work. Do you have other recommendations for meeting my folate needs for a healthy pregnancy with this mutation? Are some people just unable to tolerate folate or b12 in certain forms? For awhile, I seemed to be ok with hydroxo b12 and L5MTFH but I’m having trouble replacing the L5MTHF with your prenatal. I am afraid I messed it up somehow and now I will not be able to tolerate even what I was doing before (hydroxo b12 and L5MTHF). Would love help – I have been trying to work this out for nearly a year now before trying to conceive in order to try to avoid having miscarriages again.

    • Dr Lynch December 5, 2014 at 7:29 pm # Reply

      Sandi –

      Sorry to hear that. Are you trying the Optimal Prenatal Protein Powder or the Optimal Prenatal capsules?

      First thought is your digestive system needs support. Please work with your doctor on that.

      Also read this article:

      • sandi December 6, 2014 at 2:22 am # Reply

        Dr Lynch,

        Thanks for getting back to me. I have only tried the powder. Do you think the capsules would be any different? The folate that I tolerated well before was in capsule form.

        I have been on probiotics and am finishing a candida diet. Cut out wheat and dairy is limited. What other digestive support is there?

        Thanks for the article link. I passed it on to my ND. At some earlier point she did have concerns about glutathione with my sulfur pathway that she is trying to clear.

        I am also breastfeeding which makes it more complicated and harder to know what I can and can’t take. Do you know if your preventive measures are breastfeeding and pregnancy friendly? (glutathione, electrolyes, adrenal cortex)

        Thanks for all of the work that you do on this.

  103. Jessica December 15, 2014 at 8:30 pm # Reply

    Hi there!

    I am so confused! I just found out I’m pregnant, 6 weeks, and I’m not sure what I should be taking! I’m homozygous for c677 and Herero for factor v.

    I just ordered the optimal prenatal pills, what else should I be taking? My dr just gave me folgard but after reading this I don’t want to take it anymore.


  104. Claire December 16, 2014 at 11:27 pm # Reply

    Is it not possible to get enough natural folate eating liver weekly and leafy greens daily?
    I am worried if I take the prenatal I will be overdosing on things like Vitamin A perhaps, since I eat liver each week and take cod liver oil.

    • Dr Lynch December 18, 2014 at 6:21 am # Reply

      It can be possible to get enough folate from liver and leafy greens – definitely. Need to check your RBC folate levels and MCV and MCH.

      Vitamin A can be deficient in many pregnant women – and it is. The vitamin A in Optimal Prenatal is a 50/50 blend of beta carotene and retinyl palmitate -so it is not all vitamin A – only 50% of it is.

      You could also switch from cod liver oil to just regular fish oil.

      • Claire December 18, 2014 at 12:36 pm # Reply

        Thanks Dr Lynch for your reply. I will try get those levels checked privately. My GP only tested serum folate and it is very elevated. She didn’t know why. But I’ve had it elevated even in previous tests when pregant (and taking folic acid) and when not pregnant (and not taking folic acid). Any idea why this could be?

        With my 4th pregnancy I started taking methylfolate later on but did end with miscarriage (despite 3 normal previous births). I think it was due to a chronic gut infection I’ve since discovered and a stressful year. This year I have developed anxiety type symptoms and am trying to figure out what is going wrong so I can have another healthy baby. I sometimes get a tight chest and can’t fgure out what is causing it. Any tips what else to test for?
        Thanks for your great informative website.

      • Claire January 20, 2015 at 10:40 pm # Reply

        Hi Dr Lynch, Just wondering how much natural food form folate would you recommend would generally be enough to eat. e.g. one liver meal per week plus some sides of cooked leafy greens few times per week? (I get worried about eating too much raw leafy greens with all the stuff I’ve read on oxalates which I am suspecting may be an issue for me).
        I am assuming if someone has certain MTHFR genes then one would need extra folate? (I have yet to test myself)
        I just tend to feel that no matter how good a supplement is, the body deals with food sources much better and I would prefer to get as much nutrition from food before opting for supplements. And probably more risk of over doing it with supplements than there is with over eating food folate?
        I would appreciate your thoughts on how to get enough food form folate.

