Dr Lynch Family: Myriad of MTHFR Mutations


[Press the ” > ” button above and turn up your volume.]

Listen to Dr Lynch discuss his recent findings of how his entire family has MTHFR mutations – and some severe forms.

How is that the path we take in life is somehow absolutely appropriate and fitting for us?

Becoming a naturopathic physician with a specialty in environmental medicine and nutrigenomics, I am stunned at how critical this path was for me – and for my family.
If I had not chosen this path, two of my boys would most likely be quite autistic, my wife would be suffering from rheumatoid arthritis and my health would have been severely compromised.

As one who has spent a lot of time with MTHFR research and working with countless clients with MTHFR, I can safely say I am quite well-versed in MTHFR mutations.

I was waiting until my new comprehensive genetic test was nearly completed before I tested myself and my family for MTHFR.

As I nervously opened the PDF documents for each member of my family, I was blown away. (I am glad I was on vacation when I opened these documents.)

  • Theodor Lynch, Male, Age 3: Homozygous A1298C + Heterozygous C677T
  • Mathew Lynch, Male, Age 6: Heterozygous A1298C + Heterozygous C677T
  • Tasman Lynch, Male, Age 9, Heterozygous C677T
  • Nadia Lynch, Female, Age 35, Heterozygous A1298C
  • Benjamin Lynch, Male, Age 38, Heterozygous A1298C + Heterozygous C677T

My mindset totally shifted from simply being a father to suddenly being my childrens’ guide and physician. Without my assistance, their future is grim.

“Oh, shit.”

Yes. Those were the exact words when I saw Theodor’s and Mathew’s test results.

A million concerns ran through my head wondering what I should do.

Then, I realized something.

“I’m already doing something for them – many ‘somethings’.”

  1. Gluten Free Diet
  2. Dairy Free Diet
  3. Probiotics
  4. Sauna for whole family at least 20 times a year
  5. Filtered water
  6. No carpets in the house
  7. Air purification
  8. Organic food
  9. Very limited processed foods
  10. No artificial soaps, odors, perfumes
  11. No cleaning solutions – just natural soaps, vinegar
  12. Limited pressboard in our home
  13. Organic bedding and mattresses
  14. Multivitamin with methylfolate, pure fish oil, CoQ10, Cal/Mag, vitamin D3
  15. Limited sugar intake
  16. No soda
  17. Highly active in sports and outdoors for all of us
  18. Studying piano
  19. Speaking and learning Russian

All of these are critical to treating MTHFR mutations.

Many doctors typically tell their patients with newly diagnosed MTHFR mutations:

  • “Take 5 mg of folic acid a day and you’ll be fine.”
  • “MTHFR is nothing to worry about.”
  • “Take 1 x 15 mg Deplin daily and you’ll be great.”
  • “Take NeevoDHA while pregnant along with Lovenox and all will be great.”

All of these recommendations are wrong – in my opinion.

If you are not doing 1 through 16 above, then you are not fully addressing your MTHFR mutation.

Let me give you some more background: 

Both Mathew and Theo were slow to speak yet are quite healthy overall.

Mathew’s speech is now fantastic yet he has an accent – I believe this comes from his mother’s thick Russian accent. She was his one and only person to interact with – well – besides his older brother.  I was not around in his younger years (medical school is extremely demanding for 5 years). Then add on the fact that Mathew was not in an English speaking daycare/preschool until later.

Slow speech can be attributed to a few things in Mathew’s and Theo’s life:

  1. We’re a bilingual family: Russian and English
  2. Summers spent in Russia during critical language development (no English spoken).
  3. MTHFR mutations
  4. Me having been in medical school and not around much to interact with my children.
  5. Not starting an English preschool or interaction with many other English speaking children until later – age 5 for Mathew. Theodor is in Russian preschool now.

I smiled when I saw my wife’s MTHFR results.

I test her for everything and she nearly always comes back squeaky clean yet she suffered terribly with Rheumatoid Arthritis from the young age of 17 until 31.

She now is literally ‘normal’ and living life without rheumatoid arthritis.

How?

Lifestyle, diet and supplements.

Medications? NONE.

“Is that right?”

These were the words I internally said to myself as I stared at the lab report for Benjamin Lynch.

1 copy of A1298C and 1 copy of C677T

I was amazingly calm but confused.

How come I am not showing more symptoms?

I used to.

I now follow points 1 to 17 on the above list and have been for years. This is why I show no symptoms.

In a nutshell:

MTHFR mutations do not control you. You control them.

I, and my family, are living proof that you can beat MTHFR mutations through proper lifestyle, diet and supplementation – and mindset.

How much methylfolate are we all taking?

None of us are taking more than 400 mcg a day currently.

MTHFR is not about methylfolate.

MTHFR mutations demand a healthy lifestyle and some methylfolate.

