Comparison of Homocysteine Support Products

MTHFR Product Comparison

MTHFR Product Comparison

Many are asking me, “Dr Ben, I am taking this ________. Is that any good for C677T or A1298C or…?”

I am finding that I am answering, “No” too often.

I have here all the top homocysteine-lowering medications which are prescribed commonly by doctors. Keep in mind that many doctors do not understand nutritional biochemistry. Nutritional biochemistry is extremely important to know especially when people are dealing with MTHFR mutations.

I’ll tell you right now: I am NOT impressed by 99% of the prescription drugs used currently for those with MTHFR mutations.


Let me show you the top drugs prescribed by doctors for MTHFR mutations first. Then, I’ll explain why I am not pleased with the formulations. You’ll totally understand by the end of this rant – and if you have any questions – please do comment below.

Comparison of Homocysteine Support Products
Drug or Product Folic Acid & Amount B12 & Amount B6 & Amount Add’l Ingredients Inactive Ingredients Rx Only Cost per Serving*
Folbee Folic Acid 2.5 mg Cyanocobalamin 1 mg Pyridoxine HCL 25 mg none For Folbee Plus: Croscarmellose Sodium, Dicalcium Phosphate, Hypromellose, Magnesium Silicate, Magnesium Stearate, Microcrystalline Cellulose, Mineral Oil, Sodium Lauryl Sulfate, Stearic Acid, Titanium Dioxide and Triacetin Yes $0.93
Folplex Folic acid 2.2 mg Cyanocobalamin 1 mg Pyridoxine HCL 25 mg none Dibasic Calcium Phosphate, Microcrystalline Cellulose, Modified Cellulose Gum, Crospovidone, Magnesium Stearate, Hypromellose, Titanium Dioxide, Polydextrose, Triacetin, Polyethylene Glycol, Iron Oxide Red, Iron Oxide Yellow Yes not found
CerefolinNAC L-Methylfolate Calcium (as Metafolin) 6 mg Methylcobalamin 2 mg N-Acetylcysteine 600 mg none Microcrystalline Cellulose, Opadry II Blue 07F90856 (Hypromellose, Talc, Titanium Dioxide, Polyethylene Glycol, FD&C Blue #2-Aluminum Lake, Saccharin Sodium), and Magnesium Stearate (Vegetable Source) Yes not found
Deplin 7.5 mg L-methylfolate Calcium (as Metafolin) 7.5 mg none none none Dibasic Calcium Phosphate Dihydrate, Silicified Microcrystalline Cellulose 90, Silicified Microcrystalline Cellulose HD 90, Opadry II Blue 85F90748 (Polyvinyl Alcohol, Titanium Dioxide [color], PEG 3350, Talc and FD&C Blue #2[color]),L-methylfolate Calcium, Magnesium Stearate (Vegetable Source), and Carnauba Wax Yes $3.19
Deplin 15 mg L-methylfolate Calcium (as Metafolin) 15 mg none none none Dibasic Calcium Phosphate Dihydrate, Silicified Microcrystalline Cellulose 90, Opadry II Orange 85F43102, (Polyvinyl Alcohol, Titanium Dioxide [color], PEG 3350, Talc, FD&C Yellow #6[color], FD&C Yellow #5[color], FD&C Red #40[color] and FD&C Blue #2[color]), L-methylfolate Calcium, Magnesium Stearate (Vegetable Source), and Carnauba Wax. Yes $3.22
Folgard RX (Foltx, Homocysteine Formula (not sure which form) 2.2 mg 25 mg (not sure which form) 1 mg (not sure which form) none Carnuba Wax, citric acid, corn starch, dicalcium phosphate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, riboflavin, silicone dioxide, sodium benzoate, sodium starch glycolate, sorbic acid, stearic acid and titanium oxide Yes $0.83
Folgard Folic acid 800 mcg Cyanocobalamin 115 mcg Pyridoxine HCL 10 mg none Dicalcium Phosphate; Microcrystalline Cellulose; Starch; Sodium Starch Glycolate; Hydroxypropyl Methylcellulose; Stearic Acid; Titanium Dioxide; Magnesium Stearate; Polyethylene Glycol; Sodium Citrate; Citric Acid; Riboflavin; Blue 1 Lake; Polysorbate 80; Sodium Benzoate; Sorbic Acid; Silicon Dioxide; Carnauba Wax. No $0.28
Metanx Metafolin which is L-methylfolate 3 mg Methylcobalamin 2 mg Pyridoxal-5-phosphate 35 mg none Dibasic Calcium  Phosphate Dihydrate, Microcrystalline Cellulose 90, Microcrystalline Cellulose HD 90,  Pyridoxal-5´-Phosphate, Opadry II Purple 40L10045 (Polydextrose, Titanium Dioxide, Hypromellose 3cP, Hypromellose 6cP, Glycerol Triacetate, Hypromellose 50cP, FD&C Blue #2, FD&C Red #40, Polyglycol 800), Microcrystalline Cellulose 50, Opadry II Clear Y-19-7483 (Hypromellose 6cP, Maltodextrin, Hypromellose 3cP, Polyglycol 400, Hypromellose 50cP), Lmethylfolate Calcium, Magnesium Stearate, Methylcobalamin, and Carnauba Wax. Yes $1.48
FABB (brand name: Folgard RX) Folic acid 2.2 mg Cyanocobalamin 1 mg Pyridoxine 25 mg none Dicalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Silica, Magnesium Stearate, Hydroxypropyl Methylcellulose, Polyethylene Glycol   Yes $0.73


Dr Ben’s Comments

All homocysteine support prescription drugs are loaded with artificial ingredients such as coloring, preservatives, flow agents, caking agents and others.