  105. Tsvety December 17, 2014 at 8:05 pm # Reply

    Hello, d-r Ben!
    My name is Tsvety, I am 32, from Bulgaria.
    I have been diagnosed with MTHFR C677T homozygous mutation, after i had to cease pregnancy in 21 week, beacuse of several malformation in the baby Now, two years later I am planning again to try … Unfortunatelly we don`t have good spacialists here in Bulgaria and I am trying to educate myself through the internet. I hope I will find the answers of my questions here. I have one more missed abortion in 9 week last year (I don`t know if it has any relation with MTHFR). Now will be my third trial…. The main problem is that after the diagnosis became clear I was prescribed by the so called genetic specialist to take 3×1 Neofolic Meta + 2 x 1 B complex (normal). After a year we increased the dose to 3×2 Neofolic Meta. Recently I have understood that people like us are absolutely forbidden to take normal forms of these B-vits :(((((

    Now I am searching for answers and fighting by myself. My question is what do you think about this specific product and if I start taking it now, do I have to continue taking it through my pregnancy and through the breast-feeding (with God`s help) ?

    Many thanks in advance, I am really counting on you to help me …

    • Dr Lynch January 13, 2015 at 3:14 am # Reply

      Hi there –

      I am not sure about Swanson products. I know they are quite inexpensive but not sure of their potency or delivery/absorption.

      The article above outlines what I believe to be most supportive.

      • Tsvety January 13, 2015 at 8:42 am # Reply

        Hello, d-r Lynch :)

        Thank you very much for getting back to me.

        I have already ordered the Swanson`s active B complex, because I didn`t know what to do :( Is there a way to track the effect ? How am I supposed to understand is this product reflecting positive on me, or negative ?

        I wanted to ask you in addition one more question. In Bulgaria all the specialists recommend the methyl form of B9 + B complex (normal synthetic formula). Is it ok for us to take the normal form of B complex, not active ??? is it harmful ?
        Something else is a therapy with fraxiparine injections while being pregnant. But I stil cannot understand in which cases this therapy is needed ? Me presonally, nobody prescribed fraxiparine ….

        Thank you in advance !

  106. lauryn January 3, 2015 at 1:23 pm # Reply

    Hi Dr lynch,
    Does Garden of life provide the correct folate form for MTHFR? It says it is folate from organic lemon. Does this get absorbed as easy as the L5MTH? i have been taking the Garden of life and the Jarrow b-right. What do you think?

    Thank you so much for all of this wonderful information!


    • Dr Lynch January 4, 2015 at 9:11 pm # Reply

      Hi Lauren –

      I am not sure – I demand understanding exactly which form of folate is used in the supplement and I believe all consumers should be educated to do the same. This is why I clearly label all of my formulations which precise ingredient type. I never just use ‘folate’ – but rather ‘Folate (as Quatrefolic and calcium folinate)’ for example. This way you know you are getting two active forms of folate – and exactly which ones. These are the two that I use in Optimal Prenatal – as mentioned in the article above.

  107. Lauren January 6, 2015 at 12:50 am # Reply

    Hi Dr. Lynch,

    I’m compound heterozygous and am 24 weeks pregnant. I’m currently taking Seeking Health Optimal Prenantal , Seeking Health Optimal Fish Oil, Seeking Health Active B12, in additional to PB8 probiotics and Calm (magnesium).

    Is it safe to also take Glutathione or NAC while pregnant to aid in detoxing my body?


    • Dr Lynch January 9, 2015 at 9:09 am # Reply

      Hi Lauren –

      I would not take NAC or glutathione while pregnant. You do not want to actively detox while pregnant. The best thing to do is avoid exposures – that’s the ideal way to detox while pregnant ;)

  108. lauryn January 8, 2015 at 8:34 pm # Reply

    Hi Dr. Lynch-
    Is it ok to take your vitamin E during first trimester? I have been reading studies online linking Vitamin E (400iu+) with birth defects. Is there truth to this? If not, how many of the Vitamin E 400 should I be taking and when should I start?

    Thank you for all your generous help!!

  109. Claudia January 9, 2015 at 3:27 am # Reply

    Dr. Lynch,

    I have had 7 implantation failures with c677, leiden factor v and endometriosis while taking Lovenox and NeevoDHA. I have been working on healing leaky gut with GAPS protocol for last six months and implementing your protocols. But, I can only tolerate up to 200 mcgs of L-5-Methyltetrahydrofolate and hydroxocobalamin. Any more methylfolate and methyl B-12 and I get terrible joint pain, depression, etc. I am taking your B-minus supplement and will start on calcium d gluconate to be able then to take glutathione, as per your article. Is there something different about the form of L -Methylfolate in NeevoDHA that makes it more tolerable? I didn’t have any side effects with that form. Also, I can take folinic acid with no side effects.