I’m sorry.

There is no pill for MTHFR.

There is no surgery for MTHFR.

What there is for MTHFR is work and awareness.

If you respect what you put into your body and what is around it, you’ll lead a healthy life.

Now – it is not always this easy.

Why not?

Because there are other potential mutations which increase the severity of the MTHFR mutation.

COMT, VDR, CBS, MTR/MTRR, BHMT, MAO A, DHPR, SUOX, SOD, GST, NOS – to name a few.

Main point I want to leave you with though is you control your genetics.

They do not control you.

 

 

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20 Responses to “Dr Lynch Family: Myriad of MTHFR Mutations”

  1. Thomas' mom February 7, 2012 at 7:22 pm # Reply

    Wow! So you are living out the saying “physician, heal thyself (and family)”. I hope it continues to go well for you. As my son spent the 1st year of his life in a Russian DyedestkI Dom, I enjoy reading about your Russian connection.
    I find the frequency of positive test results for MTHFR very interesting. I wonder what percentage of those tested actually have negative results for all forms?

  2. Lisa February 12, 2012 at 8:01 pm # Reply

    Dr. Lynch, thank you for all this information.

    I’ve recently learned of my MTHFR status; 1 copy of each, C677 and 1298. I have yet to test my kids. I’ve also done the Genovations test and found I have COMT which I realize compounds the issues.

    In reading your website this all explains SO much of my health history. I agree with your statement regarding our life path being so perfect for what we need. I’ve been in the health and fitness industry for many years and very passionate about food and alternative health. My kids were born at home, not vaccinated, neither has ever had antibiotics, eat organic, grass fed, gluten free, experiment with raw dairy, etc. etc. We have been eating only GAPS legal foods for over a year, more recently adding in sweet potatoes.

    My kids are healthy but with multiple food intolerances. I’ve learned so much about this over the years I feel like I’ve become an expert in the area……which really means I’m so totally confused because there are so many options for ‘healing’…….leaky gut, etc.

    I’ve done Organix Acids thru metametrix on myself and my 6 year old, a few times over the years and always saw issues in the metylation pathways, specifically with the b vitamins. I always wondered how this could be because I was taking B’s! Well, now I know!

    My 6 year old was just diagnosed with a mild tongue tie, which my younger broth and nephew both have.

    I could go on and on with my health history and how this makes it all make sense now.

    SO, I want to help my kids. Thankfully I’m already doing so many of the things you have listed above. I would like to eventually do a consultation for myself and children but want to have all the best information before we do. Should we do more Organic Acid testing or the ION panel, or just your new genetic test when it comes out? Would would help the best?

    I also have a question. I believe I read on Amy Yaskos site that just because you have a gene defect, does not mean the gene is down regulated. It could be up regulated or just mal functioning? Or maybe I understood that wrong?

    I haven’t dove into supplements to much yet because I think I need to get more answers. My kids do cod liver oil and I’ve recently started P5P and methyl folate, but no b12, with my 6 year old and I. I don’t have any testing or knowledge on my 2 1/2 year old.

    Anyway, thank you for this work. Let me know what you think would be the best way to proceed for getting info and then consultation. And could I do a consult for my family all at once?

    Lisa

  3. jada February 18, 2012 at 3:54 am # Reply

    Great article! YOur children are lucky to have you.

    Can you recommend and post what air purification you use?
    Do you use an infared sauna?

    thanks!
    Jada

    • Dr Ben February 20, 2012 at 3:20 am # Reply

      Hi Jada –

      Lucky to have a father who is compound heterozygous MTHFR?! :)

      I use the Alen Air Purifiers.

      I have 4 different Air Purifiers – depending on location, purpose and square footage.
      - Alen A375UV: Living Room – on all the time
      - Alen A375UV: Mathew’s Room – most sensitive to impure air – on randomly
      - Alen T300: my office – used to be on all the time – now at times – I leave the windows open typically as I have pure air outside here.
      - Alen A350: our bedroom

      If you are looking for large square foot coverage, elimination of odors and chemicals, then I recommend the Alen A375UV purifier.

      I recommend these over the IQAir purifiers due to huge cost savings for basically no loss in performance.

      Filter replacement and maintenance is also very easy.

      Water Purifiers:
      - I use two:
      1) Premium 10 Stage Countertop Water Filter:
      - excellent to take with us on road trips or overseas trips. Just take a wrench with you along with some other adapters and you all get clean water for pennies per gallon compared to dirty bottled water at dollars per liter.
      - also can use at home – great water filter

      2) Akai Ionizer Plus.
      - this is a higher-end water purifier that also lowers the pH of the water and reduces the water clusters into smaller ones making the water penetrate membranes better (so they say).
      - I cannot vouch for that scientifically but I can say when I first started using it, I drank water non-stop. I couldn’t stop drinking it and neither could my wife. We did this for the first month of having it.
      - I’ve used this one in our home for 12 years now.
      - If you say you were referred by Dr Ben Lynch, you save $300 off the price. I don’t know what it is listed at anymore – been too long. (Disclosure: I do receive a small kick-back for recommending it; however, I would not recommend anything if I didn’t trust it and/or use it personally)

      For the sauna, I use an infrared sauna also from High Tech Health.
      They have a new one out but I don’t recommend it over the original Thermal Life saunas.