Costs vary tremendously between all of them.

The prescription drugs for homocysteine support which do not use the active form of folate (L-methylfolate which is Metafolin) or 5-MTHF, are vastly inferior and should not be used in my opinion. Most people with elevated homocysteine likely have the MTHFR mutation in some fashion. That said, it is imperative that these individuals only take active forms of folate (Metafolin form) otherwise the homocysteine levels will not drop effectively and the individual will have elevated levels of folic acid. Having elevated levels of folic acid is not good and obviously having elevated levels of homocysteine is not good at all.

Having elevated blood levels of folic acid, which are unable to be metabolized (processed by the body), increases the growth of existing neoplasms (cancers). So, in my mind, taking prescription drugs such as Folplex and Folbee and Folguard are not good ideas – especially those individuals with MTHFR C677T mutations are they are unable to process folic acid properly causing folic acid to buildup.

I also do not like prescription drugs utilizing only active folate even if it is the Metafolin form of L-methylfolate. Typically, when one takes only folic acid, the danger of creating a vitamin B12 deficiency is significant and even more serious is the potential to not only create a vitamin B12 deficiency, but not be able to see it! Thus, one may have a vitamin B12 deficiency while taking only folic acid but the doctor will not be able to tell if they order standard labs – and most doctors do only standard labs.

Research is suggesting that L-methylfolate ‘may be less likely than folic acid to mask vitamin B12 deficiency. Folate therapy alone is inadequate for the treatment of a vitamin B12 deficiency.’ This is taken right from the precautionary section from the package insert of Deplin, a well-known high-dose L-methylfolate prescription only product. The package insert is citing five research articles so their information is accurate.

Research is constantly evolving and finding new things out on a daily basis. If current research states that L-methylfolate ‘may be less likely than folic acid to encourage the rate of growth of existing neoplasms,’ that is great. But what is the true definition of ‘may be less likely?’

If the whole point of adding L-methylfolate, vitamin B12 and vitamin B6 is to reduce homocysteine levels in the individual, then I believe finding the lowest optimum amount of each ingredient is a necessity.

Homocysteine is also lowered by more than just L-methylfolate, methylcobalamin and pyridoxal-5-phosphate. Homocysteine is directly lowered by trimethylglycine known as betaine or TMG. Why don’t these prescription medications use TMG? I don’t know.

It is also known that riboflavin, vitamin B2, is required to help reduce elevated homocysteine levels in those with homozygous C677T MTHFR mutations. One may say that adding riboflavin is not needed because the homozygous C677T mutation is not significant in the population. I absolutely disagree.

Riboflavin is inexpensive and if one is going to such an expense to help lower their homocysteine levels, then why not add the most active form of riboflavin possible?

My key point is this:
The main goal here is to lower homocysteine levels safely and effectively with the lowest cost to the individually financially and physically.

That said, if a homocysteine formula contains nutrients which enhance the breakdown of homocysteine from all possible angles, wouldn’t that be the safest option?


Why take more of L-methylfolate if it is not needed? L-methylfolate can only process so much homocysteine as it approaches homocysteine metabolism from one angle.

Adding TMG is a great idea as TMG completely reduces the need for high dose L-methylfolate as TMG bypasses the genetic mutation in MTHFR and is able to lower homocysteine directly. This means, that if a formula has added TMG, then the ability to lower the amounts of L-methylfolate and active B6 is possible to do.

Not only is the potential risk lessened, but the out of pocket expense is lessened as well. L-methylfolate is very expensive. TMG is not very expensive.

An often overlooked issue with prescription drugs for lowering homocysteine is they contain a ton of ‘garbage’ ingredients. These ‘inactive ingredients’ do not benefit the body at all and, in fact, may do harm especially for individuals who have problems in their methylation pathway. I know that MTHFR mutations cause defects in methylation pathways. If there is a defect in methylation, then toxins do not get metabolized well and they end up accumulating in the cells, nerves, fat and bones of the individual. The last thing a person suffering with MTHFR is more chemical burden.

Let’s summarize what we know about standard folic acid:

  • taking only high levels of folic acid now is dangerous as it may speed the rate of growth in existing cancer cells.
  • taking folic acid in the inferior forms is not smart as all who have the C677T MTHFR mutation cannot do anything, or if they can, very little gets processed.
  • a vitamin B12 deficiency may be hidden by taking high levels of folic acid tops it off as a no-no to take alone.
  • Keep in mind how many foods are fortified with standard folic acid. A ton. Breads, cereals, drinks, formulas and more.