    Thank you for your great website and all the supplements from Seeking Health!

  110. Niki January 14, 2015 at 1:56 am # Reply

    Hi Dr. Ben,
    I’m 29 yrs old and have been dealing with rpl for 13 years. I’ve had 6 miscarriages all at the same time of 6 weeks and had one live birth but she had IUGR and died 8 days later. I just found out in May after my last loss that I have heterozygous c677t and the doctor said that had nothing to do with my many losses. Anyway, with my last 2 pregnancies they tried heparin thinking I had a bleeding disorder but didn’t know what, and that didn’t work. The second time, they doubled my heparin and that still didn’t work. And there was another time they tried progesterone and that didn’t have any impact. I do know that whenever I get pregnant, all my numbers:hcg, progesterone etc, all look great and then BAM! Instant death almost. Wth is going on? Is just heparin not enough? I know now what I have, so I can take the right vit, but I’m quite terrified. Just moved to another state cause I have NO trust in the other state I was living in. I can’t handle losing another baby, burying one was hard enough. Please, please give me some insite.

  111. Elizabeth January 14, 2015 at 9:16 pm # Reply

    Hi. I am homozygous C677T and plan to get pregnant soon. I want to make sure I have this clear: You recommend to take the Optimal Prenantal with the addition of Sublingual Active B12 with Methylfolate AND L-5-MTHF?

    Also, the Optimal prenatal has CoQH in it already. You want us to add more in addition to that?

    I am confused as to why you suggest taking the chewable cal/mad plus D, Optimal vitamin E, and Optimal PC. Can you please explain? Thank you

  112. christieann mathison January 17, 2015 at 4:10 am # Reply

    Hi Dr Lynch. is there ANY direction or input you can offer on PUPPP’s(Pruritic urticarial papules and plaques of pregnancy) and possible mutations or snp’s involved and how to correct or protocol once they erupt in pregnancy?
    I have my family’s 23andme data, I had PUPPPS with my son, not my daughter and he also had breastMILK jaundice(late onset 8 weeks -5mths)…..any input would be appreciated.
    I am homo MTHFR C677T, MAO-AR297R, BHMT-08
    he is homo MAO-AAR297R, VDR TAQ, MTRRA66G, BHMT-08 & hetero MTHFR C677T

    • Dr Lynch January 17, 2015 at 8:17 am # Reply

      I’d look at histamine – and reduce histamine containing foods – and support your pregnancy more nutritionally.

      Pregnancy requires a lot of nutrition and methylation – and reduction in either can increase histamine.

      Histamine can increase urticaria.

      I believe if you support with the recommendations above and reduce histamine containing foods – you’ll reduce your risk of this stuff.

      Read this about histamine:

  113. Zori January 20, 2015 at 8:33 pm # Reply

    Hello, D-r Ben,
    I am 26, with diagnosed endometriosis and one missed abortion in the 10th gestational week.
    I tested homozygous MTHFR 677CT and heterozygous MTRR 66AG after the abortion. My homocysteine levels are normal.
    I want to have a successful pregnancy so much! Please, give me your advice!
    I am also heterozygous 4G/5G for PAI and heterozygous for Val34Leu (F13).

    After the missed abortion, I have been taking l-methylfolate for already 9 months. In the 8th month I added active b 12 (of ‘Seeking health’, 5000 mcg lozenges as methylcobalamin and adenosylcobalamin) and I also took one tablet of ‘B minus” (of “Seeking Health”) everyday. First, I started with 1/8 of b 12 lozenge, and then gradually reached 1/4 of b 12 lozenge. When I reached ½ ot b 12 lozenge I had terrible HEADACHE and stopped B12 and B minus and continued with l-methylfolate. After one week I tried again with 1/4 of b 12 lozenge every day but the same headache appeared. Do I have to immediately consult a doctor?!?
    I am taking now birth control pills to control ovarian cysts, but I have never had such a reaction to them, so I suppose reaction is to b12.
    – Do you think all that means that I have enough b 12 in my body and I do not need to take it in an active methylated form?
    – Should I supplement with b 12 and b complex in any way? Do you think I should switch to only adenosylcobalamin or only hydroxocobalamin during pregnancy? IS HYDROXOCOBALAMIN PROPER or IS IT TOXIC (as ciancobalamin) FOR PEOPLE WHO ARE HOMOZYGOUS MTHFR 677CT and HETEROZYGOUS MTRR 66AG? What dosage do you recommend during pregnancy, having in mind my headaches?
    – Should I take b1, b6 and the other b vitamins in an active form or I can use the not active ones?
    Thank you so much in advance! I am glad that you exist!