      I use, and my neighbors also enjoy it ;), the 3 person Thermal Life Far Infrared Sauna by High Tech Health.
      I use this one as it is pure and doesn’t use any bad materials.
      - If you mention you were referred by Dr Ben Lynch, you will save $500 off any sauna (same disclosure).

      I am glad you are looking to reduce exposures.

      This is much more effective than detoxing. Preventing the toxin exposure in the first place is an absolute must.

      I want to share with you two other things:
      1) Shower Chlorine Filter: install this and have another one to take with you on trips to hotels (wrench applies also :) )

      2) Get some basic vitamin C powder and add about 1 tablespoon to a bath. This removes the chlorine. Add more if needed!

  4. Kim March 9, 2012 at 2:04 pm # Reply

    I enjoy a steam room much more than a sauna how do you feel that they differ and is a steam room ok instead of sauna?

    thank you

    Kim

    • Dr Ben March 9, 2012 at 6:44 pm # Reply

      Kim -

      A steam room does not heat deeply into the tissues so it is not nearly as good as a sauna between the temperatures of 120 degrees F and 130 degrees F. The goal is to allow your body to heat as deeply as possible which mobilizes toxins from the adipose tissue and into the blood stream where then your liver/kidney can process them.

      • Kim March 16, 2012 at 6:17 pm # Reply

        Dr. Ben,

        Thank you for your reply that helps me to understand the difference. I honestly could not find anything online for that questions.

        Thanks

  5. k.w. April 4, 2012 at 3:31 pm # Reply

    Great article! How do you test for COMT?

  6. Stephanie October 5, 2012 at 2:02 am # Reply

    Dr.Lynch, I have been ill on an off for many years…told I had Lupus, no, connective tissue disease, no fibromyalgia, chronic fatigue syndrome, now atypical migraines….the list just goes on and on. I recently discovered I tested positive heterozygous for c677t and a1298c. I was prescribed 325 mg per day and 1 mg Folic Acid…by the way I am a RN. I have been doing a lot of reading and I am no longer taking folic acid. I take, 7 mg methylfolate, B12 IM 1 cc weekly and some other supplements (pretty much everything Methyl Guard contains)…drinking filtered water, eating as clean as possible….very little processed food, etc but I have a couple of questions….

    1. I went to try out a infrared sauna this week…I didnt sweat a drop despite the fact it was 140 degrees….that seems very weird to me. How can I detox if I don’t sweat? do you know anything about the ionic foot detox system? I went to a spa and had this done. It looked legit but I wondering what you thought.

    2. Can you recommend a company that test for all known gene mutations that effect the body in similar ways as c677t and a1298c? I want to be sure to identify all the areas that may be affecting my health.

    • Ann Wadley November 30, 2013 at 2:33 pm # Reply

      I am curious to know the response to the questions from the woman above. I have a very similar history and I also cannot sweat. This is very new information to me and very interesting. AW

  7. Maria November 11, 2012 at 2:05 pm # Reply

    Hello Dr. Lynch,
    I have a 4 yo girl who is overloaded with heavy metals, yeast, dx of autism . She has double copy of the A1298C. She is on GFCF / gaps diet ( no grains, sugar, and everything she eats is organic), lots of probioitcs, we have a water filter that alkalines the water, she is currently on most of the supplements you mentioned ( calcium, magnessium citrate, vit. D3, fermented cod liver oil, grass fed butter oil, here are my questions:

    1- She is currently taking leucovorin calcium 5 mg 2x/day. Is this something you would recommend for a 4 yo ( with a 45 lb wt) Qand is it enough?

    2- the shower water filtration that you mentioned, is possible for you to share the brand that you use? There is so many brands on the market and need one that is reliable.

    3- which brand mvi would you consider excellent?
    Thank you so much for everything you have done,
    Maria

    • Dr Ben November 13, 2012 at 11:06 pm # Reply

      Maria –

      1) That seems like a lot but if her moods are stable and she appears alert, happy – that could be useful.

      2) I use New Wave Enviro Products Shower Purifier from Healthy Goods.

      3) I consider Seeking Health multivitamins to be excellent :) but I am a bit biased as that is my own line of supplements. I use them on my kids (when they’re misbehaving – jk) ;)

      We have adult multivitamins, children’s multivitamins and a chewable multivitamin which can be used by both kids and adults. I am working on a prenatal but have yet had sufficient time to finish the formula.