Let’s summarize what we know about L-methylfolate:

  • taking high levels of L-methylfolate is safer than standard folic acid or folinic acid in terms of enhancing the growth of neoplasms.
  • L-methylfolate is rapidly utilized by those with MTHFR mutations as this form of folic acid readily bypasses the genetic mutation thereby lowering homocysteine levels. This is outstanding.
  • is less likely to mask a vitamin B12 deficiency when compared to standard folic acid

Let’s summarize what we know about lowering homocysteine:

  • inactive standard form of folic acid doesn’t work well at all for those with MTHFR mutations – especially the C677T mutation
  • active L-methylfolate works very well in lowering homocysteine as it bypasses the genetic defect of the MTHFR C677T mutation
  • TMG, also known as Betaine or Trimethylglycine, works well in lowering homocysteine safely and effectively
  • Vitamin B2, known as riboflavin, is needed by homozygous C677T MTHFR mutations in order to lower homocysteine effectively.
  • Vitamin B12 is needed in order to prevent a vitamin B12 deficiency and to also help lower homocysteine by donating a methyl group. This is why methylcobalamin is the preferred form of vitamin B12. If the individual takes an already methylated form of vitamin B12, the ability for it to help donate a methyl group in the reaction to lower homocysteine is immediate. Basically, methylcobalamin helps transform homocysteine to methionine. There is a less commonly known MTHRR mutation (MTRR A266G) which requires methylcobalmin in order to get homocysteine levels dropped.
  • Vitamin B6, the active form, is the backbone to get L-methylfolate and vitamin B12 to actively lower homocysteine. Without vitamin B6, this reaction does not take place. That said, vitamin B6 helps lower homocysteine.

If I had to choose one prescription drug to help lower homocysteine: Metanx.

However, I prefer getting the job done of lowering homocysteine with the least force possible and covering all angles in as pure and inexpensively as possible.

Optimizing homocysteine levels may be obtained with the above nutrients. HomocysteX Plus provides all the above supportive nutrients in one – and it is completely without synthetic folic acid.

Please do share which prescription drugs you are taking to lower homocysteine and to reduce your MTHFR symptoms. I will add them to the comparison form above.


Dr Lynch

Sources updated on 9/12/2011

  1. Folbee and Folbee Plus
  2. Deplin
  3. Folguard RX
  4. Folplex
  5. FABB
  6. Metanx
  7. CerefolinNAC

*Pricing sources found at and 

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55 Responses to “Comparison of Homocysteine Support Products”

  1. Dr Ben September 13, 2011 at 7:14 pm # Reply

    I received this email this morning:
    “Thanks Dr. Ben. Can you tell me what the Homocystex I am taking is currently doing for me? I know it is giving me B12. Is it also providing me the right levels of folic acid?”

    This individual was taking Metanx but did not want to continue due to all the ‘inactive ingredients’ found in it.

    My response:
    Each capsule of the current formulation of Homocystex provides you with:
    1 mg of B12 (active)
    800 mcg of 5-MTHF (active)
    25 mg of B6 (active)

    Metanx has:
    3 mg of L-methylfolate
    2 mg B12 (active)
    35 mg of B6 (active)

    To get to the similar levels of 5-MTHF found in Metanx, you will need to take 2 capsules of Homocystex twice a day.

    Two capsules twice a day of the current formula of Homocystex provides you with:
    3.2 mg of 5-MTHF
    4 mg of B12 (active)
    100 mg of B6 (active)

    According to the pricing and cost per serving, it is still less expensive to take Homocystex than it is Metanx even at 2 capsules twice a day.

    Spacing the dose out is safer and more effective than taking all at once.

    B vitamins are water soluble. So your body absorbs only what it needs and then you excrete the rest via your kidneys through urine.

    The problem is one does not want to have high amounts of excess folic acid or L-methylfolate in their blood as excess levels may cause promotion of existing cancer cells.

    This is why it is safer taking less of L-methylfolate or folic acid but more frequently.

    The only way to truly know if you are getting the ‘right’ levels of folic acid is to:
    – Monitor your homocysteine levels
    – Monitor your methylation pathway
    – Monitor your symptoms
    – Monitor your folic acid blood levels

    The new formulation of Homocystex is more effective at lowering homocysteine levels and bypassing the MTHFR mutation as it contains additional nutrients of active B2 and TMG.

    Again, the new formula of HomocysteX will be arriving September 23, 2011.

    Dr Ben

    • sue smith January 31, 2013 at 7:21 am # Reply

      I take 800 mg of l-5-methltetrahydrofolate for the mthfr c677t mutation and my folate has improved. I take it with b12 – 1000mg or more and 100 mg b-6. I see alot of different comments and side effects from drugs and this concerns me. Any comments out there???

    • MTHFRPatient June 20, 2013 at 10:12 pm # Reply

      Dr Ben,

      I’m a female who is diagnosed with MTHFR – Positive for two copies of A1298C mutation. I had 3 miscarriages in last 3 years :(. Did came across your website for MTHFR supplement which contains active form of Folic acid and Vitamin B12. I fetched an information that so “it is important to start low and work up’ Will it be oki to start with ‘Homocystex’ over ‘Metanx’ to start with for the reason that former is low dosage?