  114. Lola January 29, 2015 at 11:13 pm # Reply

    Dear DR. Ben

    I had miscarriage 6 moths ago and got tested for gene mutations. I am MTHFR C667T heterozygotus and i have also other mutation PAI-1 heterozygotus 4G/5G
    According to my OB/GYN he suggest that i need to be under low molecular heparine next time i get preagnant , for blood thining also he recommends high dosage of folic acid…wich i wont take. I am already taking 400 mcg metafolin and 1000 mcg of methyilcobalamin. I am also taking 2000 mg of omega 3 premium fish oil and probiotics (l-bifidus).
    I have kidney stones and often acid reflux with heartburn wich are mainly treated with antacids.
    I’m trying to make some supplement plan that will collerate with all my conditions and prepare my body for next hopefully healthy pregnancy.
    what do you recommend? wich supplements and what about vitamin D3 and my kindey stone conditions? taking b12 on empty stomach in the morning really worsen my heartburn wich conserns me. I have a feeling that i am taking too many pills and that they dont work well all together.

    Thank you in advance,


  115. Domonique January 30, 2015 at 12:16 am # Reply

    Hi Dr Ben, firstly thank you. I’m a big fan of your work and appreciate your time in explaining this all important topic…

    Just wanted to ask re: prenatal supplementation for healthy women that don’t have MTHFR snip/s. Would you still recommend the same, being: Muliti, CoQH, probiotic, Active B12 w/ MTHF, Optimal Krill Oil & Fish Oil, Vit D360 and CalMag?

    Also, what’s your thoughts on supplementing with Fermented Cod Liver oil instead of Fish Oil?

    Thanks in advance!

    • Dr Lynch January 30, 2015 at 8:08 am # Reply

      Hi Domonique –

      I would recommend the same yes – because a lack of a SNP doesn’t mean a lack of function in the enzyme – other issues may be present – such as nutrient deficiency for one.

      I do not recommend fermented cod liver oil – high histamine. High histamine = bad for pregnancy and for those with DAO snps or gut issues.

      • Domonique February 16, 2015 at 3:26 am # Reply

        Thanks so much Dr Lynch, really appreciate it!

  116. Lucinda February 5, 2015 at 4:35 am # Reply

    Hi Dr Ben,
    Thanks for everything you do! I have one copy of the MTHFR 677CT and many other SNPs and am hoping to fall pregnant in the coming months. I have purchased the following and am wondering if I can take them all ‘together’ or if there is overlap with any and therefore no need to take them?
    Optimal Prenatal Protein Powder
    Active CoQH
    Optimal Vit D Liquid
    Chewable Cal/Mag plus D
    Probiota 12 Powder
    Optimal Vit E
    Optimal Fish OIl
    Optimal Krill Oil
    Optimal PC.

    Thanks in advance.

    • Dr Lynch February 5, 2015 at 8:32 am # Reply

      Hi Lucy –

      Morning smoothie with 1/2 scoop of Optimal Prenatal Protein Powder
      With smoothie, you can take 1 capsule of Optimal PC and Optimal Fish Oil

      Lunch smoothie with the other 1/2 scoop of Optimal Prenatal Protein Powder

      OR you can the whole scoop in the AM if you feel better that way. That is what many do – it’s up to the person.

      Lunch: 1 Active CoQH and 1 Optimal Krill Oil

      After dinner: 1 Chewable Cal Mag Plus D (or you can take this anytime – midday – anytime – just spacing it out here as it fits.

      After dinner: ProBiota 12 Powder – 1/4 scoop

      Optimal Vitamin D – 21 drops once a week should be good to go. Or you can do 3 drops a day – anytime with or without food.