      I also find multivitamins by Pure Encapsulations, Xymogen and Designs for Health to be pretty good. Your support of Seeking Health is appreciated should you choose it!

  8. Katie March 8, 2013 at 5:10 pm # Reply

    Just recently stumbled upon this website, but have not gotten to go through much of it yet.

    I am homozygous a1298c, and learning a lot from this site.

    I just wanted to say what a great website you got going on here, the podcasts are great as well! Thank you!

  9. Jennifer Thomas January 10, 2014 at 9:30 pm # Reply

    Dear Dr. Lynch,
    Thank you so much for this article, it brings peace to see a plan that is not so overwhelming!! My 19 year old daughter’s health problems led us to test for Mthfr, and it turns out that she, her twin, and her 3 year old sister are Homozygous 677t, and me and her 5 year old sister are Heterozygous 1298c-Heterzygous 677t. My daughter who has been having the health problems has been doing the gaps diet, and we have been learning a lot and plan to implement 1-16 on your list, my question is..would the multivitamins you recommended be a good place to start as far as a supplement for the mthfr for the little girls (5, and 3)? I plan on a slow plan of action, getting their gut health in order, and cleaning up their environment and diet, when should I start them on the vitamins you recommend? Their father has recently been tested for mthfr by the VA, and I am very curious to see his results, desert storm veteran, 100 percent disabled, migraines, nerve damage, narcolepsy, psoriasis etc…Thank you so much for your time, and your research! Our family will never be the same!! and that’s a good thing!!
    Sincerely,
    Jennifer Thomas

  10. judith fenton January 13, 2014 at 9:45 pm # Reply

    I am 74 years old and just on a lark I had some genetic testing done only because it was part of a comprehensive assay my doctor had me do. He rarely tests for too much, but once in awhile he finds a “new Toy” , I got back the results of the MTHFR c677t and found I had T/T high risk.=, but the A1298C was normal. I never had a mis-carriage and seem to be in excellent health except for worrying about my health. So I got into the internet and went nuts. I found I could get every malady known to man. I really had to get a grip because I have tinnitus that gets worse when I get stressed. I started getting so upset as I spent hours reading scientific data I couldn’t understand except that this snp makes one susceptible to blood cancers, cardio vascular disease, psychiatric disorders and on and on. One genetic test for alzheimers came back that I had inherited a gene from each parent protects me from that disease. I do take care of myself and do a lot of what you recommend anyway as it makes sense. I am neurotic so maybe that is caused by the snp. I come from a long line of women who live well into their 90′s. My mother included who was never sick a day and always felt good. So where does all this come from? Once I read that you don’t have to be ruled by your genes I felt better. I now am trying to keep calm and live another 20 years ingood health!! JUDY

  11. Naomi January 30, 2014 at 7:14 pm # Reply

    Hi Dr. Lynch –
    I am currently awaiting the results of a 23andMe test on myself, but due to my medical history and that of my family, I strongly believe that not only do I have an active mutation, but that my 3 year old son does too. I would like to begin supplementing immediately and really like your children’s chewable multivitamin formulation (on the Seeking Health site), but am concerned as it is only recommended for 4 years and older. I’ve checked the RDAs for toddlers his age, but there aren’t a lot of resources out there and there doesn’t seem to be consensus amongst them. My little man is barely in the 5th percentile for his age in terms of weight and is closer to 3 than 4, so I’m wondering if it would be safe to give him a half dose of the Seeking Health children’s multivitamin?

  12. Dr Serene Lim March 6, 2014 at 8:40 am # Reply

    Thanks so much for your research Ben. This is so exciting. Explaining to my patients was so time consuming and their eyes would glaze over when I mentioned biochemistry or genes that I did a simplified youtube. http://m.youtube.com/watch?v=kop2c_89mc0

    The second video ( released soon) mentions your great conferences.

    • Dr Lynch March 6, 2014 at 9:13 pm # Reply

      Serene – well done ;)

      Awesome that you made it simple. That’s key.

      And thank you much for mentioning my conferences – much appreciated.

  13. Laura May 21, 2014 at 11:58 pm # Reply

    Dr Ben,

    I’ve been on your site constantly for several weeks since doing the 23andme test. I have noticed in several places you mention that other mutations can make things more difficult. I have the COMT, CBS, BHMT, NOS, and several others in heterozygous form, as well as heterozygous A1298. Do you have recommendations for people like myself? I’d like to follow your general protocol but a few comments you have made make me think maybe it won’t go as well for me since I have other mutations. Thanks for any advice.

  14. Michelle August 12, 2014 at 9:22 am # Reply

    It is interesting your son, Tasman, does not have the A1298C mutation. So it is possible to “escape” mutation? Perhaps my son is not mutated when my husband and I are?

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