      Looking forward to your response on pins and needles

    • Dealsvirgo July 22, 2014 at 4:48 pm # Reply

      I’m diagnosed with MTHFR (MTHFR – Positive for two copies of A1298C mutation)

      I’m a vegetarian and usually try to eat well balanced diet. My homocysteine level came out to be normal when I was tested.

      I take one capsule of metanx daily. Would you still recommend me HomocysteX twice a day. I have heard that it contains with betaine (also known as trimethylglycine or TMG) which lowers homocysteine levels. I wondering that I could be in danger of lower homocysteine level by taking that ?

      your reply will be very highly appreciated.

  2. Dr Ben September 16, 2011 at 8:55 am # Reply

    Received this via email:
    ” Hi Dr Ben

    Thanks again for all the useful info you have posted on your various sites about mthfr…or as i call it the mother f…cker gene!

    I was wondering what treatment protocols you suggest for heterozygous changes on both 677 and 1298?

    I was diagnosed about a year ago and have been put on 6 x 800mcg of Solgars Metafolin, 1gm TMG and B12(the cyano version not the methyl version). It appears reading what you write and chatting on Facebook with Stirling that this may not be enough…to really manage it well, especially since I have a whole lot of attributable heath issues….not enough ink here to write the list but happy to furnish you with it if it helps…

    I was about to order from the states more of the above supplements but thought I might check in with you to hear your suggestions? Any advice or ideas would be really appreciated! Oh – and can your products be shipped to Australia?

    Many thanks

    will answer in a later post – lengthy answer.

    • Narelle September 18, 2011 at 7:51 am # Reply

      thank you! look forward to reading :)

  3. Dr Ben September 16, 2011 at 9:12 am # Reply

    Received via email:
    ” Dear Dr. B –

    Just read through your site and appreciate your understanding and explanation of working to help minimize the MTHFR complications. My 12 year old daughter was just diagnosed with MTHFR and I have been reading through your site as well as all other genetic sites I can find to best understand the mutation before working with her OBGYN practictioner to help with the mutation. The nurse prescribed a folic acid supplement over the phone, but from what I can gather, a folic acid supplement is only part of the solution and could actually cause more problems from elevated levels of homocysteine as well as possibly complications caused by B12 deficiency (hidden or otherwise). I wanted to confirm what I believe your thoughts are so I can explain my thoughts properly. From what I understand, L-Methylofolate is what is best needed, but can be very expensive and/or need medication in the form of (best alternative) metanx. It appears though that L-Methylofolate can be created by a combination of folic acid, riboflavin, B12 (perferably Methlcobalamin) to prevent any potential defficiencies, and B6 to act as the catalyst between these supplements. Do I have this correct?

    In addition, there is considerable mention of TMG/Betaine/Treimethlglycine, but I cannot understand the relationship, is this the same as L-Methylofolate (for all intents and purposes)….

    Also, I’ve read about two different prevelant forms of MTHFR, C677T and 1298C. Is there a good way to differentiate between the two and are the treatments for each the same. In addition, should there be more added precautions with, what appears to be the more serious of the two, C677T?

    I recognize that as my daughter gets older and nears the time in her life when she will want to have children, we will need to reinvestigate findings to insure the most up to date information is available for both her and her baby’s health, but my main interest now is insuring her and her body’s health through prevention of negative side effects.

    A couple final questions, she is very active in sports, is there anything we should know or be prepared for, especially during her menstrual cycle when bleeding and clotting is heavy?

    Also, we live in [deleted], are there any experts you would recommend in the area for ongoing practice?

    Thank you for your time, I truly appreciate your wealth of knowledge.

    [name deleted]

    —comprehensive answer needed – may need consult – but will respond as well later – need to sleep :)

    Had to answer it now…

    Hi [name deleted] –

    Thorough comment ;)

    Excellent questions.

    You have some things right, some wrong and need some information.

    First thing is you need to tell me what type of MTHFR mutation your daughter has.

    If she has it – you and/or your wife have something similar – if she is your biological daughter. Having said that, get tested yourselves if so.

    My information totally depends on what type of mutation she has – and then how to deal with it.

    I am working on developing a full MTHFR program for people – that is soup to nuts detailed.

    I put a shout out to all my colleagues who know about MTHFR or know a doc who does. Amazingly – no answer yet – or – perhaps not so amazing as no one seems to know about it.

    I’m trying to put a referral network together – but not easy.

    Metanx is very expensive – yes.

    I developed a product that is much less expensive and will be available next week. I will email you when it arrives. It is also better…as it contains TMG, B2 in addition to the active folate, b12 and b6.

    You cannot ‘create’ L-methylfolate through B12, B6, B2, etc – can’t happen.

    You have to buy it sadly.

    Cannot even get it from food.

    But you do need to have B12, B6, methylfolate, TMG and B2 to effectively reduce homocysteine and balance the deficiency caused by the MTHFR mutations.

    TMG is its own animal. The beauty of TMG is that it totally bypasses the genetic defect allowing TMG to breakdown homocysteine and help methylation processes. Very cool indeed. Amazing that the pharmaceutical geniuses didn’t see that. But I guess they don’t study biochem as much as I do – I’ve tons of years of it.