      I would return the Optimal Vitamin E as it is already in the Optimal Prenatal Protein Powder- unless you have clotting issues – then you may need more but typically what is in the prenatal protein powder is enough.

      Keep in mind that your partner should also be supporting his nutrition. He can also take the Optimal Prenatal Protein Powder (I do).

      He should take what you take. Healthy sperm is also very important.

  117. leah February 5, 2015 at 10:38 pm # Reply

    So can children take l methyl supplements and if so at what age?

  118. Zori February 8, 2015 at 10:36 am # Reply

    Hello again, D-r Ben, is hydroxocobalamin proper or is it toxic (as ciancobalamin) for people who are homozygous MTHFR 667CT and heterozygous MTRR 66AG and can they actually absorb it?

    Thank you.

    • Dr Lynch February 9, 2015 at 8:14 am # Reply

      Zori –

      Hydroxocobalamin is useful for those who have excessive nitric oxide – this is complex to identify.

      It has to be methylated to methylcobalamin – so those who have too many methyl groups floating around, it could help with that – but it also helps with hydrogen sulfide excess and nitric oxide excess.

  119. Claire February 15, 2015 at 8:02 pm # Reply

    Hi Dr Lynch,
    I’ve just noticed you have updated this prenatal article but it seems more concise in terms of the supplements described to take in pregnancy. Is it possible to have your more detailed list I’m sure I saw before?
    Many thanks

    • Dr Lynch February 16, 2015 at 2:51 am # Reply

      Claire –

      The list for detailed supplementation is above. I edited it a bit as many of the nutrients were already in the Optimal Prenatal and I didn’t want people to take more than needed.

      The original list was before I formulated Optimal Prenatal.

  120. Zori February 16, 2015 at 5:45 pm # Reply

    Thank you d-r Ben! I have terrible headache from methylcobalamin and adenosylcobalamin, so I can’t take them. I am homozygous MTHFR 667CT and heterozygous MTRR 66AG, so is it safe for me to take hydroxocobalamin and will I absorb it?

    • Dr Lynch February 16, 2015 at 7:41 pm # Reply

      Hi Zori –

      Please read this article – and you likely need to do these steps first:

      Then you should be able to tolerate the methyl/adenoB12 combination.

      • Zori March 25, 2015 at 7:36 pm # Reply

        Thank you D-r Ben, I am trying to follow these steps. After I added l-gluthatione I received again a slight headache but it is bearable. My potassium levels are normal (4.81 mmol/l with reference range – 3.5 – 5.5) so I don’t take any potassium. I am taking now little quantity of b 12 of Seeking health and l-methylfolate. Can people wirh MTHFR C677T Homozygous Mutation absorb vitamin B 6 in the form of pyridoxine hidrochloride and is it harmful for us in this form ?

  121. Tanya Chilts February 17, 2015 at 1:36 am # Reply

    Hi all in Australia. If you are looking for a supplier of Seeking Health products in Australia (I was) go to Realize Health .I have placed two orders with them, their delivery time was good and Aus dollar conversion pricing very comparable. I was very happy with them. Thought I would share as I want them to keep stocking Seeking Health!

    • Domonique February 17, 2015 at 3:03 am # Reply

      Hi Tanya, I’m in AUS & bought direct off Seeking Health – they ship worldwide. It only took about 7days to arrive and conversion is just based on exchange rate..

  122. Domonique February 17, 2015 at 3:07 am # Reply

    Hi Tanya, I’m in AUS and I just bought direct of Seeking Health – they ship worldwide. It only took about 7days (and that’s to Darwin) to arrive and the conversion was based on current exchange rates…

  123. Kat February 19, 2015 at 3:08 am # Reply

    Hello Dr. Ben,

    I just found that I have the c677t heterozygous mutation after having a miscarriage. I also have hypothyroid (mostly well regulated) and hashimotos. I am on second bottle of your prenatal vitamins, as well as probiotic and epa/dha from metagenics.

    I will going for an embryo transfer probably in next month to 6 weeks and would like your opinion on anything else I should add to optimize chances for a healthy full term pregnancy and healthy baby.

    Thank you for all the important work and information you are putting out there, this is quite overwhelming, and finding your website has been terrific.