    C677T and A1298C mutations are totally different issues and when combined – even more fun and problematic as you get both their issues.

    They are both serious – but homozygous C677T is very serious – as is compound heterozygous.

    Right now – you need to find out which mutations she has and then go from there.

    If she is clotting heavily, she is low in EPA/DHA oils, magnesium and vitamin B6. Could also be the MTHFR gene defect causing clotting issues. Need to find out which one..

    For more information, you may schedule a consult. Don’t do that though until you find out which mutations she has.

    Best to you and your daughter. She’s lucky to have a dad like you watching her back.

    Dr Ben

  4. Wendy October 22, 2011 at 3:25 am # Reply

    Hi Dr. Ben,

    Long story, but my daughter’s ped nerologist tested her for three clotting factors. she came back homozygous for C677T. I then tested my whole family. I am compound heterozygous for C677T and A1289C. One of my sisters is homo C677T and my other sister and father are comppund hetero fof C677T and A1298C. I did a lot of research and had my md put me on Metanx even though my homocystine levels were normal (around 4). My daughter has also been supplemented with 1/2 Metanx (even though her homocystine levles were normal too). We avoid supplemented foods with folic acid,etc, but now I am wondering what I need to differently than my daughter because of our different mutations. Btw, my husband, son, and mother only have one C677T mutation. They are the lucky ones!!!

    • Dr Ben October 22, 2011 at 8:04 pm # Reply

      Wendy –

      I am glad you tested your whole family. That is excellent. Well done – seriously. Many just think of themselves meanwhile their entire family goes through life suffering from MTHFR and unable to do anything.

      You are right. Different mutations require different protocols and information.

      I am happy to help.

      You may schedule a consult here.

      In 30 minutes, we can accomplish a lot.

      One thing to note here is that homocysteine levels are not the only factor to look at with MTHFR – yet most doctors only look at that. It is not right for numerous reasons.

      I am glad you are taking MetanX – and your daughter.

      Your husband and son – and mother – also need to be on some sort of protocol – yet not as intensive as you, your sister, your daughter or father.

      In health,
      Dr Ben

      • Wendy October 23, 2011 at 3:46 pm # Reply

        Yes, I will schedule a consult. Just to give you a little more background info, I also had my B12 levels tested (as well as my daughter’s, dad’s, and sister’s) and they were all low. Since I have been on the methylcobalmin, my levels are up to 900 from 300. Good news. My daughter has had more extensive bloodwork. I think they tested everything that can be looked at. 13 vials worth of blood. I know that methaline (I think) was looked at, so I would like to go over those labs with you. Should I fax that information before our consult? Thanks, Wendy

        • Dr Ben October 24, 2011 at 6:03 am # Reply

          Wendy –

          Please fax the documents to 425-984-0816 (private dedicated fax line for my eyes only) if you’d like me to review them prior to the consult. It is a good idea if the records/labs provide useful information. If your labs are only a page or two, I’ll look at those at no additional cost with the consult.

          If extensive, please select 30 minutes of Records & Labs Review on the consult page when obtaining your block of desired time.

          I look forward to working with you and your family!

          Dr Ben

  5. Nancy LoPresto January 5, 2012 at 12:18 am # Reply

    My doctor just got the results of a methylene tetrahydrofolate test he ordered. The results showed that I am homozygous for the C677Tmutation and negative (normal)
    for the A1298C mutation in the MTHFR gene. He has prescribed a dietary supplement of Optimized Folate (L-Methylfolate) 1000 mcg. I am to take 1 tablet per day. Does this seem like the correct colution?

    • Dr Ben January 5, 2012 at 1:37 am # Reply

      Hi Nancy –

      I prefer to have people take methylcobalamin with their methylfolate in order to avoid methyl trapping.

      Also you may need to take more than 1 mg of methylfolate a day. Right now, no one really knows how much methylfolate one should take as there is no real standard ‘normal’ level of methylfolate yet.

      If you have some serious symptoms such as blood clotting, depression, or others relating to C677T, then you need further support to reduce these concerns and risks.

  6. Shari Miller June 2, 2012 at 1:51 am # Reply

    I had 3 miscarriages and tested positive for one copy of the C677T mutation and one copy of the A129C mutation. I am compound heterozygous. I was placed on 4mg folic acid, 200mg B6 and 500mcg B12 and a baby aspirin a day. I conceived a year later and carried him to term. He is now 2. I continued taking all of them after delivering but not the baby aspirin as I was nursing. After reading your information I am switching from folic acid to methylfolate. I am just not sure how much I should be taking of the methylfolate, B6 and B12. I would greatly appreciate this info. Thank you.

  7. Julia June 7, 2012 at 10:32 am # Reply

    Not sure whether it is just coincidence, but my Homocysteine levels have decreased with using “RediBeets” ‘red beet juice powder’ by AIM (The AIM Companies) in just a few months. And I only used half of a teaspoon once a day (directions are to use one full teaspoon twice a day). My levels were 9.5umol/L on Jan20th2012, 6umol/L on May8th2012 and 5.7umol/L on May23rd2012. Says on the product description: “RediBeets: A concentrated beetroot powder with only the fibre removed, contains essential enzymes along with the natural form of betaine, which aids in cleansing the liver and reducing homocysteine levels.”