  124. Ashley March 6, 2015 at 7:52 pm # Reply

    Hi Dr. Ben,

    I just delivered twins, and I’m planning on having them tested for mutations. I have heterozygous 677T/1298C MTHFR mutations. My question is- if my twins also have these mutations, how would we treat them? They are almost 6 months old.

    Thank you!

  125. Breann March 8, 2015 at 9:45 pm # Reply

    Hi Dr. Ben, thank you for this article!

    My son was born with a cleft lip. I am ordering your products now to use while breastfeeding.

    I just discovered I am hetero MTHFR C677T (as well as homo MTRR). My b12 came back at 1439…. I am just wondering with a high b12 if I should follow the recommendations for Prenatal Supplementation?

  126. lemley March 9, 2015 at 4:34 am # Reply

    I HAD A MISCARRIAGE IN 2000 AND I HAVE BEEN TRYING EVER SINCE. I HAD SURGERY IN 2007 TO REMOVE THE fibriods and they came back again. until i met oduduwa ajakaye in 2014 who send me his herbal product, today im cured and have given birth

  127. Vee March 9, 2015 at 8:42 pm # Reply

    Had to take neevo dha and an asprin a day during my 2nd pregnancy. I have just found out I am pregnant again and want something more wholesome such as your products. I do not have MTHFR, my miscarriages where just marked down as unknown causes.
    Which products do you recommend I take?


    • Dr Lynch March 11, 2015 at 5:39 pm # Reply

      Vee –

      Regardless of SNPs or lack of MTHFR, the suggested prenatal protocol above is needed to support overall healthy development of a baby.

      I would talk with your doctor which ones are best for you.

      At the very least, I recommend:
      – Optimal Prenatal – either capsules or powder but I am way more pro-powder as it is super easy and complete with protein as well
      – Optimal PC capsules
      – ProBiota 12
      – Optimal Fish Oil
      – Optimal Vitamin D Drops

      To support your understanding of what goes on with pregnancy and how to optimize methylation during this amazing time, I passionately recommend the Prenatal Conference course. It’s very useful for your physician(s) as well.

  128. ruth March 16, 2015 at 10:48 pm # Reply


    I have had 4 healthy children and after I had 5 miscarriages all normal chromosomes. All miscarriages occurred at 10 weeks and I know that’s when the placenta takes over. I’m now pregnant again and had lots of testing done and the only thing that came up is that i’m heterozygous for both c677t and 1298c with normal homocystein levels. Currently i’m taking baby asprin, lovenox, neevodha, vit D3, progesterone. They say i’m a special case especially since I’ve had 4 healthy children. i’m not sure what’s caused my miscarriages. Please let me know what I can do to better my pregnancy. I don’t want to lose another baby. Thanks!

    • Dr Lynch March 21, 2015 at 5:00 am # Reply

      Ruth –

      A normal homocysteine doesn’t mean much – need to evaluate SAM:SAH.

      I highly recommend you and your physicians watch this pregnancy conference recording:

      NeevoDHA is not the most complete prenatal in my opinion. Do consider a more complete one – there are some recommendations above –

      Fish oil may be needed – check for clotting disorders and hormone panels.

  129. Cara March 22, 2015 at 1:30 pm # Reply

    Hi Dr Lynch
    I have been diagnosed with compound hetero after 2 miscarriages. I have bought your optimal prenatal vitamins and have been taking 6/day along with active B12 with L-5-MTHF. I have been taking 1 lozenge before breakfast and lunch. Do you think that’s enough methylfolate? Also my obgyn says I don’t need to take aspirin. Do you suggest a baby aspirin daily? I am also taking vit d3 4000iu. What other nutrients should I be taking? Thank you so much for your time.

  130. Tsvety March 22, 2015 at 8:13 pm # Reply

    Hello, d-r Lynch

    Since it is too hard too order Seeking health in my country, I am trying to find some substitutes and relevant supplements. Please share your opinion on this product, which I can find in our pharmacy shops in Europe –

    What is this form of folat and is it dangerous for us –

    Folic Acid 400 µg 200
    Amount provided by:
    L-Methylfolate 200 µg
    Pteroylmonoglutamic Acid 200 µg

    I bought also Melatonin, Prim rose oil, Q 10 and Alpha-lipoic acid.
    Is this enough ?
    This is the whole content, :