  8. Paula Thomas March 5, 2013 at 3:53 am # Reply

    You mention there aren’t any products you are very happy with due to all the colorings and unnecessary ingredients. I met with my ND today to go over my methylation pathway results and she was suggesting a product made by Thorne who don’t use any of those nasty products that these other products use. Have you looked at Thorne’s Methylation product? They have two varieties, Methyl Guard and Methyl Guard Plus.

    Three capsules of Methyl Guard Plus contains the following ingredients:
    Riboflavin (as Riboflavin 5′-Phosphate Sodium) 90 mg
    Vitamin B6 (as Pyridoxal 5′-Phosphate) 45 mg
    Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 3 mg
    Vitamin B12 (as Methylcobalamin) 3 mg
    Betaine Anhydrous (Trimethylglycine) 1,800 mg
    Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.

    Does this sound like a good product to use?

    • Paula Thomas March 5, 2013 at 1:46 pm # Reply

      I know those amounts may be a little high for starting out but their non-plus version has lower amounts. For some reason they drop the riboflavin from the non-plus version.

      More info:

      3 capsules of this one contains:
      Vitamin B6 (as Pyridoxal 5′-Phosphate) 20.4 mg.
      Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1.2 mg.
      Vitamin B12 (as Methylcobalamin) 1.2 mg.
      Betaine Anhydrous (Trimethylglycine) 1.8 g.
      Other Ingredients: Hypromellose (derived from cellulose) capsule, MagnesiumCitrateLaurate, Silicon Dioxide.

      • Larry Alan September 19, 2013 at 2:19 pm # Reply

        Paula did you get a response re Methyl Guard? I’ve heard of it as well, have been taking Metanx, but wondering which is best etc. Any thoughts?

        • Paula Thomas December 27, 2013 at 6:32 pm # Reply

          Sorry just now seeing your question. I didn’t end up using Thorne’s product. I am taking Seeking Health’s B Complex and Yasko’s B12 and Folate drops.

    • Maureen March 29, 2014 at 5:10 am # Reply

      A response would be good regarding Methyl Guard Plus. I’ve just been newly diagnosed Hetero C667T. Dr told me to get Methyl Guard Plus. As I am in Australia I have ordered a number of bottles of this stuff from the US! Just starting on this journey, and not looking forward to the detox symptoms people speak off! Thanks.

  9. MTHFRgrl April 1, 2014 at 1:21 am # Reply

    Dr. Ben,

    I just found out last year, at 26 years old, that I had a Pulmonary Embolism (blood clot in my lung). Before I even knew it, was lying at home feeling i was having a panic attack and felt totally weird i.e.: out of body, everything was going in slow motion, and some chest pains.

    The next thing i know I wake up in an ambulance (I had a seizure) and i cannot even recall what season it was or when my birthday was, when they asked me these questions (normal after a seizure). I have never had a seizure in my life prior to this.

    I then was stabled in the hospital and my hematologist put me on Coumadin hoping it would dissolve the clot. She also checked my blood and told me I have MTHFR, but in a low case, whatever that means. I was also on birth control which apparently made the clot with MTHFR a lot worse.

    Now, i suffer from severe anxiety bc of all of the trauma I went through. I tried Lexapro which made me feel EXTREMELY weird and had an outer body experience, and the panic was worse. My doc concluded i was allergic to SSRI’s and i should never take them again.The only thing that helped me was Klonopin.

    Finally i researched that MTHFR can cause anxiety and depression…and that Deplin could be a good choice. I took one tonight, after consulting with my doctor, and haven’t felt anything yet. I know it takes time, but how much time before the Deplin will start doing its work?

    Please let me know! Thankyou!

  10. Heather S. June 25, 2014 at 3:56 pm # Reply

    Dr. Ben,

    I’m somewhat confused, can you please clarify…are you stating that a homozygous individual should take an RX of the L-methylfolate in addition to the supplements that you’ve listed because those persons need more folate than a heterozygous? I would greatly appreciate your insight.

    Best Regards,
    Heather S.

  11. Rebekah July 1, 2014 at 12:24 am # Reply

    Please adjust the ads on this page so the full table is visible.


  12. Michaela September 10, 2014 at 3:08 am # Reply


    I am new to this site, and only beginning to learn. From my lab report I gather that I have the double mutation of the C677T. It is listed in red as positive with the marker “T/T”. I have been prescribed Deplin, Armour thyroid, B12 SHOTS, and a host of other supplements. I have been feeling a lot better, but not 100%. At my last check a few weeks ago my homocystein levels were finally in the green.
    I have not yet had a chance to surf this site extensively, but from what I have read so far, I have not seen B12 shots listed as an alternative to oral B12. I cannot absorb oral B12, therefore the shots.
    Are you able to fill me in?
    I am also ready to stop taking the Deplin and try your alternative instead.
    I look forward to hearing from you.