    Nutritional Information Average per 2 tablets % EC NRV*
    N-Acetyl Cysteine 50 mg –
    L-Arginine 100 mg –
    Inositol 100 mg –
    Natural Mixed Carotenoids 2 mg –
    Vitamin D (as D3 400 IU) 10 µg 200
    Vitamin E 4 mg α-TE 33
    Vitamin K 70 µg 93
    Vitamin C 80 mg 100
    Vitamin B1 (Thiamin) 5 mg 455
    Vitamin B2 (Riboflavin) 2 mg 143
    Vitamin B3 (Niacin) 20 mg NE 125
    Vitamin B6 10 mg 714
    Folic Acid 400 µg 200
    Amount provided by:
    L-Methylfolate 200 µg
    Pteroylmonoglutamic Acid 200 µg
    Vitamin B12 9 µg 360
    Biotin 150 µg 300
    Pantothenic Acid 6 mg 100
    Calcium 500 mg 63
    Magnesium 150 mg 40
    Iron 17 mg 121
    Zinc 15 mg 150
    Copper 1000 µg 100
    Manganese 0.5 mg 25
    Selenium 55 µg 100
    Iodine 140 µg 93
    NRV = Nutrient Reference Values, µg = microgram
    mg = milligram, IU = International Units.

    Two Pregnacare® Max Tablets per day, plus one Omega-3 capsule every day. Swallow each with a cold drink and take with a main meal. Not to be chewed. Do not exceed recommended intake. Pregnacare® tablets and capsules should only be taken on a full stomach. You can start taking Pregnacare® Max at any point during pregnancy.

    No artificial colours
    No preservatives
    No salt or yeast
    No lactose
    Gluten free
    Pregnacare® is not tested on animals
    Formulated by experts
    Slow disperse tablets – gentle on the stomach

    Omega-3 Fish Oil 600 mg –
    DHA (Docosahexaenoic acid) 300 mg –
    EPA (Eicosapentaenoic acid) 60 mg

  131. ally April 7, 2015 at 3:22 am # Reply

    Hi Dr. Lynch-
    Is it safe to begin methylcobalamin and methylfolate while breastfeeding? I’ve read this can Kickstart the methylation pathways and detoxing can occur, passing heavy metals and toxins into breastmilk? I’m homozygous c667t, and have been having neurological symptoms, muscle weakness and fatigue, brain fog, extreme fatigue for 4 months. Thank you!

  132. Marwa El-sayad April 13, 2015 at 12:54 pm # Reply

    hi dr
    im 34 yrs old …i am diagnosed as hetero c677t muation …im now 6 weeks pregnant ..i am on 1600mcg metafoline and 1000mcg methylcobalymaine …and my fasting homocystein level is 5…also i take asprin and innohep once daily
    i need if this dose of metafoline and vit b12 is enough or i need to increase the dose


  1. Read this First! | | MTHFR.NetMTHFR.Net - January 27, 2012

    […] Prenatal Supplementation with MTHFR […]

  2. Using Personal Experiences as Part of Research. | Scientific Mamma - July 15, 2013

    […] miscarriages. Many of these women have another thing in common. They are trying to follow the protocol Dr. Lynch lays out on The link will take you to his podcast where he discusses the […]

  3. Preparing For Pregnancy With MTHFR Mutations • MTHFR Living - November 13, 2013

    […] The good news is that there is a lot that you can do to ensure healthy outcomes for you and your family when trying to become pregnant. The first thing will be to ensure that you and your partner are methylating properly and receiving the correct nutritional support. […]

  4. Older Mothers Put a Strain on Midwives (Commentary on the Guardian-UK Article) | Mothering in the Middle - January 9, 2014

    […] gives a pretty good list of the pathology associated with folic acid use. And the nutrition that optimized well-being: […]

  5. MTHFR C677T変異に対する基本プロトコル | - August 30, 2014

    […] 妊婦向けサプリに関する詳しい情報はこちら […]

  6. MTHFR and me. | createdfamily - January 4, 2015

    […] making some changes, particularly in what supplements I’m taking. This is a slightly overwhelming list of recommendations for preconception and pregnancy for folks with MTHFR. I’m starting with […]

Leave a Reply

Read previous post:
“MTHFRade” is the MTHFR Drink Formula. Have yours yet?

Having done 1000's of consults for MTHFR and working with nearly triple that through email correspondence, I have seen a trend...