    • Dr Lynch September 11, 2014 at 6:54 am # Reply

      Shots work for B12 for many people – I find them overkill for many people – not necessary. Why can’t you absorb B12? Studies show that even with pernicious anemia, high dose B12 lozenges elevate B12 levels. Yes, T/T = the risk alleles for the MTHFR 677 variant. The alternative I formulated is not nearly as potent as Deplin but I also dont believe Deplin is the right choice for many people. If you feel good on it, great – it may be for you; however, if you start getting side effects, then time to reconsider. Some people do well for a while with methylfolate at high dose and then need to drop down very low. HomocysteX Plus is the formula I’ve designed to support the methionine cycle.

  13. Melinda Roman September 13, 2014 at 2:37 pm # Reply

    Based on complete genetic profile it seems that some people tolerate hydroxyl b12 better than methyl b12. Is there a product, multivitamin that contains hydroxyl instead of mehyl b12?

  14. Paula October 29, 2014 at 6:48 am # Reply

    Hello, Dr Ben,

    I recently had extensive lab tests done that revealed info under the “Coagulation Genetics” category regarding 2 subgroups:
    1. Subgroup: MTHFR (A1298C) rs 1801131, revealed “Intermediate risk,” @ an estimated genotype frequency: A/C (~ 30%)

    2. Subgroup: MTHFR- C677T (rs1801133; Methylenetetrahydrofolate Reductase) revealed “Optimal,” @ an estimated genotype frequency: C/C (~ 49.3%).

    3. As a history, I am 65 years old, and about 25 years ago I started having some mild blood coagulation problems that manifested themselves when I was donating blood. It would come out slower and eventually stop, so I could not donate the full pint, and had to stop giving blood. I never checked into this, but it can still happen when a doctor draws blood for testing. If they need alot, it ends up slowing down considerably and they get the blood but it takes awhile. With these new lab test results for #2 subgroup above, the doctors office recommended l methylfolate to improve brain functioning and help prevent blood clots.

    Also, about 25 years ago I started having extensive digestive issues that manifested itself in diverticulitis, IBS, leaky gut, fibromyalgia, chronic fatiguea, thyroid issues / inflammation, autoimmune type things, and some brain fog and memory issues. Recently through all the research I have done, I put 2 + 2 together about the digestive/leaky gut problems, and how the thinning of the intestinal walls c created an environment were foods/bacteria could leak and cross the blood/brain barrier. Seven months ago I had a severe attack of IBS and small growth bacteria and this ended up resulting in healing with antibiotics/non gluten wheat diet and non processed foods (which I have been doing for 7 months). Whereas, 25 years ago I noticed brain fog and minor memory issues that have lingered, this eposode I noticed another level lower in my memory challenges, which greatly concerns me.That, combined with the above lab finding regarding subgroup 1, hence, I am writing you.

    My doctor just prescribed “podiapn, which is a medical food. She relayed that this was methyfolate, a less expensive one. Can you please provide your view on my lab numbers, and this prescription and what it is? There was no written documentation with it, maybe because it is described as a medical food? Thanks in advance for your help.

  15. Laura November 5, 2014 at 4:26 pm # Reply

    Hi Dr. Ben,

    I’m 7 weeks pregnant and seeing a Reproductive Immunologist who just prescribed me to take Metanx, once daily. I was dx with MTHFR 677T (heterozygous) mutation but also a PAI-1 heterozygous mutation (not sure if you’re familiar with this one). She has me on a prescription prenatal called vitaPearl, which has the activated folic acid (4mg?) and now wants me to take the Metanx. I’ve been trying to find research saying whether this is safe to take during pregnancy, but really there’s not much out there about it, and everything says it’s unknown whether it’s safe to take. What are your thoughts on taking Metanx if pregnant?

    Thank you,

  16. brother's keeper November 18, 2014 at 8:43 pm # Reply

    I read the following quote in one of you’re replies. Please help me understand. If I can buy a supplement, then I should be able to get its elements from what the supplement is made of. Some item in creation, or you couldn’t put it together to sell it. It doesn’t make sense that there it’s no food or substance somewhere I can take in some form of you can get it to make your formula.

    “You cannot ‘create’ L-methylfolate through B12, B6, B2, etc – can’t happen.

    You have to buy it sadly.

    Cannot even get it from food.

    But you do need to have B12, B6, methylfolate, TMG and B2 to effectively reduce homocysteine and balance the deficiency caused by the MTHFR mutations.

    • Dr Lynch November 19, 2014 at 12:06 am # Reply

      Hello –

      You CAN get methylfolate from food – leafy greens. That statement is old and incorrect. Love to know where that statement is so I can fix it.

      • Hanna November 19, 2014 at 9:10 am # Reply

        It’s higher up on this page, posted on Sept 16, 2011.

      • Elizabeth January 11, 2015 at 10:31 pm # Reply

        Dr. Lynch,
        I am compound heterozygous for MTHFR. Would your Optimal Prenatal contain all I need for pregnancy or should I also add something extra?? Please help. Thank you!

      • Kelly January 12, 2015 at 8:24 pm # Reply

        Just to let you know Dr. Lynch — it still says above that you can’t get methylfolate from food.

        My quick question: Can one take too much TMG? And if so, how would that affect methionine synthase and folate metabolism?

        Thank you for all your work!

  17. Christi January 15, 2015 at 12:39 am # Reply

    I had to ask my DR to test me after my brother tested positive. I have the 677 and the 1298. I’ve had cancer 3 times, been diagnosed with CFS and fibromyalgia among other things. I’ve always taken b12 injections since I was 18 but not the methyl b12. I’ve ordered a couple things from Thorne but I really dont know what I should be doing. I would love to feel better! My doctor said ‘yes, you have it but theres really nothing you can do about it’. Where do I start??

  18. Heather January 15, 2015 at 6:45 pm # Reply

    Hi Dr. Ben,

    I just found your website. I am specifically interested in what to do for my 11-year-old daughter who was diagnosed as homozygous for the A1298C mutation when she was 6-years-old. I have been giving her 400mcg of 5-mthf since then, but wonder what else I should do. Her pediatrician tested her for the gene defect because she has severe anxiety, proprioceptive sensory dysfunction, dyslexia, and visual sensory integration.

    I just wonder if there’s anything else I should be doing to increase her ability to function normally. It’s such a difficult thing to measure without a baseline. Most of the info I’ve found on your site addresses the other (677) mutation.

    Is there a typical supplement recommendation for the homozygous 1298?

    Thanks so much,

    • Dr Lynch January 15, 2015 at 9:39 pm # Reply

      Heather –

      Use the same info which discusses 677 – it’s basically the same thing – in fact it is. Just lower amounts of methylfolate are needed – but not always – some people need more or less methylfolate regardless of their MTHFR status – for various reasons.

      • Elizabeth January 15, 2015 at 10:16 pm # Reply

        Hello Dr. Ben,

        I saw a great doctor about my compound heterozygous MTHFR. He suggested I take 1000 mcg of methylfolate a day and 500 mcg of methylcobalmin twice a week to start out, and work up to 500 mcg three times a week if tolerated. I have experienced anxiety issues in the past, but since eliminating gluten and dairy I have felt great. I am really trying to avoid getting overmethylation symptoms b/c I don’t want to feel anxious. My questions are-

        Will 500 mcg of methylcobalmin twice a week along with 1000 mcg of methylfolate a day prevent the methy blocking I read about that can occur if you don’t have enough B12?

        Since we are getting ready to start trying to have another baby (after 4 losses), I would like to start taking your prenatal multivitamin. I think the doses of folate and B12 in it are pretty close to what my doctor told me. The methylfolate is 200 mcg less per day, but that wouldn’t matter much right??

        Thank you!

  19. Amy February 2, 2015 at 3:04 pm # Reply

    Hello, I am homozygous C677T, with depression since childhood plus other symptoms, my doctor gave me samples of EnLyte, which has 8 mg or so of folic acid in various forms, and 25 mcg of other b vitamins. I started taking the pills, but then was warned by others that it may be too much folic acid. So I stopped. Now I want to get my homocysteine tested but don’t know how long to wait after stopping the EnLyte to get a good baseline reading. Your thoughts?

    • Dr Lynch February 4, 2015 at 5:02 am # Reply

      I’d consider testing in one month. Folic acid has a long 1/2 life.

      • Amy February 4, 2015 at 7:31 pm # Reply

        Thanks, Dr. Lynch!

  20. Bob February 8, 2015 at 5:23 am # Reply

    Hi Ben, hear about you through Sean Croxton. I tested positive for the MTHFR A1298C G/G homozygous and my wife tested positive for MTHFR C677T A/A homozygous.

    1) I am trying to understand what these letters G/G & A/A mean then I see CC, AC etc. I have been searching for days for an answer, what is G/G for me, then A/A for my wife? have a link that explains this in layman terms?

    2) Can we both take the same supplementation? not clear on that. Then do you have a product/supplement for this? What would you suggest we take?

    3) We had two children, It sound like that they could be Compound Heterozygous or Compound Homozygous. They are 25 & 30 yrs old now and one is Type 1 diabetic and the other has been diagnosed with Celiac. I suppose they should get tested or since we both have the mutations it is pretty much guaranteed they have it right? its just a matter of Homo or Heter & I suspect being compound, right?

    Thanks for your help in clarification on this.

  21. Ashley March 5, 2015 at 4:43 pm # Reply

    Hi Dr. Ben,

    I have heterogenous mutations. Is the Homocystex Plus supplement safe to take while breastfeeding? I took Folgard RX throughout the pregnancy and for the first 5 months of breastfeeding per my RE. Or should I stop supplementation and resume when I stop breastfeeding? Thank you!

    • Dr Lynch March 7, 2015 at 12:39 am # Reply

      Hi Ashley – I would read this and consider these suggestions:

      • Elizabeth March 7, 2015 at 1:20 am # Reply

        Dr. Lynch,
        I am compound heter for MTHFR. My homocysteine level was 7.2. What all do you recommend I do to stay healthy now that I know I have MTHFR?? I already avoid gluten, most dairy, and eat organic. I of course now avoid folic acid too.

        Also since I am compound heterozygous and my husband is negative for any MTHFR…..what likely combinations would our kids have??

        Thank you so much for your help.


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